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Journal of the International Association of Providers of AIDS Care

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https://www.readbyqxmd.com/read/28198210/a-minority-of-patients-newly-diagnosed-with-aids-are-started-on-antiretroviral-therapy-at-the-time-of-diagnosis-in-a-large-public-hospital-in-the-southeastern-united-states
#1
Neela D Goswami, Jonathan Colasanti, Jonathan J Khoubian, Yijian Huang, Wendy S Armstrong, Carlos Del Rio
Prompt antiretroviral therapy (ART) initiation after AIDS diagnosis, in the absence of certain opportunistic infections such as tuberculosis and cryptococcal meningitis, delays disease progression and death, but system barriers to inpatient ART initiation at large hospitals in the era of modern ART have been less studied. We reviewed hospitalizations for persons newly diagnosed with AIDS at Grady Memorial Hospital in Atlanta, Georgia in 2011 and 2012. Individual- and system-level variables were collected. Logistic regression models were used to estimate the odds ratios (ORs) for ART initiation prior to discharge...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28198203/enteral-administration-of-twice-daily-dolutegravir-and-rilpivirine-as-a-part-of-a-triple-therapy-regimen-in-a-critically-ill-patient-with-hiv
#2
Sarah Lynn Turley, Patricia Pecora Fulco
The administration of antiretroviral therapy (ART) in intubated critically ill patients may be challenging. Limited pharmacokinetic data exist characterizing the effects of crushed ART with subsequent enteral administration on antiretroviral drug concentrations or the clinical impact on HIV virologic suppression. We report a case of a 27-year-old HIV-positive male with presumed multidrug-resistant HIV and a diagnosis of lymphoma who required enteral ART administration after intensive care unit admission. Crushed twice-daily dolutegravir (separated from enteral nutrition by 2 hours) and rilpivirine (concurrently with a bolus feed) were administered via an orogastric tube...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28176538/intimate-partner-violence-depression-and-quality-of-life-among-women-living-with-hiv-aids-in-a-coastal-city-of-south-india
#3
Basavaprabhu Achchappa, Mahak Bhandary, Bhaskaran Unnikrishnan, John T Ramapuram, Vaman Kulkarni, Satish Rao, Deepak Maadi, Anish Bhat, Shivani Priyadarshni
BACKGROUND: Intimate partner violence (IPV) is a severe form of abuse prevalent in urban and rural areas of India with its effects on mental and physical health of the person receiving it, leading to a poorer quality of life. METHODS: A cross-sectional study was conducted among 99 women living with HIV, and information was collected using abuse assessment scale. The data were entered and analyzed using SPSS version 17.0. RESULTS: The IPV was reported by 19...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28090799/national-hiv-care-continua-for-key-populations
#4
Somya Gupta, Reuben Granich
We reviewed published national HIV care continua for men who have sex with men (MSM), people who inject drugs (PWID), and female sex workers (FSWs) to track progress toward the 90-90-90 target. We searched the Internet, PubMed, surveillance reports, United Nations Programme on HIV/AIDS country reports, US President's Emergency Plan for AIDS Relief country/regional operational plans, and conference abstracts for the continua and graded them on quality. We found 12 continua for MSM, 7 for PWID, and 5 for FSW from 12 countries...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28088870/fatal-relapse-of-myelodysplastic-syndrome-in-a-patient-with-hiv-hepatitis-c-coinfection-treated-with-simeprevir-sofosbuvir
#5
Efemena Michael Diejomaoh, Joseph Clayton Gathe, Carl Craig Mayberry, John Benjamin Clemmons, Bernie Miguel, Alan Glombicki, Benjamin Daquioag
Registrational studies and observational cohorts clearly suggest sustained virologic response (SVR) rates in HIV-/hepatitis C-coinfected patients are similar to monoinfected patients when utilizing interferon-free regimens, and this can be accomplished with agents that are well tolerated with minimal adverse events. These randomized trials that led to the approval of several of our new direct-acting antiviral agents, however, specifically excluded patients who had significant comorbidities and none to our knowledge accepted patients with a history of cancer...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28088869/moving-from-public-health-failure-to-opportunity
#6
Reuben Granich, José M Zuniga
No abstract text is available yet for this article.
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28074681/community-based-exercise-in-the-context-of-hiv
#7
Anna Li, Taylor McCabe, Erin Silverstein, Stephanie Dragan, Nancy M Salbach, Mehdi Zobeiry, Sarah Beldick, Chris Godi, Kelly K O'Brien
OBJECTIVE: To identify factors to consider for developing and implementing a community-based exercise (CBE) program for people living with HIV (PLWH). METHODS: We conducted a qualitative descriptive study using semi-structured interviews with PLWH, rehabilitation professionals, and recreation providers from Canada and the United Kingdom. We asked participants to describe their experience with exercise, facilitators, and barriers to accessing and participating in exercise, and factors to consider in developing a CBE program for PLWH...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28071205/long-term-liver-diseases-after-initiation-of-antiretroviral-therapy-in-hiv-infected-patients-with-and-without-hbv-or-hcv-coinfection
#8
Sithakom Phusanti, Kwanhatai Manosudprasit, Somnuek Sungkanuparph
Coinfection of hepatitis B virus (HBV) or hepatitis C virus (HCV) with HIV is common and associated with increased mortality and increased risk of progression to chronic liver disease. We aimed to study long-term liver diseases after initiation of antiretroviral therapy (ART) in HIV-infected patients with and without HBV or HCV coinfection. A retrospective cohort of 92 patients (32 patients with HBV and/or HCV coinfection) was analyzed. Overall mean age was 38.3 years, and 54.3% were males. Immunological and virological responses were similar between the 2 groups ( P > ...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28050923/incidence-of-opportunistic-infections-among-hiv-positive-adults-on-highly-active-antiretroviral-therapy-in-a-teaching-hospital-india
#9
Nandita Shenoy, John T Ramapuram, Ashok Shenoy, Junaid Ahmed, N Srikant
Oral manifestations in HIV infections are numerous and some of these are acknowledged as being of great importance in the early diagnosis of the disease. Many HIV-associated oral infections occur early in HIV disease, not infrequently as the presenting sign or symptom. Thus, early detection of the associated oral opportunistic infections should, in many cases, result in earlier diagnosis of HIV infection. Cytology, a simple, painless, and inexpensive method, has become a preferred method and was used in our study for early diagnosis of certain lesions...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28043197/zidovudine-versus-tenofovir-based-antiretroviral-therapy-for-the-initial-treatment-of-hiv-infection-in-the-ethnic-minority-region-of-liangshan-prefecture-sichuan-province-china
#10
Cedric P Cheung, Wen Hong Lai, Jonathan Shuter
BACKGROUND: Tenofovir (TDF)-based highly active antiretroviral therapy (HAART), as recommended by the World Health Organization guidelines for HIV-naive patients, has been limited in resource-constrained settings. The aim of this study was to evaluate the effectiveness of zidovudine-(ZDV) versus TDF-based HAART in the Yi minority region of Sichuan Province, China at a single HIV treatment center. METHODS: The primary end point was the attainment of an HIV viral load <50 copies/mL...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28043196/clinico-epidemiological-profile-of-viral-sexually-transmitted-infections-in-seropositive-patients-attending-a-tertiary-care-hospital-in-north-india
#11
Shikha Chugh, Vijay Kumar Garg, Rashmi Sarkar, Kabir Sardana
Sexually transmitted diseases are a major public health problem both in developing and in developed countries, and especially with the co-synergy with HIV infection, there is an increasing need to have a proper understanding of the clinicodemographic patterns of sexually transmitted infections (STIs) for planning and implementing control strategies. Worldwide, there is an increased preponderance of viral STIs. Increasing incidence and altered clinical presentation of viral STIs in patients with HIV pose a diagnostic challenge; thereby, we studied the demographic profile of HIV-seropositive patients and compared clinical manifestations of viral STIs in HIV-seropositive patients to those in seronegative individuals...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28325131/text-message-reminder-recall-to-increase-hpv-immunization-in-young-hiv-1-infected-patients
#12
Susana Williams Keeshin, Judith Feinberg
HIV infected patients have higher rates of HPV infection, worse disease progression, increase severity of disease, and are at higher risk for intraepithelial neoplasia and cancer than their HIV negative counterparts. We conducted a yearlong pilot project to evaluate the impact of text message HPV immunization reminder-recall in young HIV-1 positive patients in a large urban academic HIV clinic. We found that text message reminder-recall improved HPV immunization uptake in a young, primarily black and un- or under-insured HIV-1 infected patients...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28325130/antiretroviral-adherence-perspectives-of-pregnant-and-postpartum-women-in-guyana
#13
Deborah Vitalis, Zelee Hill
The Caribbean region has the second highest HIV prevalence after Sub-Saharan Africa. Guyana's adult HIV prevalence is 1.9% among pregnant women, with women accounting for an estimated 58% of all persons living with HIV. However, there are few studies on ART adherence in the Caribbean, none from Guyana, and none focusing on adherence in pregnancy and the postpartum period. The objective of this study was to explore the perspectives of HIV-infected pregnant and postpartum women and healthcare providers in Guyana about barriers and facilitators to ART adherence...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/25331218/managing-the-personal-side-of-health-care-among-patients-with-hiv-aids
#14
Osaro Mgbere, Salma Khuwaja, Tanvir K Bell, Maria C Rodriguez-Barradas, Raouf Arafat, Janet M Blair, Ekere James Essien
The study describes the HIV care providers' sociodemographic and medical practice characteristics and the health care services offered to patients during medical care encounters in Houston/Harris County, Texas. We used data from the pilot cycle of the Centers for Disease Control and Prevention Medical Monitoring Project Provider Survey conducted in June to September 2009. The average age and HIV care experience of the providers were 46.7 and 11.7 years, respectively, and they provided care to an average of 113 patients monthly...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/24963087/hopefulness-fosters-affective-and-cognitive-constructs-for-actions-to-cope-and-enhance-quality-of-life-among-people-living-with-hiv-in-dar-es-salaam-tanzania
#15
Hellen Siril, Mary C Smith Fawzi, Jim Todd, Monique Wyatt, Japheth Kilewo, Norma Ware, Sylvia Kaaya
The aims of this study were to describe how people living with HIV (PLWH) perceive hope and illustrate implications for HIV care and treatment. This is a qualitative study done to explore perceptions and meanings of hope among PLWH attending care and treatment clinics in Dar es Salaam, Tanzania. In all, 10 focus group discussions and 9 in-depth interviews were conducted. People living with HIV described the following 3 dimensions of hope: cognitive, positive emotions, and normalization. Being cognizant of the effectiveness of antiretroviral treatment (ART) often led to positive emotions, such as feeling comforted or strengthened, which in turn was related to positive actions toward normalizing life...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/23422744/broadly-neutralizing-antibody-responses-in-a-subset-of-hiv-1-infected-individuals-in-chennai-india
#16
Syed Iqbal Hussain, Nandagopal Panneerselvam, Suniti Solomon, Sunil S Solomon, Kaavya Adam, Ezhilarasi Chandrasekaran, David C Montefiori, Balakrishnan Pachamuthu
Identification of broadly neutralizing antibodies (NAbs) generated during the course of HIV-1 infection is essential for effective HIV-1 vaccine design. The magnitude and breadth of neutralizing activity in the sera from 46 antiretroviral treatment-naive HIV-1 clade C-infected individuals was measured in a single round infection assay using TZM-bl cells and multisubtype panel of env-pseudotyped viruses. Higher levels of NAb response (NAb titer 500 to >40 000) were measured in these patients against tier 1 and tier 2 viruses...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28084190/depression-at-treatment-initiation-predicts-hiv-antiretroviral-adherence-in-uganda
#17
Glenn J Wagner, Mary Slaughter, Bonnie Ghosh-Dastidar
We examined the relationship between depression (symptom type, diagnostic severity, and change over time) and adherence to HIV antiretroviral therapy (ART) with data from 3 longitudinal studies (N = 1021) of patients starting ART in Uganda. The Patient Health Questionnaire was used to assess depressive symptoms (total score; somatic and cognitive subscales) and categorize severity level. At baseline, 9% had major depression and 30% had minor depression; 82% were adherent (reported no missed ART doses in the past 7 days) at month 6 and 85% at month 12...
January 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28084189/impact-of-unplanned-care-interruption-on-cd4-response-early-after-art-initiation-in-a-nigerian-cohort
#18
Aimalohi A Ahonkhai, Juliet Adeola, Bolanle Banigbe, Ifeyinwa Onwuatuelo, Abdulkabir B Adegoke, Ingrid V Bassett, Elena Losina, Kenneth A Freedberg, Prosper Okonkwo, Susan Regan
The authors conducted a retrospective cohort study of unplanned care interruption (UCI) among adults initiating antiretroviral therapy (ART) from 2009 to 2011 in a Nigerian clinic. The authors used repeated measures regression to model the impact of UCI on CD4 count upon return to care and rate of CD4 change on ART. Among 2496 patients, 83% had 0, 15% had 1, and 2% had ≥2 UCIs. Mean baseline CD4 for those with 0, 1, or ≥2 UCIs was 228/cells/mm(3), 355/cells/mm(3), and 392/cells/mm(3) ( P < .0001), respectively...
January 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/25331222/prevalence-of-hiv-associated-neurocognitive-disorder-hand-among-patients-attending-a-tertiary-health-facility-in-northern-nigeria
#19
Abdulkareem Jika Yusuf, Abdulaziz Hassan, Aisha Indo Mamman, Haruna Mohammed Muktar, Aishatu Maude Suleiman, Olusegun Baiyewu
BACKGROUND: HIV-associated neurocognitive disorder (HAND) is a great source of morbidity in sub-Saharan African region. However, the magnitude of this problem remains largely uninvestigated despite having the largest number of population with HIV/AIDS. The aim of this study is to determine the prevalence of HAND among patients attending a tertiary health facility in Nigeria. METHOD: We conducted a cross-sectional study among HIV-positive patients on antiretroviral therapy (ART) for at least 1 year...
January 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/21852689/substance-abuse-and-hiv-aids-in-the-caribbean
#20
Iliana Alexandra Angulo-Arreola, Francisco I Bastos, Steffanie A Strathdee
The Caribbean and Central America represent a formidable challenge for researchers and policy makers in the HIV field, due to their pronounced heterogeneity in terms of social, economic, and cultural contexts and the different courses the HIV epidemic has followed in the region. Such contrasting contexts and epidemics can be exemplified by 2 countries that share the island of Hispaniola, the French Creole-speaking Haiti, and the Spanish-speaking Dominican Republic. Haiti has experienced the worst epidemics outside of sub-Saharan Africa...
January 2017: Journal of the International Association of Providers of AIDS Care
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