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Journal of the International Association of Providers of AIDS Care

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https://www.readbyqxmd.com/read/28325131/text-message-reminder-recall-to-increase-hpv-immunization-in-young-hiv-1-infected-patients
#1
Susana Williams Keeshin, Judith Feinberg
HIV infected patients have higher rates of HPV infection, worse disease progression, increase severity of disease, and are at higher risk for intraepithelial neoplasia and cancer than their HIV negative counterparts. We conducted a yearlong pilot project to evaluate the impact of text message HPV immunization reminder-recall in young HIV-1 positive patients in a large urban academic HIV clinic. We found that text message reminder-recall improved HPV immunization uptake in a young, primarily black and un- or under-insured HIV-1 infected patients...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28325130/antiretroviral-adherence-perspectives-of-pregnant-and-postpartum-women-in-guyana
#2
Deborah Vitalis, Zelee Hill
The Caribbean region has the second highest HIV prevalence after Sub-Saharan Africa. Guyana's adult HIV prevalence is 1.9% among pregnant women, with women accounting for an estimated 58% of all persons living with HIV. However, there are few studies on ART adherence in the Caribbean, none from Guyana, and none focusing on adherence in pregnancy and the postpartum period. The objective of this study was to explore the perspectives of HIV-infected pregnant and postpartum women and healthcare providers in Guyana about barriers and facilitators to ART adherence...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28034344/factors-associated-with-delayed-enrollment-in-hiv-medical-care-among-hiv-positive-individuals-in-odessa-region-ukraine
#3
Oleksandr Neduzhko, Oleksandr Postnov, Ihor Perehinets, Jack DeHovitz, Michael Joseph, David Odegaard, Robert Kaplan, Tetiana Kiriazova
In Ukraine, about one-third of identified HIV-positive individuals are not connected to care. We conducted a cross-sectional survey (n = 200) among patients registered at Odessa AIDS centers in October to December 2011. Factors associated with delayed enrollment in HIV care (>3 months since positive HIV test) were evaluated using logistic regression. Among study participants (mean age 35 ± 8.2 years, 47.5% female, 42.5% reported history of injecting drugs), 55% delayed HIV care enrollment. Odds of delayed enrollment were higher for those with lower educational attainment (adjusted odds ratio [aOR]: 2...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/25331218/managing-the-personal-side-of-health-care-among-patients-with-hiv-aids
#4
Osaro Mgbere, Salma Khuwaja, Tanvir K Bell, Maria C Rodriguez-Barradas, Raouf Arafat, Janet M Blair, Ekere James Essien
The study describes the HIV care providers' sociodemographic and medical practice characteristics and the health care services offered to patients during medical care encounters in Houston/Harris County, Texas. We used data from the pilot cycle of the Centers for Disease Control and Prevention Medical Monitoring Project Provider Survey conducted in June to September 2009. The average age and HIV care experience of the providers were 46.7 and 11.7 years, respectively, and they provided care to an average of 113 patients monthly...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/24963087/hopefulness-fosters-affective-and-cognitive-constructs-for-actions-to-cope-and-enhance-quality-of-life-among-people-living-with-hiv-in-dar-es-salaam-tanzania
#5
Hellen Siril, Mary C Smith Fawzi, Jim Todd, Monique Wyatt, Japheth Kilewo, Norma Ware, Sylvia Kaaya
The aims of this study were to describe how people living with HIV (PLWH) perceive hope and illustrate implications for HIV care and treatment. This is a qualitative study done to explore perceptions and meanings of hope among PLWH attending care and treatment clinics in Dar es Salaam, Tanzania. In all, 10 focus group discussions and 9 in-depth interviews were conducted. People living with HIV described the following 3 dimensions of hope: cognitive, positive emotions, and normalization. Being cognizant of the effectiveness of antiretroviral treatment (ART) often led to positive emotions, such as feeling comforted or strengthened, which in turn was related to positive actions toward normalizing life...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/23422744/broadly-neutralizing-antibody-responses-in-a-subset-of-hiv-1-infected-individuals-in-chennai-india
#6
Syed Iqbal Hussain, Nandagopal Panneerselvam, Suniti Solomon, Sunil S Solomon, Kaavya Adam, Ezhilarasi Chandrasekaran, David C Montefiori, Balakrishnan Pachamuthu
Identification of broadly neutralizing antibodies (NAbs) generated during the course of HIV-1 infection is essential for effective HIV-1 vaccine design. The magnitude and breadth of neutralizing activity in the sera from 46 antiretroviral treatment-naive HIV-1 clade C-infected individuals was measured in a single round infection assay using TZM-bl cells and multisubtype panel of env-pseudotyped viruses. Higher levels of NAb response (NAb titer 500 to >40 000) were measured in these patients against tier 1 and tier 2 viruses...
March 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28399724/the-epidemiology-of-iris-in-southern-india-an-observational-cohort-study
#7
Nisha Thambuchetty, Kayur Mehta, Karthika Arumugam, Umadevi G Shekarappa, Jyothi Idiculla, Anita Shet
Immune reconstitution inflammatory syndrome (IRIS) is an uncommon but dynamic phenomenon seen among patients initiating antiretroviral therapy (ART). We aimed to describe incidence, risk factors, clinical spectrum, and outcomes among ART-naive patients experiencing IRIS in southern India. Among 599 eligible patients monitored prospectively between 2012 and 2014, there were 59.3% males, with mean age 36.6 ± 7.8 years. Immune reconstitution inflammatory syndrome incidence rate was 51.3 per 100 person-years (95% confidence interval: 44...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28393665/the-first-report-of-bartonella-quintana-immune-reconstitution-inflammatory-syndrome-complicated-by-jarisch-herxheimer-reaction
#8
Michelle DallaPiazza, Matthew Jiro Akiyama
Bacillary angiomatosis (BA) is a rare complication of human immune deficiency virus (HIV) infection in the post-antiretroviral therapy (ART) era, and few cases of BA-associated immune reconstitution inflammatory syndrome (IRIS) have been described. We report the case of a 50-year-old man who presented with mass lesions involving the skin, subcutaneous tissues, muscle, and bone. The diagnosis of Bartonella quintana BA was confirmed by serum polymerase chain reaction. The patient's treatment course was complicated by both IRIS and Jarisch-Herxheimer reaction...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28393664/use-of-placebo-pills-before-treatment-initiation-in-youth-with-hiv-are-they-ready
#9
Lisa M Ingerski, Megan L Wilkins, Amanda M Rach, Nehali Patel, Aditya H Gaur
Highly active antiretroviral therapy (HAART) nonadherence is related to negative health outcomes and is well-documented in adolescents and young adults (AYAs) with behaviorally acquired HIV. Few studies describe methods to improve adherence in this population. This retrospective study describes placebo pill trial use (ie, pills with inert substance prescribed to practice taking HAART) in AYAs initiating HAART and its relation to disease outcomes. Sixty-two AYAs initiated HAART during the review period. Disease outcomes during the first year of standard clinical care were abstracted from medical records...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28393663/herpes-simplex-virus-cytomegalovirus-and-pneumocystis-jiroveci-pneumonia-in-a-treatment-naive-hiv-positive-patient-with-pulmonary-alveolar-proteinosis-case-report
#10
Anita Bapat, Eliahu Bishburg, Sandhya Nagarakanti
Infection with multiple pathogens concurrently has become less common since the introduction of potent antiretroviral agent and effective prophylactic agents. We describe a patient with pulmonary alveolar proteinosis (PAP) admitted with pneumonia who was found to have AIDS and diagnosed with Pneumocystis jiroveci pneumonia, human herpesvirus type 1 (HHV-1), and a concomitant cytomegalovirus viremia. Polymerase chain reaction viral load was used for diagnosis of HHV-1 and follow-up. The patient was treated with trimethoprim-sulfamethoxazole and ganciclovir and had a resolution of pneumonia...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28393662/cholecalciferol-20-000-iu-once-weekly-in-hiv-positive-patients-with-low-vitamin-d-levels-result-from-a-cohort-study
#11
Sebastian Noe, Silke Heldwein, Rita Pascucchi, Celia Oldenbüttel, C Wiese, Ariane von Krosigk, Eva Jägel-Guedes, Hans Jäger, Wolfgang Mayer, Christoph D Spinner, Eva Wolf
PURPOSE: To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients. METHODS: Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this retrospective study. RESULTS: After 1 year of administration of cholecalciferol 20 000 IU weekly, about 78% of patients with initial vitamin D level <20 µg/L achieved vitamin D levels >20 µg/L and 42% achieved levels >30 µg/L...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28393661/persistence-of-macrocytosis-after-discontinuation-of-zidovudine-in-hiv-infected-patients
#12
Inski Yu, Richard N Greenberg, Timothy N Crawford, Alice C Thornton, Thein Myint
The duration of macrocytosis after stopping zidovudine (ZDV) is unknown. Among 104 HIV-infected patients treated with ZDV for more than 1 year, 84 patients had macrocytosis at ZDV discontinuation. The median mean corpuscular volume (MCV) was 114.6 fL (range 100-128 fL). Patients were divided into 2 groups: those who did (resolved macrocytosis, n = 36) and did not (persistent macrocytosis, n = 48) normalize MCV at 3 to 6 months after ZDV discontinuation. Alcohol use ( P = .02), smoking ( P = .03), and lower (but within normal range) folic acid levels ( P = ...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28367733/prevalence-and-correlates-of-probable-hiv-associated-dementia-in-hiv-outpatients-in-ho-chi-minh-city-vietnam
#13
Thanh Truc Thai, Mairwen K Jones, Lynne M Harris, Robert C Heard
This study identified prevalence and correlates of HIV-associated dementia (HAD) among people living with HIV (PLWHA) in Ho Chi Minh City, Vietnam. Four hundred PLWHA completed a self-report questionnaire and were interviewed by a trained researcher to assess HAD using the International HIV Dementia Scale (IHDS). Clinical information concerning HIV treatment was also extracted from medical records. The results indicate the prevalence of probable HAD based on IHDS score <10.5 was 39.8% (95% confidence interval [CI]: 35...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28198210/a-minority-of-patients-newly-diagnosed-with-aids-are-started-on-antiretroviral-therapy-at-the-time-of-diagnosis-in-a-large-public-hospital-in-the-southeastern-united-states
#14
Neela D Goswami, Jonathan Colasanti, Jonathan J Khoubian, Yijian Huang, Wendy S Armstrong, Carlos Del Rio
Prompt antiretroviral therapy (ART) initiation after AIDS diagnosis, in the absence of certain opportunistic infections such as tuberculosis and cryptococcal meningitis, delays disease progression and death, but system barriers to inpatient ART initiation at large hospitals in the era of modern ART have been less studied. We reviewed hospitalizations for persons newly diagnosed with AIDS at Grady Memorial Hospital in Atlanta, Georgia in 2011 and 2012. Individual- and system-level variables were collected. Logistic regression models were used to estimate the odds ratios (ORs) for ART initiation prior to discharge...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28198203/enteral-administration-of-twice-daily-dolutegravir-and-rilpivirine-as-a-part-of-a-triple-therapy-regimen-in-a-critically-ill-patient-with-hiv
#15
Sarah Lynn Turley, Patricia Pecora Fulco
The administration of antiretroviral therapy (ART) in intubated critically ill patients may be challenging. Limited pharmacokinetic data exist characterizing the effects of crushed ART with subsequent enteral administration on antiretroviral drug concentrations or the clinical impact on HIV virologic suppression. We report a case of a 27-year-old HIV-positive male with presumed multidrug-resistant HIV and a diagnosis of lymphoma who required enteral ART administration after intensive care unit admission. Crushed twice-daily dolutegravir (separated from enteral nutrition by 2 hours) and rilpivirine (concurrently with a bolus feed) were administered via an orogastric tube...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28176538/intimate-partner-violence-depression-and-quality-of-life-among-women-living-with-hiv-aids-in-a-coastal-city-of-south-india
#16
Basavaprabhu Achchappa, Mahak Bhandary, Bhaskaran Unnikrishnan, John T Ramapuram, Vaman Kulkarni, Satish Rao, Deepak Maadi, Anish Bhat, Shivani Priyadarshni
BACKGROUND: Intimate partner violence (IPV) is a severe form of abuse prevalent in urban and rural areas of India with its effects on mental and physical health of the person receiving it, leading to a poorer quality of life. METHODS: A cross-sectional study was conducted among 99 women living with HIV, and information was collected using abuse assessment scale. The data were entered and analyzed using SPSS version 17.0. RESULTS: The IPV was reported by 19...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28090799/national-hiv-care-continua-for-key-populations
#17
Somya Gupta, Reuben Granich
We reviewed published national HIV care continua for men who have sex with men (MSM), people who inject drugs (PWID), and female sex workers (FSWs) to track progress toward the 90-90-90 target. We searched the Internet, PubMed, surveillance reports, United Nations Programme on HIV/AIDS country reports, US President's Emergency Plan for AIDS Relief country/regional operational plans, and conference abstracts for the continua and graded them on quality. We found 12 continua for MSM, 7 for PWID, and 5 for FSW from 12 countries...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28088870/fatal-relapse-of-myelodysplastic-syndrome-in-a-patient-with-hiv-hepatitis-c-coinfection-treated-with-simeprevir-sofosbuvir
#18
Efemena Michael Diejomaoh, Joseph Clayton Gathe, Carl Craig Mayberry, John Benjamin Clemmons, Bernie Miguel, Alan Glombicki, Benjamin Daquioag
Registrational studies and observational cohorts clearly suggest sustained virologic response (SVR) rates in HIV-/hepatitis C-coinfected patients are similar to monoinfected patients when utilizing interferon-free regimens, and this can be accomplished with agents that are well tolerated with minimal adverse events. These randomized trials that led to the approval of several of our new direct-acting antiviral agents, however, specifically excluded patients who had significant comorbidities and none to our knowledge accepted patients with a history of cancer...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28088869/moving-from-public-health-failure-to-opportunity
#19
Reuben Granich, José M Zuniga
No abstract text is available yet for this article.
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28084190/depression-at-treatment-initiation-predicts-hiv-antiretroviral-adherence-in-uganda
#20
Glenn J Wagner, Mary Slaughter, Bonnie Ghosh-Dastidar
We examined the relationship between depression (symptom type, diagnostic severity, and change over time) and adherence to HIV antiretroviral therapy (ART) with data from 3 longitudinal studies (N = 1021) of patients starting ART in Uganda. The Patient Health Questionnaire was used to assess depressive symptoms (total score; somatic and cognitive subscales) and categorize severity level. At baseline, 9% had major depression and 30% had minor depression; 82% were adherent (reported no missed ART doses in the past 7 days) at month 6 and 85% at month 12...
January 2017: Journal of the International Association of Providers of AIDS Care
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