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African Journal of Laboratory Medicine

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https://www.readbyqxmd.com/read/30643735/need-for-better-adherence-to-optimal-incubation-temperature-for-quality-laboratory-diagnostics-and-antibiotic-resistance-monitoring
#1
Cristina Gutierrez, Akos Somoskovi, Kris Natarajan, David Bell
No abstract text is available yet for this article.
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30643734/antimicrobial-resistance-of-vibrio-cholerae-from-sub-saharan-africa-a-systematic-review
#2
REVIEW
Yahaya Mohammed, Aaron O Aboderin, Iruka N Okeke, Adebola T Olayinka
Background: The World Health Assembly adopted the Global Action Plan on Antimicrobial Resistance, which includes improving the knowledge base through surveillance and research. Noteworthily, the World Health Organization has advocated a Global Antimicrobial Resistance Surveillance System to address the plan's surveillance objective, with most African countries enrolling in or after 2017. Aim: The aim of this article was to review prior data on antimicrobial resistance of Vibrio cholerae from sub-Saharan Africa with a view for future control and intervention strategies...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568909/antimicrobial-resistance-surveillance-in-africa-successes-gaps-and-a-roadmap-for-the-future
#3
EDITORIAL
Samuel Kariuki, Karen H Keddy, Martin Antonio, Iruka N Okeke
No abstract text is available yet for this article.
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568908/antibiotic-resistance-trends-of-eskape-pathogens-in-kwazulu-natal-south-africa-a-five-year-retrospective-analysis
#4
Yogandree Ramsamy, Sabiha Y Essack, Benn Sartorius, Miriam Patel, Koleka P Mlisana
Background: To combat antimicrobial resistance, the World Health Organization developed a global priority pathogen list of antibiotic-resistant bacteria for prioritisation of research and development of new, effective antibiotics. Objective: This study describes a five-year resistance trend analysis of the ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp., from Kwazulu-Natal, South Africa...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568907/-clostridium-difficile-in-patients-attending-tuberculosis-hospitals-in-cape-town-south-africa-2014-2015
#5
Brian R Kullin, Sharon Reid, Valerie Abratt
Background: Diarrhoea due to Clostridium difficile infection (CDI) poses a significant burden on healthcare systems around the world. However, there are few reports on the current status of the disease in sub-Saharan Africa. Objectives: This study examined the occurrence of CDI in a South African population of tuberculosis patients, as well as the molecular epidemiology and antibiotic susceptibility profiles of C. difficile strains responsible for disease. Methods: Toxigenic C...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568906/africa-centres-for-disease-control-and-prevention-s-framework-for-antimicrobial-resistance-control-in-africa
#6
Jay K Varma, John Oppong-Otoo, Pascale Ondoa, Olga Perovic, Benjamin J Park, Ramanan Laxminarayan, Rosanna W Peeling, Constance Schultsz, Han Li, Chikwe Ihekweazu, Amadou A Sall, Baboucarr Jaw, John N Nkengasong
No abstract text is available yet for this article.
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568905/leveraging-donor-support-to-develop-a-national-antimicrobial-resistance-policy-and-action-plan-ghana-s-success-story
#7
Japheth A Opintan
Background: To mitigate the increasing trend of antimicrobial drug resistance (AMR), the Global Action Plan (GAP) on AMR was adopted at the 68th World Health Assembly in May 2015. Subsequently, member countries were encouraged to mirror the five key strategic objectives of GAP to develop their respective National Action Plans (NAPs) by 2017. Country-specific data on AMR is, however, critical for a comprehensive NAP that will inform policy and also anchor all the objectives of GAP. Systematic reviews have been suggested by some authors to generate relevant data to inform NAP development...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568904/diagnosis-of-rifampicin-resistant-tuberculosis-discordant-results-by-diagnostic-methods
#8
Winnie Mwanza, Deborah Milimo, Maureen M Chilufya, Nkatya Kasese, Maina C Lengwe, Stembiso Munkondya, Petra de Haas, Helen Ayles, Monde Muyoyeta
The performance of the Xpert© MTB/RIF and MTBDR plus assays for the detection of rifampicin resistant Mycobacterium tuberculosis was compared to culture-based drug susceptibility testing in 30 specimens with rifampicin-resistant and rifampicin-indeterminate Xpert MTB/RIF results collected between March 2012 and March 2014. Xpert MTB/RIF and MTBDR plus were 100% sensitive and 100% concordant for rifampicin resistance detection, but 3 of 13 samples (23%) positive for rifampicin resistance on Xpert MTB/RIF and MTBDR plus were negative for rifampicin resistance on mycobacteria growth indicator tube drug susceptibility testing...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568903/multi-drug-resistant-mycobacterium-tuberculosis-in-port-harcourt-nigeria
#9
Kome Otokunefor, Tosanwumi V Otokunefor, Godwin Omakwele
Background: In past years, much focus has been on tackling the scourge and spread of tuberculosis worldwide. The recent emergence of multi-drug resistant (MDR) tuberculosis has, however, negatively threatened progress made so far. Nigeria ranks fourth out of the 22 high tuberculosis burden countries in the world and has the highest burden of tuberculosis in Africa. It is therefore necessary to monitor the MDR tuberculosis situation in the country. Objectives: This study set out to assess the proportions of MDR tuberculosis in patients attending six directly observed treatment short-course centres in Port Harcourt, Nigeria, from October 2015 to October 2016...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568902/a-systematic-review-of-healthcare-associated-infections-in-africa-an-antimicrobial-resistance-perspective
#10
REVIEW
Emmanuel O Irek, Adewale A Amupitan, Temitope O Obadare, Aaron O Aboderin
Background: Healthcare-associated infection (HCAI) is a global health challenge, not only as an issue of patient safety but also as a major driver of antimicrobial resistance (AMR). It is a major cause of morbidity and mortality with economic consequences. Objective: This review provides an update on the occurrence of HCAI, as well as the contribution of emerging AMR on healthcare delivery in Africa. Methods: We searched PubMed, Cochrane database, African Journals Online and Google Scholar for relevant articles on HCAI in Africa between 2010 and 2017...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568901/differential-infectivity-of-gametocytes-after-artemisinin-based-combination-therapy-of-uncomplicated-falciparum-malaria
#11
Dinkorma T Ouologuem, Cheick O Kone, Bakary Fofana, Bakary Sidibe, Amadou H Togo, Demba Dembele, Sekou Toure, Sekou Koumare, Ousmane Toure, Issaka Sagara, Abdoulaye Toure, Adama Dao, Ogobara K Doumbo, Abdoulaye A Djimde
Background: Most malaria-endemic countries use artemisinin-based combination therapy (ACT) as their first-line treatment. ACTs are known to be highly effective on asexual stages of the malaria parasite. Malaria transmission and the spread of resistant parasites depend on the infectivity of gametocytes. The effect of the current ACT regimens on gametocyte infectivity is unclear. Objectives: This study aimed to determine the infectivity of gametocytes to Anopheles gambiae following ACT treatment in the field...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568900/drug-resistant-tuberculosis-in-africa-current-status-gaps-and-opportunities
#12
Nazir Ismail, Farzana Ismail, Shaheed V Omar, Linsay Blows, Yasmin Gardee, Hendrik Koornhof, Philip C Onyebujoh
Background: The World Health Organization End TB Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. Objective: We sought to review the current status of drug resistant tuberculosis in Africa and highlight key areas requiring improvement. Methods: Available data from 2016 World Health Organization global tuberculosis database were extracted and analysed using descriptive statistics...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568899/the-role-of-connected-diagnostics-in-strengthening-regional-national-and-continental-african-disease-surveillance
#13
Natasha M Gous, Philip C Onyebujoh, Alash'le Abimiku, Chris Macek, Jeff Takle
No abstract text is available yet for this article.
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568898/antimicrobial-resistance-surveillance-in-ethiopia-implementation-experiences-and-lessons-learned
#14
Rajiha A Ibrahim, Amete M Teshal, Surafel F Dinku, Negga A Abera, Abebe A Negeri, Feven G Desta, Eyasu T Seyum, Adugna W Gemeda, Wubshet M Keficho
Introduction: Antimicrobial resistance (AMR) poses a global threat. High levels of AMR to commonly used antibiotics have been reported in East Africa. A situation analysis of AMR in Ethiopia also indicated high resistance levels. To prevent and contain AMR, Ethiopia established a national surveillance network. Objectives: This article describes the steps taken to prioritise AMR and establish the National Antimicrobial Resistance Surveillance System in Ethiopia, as well as present the challenges and lessons learned through implementation...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568897/antimicrobial-resistance-surveillance-with-whole-genome-sequencing-in-africa-it-s-about-time
#15
Hajo Grundmann, Hellen Gelband
No abstract text is available yet for this article.
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568896/an-overview-of-antimicrobial-resistance-surveillance-among-healthcare-associated-pathogens-in-south-africa
#16
REVIEW
Ashika Singh-Moodley, Husna Ismail, Olga Perovic
Healthcare-associated infections are a serious public health concern resulting in morbidity and mortality particularly in developing countries. The lack of information from Africa, the increasing rates of antimicrobial resistance and the emergence of new resistance mechanisms intensifies this concern warranting the need for vigorous standardised surveillance platforms that produce reliable and accurate data which can be used for addressing these concerns. The implementation of national treatment guidelines, policies, antimicrobial stewardship programmes and infection prevention and control practices within healthcare institutions require a platform from which it can draw information and direct its approach...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568895/building-resources-to-meet-evolving-laboratory-medicine-challenges-in-africa
#17
EDITORIAL
Iruka N Okeke
No abstract text is available yet for this article.
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568894/ecthyma-gangrenosum-on-the-face-of-a-malnourished-child-with-pseudomonas-sepsis-simulating-cancrum-oris
#18
Khadijat O Isezuo, Usman M Sani, Usman M Waziri, Bilkisu I Garba, Yahaya Mohammed, Joy F Legbo, Nazish P Aquil, Fatima I Abubakar, Memuna Omar
Introduction: Ecthyma gangrenosum (EG) is a cutaneous lesion commonly caused by Pseudomonas aeruginosa that involves mainly the lower limbs and gluteal region, seen more in immunosuppressed patients with neutropenia. Cancrum oris (Noma) is a gangrenous necrosis of the face that begins as a gingival ulcer and progresses rapidly to destroy contiguous tissues in malnourished children. Case Presentation: This article reports a case of facial EG which was similar to Noma in a malnourished child: a 16-month old girl with fever, cough, weight loss, watery stool and swelling on right cheek...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568893/assessment-of-international-consensus-group-for-haematology-smear-review-rules-among-patients-with-plasmodium-falciparum-malaria-in-johannesburg-south-africa
#19
Jenifer L Vaughan, Nazeer Alli, Sandra Havyarimana, Estee Benade
A peripheral blood smear review is a useful but labour intensive adjunct to the full blood count and differential count. In this study, we retrospectively evaluated the performance of the International Consensus Group for Haematology smear review rules for detection of malaria in 153 samples with Plasmodium falciparum parasitaemia. Review rules were triggered in 132 (86.3%) samples, including all patients with severe malaria. Of the 21 false negative samples, 14 (66.7%) had haemoglobin values ≥ 10g/dl and platelets > 120x109 /l...
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/30568892/evaluation-of-standard-diagnostic-rapid-test-kits-for-malaria-diagnosis-among-hiv-patients-in-kano-nigeria
#20
Henry A Mbah, Feyisayo E Jegede, Surajudeen A Abdulrahman, Tinuade I Oyeyi
Background: Malaria diagnosis among HIV-positive patients is uncommon in Nigeria despite the high burden of both diseases. Objectives: We evaluated the performance of a malaria rapid diagnostic test (MRDT) against blood smear microscopy (BSM) among HIV-positive patients in relation to anti-retroviral treatment (ART) status, CD4+ count, fever, cotrimoxazole prophylaxis and malaria density count. Method: A cross-sectional study involving 1521 consenting randomly selected HIV-positive adults attending two ART clinics in Kano, Nigeria, between June 2015 and May 2016...
2018: African Journal of Laboratory Medicine
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