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Urolithiasis

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https://www.readbyqxmd.com/read/29777258/development-of-a-two-stage-in-vitro-model-system-to-investigate-the-mineralization-mechanisms-involved-in-idiopathic-stone-formation-stage-1-biomimetic-randall-s-plaque-using-decellularized-porcine-kidneys
#1
Archana C Lovett, Saeed R Khan, Laurie B Gower
Idiopathic calcium oxalate (CaOx) stone formers form stones that are commonly attached to calcium phosphate (CaP) deposits in the renal tissue, known as Randall's plaques (RP). Plaques are suggested to originate in the renal tubular basement membrane, where they exhibit a morphology of concentrically laminated apatitic spherules, while in the interstitial regions, the collagen fibrils and vesicles become mineralized. We hypothesize that these minerals might form by non-classical crystallization mechanisms, such as via amorphous precursors, some of which might originate from a polymer-induced liquid-precursor (PILP) process...
May 18, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29700572/long-term-effects-of-anatrophic-nephrolithotomy-on-selective-renal-function
#2
Ahmed R El-Nahas, Amr A Elsawy, Ahmed Abdelhalim, Mohamed M Elsaadany, Yasser Osman
To evaluate the long-term changes of selective renal function after anatrophic nephrolithotomy (ANL). A retrospective study was conducted for patients who underwent ANL between January 1995 and December 2016. Inclusion criteria were availability of preoperative and follow-up (1 year or more) radio-isotopic renal scans. Stone-free status was evaluated after 1 month with KUB and ultrasonography or NCCT. Renal isotope scans using 99mTc MAG3 were performed to measure the changes in selective function of the affected kidney (GFR%)...
April 26, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29696300/journey-of-a-cystinuric-patient-with-a-long-term-follow-up-from-a-medical-stone-clinic-necessity-to-be-safer-stone-and-fragments-entirely-removed
#3
Sacha L Moore, Bhaskar K Somani, Paul Cook
There is a lack of studies looking at the longitudinal follow-up of patients with cystine stones. We wanted to assess the journey of cystinuric patients through our specialist metabolic stone clinic to improve the understanding of episodes, interventions and current outcomes in this patient cohort. After ethical approval, all patients who attended our metabolic stone clinic from 1994 to 2014 with at least one cystine stone episode were included in our study. Data were retrospectively analysed for patient demographics, stone episodes or intervention, clinical parameters and patient compliance...
April 25, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29619532/in-memory-of-professor-loris-borghi-1949-2018
#4
EDITORIAL
Giovanni Gambaro, Alberto Trinchieri
No abstract text is available yet for this article.
April 4, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29557487/effect-of-transcutaneous-electrical-acupoint-stimulation-on-postoperative-analgesia-after-ureteroscopic-lithotripsy-a-randomized-controlled-trial
#5
Qing Tu, Jianhui Gan, Jinlin Shi, Hong Yu, Shuangliang He, Jian Zhang
Transcutaneous electrical acupoint stimulation (TEAS) is an effective analgesic measure. We studied the analgesic effect of TEAS by applying it alone after ureteroscopic lithotripsy, rather than applying it as a supplementary analgesic measure. Participants (n = 120) scheduled to undergo ureteroscopic holmium laser lithotripsy, were enrolled and randomly assigned into Group T (TEAS n = 60) and Group C (Control, n = 60). The participants in Group T were treated with TEAS for postoperative analgesia...
March 20, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29549382/mini-vs-standard-percutaneous-nephrolithotomy-for-renal-stones-a-comparative-study
#6
Mohammed S ElSheemy, Akram A Elmarakbi, Mohammed Hytham, Hamdy Ibrahim, Sanjay Khadgi, Ahmed M Al-Kandari
To compare the outcome of mini-percutaneous nephrolithotomy (Mini-PNL) versus standard-PNL for renal stones. Retrospective study was performed between March 2010 and May 2013 for patients treated by Mini-PNL or standard-PNL through 18 and 30 Fr tracts, respectively, using pneumatic lithotripsy. Semirigid ureteroscope (8.5/11.5 Fr) was used for Mini-PNL and 24 Fr nephroscope for standard-PNL. Both groups were compared in stone free rate(SFR), complications and operative time using Student-t, Mann-Whitney, Chi square or Fisher's exact tests as appropriate in addition to logistic regression analysis...
March 16, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29549381/polymorphisms-of-the-vdr-gene-in-patients-with-nephrolithiasis-in-a-han-chinese-population
#7
Zhenxing Yang, Qingqing Wang, Jiang F Zhong, Longkun Li
An association study between VDR gene polymorphisms and nephrolithiasis was conducted in different populations, but it is not yet known whether the association exists in the Han Chinese population. Here, we genotyped three SNPs (rs731236, rs7975232 and rs10735810) in the promoter region of the VDR gene by iMLDR genotyping assays in a large case-control cohort. The results demonstrated that there was no association found between the three SNPs (rs731236, rs7975232 and rs10735810) in the VDR gene and nephrolithiasis, whether in allele or genotype distribution...
March 16, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29511793/calcifying-nanoparticles-induce-cytotoxicity-mediated-by-ros-jnk-signaling-pathways
#8
Jihua Wu, Zhiwei Tao, Yaoliang Deng, Quan Liu, Yunlong Liu, Xiaofeng Guan, Xiang Wang
Calcifying nanoparticles (CNPs) play an important role in kidney stone formation, but the mechanism(s) are unclear. CNPs were isolated and cultured from midstream urine of patients with kidney stones. CNP morphology and characteristics were examined by electron microscopy and electrophoresis analysis. Chemical composition was analyzed using energy-dispersive X-ray microanalysis and Western blotting. Human renal proximal convoluted tubule cell (HK-2) cultures were exposed to CNPs for 0, 12 and 72 h, and production of reactive oxygen species (ROS), mitochondrial membrane potential and apoptosis levels were evaluated...
March 6, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29504067/electron-probe-micro-analysis-reveals-the-complexity-of-mineral-deposition-mechanisms-in-urinary-stones
#9
Muhammed A P Manzoor, M Mujeeburahiman, Punchappady-Devasya Rekha
Urinary stones are complex mineralogical formations in the urinary system often impairing the kidney function. Several studies have attempted to understand the mechanisms of stone formation and growth; however, it remains to be fully explored. Here, we present a detailed investigation on the morphological and mineralogical characterizations of urinary stones. Structural properties of different types of urinary stones were done by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and field-emission scanning electron microscope (FE-SEM) analyses...
March 5, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29500620/three-dimensional-evaluation-of-perirenal-fat-volume-in-patients-with-nephrolithiasis
#10
Daniel J Lama, Shoaib Safiullah, Albert Yang, Zhamshid Okhunov, Jaime Landman, Ralph V Clayman
The concept of adipose tissue as an organ unto itself represents a new medical construct; already differences in the volume of perirenal fat around a tumor-bearing kidney have been described. We hypothesized that renal calculi may have similar impact on perirenal fat or alternatively abnormalities in urinary metabolites may be the result of perirenal fat affecting renal metabolism and subsequent stone formation. Accordingly, we conducted a study utilizing three-dimensional imaging software to evaluate perirenal fat volume (PFV) in patients with nephrolithiasis...
March 2, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29497768/the-all-seeing-needle-micro-pcnl-versus-flexible-ureterorenoscopy-for-lower-calyceal-stones-of-%C3%A2-2-cm
#11
Kehua Jiang, Hongbo Chen, Xiao Yu, Zhiqiang Chen, Zhangqun Ye, Huixing Yuan
The objectives of the study are to compare the safety and efficacy of "all-seeing needle" optical puncture system micro-percutaneous nephrolithotomy (micro-PCNL) and flexible ureterorenoscopy (FURS) for the treatment of lower calyceal stones of ≤ 2 cm and to determine the advantages and disadvantages of each. 116 patients in total with lower calyceal stones of ≤ 2 cm were randomly divided into two equal groups, "all-seeing needle" optical puncture system micro-PCNL and FURS. In both groups, holmium laser was utilized for lithotripsy...
March 1, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29492591/uric-acid-stones-increase-the-risk-of-chronic-kidney-disease
#12
Ching-Chia Li, Tsu-Ming Chien, Wen-Jeng Wu, Chun-Nung Huang, Yii-Her Chou
The aim of this study was to compare the clinical characteristics of uric acid stones and their potential risk for chronic kidney disease (CKD). A total of 401 patients (196 with uric acid stone and 205 without) were enrolled from our database of patients with urolithiasis. We analyzed the clinical demographic features, stone location, urine chemistries, and renal function. There was a significant difference (p < 0.001) between the two groups in terms of age, with the higher mean age in the uric acid group...
February 28, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29484468/results-of-minimally-invasive-surgical-treatment-of-allograft-lithiasis-in-live-donor-renal-transplant-recipients-a-single-center-experience-of-3758-renal-transplantations
#13
Mehmet Sarier, Ibrahim Duman, Yucel Yuksel, Sabri Tekin, Meltem Demir, Fatih Arslan, Osman Ergun, Alim Kosar, Asuman Havva Yavuz
Allograft lithiasis is a rare urologic complication of renal transplantation (RT). Our aim is to present our experience with minimally invasive surgical treatment of allograft lithiasis in our series of live-donor renal transplant recipients. In a retrospective analysis of 3758 consecutive live-donor RTs performed in our center between November 2009 and January 2017, the results of minimally invasive surgery for the treatment of renal graft lithiasis diagnosed at follow-up were evaluated. Twenty-two (0.58%) patients underwent minimally invasive surgery for renal graft lithiasis...
February 26, 2018: Urolithiasis
https://www.readbyqxmd.com/read/28660284/primary-hyperoxaluria-in-populations-of-pakistan-origin-results-from-a-literature-review-and-two-major-registries
#14
REVIEW
Jamsheer Jehangir Talati, Sally-Anne Hulton, Sander F Garrelfs, Wajahat Aziz, Shoaib Rao, Amanullah Memon, Zafar Nazir, Raziuddin Biyabani, Saqib Qazi, Iqbal Azam, Aysha Habib Khan, Jamil Ahmed, Lena Jafri, Mohammad Zeeshan
Primary hyperoxalurias (PH) are devastating, autosomal recessive diseases causing renal stones. Undifferentiated hyperoxaluria is seen in up to 43% of Pakistani paediatric stone patients. High rates of consanguinity in Pakistan suggest significant local prevalence. There is no detailed information regarding number of cases, clinical features, and genetics in Pakistan-origin (P-o) patients. We reviewed available information on P-o PH patients recorded in the literature as well as from two major PH registries (the Rare Kidney Stone Consortium PH Registry (RKSCPHR) and the OxalEurope PH Registry (OxER); and the Aga Khan University Hospital in Pakistan...
April 2018: Urolithiasis
https://www.readbyqxmd.com/read/28624896/how-can-the-operation-time-be-shortened-by-reducing-the-tract-size
#15
LETTER
Kadir Yildirim, Namik Kemal Hatipoglu
No abstract text is available yet for this article.
April 2018: Urolithiasis
https://www.readbyqxmd.com/read/28623397/different-effects-of-%C3%AE-linolenic-acid-gla-supplementation-on-plasma-and-red-blood-cell-phospholipid-fatty-acid-composition-and-calcium-oxalate-kidney-stone-risk-factors-in-healthy-subjects-from-two-race-groups-with-different-risk-profiles-pose-questions-about
#16
Allen L Rodgers, Dalielah Jappie-Mahomed, Paul J van Jaarsveld
Fatty acid (FA) composition of phospholipids in plasma and red blood cells (RBC) can influence calciuria, oxaluria and renal stone formation. In this regard, the ratio of arachidonic acid (AA) and its precursor linoleic acid (LA) appears to be important. Administration of γ-linolenic acid (GLA) has been shown to increase the concentration of dihomo-gamma linoleic acid (DGLA) relative to AA indicating that it may attenuate biosynthesis of the latter. Such effects have not been investigated in race groups having difference stone occurrence rates...
April 2018: Urolithiasis
https://www.readbyqxmd.com/read/28616648/protective-effect-of-dietary-polyphenol-caffeic-acid-on-ethylene-glycol-induced-kidney-stones-in-rats
#17
Fauzia Yasir, Atia-Tul- Wahab, M Iqbal Choudhary
Dietary polyphenol caffeic acid (1) has been reported for various pharmacological activities. The aim of the current study was to investigate the effect of caffeic acid (1) on ethylene glycol-induced renal stones in rats. For the study, male Wistar rats were divided into seven groups; normal, pathological, and standard drug controls, and preventive and curative groups. Normal control group received drinking water for 8 weeks. Pathological, standard drug, preventive, and curative groups received 0.75% ethylene glycol in drinking water for the induction of calcium oxalate stone formation, along with the regular diet...
April 2018: Urolithiasis
https://www.readbyqxmd.com/read/28405703/metabolic-syndrome-contributes-to-renal-injury-mediated-by-hyperoxaluria-in-a-murine-model-of-nephrolithiasis
#18
Javier Sáenz-Medina, E Jorge, C Corbacho, M Santos, A Sánchez, P Soblechero, E Virumbrales, E Ramil, M J Coronado, I Castillón, D Prieto, J Carballido
Metabolic syndrome (MS) individuals have a higher risk of developing chronic kidney disease through unclear pathogenic mechanisms. MS has been also related with higher nephrolithiasis prevalence. To establish the influence of MS on renal function, we designed a murine model of combined metabolic syndrome and hyperoxaluria. Four groups of male Sprague-Dawley rats were established: (1) control group (n = 10) fed with standard chow; (2) stone former group (SF) (n = 10) fed with standard chow plus 0.75% ethylene glycol administered in the drinking water; (3) metabolic syndrome group (MS) (n = 10), fed with 60% fructose diet; (4) metabolic syndrome + stone former group (MS + SF) (n = 10), 60% fructose diet and 0...
April 2018: Urolithiasis
https://www.readbyqxmd.com/read/28365782/role-of-silodosin-as-medical-expulsive-therapy-in-ureteral-calculi-a-meta-analysis-of-randomized-controlled-trials
#19
Xin-Jian Liu, Jian-Guo Wen, You-Dong Wan, Bo-Wen Hu, Qing-Wei Wang, Yan Wang
The objective of this study is to investigate the efficacy of silodosin in medical expulsive therapy (MET) for ureteral stones. We conducted a systematic review and meta-analysis to determine the efficacy and safety of silodosin in MET for ureteral calculi. We searched PubMed, Embase, Medline, Central (the Cochrane Library, Issue 1,2013), Google Scholar from the inception to March 2015 for randomized controlled trials (RCTs), comparing silodosin with tamsulosin or control on ureteral stone passage. Eight RCTs with a total of 1145 ureteral stone patients (300 patients in the control group, 287 patients in the tamsulosin group, 558 patients in the silodosin group) were included in this meta-analysis...
April 2018: Urolithiasis
https://www.readbyqxmd.com/read/28357452/determinants-of-health-related-quality-of-life-for-patients-after-urinary-lithotripsy-ureteroscopic-vs-shock-wave-lithotripsy
#20
Shuzo Hamamoto, Rei Unno, Kazumi Taguchi, Taku Naiki, Ryosuke Ando, Atsushi Okada, Takaaki Inoue, Shinsuke Okada, Mostafa AbdelRazek, Kenjiro Kohri, Takahiro Yasui
PURPOSE: To compare the longitudinal health-related quality of life (HRQoL) after surgical intervention with ureteroscopic lithotripsy (URSL) and shock wave lithotripsy (SWL) and to evaluate the factors affecting HRQoL in urolithiasis patients. METHODS: A total of 262 patients who underwent lithotripsy (SWL, n = 61; URSL, n = 201) for upper urinary tract calculi treatment between June 2012 and January 2015 were evaluated. All patients were administered the Short-Form 36-item survey (SF-36) to assess HRQoL at four timepoints: before surgery, on the day of discharge, and 1 and 6 months after lithotripsy...
April 2018: Urolithiasis
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