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Urolithiasis

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https://www.readbyqxmd.com/read/27904915/studies-using-a-porcine-model-what-insights-into-human-calcium-oxalate-stone-formation-mechanisms-has-this-model-facilitated
#1
REVIEW
Kristina L Penniston, Sutchin R Patel, Denise J Schwahn, Stephen Y Nakada
Animal models are useful in the study of many human diseases. Our current understanding of the biological, physiological, and biochemical aspects of hyperoxaluria and calcium oxalate urolithiasis has been greatly informed by studies using animals. Recently, limitations in the extrapolation to humans of research results derived from laboratory rodents have been identified. The use in biomedical research of a variety of organisms, including large animals, is increasingly encouraged. The purpose of this article is to review the use of pigs in biomedical and stone research, to provide a rationale for using pigs in metabolic stone research, and to describe our 8-year experience in developing a porcine platform for studying hyperoxaluria and calcium oxalate urolithiasis...
November 30, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27900407/do-inhibitors-of-crystallisation-play-any-role-in-the-prevention-of-kidney-stones-a-critique
#2
REVIEW
William G Robertson
A critical examination of data in the literature and in as yet unpublished laboratory records on the possible role of so-called inhibitors of crystallisation in preventing the formation of calcium-containing kidney stones leads to the following conclusions. So-called inhibitors of spontaneous "self-nucleation" are unlikely to play any role in the initiation of the crystallisation of CaOx or CaP in urine because excessive urinary supersaturation of urine with respect to these salts dominates the onset of "self-nucleation" within the normal time frame of the transit of tubular fluid through the nephron (3-4 min)...
November 29, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27900406/what-does-the-crystallography-of-stones-tell-us-about-their-formation
#3
REVIEW
Peter Rez
The mineral phase makes up most of the mass of a kidney stone. Minerals all come in the form of crystals that are regular arrangements of atoms or molecular groupings at the atomic scale, bounded macroscopically by well-defined crystal faces. Pathologic nephroliths are a polycrystalline aggregate of submicron crystals. Organic macromolecules clearly have an important role in either promoting or preventing aggregation and in altering the morphology of individual submicron crystals by influencing the surface energies of different faces...
November 29, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27896392/tubular-and-genetic-disorders-associated-with-kidney-stones
#4
REVIEW
Nilufar Mohebbi, Pietro Manuel Ferraro, Giovanni Gambaro, Robert Unwin
This concise review summarizes our current understanding and the recent developments in genetics and related renal tubular disorders that have been linked with, or have been shown to be causal in, renal stone disease. The aim is to provide a readily accessible quick and easy update for urologists, nephrologists and endocrine or metabolic physicians whose practice involves the diagnosis and management of nephrolithiasis. An important message is to always consider a seemingly rare, and usually genetic, cause of kidney stones, since some of these are emerging as more common than originally thought, especially in adult clinical practice in which a family history of stones is a common finding...
November 28, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27896391/histological-aspects-of-the-fixed-particle-model-of-stone-formation-animal-studies
#5
REVIEW
Saeed R Khan
Crystallization by itself is not harmful as long as the crystals are not retained in the kidneys and are allowed to pass freely down the renal tubules to be excreted in the urine. A number of theories have been proposed, and studies performed, to determine the mechanisms involved in crystal retention within the kidneys. It has been suggested that urinary transit through the nephron is too fast for crystals to grow large enough to be retained. Thus, free particle mechanism alone cannot lead to stone formation, and there must be a mechanism for crystal fixation within the kidneys...
November 28, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27885408/erratum-to-a-novel-cyp24a1-genotype-associated-to-a-clinical-picture-of-hypercalcemia-nephrolithiasis-and-low-bone-mass
#6
Pietro Manuel Ferraro, Angelo Minucci, Aniello Primiano, Elisa De Paolis, Jacopo Gervasoni, Silvia Persichilli, Alessandro Naticchia, Ettore Capoluongo, Giovanni Gambaro
No abstract text is available yet for this article.
November 24, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27882414/systemic-endothelial-function-measured-by-flow-mediated-dilation-is-impaired-in-patients-with-urolithiasis
#7
Esin Yencilek, Hakan Sarı, Faruk Yencilek, Ezgi Yeşil, Hasan Aydın
Some in vitro and animal studies have shown endothelial dysfunction in hyperoxaluria models indicating its role in pathogenesis of urolithiasis and relation to CVD. The aim of this study was to investigate endothelial function in patients with urolithiasis in relation to urinary stone risk factors and metabolic parameters. A total of 120 subjects without any known CVD (60 with urolithiasis and 60 healthy subjects) were included into study. Fasting blood and 24-h urine samples were collected to study metabolic parameters (glucose and lipids) and urine stone risk factors (oxalate, citrate, uric acid, and calcium, pH)...
November 23, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27878331/fluoroscopy-versus-ultrasound-for-image-guidance-during-percutaneous-nephrolithotomy-a-systematic-review-and-meta-analysis
#8
REVIEW
Qiang Liu, Liang Zhou, Xiang Cai, Tao Jin, Kunjie Wang
This meta-analysis aims to compare the safety and efficacy of fluoroscopy versus ultrasound guidance during the access to the renal collecting system. A systematic literature review was performed in September 2016. Outcomes were explored using review manager v5.0. 18 studies with 2919 patients were included in the final analysis. There was no significant difference in stone-free rate (RR: 1.0; 95% CI, 0.98 to 1.05; p = 0.41), operation time (MD: 1.75; 95% CI, -9.15 to 12.65; p = 0.75), hospital stay (MD: -1...
November 22, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27864591/comparison-of-s-t-o-n-e-and-croes-nephrolithometry-scoring-systems-for-predicting-stone-free-status-and-complication-rates-after-percutaneous-nephrolithotomy-a-single-center-study-with-262-cases
#9
Serkan Yarimoglu, Salih Polat, Ibrahim Halil Bozkurt, Tarık Yonguc, Ozgu Aydogdu, Erhan Aydın, Tansu Degirmenci
The aim of this study was to compare the accuracy of the CROES nephrolithometric nomogram and S.T.O.N.E. scoring system in predicting PCNL outcomes in terms of stone-free rate, estimated blood loss (EBL), operative time (OR), length of hospital stay (LOS), and complications. Patients who underwent PCNL for renal stones between May 2012 and January 2015 were analyzed retrospectively. The patients' demographic characteristics and operational features were recorded prospectively in all patients postoperatively...
November 18, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27837249/analysis-of-repeated-renal-arteriography-after-percutaneous-nephrolithotomy
#10
He Zhaohui, Lei Hanqi, Lu Xiongbing, Zhang Caixia, Wan Shawpong, Zeng Guohua
To review the clinical data of the patients who required repeated renal arteriography following initial super-selective renalartery embolization (SRAE) after Percutaneous Nephrolithotomy (PCNL) and to analyze the reasons for the failure. We retrospectively reviewed the data of the patients who underwent repeat renal arteriography after PCNL for persistent or recurrent severe hemorrhage from August 2001 through August 2015 at our hospital. Total of 427 SRAEs were performed in 369 patients who had undergone PCNL...
November 11, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27837248/nephrolithiasis-as-a-risk-factor-of-chronic-kidney-disease-a-meta-analysis-of-cohort-studies-with-4-770-691-participants
#11
Meng Zhe, Zheng Hang
The objective of the study was to investigate the association between nephrolithiasis and the risk of chronic kidney disease (CKD). PubMed, Embase and ScienceDirect databases were searched for relevant cohort studies. A meta-analysis was conducted by pooling data from these studies via an inverse variance method. The Q statistic and I (2) were used to measure heterogeneity. Sensitivity analysis was conducted to ascertain whether the results were stable. Nine studies with eight cohorts involving 4,770,691 participants were identified...
November 11, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27837247/prognostic-utility-of-seasonal-changes-for-diagnosis-of-ureteral-stones
#12
LETTER
Hiroki Fukuhara, Osamu Ichiyanagi, Hiroshi Kakizaki, Norihiko Tsuchiya
No abstract text is available yet for this article.
November 11, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27822582/are-there-any-predictors-of-pyonephrosis-in-patients-with-renal-calculus-disease
#13
Madhusudan Patodia, Apul Goel, Vishwajeet Singh, Bhupendra Pal Singh, Rahul Janak Sinha, Manoj Kumar, Divakar Dalela, Satya Narayan Sankhwar
The objective of the study is to identify factors predicting development of pyonephrosis in patients of renal calculus disease (RCD), as this knowledge is largely unknown. Patients of RCD without pyonephrosis (Group 1) or with pyonephrosis (Group 2) presenting between December 2013 and November 2015 were evaluated. All patients of RCD who had undergone either percutaneous nephrostomy (PCN) or surgical management (percutaneous nephrolithotomy/pyelolithotomy/nephrectomy) were included. Patients treated conservatively, by extracorporeal shock-wave lithotripsy and patients of bilateral RCD were excluded...
November 7, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27787615/neutrophil-gelatinase-associated-lipocalin-ngal-value-changes-before-and-after-shock-wave-lithotripsy
#14
Matteo Vittori, Silvia Baroni, Pietro Manuel Ferraro, Giovanni Gambaro, Renato Morelli, PierFrancesco Bassi, Alessandro D'Addessi
Our aim was to determine short and medium-term changes of neutrophil gelatinase-associated lipocalin (NGAL) in the urine of patients undergoing shock wave lithotripsy (SWL). In patients with kidney stones, serum urea and creatinine (Cr), urine Cr and NGAL levels were determined immediately before and at 3, 24 h and 30 days after SWL. Urine NGAL concentrations were normalized to urinary Cr ruling out the confounding effect of variable hydration states. Thirty-five patients with a single renal stone were enrolled...
October 27, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27778049/geographic-location-is-an-important-determinant-of-risk-factors-for-stone-disease
#15
Ethan B Fram, Matthew D Sorensen, Vincent G Bird, Joshua M Stern
Some regions are known to have an increased burden of urolithiasis. Urolithiasis is known to be affected by weather patterns, particularly high ambient temperatures. To identify geographic differences in risk factors, we compared metabolic information for 1254 patients in two geographically distinct regions, New York and Florida, with per sample adjustment for ambient weather. We observed that patients in New York were more likely to have low urine volume, but also lower total urinary calcium (168 vs 216 mg, p = 0...
October 24, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27761633/does-a-retropulsion-prevention-device-equalize-the-surgical-success-of-ho-yag-laser-and-pneumatic-lithotripters-for-upper-ureteral-stones-a-prospective-randomized-study
#16
Sahin Bagbanci, Mumtaz Dadali, Yeliz Dadalı, Levent Emir, Ozkan Gorgulu, Ayhan Karabulut
To establish if a retropulsion prevention device for ureteral stones equalizes surgical success and push-back rates of Ho:YAG laser and pneumatic lithotripters for upper ureteral stones. Patients with upper ureteral stones (n = 267) were treated endoscopically at the Department of Urology between April 2014 and December 2015. Patients were randomly assigned to pneumatic and Ho:YAG laser lithotripters as group-1 and group-2, respectively. Lithotripsy was performed with Stone Cone(TM) in both groups. The surgical success rate on the first postoperative day was 81...
October 19, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27761632/comparative-risk-of-chronic-kidney-diseases-in-patients-with-urolithiasis-and-urological-interventions-a-longitudinal-population-based-study
#17
Shih-Yi Lin, Cheng-Li Lin, Chao-Hsiang Chang, His-Chin Wu, Wen-Chi Chen, I-Kuan Wang, Yao Lung Liu, Fung-Chang Sung, Yen-Jung Chang, Chia-Hung Kao
Large cohort studies on whether any association existed between urological interventions for urolithiasis and the development of CKD are lacking. From claims data of the National Health Insurance (NHI) program of Taiwan, we identified 54,433 patients newly diagnosed with urolithiasis during 1998-2010. For each case, four individuals without urolithiasis were randomly selected and frequency matched by age, sex, and diagnosis year. Both groups were followed up until the end of 2010. Incident CKD events were identified by the International Classification of Diseases, Ninth Revision (ICD-9) code in the NHI registration database...
October 19, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27744630/metabolic-risk-factors-in-pediatric-stone-formers-a-report-from-an-emerging-economy
#18
Kiran Imran, Mirza Naqi Zafar, Uzma Ozair, Sadia Khan, Syed Adibul Hasan Rizvi
The goal of this study was to investigate metabolic risk factors in pediatric stone formers in an emerging economy. A prospective, data collection enrolled 250 children age <1-15 years at our center. Risk factors were evaluated by gender and in age groups <1-5, 6-10 and 11-15 years. Patients were evaluated for demographics, blood and 24 h urine for calcium, magnesium, phosphate, uric acid, electrolytes and additional protein, citrate, ammonia and oxalate in urine. All reported values were two sided and statistical significance was considered at p value ≤0...
October 15, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27744629/difference-in-urinary-stone-composition-between-uyghur-and-han-children-with-urolithiasis
#19
Yang Liu, Anniwaer Yasheng, Kang Chen, Chuangxin Lan, Hamulati Tusong, Lili Ou, Yeping Liang, Hans-Göran Tiselius, Guohua Zeng, Wenqi Wu
The Objective of this study is to analyze the difference in renal stone composition between Uyghur and Han children with urolithiasis in China and possible reasons. From May 2011 to September 2013, we analyzed the stone compositions of 274 Chinese children with urolithiasis, including 151 Uyghur children from Xinjiang Province and 123 Han children from Guangdong Province. All the stone components were determined by Infrared spectroscopy and the main components were recorded. We also evaluated the data, including age, gender and geographic region of the patients...
October 15, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27717996/a-comparison-of-efficacy-of-doxazosin-4-and-8%C3%A2-mg-in-medical-expulsive-therapy-of-distal-ureteral-stones-a-prospective-randomized-clinical-trial
#20
Haluk Sen, Sakip Erturhan, Erkan Sadioglu, Omer Bayrak, İlker Seckiner
We aimed to investigate the efficacy of two different doses of doxazosin, 4 and 8 mg, in medical expulsive therapy (MET). This prospective randomized study included a total of 66 patients with distal ureteral stones which were radio-opaque and ≤10 mm. All patients were randomly divided into three groups: Group 1 included 25 patients receiving 4 mg doxazosin. Group 2 included 22 patients receiving 8 mg doxazosin. Diclofenac 100 mg p.o. and daily 1500-2000 cc hydration were advised to the patients in Groups 1 and 2 to relieve pain...
October 7, 2016: Urolithiasis
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