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Urolithiasis

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https://www.readbyqxmd.com/read/28884349/functional-and-morphological-recovery-of-solitary-kidneys-after-drainage-double-j-stent-placement-vs-emergency-ureteroscopy-which-one-is-reasonable
#1
Kemal Sarica, Fatih Tarhan, Kutluhan Erdem, Ahmet Halil Sevinc, Rasim Guzel, Bilal Eryildirim
The purpose of the study was to evaluate the functional and morphological recovery of solitary kidneys following the relief of obstruction by two different approaches. Data of 65 adult patients with acute renal failure in obstructed solitary kidney were evaluated. Depending on the type of emergent decompression procedure while 34 patients were treated with a double J stent placement only 31 patients underwent ureteroscopic lithotripsy with double J stent placement. Following these procedures, in addition to the amount of excreted urine during the first 24 h, changes in the serum creatinine levels and the degree of hydronephrosis were noted and evaluated during the first week of follow-up after intervention...
September 7, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28776078/sarna-mediated-activation-of-trpv5-reduces-renal-calcium-oxalate-deposition-in-rat-via-decreasing-urinary-calcium-excretion
#2
Tao Zeng, Xiaolu Duan, Wei Zhu, Yang Liu, Wenqi Wu, Guohua Zeng
Hypercalciuria is a main risk factor for kidney stone  formation. TRPV5 is the gatekeeper protein for mediating calcium transport and reabsorption in the kidney. In the present study, we tested the effect of TRPV5 activation with small activating RNA (saRNA), which could induce gene expression by targeting the promoter of the gene, on ethylene glycol (EG)-induced calcium oxalate (CaOx) crystals formation in rat kidney. Five pairs of RNA activation sequences targeting the promoter of rat TRPV5 were designed and synthesized...
August 3, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28756459/comparison-of-stone-croes-and-guy-s-nephrolithometry-scoring-systems-for-predicting-stone-free-status-and-complication-rates-after-percutaneous-nephrolithotomy-in-obese-patients
#3
Faruk Ozgor, Fatih Yanaral, Metin Savun, Harun Ozdemir, Omer Sarilar, Murat Binbay
In this study, we aim to evaluate the accuracy of STONE (stone size, tract length, obstruction, number of involved calyces, and essence/stone density), Clinical Research Office of the Endourological Society (CROES), and Guy's nephrolithometry scoring systems (NSS) in obese patients. The charts of patients who underwent percutaneous nephrolithotomy (PNL) between June 2008 and June 2016 were retrospectively analyzed. Calculations of the STONE, CROES, and Guy's NSS were performed by a resident who was well informed regarding each NSS...
July 29, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28756458/comparison-of-intermediate-and-low-frequency-shock-wave-lithotripsy-for-pediatric-kidney-stones
#4
Onur Kaygısız, Hakan Kılıçarslan, Ahmet Mert, Burhan Coşkun, Yakup Kordan
The aim of the study to compare low and intermediate shock wave frequency rates in terms of success and complications for treating pediatric kidney stones. This retrospective study was performed on 58 consecutive pediatric patients (24 girls, 34 boys) who underwent shock wave lithotripsy (SWL) for kidney stones with an electrohydraulic lithotripter between April 2014 and March 2016. In the first year, all children underwent SWL with a frequency of 90 SWs/min as an intermediate frequency (Group 90), and in the second year all children were treated by SWL using 60 SWs/min as a low frequency (Group 60)...
July 29, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28718073/a-randomised-phase-ii-iii-study-to-evaluate-the-efficacy-and-safety-of-orally-administered-oxalobacter-formigenes-to-treat-primary-hyperoxaluria
#5
Dawn Milliner, Bernd Hoppe, Jaap Groothoff
Primary hyperoxaluria (PH) patients overproduce oxalate because of rare genetic errors in glyoxylate metabolism. Recurrent urolithiasis and/or progressive nephrocalcinosis are PH hallmarks and can lead to kidney damage, systemic oxalosis and death. Based on previous studies, we hypothesised that treatment with the oxalate-metabolizing bacterium Oxalobacter formigenes would mediate active elimination of oxalate from the plasma to the intestine of PH patients, thereby reducing urinary oxalate excretion (Uox)...
July 17, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28702679/predictive-factors-of-bleeding-among-pediatric-patients-undergoing-percutaneous-nephrolithotomy
#6
Cagri Senocak, Ridvan Ozbek, Omer Faruk Bozkurt, Ali Unsal
The purpose of this study is to determine the perioperative risk factors for increased blood loss in children undergoing percutaneous nephrolithotomy (PCNL).We retrospectively reviewed the data on pediatric patients who had undergone PCNL for stone disease in our department. Blood loss estimation was quantified by measuring the changes in hematocrit plus the volume of red blood cells transfused. Univariate and multivariate linear regression analyses were performed to evaluate risk factors associated with increased blood loss after pediatric PCNL...
July 12, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28695238/predictive-risk-factors-for-systemic-inflammatory-response-syndrome-following-ureteroscopic-laser-lithotripsy
#7
Yusuke Uchida, Ryoji Takazawa, Sachi Kitayama, Toshihiko Tsujii
The objective of this study was to investigate risk factors for the development of systemic inflammatory response syndrome following ureteroscopic laser lithotripsy. We retrospectively collected data of 469 patients who underwent ureteroscopic laser lithotripsy at our single institution from February 2008 to June 2016. Details for the patient, the stone, and the surgical factors that potentially contributed to postoperative infection were extracted. Using a logistic regression model, we analyzed how the clinical factors affected the incidence of systemic inflammatory response syndrome...
July 10, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28681267/intravenous-paracetamol-vs-ibuprofen-in-renal-colic-a-randomised-double-blind-controlled-clinical-trial
#8
E Cenker, M Serinken, E Uyanık
Pain management is one of the essentials of emergency care. Renal colic secondary to urinary stone disease forms one of the most intense pain types. The present study aimed to compare the effect of intravenous ibuprofen to paracetamol in ceasing renal colic. This randomised double-blind study was composed of two intervention arms, intravenous paracetamol and intravenous ibuprofen. Study subjects were randomised to receive a single dose of either paracetamol, 1 g in 100 ml normal saline, or ibuprofen (800 mg in 100 ml normal saline) in a blinded fashion...
July 5, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28674784/vitamin-b6-intake-and-the-risk-of-incident-kidney-stones
#9
Pietro Manuel Ferraro, Eric N Taylor, Giovanni Gambaro, Gary C Curhan
Higher vitamin B6 intake might reduce urinary excretion of oxalate, one of the major determinants of risk for calcium oxalate kidney stones. Previous studies investigating the association between intake of vitamin B6 and risk of stones found conflicting results. We sought to investigate the association in three large prospective cohorts. We prospectively examined the association in the Health Professionals Follow-up Study (HPFS; n = 42,919 men), Nurses' Health Study I (NHS I; n = 60,003 older women), and Nurses' Health Study II (NHS II; n = 90,629 younger women)...
July 3, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28660284/primary-hyperoxaluria-in-populations-of-pakistan-origin-results-from-a-literature-review-and-two-major-registries
#10
REVIEW
Jamsheer Jehangir Talati, Sally-Anne Hulton, Sander F Garrelfs, Wajahat Aziz, Shoaib Rao, Amanullah Memon, Zafar Nazir, Raziuddin Biyabani, Saqib Qazi, Iqbal Azam, Aysha Habib Khan, Jamil Ahmed, Lena Jafri, Mohammad Zeeshan
Primary hyperoxalurias (PH) are devastating, autosomal recessive diseases causing renal stones. Undifferentiated hyperoxaluria is seen in up to 43% of Pakistani paediatric stone patients. High rates of consanguinity in Pakistan suggest significant local prevalence. There is no detailed information regarding number of cases, clinical features, and genetics in Pakistan-origin (P-o) patients. We reviewed available information on P-o PH patients recorded in the literature as well as from two major PH registries (the Rare Kidney Stone Consortium PH Registry (RKSCPHR) and the OxalEurope PH Registry (OxER); and the Aga Khan University Hospital in Pakistan...
June 28, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28660283/a-new-method-for-predicting-uric-acid-composition-in-urinary-stones-using-routine-single-energy-ct
#11
Mats Lidén
Urinary stones composed of uric acid can be treated medically. Prediction of uric acid stone type is, therefore, desirable when a urinary stone is diagnosed with unenhanced CT. The purpose of the present study was to describe single-energy thin slice quantitative CT parameters of urinary stones correlated to chemical stone type and to develop a method to distinguish pure uric acid stones (UA) from other stones (non-UA/Mix). Unenhanced thin slice single-energy CT images of 126 urinary stones (117 patients) with known chemical stone type were retrospectively included in the study...
June 28, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28361470/pathogenesis-of-calcium-oxalate-urinary-stone-disease-species-comparison-of-humans-dogs-and-cats
#12
REVIEW
Allison L O'Kell, David C Grant, Saeed R Khan
Idiopathic calcium oxalate nephrolithiasis is a highly recurrent disease that is increasing in prevalence. Decades of research have not identified effective methods to consistently prevent the formation of nephroliths or induce medical dissolution. Idiopathic calcium oxalate nephroliths form in association with renal papillary subepithelial calcium phosphate deposits called Randall's plaques (RPs). Rodent models are commonly used to experimentally induce calcium oxalate crystal and stone formation, but a rodent model that conclusively forms RPs has not been identified...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/28314883/stone-former-urine-proteome-demonstrates-a-cationic-shift-in-protein-distribution-compared-to-normal
#13
Ann M Kolbach-Mandel, Neil S Mandel, Brian R Hoffmann, Jack G Kleinman, Jeffrey A Wesson
Many urine proteins are found in calcium oxalate stones, yet decades of research have failed to define the role of urine proteins in stone formation. This urine proteomic study compares the relative amounts of abundant urine proteins between idiopathic calcium oxalate stone forming and non-stone forming (normal) cohorts to identify differences that might correlate with disease. Random mid-morning urine samples were collected following informed consent from 25 stone formers and 14 normal individuals. Proteins were isolated from urine using ultrafiltration...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/27822582/are-there-any-predictors-of-pyonephrosis-in-patients-with-renal-calculus-disease
#14
Madhusudan Patodia, Apul Goel, Vishwajeet Singh, Bhupendra Pal Singh, Rahul Janak Sinha, Manoj Kumar, Divakar Dalela, Satya Narayan Sankhwar
The objective of the study is to identify factors predicting development of pyonephrosis in patients of renal calculus disease (RCD), as this knowledge is largely unknown. Patients of RCD without pyonephrosis (Group 1) or with pyonephrosis (Group 2) presenting between December 2013 and November 2015 were evaluated. All patients of RCD who had undergone either percutaneous nephrostomy (PCN) or surgical management (percutaneous nephrolithotomy/pyelolithotomy/nephrectomy) were included. Patients treated conservatively, by extracorporeal shock-wave lithotripsy and patients of bilateral RCD were excluded...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/27787615/neutrophil-gelatinase-associated-lipocalin-ngal-value-changes-before-and-after-shock-wave-lithotripsy
#15
Matteo Vittori, Silvia Baroni, Pietro Manuel Ferraro, Giovanni Gambaro, Renato Morelli, PierFrancesco Bassi, Alessandro D'Addessi
Our aim was to determine short and medium-term changes of neutrophil gelatinase-associated lipocalin (NGAL) in the urine of patients undergoing shock wave lithotripsy (SWL). In patients with kidney stones, serum urea and creatinine (Cr), urine Cr and NGAL levels were determined immediately before and at 3, 24 h and 30 days after SWL. Urine NGAL concentrations were normalized to urinary Cr ruling out the confounding effect of variable hydration states. Thirty-five patients with a single renal stone were enrolled...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/27744630/metabolic-risk-factors-in-pediatric-stone-formers-a-report-from-an-emerging-economy
#16
Kiran Imran, Mirza Naqi Zafar, Uzma Ozair, Sadia Khan, Syed Adibul Hasan Rizvi
The goal of this study was to investigate metabolic risk factors in pediatric stone formers in an emerging economy. A prospective, data collection enrolled 250 children age <1-15 years at our center. Risk factors were evaluated by gender and in age groups <1-5, 6-10 and 11-15 years. Patients were evaluated for demographics, blood and 24 h urine for calcium, magnesium, phosphate, uric acid, electrolytes and additional protein, citrate, ammonia and oxalate in urine. All reported values were two sided and statistical significance was considered at p value ≤0...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/27709258/the-utility-of-diffusion-weighted-imaging-to-assess-acute-renal-parenchymal-changes-due-to-unilateral-ureteral-stone-obstruction
#17
Kürşat Düzenli, Mehmet Öztürk, İsmail Okan Yıldırım, Gülnur Erdem
Our aim in this study was to evaluate the use of diffusion-weighted imaging (DWI) for acute renal parenchymal changes occurring as a result of unilateral ureteral obstruction due to stones. Twenty four patients with obstructed and opposite unobstructed kidney were enrolled in this prospective study. DWI was used at two different b values (b = 0 s/mm(2) and b = 1000 s/mm(2)). Apparent diffusion coefficient (ADC) measurements were completed on the upper pole, central section and lower pole parenchyma of both kidneys...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/27704184/mini-percutaneous-nephrolithotomy-for-stones-in-anomalous-kidneys-a-prospective-study
#18
Sanjay Khadgi, Babu Shrestha, Hamdy Ibrahim, Sunil Shrestha, Mohammed S ElSheemy, Ahmed M Al-Kandari
To evaluate safety and efficacy of minipercutaneous nephrolithotomy (Mini-PNL) in management of stones in different types of renal anomalies. Patients with stones ≥2 cm or SWL-resistant stones in anomalous-kidneys treated by Mini-PNL between March 2010 and September 2012 were included prospectively. Mini-PNL was done under regional anesthesia in prone position with fluoroscopic guidance through 18 Fr sheath using semirigid ureteroscope (8.5/11.5 Fr) and pneumatic lithotripter. All patients were followed-up for 2-3 years...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/27677484/transient-cessation-of-antiplatelet-medication-before-percutaneous-stone-surgery-does-it-have-any-safety-concern-on-bleeding-related-problems
#19
Cahit Sahin, Utku Can, Bilal Eryildirim, Kemal Sarica
To evaluate the short term effects of transient AP medication cessation on the safety of percutaneous nephrolithotomy (PCNL) and evaluate them with normal cases in a comparative manner. 71 cases undergoing PCNL for renal pelvic stones were divided into two groups: Group 1 (n: 35) Cases under AP medication (100 mg/day acetyl salicylic acid) in whom the medication was stopped for 7 days before PCNL procedure. Group 2 (n: 36) Cases without any AP medication prior to PCNL. Coagulation test parameters were normal in all cases prior to stone removal...
August 2017: Urolithiasis
https://www.readbyqxmd.com/read/27638520/the-surgical-experience-influences-the-safety-of-retrograde-intrarenal-surgery-for-kidney-stones-a-propensity-score-analysis
#20
F Berardinelli, L Cindolo, P De Francesco, S Proietti, D Hennessey, O Dalpiaz, C M Cracco, F Pellegrini, C M Scoffone, L Schips, G Giusti
The aim of this study is to evaluate if surgical experience could influence the outcomes of retrograde intrarenal surgery (RIRS) in terms of stone clearance and complication rate. Patients from five institutions were included in this study. Patients were divided into two groups. Group 1: patients treated by three surgeons in the early phase of learning curve (surgical experience <100 procedures); Group 2: cases operated by two surgeons with great endourological experience (>400 procedures). Patients and stone characteristics, outcome and complications were analyzed...
August 2017: Urolithiasis
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