journal
https://read.qxmd.com/read/38016656/dermaceutical-utilization-of-nigella-sativa-seeds-applications-and-opportunities
#21
JOURNAL ARTICLE
Mariyam Khatoon, Poonam Kushwaha, Shazia Usmani, Kumud Madan
Skin diseases have recently become a major concern among people of all ages due to their highly visible symptoms and persistent and difficult treatment, which significantly impact their quality of life. Nigella sativa seeds, also known as "black seeds" or "kalonji," are one of the most commonly used herbal medicines due to their wide range of biological and pharmacological activities. It contains a wide range of bioactive constituents found in both fixed and essential oils. It has been used for hundreds of years as an alternative ethnomedicine to treat a wide range of skin conditions...
November 28, 2023: Drug Research
https://read.qxmd.com/read/38016655/parenteral-fosfomycin-in-gastrointestinal-surgery-a-systematic-review
#22
JOURNAL ARTICLE
Siv Fonnes, Masja Klindt Fonnes, Barbara Juliane Holzknecht, Jacob Rosenberg
BACKGROUND: To investigate if perioperative parenteral administration of fosfomycin given before or during gastrointestinal surgery could protect against postoperative infectious complications and characterise the administration of fosfomycin and its harms. METHODS: This systematic review included original studies on gastrointestinal surgery where parental administration of fosfomycin was given before or during surgery to≥5 patients. We searched three databases on March 24 2023 and registered the protocol before data extraction (CRD42020201268)...
November 28, 2023: Drug Research
https://read.qxmd.com/read/37935204/effects-of-resveratrol-co-administration-on-celecoxib-disposition-and-pharmacokinetics-in-healthy-volunteers
#23
JOURNAL ARTICLE
Nagwa I Helal, Noha M El-Khodary, Gamal A Omran, Soha M El-Masry
The objective of the current study was to investigate the effects of resveratrol (RSV), a natural herbal remedy used as an adjacent anti-inflammatory supplement on, the pharmacokinetics of celecoxib in healthy male volunteers. Twelve healthy human participants were involved in two-period open-labeled trial. Celecoxib (200 mg) was given as a single oral dose under fasting conditions as a control phase. Afterward, RSV (500 mg) commenced as a single oral dose for ten days as a treatment phase. Blood samples were collected during the control and treatment phases and analyzed using the validated High-performance liquid chromatography (HPLC) method...
November 2023: Drug Research
https://read.qxmd.com/read/37935203/diuretic-natriuretic-and-ca2-sparing-effect-of-the-alkaloid-boldine-in-rats
#24
JOURNAL ARTICLE
Viviane Miranda Bispo Steimbach, Ritade Cássia Vilhena da Silva, Luísa Nathália Bolda Mariano, Mariana Zanovello, Anelise Felício Macarini, Luisa Mota da Silva, Priscila de Souza
BACKGROUND: Previous studies indicate the renal vasodilating effects of boldine, an alkaloid found in Peumus boldus . However, its potential to induce diuresis still needs to be studied. METHODS: Wistar rats were used and the urine volume was noted for 8 h and further studied. RESULTS: The acute treatment at 0.1 and 0.3 mg/kg of boldine showed a diuretic, natriuretic, and Ca2+ -sparing effect in rats without changing the urinary elimination of K+ and Cl- ...
November 2023: Drug Research
https://read.qxmd.com/read/37935202/inotodiol-ameliorates-the-progression-of-osteoarthritis-an-in-vitro-and-in-vivo-study
#25
JOURNAL ARTICLE
Wanfeng Qian, Ruheng Ji, Qiujie Ye, Wenjun Hu, Linying Zhou, Hongwu Pan, Xiaoming Li
Osteoarthritis is a common chronic degenerative disease, of which the essence is the degenerative changes of bone and joint cartilage, involving damage in multiple structures such as bone, synovium and joints. In the mechanism of arthritis inflammation is closely related, and therefore the exploration to inhibit inflammatory mediators is crucial for the clinical prevention and treatment of osteoarthritis. Inotodiol is a lanostane triterpenoid isolated from Inonotus obliquus, which had been extensively reported to be an anti-inflammatory agent, but its effect on arthritis remains unknown...
November 2023: Drug Research
https://read.qxmd.com/read/37890514/a-review-of-parp-1-inhibitors-assessing-emerging-prospects-and-tailoring-therapeutic-strategies
#26
JOURNAL ARTICLE
Soundarya Ramesh, Shannon D Almeida, Sameerana Hammigi, Govardan Katta Radhakrishna, Golla Sireesha, Theivendren Panneerselvam, Shangavi Vellingiri, Selvaraj Kunjiappan, Damodar Nayak Ammunje, Parasuraman Pavadai
Eukaryotic organisms contain an enzyme family called poly (ADP-ribose) polymerases (PARPs), which is responsible for the poly (ADP-ribosylation) of DNA-binding proteins. PARPs are members of the cell signaling enzyme class. PARP-1, the most common isoform of the PARP family, is responsible for more than 90% of the tasks carried out by the PARP family as a whole. A superfamily consisting of 18 PARPs has been found. In order to synthesize polymers of ADP-ribose (PAR) and nicotinamide, the DNA damage nick monitor PARP-1 requires NAD+ as a substrate...
October 27, 2023: Drug Research
https://read.qxmd.com/read/37647930/evaluation-and-comparison-of-citalopram-and-venlafaxine-for-management-of-hot-flashes-in-women-with-breast-cancer
#27
RANDOMIZED CONTROLLED TRIAL
Sasan Yaghoobi Taleghani, Farnaz Etesam, Mohsen Esfandbod
BACKGROUND: Breast cancer is the most common cancer in women worldwide. Premature menopause and hot flashes are the main complications of breast cancer treatments. About 40 to 50 percent of breast cancer women who undergo chemotherapy are experiencing premature menopause symptoms, including hot flashes. Some endocrine therapies such as tamoxifen and aromatase inhibitors are associated with induction or aggravating hot flashes. Hot flashes are often debilitating and significantly impair daily functions...
October 2023: Drug Research
https://read.qxmd.com/read/37625445/lupeol-a-triterpenoid-isolated-from-the-stem-bark-of-hymenocardia-acida-tul-exhibits-a-van-der-waal-antagonism-on-the-alpha-subunit-of-gastric-h-k-atpase-a-promising-antiulcer-principle
#28
JOURNAL ARTICLE
Adedokun Oluwasegun, Ume Ogochukwu, Ojukwu Ugochukwu, Ismail Mussaddiq, Ayinde Bunyamin
BACKGROUND: Hymenocardia acida (HA) is one of the numerous medicinal plants in Nigeria with ethnomedicinal history of usage in the treatment of ulcer. The study aimed at isolating antiulcer principle(s) from the stem bark of HA as well as the mechanism of action determination. METHODS: Antiulcer screenings of the crude extract, aqueous fraction, and bulked VLC fractions were performed using in vivo and in vitro models. Docking was carried out by using PyRx. RESULTS: Crude extract (HA; 1 mg/mL) and the aqueous fraction of H...
August 25, 2023: Drug Research
https://read.qxmd.com/read/37591260/altered-gene-expression-of-cytochrome-p450-and-abc-transporter-in-human-hepatocellular-carcinoma-hepg2-cells-exposed-to-bardoxolone-methyl
#29
JOURNAL ARTICLE
Katsuhito Nagai, Shuhei Fukuno, Takeshi Miura, Eri Yasuda-Imanishi, Hiroki Konishi
Bardoxolone methyl (BX) is expected to be an innovate therapeutic agent for chronic kidney disease (CKD). The aim of the present study was to examine whether the expression of subtypes of cytochrome P450 (CYP) and ABC transporters was altered in human hepatocellular carcinoma HepG2 cells by exposure to BX. The expression of mRNAs for CYP1A2, CYP2E1, P-glycoprotein, multidrug resistance-associated protein 1-3, and breast cancer resistance protein was significantly increased by exposure of HepG2 cells to BX, while the expression of CYP3A4 mRNA was significantly decreased under the same conditions...
August 17, 2023: Drug Research
https://read.qxmd.com/read/37591259/gc-ms-analysis-and-in-silico-docking-of-constituents-of-cinnamomum-malabatrum-against-cyp450-17%C3%AE-and-cyp450-19-aromatase-key-targets-for-hyperandrogenism
#30
JOURNAL ARTICLE
V Soumya, S Deepa, Knolin K Thachil, J Saravanan, R Hariprasad
Poly cystic ovary syndrome (PCOS) is considered as one of the common hormonal disorders affecting 6-20% of women in their reproductive age with characteristic features include anovulatory infertility, hyperandrogenism, cystic follicles and insulin resistance. The gene CYP play an important role in pathophysiology of hyperandrogenism associated with PCOS. An elevated androgens are reported in PCOS condition due to overexpression of the enzyme CYP450 17 α: . As well as diminished levels of aromatase (CYP450 19) were observed in several hyperandrogenic PCOS patients...
August 17, 2023: Drug Research
https://read.qxmd.com/read/37487523/nitrosamine-impurities-in-herbal-formulations-a-review-of-risks-and-mitigation-strategies
#31
JOURNAL ARTICLE
Nunavath Raja Shekhar, Krishnaveni Nagappan, Madhu Tanya Singh, S P Dhanabal
Nitrosamines are a class of chemical compounds that have been found to be impurities in a variety of pharmaceutical products. These impurities have raised concerns due to their potential carcinogenic effects. Recent studies have identified nitrosamines as impurities in a number of pharmaceutical products including angiotensin II receptor blockers (ARBs) and proton pump inhibitors (PPIs). The presence of nitrosamines in these products has led to recalls and market withdrawals. In addition to pharmaceuticals, nitrosamines have also been found in some herbal medicines particularly those containing traditional Chinese medicinal ingredients...
July 24, 2023: Drug Research
https://read.qxmd.com/read/37487522/in-silico-docking-and-molecular-dynamic-md-simulations-studies-of-selected-phytochemicals-against-human-glycolate-oxidase-hgox-and-oxalate-oxidase-oxo
#32
JOURNAL ARTICLE
Patnam Nageswari, K Swathi
Globally, Urolithiasis is the most prevalent urological problem which affects the populations across the ages and races. In recent years, several phytochemicals are being investigated to improve the efficacy and safety of anti-urolithiasis formulations. To develop drugs based on traditional medicines, it is essential to understand the molecular mechanism of action of these drugs. We present the results of in silico docking and molecular dynamic (MD) simulation studies on selected phytochemical including catechin, epicatechin, gallic acid, gallocatechin, epigallocatechin, epigallocatechin 3-o-gallate, 4-methoxy-nor-securine, nor-securinine, and fisetin with human glycolate oxidase (hGOX) and oxalate oxidase (OxO)...
July 24, 2023: Drug Research
https://read.qxmd.com/read/37478892/repurposing-drugs-an-empowering-approach-to-drug-discovery-and-development
#33
JOURNAL ARTICLE
Sahil Kumar, Vandana Roy
Drug discovery and development is a time-consuming and costly procedure that necessitates a substantial effort. Drug repurposing has been suggested as a method for developing medicines that takes less time than developing brand new medications and will be less expensive. Also known as drug repositioning or re-profiling, this strategy has been in use from the time of serendipitous drug discoveries to the modern computer aided drug designing and use of computational chemistry. In the light of the COVID-19 pandemic too, drug repurposing emerged as a ray of hope in the dearth of available medicines...
July 21, 2023: Drug Research
https://read.qxmd.com/read/37311557/correction-circulating-fatty-acid-binding-protein-4-response-to-acute-aerobic-exercise-in-healthy-menartificial-intelligence-for-computer-aided-drug-discovery
#34
JOURNAL ARTICLE
Aditya Kate, Ekkita Seth, Ananya Singh, Chandrashekhar Mahadeo Chakole, Meenakshi Kanwar Chauhan, Ravi Kant Singh, Shrirang Maddalwar, Mohit Mishra
No abstract text is available yet for this article.
June 13, 2023: Drug Research
https://read.qxmd.com/read/37308093/age-rage-pathways-cardiovascular-disease-and-oxidative-stress
#35
JOURNAL ARTICLE
Neeraj Sharma, Pavan Kumar, Karuna Shanker Shukla, Shubhrat Maheshwari
It is well established that Advanced Glycation End Products (AGEs) and their receptor (RAGE) are primarily responsible for the development of cardiovascular disease. As a result, diabetic therapy is very interested in therapeutic strategies that can target the AGE-RAGE axis. The majority of the AGE-RAGE inhibitors showed encouraging outcomes in animal experiments, but more information is needed to completely understand their clinical effects. The main mechanism implicated in the aetiology of cardiovascular disease in people with diabetes is oxidative stress and inflammation mediated by AGE-RAGE interaction...
June 12, 2023: Drug Research
https://read.qxmd.com/read/37308092/phytopharmaceuticals-and-herbal-approaches-to-target-neurodegenerative-disorders
#36
JOURNAL ARTICLE
Anas Islam, Anuradha Mishra, Rabia Ahsan, Syed Fareha
Neurodegeneration is characterized as the continuous functional and structural loss of neurons, resulting in various clinical and pathological manifestations and loss of functional anatomy. Medicinal plants have been oppressed from ancient years and are highly considered throughout the world as a rich source of therapeutic means for the prevention, treatment of various ailments. Plant-derived medicinal products are becoming popular in India and other nations. Further herbal therapies shows good impact on chronic long term illnesses including degenerative conditions of neurons and brain...
June 12, 2023: Drug Research
https://read.qxmd.com/read/37276884/artificial-intelligence-for-computer-aided-drug-discovery
#37
JOURNAL ARTICLE
Aditya Kate, Ekkita Seth, Ananya Singh, Chandrashekhar Mahadeo Chakole, Meenakshi Kanwar Chauhan, Ravi Kant Singh, Shrirang Maddalwar, Mohit Mishra
The continuous implementation of Artificial Intelligence (AI) in multiple scientific domains and the rapid advancement in computer software and hardware, along with other parameters, have rapidly fuelled this development. The technology can contribute effectively in solving many challenges and constraints in the traditional development of the drug. Traditionally, large-scale chemical libraries are screened to find one promising medicine. In recent years, more reasonable structure-based drug design approaches have avoided the first screening phases while still requiring chemists to design, synthesize, and test a wide range of compounds to produce possible novel medications...
June 5, 2023: Drug Research
https://read.qxmd.com/read/37236230/effects-of-sglt2-inhibitors-on-the-intestinal-bacterial-flora-in-japanese-patients-with-type-2-diabetes-mellitus
#38
JOURNAL ARTICLE
Masataka Kusunoki, Fumiya Hisano, Shin-Ichi Matsuda, Akiko Kusunoki, Naomi Wakazono, Kazuhiko Tsutsumi, Tetsuro Miyata
Selective inhibitors of sodium glucose co-transporter-2 (SGLT2) suppress renal glucose reabsorption and promote urinary glucose excretion, thereby lowering blood glucose. SGLT2 inhibitors have been reported to reduce body weight. However, the mechanism underlying the reduction in the body weight induced by SGLT2 inhibitor treatment remains to be elucidated. In this study, we investigated the effects of SGLT2 inhibitors on the intestinal bacterial flora. A total of 36 Japanese patients with type 2 diabetes mellitus received a SGLT2 inhibitor (luseogliflozin or dapagliflozin) for 3 months, and the prevalences of balance-regulating bacteria and balance-disturbing bacteria in the feces of the patients before and after SGLT2 inhibitor treatment were determined...
May 26, 2023: Drug Research
https://read.qxmd.com/read/37230480/arsenic-trioxide-induced-cytotoxicity-in-a549-cells-the-role-of-necroptosis
#39
JOURNAL ARTICLE
Maryam Jamil, Afshin Mohammadi-Bardbori, Omid Safa, Amin Reza Nikpoor, Azizollah Bakhtari, Mahnoosh Mokhtarinejad, Saghar Naybandi Zadeh, Amir Shadboorestan, Mahmoud Omidi
INTRODUCTION: Lung cancer is one of the deadliest cancers globally. Arsenic trioxide (ATO) is still present as a highly effective drug in treating acute promyelocytic leukemia (APL). Chemotherapy resistance is one of the major problems in cancer therapy. Necroptosis, can overcomes resistance to apoptosis, and can promote cancer treatment. This study examines the necroptosis pathway in A549 cancer cells exposed to ATO. METHODS: We used the MTT test to determine the ATO effects on the viability of A549 cells at three different time intervals...
May 25, 2023: Drug Research
https://read.qxmd.com/read/37220791/efficacy-and-safety-of-valproic-acid-in-myelodysplastic-syndrome-and-acute-myeloid-leukemia-a-narrative-review
#40
JOURNAL ARTICLE
Navid Omidkhoda, Sina Mahdiani, Sara Samadi, Hossein Rahimi, Amir Hooshang Mohammadpour
Loads of new therapeutic regimes have been turned up to manage Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly in elderly patients who are unfit for intensive chemotherapy. Despite accumulating research, the best MDS and AML management approach is indeterminate. Myelodysplastic syndrome implies a group of various hematopoietic stem cell disorders that may progress to acute myeloid leukemia. These disorders are more frequent in older adults. To the high rate of morbidity and abundant toxicities related to the therapeutic approaches, also, the treatment would be challenging...
May 23, 2023: Drug Research
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