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Drug Research

Abbas Mohammadpour, Mahmood Dehghani Ashkezari, Behrokh Farahmand, Mohammad Shokrzadeh
BACKGROUND: Tramadol overdose is disproportionately more common in Iran, and in recent years, it has become one of the most common causes of poisoning admissions to emergency departments in this country. Tramadol is a synthetic analogue of codeine and a weak opioid receptor (μ) agonist that can cause seizures even in commonly used doses. AIMS: This study aimed to examine the relationship between seizure and plasma tramadol concentration in patients with tramadol poisoning who referred to one of the hospitals in Ghaemshahr, Iran...
July 11, 2018: Drug Research
Sarvin Mohammadi-Aghdam, Bahareh Valinezhad-Saghezi, Yousef Mortazavi, Seyedeh Masoumeh Qhoreishi
The adsorption capacity and release attributes of magnetic Fe3 O4 @hydroxyapatite (Fe3 O4 /HAp) nanoparticles for drug molecules can be improved by modified their surfaces with logical chosen organic groups. The internal surface of nanoparticles was functionalized with (3-aminopropyl) trimethoxysilane (APTS). Comparative studies of their adsorption and release properties for various model drug molecules (such as pure hydroxyapatite, Fe3 O4 @hydroxyapatite and functionalized Fe3 O4 @hydroxyapatite) were then conducted...
July 11, 2018: Drug Research
Ravi Kumar Jairam, Sadanand Rangnathrao Mallurwar, Suresh P Sulochana, Devaraj V Chandrasekar, Ravi Kanth Bhamidipati, Wolfgang Richter, Nuggehally R Srinivas, Ramesh Mullangi
Bendamustine, an alkylating anticancer agent, is used to treat chronic lymphocytic leukemia by intravenous infusion alone or in combination. The work aimed to develop a method to predict time vs. concentration profile for humans based on preclinical pharmacokinetics using the assumption of superimposability of normalized time course profiles of animals and humans. Standard allometric equations with/without correction factors (CF) were also used in prediction. The Vss was predicted by simple allometry of 0.312W0...
July 11, 2018: Drug Research
Isaac A Adedara, Sanmi E Alake, Laide O Olajide, Mercy O Adeyemo, Temitayo O Ajibade, Ebenezer O Farombi
There is a growing global interest in hypertension due to its associated complications including renal dysfunction in patients. The thyroid system reportedly regulates renal function in both animal and human. The present study investigated the therapeutic efficacy of taurine on renal and thyroid dysfunctions in hypertensive rats. Hypertension was induced by oral administration of nitric oxide synthase inhibitor, N-nitro L-arginine-methyl-ester (L-NAME), at 40 mg/kg body weight to the male Wistar rats for 14 consecutive days...
July 11, 2018: Drug Research
Ana P L Perdigão, Natalícia de Jesus Antunes, Lucas T Juni, Noedi L de Freitas, Julio Rojas-Moscoso, Sílvia V M Corrêa, Ronaldo C da Costa, Ronilson A Moreno, Gustavo D Mendes, Gilberto De Nucci
BACKGROUND: Riluzole is a benzothiazole anticonvulsant used in the treatment of patients with amyotrophic lateral sclerosis and it is being investigated for clinical use in patients with spinal cord injury. The present study evaluated the pharmacokinetics of riluzole in beagle dogs after oral dose administration. METHODS: The oral doses (1.5, 5, 15 and 50 mg/kg) of riluzole were administered to beagle dogs and blood samples were collected from 0 h to 24 h post drug administration...
July 10, 2018: Drug Research
Wanqing Li, Hongyuan Ba, Peng Huang, Aiping Zheng, Xi Yang
OBJECTIVE: To study the preparation technique of 5-fluorouracil and the release characteristic of 5-fluorouracil-loaded chitosan microspheres for the intranasal administration. METHODS: 5-fluorouracil-loaded chitosan microspheres were prepared by emulsion chemical cross-link technique. The orthogonal experimental design was used to optimize the preparation procedure. Dynamic dialysis method was applied to determine the release characteristic of microspheres in vitro and its influencing factors...
July 2, 2018: Drug Research
Masataka Kusunoki, Yukie Natsume, Tetsuro Miyata, Kazuhiko Tsutsumi, Yoshiharu Oshida
In patients with type 2 diabetes mellitus who show suboptimal blood glucose control under insulin therapy alone, concomitant treatment with an additional hypoglycemic agent that differs in its mechanism of action from insulin may be considered. We conducted this clinical trial to explore whether further control of increased blood glucose level can be achieved with concomitant use of sodium glucose co-transporter 2 (SGLT2) inhibitor as concomitant with other hypoglycemic therapy, as compared to SGLT2 inhibitor monotherapy, in patients with type 2 diabetes mellitus showing decrease in blood glucose level but less than the effect of insulin monotherapy and there was no significant differences...
July 2, 2018: Drug Research
Masataka Kusunoki, Yukie Natsume, Tetsuro Miyata, Kazuhiko Tsutsumi, Yoshiharu Oshida
We conducted this study to determine whether additional administration of a dipeptidyl peptidase-4 (DPP-4) inhibitor might provide further improvement of the glycemic control in Japanese type 2 diabetes patients showing relatively good glycemic control under treatment with a sodium glucose co-transporter 2 (SGLT2) inhibitor. Five SGLT2 inhibitor (luseogliflozin, dapagliflozin, tofogliflozin, empagliflozin and canagliflozin) preparations and five DPP-4 inhibitor (sitagliptin, vildagliptin, alogliptin, anagliptin and linagliptin) preparations were used...
July 2, 2018: Drug Research
Mario Alberto Isiordia-Espinoza, Ronell Eduardo Bologna-Molina, Ycenna Ailed Hernández-Miramontes, Juan Ramón Zapata-Morales, Angel Jobsabad Alonso-Castro, Flavio Martínez-Morales, Sergio Sánchez-Enriquez, Nicolás Addiel Serafín-Higuera, Guillermo Pérez-Cortez, Lorenzo Franco-de la Torre
AIMS: The purpose of this meta-analysis was to evaluate the clinical efficacy of non-steroidal anti-inflammatory drugs and dexamethasone on the trismus, postsurgical pain, facial swelling, as well as the analgesic consumption after third molar surgery. MATERIAL AND METHODS: The reports were identified in the most important medical databases. Those studies that met the requirements were fully assessed according to the inclusion and exclusion criteria. The quality of each report was evaluated with the Oxford Quality Scale and using the Cochrane Collaboration's risk of bias tool...
June 26, 2018: Drug Research
Vivian Soetikno, Shinta Dewi Permata Sari, Lulu Ul Maknun, Nielda Kezia Sumbung, Deliana Nur Ihsani Rahmi, Bashar Adi Wahyu Pandhita, Melva Louisa, Ari Estuningtyas
OBJECTIVE: In addition to oxidative stress, inflammation and apoptosis have an important role in the pathogenesis of cisplatin-induced kidney damage. This study aimed to investigate the molecular mechanisms of protective effects of curcumin against cisplatin-induced kidney inflammation and apoptosis in rats. MATERIALS AND METHODS: Eighteen rats were equally divided into three groups; normal (0.5% CMC-Na), cisplatin (CDPP) (7 mg/kg i.p.), and cisplatin+curcumin (CMN100) groups...
June 26, 2018: Drug Research
Abdulwasiu A Busari, Abdullahi A Adejare, Abiodun F Shodipe, Oludaisi A Oduniyi, Khadijah B Ismail-Badmus, Ibrahim A Oreagba
BACKGROUND: Cisplatin is an anti-cancer drug that causes nephrotoxicity and oxidative stress. Extracts of Nigella sativa is nephroprotective. Vitamin E is also a potent antioxidant. This study sought to determine a possible synergistic effect of administering the two agents prior to cisplatin use on nephrotoxicity and oxidative stress. METHODS: 48 male Wistar rats were randomly divided into 6 groups of 8 rats each. Group I served as the control. Group II received cisplatin without any treatment for 6 days...
June 26, 2018: Drug Research
Akinwale Modupe Akinjiola, Oluwatoyin Oluwasola Ajala, Oluwasanmi Olayinka Aina, Victor Olawale Oyebanji, Johnny Olufemi Olukunle
BACKGROUND: The effects of methanol extract of Parquetina nigrescens were studied on histomorphometry and protein expression (SDS-PAGE) from the ovaries and uteri of wistar rats. METHODS: 30 sexually matured rats were used for the study with 10 each in the control and treatment 100 mgkg-1 and 400 mgkg-1 groups. The extract was orally administered for 14 days. Histological sections of tissues collected presented no abnormalities. RESULTS: An increase in the number of developing and matured follicles were observed during the study in the treated groups compared to the control in the follicular and the luteal phases...
June 26, 2018: Drug Research
Temidayo Olutayo Omóbòwálé, Ademola Adetokunbo Oyagbemi, Blessing Seun Ogunpolu, Olufunke Eunice Ola-Davies, Johnny Olufemi, Olukunle Ebunoluwa Racheal Asenuga, Temitayo Olabisi Ajibade, Olumuyiwa Abiola Adejumobi, Jeremiah Moyinoluwa Afolabi, Olufunke Olubunmi Falayi, Anofi Ashafa, Adeolu Alex Adedapo, Momoh Audu Yakubu
Azadirachta indica (AI) is a medicinal plant with reported antioxidant and cardio-protective properties. The use of plant-based polyphenols has become greatly increased in the last one decade. The present study investigated the protective effect of the polyphenol-rich fraction (PRF) of the methanol-extract of Azadirachta indica against Nω -Nitro-L-Arginine Methyl Ester (L-NAME) induced hypertension and cardiorenal dysfunction in rats. Fifty (50) Wistar albino rats were grouped into five groups. Group A, the control, was administered potable water...
June 19, 2018: Drug Research
Mina Chatran, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Leila Faramarzi, Sara Rasouli, Davoud Jafari-Gharabaghlou, Navid Asbaghi, Nosratollah Zarghami
BACKGROUND: There is a growing body of data that chemotherapeutic combination strategies would be more effective in reducing drug toxicity, inhibiting tumor progression in comparison to either drug alone. OBJECTIVE: To explore a chemopreventive strategy for improving breast cancer treatment efficacy, the anticancer effects of a combination of Metformin (MET) and Silibinin (SIL) were investigated in T47D breast cancer cells. MATERIALS AND METHODS: Cytotoxicity of the drugs individually and in combination was evaluated using MTT assay...
June 19, 2018: Drug Research
Budi Prasaja, M Maulana Syabani, Endah Sari, Uci Chilmi, Prawitasari Cahyaningsih, Theresia Weliana Kosasih
Sevelamer carbonate is a cross-linked polymeric amine; it is the active ingredient in Renvela® tablets. US FDA provides recommendation for demonstrating bioequivalence for the development of a generic product of sevelamer carbonte using in-vitro equilibrium binding study. A simple UV-vis spectrophotometry method was developed and validated for quantification of free phosphate to determine the binding parameter constant of sevelamer. The method validation demonstrated the specificity, limit of quantification, accuracy and precision of measurements...
June 12, 2018: Drug Research
Prasun Mukherjee, Asish R Das, Raghwendra Mishra, Shovonlal Bhowmick, Achintya Saha
We have evaluated the LDH inhibitory property of novel pyrazolo[4',3':5,6][1,4]oxathiino[2,3-b]pyrazine derivatives which have been synthesized from easily available starting materials through a one-pot protocol that offers the use of elemental sulfur as the sulfur source. These newly synthesized compounds may aid to drug development for neoplastic and non-neoplastic diseases characterized by increased glucose metabolism. Additionally, they may act as suitable starting materials which can be further structurally modified for the development of new LDH inhibitors with higher efficacy and specificity...
June 12, 2018: Drug Research
Fauzul Husna, Franciscus D Suyatna, Wawaimuli Arozal, Erni H Poerwaningsih
AIM AND OBJECTIVE: The present study aims to investigate whether the antihyperglycemic effect of Murraya koenigii is mediated by antioxidant properties and insulin mimetic effect. METHODS: Thirty Spraque - Dawley rats were induced hyperglycemia by streptozotocin and nicotinamide (STZ-NA). The STZ-NA diabetic rats were treated with an ethanolic extract of Murraya koenigii 200 mg/kg b.w and 400 mg/kg b.w. One group was treated with glibenclamide (1 mg/kg b.w)...
May 25, 2018: Drug Research
Franziska G Leifer, Donna M Konicek, Kuan-Ju Chen, Adam J Plaunt, Dany Salvail, Charles E Laurent, Michel R Corboz, Zhili Li, Richard W Chapman, Walter R Perkins, Vladimir S Malinin
Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary arterial hypertension, requires continuous infusion or multiple dosing sessions per day for inhaled and oral routes of administration due to its short half-life. The inhaled drug is known to induce adverse systemic and local effects including headache, nausea, cough, and throat irritation which may be due at least in part to transiently high drug concentrations in the lungs and plasma immediately following administration [1]...
May 23, 2018: Drug Research
Kun Zhao, Ming Yang, Yanxia Lu, Shusen Sun, Wei Li, Xingang Li, Zhigang Zhao
BACKGROUND AND STUDY AIM: Some studies have reported an association between P2Y12 gene polymorphisms and clopidogrel adverse outcomes with inconsistent results. We aimed to explore the relationship between P2Y12 polymorphisms and the risk of adverse clinical events in patients treated with clopidogrel through a meta-analysis. METHODS: A systematic search of PubMed, Web of Science and the Cochrane Library was conducted. Retrieved articles were comprehensively reviewed and eligible studies were included, and the relevant data was extracted for this meta-analysis...
May 23, 2018: Drug Research
Abdel Naser Zaid, Naser Shraim, Asmaa Radwan, Nidal Jaradat, Samah Hirzallah, Ibrahim Issa, Aya Khraim
BACKGROUND: Many generic pharmaceutical products are currently available on the market place worldwide. Recently, there is a growing concern on the quality and efficacy of generic products. However, health care professionals such as physicians and pharmacists are in difficult situations to choose among alternatives. PURPOSE: The aim of this study is to assess the effectiveness of the in silico technique (Gastro Plus® ) in the biowaiver study and whether similarity and dissimilarity factors ( f 2 and f 1 respectively) are effective in this regard...
May 23, 2018: Drug Research
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