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Annals of the American Thoracic Society

Robert P Young, Raewyn J Hopkins
No abstract text is available yet for this article.
July 17, 2018: Annals of the American Thoracic Society
Teresa To, Jingqin Zhu, Natasha Gray, Laura Y Feldman, Paul J Villeneuve, Christopher Licskai, Andrea Gershon, Anthony B Miller
RATIONALE: Women with asthma are at a high risk of developing COPD, or asthma and COPD overlap syndrome (ACOS) as they age, which is a condition associated with a high mortality rate, low quality of life, and high healthcare costs. However, factors influencing the development of ACOS remain unclear. OBJECTIVE: To quantify the risk of developing COPD in Ontario women with asthma and identify factors that are associated with increased risk. METHODS: Data for Ontario women with asthma who participated in the Canadian National Breast Screening Study from 1980─1985 were linked to health administrative databases and participants were followed from 1992─2015...
July 17, 2018: Annals of the American Thoracic Society
Conor P Kerley
No abstract text is available yet for this article.
July 17, 2018: Annals of the American Thoracic Society
Gonzalo Labarca, Erik Folch, Michael Jantz, Hiren J Mehta, Adnan Majid, Sebastian Fernandez-Bussy
BACKGROUND: Endobronchial ultrasound and transbronchial needle aspiration (EBUS-TBNA) are commonly used for the diagnosis and mediastinal staging of lung cancer. Molecular markers are becoming increasingly important in patients with lung cancer to define targetable mutations suitable for personalized therapy, such as EGFR, ALK, ROS-1, and PD-L1. OBJECTIVE: To evaluate the adequacy of EBUS-TBNA derived tissue for molecular analysis. DATA SOURCES: We searched MEDLINE, Lilacs, clinicaltrials...
July 16, 2018: Annals of the American Thoracic Society
Morgan I Soffler, Dru D Claar, Jakob I McSparron, Daniel N Ricotta, Margaret M Hayes
No abstract text is available yet for this article.
July 16, 2018: Annals of the American Thoracic Society
Matthew Jankowich, Beth Elston, Qing Liu, Siddique Abbasi, Wen-Chih Wu, Chad Blackshear, Mark Godfrey, Gaurav Choudhary
RATIONALE: Although COPD has been related to heart failure, the relationship between the restrictive spirometry pattern (FVC<80% predicted with preserved FEV1/FVC ratio) and heart failure is poorly understood. OBJECTIVE: To determine whether having a restrictive spirometry pattern is associated with incident heart failure hospitalization. METHODS: Community-dwelling African-Americans from the Jackson Heart Study (total n=5,306; analyzed n=4,210 with spirometry and heart failure outcome data) were grouped by restrictive (FEV1/FVC≥0...
July 16, 2018: Annals of the American Thoracic Society
Anna M Baker, Janet T Holbrook, Abebaw M Yohannes, Michelle N Eakin, Elizabeth A Sugar, Robert J Henderson, Anne S Casper, David A Kaminsky, Alexis L Rea, Anne M Mathews, Loretta G Que, Joe W Ramsdell, Lynn B Gerald, Robert A Wise, Nicola A Hanania
RATIONALE: Anxiety is a common co-morbidity of Chronic Obstructive Pulmonary Disease (COPD) that is associated with higher morbidity and mortality. We evaluated three anxiety screening questionnaires, the Generalized Anxiety Disorder (GAD-7) questionnaire, the Hospital Anxiety and Depression Scale (HADS-A), and the Anxiety Inventory for Respiratory Disease (AIR). OBJECTIVES: Evaluate and compare thet test performance characteristics of 3 anxiety screening questionnaires using the Mini International Neuropsychiatric Interview (MINI) version 7...
July 9, 2018: Annals of the American Thoracic Society
Hui-Ju Tsai, Guoying Wang, Xiumei Hong, Tsung-Chieh Yao, Yuelong Ji, Sally Radovick, Hongkai Ji, Tina L Cheng, Xiaobin Wang
RATIONALE: The prevalence of childhood asthma has been rising worldwide in parallel with childhood obesity. OBJECTIVES: We investigated whether there is a temporal relationship between early-life weight gain (reflecting growth velocity) and early-life BMI attained status (reflecting accumulative weight) with future risk of asthma in the Boston Birth Cohort (BBC). METHODS: This report includes 1,928 children from the BBC with a mean age of 7...
July 6, 2018: Annals of the American Thoracic Society
Matthew J Hegewald, Dave S Collingridge, Thomas W DeCato, Robert L Jensen, Alan H Morris
RATIONALE: Current guidelines recommend using FEV1 % predicted to categorize the severity of airflow obstruction. There are limitations of using of FEV1 % predicted for this purpose including bias associated with demographic factors and the inability to correct for "lung size." Other methods for grading the severity of airflow obstruction have been proposed to address these limitations. OBJECTIVES: Our objective was to categorize airflow obstruction severity using these methods and then determine which method results in a categorization most closely associated with mortality...
July 6, 2018: Annals of the American Thoracic Society
Katherine A James, Matthew Strand, Mika K Hamer, Lisa Cicutto
RATIONALE: The San Luis Valley in rural Colorado often has elevated levels of ambient particulate matter. To date little is known about the impact of ambient particulate matter levels and medical care utilization due to asthma exacerbation in rural communities. OBJECTIVES: We investigated the impact of ambient particulate matter concentrations on emergent/urgent visits and hospitalizations for asthma in a rural community. METHODS: Daily ambient particulate matter concentrations from an air quality monitor in the San Luis Valley (2003-2012) were obtained from the state health department...
July 6, 2018: Annals of the American Thoracic Society
Mark E Fenton, Brian L Graham, Sanja Stanojevic, Lorna Whitford, Laurie Ironstand
No abstract text is available yet for this article.
June 27, 2018: Annals of the American Thoracic Society
Kristin E Schwab, Bonnie Ronish, Dale M Needham, An Q To, Jennifer L Martin, Biren B Kamdar
RATIONALE: Poor sleep quality is common in the intensive care unit (ICU) and may be associated with adverse outcomes. Hence, ICU-based efforts to promote sleep are gaining attention, motivating interest in methods to measure sleep in critically ill patients. Actigraphy evaluates rest and activity by algorithmically processing gross motor activity data, usually collected by a non-invasive wristwatch-like accelerometer device. In critically ill patients, actigraphy has been used as a surrogate measure of sleep, however its use has not been systematically reviewed...
June 26, 2018: Annals of the American Thoracic Society
Laura Fonseca, Allan J Walkey, Xiaoyue Ma, May Hua
No abstract text is available yet for this article.
June 26, 2018: Annals of the American Thoracic Society
Sameer Desai, Hubert Wong, Jenna Sykes, Anne L Stephenson, Joel Singer, Bradley S Quon
RATIONALE: Individuals diagnosed with cystic fibrosis (CF) as adults represent a growing sub-population of CF cases but there are limited studies describing their characteristics and prognosis. OBJECTIVES: The objectives of this study were to describe the clinical characteristics, estimate survival, and identify clinical predictors of reduced survival at baseline in individuals with adult-diagnosed CF. METHODS: The Canadian CF Patient Registry was utilized to identify CF patients that were ≥18 years of age at diagnosis and newly diagnosed between 1990 and 2014...
June 26, 2018: Annals of the American Thoracic Society
Maggie A Middleton, Mehdi Layeghifard, Michelle Klingel, Sanja Stanojevic, Yvonne C W Yau, James E A Zlosnik, Adele Coriati, Felix A Ratjen, Elizabeth D Tullis, Anne Stephenson, Pearce Wilcox, Andreas Freitag, Mark Chilvers, Martha McKinney, Annick Lavoie, Pauline W Wang, David S Guttman, Valerie J Waters
RATIONALE: The extent of the genetic relatedness among Pseudomonas aeruginosa isolates and its impact on clinical outcomes in the cystic fibrosis (CF) population is poorly understood. OBJECTIVES: The objectives of this study were to determine the prevalence of clonal P. aeruginosa infection in Canada and to associate P. aeruginosa genotypes with clinical outcomes. METHODS: This was an observational study of adult and pediatric CF patients across Canada...
June 18, 2018: Annals of the American Thoracic Society
Jennifer Adjemian, Kenneth N Olivier, D Rebecca Prevots
RATIONALE: Pulmonary nontuberculous mycobacterial (NTM) disease represents a significant threat to cystic fibrosis (CF) patients, with an estimated annual prevalence of 12%. Prior studies report an increasing annual NTM prevalence in the general population, though similar trends in persons with CF have not been assessed. OBJECTIVES: This study aimed to identify the prevalence, geographic patterns, temporal trends and risk factors for NTM positivity by mycobacterial species among persons with CF throughout the United States...
June 13, 2018: Annals of the American Thoracic Society
Dinh S Bui, Haydn E Walters, John A Burgess, Jennifer L Perret, Minh Q Bui, Gayan Bowatte, Adrian J Lowe, Melissa A Russell, Bruce R Thompson, Garun S Hamilton, Alan L James, Graham G Giles, Paul S Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A Frith, Katrina J Allen, Michael J Abramson, Caroline J Lodge, Shyamali C Dharmage
RATIONALE: Childhood risk factors for long-term lung health often co-exist and their specific patterns may affect subsequent lung function differently. OBJECTIVES: To identify childhood risk factor profiles, their influence on lung function and chronic obstructive pulmonary disease (COPD) in middle-age and potential pathways. METHODS: Profiles of 11 childhood respiratory risk factors, documented at age 7, were identified in 8352 participants from the Tasmanian Longitudinal Health Study using latent class analysis...
June 12, 2018: Annals of the American Thoracic Society
Benjamin W Dean, Erin E Birnie, G A Whitmore, Katherine L Vandemheen, Louis-Philippe Boulet, J Mark FitzGerald, Martha Ainslie, Samir Gupta, Catherine Lemiere, Stephen K Field, R Andrew McIvor, Paul Hernandez, Irvin Mayers, Shawn D Aaron
RATIONALE: The reliability of using between-visit variation in FEV1 to diagnose asthma is understudied, and hence uncertain. OBJECTIVE: To determine if FEV1 variability measured over recurrent visits is significantly associated with a diagnosis of current asthma. METHODS: Randomly-selected adults (N=964) with a history of physician-diagnosed asthma were studied from 2005-2007 and from 2012-2016. A diagnosis of current asthma was confirmed in those participants who exhibited bronchial hyper-responsiveness to methacholine and/or acute worsening of asthma symptoms while being weaned off asthma medications...
June 7, 2018: Annals of the American Thoracic Society
Jaimee L Heffner, Paul Krebs, Hannah Johnson, Preston A Greene, Deborah E Klein, Laura C Feemster, Christopher G Slatore, David H Au, Steven B Zeliadt
No abstract text is available yet for this article.
June 7, 2018: Annals of the American Thoracic Society
Muhammad S Ali, Jaskaran Sethi, Amit Taneja, Ali Musani, Fabien Maldonado
RATIONALE: Indeterminate peripheral pulmonary lesions often require tissue diagnosis. If non-surgical biopsy techniques are considered, deciding between bronchoscopic transbronchial vs. CT guided transthoracic biopsy can be difficult. The former has a low diagnostic yield with a low complication risk, while the latter has a better diagnostic yield but a higher complication rate. Investigators have looked at various lesion characteristics that can predict the diagnostic yield of guided bronchoscopic biopsies...
June 7, 2018: Annals of the American Thoracic Society
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