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Annals of the American Thoracic Society

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https://www.readbyqxmd.com/read/28731362/greater-cognitive-deficits-with-sleep-disordered-breathing-among-individuals-with-genetic-susceptibility-to-alzheimer-s-disease-the-multi-ethnic-study-of-atherosclerosis
#1
Dayna A Johnson, Jacqueline Lane, Rui Wang, Michelle Reid, Ina Djonlagic, Annette L Fitzpatrick, Stephen R Rapp, Luenda E Charles, Ruth O'Hara, Richa Saxena, Susan Redline
RATIONALE: There are conflicting findings regarding the link between sleep apnea and cognitive dysfunction. OBJECTIVE: Investigate associations between indicators of sleep-disordered breathing (SDB) and cognitive function in the Multi-Ethnic Study of Atherosclerosis and assess effect modification by the apolipoprotein ε-4 (APOE-ε4) allele. METHODS: A diverse population (N=1,752) underwent Type 2 in-home polysomnography, which included measurement of % sleep time <90% oxyhemoglobin saturation (%Sat<90%) and apnea-hypopnea index (AHI)...
July 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28723255/combining-efforts-for-positive-progress-in-the-gme-match-process
#2
Heath D White, Bobbie Ann Adair White, Shekhar Ghamande, Alejandro C Arroliga
No abstract text is available yet for this article.
July 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28723246/reply-combining-efforts-for-positive-progress-in-the-gme-match-process
#3
Gabriel T Bosslet, John D Buckley
none.
July 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28723245/reply-combining-efforts-for-positive-progress-in-the-gme-match-process
#4
Geneva Tatem, Maria Kokas, Cathy L Smith, Bruno DiGiovine
No abstract text is available yet for this article.
July 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28719755/clinical-risk-factors-and-prognostic-model-for-primary-graft-dysfunction-after-lung-transplantation-in-patients-with-pulmonary-hypertension
#5
Mary K Porteous, James C Lee, David J Lederer, Scott M Palmer, Edward Cantu, Rupal J Shah, Scarlett L Bellamy, Vibha N Lama, Sangeeta M Bhorade, Maria M Crespo, John F McDyer, Keith M Wille, A Russell Localio, Jonathan B Orens, Pali D Shah, Ann B Weinacker, Selim Arcasoy, David S Wilkes, Lorraine B Ware, Jason D Christie, Steven M Kawut, Joshua M Diamond
RATIONALE: Pulmonary hypertension from pulmonary arterial hypertension or parenchymal lung disease is associated with an increased risk of primary graft dysfunction after lung transplantation. OBJECTIVE: We evaluated the clinical determinants of severe primary graft dysfunction in pulmonary hypertension and developed and validated a prognostic model. METHODS: We conducted a retrospective cohort study of patients in the multi-center Lung Transplant Outcomes Group with pulmonary hypertension at transplant listing...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28719753/exercise-prescriptions-for-training-and-rehabilitation-in-patients-with-heart-and-lung-disease
#6
Pietro Palermo, Ugo Corrà
Rehabilitation in patients with advanced cardiac and pulmonary disease has been shown to increase survival and improve quality of life among many other benefits. Exercise training is the fundamental ingredient in these rehabilitation programs. However, determining the amount of exercise is not straightforward or uniform. Most rehabilitation and training program fix the time of exercise and set the exercise intensity to the goals of the rehabilitation program and the exercise-related hurdles of the individual...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28719233/bronchoscopic-management-of-airway-compression-due-to-fibrosing-mediastinitis
#7
Ryan Kern, Tobias Peikert, Eric Edell, John Mullon, David Midthun, James Utz, Fabien Maldonado
No abstract text is available yet for this article.
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28719228/successful-use-of-noninvasive-ventilation-in-chronic-obstructive-pulmonary-disease-how-do-high-performing-hospitals-do-it
#8
Kimberly A Fisher, Kathleen M Mazor, Sarah Goff, Mihaela S Stefan, Penelope S Pekow, Lauren A Williams, Vida Rastegar, Michael B Rothberg, Nicholas S Hill, Peter K Lindenauer
RATIONALE: Noninvasive ventilation (NIV) is a cornerstone of treatment for patients with severe exacerbations of chronic obstructive pulmonary disease (COPD) where it has been shown to reduce the need for intubation, hospital length of stay, and mortality. Despite high quality evidence and strong recommendations in clinical guidelines, use of NIV varies widely across hospitals. OBJECTIVE: To identify approaches used by hospitals which have been successful in implementing NIV to treat patients with severe exacerbations of COPD...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28719225/association-between-social-support-and-self-care-behaviors-in-adults-with-chronic-obstructive-pulmonary-disease
#9
Zijing Chen, Vincent S Fan, Basia Belza, Kenneth Pike, Huong Q Nguyen
RATIONALE: Higher social support is associated with a better quality of life and functioning in adults with chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine the association between structural and functional social support and self-care behaviors in adults with COPD. METHODS: This was a longitudinal study using data from the CASCADE (COPD Activity: Serotonin Transporter, Cytokines, and Depression) study which was focused on depression and functioning in COPD...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28708423/procalcitonin-test-availability-a-survey-of-acute-care-hospitals-in-massachusetts
#10
Kimberly A Fisher, Valentina Landyn, Peter K Lindenauer, Allan J Walkey
No abstract text is available yet for this article.
July 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28708421/relationship-between-race-and-the-effect-of-fluids-on-long-term-mortality-after-acute-respiratory-distress-syndrome-secondary-analysis-of-the-nhlbi-fluid-and-catheter-treatment-trial
#11
Sarah E Jolley, Catherine L Hough, Gilles Clermont, Douglas Hayden, Suqin Hou, David Schoenfeld, Nicholas L Smith, Boyd Taylor Thompson, Gordon R Bernard, Derek C Angus
RATIONALE: Short-term follow up in the Fluid and Catheter Treatment Trial (FACTT) suggested differential mortality by race with conservative fluid management, but no significant interaction. OBJECTIVE: In a post-hoc analysis of FACTT including one-year follow up, we sought to estimate long-term mortality by race and test for an interaction between fluids and race. METHODS: Post-hoc analysis of FACTT and the Economic Analysis of Pulmonary Artery Catheters (EAPAC) study (included 655 of the 1000 FACTT patients with near complete one-year follow up)...
July 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28708417/association-of-antibiotics-airway-microbiome-and-inflammation-in-infants-with-cystic-fibrosis
#12
Jessica E Pittman, Kristine M Wylie, Kathryn Akers, Gregory A Storch, Joseph Hatch, Jane Quante, Katherine B Frayman, Nadeene Clarke, Miriam Davis, Stephen M Stick, Graham L Hall, Gregory Montgomery, Sarath Ranganathan, Stephanie D Davis, Thomas W Ferkol
RATIONALE: The underlying defect in the cystic fibrosis (CF) airway leads to defective mucociliary clearance and impaired bacterial killing, resulting in endobronchial infection and inflammation that contributes to progressive lung disease. Little is known about the respiratory microbiota in the early CF airway and its relationship to inflammation. OBJECTIVES: To examine the bacterial microbiota and inflammatory profiles in bronchoalveolar lavage fluid and oropharyngeal secretions in infants with CF...
July 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28696775/dry-powder-inhalers-and-humidity-another-factor-to-consider-to-ensure-adequate-lung-delivery
#13
Roy A Pleasants
None required for a Letter to the Edittor.
July 11, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28683215/monitoring-lung-cancer-screening-utilization-and-outcomes-in-four-cancer-research-network-sites
#14
Michael K Gould, Lori C Sakoda, Debra P Ritzwoller, Michael J Simoff, Christine M Neslund-Dudas, Lawrence H Kushi, Lisa Carter-Harris, Heather Spencer Feigelson, George Minowada, V Paul Doria-Rose
RATIONALE: Lung cancer screening registries can monitor screening outcomes and improve quality of care. OBJECTIVES: To describe nascent lung cancer screening programs and share efficient data collection approaches for mandatory registry reporting in four integrated health care systems of the NCI-funded Cancer Research Network. METHODS: We documented the distinctive characteristics of lung cancer screening programs, provided examples of strategies to facilitate data collection, and described early challenges and possible solutions...
July 6, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28679061/mechanisms-that-modulate-peripheral-oxygen-delivery-during-exercise-in-heart-failure
#15
Tomohiko Kisaka, William W Stringer, Akira Koike, Piergiuseppe Agostoni, Karlman Wasserman
Oxygen uptake (V̇O2) measured at the mouth, which is equal to the cardiac output (C.O.) times the arterial-venous oxygen content difference [C(a-v)O2) ], increases over 10-20 fold in normal subjects during exercise. To achieve this substantial increase in oxygen uptake (V̇O2) = C.O. x C(a-v)O2) ) both cardiac output and arterial-venous difference must simultaneously increase. While this occurs in normal subjects, patients with heart failure cannot achieve significant increases in cardiac output and must rely primarily on changes in arterial-venous difference to increase V̇O2) during exercise...
July 5, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28644698/sleep-disturbance-after-hospitalization-and-critical-illness-a-systematic-review
#16
Marcus T Altman, Melissa P Knauert, Margaret A Pisani
BACKGROUND: Sleep disturbance during intensive care unit (ICU) admission is common and severe. Sleep disturbance has been observed in survivors of critical illness even after transfer out of the ICU. Not only is sleep important to overall health and well-being, but patients after critical illness are also in a physiologically vulnerable state. Understanding how sleep disturbance impacts recovery from critical illness after hospital discharge is therefore clinically meaningful. OBJECTIVE: This systematic review aimed to summarize studies that identify the prevalence of and risk factors for sleep disturbance after hospital discharge for critical illness survivors...
June 23, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28644693/supplemental-oxygen-in-interstitial-lung-disease-an-art-in-need-of-science
#17
Kerri A Johannson, Sachin R Pendharkar, Kirk Mathison, Charlene D Fell, Jordan A Guenette, Meena Kalluri, Martin Kolb, Christopher J Ryerson
Interstitial lung disease (ILD) comprises a large and heterogeneous group of disorders that often lead to progressive fibrosis and premature death. Oxygen supplementation is typically used in advanced lung disease patients with resting hypoxemia; however, there is a paucity of evidence guiding the use of supplemental oxygen in ILD, and significant heterogeneity in clinical practice. It remains unclear whether supplemental oxygen improves clinically meaningful outcomes, and the role of ambulatory oxygen supplementation in isolated exertional hypoxemia is particularly controversial...
June 23, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28640670/rationale-and-design-of-the-lung-cancer-screening-implementation-evaluation-of-patient-centered-care-study
#18
Leah S Miranda, Santanu Datta, Anne C Melzer, Renda Soylemez Wiener, James M Davis, Betty C Tong, Sara E Golden, Christopher G Slatore
Screening for lung cancer using low-dose computed tomography (LDCT) has been demonstrated to reduce lung cancer-related mortality and is being widely implemented. Further research in this area is needed to assess the impact of screening on patient-centered outcomes. Here we describe the design and rationale for a new study entitled Lung Cancer Screening Implementation: Evaluation of Patient-Centered Care. The protocol is composed of an interconnected series of studies evaluating patients and clinicians who are engaged in lung cancer screening in real-world settings...
June 22, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28640655/usual-interstitial-pneumonia-can-be-detected-in-transbronchial-biopsies-using-machine-learning
#19
Daniel G Pankratz, Yoonha Choi, Urooj Imtiaz, Grażyna M Fedorowicz, Jessica D Anderson, Thomas V Colby, Jeffrey L Myers, David A Lynch, Kevin K Brown, Kevin R Flaherty, Mark P Steele, Steve D Groshong, Ganesh Raghu, Neil M Barth, P Sean Walsh, Jing Huang, Giulia C Kennedy, Fernando J Martinez
RATIONALE: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis. While UIP can be detected by high-resolution computed tomography (HRCT) of the chest, HRCT results are frequently inconclusive, and pathology from transbronchial biopsy (TBB) has poor sensitivity. Surgical lung biopsy (SLB) may be necessary for a definitive diagnosis. OBJECTIVES: To develop a genomic classifier in tissue obtained by TBB that distinguishes UIP from non-UIP, trained against central pathology as the reference standard...
June 22, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28622018/reply-less-is-more-approach-for-management-of-intrapleural-sepsis
#20
Natalia Popowicz, Rajesh Thomas, Y C Gary Lee
No abstract text is available yet for this article.
June 16, 2017: Annals of the American Thoracic Society
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