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BioMed Research International

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https://www.readbyqxmd.com/read/28428963/quercetin-inhibits-pulmonary-arterial-endothelial-cell-transdifferentiation-possibly-by-akt-and-erk1-2-pathways
#1
Shian Huang, Xiulong Zhu, Wenjun Huang, Yuan He, Lingpin Pang, Xiaozhong Lan, Xiaorong Shui, Yanfang Chen, Can Chen, Wei Lei
This study aimed to investigate the effects and mechanisms of quercetin on pulmonary arterial endothelial cell (PAEC) transdifferentiation into smooth muscle-like cells. TGF-β1-induced PAEC transdifferentiation models were applied to evaluate the pharmacological actions of quercetin. PAEC proliferation was detected with CCK8 method and BurdU immunocytochemistry. Meanwhile, the identification and transdifferentiation of PAECs were determined by FVIII immunofluorescence staining and α-SMA protein expression...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28428962/a-higher-ovarian-response-after-stimulation-for-ivf-is-related-to-a-higher-number-of-euploid-embryos
#2
Elena Labarta, Ernesto Bosch, Amparo Mercader, Pilar Alamá, Emilia Mateu, Antonio Pellicer
This study has analysed the relationship between ovarian response and the number of euploid embryos. This is a post hoc analysis of a subset of data generated during a prospective cohort study previously published. Forty-six oocyte donors were subjected to ovarian stimulation with 150 IU of rFSH and 75 IU of hp-hMG in a GnRH agonist long protocol. Preimplantation genetic screening was performed in all viable embryos. We observed a positive relationship between ovarian response and the number of euploid embryos...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28428961/glucose-insulin-potassium-alleviates-intestinal-mucosal-barrier-injuries-involving-decreased-expression-of-uncoupling-protein-2-and-nlr-family-pyrin-domain-containing-3-inflammasome-in-polymicrobial-sepsis
#3
Jun-Liang Zhang, Yi-Ting Chen, Guang-Dao Chen, Tao Wang, Ju-Xin Zhang, Qi-Yi Zeng
Uncoupling protein 2 (UCP2) may be critical for intestinal barrier function which may play a key role in the development of sepsis, and insulin has been reported to have anti-inflammatory effects. Male Sprague-Dawley rats were randomly allocated into five groups: control group, cecal ligation and puncture (CLP) group, sham surgery group, CLP plus glucose-insulin-potassium (GIK) group, and CLP plus glucose and potassium (GK) group. Ileum tissues were collected at 24 h after surgery. Histological and cytokine analyses, intestinal permeability tests, and western blots of intestinal epithelial tight junction component proteins and UCP2 were performed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28428960/microrna-and-cardiovascular-disease-2016
#4
EDITORIAL
Ling-Qing Yuan, Vinicio de Jesus Perez, Xiao-Bo Liao, Magdalena Król, Chi-Hsiao Yeh
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28428959/copy-number-variations-in-candidate-genes-and-intergenic-regions-affect-body-mass-index-and-abdominal-obesity-in-mexican-children
#5
Diana Lizzete Antúnez-Ortiz, Eugenia Flores-Alfaro, Ana Isabel Burguete-García, Amélie Bonnefond, Jesús Peralta-Romero, Philippe Froguel, Mónica Espinoza-Rojo, Miguel Cruz
Introduction. Increase in body weight is a gradual process that usually begins in childhood and in adolescence as a result of multiple interactions among environmental and genetic factors. This study aimed to analyze the relationship between copy number variants (CNVs) in five genes and four intergenic regions with obesity in Mexican children. Methods. We studied 1423 children aged 6-12 years. Anthropometric measurements and blood levels of biochemical parameters were obtained. Identification of CNVs was performed by real-time PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424791/antifatigue-effects-of-antrodia-cinnamomea-cultured-mycelium-via-modulation-of-oxidative-stress-signaling-in-a-mouse-model
#6
Yange Liu, Lanzhou Li, Shengshu An, Yuanzhu Zhang, Shiwei Feng, Lu Zhao, Lirong Teng, Di Wang
Antrodia cinnamomea, a folk medicinal mushroom, has numerous biological effects. In this study, we aim to assess whether the antifatigue effects of A. cinnamomea mycelia (AC) and its underlying mechanisms are related to oxidative stress signaling using behavioral mouse models and biochemical indices detection. Mice were orally treated with AC at doses of 0.1, 0.3, and 0.9 g/kg for three weeks. AC had no effect on the spontaneous activities of mice indicating its safety on central nervous system. Furthermore, results obtained from weight-loaded forced swimming test, rotary rod test, and exhausted running test confirmed that AC significantly enhanced exercise tolerance of mice...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424790/development-of-isothermal-recombinase-polymerase-amplification-assay-for-rapid-detection-of-porcine-circovirus-type-2
#7
Yang Yang, Xiaodong Qin, Yingjun Sun, Guozheng Cong, Yanmin Li, Zhidong Zhang
Porcine circovirus virus type II (PCV2) is the etiology of postweaning multisystemic wasting syndrome (PMWS), porcine dermatitis, nephropathy syndrome (PDNS), and necrotizing pneumonia. Rapid diagnosis tool for detection of PCV2 plays an important role in the disease control and eradication program. Recombinase polymerase amplification (RPA) assays using a real-time fluorescent detection (PCV2 real-time RPA assay) and RPA combined with lateral flow dipstick (PCV2 RPA LFD assay) were developed targeting the PCV2 ORF2 gene...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424789/cognitive-behavioral-coping-illness-perception-and-family-adaptability-in-oncological-patients-with-a-family-history-of-cancer
#8
Roxana Postolica, Magdalena Iorga, Florin Dumitru Petrariu, Doina Azoicai
Aim. The study investigated the differences between patients with and without a family history of cancer regarding coping strategies, illness perception, and family adaptability to the disease. Material and Methods. A total of 124 patients diagnosed with cancer were included in the research (55 of them with a family history of cancer). The Cognitive Emotion Regulation Questionnaire, the Strategic Approach to Coping Scale, the Family Adaptability and Cohesion Scale, and the Illness Perception Questionnaire were applied...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424788/fully-automated-robust-system-to-detect-retinal-edema-central-serous-chorioretinopathy-and-age-related-macular-degeneration-from-optical-coherence-tomography-images
#9
Samina Khalid, M Usman Akram, Taimur Hassan, Ammara Nasim, Amina Jameel
Maculopathy is the excessive damage to macula that leads to blindness. It mostly occurs due to retinal edema (RE), central serous chorioretinopathy (CSCR), or age related macular degeneration (ARMD). Optical coherence tomography (OCT) imaging is the latest eye testing technique that can detect these syndromes in early stages. Many researchers have used OCT images to detect retinal abnormalities. However, to the best of our knowledge, no research that presents a fully automated system to detect all of these macular syndromes is reported...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424787/integrating-transcriptomics-proteomics-and-metabolomics-profiling-with-system-pharmacology-for-the-delineation-of-long-term-therapeutic-mechanisms-of-bufei-jianpi-formula-in-treating-copd
#10
Peng Zhao, Jiansheng Li, Ya Li, Yange Tian, Liping Yang, Suyun Li
In previous work, we identified 145 active compounds from Bufei Jianpi formula (BJF) by system pharmacology and found that BJF showed short-term effect on chronic obstructive pulmonary disease (COPD) rats. Here, we applied the transcriptomic, proteomic, and metabolomics approaches to illustrate the long-term anti-COPD action and its system mechanism of BJF. BJF has obvious anti-COPD effect through decreasing inflammatory cytokines level, preventing protease-antiprotease imbalance and collagen deposition on week 32 by continuous oral administration to rats from weeks 9 to 20...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424786/immunocytochemistry-improving-the-diagnosis-of-trichomonas-vaginalis-infections
#11
Thaisa Helena S Fonseca, Fabrício M Silva Oliveira, Marina Alacoque, Marcella Israel Rocha, Henrique Vitor Leite, Joseph F Guimarães Santos, Haendel G N O Busatti, Marcelo Vidigal Caliari, Maria Aparecida Gomes
The aim of this study was to evaluate the immunocytochemistry (ICC) to diagnose trichomoniasis, particularly asymptomatic infections. By culture serial dilutions, ICC was able to detect 1 trophozoite/mL, while the culture was positive up to 100 trophozoites/mL. The ICC in vivo detection capability was assessed in vaginal secretions of mice experimentally infected and in vaginal swabs from asymptomatic HIV-positive pregnant women compared with culture. All vaginal secretion samples from mice were positive according to both methods...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424785/the-impact-of-homocysteine-vitamin-b12-and-vitamin-d-levels-on-functional-outcome-after-first-ever-ischaemic-stroke
#12
Merdin Markišić, Aleksandra M Pavlović, Dragan M Pavlović
We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424784/evaluation-of-connexin-43-redistribution-and-endocytosis-in-astrocytes-subjected-to-ischemia-reperfusion-or-oxygen-glucose-deprivation-and-reoxygenation
#13
Hongyan Xie, Yu Cui, Shuai Hou, Juan Wang, Jing Miao, Fang Deng, Jiachun Feng
Connexin 43 (Cx43) is the major component protein in astrocytic gap junction communication. Recent studies have shown the cellular processes of gap junction internalization and degradation, but many details remain unknown. This study investigated the distribution of Cx43 and its mechanism after ischemic insult. Astrocyte culture system and a model of ischemia/reperfusion (IR) or oxygen-glucose deprivation and reoxygenation (OGDR) were established. Cx43 distribution was observed by laser scanning confocal microscopy under different cultivation conditions...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424783/peptide-fraction-poh2-exerts-antiadipogenic-activity-through-inhibition-of-c-ebp-%C3%AE-and-ppar-%C3%AE-expression-in-3t3-l1-adipocytes
#14
Thi Tuyet Nhung Nguyen, Thi Thu Ha, Thi Hoa Nguyen, Thi Hien Vu, Nam Hai Truong, Hoang Ha Chu, Dong Van Quyen
Many studies have comprehensively examined the venom of Ophiophagus hannah snake. Its venom comprises different compounds exhibiting a wide range of pharmacological activities. In this investigation, four peptide fractions (PFs), ranging from 3 kDa to 10 kDa, isolated from the Vietnamese snake venom of O. hannah were separated by HPLC and investigated for their inhibitory activity on adipogenesis in 3T3-L1 adipocytes. The most effective PF was then further purified, generating two peptides, pOh1 and pOh2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424782/clinical-significance-of-preoperative-albumin-and-globulin-ratio-in-patients-with-gastric-cancer-undergoing-treatment
#15
Min-Jie Mao, Xiao-Li Wei, Hui Sheng, Xue-Ping Wang, Xiao-Hui Li, Yi-Jun Liu, Shan Xing, Qi Huang, Shu-Qin Dai, Wan-Li Liu
Background. The pretreatment albumin and globulin ratio (AGR) was an inflammation-associated factor which was related to the overall survival in various malignancies. The aim of this study was to evaluate the prognostic value of AGR in patients with gastric cancer. Method. This retrospective study included 862 cases pathologically diagnosed with gastric cancer. All patients were randomly divided into the testing group (431 cases) and validation group (431 cases). The relationships of AGR with clinicopathologic characteristics and prognosis were analyzed by Kaplan-Meier and Cox regression methods...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424781/postembedding-decalcification-of-mineralized-tissue-sections-preserves-the-integrity-of-implanted-biomaterials-and-minimizes-number-of-experimental-animals
#16
Thaqif El Khassawna, Diaa Eldin S Daghma, Sabine Stoetzel, Seemun Ray, Stefanie Kern, Deeksha Malhan, Volker Alt, Ulrich Thormann, Anja Henß, Marcus Rohnke, Annette Stengel, Fathi Hassan, Stefan Maenz, Klaus D Jandt, Michael Diefenbeck, Matthias Schumacher, Michael Gelinsky, Katrin Susanne Lips, Christian Heiss
Bone histology of decalcified or undecalcified samples depends on the investigation. However, in research each method provides different information to answer the scientific question. Decalcification is the first step after sample fixation and governs what analysis is later feasible on the sections. Besides, decalcification is favored for immunostaining and in situ hybridization. Otherwise, sample decalcification can be damaging to bone biomaterials implants that contains calcium or strontium. On the other hand, after decalcification mineralization cannot be assessed using histology or imaging mass spectrometry...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28424780/corrigendum-to-influence-of-a-10-day-mimic-of-our-ancient-lifestyle-on-anthropometrics-and-parameters-of-metabolism-and-inflammation-the-study-of-origin
#17
Leo Pruimboom, Begoña Ruiz-Núñez, Charles L Raison, Frits A J Muskiet, Jens Freese
[This corrects the article DOI: 10.1155/2016/6935123.].
2017: BioMed Research International
https://www.readbyqxmd.com/read/28421203/novel-computational-approaches-and-applications-in-cancer-research
#18
EDITORIAL
Min Zhang, Lin Hua, Weiwei Zhai, Yichuan Zhao
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28421202/the-interaction-between-hiv-and-intestinal-helminth-parasites-coinfection-with-nutrition-among-adults-in-kwazulu-natal-south-africa
#19
B T Mkhize, M Mabaso, T Mamba, C E Napier, Z L Mkhize-Kwitshana
In South Africa few studies have examined the effects of the overlap of HIV and helminth infections on nutritional status. This cross-sectional study investigated the interaction between HIV and intestinal helminths coinfection with nutritional status among KwaZulu-Natal adults. Participants were recruited from a comprehensive primary health care clinic and stratified based on their HIV, stool parasitology, IgE, and IgG4 results into four groups: the uninfected, HIV infected, helminth infected, and HIV-helminth coinfected groups...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28421201/reconstructive-and-regenerative-therapy-of-atrophic-jaws-with-new-implant-techniques-preclinical-and-clinical-studies
#20
EDITORIAL
Carmen Mortellaro, Sérgio Alexandre Gehrke, Eitan Mijiritsky
No abstract text is available yet for this article.
2017: BioMed Research International
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