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BioMed Research International

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https://www.readbyqxmd.com/read/28546965/ribonuclease-from-bacillus-acts-as-an-antiviral-agent-against-negative-and-positive-sense-single-stranded-human-respiratory-rna-viruses
#1
Raihan Shah Mahmud, Christin Müller, Yulia Romanova, Ahmed Mostafa, Vera Ulyanova, Stephan Pleschka, Olga Ilinskaya
Bacillus pumilus ribonuclease (binase) was shown to be a promising antiviral agent in animal models and cell cultures. However, the mode of its antiviral action remains unknown. To assess the binase effect on intracellular viral RNA we have selected single stranded negative- and positive-sense RNA viruses, influenza virus, and rhinovirus, respectively, which annually cause respiratory illnesses and are characterized by high contagious nature, mutation rate, and antigen variability. We have shown that binase exerts an antiviral effect on both viruses at the same concentration, which does not alter the spectrum of A549 cellular proteins and expression of housekeeping genes...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28546964/application-of-the-initial-rate-method-in-anaerobic-digestion-of-kitchen-waste
#2
Lei Feng, Yuan Gao, Wei Kou, Xianming Lang, Yiwei Liu, Rundong Li, Meiling Yu, Lijie Shao, Xiaoming Wang
This article proposes a methane production approach through sequenced anaerobic digestion of kitchen waste, determines the hydrolysis constants and reaction orders at both low total solid (TS) concentrations and high TS concentrations using the initial rate method, and examines the population growth model and first-order hydrolysis model. The findings indicate that the first-order hydrolysis model better reflects the kinetic process of gas production. During the experiment, all the influential factors of anaerobic fermentation retained their optimal values...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28546963/auditory-processing-abilities-of-parkinson-s-disease-patients
#3
Robert L Folmer, Jay J Vachhani, Sarah M Theodoroff, Rachel Ellinger, Amy Riggins
Since Parkinson's Disease (PD) primarily affects older people, a majority of PD patients have age-related hearing loss (HL) that will worsen over time. The goal of this study was to assess peripheral and central auditory functions in a population of PD patients and compare the results with a group of age-matched control subjects. Study participants included 35 adults with PD (mean age = 66.9 ± 11.2 years) and a group of 35 healthy control subjects (mean age = 65.4 ± 12.3 years). Assessments included questionnaires, neuropsychological tests, audiometric testing, and a battery of central auditory processing tests...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28546962/recent-advances-of-curcumin-in-the-prevention-and-treatment-of-renal-fibrosis
#4
REVIEW
Xuejiao Sun, Yi Liu, Cheng Li, Xiting Wang, Ruyuan Zhu, Chenyue Liu, Haixia Liu, Lili Wang, Rufeng Ma, Min Fu, Dongwei Zhang, Yu Li
Curcumin, a polyphenol derived from the turmeric, has received attention as a potential treatment for renal fibrosis primarily because it is a relatively safe and inexpensive compound that contributes to kidney health. Here, we review the literatures on the applications of curcumin in resolving renal fibrosis in animal models and summarize the mechanisms of curcumin and its analogs (C66 and (1E,4E)-1,5-bis(2-bromophenyl) penta-1,4-dien-3-one(B06)) in preventing inflammatory molecules release and reducing the deposition of extracellular matrix at the priming and activation stage of renal fibrosis in animal models by consulting PubMed and Cnki databases over the past 15 years...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540307/decellularization-strategies-for-regenerative-medicine-from-processing-techniques-to-applications
#5
REVIEW
Anna Gilpin, Yong Yang
As the gap between donors and patients in need of an organ transplant continues to widen, research in regenerative medicine seeks to provide alternative strategies for treatment. One of the most promising techniques for tissue and organ regeneration is decellularization, in which the extracellular matrix (ECM) is isolated from its native cells and genetic material in order to produce a natural scaffold. The ECM, which ideally retains its inherent structural, biochemical, and biomechanical cues, can then be recellularized to produce a functional tissue or organ...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540306/quantitative-analysis-of-musculoskeletal-ultrasound-techniques-and-clinical-applications
#6
EDITORIAL
Qing Wang, Qing-Hua Huang, John T W Yeow, Mark R Pickering, Simo Saarakkala
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540305/neural-engineering-for-rehabilitation
#7
EDITORIAL
Han-Jeong Hwang, Do-Won Kim, Janne M Hahne, Jongsang Son
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540304/achilles-tendinopathy-from-the-basic-science-to-the-clinic
#8
EDITORIAL
Hong-Yun Li, Youichi Yasui, Seung Hwan Han, Wataru Miyamoto, Ying-Hui Hua
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540303/identifying-the-genes-responsible-for-iron-limited-condition-in-riemerella-anatipestifer-ch-1-through-rna-seq-based-analysis
#9
MaFeng Liu, Mi Huang, DeKang Zhu, MingShu Wang, RenYong Jia, Shun Chen, KunFeng Sun, Qiao Yang, Ying Wu, Francis Biville, AnChun Cheng
One of the important elements for most bacterial growth is iron, the bioavailability of which is limited in hosts. Riemerella anatipestifer (R. anatipestifer, RA), an important duck pathogen, requires iron to live. However, the genes involved in iron metabolism and the mechanisms of iron transport are largely unknown. Here, we investigated the transcriptomic effects of iron limitation condition on R. anatipestifer CH-1 using the RNA-Seq and RNA-Seq-based analysis. Data analysis revealed genes encoding functions related to iron homeostasis, including a number of putative TonB-dependent receptor systems, a HmuY-like protein-dependent hemin (an iron-containing porphyrin) uptake system, a Feo system, a gene cluster related to starch utilization, and genes encoding hypothetical proteins that were significantly upregulated in response to iron limitation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540302/the-elasticity-coefficients-measurement-of-human-dentin-based-on-rus
#10
Fan Fan, Dandan Feng, Rui Wang, Qiang Zhang, Haijun Niu
This paper proposed to take advantages of resonant ultrasound spectroscopy (RUS) to measure the mechanical properties of human dentin specimen. The resonant spectroscopy of the dentin specimen was obtained between the frequency bands 155 and 575 kHz, and resonant frequencies were extracted by linear predictive filter and then by Levenberg-Marquardt method. By inverse problem approach, 13 experimental resonant frequencies progressively matched to the first 30 orders of theoretical resonant frequencies calculated by Lagrangian variational method...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540301/the-risk-of-achilles-tendon-rupture-in-the-patients-with-achilles-tendinopathy-healthcare-database-analysis-in-the-united-states
#11
Youichi Yasui, Ichiro Tonogai, Andrew J Rosenbaum, Yoshiharu Shimozono, Hirotaka Kawano, John G Kennedy
Introduction. Disorders of the Achilles tendon can be broadly classified into acute and chronic entities. Few studies have established chronic Achilles tendinopathy as a precursor to acute Achilles ruptures. In this study, we assessed the relationship between Achilles tendinopathy and rupture, clarifying the incidence of rupture in the setting of underlying tendinopathy. Methods. The United Healthcare Orthopedic Dataset from the PearlDiver Patient Record Database was used to identify patients with ICD-9 codes for Achilles rupture and/or Achilles tendinopathy...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540300/extracellular-signal-regulated-kinase-5-is-required-for-low-concentration-h2o2-induced-angiogenesis-of-human-umbilical-vein-endothelial-cells
#12
Shan Jiang, Dongxin Zhang, Hong Huang, Yonghong Lei, Yan Han, Weidong Han
Background. The aim of this study was to assess the effects of low concentrations of H2O2 on angiogenesis of human umbilical vein endothelial cells (HUVECs) in vitro and explore the underlying mechanisms. Methods. HUVECs were cultured and stimulated with different concentrations of H2O2. Flow cytometric analysis was used to select an optimal concentration of H2O2 for the following experiments. Cell proliferation, migration, and tubule formation were evaluated by Cell Counting Kit-8 (CCK-8) assays, scratch wound assays, and Matrigel tubule formation assays, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540299/surface-treatment-on-physical-properties-and-biocompatibility-of-orthodontic-power-chains
#13
H C Cheng, M S Chen, B Y Peng, W T Lin, Y K Shen, Y H Wang
The conventional orthodontic power chain, often composed of polymer materials, has drawbacks such as a reduction of elasticity owing to water absorption as well as surface discoloration and staining resulting from food or beverages consumed by the patient. The goal of this study was to develop a surface treatment (nanoimprinting) for orthodontic power chains and to alleviate their shortcomings. A concave template (anodic alumina) was manufactured by anodization process using pure aluminum substrate by employing the nanoimprinting process...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540298/the-clinical-values-of-serum-markers-in-the-early-prediction-of-hepatocellular-carcinoma
#14
Bo Li, Boan Li, Tongsheng Guo, Zhiqiang Sun, Xiaohan Li, Xiaoxi Li, Han Wang, Weijiao Chen, Peng Chen, Yuanli Mao
The early prediction values of diagnostic markers for hepatocellular carcinoma (HCC) are still unclear at present. This study evaluated the prediction value of ten serum markers in HCC. A total of 109 cases of hepatic cirrhosis patients were followed up for 36 months and the relationship between the lifetime risk of developing HCC and levels of serum markers was analyzed. 31.2 (34/109) percent of hepatic cirrhosis patients developed HCC during the study's timeframe. Higher alpha-fetoprotein (AFP), alpha-fetoprotein-L3 (AFP-L3), alanine aminotransferase (ALT), and AFP-L3/AFP ratio levels are potential risk factors for malignization in hepatic cirrhosis patients (RR = 2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540297/modulation-of-progesterone-receptor-isoform-expression-in-pregnant-human-myometrium
#15
Marina Ilicic, Tamas Zakar, Jonathan W Paul
Background. Regulation of myometrial progesterone receptor (PR) expression is an unresolved issue central to understanding the mechanism of functional progesterone withdrawal and initiation of labor in women. Objectives. To determine whether pregnant human myometrium undergoes culture-induced changes in PR isoform expression ex situ and, further, to determine if conditions approaching the in vivo environment stabilise PR isoform expression in culture. Methods. Term nonlaboring human myometrial tissues were cultured under specific conditions: serum supplementation, steroids, stretch, cAMP, PMA, PGF2α , NF-κB inhibitors, or TSA...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540296/evaluation-of-the-complex-nomenclature-of-the-clinically-and-veterinary-significant-pathogen-salmonella
#16
REVIEW
Michael P Ryan, Jean O'Dwyer, Catherine C Adley
Salmonella encompasses a vast and highly related population of clinically and veterinary significant pathogens. The genus is responsible for an array of diseases such as typhoid fever and salmonellosis (a variety of illnesses including gastroenteritis), which cause public health issues globally. Even with the global recognition of Salmonella as a significant human and veterinary pathogen, the highly complex and evolving nomenclature system of Salmonella is problematic for clinicians, veterinarians, and microbiologists to comprehend...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540295/relaxin-attenuates-contrast-induced-human-proximal-tubular-epithelial-cell-apoptosis-by-activation-of-the-pi3k-akt-signaling-pathway-in-vitro
#17
Xiang-Cheng Xie, Yizhi Cao, Xiu Yang, Qun-Hong Xu, Wei Wei, Ming Wang
Background. Contrast-induced acute kidney injury (CI-AKI) is one of the main causes of iatrogenic acute kidney injury (AKI); however, therapeutic strategies for AKI remain limited. This study aims to explore the effect of relaxin (RLX) on contrast-induced HK-2 apoptosis and its underlying mechanisms. Methods. Renal tubular epithelial cells (HK-2) were incubated either with or without ioversol, human H2 relaxin, and LY294002 (the inhibitor of the PI3K/Akt signal pathway). Cell viability was evaluated with a CCK-8 assay...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540294/management-of-spontaneous-subarachnoid-hemorrhage-patients-with-negative-initial-digital-subtraction-angiogram-findings-conservative-or-aggressive
#18
Liang Xu, Yuanjian Fang, Xudan Shi, Xianyi Chen, Jun Yu, Zeyu Sun, Jianmin Zhang, Jing Xu
Background. The ideal management of SAH patients with negative initial DSA findings remains unresolved. Objective. (i) To present risk factors, clinical courses, and outcomes in different types of SAH patients with negative DSA findings; (ii) to explore the differences of basal vein between aSAH patients and NASAH patients; and (iii) to evaluate the value of repeated DSA for these patients. Methods. All SAH patients with negative initial DSA findings between 2013 and 2015 in our hospital were enrolled and were further categorized as perimesencephalic SAH (PMN-SAH) or nonperimesencephalic SAH (nPMN-SAH)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540293/altered-erythropoiesis-in-mouse-models-of-type-3-hemochromatosis
#19
R M Pellegrino, F Riondato, L Ferbo, M Boero, A Palmieri, L Osella, P Pollicino, B Miniscalco, G Saglio, A Roetto
Type 3 haemochromatosis (HFE3) is a rare genetic iron overload disease which ultimately lead to compromised organs functioning. HFE3 is caused by mutations in transferrin receptor 2 (TFR2) gene that codes for two main isoforms (Tfr2α and Tfr2β). Tfr2α is one of the hepatic regulators of iron inhibitor hepcidin. Tfr2β is an intracellular isoform of the protein involved in the regulation of iron levels in reticuloendothelial cells. It has been recently demonstrated that Tfr2 is also involved in erythropoiesis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540292/bone-tissue-engineering-scaffolds-with-osteoinductivity-for-bone-regeneration
#20
EDITORIAL
Shen Liu, Changmin Hu, Zheng Ren
No abstract text is available yet for this article.
2017: BioMed Research International
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