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BioMed Research International

Qiaoliang Li, Yuzhen Xu, Zhewei Chen, Dexiang Liu, Shi-Ting Feng, Martin Law, Yufeng Ye, Bingsheng Huang
Objectives: To evaluate the application of a deep learning architecture, based on the convolutional neural network (CNN) technique, to perform automatic tumor segmentation of magnetic resonance imaging (MRI) for nasopharyngeal carcinoma (NPC). Materials and Methods: In this prospective study, 87 MRI containing tumor regions were acquired from newly diagnosed NPC patients. These 87 MRI were augmented to >60,000 images. The proposed CNN network is composed of two phases: feature representation and scores map reconstruction...
2018: BioMed Research International
Marta Casquero-Veiga, David García-García, Manuel Desco, María Luisa Soto-Montenegro
Deep brain stimulation (DBS) is a neurosurgery technique widely used in movement disorders, although its mechanism of action remains unclear. In fact, apart from the stimulation itself, the mechanical insertion of the electrode may play a crucial role. Here we aimed to distinguish between the insertional and the DBS effects on brain glucose metabolism. To this end, electrodes were implanted targeting the medial prefrontal cortex in five adult male Wistar rats. Positron Emission Tomography (PET) studies were performed before surgery (D0) and seven (D7) and nine days (D9) after that...
2018: BioMed Research International
Samantha Wasniewski, Luciano Consuegra-Sánchez, Pablo Conesa-Zamora, Luis García de Guadiana-Romualdo, Pablo Ramos-Ruiz, Marta Merelo-Nicolás, F Guillermo Clavel-Ruipérez, Begoña Alburquerque-González, Federico Soria-Arcos, Juan A Castillo-Moreno
Background: Anticoagulation with vitamin K antagonists continues to be a challenging task given the difficulty of achieving a correct time in therapeutic range (TTR). The SAMeTT2 R2 score has been proposed to identify patients that will be good responders. In this study we aimed to analyse clinical and genetic factors involved in a correct level of anticoagulation in patients with atrial fibrillation and thereby potentially improve the diagnostic performance of SAMeTT2 R2 score. Methods: We prospectively included 212 consecutive patients with nonvalvular atrial fibrillation under treatment with acenocoumarol for at least 6 months that were attended in a cardiology outpatient clinic and were categorized as adherent to medication...
2018: BioMed Research International
Ahmed Abdulhakim Al-Absi, Najeeb Abbas Al-Sammarraie, Wael Mohamed Shaher Yafooz, Dae-Ki Kang
MapReduce is the preferred cloud computing framework used in large data analysis and application processing. MapReduce frameworks currently in place suffer performance degradation due to the adoption of sequential processing approaches with little modification and thus exhibit underutilization of cloud resources. To overcome this drawback and reduce costs, we introduce a Parallel MapReduce ( PMR ) framework in this paper. We design a novel parallel execution strategy of Map and Reduce worker nodes. Our strategy enables further performance improvement and efficient utilization of cloud resources execution of Map and Reduce functions to utilize multicore environments available with computing nodes...
2018: BioMed Research International
Xin Zhang, Fengmin Zhang, Wenbo Qiao, Xiansheng Zhang, Zhefeng Zhao, Mingqi Li
Morbidity and mortality of lung cancer rank first in China and worldwide. Thus, noninvasive prognostic biomarkers are critical for clinicians to perform risk assessment in lung cancer patients prior to or during the course of treatment. In this study, we evaluated the prognostic value of preoperative hematocrit (HCT) count reduction on the long-term survival of lung cancer patients undergoing pneumonectomy and analyzed the correlation between reduced HCT counts and patients' clinicopathological features. A total of 1022 patients who underwent surgical treatment in Harbin Medical University Cancer Hospital, China, from February 2006 to December 2013, were enrolled in this study...
2018: BioMed Research International
Shan-Shan Luo, Xi-Wen Liao, Xiao-Dong Zhu
Except for excision repair cross-complementing 1 (ERCC1), mRNA expression of the remaining ERCC genes has not been investigated in the prognosis of gastric cancer (GC). The present study aimed to explore the mRNA expression and prognostic values of each member of the ERCC family in GC patients by using the Kaplan-Meier (KM) plotter tool. The details of each ERCC family member were entered into a database and GC patients were separated into high and low expression to draw survival plots using the KM plotter...
2018: BioMed Research International
Chih-Min Su, Chia-Te Kung, Fu-Cheng Chen, Hsien-Hung Cheng, Sheng-Yuan Hsiao, Yun-Ru Lai, Chin-Cheng Huang, Nai-Wen Tsai, Cheng-Hsien Lu
Background: Several comorbidities contribute to an increased risk of infections in Parkinson's disease (PD) as the disease progresses. However, few studies have examined the correlation between sepsis and PD. Aim: The aim of this study is to disclose the presentation and outcome of serious infection in patients with PD in the emergency department. Methods: This retrospective cohort study enrolled patients with PD who had serious infection and were admitted to the emergency department between January 2007 and December 2013...
2018: BioMed Research International
Wojciech Ścierski, Grażyna Lisowska, Grzegorz Namysłowski, Maciej Misiołek, Jan Pilch, Elżbieta Menaszek, Radosław Gawlik, Marta Błażewicz
The aim of this study was to evaluate a novel composite material for tracheal reconstruction in an ovine model. A polymer containing various forms of carbon fibers (roving, woven, and nonwoven fabric) impregnated with polysulfone (PSU) was used to create cylindrical tracheal implants, 3 cm in length and 2.5 cm in diameter. Each implant, reinforced with five rings made of PSU-impregnated carbon-fiber roving, had three external layers made of carbon-fiber woven fabric and the inner layer formed of carbon-fiber nonwoven fabric...
2018: BioMed Research International
Xiaoxia Jiang, Xin Xu, Mengjie Wu, Zhonghai Guan, Xingyun Su, Shitu Chen, Haiyong Wang, Lisong Teng
Aberrant expression of G protein-coupled receptors (GPCRs) is frequently associated with tumorigenesis. G Protein-coupled receptor class C group 5 member A (GPRC5A) is a member of the GPCR superfamily, is expressed preferentially in lung tissues, and is regulated by various entities at multiple levels. GPRC5A exerts a tumor suppressive role in lung cancer and GPRC5A deletion promotes lung tumor initiation and progression. Recent advances have highlighted that GPRC5A dysregulation is found in various human cancers and is related to many tumor-associated signaling pathways, including the cyclic adenosine monophosphate (cAMP), nuclear factor (NF)- κ B, signal transducer and activator of transcription (STAT) 3, and focal adhesion kinase (FAK)/Src signaling...
2018: BioMed Research International
Jia Ning Foong, Gayathri Thevi Selvarajah, Abdullah Rasedee, Heshu Sulaiman Rahman, Chee Wun How, Chaw Yee Beh, Guan Young Teo, Chi Ling Ku
Canine mammary gland tumor (CMT) is the most common tumor in intact female dog. Zerumbone (ZER) has promising anticancer properties, but plagued with poor water solubility, poor absorption, bioavailability, and delivery to target tissues. To solubilize, ZER was loaded into nanostructured lipid carrier (NLC) to produce ZER-loaded NLC (ZER-NLC). The objectives of this study were to determine the antiproliferative effect and the mode of cell death induced by ZER-NLC and ZER on a canine mammary gland tumor (CMT) adenocarcinoma primary cell line...
2018: BioMed Research International
Zhenzhen Zhu, Yang Zha, Weiqing Wang, Xiaowei Wang, Yali Gao, Wei Lv
Background: Inflammatory myofibroblastic tumor (IMT), as a mesenchymal tumor, is common in the lung and abdomen but rare in the paranasal sinus and nasopharynx. Objective: This study aimed to summarize the clinical characteristics of IMT in the paranasal sinus and nasopharynx and analyze the relationship between the treatment and the overall survival (OS). Method: The clinical features, treatment, and follow-up data of patients diagnosed with IMT of the paranasal sinus or nasopharynx from 2006 to 2017 were retrospectively analyzed, and the previous literature was reviewed...
2018: BioMed Research International
Maria De Santis, Berardo Di Matteo, Emanuele Chisari, Gilberto Cincinelli, Peter Angele, Christian Lattermann, Giuseppe Filardo, Nicolò Danilo Vitale, Carlo Selmi, Elizaveta Kon
Introduction: Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, subchondral damage, and bone remodelling, affecting most commonly weight-bearing joints, such as the knee and hip. The loss of cartilage leads to joint space narrowing, pain, and loss of function which could ultimately require total joint replacement. The Wnt/ β catenin pathway is involved in the pathophysiology of OA and has been proposed as a therapeutic target. Endogenous and pharmacological inhibitors of this pathway were recently investigated within innovative therapies including the use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs)...
2018: BioMed Research International
Hao-Lun Sun, Wei-Wei Li, Chi Zhu, Wang-Sheng Jin, Yu-Hui Liu, Fan Zeng, Yan-Jiang Wang, Xian-Le Bu
Purpose: Recent study shows that blood-derived amyloid-beta (A β ) can induce cerebral amyloidosis and is involved in the pathogenesis of Alzheimer's disease (AD). The vast majority of blood A β is generated from platelet. Whether blood A β levels are associated with the count of platelets remains unknown. Methods: 58 clinically diagnosed AD patients, 18 11 C-PIB-PET diagnosed AD patients, and 61 age- and gender-matched cognitively normal controls were included to analyze the correlation of plasma A β levels with platelet count...
2018: BioMed Research International
Nihaya Salameh, Naser Shraim, Nidal Jaradat
Introduction: Volatile oils (VOs) have been commonly used in cosmetics and food as fragrances, flavoring, and preservative agents or in alternative medicine for their therapeutic effects. This necessitates investigating those plants and their VOs. This study was conducted to investigate the chemical compositions of the VOs of Micromeria fruticosa serpyllifolia growing widely in three regions in Palestine (i.e., Hebron, Ramallah, and Nablus districts representing south, middle, and north of West Bank)...
2018: BioMed Research International
Xiaolong Ji, Yingbin Shen, Xudan Guo
Polysaccharides obtained from Gynostemma pentaphyllum (Thunb.) Makino have promising prospects in functional food and nutraceuticals due to its broad range of biological activities including antioxidant, immunomodulatory, antitumor, hepatoprotective, neuroprotective, and antifatigue activities. These beneficial biological activities are related to chemical composition and structure of the G. pentaphyllum polysaccharides. The molecular weight, monosaccharide composition, and chemical structures could be influenced by both different extraction/purification techniques employed to obtain polysaccharide enriched products...
2018: BioMed Research International
Bruna Sinjari, Gianmaria D'Addazio, Ilaria De Tullio, Tonino Traini, Sergio Caputi
Introduction: Peri-implant marginal bone loss (MBL) seems to be more pronounced in the first year of loading despite all the studies and changes implemented to reduce it. Among the different causes, the presence of a microgap makes the interface between fixture and abutment colonizable by bacteria, causing an inflammatory response and consequent bone resorption. To reduce this several local antiseptics like chlorhexidine digluconate (CHX) were used after surgical procedures. Aim: The objective was to radiologically compare the MBL when a 0...
2018: BioMed Research International
Tomasz Kulczyk, Agata Czajka-Jakubowska, Agnieszka Przystańska
Objectives: Fractal analysis of the radiographic pattern of bone has been used to evaluate its quantitative properties. However, the relation between initial implant stability and quality of bone remains unclear. The objective of this study was to evaluate RFA values in relation to the fractal dimension of bone where the implant was inserted. Material and Methods: A total of 50 two-stage dental implants were placed in the maxilla and mandible of 32 patients. After implant placement, an implant stability quotient (ISQ) was measured in two perpendicular planes...
2018: BioMed Research International
Jing Sun, Yan Wang, Nianzhen Li, Hang Zhong, Hengyong Xu, Qing Zhu, Yiping Liu
The objective of the study is to compare the effects of free-range (FR) and cage-range (CR) breeding on gut microbiota and flavor compounds of Caoke (C) and Partridge Shank chickens (Q). A total of 120 experimental chickens were assigned to FR group and CR group; each group contain both 30 Caoke chickens and 30 Partridge Shank chickens. At 154 d old, 12 chickens of each group were selected and their cecal contents were extracted and examined for the composition of gut microbiota by illumina sequencing of the V3 region of the 16S rDNA genes, and flavor compounds were analyzed through headspace-solid-phase microextraction (HS-SPME) method...
2018: BioMed Research International
Sebastian P Boelch, Kilian Rueckl, Clara Fuchs, Martin Jordan, Markus Knauer, Andre Steinert, Maximilian Rudert, Martin Luedemann
Purpose: Copal® spacem is a new PMMA bone cement for fabricating spacers. This study compares elution of gentamicin, elution of vancomycin, and compressive strength of Copal® spacem and of Palacos® R+G at different vancomycin loadings in the powder of the cements. We hypothesized that antibiotic elution of Copal® spacem is superior at comparable compressive strength. Methods: Compression test specimens were fabricated using Copal® spacem manually loaded with 0...
2018: BioMed Research International
Abdel-Tawab H Mossa, Samia M M Mohafrash, Natarajan Chandrasekaran
Long-term application and extensive use of synthetic insecticides have resulted in accumulating their residues in food, milk, water, and soil and cause adverse health effects to human and ecosystems. Therefore, application of natural insecticides in agriculture and public health sectors has been increased as alternative to synthetic insecticides. The question here is, are all natural insecticides safe. Therefore, the review presented here focuses on the safety of natural insecticides. Natural insecticides contain chemical, mineral, and biological materials and some products are available commercially, e...
2018: BioMed Research International
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