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BioMed Research International

Natalia Niedziela, Krystyna Pierzchała, Jolanta Zalejska-Fiolka, Jacek T Niedziela, Ewa Romuk, Magdalena Torbus-Paluszczak, Monika Adamczyk-Sowa
Background: In addition to the widely known effect of vitamin D3 (vitD3 ) on the skeleton, its role in the regulation of the immune response was also confirmed. Aim: The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D3 . Methods: The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D3 deficiency (VitDd), insufficiency (VitDi), and normal vitamin D3 level (VitDn) subgroups...
2018: BioMed Research International
Lili Niu, KeYu Shi, Jing-Jing Xie, Sen Liu, Tao Zhong
The recent geographic expansion of wild boars and the even more recent development of numerous domestic pigs have spurred exploration on pig domestic origins. The porcine KIT gene has been showed to affect pleiotropic effects, blood parameters, and coat colour phenotypes, especially the white colour phenotype formation in European commercial breeds. Here, we described the use of SNPs to identify different selection patterns on the porcine KIT gene and the phylogenetic relationships of the inferred haplotypes...
2018: BioMed Research International
Wei Song, Junjun Wu, Longjiang Yu, Zhihong Peng
Phillygenin is a bioactive intergradient in Osmanthus fragrans, a well-known food additive and Chinese traditional medicine. This study was to investigate the hepatoprotective effects and pharmacokinetics of phillygenin. The hepatoprotective effect of phillygenin was assessed in carbon tetrachloride- (CCl4 -) intoxicated mice by monitoring levels of serum and tissue biomarkers. The pharmacokinetics of phillygenin was evaluated in the mouse after oral ( po , 24 mg / kg) or intravenous ( iv , 12 mg/kg) administration...
2018: BioMed Research International
Homayoun Sadeghi-Bazargani, Bahram Samadirad, Hojjat Hosseinpour-Feizi
Background: The aim of this study was to determine some epidemiological aspects of motorcycle user traffic fatalities including the crash mechanisms and injury patterns in East Azerbaijan, Iran (2006-2016). Methods: A total of 1840 motorcycle user mortal cases registered in East Azerbaijan forensic medicine database, in Iran, were analyzed over the time period between March 2006 and March 2016. The distribution and associations of both victim- and crash-related variables such as crash mechanism, types of involved vehicles, types of injuries, and demographic characteristics were investigated...
2018: BioMed Research International
Hongming Ji, Changchen Hu, Gangli Zhang, Jinrui Ren, Yihu Tan, Wenxiao Sun, Junwen Wang, Jun Li, Hongchao Liu, Ruifan Xie, Zhipeng Hao, Dongsheng Guo
[This corrects the article DOI: 10.1155/2015/183821.].
2018: BioMed Research International
Xiaoya Wang, Qin Yu, Hongmei Yue, Jiabin Zhang, Shuang Zeng, Fenfen Cui
[This corrects the article DOI: 10.1155/2016/9782031.].
2018: BioMed Research International
Fuyu Kobirumaki-Shimozawa, Togo Shimozawa, Kotaro Oyama, Yasuharu Kushida, Takako Terui, Shin'ichi Ishiwata, Norio Fukuda
The present study was conducted to systematically investigate the optimal viral titer as well as the volume of the adenovirus vector (ADV) that expresses α -actinin-AcGFP in the Z-disks of myocytes in the left ventricle (LV) of mice. An injection of 10  μ L ADV at viral titers of 2 to 4 × 1011 viral particles per mL (VP/mL) into the LV epicardial surface consistently expressed α -actinin-AcGFP in myocytes in vivo , with the fraction of AcGFP-expressing myocytes at ~10%. Our analysis revealed that SL was ~1...
2018: BioMed Research International
Le-Yu Lin, Lian-Wei Yang, Yuan-Yuan Shang, Yi-Hui Li, Ming Zhong, Wei Zhang, Hui Zhu
Objective: This study investigated the characteristics of carotid atherosclerosis in patients with atrial fibrillation (AF) and determined the feasibility and significance of the CHADS2 score in predicting the degree of carotid atherosclerosis. Methods: Consecutive patients (n = 109) with nonvalvular AF were registered and classified into two groups, the paroxysmal AF group (n = 59) and persistent AF group (n = 50). Fifty healthy patients, matched by sex and age, were considered the control group...
2018: BioMed Research International
Rodolfo Mauceri, Vera Panzarella, Laura Maniscalco, Alberto Bedogni, Maria Ester Licata, Antonino Albanese, Francesca Toia, Enzo Maria Giuseppe Cumbo, Giuseppina Mazzola, Olga Di Fede, Giuseppina Campisi
Introduction: The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods: We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer...
2018: BioMed Research International
Dominika Stygar, Wojciech Pigłowski, Elżbieta Chełmecka, Bronisława Skrzep-Poloczek, Tomasz Sawczyn, Wojciech Garłowski, Jerzy Jochem, Konrad Wojciech Karcz
Purpose: To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods: A high-fat diet (HF) was given to 28 rats and 28 more were fed with a control diet (CD) for 2 months. After that, half of each group underwent either DJOS or SHAM surgery. For the next 2 months, half of the animals in each operation group were kept on the same diet as before and half of them had the diet changed...
2018: BioMed Research International
Yao Yao, Liang Qiao, Kai Song, Xingquan Xu, Dongquan Shi, Zhihong Xu, Jin Dai, Jianghui Qin, Dongyang Chen, Qing Jiang
Purpose: The purpose of this retrospective study was to determine the association between preoperative soleal vein (SV) diameter and deep vein thrombosis (DVT) following total joint arthroplasty (TJA). Methods: A total of 402 patients were enrolled, with 229 patients undergoing total knee arthroplasty (TKA) and 173 patients undergoing total hip arthroplasty (THA). Ultrasonography was performed 1-3 days preoperatively, on postoperative days 1, 3, and 7, or before discharge and during follow-up...
2018: BioMed Research International
Du Kong, Wei Wang, Gang Du, Binyao Shi, Zhengchen Jiang, Bin Jin
Background: Although liver retraction using n-butyl-2-cyanoacrylate (NBCA) glue has been applied to laparoscopic upper abdominal surgery in noncirrhotic patients, there is still no consensus on its safety and feasibility for cirrhotic patients. In this study, we aimed to investigate the safety and effectiveness of liver retraction using NBCA glue during laparoscopic splenectomy and azygoportal disconnection (LSD) for gastroesophageal varices and hypersplenism secondary to liver cirrhosis and portal hypertension...
2018: BioMed Research International
Yaping Jing, Anping Li, Zhirong Liu, Pingrong Yang, Junshu Wei, Xinjun Chen, Tang Zhao, Yanrui Bai, Lajia Zha, Chunjiang Zhang
Objectives: Inflammatory Bowel Disease (IBD) is an autoimmune disease, and the gut microbiota has become a new therapeutic target. Herbal medicine (HM) has shown good efficacy in the clinical treatment of IBD; however, the synergistic actions of the dominant chemicals in HM decoctions are unclear. Methods: In this study, we explored whether the complicated interconnections between HM and the gut microbiota could allow crosstalk between HM ingredients. Saponins and polysaccharides, i...
2018: BioMed Research International
Gyu-Un Jung, Ji-Young Han, Kyung-Gyun Hwang, Chang-Joo Park, Panagiota G Stathopoulou, Joseph P Fiorellini
Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory diseases and periodontitis is known to be more common and more severe in patients with RA. Based on a paucity of studies about the relationship between common conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and periodontitis, this prospective study aimed to evaluate the adjunctive effect of csDMARDs on response to nonsurgical periodontal treatment in patients with RA. Thirty-two patients with RA (RA group) and 32 systemically healthy patients (control group) with periodontitis were included in this study...
2018: BioMed Research International
R Lo Giudice, G Rizzo, A Centofanti, A Favaloro, D Rizzo, G Cervino, R Squeri, B G Costa, V La Fauci, G Lo Giudice
Introduction: The use of equine bone blocks is widely reported for bone augmentation techniques. The block must be shaped according to the form of the defect that should be regenerated. The shaping could be performed by hand before or during the surgery, in a sterile ambient, or using a CNC milling machine that could not be sterile. The aim of our study was to evaluate if a steam sterilization could provide a medical grade sterilization of the blocks and to evaluate if bone microstructure and collagen structures change after different steam sterilization protocols provided by mainstream autoclave...
2018: BioMed Research International
Zhaoyan Li, Qingyu Wang, Gaoyang Chen, Xin Li, Qiwei Yang, Zhenwu Du, Ming Ren, Yang Song, Guizhen Zhang
Osteoarthritis (OA) is one of the most common diseases worldwide, but the pathogenic genes and pathways are largely unclear. The aim of this study was to screen and verify hub genes involved in OA and explore potential molecular mechanisms. The expression profiles of GSE12021 and GSE55235 were downloaded from the Gene Expression Omnibus (GEO) database, which contained 39 samples, including 20 osteoarthritis synovial membranes and 19 matched normal synovial membranes. The raw data were integrated to obtain differentially expressed genes (DEGs) and were deeply analyzed by bioinformatics methods...
2018: BioMed Research International
Hans G Richter, Natalia Mendez, Lorena Abarzua-Catalan, Guillermo J Valenzuela, Maria Seron-Ferre, Claudia Torres-Farfan
In the capuchin monkey ( Cebus apella ), a new-world nonhuman primate, maternal exposure to constant light during last third of gestation induces precocious maturation of the fetal adrenal and increased plasma cortisol in the newborn. Here, we further explored the effects of this challenge on the developmental programming of adrenal function in newborn and infant capuchin monkeys. We measured (i) plasma dehydroepiandrosterone sulphate (DHAS) and cortisol response to ACTH in infants with suppressed endogenous ACTH, (ii) plasma DHAS and cortisol response to ACTH in vitro , and (iii) adrenal weight and expression level of key factors in steroid synthesis (StAR and 3 β -HSD)...
2018: BioMed Research International
Maria D Gaintantzopoulou, Eleftherios T Farmakis, George C Eliades
The aim of the study was to comparatively evaluate the fracture strength and mode of root canal treated teeth restored with resin composites with and without posts. The lingual cusps of root canal treated first upper premolars (n = 10/group) were removed down to cervical enamel and restored with the following: group A: glass-fiber post (Glassix) followed by a particulate-filled composite resin (PFC, G-aenial posterior, 3 × 2 mm layers); group B: glass-fiber reinforced composite bulk fill liner (EverX posterior, 4 mm layer) with the PFC (2 mm layer)...
2018: BioMed Research International
Damiano Caruso, Domenico De Santis, Flaminia Rivosecchi, Marta Zerunian, Nicola Panvini, Marta Montesano, Tommaso Biondi, Davide Bellini, Marco Rengo, Andrea Laghi
Purpose: To prospectively compare the performance of James and Boer formula in contrast media (CM) administration, in terms of image quality and parenchymal enhancement in obese patients undergoing CT of the abdomen. Materials and Methods: Fifty-five patients with a body mass index (BMI) greater than 35 kg/m2 were prospectively included in the study. All patients underwent 64-row CT examination and were randomly divided in two groups: 26 patients in Group A and 29 patients in Group B...
2018: BioMed Research International
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