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BioMed Research International

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https://www.readbyqxmd.com/read/28642881/combining-carcinoembryonic-antigen-and-platelet-to-lymphocyte-ratio-to-predict-brain-metastasis-of-resected-lung-adenocarcinoma-patients
#1
Wei Wang, Chao Bian, Di Xia, Jin-Xi He, Ping Hai, Ren Zhao, Yan-Yang Wang
We aimed to evaluate the role of pretreatment carcinoembryonic antigen (CEA) and platelet to lymphocyte ratio (PLR) in predicting brain metastasis after radical surgery for lung adenocarcinoma patients. The records of 103 patients with completely resected lung adenocarcinoma between 2013 and 2014 were reviewed. Clinicopathologic characteristics of these patients were assessed in the Cox proportional hazards regression model. Brain metastasis occurred in 12 patients (11.6%). On univariate analysis, N2 stage (P = 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642880/longitudinal-patterns-of-stability-and-change-in-tenacious-goal-pursuit-and-flexible-goal-adjustment-among-older-people-over-a-9-year-period
#2
Guillaume Martinent, Nathalie Bailly, Claude Ferrand, Kamel Gana, Caroline Giraudeau, Michèle Joulain
Using the dual-process model of assimilative-tenacity (TGP) and accommodative-flexibility (FGA), the study aims to identify trajectories of TGP and FGA over five time points within a 9-year period, explore the relationships between the trajectories of TGP and FGA, and explore if participants from distinct TGP and FGA trajectories differed in indicators of well-being and depression. Latent class growth analysis was used in a five-wave longitudinal design among an older population of 747 participants over 65 years...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642879/aortic-arch-calcification-as-a-predictor-of-repeated-arteriovenous-fistula-failure-within-1-year-in-hemodialysis-patients
#3
Yit-Sheung Yap, Kai-Ting Ting, Wen-Che Chi, Cheng-Hao Lin, Yi-Chun Liu, Po-Lin Kuo, Wan-Long Chuang
OBJECTIVES: The aim of the study was to identify the factors associated with repeated arteriovenous fistula (AVF) failure within 1-year, especially the impact of aortic arch calcification (AAC) on patency of AVF. MATERIALS AND METHODS: We retrospectively assessed chest radiography in hemodialysis patients who had undergone initial AVF. The extent of AAC was categorized into four grades (0-3). The association between AAC grade, other clinical variables, and repeated failure of AVF was then analyzed by binary logistic regression analysis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642878/the-complexity-of-zoonotic-filariasis-episystem-and-its-consequences-a-multidisciplinary-view
#4
REVIEW
Fernando Simón, Javier González-Miguel, Alicia Diosdado, Paula Josefina Gómez, Rodrigo Morchón, Vladimir Kartashev
Vector-borne transmitted helminthic zoonosis affects the health and economy of both developing and developed countries. The concept of episystem includes the set of biological, environmental, and epidemiological elements of these diseases in defined geographic and temporal scales. Dirofilariasis caused by different species of the genus Dirofilaria is a disease affecting domestic and wild canines and felines and man, transmitted by different species of culicid mosquitoes. This complexity is increased because Dirofilaria species harbor intracellular symbiont Wolbachia bacteriae, which play a key role in the embryogenesis and development of dirofilariae and in the inflammatory pathology of the disease...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642877/the-effect-of-sodium-valproate-on-the-glioblastoma-u87-cell-line-tumor-development-on-the-chicken-embryo-chorioallantoic-membrane-and-on-ezh2-and-p53-expression
#5
Dovilė Kavaliauskaitė, Donatas Stakišaitis, Justė Martinkutė, Lina Šlekienė, Arūnas Kazlauskas, Ingrida Balnytė, Vaiva Lesauskaitė, Angelija Valančiūtė
Literature data support evidences that glioblastoma (GBM) patients experience prolonged survival due to sodium valproate (NaVP) treatment. The study assessed the human GBM cell U87 xenograft studied in the chicken embryo chorioallantoic membrane (CAM) model evaluating NaVP effect on tumor. Three groups of tumors (each n = 10) were studied: nontreated, treated with 4 mM, and treated with 8 mM of NaVP. The majority of tumors without NaVP treatment during tumor growth destroyed the chorionic epithelium, invaded the mesenchyme, and induced angiogenesis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642876/magnetic-separation-methods-for-the-detection-of-mycobacterium-avium-subsp-paratuberculosis-in-various-types-of-matrices-a-review
#6
REVIEW
Marketa Husakova, Radka Dziedzinska, Iva Slana
The main reasons to improve the detection of Mycobacterium avium subsp. paratuberculosis (MAP) are animal health and monitoring of MAP entering the food chain via meat, milk, and/or dairy products. Different approaches can be used for the detection of MAP, but the use of magnetic separation especially in conjunction with PCR as an end-point detection method has risen in past years. However, the extraction of DNA which is a crucial step prior to PCR detection can be complicated due to the presence of inhibitory substances...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642875/rapid-elimination-of-blood-alcohol-using-erythrocytes-mathematical-modeling-and-in-vitro-study
#7
Yuliya G Alexandrovich, Elena A Kosenko, Elena I Sinauridze, Sergey I Obydennyi, Igor I Kireev, Fazoil I Ataullakhanov, Yuriy G Kaminsky
Erythrocytes (RBCs) loaded with alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALD) can metabolize plasma ethanol and acetaldehyde but with low efficiency. We investigated the rate-limiting factors in ethanol oxidation by these enzymes loaded into RBCs. Mathematical modeling and in vitro experiments on human RBCs loaded simultaneously with ADH and ALD (by hypoosmotic dialysis) were performed. The simulation showed that the rate of nicotinamide-adenine dinucleotide (NAD(+)) generation in RBC glycolysis, but not the activities of the loaded enzymes, is the rate-limiting step in external ethanol oxidation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642874/combination-treatment-with-ppar%C3%AE-ligand-and-its-specific-inhibitor-gw9662-downregulates-bis-and-14-3-3-gamma-inhibiting-stem-like-properties-in-glioblastoma-cells
#8
Chang-Nim Im
PPARγ is a nuclear receptor that regulates differentiation and proliferation and is highly expressed in many cancer cells. Its synthetic ligands, such as rosiglitazone and ciglitazone, and its inhibitor GW9662, were shown to induce cellular differentiation, inhibit proliferation, and lead to apoptosis. Glioblastoma is a common brain tumor with poor survival prospects. Recently, glioblastoma stem cells (GSCs) have been examined as a potential target for anticancer therapy; however, little is known about the combined effect of various agents on GSCs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642873/serum-amyloid-a-induces-a-vascular-smooth-muscle-cell-phenotype-switch-through-the-p38-mapk-signaling-pathway
#9
Xincai Zhang, Jinqin Chen, Shixun Wang
Atherosclerosis is an important pathological condition which is accompanied by a vascular smooth muscle cell (VSMC) phenotype switch toward a synthetic phenotype. As an acute-phase protein, Serum Amyloid A (SAA) is thought to have a close relationship to atherosclerosis development. However, no study has investigated the direct effect of SAA on the VSMC phenotype switch, as well as the underlying mechanisms. The purpose of our study was to explore the effect of SAA on the VSMC phenotype switch and the potential mechanisms involved...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642872/chronic-expanding-hematoma-in-the-extremities-a-clinical-problem-of-adhesion-to-the-surrounding-tissues
#10
Akio Sakamoto, Takeshi Okamoto, Shuichi Matsuda
Chronic expanding hematoma is characterized by continuous growth of a blood collection. We analyzed the clinical features of 7 patients with chronic expanding hematomas in the extremities, with an average age of 65.6 years. All lesions occurred in the lower extremities, with 4 seen in the thigh and 3 in the knee region. Six patients had subcutaneous hematomas, while 1 was deep-seated in the thigh. The magnetic resonance features of the lesion were compatible with those of a standard hematoma. A low signal intensity on T1- and T2-weighted imaging at the pseudocapsule was also characteristic...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642871/promoting-mental-health-in-italian-middle-and-high-school-a-pilot-study
#11
Franco Veltro, Valentina Ialenti, Manuel Alejandro Morales García, Emiliana Bonanni, Claudia Iannone, Marinella D'Innocenzo, Antonella Gigantesco
AIM: In Italy, a handbook has been developed based on the principles of cooperative learning, life skills, self-effectiveness, and problem-solving at high school level. Early studies have shown the handbook's effectiveness. It has been hypothesized that the revised handbook could be more effective in middle schools. METHOD: The study design is a "pre- and posttest" that compares the results obtained from 91 students of the high schools with those of the 38 students from middle schools...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642870/imaging-and-management-of-incidental-renal-lesions
#12
REVIEW
Silvio Mazziotti, Giuseppe Cicero, Tommaso D'Angelo, Maria Adele Marino, Carmela Visalli, Ignazio Salamone, Giorgio Ascenti, Alfredo Blandino
The increased use of imaging modalities in the last years has led to a greater incidence in depicting abdominal incidental lesions. In particular, "incidentalomas" of the kidney are discovered in asymptomatic patients or patients who suffer from diseases not directly related to the kidneys. The aim of this paper is to provide the radiologist with a useful guide to recognize and classify the main incidental renal findings with the purpose of establishing the correct management. First we describe the so-called "pseudotumors" which are important to recognize in order to avoid a misdiagnosis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28642869/detection-of-microrna-in-hepatic-cirrhosis-and-hepatocellular-carcinoma-in-hepatitis-c-genotype-4-in-egyptian-patients
#13
Hala M Demerdash, Hend M Hussien, Ehab Hassouna, Emad A Arida
BACKGROUND: In Egypt, the prevalence of chronic hepatitis C (CHC) infection is 13.8% of whole population and about 80% of the patients with hepatocellular carcinoma have underling hepatitis C. AIM: This study was designed to assess the diagnostic value of plasma miR-122 and miR-21 in patients with CHC, genotype-4, to detect fibrosis progression versus noninvasive indices and their diagnostic value in detection of early stages of hepatocellular carcinoma (HCC). METHODOLOGY: A prospective study that included 180 patients, divided into 3 groups: healthy controls (group I), CHC patients (group II), and hepatitis C patients with HCC (group III); all cases were subjected to thorough clinical, radiological, and laboratory investigations...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638836/detecting-the-candidate-gender-determinants-by-bioinformatic-prediction-of-mirnas-and-their-targets-from-transcriptome-sequences-of-the-male-and-female-flowers-in-salix-suchowensis
#14
Suyun Wei, Ning Ye, Tongming Yin
MicroRNAs (miRNAs) belong to a class of small, noncoding, and endogenous single-stranded RNAs that negatively regulate gene expression at the posttranscriptional level. Potential miRNAs can be identified based on sequence homology since miRNAs are highly conserved in plants. In this study, we aligned the expressed sequence tags derived from flower buds of male and female S. suchowensis to miRNAs in the miRBase, which enable us to identify 34 potential miRNAs from flower buds of the alternate sexes. Among them, 11 were from the female and 23 were from the male...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638835/quality-improvement-interventions-for-nutritional-assessment-among-pregnant-mothers-in-northeastern-uganda
#15
Jonathan Izudi, Calvin Epidu, Andrew Katawera, Adeodata Kekitiinwa
INTRODUCTION: Assessment of pregnant mothers for nutritional status is a neglected intervention. In Kaabong Hospital, nutritional status of pregnant mothers was not assessed during antenatal care (ANC) visits. A quality improvement (QI) project was initiated to increase nutritional assessment using midupper arm circumference (MUAC) among pregnant mothers during ANC visits from 0 to 90% between April and September 2015. METHOD: Baylor-Uganda formed ANC Work Improvement Team (WIT) that reviewed ANC register, identified gaps in quality of care, analyzed root causes using cause-effect diagram, developed solutions, and tested and implemented the solution using Plan-Do-Study-Act cycles...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638834/personalized-consent-flow-in-contemporary-data-sharing-for-medical-research-a-viewpoint
#16
Ester A Rake, Marleen M H J van Gelder, David C Grim, Barend Heeren, Lucien J L P G Engelen, Tom H van de Belt
BACKGROUND: Health data personally collected by individuals with wearable devices and smartphones is becoming an important data source for healthcare, but also for medical research. OBJECTIVE: To describe a new consent model that allows people to control their personally collected health data and determine to what extent they want to share these for research purposes. METHODS: We developed, in close collaboration with patients, researchers, healthcare professionals, privacy experts, and an accredited Medical Ethical Review Committee, an innovative concept called "personalized consent flow" within a research platform connected to a personal health record...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638833/isolation-and-abiotic-stress-resistance-analyses-of-a-catalase-gene-from-ipomoea-batatas-l-lam
#17
Bin Yong, Xiaoyan Wang, Pan Xu, Haiyan Zheng, Xueting Fei, Zixi Hong, Qinqin Ma, Yuzhi Miao, Xianghua Yuan, Yusong Jiang, Huanhuan Shao
As an indicator of the antioxidant capability of plants, catalase can detoxify reactive oxygen species (ROS) generated by environmental stresses. Sweet potato is one of the top six most important crops in the world. However, its catalases remain largely unknown. In this study, a catalase encoding gene, IbCAT2 (accession number: KY615708), was identified and cloned from sweet potato cv. Xushu 18. It contained a 1479 nucleotides' open reading frame (ORF). S-R-L, Q-K-L, and a putative calmodulin binding domain were located at the C-terminus of IbCAT2, which suggests that IbCAT2 could be a peroxisomal catalase...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638832/the-response-of-macro-and-micronutrient-nutrient-status-and-biochemical-processes-in-rats-fed-on-a-diet-with-selenium-enriched-defatted-rapeseed-and-or-vitamin-e-supplementation
#18
Michaela Rýdlová, Karolína Růnová, Jiřina Száková, Alena Fučíková, Anna Hakenová, Petr Mlejnek, Václav Zídek, Jana Tremlová, Oto Mestek, Antonín Kaňa, Jarmila Zídková, Magdalena Melčová, Klára Truhlářová, Pavel Tlustoš
The response of nutrient status and biochemical processes in (i) Wistar and (ii) spontaneously hypertensive (SHR) rats upon dietary intake of selenium- (Se-) enriched defatted rapeseed (DRS) and/or vitamin E fortification was examined to assess the health benefit of DRS in animal nutrition. Twenty-four individuals of each type of rat were used: The control group was fed with an untreated diet (Diet A). In Diets B and C, soybean meal was replaced with defatted DRS, which comprised 14% of the total diet. The selenized DRS application resulted in ~3-fold increase of Se content in the diet...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638831/corrigendum-to-differences-in-brain-metabolic-impairment-between-chronic-mild-moderate-tbi-patients-with-and-without-visible-brain-lesions-based-on-mri
#19
Keiichi Ito, Yoshitaka Asano, Yuka Ikegame, Jun Shinoda
[This corrects the article DOI: 10.1155/2016/3794029.].
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638830/abdominal-hernias-giant-colon-diverticulum-gist-intestinal-pneumatosis-colon-ischemia-cold-intussusception-gallstone-ileus-and-foreign-bodies-our-experience-and-literature-review-of-incidental-gastrointestinal-mdct-findings
#20
REVIEW
G Di Grezia, G Gatta, R Rella, D Donatello, G Falco, R Grassi, R Grassi
Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today's experience of several gastrointestinal acute conditions such as abdominal hernia, giant colon diverticulum, GIST, intestinal pneumatosis, colon ischemia, cold intussusception, gallstone ileus, and foreign bodies which can require medical and surgical intervention or clinical follow-up...
2017: BioMed Research International
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