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Biomedical Journal

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https://www.readbyqxmd.com/read/28043421/cysto-duodeno-colic-ligament-and-its-clinical-relevance
#1
Vishwajit Ravindra Deshmukh, Seema Singh, Ritu Sehgal
During a routine dissection class for the undergraduate students at All India Institute of Medical Sciences, New Delhi, a rare uncommon variation of the peritoneal ligament was found. Information regarding variation in such type of accessory peritoneal reflections is necessary for anatomists, surgeons, and radiologists. Normally there was no peritoneal reflection between gallbladder, duodenum and transverse colon, but in the present case report, it was present and termed as cysto-duodeno-colic ligament. Knowledge of such variation is necessary during gallbladder surgeries and liver transplantation surgeries...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28043420/two-additional-augmenting-screws-with-posterior-short-segment-instrumentation-without-fusion-for-unstable-thoracolumbar-burst-fracture-comparisons-with-transpedicular-grafting-techniques
#2
Yu-Chih Lin, Kuo-Fon Fan, Jen-Chung Liao
BACKGROUND: Transpedicular grafting techniques with posterior short-segment instrumentation have demonstrated to prevent high implant failure in unstable thoracolumbar burst fractures. We tested our hypothesis that short-segment instrumentation with two additional augmenting screws in the injured vertebra could provide stability and was similar to those of the transpedicular grafting technique. METHODS: Twenty patients belonged to group A; treated with short-segment pedicle screw fixation and reinforced by two augmenting screws at the fractured vertebra...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28043419/percutaneous-radiofrequency-ablation-of-tumor-feeding-artery-before-target-tumor-ablation-may-reduce-local-tumor-progression-in-hepatocellular-carcinoma
#3
Ya-Ting Cheng, Wen-Juei Jeng, Chen-Chun Lin, Wei-Ting Chen, I-Shyan Sheen, Chun-Yen Lin, Shi-Ming Lin
BACKGROUND: Local tumor progression (LTP) in early-stage hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains high. Tumor feeding artery ablation (FAA) before target tumor ablation was reported to reduce LTP in patients with HCC >3 cm. The aim of our study is to investigate whether FAA before target tumor ablation may reduce LTP in HCC <3 cm. METHODS: We retrospectively analysis the outcome of patients with HCC <3 cm undergoing FAA before target tumor ablation (N = 17) compared to direct RFA to target tumor alone (N = 35)...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28043418/the-effectiveness-of-patient-tailored-treatment-for-acute-organophosphate-poisoning
#4
Chih-Chuan Lin, Dong-Zong Hung, Hsien-Yi Chen, Kuang-Hung Hsu
BACKGROUND: To determine a new pralidoxime (PAM) treatment guideline based on the severity of acute organophosphate intoxication patients, APACHE II score, and dynamic changes in serum butyrylcholinesterase (BuChE) activity. METHODS: This is a randomization trial. All patients received supportive care measurements and atropinization. Each enrolled patient was treated with 2 gm PAM intravenously as the loading dose. The control group was treated according to the WHO's recommended PAM regimen, and the experimental group was treated according to their APACHE II scores and dynamic changes in BuChE activity...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28043417/in-silico-structure-analysis-and-epitope-prediction-of%C3%A2-e3-cr1-beta-protein-of-human-adenovirus-e%C3%A2-for%C3%A2-vaccine-design
#5
Noman Ibna Amin Patwary, Md Saiful Islam, Md Sohel, Ismot Ara, Mohd Omar Faruk Sikder, Shah Md Shahik
BACKGROUND: Human Adenoviruses are divided into 7 species of Human Adenovirus A to G based on DNA genome homology. The Human Adenovirus E (HAdVs-E) genome is a linear, double-stranded DNA containing 38 protein-coding genes. Wild-type adenoviruses type E, are linked to a number of slight illnesses. The most important part of HAdVs-E is E3 CR1-beta protein which controls the host immune response and viral attachment. METHOD: We use numerous bio-informatics and immuno-informatics implements comprising sequence and construction tools for construction of 3D model and epitope prediction for HAdVs-E...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28043416/antidiarrhoeal-investigation-of-apium-leptophyllum-pers-by-modulation-of-na-k-atpase-nitrous-oxide-and-intestinal-transit-in-rats
#6
Himanshu Bhusan Sahoo, Rakesh Sagar, Anjan Kumar, Amrita Bhaiji, Subrat Kumar Bhattamishra
BACKGROUND: Apium leptophyllum (Pers.) is an annual herb with traditional appreciation for various pharmacological properties; however, the scientific information on this herb is insufficient. The aim of the present investigation was undertaken to evaluate flavonoidal fraction of A. leptophyllum fruit (FFALF) against diarrhoea on albino rats. METHODS: The antidiarrhoeal study was conducted by castor oil induce diarrhoea, prostaglandin E2 (PGE2) induced enteropooling and intestinal transit by charcoal meal test...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28043415/pralidoxime-and-pesticide-poisoning-a-question-of-severity
#7
EDITORIAL
Emma Louise Walton
In this issue of the Biomedical Journal, we highlight new data supporting the use of pralidoxime in the treatment of cases of organophosphate poisoning, which also suggest that WHO treatment guidelines should be updated. We also learn about a modified surgical technique to repair severe spinal injuries, as well as new insight into the structure of human adenovirus that could inform vaccine development.
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884384/radiographic-outcome-of-necrotic-immature-teeth-treated-with-two-endodontic-techniques-a-retrospective-analysis
#8
COMMENT
Szu-Ju Chen, Li-Ping Chen
BACKGROUND: The endodontic treatment of teeth with immature root has always been a challenge. To achieve a better prognosis, regenerative endodontic treatment may become a treatment trend for teeth with apical periodontitis and immature roots. METHODS: Clinical and radiographic data were collected from 38 endodontic treated immature teeth (21 apexification and 17 regeneration). Measure the radiographic outcome by quantifying the apical lesion. RESULTS: There was no statistical difference between the two treatments regarding PAI scores at the 1-, 3-, 6-, and 12-month follow-up (p > 0...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884383/histomorphometric-study-of-basilar-artery-in-normal-and-suicide-persons
#9
Suresh Kumar Parmar, V Satya Prasad
BACKGROUND: Depression in association with cerebro-vascular risk factors and white matter lesions is increasingly referred to as 'vascular depression'. There are several brain areas known for playing a role in patho-physiology of depression which may lead to suicidal tendencies, are fed by basilar artery. Therefore, the arterial histoarchitecture was studied in the normal and suicide individuals to establish a relationship between the vascular structural changes and depression. METHODS: 40 post-mortem samples (both sexes) of basilar artery have been collected and were grouped into normal and suicide groups...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884382/profile-of-glycated-hemoglobin-antioxidant-vitamin-and-cytokine-levels-in-pulmonary-tuberculosis-patients-a-cross-sectional-study-at-pulmonary-diseases-center-semarang-city-indonesia
#10
Praba Ginandjar, Lintang Dian Saraswati, Bagoes Widjanarko
BACKGROUND: Uncontrolled blood glucose, which marked by high level of HbA1c, increases risk of pulmonary TB because of cellular immunity dysfunction. This study aimed to analyze profile of glycated hemoglobin, antioxidant vitamins status and cytokines levels in active pulmonary TB patients. METHODS: This was a cross sectional study, conducted at Pulmonary Diseases Center Semarang City, Indonesia. Study subject consisted of 62 pulmonary TB patients, diagnosed with positive acid fast bacilli and chest X-ray...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884381/elevated-adiponectin-but-varied-response-in-circulating-leptin-levels-to-falciparum-malaria-in-type-2-diabetics-and-non-diabetic-controls
#11
COMMENT
Samuel Acquah, Benjamin Ackon Eghan, Johnson Nyarko Boampong
BACKGROUND: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity. METHODS: Levels of leptin and adiponectin were measured in 100 type 2 diabetics and 100 age-matched controls before and during falciparum malaria in a 2-year prospective study. Also, waist circumference (WC), weight, height and hip circumference were measured. Body mass index (BMI) and waist-to-hip ratio (WHR) were computed...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884380/association-of-endothelial-dysfunction-and-cytotoxin-associated-gene-a-positive-helicobacter-pylori-in-patients-with-cardiac-syndrome-x
#12
COMMENT
Yousef Rasmi, Hadi Rouhrazi, Ebrahim Khayati-Shal, Alireza Shirpoor, Ehsan Saboory
BACKGROUND: Existence of coronary endothelial dysfunction has been demonstrated in patients with cardiac syndrome X (CSX). In addition, Helicobacter pylorus (H. pylori) has been associated with CSX. We aimed to assess the possible association of endothelial dysfunction and cytotoxin-associated gene A-positive H. pylori (CagA+) infection in CSX patients. METHODS: Fifty-six patients with CSX (23 male/33 female; age: 51.25 ± 8.86 years) who were anti-H. pylori IgG-positive [H...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884379/purinergic-signalling-in-autoimmunity-a-role-for-the-p2x7r-in-systemic-lupus-erythematosus
#13
REVIEW
Francesco Di Virgilio, Anna Lisa Giuliani
Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, we focus on evidence supporting a possible role of the P2X7R in the pathogenesis of systemic lupus erythematosus (SLE).
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884378/purinergic-signaling-in-schistosomal-infection
#14
REVIEW
Claudia Lucia Martins Silva
Human schistosomiasis is a chronic inflammatory disease caused by blood fluke worms belonging to the genus Schistosoma. Health metrics indicate that the disease is related to an elevated number of years lost-to-disability and years lost-to-life. Schistosomiasis is an intravascular disease that is related to a Th1 and Th2 immune response polarization, and the degree of polarization affects the outcome of the disease. The purinergic system is composed of adenosine and nucleotides acting as key messenger molecules...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884377/danger-signals-inflammasomes-and-the-intricate-intracellular-lives-of-chlamydiae
#15
REVIEW
Matthew A Pettengill, Ali Abdul-Sater, Robson Coutinho-Silva, David M Ojcius
Chlamydiae are obligate intracellular bacterial pathogens, and as such are sensitive to alterations in the cellular physiology of their hosts. Chlamydial infections often cause pathologic consequences due to prolonged localized inflammation. Considerable advances have been made in the last few years regarding our understanding of how two key inflammation-associated signaling pathways influence the biology of Chlamydia infections: inflammation regulating purinergic signaling pathways significantly impact intracellular chlamydial development, and inflammasome activation modulates both chlamydial growth and infection mediated pro-inflammatory cytokine production...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884376/purinergic-signaling-in-infection-and-autoimmune-disease
#16
EDITORIAL
Luiz Eduardo Baggio Savio, Robson Coutinho-Silva
Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites. Here we highlight the role of purinergic receptor activation in infection and autoimmune diseases. Purinergic signaling and inflammasomes modulate the host immune response against chlamydial infections. In addition, increasing evidence suggests that purinergic signaling contributes to Schistosomiasis morbidity, a neglected tropical disease caused by parasitic worms called schistosomes...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884375/the-inflammasome-friend-or-foe-in-chlamydia-infection
#17
EDITORIAL
Emma Louise Walton
In this issue of the Biomedical Journal, we take a look at the still somewhat perplexing role of the inflammasome in Chlamydia infection. We also highlight findings suggesting a link between structural changes to arteries in the brain and the onset of depression. Finally, we learn about some of the implications of co-morbidity between diabetes and infectious diseases.
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27793273/nasal-gouty-tophus-report-a-rare-case-presenting-as-a-nasal-hump-with-nasal-obstruction
#18
COMMENT
John Chung-Han Wu, Pang-Yun Chou, Chih-Hao Chen
Dorsal nasal gouty tophus are rare occurrences with limited documentation. Here we report a male patient who has a history of poorly controlled gouty arthritis. He had nasal obstruction with an enlarging mass over his left nasal ridge for the past three years. Image studies revealed a nasal bone defect underneath the nasal lesion. The firm mass was excised and confirmed to be of gouty origin. The nasal bone defect was repaired with a titanium mesh plate to prevent nasal depression. He has fully recovered with no more nasal obstruction or recurrence of nasal tophus...
August 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27793272/a-pilot-study-on-trichomonas-vaginalis-in-women-with-recurrent-urinary-tract-infections
#19
Po-Chih Chang, Yu-Chao Hsu, Ming-Li Hsieh, Shih-Tsung Huang, Hsin-Chieh Huang, Yu Chen
BACKGROUND: Trichomoniasis and recurrent urinary tract infections (UTIs) shared similar risk factors, age distribution and overlapping symptoms. The aim of this study was to determine the prevalence of Trichomonas vaginalis (TV) in women with recurrent UTIs, attending a urology clinic in a medical center, in order to inform screening and treatment policies. METHODS: Women with recurrent UTIs, defined as the presence of lower urinary tract symptoms (dysuria, frequency and urgency) and three positive urine cultures on voided urine specimens in the previous year, were enrolled prospectively from January 2013 to April 2014...
August 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27793271/non-imaging-assisted-insertion-of-un-cuffed-non-tunneled-internal-jugular-venous-catheters-for-hemodialysis-safety-and-utility-in-modern-day-world
#20
COMMENT
Manish Rathi, Venkata Siva Tez Pinnamaneni, Vinay Sakhuja
BACKGROUND: Absolute necessity in acute kidney injury (AKI) and ignorance in chronic kidney disease (CKD) make the use of un-cuffed, non-tunneled catheters an indispensable vascular access for hemodialysis. Although these catheters should be inserted under radiological guidance, it may not be feasible in certain circumstances. The aim of the present study was to evaluate safety and outcome of non-imaging assisted insertion of these catheters in internal jugular vein (IJV) for hemodialysis...
August 2016: Biomedical Journal
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