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JMIR Research Protocols

Marleen van den Berg, Marloes van Dijk, Julianne Byrne, Helen Campbell, Claire Berger, Anja Borgmann-Staudt, Gabriele Calaminus, Uta Dirksen, Jeanette F Winther, Sophie D Fossa, Desiree Grabow, Victoria L Grandage, Marry M van den Heuvel-Eibrink, Melanie Kaiser, Tomas Kepak, Leontien C Kremer, Jarmila Kruseova, Claudia E Kuehni, Cornelis B Lambalk, Flora E van Leeuwen, Alison Leiper, Dalit Modan-Moses, Vera Morsellino, Claudia Spix, Peter Kaatsch, Eline van Dulmen-den Broeder
BACKGROUND: Despite a significant number of studies on female fertility following childhood, adolescent, and young adult (CAYA) cancer, studies establishing precise (dose-related) estimates of treatment-related risks are still scarce. Previous studies have been underpowered, did not include detailed treatment information, or were based on self-report only without any hormonal assessments. More precise assessments of who is at risk for sub- or infertility are needed. OBJECTIVE: The objective of our study is to describe the design and methods of 2 studies on female fertility (a cohort study and a nested case-control study) among female survivors of CAYA cancer performed within the European PanCareLIFE project...
September 14, 2018: JMIR Research Protocols
Patrick Sylim, Fang Liu, Alvin Marcelo, Paul Fontelo
BACKGROUND: Drug counterfeiting is a global problem with significant risks to consumers and the general public. In the Philippines, 30% of inspected drug stores in 2003 were found with substandard/spurious/falsely-labeled/falsified/counterfeit drugs. The economic burden on the population drug expenditures and on governments is high. The Philippine Food and Drug Administration (FDA) encourages the public to check the certificates of product registration and report any instances of counterfeiting...
September 13, 2018: JMIR Research Protocols
Lisa McCann, Kathryn A McMillan, Christopher Hewitt
BACKGROUND: A diagnosis of cancer in young adulthood can pose many different and unique challenges for individuals. The provision of adequate and appropriate information as well as care and support for teenagers and young adults at the time of diagnosis is central to their health care experience going forward. Moreover, appropriate and accessible information provision is critical to ensure that young individuals with cancer feel equipped and empowered to make decisions about, and be involved in, their treatment and recovery throughout their experience; this is a concept known as prehabilitation...
September 12, 2018: JMIR Research Protocols
Kath M Bogie, Guo-Qiang Zhang, Steven K Roggenkamp, Ningzhou Zeng, Jacinta Seton, Shiqiang Tao, Arielle L Bloostein, Jiayang Sun
BACKGROUND: Pressure ulcers (PU) and deep tissue injuries (DTI), collectively known as pressure injuries are serious complications causing staggering costs and human suffering with over 200 reported risk factors from many domains. Primary pressure injury prevention seeks to prevent the first incidence, while secondary PU/DTI prevention aims to decrease chronic recurrence. Clinical practice guidelines (CPG) combine evidence-based practice and expert opinion to aid clinicians in the goal of achieving best practices for primary and secondary prevention...
September 6, 2018: JMIR Research Protocols
Ian G Beasley, Leon N Davies, Nicola S Logan
BACKGROUND: Hyperopia occurs due to insufficient ocular growth and a failure to emmetropize in childhood. In anisohyperopia, it is unclear why one eye may remain hyperopic while the fellow eye grows toward an emmetropic state. Animal studies have shown that manipulating peripheral defocus through optical means while simultaneously providing correct axial focus can either discourage or encourage axial eye growth to effectively treat myopia or hyperopia, respectively. Myopia progression and axial eye growth can be significantly reduced in children and adolescents through the use of multifocal contact lenses...
September 5, 2018: JMIR Research Protocols
Sujay Kakarmath, Sara Golas, Jennifer Felsted, Joseph Kvedar, Kamal Jethwani, Stephen Agboola
BACKGROUND: Big data solutions, particularly machine learning predictive algorithms, have demonstrated the ability to unlock value from data in real time in many settings outside of health care. Rapid growth in electronic medical record adoption and the shift from a volume-based to a value-based reimbursement structure in the US health care system has spurred investments in machine learning solutions. Machine learning methods can be used to build flexible, customized, and automated predictive models to optimize resource allocation and improve the efficiency and quality of health care...
September 4, 2018: JMIR Research Protocols
Lidia Delrieu, Olivia Pérol, Béatrice Fervers, Christine Friedenreich, Jeff Vallance, Olivia Febvey-Combes, David Pérol, Brice Canada, Eva Roitmann, Armelle Dufresne, Thomas Bachelot, Pierre-Etienne Heudel, Olivier Trédan, Marina Touillaud, Vincent Pialoux
BACKGROUND: About 5% of breast cancer cases are metastatic at diagnosis, and 20%-30% of localized breast cancer cases become secondarily metastatic. Patients frequently report many detrimental symptoms related to metastasis and treatments. The physical, biological, psychological, and clinical benefits of physical activity during treatment in patients with localized breast cancer have been demonstrated; however, limited literature exists regarding physical activity and physical activity behavior change in patients with metastatic breast cancer...
August 30, 2018: JMIR Research Protocols
John Alexander Chalmers, Ursula Margaret Sansom-Daly, Pandora Patterson, Geoffrey McCowage, Antoinette Anazodo
BACKGROUND: Adolescent and young adults with cancer are at increased risk of psychosocial difficulties relative to their healthy peers. Current models of inpatient face-to-face psychosocial care might limit the capacity for clinicians to provide timely and personalized assessment and intervention for this group. Telehealth offers a promising alternative toward increasing access to the provision of evidence-based psychosocial assessment and treatment for adolescent and young adults with cancer...
August 29, 2018: JMIR Research Protocols
Viraj V Patel, Zoë Ginsburg, Sarit A Golub, Keith J Horvath, Nataly Rios, Kenneth H Mayer, Ryung S Kim, Julia H Arnsten
BACKGROUND: Young black and Latinx, gay, bisexual, and other men who have sex with men (YBLGBM, aged 18-29 years) have among the highest rates of new HIV infections in the United States and are not consistently reached by existing prevention interventions. Preexposure prophylaxis (PrEP), an oral antiretroviral regimen taken daily by HIV-uninfected individuals to prevent HIV acquisition, is highly efficacious in reducing HIV acquisition and could help stop the HIV epidemic in YBLGBM. Use of social media (eg, Facebook, Twitter, online dating sites) is ubiquitous among young people, providing an efficient avenue to engage YBLGBM to facilitate PrEP adoption...
August 28, 2018: JMIR Research Protocols
S Michael Ansari, Nicola Lama, Nicolas Blanc, Marija Bosilkovska, Andrea Donelli, Patrick Picavet, Gizelle Baker, Christelle Haziza, Frank Lüdicke
BACKGROUND: Tobacco harm reduction, substituting less harmful tobacco products for combustible cigarettes, is a complementary approach for smokers who would otherwise continue to smoke. The Philip Morris International (PMI) Tobacco Heating System (THS) 2.2 is a novel tobacco product with the potential to reduce the risk of harm in smokers compared to continued smoking of combustible cigarettes. It heats tobacco electrically in a controlled manner, never allowing the temperature to exceed 350°C, thereby preventing the combustion process from taking place and producing substantially lower levels of toxicants while providing nicotine, taste, ritual, and a sensory experience that closely parallels combustible cigarettes...
August 24, 2018: JMIR Research Protocols
Emma Kwegyir-Afful, Jos Verbeek, Lydia Aziato, Joseph D Seffah, Kimmo Räsänen
BACKGROUND: Preterm birth (PTB) is a leading cause of infant morbidity and mortality worldwide. Every year, 20 million babies are born with low birthweight (LBW), about 96% of which occur in low-income countries. Despite the associated dangers, in about 40%-50% of PTB and LBW cases, the causes remain unexplained. Existing evidence is inconclusive as to whether occupational physical activities such as heavy lifting are implicated. African women bear the transport burden of accessing basic needs for their families...
August 23, 2018: JMIR Research Protocols
Goshi Nishimura, Hiromitsu Hatakeyama, Osamu Shiono, Masataka Taguri, Masanori Komatsu, Daisuke Sano, Naoko Sakuma, Kenichiro Yabuki, Yasuhiro Arai, Kunihiko Shibata, Yoshihiro Chiba, Teruhiko Tanabe, Nobuhiko Oridate
BACKGROUND: We confirmed the safety of postoperative bio-chemoradiotherapy using cetuximab and docetaxel in a small number of patients with cis-platinum-intolerant core high-risk head and neck cancer. OBJECTIVE: To assess treatment efficacy, we planned a phase 2 study of postoperative bio-chemoradiotherapy for patients with cis-platinum-intolerant core high-risk head and neck cancer and will compare the results to those of previously collected radiotherapy data...
August 23, 2018: JMIR Research Protocols
Marjolein Verbiest, Suaree Borrell, Sally Dalhousie, Ridvan Tupa'i-Firestone, Tevita Funaki, Deborah Goodwin, Jacqueline Grey, Akarere Henry, Emily Hughes, Gayle Humphrey, Yannan Jiang, Andrew Jull, Crystal Pekepo, Jodie Schumacher, Lisa Te Morenga, Megan Tunks, Mereaumate Vano, Robyn Whittaker, Cliona Ni Mhurchu
BACKGROUND: New Zealand urgently requires scalable, effective, behavior change programs to support healthy lifestyles that are tailored to the needs and lived contexts of Māori and Pasifika communities. OBJECTIVE: The primary objective of this study is to determine the effects of a co-designed, culturally tailored, lifestyle support mHealth tool (the OL@-OR@ mobile phone app and website) on key risk factors and behaviors associated with an increased risk of noncommunicable disease (diet, physical activity, smoking, and alcohol consumption) compared with a control condition...
August 22, 2018: JMIR Research Protocols
Claudia I Martínez-Alcalá, Alejandra Rosales-Lagarde, Esmeralda Hernández-Alonso, Roberto Melchor-Agustin, Erika E Rodriguez-Torres, Benjamín A Itzá-Ortiz
BACKGROUND: Cognitive impairment is considered one of the most feared chronic conditions among the older adult population since its incidence is approximately twice more frequent than that of dementia. In Mexico, no studies or reports of older adults using technology for cognitive interventions have been published, given that institutions usually frame cognitive stimulation tasks in paper and pencil (ie, in the traditional manner). OBJECTIVE: The objective of this study was to create and analyze the effect, viability, and impact of a mobile app for cognitive stimulation implemented among a group of elderly adults (over 60 years of age) from the state of Hidalgo in Mexico...
August 21, 2018: JMIR Research Protocols
Renuka S Bindraban, Marlou Lh van Beneden, Mark Hh Kramer, Wouter W van Solinge, Suzanne Im Neppelenbroek, Merel van Wijnen, Anita Griffioen-Keijzer, Muhammad Al-Dulaimy, Maarten J Ten Berg, Prabath Wb Nanayakkara
BACKGROUND: Appropriate use of diagnostic laboratory tests is challenging, and estimates of 20% for overutilization and 45% for underutilization have been reported. Introducing effective and sustainable solutions to stimulate optimal use of laboratory testing in clinical practice is a challenge. A recent pilot study from our group, focusing on increasing the awareness about appropriate laboratory testing with the aim of changing the mindset of health care workers, has shown promising results...
August 21, 2018: JMIR Research Protocols
Nicola Clare Newton, Cath Chapman, Tim Slade, Chloe Conroy, Louise Thornton, Katrina Elizabeth Champion, Lexine Stapinski, Ina Koning, Maree Teesson
BACKGROUND: Early initiation of alcohol and cannabis use markedly increases the risk of harms associated with use, including the development of substance use and mental health disorders. To interrupt this trajectory, effective prevention during the adolescent period is critical. Despite evidence showing that parents can play a critical role in delaying substance use initiation, the majority of prevention programs focus on adolescents only. Accordingly, the Climate Schools Plus (CSP) program was developed to address this gap...
August 17, 2018: JMIR Research Protocols
Jolie Haun, Margeaux Chavez, Wendy Hathaway, Nicole Antinori, Christine Melillo, Bridget A Cotner, Julie McMahon-Grenz, Brian Zilka, Shilpa Patel-Teague, William Messina, Kim Nazi
BACKGROUND: The Veterans Health Administration (VHA) is making system-wide efforts to increase integrated use of health information technology (HIT), including My HealtheVet (MHV), the Veterans Affairs (VA) electronic patient portal, Vet Link kiosks, telehealth, and mobile apps. Integrated use of HIT can increase individual and system efficiency, maximize resources, and enhance patient outcomes. Prior research indicates that provider endorsement and reinforcement are key determinants of patient adoption of HIT...
August 15, 2018: JMIR Research Protocols
Nikhil Chauhan, Janet Bukovcan, Eveline Boucher, David Cosgrove, Julien Edeline, Bonnie Hamilton, Laura Kulik, Fayaz Master, Riad Salem
BACKGROUND: Globally, hepatocellular carcinoma is the second most common cause of cancer deaths. It remains challenging to intensify cancer treatment without impairing liver function. OBJECTIVE: The objective of the TheraSphere in the Treatment of Patients with Unresectable Hepatocellular Carcinoma (STOP-HCC) study is to examine the hypothesis that transarterial radioembolization (TheraSphere yttrium-90 glass microspheres) combined with standard first-line treatment with sorafenib will improve outcomes over treatment with sorafenib alone in unresectable hepatocellular carcinoma...
August 15, 2018: JMIR Research Protocols
Nicholas Bott, Shefali Kumar, Caitlyn Krebs, Jordan M Glenn, Erica N Madero, Jessie L Juusola
BACKGROUND: A growing body of evidence supports the use of lifestyle interventions for preventing or delaying the onset of Alzheimer disease and other forms of dementia in at-risk individuals. The development of internet-delivered programs would increase the scalability and reach of these interventions, but requires validation to ensure similar effectiveness to brick-and-mortar options. OBJECTIVE: We describe the study design, recruitment process, and baseline participant characteristics of the sample in the Virtual Cognitive Health (VC Health) study...
August 13, 2018: JMIR Research Protocols
Reena Lasrado, Therése Bielsten, Mark Hann, Linda Davies, James Schumm, Siobhan Reilly, Caroline Swarbrick, John Keady, Ingrid Hellström
BACKGROUND: The increasing rate of dementia and high health and social care costs call for effective measures to improve public health and enhance the wellbeing of people living with dementia and their relational networks. Most postdiagnostic services focus on the condition and the person with dementia with limited attention to the caring spouse or partner. The key focus of the study is to develop a guide for couples where one partner has a diagnosis of dementia. This couple management guide is delivered in the form of an app, DemPower...
August 10, 2018: JMIR Research Protocols
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