journal
MENU ▼
Read by QxMD icon Read
search

F1000Prime Reports

journal
https://www.readbyqxmd.com/read/26171217/corrigendum-to-recent-advances-in-the-diagnosis-and-management-of-pre-eclampsia
#1
Kate E Duhig, Andrew H Shennan
No abstract text is available yet for this article.
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26171216/ethylene-receptors-in-plants-why-so-much-complexity
#2
REVIEW
Daniel R Gallie
Ethylene is a hormone involved in numerous aspects of growth, development, and responses to biotic and abiotic stresses in plants. Ethylene is perceived through its binding to endoplasmic reticulum-localized receptors that function as negative regulators of ethylene signaling in the absence of the hormone. In Arabidopsis thaliana, five structurally and functionally different ethylene receptors are present. These differ in their primary sequence, in the domains present, and in the type of kinase activity exhibited, which may suggest functional differences among the receptors...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097739/hematopoietic-transcription-factor-mutations-and-inherited-platelet-dysfunction
#3
REVIEW
Natthapol Songdej, A Koneti Rao
The molecular and genetic mechanisms in most patients with inherited platelet dysfunction are unknown. There is increasing evidence that mutations in hematopoietic transcription factors are major players in the pathogenesis of defective megakaryopoiesis and platelet dysfunction in patients with inherited platelet disorders. These hematopoietic transcription factors include RUNX1, FLI1, GATA-1, and GFI1B. Mutations involving these transcription factors affect diverse aspects of platelet production and function at the genetic and molecular levels, culminating in clinical manifestations of thrombocytopenia and platelet dysfunction...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097738/advancing-our-knowledge-of-the-complexity-and-management-of-intimate-partner-violence-and-co-occurring-mental-health-and-substance-abuse-problems-in-women
#4
REVIEW
Robin Mason, Janice Du Mont
Globally, intimate partner violence (IPV) is a pervasive and insidious human rights problem with significant adverse physical health outcomes for women. Intimate partner violence has also been closely associated with poor mental health and substance use problems. However, little is known about the relationship among these co-occurring problems and how to best intervene or manage them. Here, we present findings from recent systematic reviews and meta-analyses (where available) to highlight developments in understanding and managing the complex co-occurring problems of intimate partner violence and mental health and substance use in women...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097737/recent-advances-in-understanding-and-managing-cystic-fibrosis-transmembrane-conductance-regulator-dysfunction
#5
REVIEW
Uta Griesenbach, Eric W F W Alton
Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians and has been extensively studied for many decades. The cystic fibrosis transmembrane conductance regulator gene was identified in 1989. It encodes a complex protein which has numerous cellular functions. Our understanding of cystic fibrosis pathophysiology and genetics is constantly expanding and being refined, leading to improved management of the disease and increased life expectancy in affected individuals.
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097736/insomnia-and-sleep-apnea-in-midlife-women-prevalence-and-consequences-to-health-and-functioning
#6
REVIEW
Martica H Hall, Christopher E Kline, Sara Nowakowski
Sleep disturbance is common during the menopausal transition, with numerous downstream consequences to health and functioning, including reduced quality of life, impaired mental health, and increased physical health morbidity. Insomnia affects approximately 50% of midlife women and is characterized by nocturnal symptoms of difficulties initiating or maintaining sleep (or both) and daytime symptoms that impair occupational, social, or other components of functioning. In addition, approximately 20% of midlife women develop sleep-disordered breathing during the menopausal transition...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097735/advances-in-understanding-giardia-determinants-and-mechanisms-of-chronic-sequelae
#7
REVIEW
Luther A Bartelt, R Balfour Sartor
Giardia lamblia is a flagellated protozoan that is the most common cause of intestinal parasitic infection in children living in resource-limited settings. The pathogenicity of Giardia has been debated since the parasite was first identified, and clinical outcomes vary across studies. Among recent perplexing findings are diametrically opposed associations between Giardia and acute versus persistent diarrhea and a poorly understood potential for long-term sequelae, including impaired child growth and cognitive development...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097734/recent-treatment-advances-and-novel-therapeutic-approaches-in-epilepsy
#8
REVIEW
Enrique Serrano, Andres M Kanner
The purpose of this article is to review recent advances in the treatment of epilepsy. It includes five antiepileptic drugs that have been recently added to the pharmacologic armamentarium and surgical techniques that have been developed in the last few years. Finally, we review ongoing research that may have a potential role in future treatments of epilepsy.
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097733/management-of-tachycardia
#9
REVIEW
Rakesh Gopinathannair, Brian Olshansky
Tachycardia, conventionally, but arbitrarily, defined as an atrial and/or ventricular rate of >100 beats per minute, is encountered commonly and can be physiological or pathological in origin. Various adverse consequences from tachycardia have been recognized, and an important one is the association between persistent tachycardia and cardiomyopathy. In this article, we provide an up-to-date review on the etiology of tachycardia, management strategies, and the prognosis of patients presenting with tachycardia and cardiomyopathy...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097732/recent-advances-in-understanding-and-managing-rhabdomyosarcoma
#10
REVIEW
Susan M Hiniker, Sarah S Donaldson
Rhabdomyosarcoma is the most common childhood soft tissue sarcoma and the fourth most common pediatric solid tumor. For most patients, treatment consists of a multimodality approach, including chemotherapy, surgery, and/or radiotherapy. To guide treatment, patients with rhabdomyosarcoma are risk stratified based on a number of factors. These factors include clinical group, which depends largely on the extent of resection and nodal involvement, and stage, which takes into account tumor size, invasion, nodal involvement, and disease site...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097731/endogenous-opioids-opposing-stress-with-a-cost
#11
REVIEW
Rita J Valentino, Elisabeth Van Bockstaele
The stress response is characterized by the coordinated engagement of central and peripheral neural systems in response to life-threatening challenges. It has been conserved through evolution and is essential for survival. However, the frequent or continual elicitation of the stress response by repeated or chronic stress, respectively, results in the dysfunction of stress response circuits, ultimately leading to stress-related pathology. In an effort to best respond to stressors, yet at the same time maintain homeostasis and avoid dysfunction, stress response systems are finely balanced and co-regulated by neuromodulators that exert opposing effects...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097730/recent-advances-in-the-management-of-peritoneal-dialysis-patients
#12
REVIEW
Anjali B Saxena
Peritoneal dialysis is a form of kidney dialysis that is used to remove accumulated metabolic waste products and water in patients with end stage kidney disease. Long-term exposure to high concentrations of glucose and its by-products, both found in peritoneal dialysis fluid, has been implicated in contributing to peritoneal damage over time, in turn limiting long-term use of the technique. Newer peritoneal dialysis solutions have been developed in the hope of reducing the unfavorable effects of peritoneal dialysis solutions...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097729/the-search-for-novel-analgesics-targets-and-mechanisms
#13
REVIEW
Tony L Yaksh, Sarah A Woller, Roshni Ramachandran, Linda S Sorkin
The management of the pain state is of great therapeutic relevance to virtually every medical specialty. Failure to manage its expression has deleterious consequence to the well-being of the organism. An understanding of the complex biology of the mechanisms underlying the processing of nociceptive information provides an important pathway towards development of novel and robust therapeutics. Importantly, preclinical models have been of considerable use in determining the linkage between mechanism and the associated behaviorally defined pain state...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097728/recent-advances-in-understanding-and-managing-leiomyosarcomas
#14
REVIEW
Florence Duffaud, Isabelle Ray-Coquard, Sébastien Salas, Patricia Pautier
Leiomyosarcomas are malignant mesenchymal tumours that derive from the smooth muscle lineage. They are studied and frequently treated as if they are the same as other soft tissue sarcomas. Recent developments suggest that a different approach may be more appropriate. Their underlying genetic mechanisms remain unclear, and complex. Unbalanced karyotypic defects are the only shared features observed across different leiomyosarcoma subtypes. Unlike other soft tissue sarcomas, leiomyosarcomas are particularly sensitive to the combination of gemcitabine and docetaxel...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097727/non-celiac-gluten-hypersensitivity-what-is-all-the-fuss-about
#15
REVIEW
Steffen Husby, Joseph Murray
Non-celiac gluten sensitivity (NCGS) has been introduced recently as a potentially common disease on the basis of studies of patients with claimed reactivity to gluten but without the characteristics of celiac disease (CD). CD is characterized by antibody reactivity toward the autoantigen transglutaminase 2, characteristic histological abnormalities of the small intestine, and an almost obligatory genetic haplotype (HLA-DQ2 or DQ8). The diagnosis of NCGS is based largely on the clinical suspicion of hyper-reactivity to gluten and the absence of the characteristics of CD...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097726/advances-in-the-management-of-basal-cell-carcinoma
#16
REVIEW
Jesse M Lewin, John A Carucci
Basal cell carcinoma (BCC), a malignant neoplasm derived from non-keratinizing cells that originate in the basal layer of the epidermis, is the most common cancer in humans. Several factors such as anatomic location, histologic features, primary or recurrent tumors, and patient characteristics influence the choice of treatment modality for BCC. Mohs micrographic surgery (MMS) facilitates optimal margin control and conservation of normal tissue for the management of BCC; however, other treatment modalities may also be implemented in the correct clinical scenario...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097725/advances-in-the-understanding-and-management-of-heart-transplantation
#17
REVIEW
Dhssraj Singh, David O Taylor
Cardiac transplantation represents one of the great triumphs in modern medicine and remains the cornerstone in the treatment of advanced heart failure. In this review, we contextualize pivotal developments in our understanding and management of cardiac transplant immunology, histopathology, rejection surveillance, drug development and surgery. We also discuss current limitations in their application and the impact of the left ventricular assist devices in bridging this gap.
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097724/recent-advances-in-renal-transplantation-antibody-mediated-rejection-takes-center-stage
#18
REVIEW
Eric Pouliquen, Alice Koenig, Chien Chia Chen, Antoine Sicard, Maud Rabeyrin, Emmanuel Morelon, Valérie Dubois, Olivier Thaunat
Overlooked for decades, antibodies have taken center stage in renal transplantation and are now widely recognized as the first cause of allograft failure. Diagnosis of antibody-mediated rejection has considerably improved with identification of antibody-mediated lesions in graft biopsies and advances made in the detection of circulating donor-specific antibodies. Unfortunately, this progress has not yet translated into better outcomes for patients. Indeed, in the absence of a drug able to suppress antibody generation by plasma cells, available therapies can only slow down graft destruction...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097723/advances-in-the-prevention-of-alzheimer-s-disease
#19
REVIEW
Shireen Sindi, Francesca Mangialasche, Miia Kivipelto
Alzheimer's disease (AD), the leading cause of dementia, has reached epidemic proportions, with major social, medical and economical burdens. With no currently available curative treatments, both the World Health Organization and the G8 Dementia Summit recently identified dementia and AD prevention as a major public health priority. Dementia and AD have a wide range of risk factors (genetic, vascular/metabolic and lifestyle-related), which often co-occur and thus interact with each other. Previous intervention efforts aimed at preventing dementia and AD focused on the management of single risk factors, with relatively modest findings...
2015: F1000Prime Reports
https://www.readbyqxmd.com/read/26097722/from-darwin-s-origin-of-species-toward-a-theory-of-natural-history
#20
REVIEW
Ferdinando Boero
Darwin is the father of evolutionary theory because he identified evolutionary patterns and, with Natural Selection, he ascertained the exquisitely ecological ultimate processes that lead to evolution. The proximate processes of evolution he proposed, however, predated the discovery of genetics, the backbone of modern evolutionary theory. The later discovery of the laws of inheritance by Mendel and the rediscovery of Mendel in the early 20th century led to two reforms of Darwinism: Neo-Darwinism and the Modern Synthesis (and subsequent refinements)...
2015: F1000Prime Reports
journal
journal
47584
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"