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Ophthalmic Surgery, Lasers & Imaging Retina

Jorge Orellana-Rios, Sho Yokoyama, Julia M Agee, Nayanika Challa, K Bailey Freund, Lawrence A Yannuzzi, R Theodore Smith
BACKGROUND AND OBJECTIVE: To use quantitative fundus autofluorescence (qAF) to analyze different stages of non-neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: In this cohort study, 38 pseudophakic patients and 36 age-matched controls participated. We performed near-infrared, spectral-domain optical coherence tomography and qAF imaging on 31 pseudophakic eyes and controls of participants older than 60 years with non-neovascular AMD phenotypes using the Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany)...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Mohamed A Hamid, Mohamed Tarek Moustafa, Javier Càceres-Del-Carpio, Baruch D Kuppermann, M Cristina Kenney
BACKGROUND AND OBJECTIVE: To investigate the effects of antiangiogenic drugs on the transcription profile of acetylation genes in immortalized human retinal pigment epithelium cells (ARPE-19) in vitro. MATERIALS AND METHODS: This in vitro study evaluated the effect of antiangiogenic drugs on the expression of histone acetylation genes on immortalized ARPE-19 cell cultures. ARPE-19 cells were cultured, plated, and treated for 24 hours with aflibercept (Eylea; Regeneron, Tarrytown, NY), ranibizumab (Lucentis; Genentech, South San Francisco, CA), or bevacizumab (Avastin; Genentech, South San Francisco, CA) at one (1×) or two times (2×) the concentrations of the clinical intravitreal dose...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Sean W Tsao, Rami Gabriel, Kunal Thaker, Baruch D Kuppermann, M Cristina Kenney
BACKGROUND AND OBJECTIVE: To evaluate whether brimonidine can prevent cytotoxicity in human retinal pigment epithelial (RPE) and Müller (MIO) cells after exposure to amyloid-beta 1-42 (Aβ42). MATERIALS AND METHODS: An in vitro model of geographic atrophy (GA), which is an end-stage complication of age-related macular degeneration (AMD), simulated with the application of Aβ42 in cell culture. RPE and MIO cells were pretreated with brimonidine for 6 hours, then exposed to 10μM Aβ42 for 24 hours...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Xuejing Chen, Kendra A Klein, Chirag P Shah, Jeffery S Heier
BACKROUND AND OBJECTIVE: Patients with idiopathic epiretinal membranes (ERMs) and visual acuity of 20/40 or better are often monitored until vision or associated symptoms worsen to affect everyday living. This study looks at the rate of progression to surgery and the characteristics associated with progression. PATIENTS AND METHODS: This study was a retrospective, consecutive case series of patients with newly diagnosed idiopathic ERMs who were referred to the Retina Service at the Ophthalmic Consultants of Boston between January 2009 and May 2015 with 20/40 or better visual acuity...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Malvika Arya, Carl B Rebhun, A Yasin Alibhai, Xuejing Chen, Carlos Moreira-Neto, Caroline R Baumal, Elias Reichel, Andre J Witkin, Jay S Duker, SriniVas R Sadda, Nadia K Waheed
BACKGROUND AND OBJECTIVE: To assess variability in vessel density (VD) measurements across three optical coherence tomography angiography (OCTA) devices to identify a methodology that offers the least amount of variation in VD, and to assess the effect of averaging of multiple scans on VD variability. PATIENTS AND METHODS: Fifteen eyes of eight healthy individuals were imaged consecutively on three OCTA devices. Segmentations at the superficial, deep, and full retinal layers were generated...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Rishi P Singh
No abstract text is available yet for this article.
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Luisa Pierro, Alessandro Arrigo, Giuseppe Casalino, Elisabetta Miserocchi, Emanuela Aragona, Francesco Bandello
The authors report a case of a female patient affected by primary vitreoretinal lymphoma (PVRL) showing retinal involvement. In particular, multiple subretinal hyperreflective infiltrates were found on optical coherence tomography (OCT). These alterations appeared hyperautofluorescent on fundus autofluorescence images. Interestingly, they also appeared hyperreflective on OCT angiography images. This case report underlined the high utility of OCT-based methodologies in accurately detecting and describing PVRL features...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Grayson W Armstrong, Safa Rahmani, Seanna Grob, Yoshihiro Yonekawa
Occult globe rupture is a rare but potentially devastating result of eye trauma. The authors present a case of a woman who sustained blunt trauma to the right eye resulting in a peripapillary circumferential posterior globe rupture. Clinically, the eye maintained good vision and normal intraocular pressure with a clear media, though subretinal fluid and retinal hemorrhage were present overlying the scleral defect. Enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) revealed a sharp step-off of the sclera, choroid, and Bruch's membrane/retinal pigment epithelium, with overlying intact and contiguous inner retina, corresponding to a posterior globe rupture...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Vinod Kumar, Pradeep Kumar, Shayeri Roy, Srikanta Kumar Padhy
A 62-year-old male underwent pars plana vitrectomy for diabetic tractional retinal detachment. Multiple pars plana cysts varying from 2 to 0.5 disc diameter size were noted intraoperatively. These images highlight the utility of intraoperative widefield systems in combination with scleral depression for visualization of periphery of retina. The images also illustrate the details of cysts clearly along with their anatomical relation with ora serrata. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:e169-e170...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Parth Shah, Jill S Zaveri, Luis J Haddock
This manuscript reports a rare association of the development of acute macular neuroretinopathy (AMN) after administration of an influenza vaccination. A 42-year-old white female presented with a 2-week history of black spots and a paracentral scotoma in the right eye after receiving a seasonal influenza vaccination. Findings on multimodal imaging were classic for AMN, and these findings improved but did not fully resolve 4 weeks after initial presentation with observation alone. Although a febrile illness or the use of oral contraceptives is most commonly associated with the development of AMN, it is important for clinicians to also consider influenza vaccination as a possible etiology...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Ryan D Stultz, Felipe F Conti, Jaya B Kumar, Erica Kotabish, Andrew Schachat, Justis P Ehlers, Yogen Saunthararajah, Rishi P Singh
Beta-thalassemia (β-thalassemia) minor is characterized by a mutation in one of the two β-globin genes (HBB) that produce the β-globin chains in the hemoglobin molecule. Although other hemoglobinopathies have been frequently associated with retinal disease, there are limited reports of retinal pathology with β-thalassemia minor. We report two patients with β-thalassemia minor presenting with decreased vision, vitreous hemorrhage, and proliferative retinopathy. This case report highlights that patients with β-thalassemia minor may require routine ocular examinations for peripheral retinal pathology, and β-thalassemia minor should be considered in the differential diagnosis for proliferative retinopathy...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Ann Q Tran, Nicolas A Yannuzzi, Elie H Motulsky, Xiao Yi Zhou, Anat Galor, Sander R Dubovy, Philip J Rosenfeld, Byron L Lam
A 73-year-old woman with 2 weeks of progressive painless vision loss was found to have bilateral corneal edema, jaw claudication, and temporal headache. Multimodal imaging revealed an Amalric choroidal infarct in the left eye visualized by widefield indocyanine green angiography and swept-source optical coherence tomography angiography (SS-OCTA). Prompt intravenous corticosteroid treatment resulted in 20/20 vision, and giant cell arteritis (GCA) was confirmed by a temporal artery biopsy. The case underscores the use of widefield SS-OCTA as a non-invasive test to aid in the diagnosis of GCA, as well as bilateral cornea edema as a rare presentation of GCA...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Darius M Moshfeghi
A term healthy infant was noted to have cephalohematoma following normal spontaneous vaginal delivery (NSVD). At 9 days of age, the attending team performed wide-angle remote digital fundus imaging and the left eye was noted to have scattered multi-laminar hemorrhages. Magnetic resonance imaging was performed which revealed occipital infarct and subarachnoid hemorrhage. A diagnosis of neonatal Terson syndrome was made. The child remained asymptomatic and the fundus hemorrhages resolved without sequelae. This case represents the first documented instance of Terson syndrome following NSVD and may represent a possible etiology of the common newborn retinal hemorrhage...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Elizabeth J Rossin, Deborah K VanderVeen, Yoshihiro Yonekawa
A newborn with severe neonatal Marfan syndrome (NMS), characterized by aortic root dilation, mitral and tricuspid valve regurgitation, diaphragmatic eventration with respiratory distress, intestinal malrotation, and various skeletal abnormalities, developed bilateral pupillary block from luxated crystalline lenses. He underwent bilateral immediate sequential vitrectomy and lensectomy to prevent further episodes of pupillary block. Bilateral surgery was performed due to the extremely high anesthesia risk. NMS is a rare and severe form of the connective tissue disease that can present with numerous systemic and ocular findings...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Moena Dean, David Kirschen, Jean Pierre Hubschman, Bradley R Straatsma, David Sarraf, Anibal Francone
The authors present the multimodal imaging findings of an unusual case of bilateral acquired progressive myelination of the optic disc during a 10-year follow-up period in a hyperopic adolescent patient in the absence of an underlying ocular or systemic abnormality. Myelination of the left optic disc was noted at age 7 and of the right optic disc at age 13, but no other ocular or systemic abnormalities were identified. Cross-sectional optical coherence tomography (OCT) and en face OCT angiography confirmed the presence of myelination of the retinal nerve fiber layer and excluded other etiologic possibilities including an astrocytic hamartoma...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Andrew W Browne, Felipe F Conti, Peter K Kaiser, Rishi P Singh
This report describes the use of inverted internal limiting membrane (ILM) flap technique as a treatment option for traumatic macular holes (MHs) with severe macular pathology. An interventional case series of two patients who experienced blunt trauma is reported. One patient developed two adjacent MHs and the second patient a MH with focal tissue avulsion in the fovea. Each patient underwent pars plana vitrectomy with ILM flap creation and intraocular gas tamponade. The ILM flap technique was successfully used for closure of MHs in one patient with a traumatic double MH and another patient with MH with foveal tissue avulsion...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Xintong Jiang, Shaochong Zhang, Zhaotian Zhang, Xuezhi Zhou, Yantao Wei
BACKGROUND AND OBJECTIVE: To compare the surgical outcome of 27-gauge pars plana vitrectomy (PPV) with 25-gauge PPV and evaluate the efficacy of air tamponade for the treatment of myopic foveoschisis (MF). PATIENTS AND METHODS: Sixty eyes of 60 consecutive patients were recruited to undergo vitrectomy, internal limiting membrane (ILM) peeling, and air tamponade for treatment of MF. These eyes were divided into two groups: the 27-gauge group (n = 29) and the 25-gauge group (n = 31)...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Aditya Kelkar, Jai Kelkar, Akshay Kothari, Hetal Mehta, Sampada Chitale, Rajesh Fogla, Shreekant Kelkar
BACKGROUND AND OBJECTIVE: To compare the visual outcome and complications of two different sutureless scleral-fixated intraocular lens (IOL) implantation techniques, that is, intrascleral IOL fixation technique and modified Yamane's technique of scleral fixation of IOL. PATIENTS AND METHODS: Patients who underwent scleral fixation of IOL (SFIOL) from June 2015 to February 2017 with more than 6 months of follow-up were examined retrospectively. Improvement in visual acuity (VA), intraocular pressure (IOP) measurements, endothelial cell count, central macular thickness (CMT), and intraoperative/postoperative complications were compared at 6 months follow-up...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Abhilash Guduru, Mayss Al-Sheikh, Arushi Gupta, Hasnat Ali, Subhadra Jalali, Jay Chhablani
BACKGROUND AND OBJECTIVE: To characterize the choriocapillaris (CC) vasculature in patients with retinitis pigmentosa (RP) and healthy controls using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: The CC of patients with RP and controls was analyzed using OCTA. Areas of no-flow, termed flow voids (FVs), were denoted in both. Comparisons between groups were done using Wilcox tests and generalized estimating equations. RESULTS: Fifty-four patients were included...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Kunbei Lai, Lijun Zhou, Xiaojin Zhong, Chuangxin Huang, Yajun Gong, Fabao Xu, Li Ma, Guandi Chen, Lin Cheng, Lin Lu, Chenjin Jin
BACKGROUND AND OBJECTIVE: To investigate the morphological difference of choroidal vasculature between polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) on optical coherence tomography (OCT). PATIENTS AND METHODS: One hundred eighty-nine patients with macula-involved PCV (n = 107) or nAMD (n = 82) were retrospectively reviewed. The subfoveal choroidal thickness (SFCT) and thickness of the Haller's layer were determined on enhanced depth imaging optical coherence tomography (EDI-OCT)...
October 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
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