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Brain Sciences

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https://www.readbyqxmd.com/read/28805746/melanocortins-melanocortin-receptors-and-multiple-sclerosis
#1
REVIEW
Robert P Lisak, Joyce A Benjamins
The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis. This review discusses corticosteroid dependent and independent effects of melanocortins on the peripheral immune system, central nervous system (CNS) effects mediated through neuronal regulation of immune system function, and direct effects on endogenous cells in the CNS. We have focused on the expression and function of melanocortin receptors in oligodendroglia (OL), the myelin producing cells of the CNS, with the goal of identifying new therapeutic approaches to decrease CNS damage in multiple sclerosis as well as to promote repair...
August 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28805718/myoclonic-disorders
#2
REVIEW
Olaf Eberhardt, Helge Topka
Few movement disorders seem to make a straightforward approach to diagnosis and treatment more difficult and frustrating than myoclonus, due to its plethora of causes and its variable classifications. Nevertheless, in recent years, exciting advances have been made in the elucidation of the pathophysiology and genetic basis of many disorders presenting with myoclonus. Here, we provide a review of all of the important types of myoclonus encountered in pediatric and adult neurology, with an emphasis on the recent developments that have led to a deeper understanding of this intriguing phenomenon...
August 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28805695/infants-investigated-by-the-child-welfare-system-exploring-a-distinct-profile-of-risks-service-needs-and-referrals-for-support-in-ontario
#3
Joanne Filippelli, Barbara Fallon, Esme Fuller-Thomson, Nico Trocmé
The science of early childhood development underscores that maltreatment and other adversities experienced during infancy heightens the risk for poor developmental and socio-emotional outcomes. Referrals to supportive services by the child welfare system are particularly critical during infancy given the rapidity of brain development and infants' sensitivity to their environment. The main objectives of the current study are to: (1) examine age-specific differences in clinical and case characteristics; (2) determine the factors associated with the service referral decision involving infants; and (3) explore the types of services families have been referred to at the conclusion of a maltreatment-related investigation...
August 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28805691/structural-and-neuronal-integrity-measures-of-fatigue-severity-in-multiple-sclerosis
#4
Evanthia Bernitsas, Kalyan Yarraguntla, Fen Bao, Rishi Sood, Carla Santiago-Martinez, Rajkumar Govindan, Omar Khan, Navid Seraji-Bozorgzad
Fatigue is a common and disabling symptom in Multiple Sclerosis (MS). However, consistent neuroimaging correlates of its severity are not fully elucidated. In this article, we study the neuronal correlates of fatigue severity in MS. Forty-three Relapsing Remitting MS (RRMS) patients with MS-related fatigue (Fatigue Severity Scale (FSS) range: 1-7) and Expanded Disability Status Scale (EDSS) ≤ 4, were divided into high fatigue (HF, FSS ≥ 5.1) and low fatigue groups (LF, FSS ≤ 3). We measured T2 lesion load using a semi-automated technique...
August 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28800081/autonomic-dysfunction-after-mild-traumatic-brain-injury
#5
Dmitry Esterov, Brian D Greenwald
A mild traumatic brain injury (mTBI) is a complex pathophysiologic process that has a systemic effect on the body aside from solely an impairment in cognitive function. Dysfunction of the autonomic nervous system (ANS) has been found to induce abnormalities in organ systems throughout the body, and may contribute to cardiovascular dysregulation and increased mortality. Autonomic dysfunction, also known as dysautonomia, has been studied in moderate and severe TBI, and has emerged as a major contributing factor in the symptomatology in mTBI as well...
August 11, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28792451/a-novel-computer-oculomotor-rehabilitation-cor-program-for-mild-traumatic-brain-injury-mtbi
#6
Kenneth J Ciuffreda, Naveen K Yadav, Preethi Thiagarajan, Diana P Ludlam
Individuals with traumatic brain injury (TBI) manifest a wide range of visual dysfunctions. One of the most prevalent involves the oculomotor system, which includes version, vergence, and accommodation. However, until recently, there has been no comprehensive, computer-based program for remediation of these oculomotor deficits. We present such an oculomotor rehabilitation program that has been tested in a clinical trial in patients having TBI with a high degree of success based on before-and-after objective system recordings, performance measures, and related visual symptomotology...
August 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28792441/binasal-occlusion-bno-visual-motion-sensitivity-vms-and-the-visually-evoked-potential-vep-in-mild-traumatic-brain-injury-and-traumatic-brain-injury-mtbi-tbi
#7
REVIEW
Kenneth J Ciuffreda, Naveen K Yadav, Diana P Ludlam
The diagnosis and treatment of the possible visual sequelae in those with traumatic brain injury (TBI) represents an important area of health care in this special population. One of their most prevalent yet elusive visual symptoms is visual motion sensitivity (VMS). In this review, we present the basic VMS phenomenon and its related symptoms, clinical studies in the area, clinical research investigations using the visual-evoked potential (VEP) as a cortical probe, and possible mechanisms and related neurophysiology that may underlie VMS...
August 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28786918/mental-illness-in-children-childhood-illness-and-supporting-the-family
#8
EDITORIAL
Rosemary Sheehan
Childhood is a stage of life that is filled with potential for development, and the early years of childhood see immense physical changes in growth; mastery over body functions like movement; the acquisition of language and cognitive development to understand their own and others' thinking and reasoning; and the psychosocial development of trust in the world, comfort in the care they receive from parents and caregivers, and the sense of being secure in themselves that this engenders. [...].
August 8, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28783134/assessing-the-effectiveness-of-neurofeedback-training-in-the-context-of-clinical-and-social-neuroscience
#9
REVIEW
Franklin Orndorff-Plunkett, Fiza Singh, Oriana R Aragón, Jaime A Pineda
Social neuroscience benefits from the experimental manipulation of neuronal activity. One possible manipulation, neurofeedback, is an operant conditioning-based technique in which individuals sense, interact with, and manage their own physiological and mental states. Neurofeedback has been applied to a wide variety of psychiatric illnesses, as well as to treat sub-clinical symptoms, and even to enhance performance in healthy populations. Despite growing interest, there persists a level of distrust and/or bias in the medical and research communities in the USA toward neurofeedback and other functional interventions...
August 7, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28783098/brain-injury-and-severe-eating-difficulties-at-admission-patient-perspective-nine-to-fifteen-months-after-discharge-a-pilot-study
#10
Annette Kjaersgaard, Hanne Kaae Kristensen
The purpose of this pilot study was to explore and interpret the way that individuals with acquired brain injury, admitted to inpatient neurorehabilitation with severe eating difficulties, experienced eating nine to fifteen months after discharge. Four individuals with acquired brain injury were interviewed via qualitative semi-structured interviews. An explorative study was conducted to study eating difficulties. Qualitative content analysis was used. Four main themes emerged from the analysis: personal values related to eating, swallowing difficulties, eating and drinking, meals and social life...
August 7, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28788061/from-the-brain-to-the-field-the-applications-of-social-neuroscience-to-economics-health-and-law
#11
REVIEW
Gayannée Kedia, Lasana Harris, Gert-Jan Lelieveld, Lotte van Dillen
Social neuroscience aims to understand the biological systems that underlie people's thoughts, feelings and actions in light of the social context in which they operate. Over the past few decades, social neuroscience has captured the interest of scholars, practitioners, and experts in other disciplines, as well as the general public who more and more draw upon the insights and methods of social neuroscience to explain, predict and change behavior. With the popularity of the field growing, it has become increasingly important to consider the validity of social neuroscience findings as well as what questions it can and cannot address...
July 28, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28757598/selective-serotonin-reuptake-inhibitors-for-treating-neurocognitive-and-neuropsychiatric-disorders-following-traumatic-brain-injury-an-evaluation-of-current-evidence
#12
REVIEW
John K Yue, John F Burke, Pavan S Upadhyayula, Ethan A Winkler, Hansen Deng, Caitlin K Robinson, Romain Pirracchio, Catherine G Suen, Sourabh Sharma, Adam R Ferguson, Laura B Ngwenya, Murray B Stein, Geoffrey T Manley, Phiroz E Tarapore
The prevalence of neuropsychiatric disorders following traumatic brain injury (TBI) is 20%-50%, and disorders of mood and cognition may remain even after recovery of neurologic function is achieved. Selective serotonin reuptake inhibitors (SSRI) block the reuptake of serotonin in presynaptic cells to lead to increased serotonergic activity in the synaptic cleft, constituting first-line treatment for a variety of neurocognitive and neuropsychiatric disorders. This review investigates the utility of SSRIs in treating post-TBI disorders...
July 25, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28737691/coagulopathy-in-the-setting-of-mild-traumatic-brain-injury-truths-and-consequences
#13
REVIEW
Joseph P Herbert, Andrew R Guillotte, Richard D Hammer, N Scott Litofsky
Mild traumatic brain injury (mTBI) is a common, although poorly-defined clinical entity. Despite its initially mild presentation, patients with mTBI can rapidly deteriorate, often due to significant expansion of intracranial hemorrhage. TBI-associated coagulopathy is the topic of significant clinical and basic science research. Unlike trauma-induced coagulopathy (TIC), TBI-associated coagulopathy does not generally follow widespread injury or global hypoperfusion, suggesting a distinct pathogenesis. Although the fundamental mechanisms of TBI-associated coagulopathy are far from clearly elucidated, several candidate molecules (tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), tissue factor (TF), and brain-derived microparticles (BDMP)) have been proposed which might explain how even minor brain injury can induce local and systemic coagulopathy...
July 22, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28754001/using-machine-learning-to-discover-latent-social-phenotypes-in-free-ranging-macaques
#14
Seth Madlon-Kay, Lauren Brent, Michael Montague, Katherine Heller, Michael Platt
Investigating the biological bases of social phenotypes is challenging because social behavior is both high-dimensional and richly structured, and biological factors are more likely to influence complex patterns of behavior rather than any single behavior in isolation. The space of all possible patterns of interactions among behaviors is too large to investigate using conventional statistical methods. In order to quantitatively define social phenotypes from natural behavior, we developed a machine learning model to identify and measure patterns of behavior in naturalistic observational data, as well as their relationships to biological, environmental, and demographic sources of variation...
July 21, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28753986/brain-interaction-during-cooperation-evaluating-local-properties-of-multiple-brain-network
#15
Nicolina Sciaraffa, Gianluca Borghini, Pietro Aricò, Gianluca Di Flumeri, Alfredo Colosimo, Anastasios Bezerianos, Nitish V Thakor, Fabio Babiloni
Subjects' interaction is the core of most human activities. This is the reason why a lack of coordination is often the cause of missing goals, more than individual failure. While there are different subjective and objective measures to assess the level of mental effort required by subjects while facing a situation that is getting harder, that is, mental workload, to define an objective measure based on how and if team members are interacting is not so straightforward. In this study, behavioral, subjective and synchronized electroencephalographic data were collected from couples involved in a cooperative task to describe the relationship between task difficulty and team coordination, in the sense of interaction aimed at cooperatively performing the assignment...
July 21, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28753980/transgenerational-social-stress-alters-immune-behavior-associations-and-the-response-to-vaccination
#16
Alexandria Hicks-Nelson, Gillian Beamer, Kursat Gurel, Rachel Cooper, Benjamin C Nephew
Similar to the multi-hit theory of schizophrenia, social behavior pathologies are mediated by multiple factors across generations, likely acting additively, synergistically, or antagonistically. Exposure to social adversity, especially during early life, has been proposed to induce depression symptoms through immune mediated mechanisms. Basal immune factors are altered in a variety of neurobehavioral models. In the current study, we assessed two aspects of a transgenerational chronic social stress (CSS) rat model and its effects on the immune system...
July 21, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28726717/mini-review-of-controlled-cortical-impact-a-well-suited-device-for-concussion-research
#17
REVIEW
Nicole Osier, C Edward Dixon
Mild traumatic brain injury (mTBI) is increasingly recognized as a significant public health problem which warrants additional research. Part of the effort to understand mTBI and concussion includes modeling in animals. Controlled cortical impact (CCI) is a commonly employed and well-characterized model of experimental TBI that has been utilized for three decades. Today, several commercially available pneumatic- and electromagnetic-CCI devices exist as do a variety of standard and custom injury induction tips...
July 20, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28753911/morphological-and-molecular-basis-of-cytoplasmic-dilation-and-swelling-in-cortical-migrating-neurons
#18
REVIEW
Yoshiaki V Nishimura, Yo-Ichi Nabeshima, Takeshi Kawauchi
During corticogenesis, neuronal migration is an essential step for formation of a functional brain, and abnormal migration is known to cause various neurological disorders. Neuronal migration is not just a simple movement of the cell body, but a consequence of various morphological changes and coordinated subcellular events. Recent advances in in vivo and ex vivo cell biological approaches, such as in utero gene transfer, slice culture and ex vivo chemical inhibitor techniques, have revealed details of the morphological and molecular aspects of neuronal migration...
July 19, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28718840/bilinguals-working-memory-wm-advantage-and-their-dual-language-practices
#19
Eunju Yang
The present study investigates a possible working memory (WM) difference between monolingual and bilingual groups and explores the relationship between their WM advantage and language practices. A mixed methods design was employed for the study. To measure participants' WM, auditory and visual digit span tasks were conducted on the different language groups: 20 Korean near-monolinguals, and 40 Korean-English bilinguals with two different levels of second language (L2) proficiency. Bilinguals' daily language practices were explored through semi-structured interviews with eight bilinguals...
July 18, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28714935/sensory-and-physico-psychological-metaphor-comprehension-in-children-with-asd-a-preliminary-study-on-the-outcomes-of-a-treatment
#20
Sergio Melogno, Maria Antonietta Pinto, Gloria Di Filippo
Recent research into difficulties in figurative language in children with ASD highlighted that it is possible to devise training interventions to overcome these difficulties by teaching specific strategies. This study describes how children with ASD can improve their capability to explain metaphors with a treatment. Two types of metaphors, in the "X is Y" form, were addressed: sensory and physico-psychological. To face the difficulties posed by these metaphors, the adult taught two strategies: inserting the connective "is like" between "X" and "Y", which transforms the metaphor into a simile; comparing "X" and "Y" by means of thinking maps...
July 17, 2017: Brain Sciences
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