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Brain Sciences

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https://www.readbyqxmd.com/read/28934119/integrity-of-cerebellar-fastigial-nucleus-intrinsic-neurons-is-critical-for-the-global-ischemic-preconditioning
#1
Eugene V Golanov, Angelique S Regnier-Golanov, Gavin W Britz
Excitation of intrinsic neurons of cerebellar fastigial nucleus (FN) renders brain tolerant to local and global ischemia. This effect reaches a maximum 72 h after the stimulation and lasts over 10 days. Comparable neuroprotection is observed following sublethal global brain ischemia, a phenomenon known as preconditioning. We hypothesized that FN may participate in the mechanisms of ischemic preconditioning as a part of the intrinsic neuroprotective mechanism. To explore potential significance of FN neurons in brain ischemic tolerance we lesioned intrinsic FN neurons with excitotoxin ibotenic acid five days before exposure to 20 min four-vessel occlusion (4-VO) global ischemia while analyzing neuronal damage in Cornu Ammoni area 1 (CA1) hippocampal area one week later...
September 21, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28925955/investing-in-the-early-childhood-mental-health-workforce-development-enhancing-professionals-competencies-to-support-emotion-and-behavior-regulation-in-young-children
#2
Shulamit N Ritblatt, Audrey Hokoda, Charles Van Liew
This paper delineates a preventive approach to early childhood mental health by preparing the workforce to provide relational, sensitive care to young children ages 0-5. One of the most prevalent issues in early childhood is behavioral challenges and the inability of young children to regulate themselves. This leads to an expulsion rate in early childhood (3-4 times higher than K-12 expulsion rate) and future mental health issues. The Early Childhood Social-Emotional and Behavior Regulation Intervention Specialist (EC-SEBRIS) graduate level certificate program was created to strengthen early care and education providers with the knowledge and practice of how to support emotion and behavior regulation in young children in their groups...
September 19, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28926944/coach-cv-the-seven-clinical-phenotypes-of-concussion
#3
Neil Craton, Haitham Ali, Stephane Lenoski
Our understanding of the diverse physiological manifestations of concussion is changing rapidly. This has an influence on the clinical assessment of patients who have sustained a concussion. The 2017 Consensus Statement on Concussion in Sport states that numerous post-injury clinical findings, such as cognitive deficits, post-traumatic headaches, dizziness, difficulties with oculomotor function, and depression have all been associated with a poorer prognosis in concussed patients. This demonstrates that there are several potential clinical manifestations after head injury warranting clinical evaluation...
September 16, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28914767/feasibility-of-equivalent-dipole-models-for-electroencephalogram-based-brain-computer-interfaces
#4
Paul H Schimpf
This article examines the localization errors of equivalent dipolar sources inverted from the surface electroencephalogram in order to determine the feasibility of using their location as classification parameters for non-invasive brain computer interfaces. Inverse localization errors are examined for two head models: a model represented by four concentric spheres and a realistic model based on medical imagery. It is shown that the spherical model results in localization ambiguity such that a number of dipolar sources, with different azimuths and varying orientations, provide a near match to the electroencephalogram of the best equivalent source...
September 15, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28891972/erratum-balconi-m-et-al-evidences-from-rewarding-system-frn-and-p300-effect-in-internet-addiction-in-young-people-short-title-rewarding-system-and-eeg-in-internet-addiction-brain-sciences-2017-7-81
#5
Michela Balconi, Irene Venturella, Roberta Finocchiaro
We would like to submit the following erratum to our recently published paper [1] due to the error in the title.[...].
September 11, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28891971/risk-factors-for-mild-cognitive-impairment-mci
#6
EDITORIAL
Andrea Mary Loftus
It was has been my pleasure to have acted as the guest editor for the Brain Sciences Special Issue on Mild Cognitive Impairment (MCI).[...].
September 11, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28891930/vitamin-d-receptor-gene-polymorphisms-associated-with-childhood-autism
#7
Anna Cieślińska, Elżbieta Kostyra, Barbara Chwała, Małgorzata Moszyńska-Dumara, Ewa Fiedorowicz, Małgorzata Teodorowicz, Huub F J Savelkoul
BACKGROUND: Autism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined disorders whereby currently no biological markers are common to all affected individuals. A deregulated immune response may be contributing to the etiology of ASD. The active metabolite of vitamin D₃ has an immunoregulatory role mediated by binding to the vitamin D receptor (VDR) in monocyte, macrophages, and lymphocytes. The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene...
September 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28878193/time-frequency-analysis-of-mu-rhythm-activity-during-picture-and-video-action-naming-tasks
#8
Megan E Cuellar, Christina M Del Toro
This study used whole-head 64 channel electroencephalography to measure changes in sensorimotor activity-as indexed by the mu rhythm-in neurologically-healthy adults, during subvocal confrontation naming tasks. Independent component analyses revealed sensorimotor mu component clusters in the right and left hemispheres. Event related spectral perturbation analyses indicated significantly stronger patterns of mu rhythm activity ( p FDR < 0.05) during the video condition as compared to the picture condition, specifically in the left hemisphere...
September 6, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28878159/connecting-the-dots-between-schizotypal-symptoms-and-social-anxiety-in-youth-with-an-extra-x-chromosome-a-mediating-role-for-catastrophizing
#9
Anne C Miers, Tim Ziermans, Sophie van Rijn
Youth with an extra X chromosome (47, XXY & 47, XXX) display higher levels of schizotypal symptoms and social anxiety as compared to typically developing youth. It is likely that the extra X chromosome group is at-risk for clinical levels of schizotypy and social anxiety. Hence, this study investigated how schizotypal and social anxiety symptoms are related and mechanisms that may explain their association in a group of 38 children and adolescents with an extra X chromosome and a comparison group of 109 typically developing peers (8-19 years)...
September 6, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28878146/computer-versus-compensatory-calendar-training-in-individuals-with-mild-cognitive-impairment-functional-impact-in-a-pilot-study
#10
Melanie J Chandler, Dona E C Locke, Noah L Duncan, Sherrie M Hanna, Andrea V Cuc, Julie A Fields, Charlene R Hoffman Snyder, Angela M Lunde, Glenn E Smith
This pilot study examined the functional impact of computerized versus compensatory calendar training in cognitive rehabilitation participants with mild cognitive impairment (MCI). Fifty-seven participants with amnestic MCI completed randomly assigned calendar or computer training. A standard care control group was used for comparison. Measures of adherence, memory-based activities of daily living (mADLs), and self-efficacy were completed. The calendar training group demonstrated significant improvement in mADLs compared to controls, while the computer training group did not...
September 6, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28862676/problems-in-classifying-mild-cognitive-impairment-mci-one-or-multiple-syndromes
#11
María Del Carmen Díaz-Mardomingo, Sara García-Herranz, Raquel Rodríguez-Fernández, César Venero, Herminia Peraita
As the conceptual, methodological, and technological advances applied to dementias have evolved the construct of mild cognitive impairment (MCI), one problem encountered has been its classification into subtypes. Here, we aim to revise the concept of MCI and its subtypes, addressing the problems of classification not only from the psychometric point of view or by using alternative methods, such as latent class analysis, but also considering the absence of normative data. In addition to the well-known influence of certain factors on cognitive function, such as educational level and cultural traits, recent studies highlight the relevance of other factors that may significantly affect the genesis and evolution of MCI: subjective memory complaints, loneliness, social isolation, etc...
September 1, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28829350/pathophysiology-and-neuroprotective-strategies-in-hypoxic-ischemic-brain-injury-and-stroke
#12
EDITORIAL
Bruno P Meloni
Hypoxic-ischemic brain injury and stroke are closely related and devastating conditions that can affect individuals of all ages.[...].
August 22, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28825647/alzheimer-s-disease-early-diagnosis-using-manifold-based-semi-supervised-learning
#13
Moein Khajehnejad, Forough Habibollahi Saatlou, Hoda Mohammadzade
Alzheimer's disease (AD) is currently ranked as the sixth leading cause of death in the United States and recent estimates indicate that the disorder may rank third, just behind heart disease and cancer, as a cause of death for older people. Clearly, predicting this disease in the early stages and preventing it from progressing is of great importance. The diagnosis of Alzheimer's disease (AD) requires a variety of medical tests, which leads to huge amounts of multivariate heterogeneous data. It can be difficult and exhausting to manually compare, visualize, and analyze this data due to the heterogeneous nature of medical tests; therefore, an efficient approach for accurate prediction of the condition of the brain through the classification of magnetic resonance imaging (MRI) images is greatly beneficial and yet very challenging...
August 20, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28825635/assessing-sensory-processing-dysfunction-in-adults-and-adolescents-with-autism-spectrum-disorder-a-scoping-review
#14
REVIEW
Denise DuBois, Erin Lymer, Barbara E Gibson, Pushpal Desarkar, Emily Nalder
Sensory reactivity is a diagnostic criterion for Autism Spectrum Disorder (ASD), and has been associated with poorer functional outcomes, behavioral difficulties, and autism severity across the lifespan. Yet, there is little consensus on best practice approaches to assessing sensory processing dysfunction in adolescents and adults with ASD. Despite growing evidence that sensory symptoms persist into adolescence and adulthood, there is a lack of norms for older age groups, and pediatric assessments may not target appropriate functional outcomes or environments...
August 19, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28820429/propofol-s-effects-on-the-fetal-brain-for-non-obstetric-surgery
#15
REVIEW
Ajay Malhotra, Emily Yosh, Ming Xiong
While the use of Propofol has been increasing in usage for general surgical procedures since its release to market, there has been little work done on its potential link to neurotoxicity in humans. Only recently, following the release of a warning label from the United States Food and Drug Administration (USFDA) regarding a potential link to "neurotoxicity" in the neonate, did the surgical and anesthesiology communities become more aware of its potential for harm. Given the widespread use of this drug in clinical practice, the warning label naturally raised controversy regarding intrapartum Propofol usage...
August 18, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28820427/a-review-of-the-neuropsychological-dimensions-of-tourette-syndrome
#16
REVIEW
Simon Morand-Beaulieu, Julie B Leclerc, Philippe Valois, Marc E Lavoie, Kieron P O'Connor, Bruno Gauthier
Neurocognitive functioning in Tourette syndrome (TS) has been the subject of intensive research in the past 30 years. A variety of impairments, presumably related to frontal and frontostriatal dysfunctions, have been observed. These impairments were found in various domains, such as attention, memory, executive functions, language, motor and visuomotor functions, among others. In line with contemporary research, other neurocognitive domains have recently been explored in TS, bringing evidence of altered social reasoning, for instance...
August 18, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28817065/evaluation-and-treatment-of-mild-traumatic-brain-injury-the-role-of-neuropsychology
#17
REVIEW
Carolyn Prince, Maya E Bruhns
Awareness of mild traumatic brain injury (mTBI) and persisting post-concussive syndrome (PCS) has increased substantially in the past few decades, with a corresponding increase in research on diagnosis, management, and treatment of patients with mTBI. The purpose of this article is to provide a narrative review of the current literature on behavioral assessment and management of patients presenting with mTBI/PCS, and to detail the potential role of neuropsychologists and rehabilitation psychologists in interdisciplinary care for this population during the acute, subacute, and chronic phases of recovery...
August 17, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28805746/melanocortins-melanocortin-receptors-and-multiple-sclerosis
#18
REVIEW
Robert P Lisak, Joyce A Benjamins
The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis. This review discusses corticosteroid dependent and independent effects of melanocortins on the peripheral immune system, central nervous system (CNS) effects mediated through neuronal regulation of immune system function, and direct effects on endogenous cells in the CNS. We have focused on the expression and function of melanocortin receptors in oligodendroglia (OL), the myelin producing cells of the CNS, with the goal of identifying new therapeutic approaches to decrease CNS damage in multiple sclerosis as well as to promote repair...
August 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28805718/myoclonic-disorders
#19
REVIEW
Olaf Eberhardt, Helge Topka
Few movement disorders seem to make a straightforward approach to diagnosis and treatment more difficult and frustrating than myoclonus, due to its plethora of causes and its variable classifications. Nevertheless, in recent years, exciting advances have been made in the elucidation of the pathophysiology and genetic basis of many disorders presenting with myoclonus. Here, we provide a review of all of the important types of myoclonus encountered in pediatric and adult neurology, with an emphasis on the recent developments that have led to a deeper understanding of this intriguing phenomenon...
August 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28805695/infants-investigated-by-the-child-welfare-system-exploring-a-distinct-profile-of-risks-service-needs-and-referrals-for-support-in-ontario
#20
Joanne Filippelli, Barbara Fallon, Esme Fuller-Thomson, Nico Trocmé
The science of early childhood development underscores that maltreatment and other adversities experienced during infancy heightens the risk for poor developmental and socio-emotional outcomes. Referrals to supportive services by the child welfare system are particularly critical during infancy given the rapidity of brain development and infants' sensitivity to their environment. The main objectives of the current study are to: (1) examine age-specific differences in clinical and case characteristics; (2) determine the factors associated with the service referral decision involving infants; and (3) explore the types of services families have been referred to at the conclusion of a maltreatment-related investigation...
August 12, 2017: Brain Sciences
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