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Journal of Materials Chemistry. B, Materials for Biology and Medicine

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https://www.readbyqxmd.com/read/29910955/towards-deployable-meta-implants
#1
F S L Bobbert, S Janbaz, A A Zadpoor
Meta-biomaterials exhibit unprecedented or rare combinations of properties not usually found in nature. Such unusual mechanical, mass transport, and biological properties could be used to develop novel categories of orthopedic implants with superior performance, otherwise known as meta-implants. Here, we use bi-stable elements working on the basis of snap-through instability to design deployable meta-implants. Deployable meta-implants are compact in their retracted state, allowing them to be brought to the surgical site with minimum invasiveness...
June 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29657715/multimodal-underwater-adhesion-using-self-assembled-dopa-bearing-aba-triblock-copolymer-networks
#2
Xiaomin Tang, Christopher J Bettinger
Self-assembled mechanically robust Dopa-bearing triblock copolymer networks improve underwater adhesion through both energy dissipation and interfacial bonding. Polymer networks that incorporate energy dissipating motifs could improve the performance of high-performance wet adhesives rather than only by interfacial bonds.
January 28, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29479429/impact-of-anti-biofouling-surface-coatings-on-the-properties-of-nanomaterials-and-their-biomedical-applications
#3
Yuancheng Li, Yaolin Xu, Candace C Fleischer, Jing Huang, Run Lin, Lily Yang, Hui Mao
Understanding and subsequently controlling non-specific interactions between engineered nanomaterials and biological environment have become increasingly important for further developing and advancing nanotechnology for biomedical applications. Such non-specific interactions, also known as the biofouling effect, mainly associate with the adsorption of biomolecules (such as proteins, DNAs, RNAs, and peptides) onto the surface of nanomaterials and the adhesion or uptake of nanomaterials by various cells. By altering the surface properties of nanomaterials the biofouling effect can lead to in situ changes of physicochemical properties, pharmacokinetics, functions, and toxicity of nanomaterials...
January 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29607047/fluorescent-probes-for-sensitive-and-selective-detection-of-ph-changes-in-live-cells-in-visible-and-near-infrared-channels
#4
Mingxi Fang, Rashmi Adhikari, Jianheng Bi, Wafa Mazi, Nethaniah Dorh, Jianbo Wang, Nathan Conner, Jon Ainsley, Tatyana G Karabencheva-Christova, Fen-Tair Luo, Ashutosh Tiwari, Haiying Liu
We report five fluorescent probes based on coumarin-hybridized fluorescent dyes with spirolactam ring structures (A-E) to detect pH changes in live cell by monitoring visible and near-infrared fluorescence changes. Under physiological or basic conditions, the fluorescent probes A, B, C, D and E preserve their spirolactam ring-closed forms and only display fluorescent peaks in the visible region corresponding to coumarin moieties at 497, 483, 498, 497 and 482 nm, respectively. However, at acidic pH, the rings of the spirolactam forms of the fluorescent probes A, B, C, D and E open up, generating new near-infrared fluorescence peaks at 711, 696, 707, 715, and 697 nm, respectively, through significantly extended π-conjugation to coumarin moieties of the fluorophores...
December 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29250331/dually-responsive-mesoporous-silica-nanoparticles-regulated-by-upper-critical-solution-temperature-polymers-for-intracellular-drug-delivery
#5
Mingyang Hei, Jun Wang, Kelly Wang, Weiping Zhu, Peter X Ma
We synthesized a new type of upper critical solution temperature (UCST) thermally responsive polymers (TRPs) with varying responsive temperatures (cloud points). We then grafted one of the TRPs with a cloud point of 42°C on the surface of mesoporous silica nanoparticles (MSN) using disulfide bonds to achieve a novel, dual responsive release system. With this system, the cargo release profiles are responsive to both temperature and reducing agents. When loaded with doxorubicin hydrochloride (DOX), the system could deliver DOX into breast cancer cells (SK-BR-3) in a controlled fashion and present high toxicity...
December 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29456858/enhanced-biostability-and-cellular-uptake-of-zinc-oxide-nanocrystals-shielded-with-a-phospholipid-bilayer
#6
B Dumontel, M Canta, H Engelke, A Chiodoni, L Racca, A Ancona, T Limongi, G Canavese, V Cauda
The widespread use of ZnO nanomaterials for biomedical applications, including therapeutic drug delivery or stimuli-responsive activation, as well as imaging, imposes a careful control over the colloidal stability and long-term behaviour of ZnO in biological media. Moreover, the effect of ZnO nanostructures on living cells, in particular cancer cells, is still under debate. This paper discusses the role of surface chemistry and charge of zinc oxide nanocrystals, of around 15 nm in size, which influence their behaviour in biological fluids and effect on cancer cells...
November 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29430301/l-carnitine-derived-zwitterionic-betaine-materials
#7
Wei Wang, Jianhai Yang, Ershuai Zhang, Yang Lu, Zhiqiang Cao
An L-carnitine derived zwitterionic betaine material was developed. The synthesized L-carnitineMA was the first zwitterionic betaine monomer from natural feedstocks. In the models of Surface coating and hydrogel, the L-carnitineMA material was able to achieve superior anti-fouling performance as good as state-of-the-art zwitterionic betaine materials.
November 12, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29255606/enhanced-cell-uptake-of-fluorescent-drug-loaded-nanoparticles-via-an-implantable-photothermal-fibrous-patch-for-more-effective-cancer-cell-killing
#8
Yangyang Li, Yike Fu, Zhaohui Ren, Xiang Li, Chuanbin Mao, Gaorong Han
Great efforts have been devoted to effective delivery of therapeutics into cells for cancer therapy. The exploration of nanoparticle based drug delivery systems (DDSs) faces daunting challenges in low efficacy of intracellular delivery. Herein, a localized drug delivery device consisting of photoluminescent mesoporous silica nanoparticles (PLMSNs) and photothermal fibrous matrix was investigated. Specifically, PLMSNs modified with a pH-sensitive polydopamine (PDA) 'gatekeeper' served as a doxorubicin (DOX) carrier and could release DOX once the PLMSNs were up-taken by the cancer cells...
September 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29230291/multifunctional-cu-39-s-28-hollow-nanopeanuts-for-in-vivo-targeted-photothermal-chemotherapy
#9
Lihua Li, Xianfeng Yang, Xiaoming Hu, Yao Lu, Liping Wang, Mingying Peng, Hong Xia, Qingshui Yin, Yu Zhang, Gang Han
Actively targeted hollow nanoparticles may play key roles in precise anti-cancer therapy. Here, unique Cu39 S28 hollow nanopeanuts (HNPs) were synthesized via a facile one-step method and the formation mechanism was illustrated. The as-synthesized Cu39 S28 HNPs exhibit outstanding photothermal conversion efficiency (41.1%) and drug storage capacity (DOX, 99.5 %). At the same time, the DOX drug loading nanocomposites have shown great sensitive response of release to either pH value or near infrared ray (NIR)...
September 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29276605/tyramine-functionalization-of-poly-glycerol-sebacate-increases-the-elasticity-of-the-polymer
#10
Xiaochu Ding, Yen-Lin Wu, Jin Gao, Albin Wells, Keewon Lee, Yadong Wang
Poly(glycerol sebacate) (PGS) is an elastomer used widely in tissue engineering studies due to good biocompatibility. Hereby we report a tyramine functionalized PGS called PGS-TA. Tyramine adds a stronger physical bonding capability to PGS-TA. Tensile tests showed that the softness and toughness of the material were similar to PGS. However, PGS-TA demonstrated 16-folds increase of elastic deformations compared to PGS processed under identical conditions. The in vitro studies demonstrated that the viability, and metabolic activity of baboon smooth muscle cells were the same as those on tissue culture polystyrene...
August 14, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29104753/antimicrobial-hydroxyapatite-gelatin-silica-composite-pastes-with-tunable-setting-properties
#11
Vuk Uskoković, Shreya Ghosh, Victoria M Wu
Bone grafting is one of the commonest surgical procedures, yet all bone substitutes developed so far suffer from specific weaknesses and the search for a bone graft material with ideal physical and biological properties is still ongoing. Calcium phosphate pastes are the most frequently used synthetic bone grafts, yet they (a) often take an impractically long time to set, (b) release the drug content too fast, and (c) do not form pores large enough to accommodate host cells and foster osseointegration. To make up for these deficiencies, we introduced gelatin and silica to pastes composed of 5-15 nm sized hydroxyapatite nanoparticles and yielded a bioresorbable composite that is compact, yet flowing upon injection; that prevents setting at room temperature, but sets promptly, in minutes, at 37 °C; that displays an increase in surface porosity following immersion in physiological fluids; that allows for sustained release of antibiotics; and that sets in a tunable manner and in clinically relevant time windows: 1-3 minutes at its fastest...
August 14, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28868145/co-delivery-of-paclitaxel-and-cisplatin-with-biocompatible-plga-peg-nanoparticles-enhances-chemoradiotherapy-in-non-small-cell-lung-cancer-models
#12
Jing Tian, Yuanzeng Min, Zachary Rodgers, Kin Man Au, C Tilden Hagan, Maofan Zhang, Kyle Roche, Feifei Yang, Kyle Wagner, Andrew Z Wang
Chemoradiotherapy (CRT) with paclitaxel (PTX) and cisplatin (CP) is part of the standard of care for patients with locally advanced non-small cell lung cancer (NSCLC). Despite the high treatment intensity, many patients still develop local recurrence after treatment. Thus, there is a strong need to further improve CRT for lung cancer. One strategy is to co-deliver cytotoxic chemotherapy agents using biocompatible nanoparticles (NPs) which can limit off-target tissue toxicity and improve therapeutic efficacy...
August 14, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29081976/oral-delivery-of-curcumin-via-porous-polymeric-nanoparticles-for-effective-ulcerative-colitis-therapy
#13
Qiubing Chen, Xiaoying Si, Lijun Ma, Panpan Ma, Meili Hou, Shuang Bai, Xiaoshuai Wu, Ying Wan, Bo Xiao, Didier Merlin
Oral drug delivery has been considered as a promising strategy for ulcerative colitis (UC) therapy. Here, an emulsion solvent evaporation technique was employed to prepare non-porous curcumin (CUR)-loaded polymeric nanoparticles (NPs) and porous CUR-loaded polymeric NPs in the absence or presence of ammonium bicarbonate. The resultant CUR-loaded NPs (non-porous NPs and porous NPs) had a desirable mean particle size of around 260 nm with a narrow size distribution, a uniform pore size distribution, slightly negative-charged surface, high encapsulation efficiency and controlled drug release capacity...
August 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28848651/a-general-strategy-for-generating-gradients-of-bioactive-proteins-on-electrospun-nanofiber-mats-by-masking-with-bovine-serum-albumin
#14
Michael L Tanes, Jiajia Xue, Younan Xia
Electrospun nanofibers are widely used in tissue engineering owing to their capability to mimic the structures and architectures of various types of extracellular matrices. However, it has been difficult to incorporate a biochemical cue into the physical cue provided by the nanofibers. Here we report a simple and versatile method for generating gradients of bioactive proteins on nanofiber mats. We establish that the adsorption of bovine serum albumin (BSA) onto nanofibers is a time- and concentration-dependent process...
July 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29170716/poss-prodot-crosslinking-of-pedot
#15
Bin Wei, Jinglin Liu, Liangqi Ouyang, David C Martin
Alkoxy-functionalized polythiophenes such as poly(3,4-ethylenedioxythiophene) (PEDOT) and poly(3,4-propylenedioxythiophene) (PProDOT) have become promising materials for a variety of applications including bioelectronic devices due to their high conductivity, relatively soft mechanical response, good chemical stability and excellent biocompatibility. However the long-term applications of PEDOT and PProDOT coatings are still limited by their relatively poor electrochemical stability on various inorganic substrates...
July 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29308203/gold-iron-oxide-dimers-for-magnetic-hyperthermia-the-key-role-of-chloride-ions-in-the-synthesis-to-boost-the-heating-efficiency
#16
P Guardia, S Nitti, M E Materia, G Pugliese, N Yaacoub, J-M Greneche, C Lefevre, L Manna, T Pellegrino
With the aim of producing Au-Fe x O y dimers with outstanding heating performances under magnetic hyperthermia conditions applicable to human patients, here we report two synthesis routes, a two-pot and a one-pot method. The addition of chloride ions and the absence of 1,2-hexadecanediol (HDDOL), a commonly used chemical in this synthesis, are the key factors that enable us to produce dimers at low temperature with crystalline iron oxide domains in the size range between 18-39 nm that is ideal for magnetic hyperthermia...
June 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29098078/simulation-of-ecm-with-silk-and-chitosan-nanocomposite-materials
#17
Z Z Ding, J Ma, W He, Z L Ge, Q Lu, D L Kaplan
Extracellular matrix (ECM) is a system used to model the design of biomaterial matrices for tissue regeneration. Various biomaterial systems have been developed to mimic the composition or microstructure of the ECM. However, emulating multiple facets of the ECM in these systems remains a challenge. Here, a new strategy is reported which addresses this need by using silk fibroin and chitosan (CS) nanocomposite materials. Silk fibroin was first assembled into ECM-mimetic nanofibers in water and then blended with CS to introduce the nanostructural cues...
June 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28966791/janus-nanoparticles-for-t-cell-activation-clustering-ligands-to-enhance-stimulation
#18
Kwahun Lee, Yan Yu
The in vitro activation of T cells by synthetic particles is a promising technique for adoptive cancer immunotherapy. While it is known that cell-surface receptors form clusters during T cell activation, the use of clustered ligands on synthetic particles to modulate T cell response is a largely unexplored concept. Building upon our previous finding that T cells respond differently to various micro-sized patterns of ligands, we here investigate the effect of nano-sized ligand clusters on T cell activation. Two-faced Janus nanoparticles were fabricated to display ligands of different functions in spatially segregated clusters on single nanoparticles...
June 21, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28652916/tunable-delayed-controlled-release-profile-from-layered-polymeric-microparticles
#19
D Dutta, C Fauer, K Hickey, M Salifu, S E Stabenfeldt
Composite microparticles (MPs) with layered architecture, engineered from poly(L-lactic acid) (PLLA) and poly(D,L-lactic-co-glycolic acid) (PLGA), are promising devices for achieving the delayed release of proteins. Here, we build on a water-in-oil-in-oil-in-water emulsion method of fabricating layered MPs with an emphasis on modulating the delay period of the protein release profile. Particle hardening parameters (i.e. polymer precipitation rate and total hardening time) following water-in-oil-in-oil-in-water emulsions are known to affect MP structure such as the core/shell material and cargo localization...
June 21, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29170715/biocompatible-degradable-thermoplastic-polyurethane-based-on-polycaprolactone-block-polytetrahydrofuran-block-polycaprolactone-copolymers-for-soft-tissue-engineering
#20
Hao-Yang Mi, Xin Jing, Brett N Napiwocki, Breanna S Hagerty, Guojun Chen, Lih-Sheng Turng
Biodegradable synthetic polymers have been widely used as tissue engineering scaffold materials. Even though they have shown excellent biocompatibility, they have failed to resemble the low stiffness and high elasticity of soft tissues because of the presence of massive rigid ester bonds. Herein, we synthesized a new thermoplastic polyurethane elastomer (CTC-PU(BET)) using poly ester ether triblock copolymer (polycaprolactone-block-polytetrahydrofuran-block-polycaprolactone triblock copolymer, PCTC) as the soft segment, aliphatic diisocyanate (hexamethylene diisocyanate, HDI) as the hard segment, and degradable diol (bis(2-hydroxyethyl) terephthalate, BET) as the chain extender...
June 14, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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