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Journal of Materials Chemistry. B, Materials for Biology and Medicine

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https://www.readbyqxmd.com/read/30283632/elastic-serum-albumin-based-hydrogels-mechanism-of-formation-and-application-in-cardiac-tissue-engineering
#1
Nadav Amdursky, Manuel M Mazo, Michael R Thomas, Eleanor J Humphrey, Jennifer L Puetzer, Jean-Philippe St-Pierre, Stacey C Skaalure, Robert M Richardson, Cesare M Terracciano, Molly M Stevens
Hydrogels are promising materials for mimicking the extra-cellular environment. Here, we present a simple methodology for the formation of a free-standing viscoelastic hydrogel from the abundant and low cost protein serum albumin. We show that the mechanical properties of the hydrogel exhibit a complicated behaviour as a function of the weight fraction of the protein component. We further use X-ray scattering to shed light on the mechanism of gelation from the formation of a fibrillary network at low weight fractions to interconnected aggregates at higher weight fractions...
September 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30386619/antibacterial-and-potentiation-properties-of-charge-optimized-polyrotaxanes-for-combating-opportunistic-bacteria
#2
Jing Qiao, Zhi Liu, Max Purro, May P Xiong
Bacteria are now becoming more resistant to most conventional antibiotics. Approaches for the treatment of multidrug-resistant bacterial infections are urgently required. Cationic polymers have broad-spectrum antibacterial activity but can also induce non-specific damage to mammalian cells. Herein, we report on the design of cationic polyrotaxanes (cPRs) with variable charge densities. cPRs were prepared by conjugating neutral ethanolamine and cationic ethylenediamine at various ratios onto threaded alpha-cyclodextrins and their antimicrobial and cytocompatible properties were investigated in vitro...
September 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30245822/cancer-cell-targeting-controlled-drug-release-and-intracellular-fate-of-biomimetic-membrane-encapsulated-drug-loaded-nano-graphene-oxide-nanohybrids
#3
Kun Ma, Duo Fu, Yajun Liu, Rui Dai, Dongli Yu, Zhaoming Guo, Changhao Cui, Li Wang, Jinaqiang Xu, Chuanbin Mao
Nano-graphene oxide (NGO) has been proposed as a novel drug carrier. However, the poor biocompatibility and physiological stability as well as lack of cancer targeting capability have limited its further applications in cancer therapy. To solve this problem, we developed a novel nanohybrid of NGO/DOX@SPC-FA by first allowing soy phosphatidylcholine membrane (SPC) to encapsulate DOX-loaded NGO (NGO/DOX) and then modifying the SPC membrane with PEGylated lipid-FA conjugate to achieve the display of cancer targeting FA on the nanohybrid surface...
August 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29910955/towards-deployable-meta-implants
#4
F S L Bobbert, S Janbaz, A A Zadpoor
Meta-biomaterials exhibit unprecedented or rare combinations of properties not usually found in nature. Such unusual mechanical, mass transport, and biological properties could be used to develop novel categories of orthopedic implants with superior performance, otherwise known as meta-implants. Here, we use bi-stable elements working on the basis of snap-through instability to design deployable meta-implants. Deployable meta-implants are compact in their retracted state, allowing them to be brought to the surgical site with minimum invasiveness...
June 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30345059/impedance-spectroscopic-detection-of-binding-and-reactions-in-acid-labile-dielectric-polymers-for-biosensor-applications
#5
Jennifer Dailey, Michelangelo Fichera, Ellen Silbergeld, Howard Katz
We synthesized previously unreported copolymers with cleavable acid-labile side chains for use as electrochemical sensing layers in order to demonstrate a novel architecture for a one-step immunosensor. This one-step system is in contrast to most antigen-capture signal amplification methods that involve complicated secondary labeling techniques, or require the addition of redox probes to achieve a sensing response. A series of novel copolymers composed of various trityl-containing monomers were synthesized and characterized to determine their dielectric properties...
May 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30345058/bioactive-silk-hydrogels-with-tunable-mechanical-properties
#6
Xue Wang, Zhaozhao Ding, Chen Wang, Xiangdong Chen, Hui Xu, Qiang Lu, David L Kaplan
Developing bioactive hydrogels with potential to guide the differentiation behavior of stem cells has become increasingly important in the biomaterials field. Here, silk hydrogels with tunable mechanical properties were developed by introducing inert silk fibroin nanofibers (SNF) within an enzyme crosslinked system of regenerated silk fibroin (RSF). After the crosslinking reaction of RSF, the inert SNF was embedded into the RSF hydrogel matrix, resulting in improved mechanical properties. Tunable stiffness in the range of 9-60 KPa was achieved by adjusting the amount of the added NSF, significantly higher than SNF-free hydrogels formed under same conditions (about 1 KPa)...
May 14, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30319779/nanoscale-3d-printing-of-hydrogels-for-cellular-tissue-engineering
#7
Shangting You, Jiawen Li, Wei Zhu, Claire Yu, Deqing Mei, Shaochen Chen
Hydrogel scaffolds that mimic the native extracellular matrix (ECM) environment is a crucial part of tissue engineering. It has been demonstrated that cell behaviors can be affected by not only the hydrogel's physical and chemical properties, but also its three dimensional (3D) geometrical structures. In order to study the influence of 3D geometrical cues on cell behaviors as well as the maturation and function of engineered tissues, it is imperative to develop 3D fabrication techniques to create micro and nanoscale hydrogel constructs...
April 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30294445/the-in-vivo-fates-of-plant-viral-nanoparticles-camouflaged-using-self-proteins-overcoming-immune-recognition
#8
N M Gulati, A S Pitek, A E Czapar, P L Stewart, N F Steinmetz
Nanoparticles offer a promising avenue for targeted delivery of therapies. To slow clearance, nanoparticles are frequently stealth-coated to prevent opsonization and immune recognition. Serum albumin (SA) has been used as a bio-inspired stealth coating. To develop this shielding strategy for clinical applications, it is critical to understand the interactions between the immune system and SA-camouflaged nanoparticles. This work investigates the in vivo processing of SA-coated nanoparticles using tobacco mosaic virus (TMV) as a model system...
April 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30221004/time-lapse-live-cell-imaging-to-monitor-doxorubicin-release-from-dna-origami-nanostructures
#9
Yun Zeng, Jiajun Liu, Shuo Yang, Wenyan Liu, Liang Xu, Risheng Wang
Self-assembled DNA nanostructures have attracted significant research interest in biomedical applications because of their excellent programmability and biocompatibility. To develop multifunctional drug delivery from DNA nanostructures, considerable key information is still needed for clinical application. Traditional fixed endpoint assays do not reflect the dynamic and heterogeneous responses of cells with regard to drugs, and may lead to the misinterpretation of experimental results. For the first time, an integrated time-lapse live cell imaging system was used to study the cellular internalization and controlled drug release profile of three different shaped DNA origami/doxorubicin (DOX) complexes for three days...
March 21, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30034807/advances-in-plant-derived-edible-nanoparticle-based-lipid-nano-drug-delivery-systems-as-therapeutic-nanomedicines
#10
Chunhua Yang, Mingzhen Zhang, Didier Merlin
Plant-derived edible nanoparticles (PDNPs) are nano-sized membrane vesicles released by edible plants, such as grapefruit, ginger, broccoli, and lemon. They are non-toxic, have tissue-specific targeting properties, and can be mass-produced. Thus, they have great potential for clinical application. PDNPs offer multiple advantages over the currently available drug delivery systems, such as their relatively high internalization rate, low immunogenicity, proven stability in the gastrointestinal (GI) tract, and ability to overcome the blood-brain barrier but not cross the placental barrier...
March 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29657715/multimodal-underwater-adhesion-using-self-assembled-dopa-bearing-aba-triblock-copolymer-networks
#11
Xiaomin Tang, Christopher J Bettinger
Self-assembled mechanically robust Dopa-bearing triblock copolymer networks improve underwater adhesion through both energy dissipation and interfacial bonding. Polymer networks that incorporate energy dissipating motifs could improve the performance of high-performance wet adhesives rather than only by interfacial bonds.
January 28, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29479429/impact-of-anti-biofouling-surface-coatings-on-the-properties-of-nanomaterials-and-their-biomedical-applications
#12
Yuancheng Li, Yaolin Xu, Candace C Fleischer, Jing Huang, Run Lin, Lily Yang, Hui Mao
Understanding and subsequently controlling non-specific interactions between engineered nanomaterials and biological environment have become increasingly important for further developing and advancing nanotechnology for biomedical applications. Such non-specific interactions, also known as the biofouling effect, mainly associate with the adsorption of biomolecules (such as proteins, DNAs, RNAs, and peptides) onto the surface of nanomaterials and the adhesion or uptake of nanomaterials by various cells. By altering the surface properties of nanomaterials the biofouling effect can lead to in situ changes of physicochemical properties, pharmacokinetics, functions, and toxicity of nanomaterials...
January 7, 2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/30420913/smart-gold-nanoparticle-stabilized-ultrasound-microbubbles-as-cancer-theranostics
#13
Young Il Yoon, Xin Pang, Sungwook Jung, Guofeng Zhang, Minsuk Kong, Gang Liu, Xiaoyuan Chen
Smart gold nanoparticle-stabilized microbubbles (SAuMBs) composed of a gas-filled core and shell including smart gold nanoparticles (SAuNPs) which can be aggregated in tumors were applied as ultrasound-mediated cancer theranostics. The gas core in the microstructure enabled the detection of tumors using ultrasound and facilitated the delivery of SAuNPs by sonoporation. The SAuNPs spontaneously aggregated in tumors, which allowed photoacoustic (PA) monitoring and photothermal treatment (PTT) of tumors.
2018: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29607047/fluorescent-probes-for-sensitive-and-selective-detection-of-ph-changes-in-live-cells-in-visible-and-near-infrared-channels
#14
Mingxi Fang, Rashmi Adhikari, Jianheng Bi, Wafa Mazi, Nethaniah Dorh, Jianbo Wang, Nathan Conner, Jon Ainsley, Tatyana G Karabencheva-Christova, Fen-Tair Luo, Ashutosh Tiwari, Haiying Liu
We report five fluorescent probes based on coumarin-hybridized fluorescent dyes with spirolactam ring structures (A-E) to detect pH changes in live cell by monitoring visible and near-infrared fluorescence changes. Under physiological or basic conditions, the fluorescent probes A, B, C, D and E preserve their spirolactam ring-closed forms and only display fluorescent peaks in the visible region corresponding to coumarin moieties at 497, 483, 498, 497 and 482 nm, respectively. However, at acidic pH, the rings of the spirolactam forms of the fluorescent probes A, B, C, D and E open up, generating new near-infrared fluorescence peaks at 711, 696, 707, 715, and 697 nm, respectively, through significantly extended π-conjugation to coumarin moieties of the fluorophores...
December 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29250331/dually-responsive-mesoporous-silica-nanoparticles-regulated-by-upper-critical-solution-temperature-polymers-for-intracellular-drug-delivery
#15
Mingyang Hei, Jun Wang, Kelly Wang, Weiping Zhu, Peter X Ma
We synthesized a new type of upper critical solution temperature (UCST) thermally responsive polymers (TRPs) with varying responsive temperatures (cloud points). We then grafted one of the TRPs with a cloud point of 42°C on the surface of mesoporous silica nanoparticles (MSN) using disulfide bonds to achieve a novel, dual responsive release system. With this system, the cargo release profiles are responsive to both temperature and reducing agents. When loaded with doxorubicin hydrochloride (DOX), the system could deliver DOX into breast cancer cells (SK-BR-3) in a controlled fashion and present high toxicity...
December 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29456858/enhanced-biostability-and-cellular-uptake-of-zinc-oxide-nanocrystals-shielded-with-a-phospholipid-bilayer
#16
B Dumontel, M Canta, H Engelke, A Chiodoni, L Racca, A Ancona, T Limongi, G Canavese, V Cauda
The widespread use of ZnO nanomaterials for biomedical applications, including therapeutic drug delivery or stimuli-responsive activation, as well as imaging, imposes a careful control over the colloidal stability and long-term behaviour of ZnO in biological media. Moreover, the effect of ZnO nanostructures on living cells, in particular cancer cells, is still under debate. This paper discusses the role of surface chemistry and charge of zinc oxide nanocrystals, of around 15 nm in size, which influence their behaviour in biological fluids and effect on cancer cells...
November 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29430301/l-carnitine-derived-zwitterionic-betaine-materials
#17
Wei Wang, Jianhai Yang, Ershuai Zhang, Yang Lu, Zhiqiang Cao
An L-carnitine derived zwitterionic betaine material was developed. The synthesized L-carnitineMA was the first zwitterionic betaine monomer from natural feedstocks. In the models of Surface coating and hydrogel, the L-carnitineMA material was able to achieve superior anti-fouling performance as good as state-of-the-art zwitterionic betaine materials.
November 12, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29255606/enhanced-cell-uptake-of-fluorescent-drug-loaded-nanoparticles-via-an-implantable-photothermal-fibrous-patch-for-more-effective-cancer-cell-killing
#18
Yangyang Li, Yike Fu, Zhaohui Ren, Xiang Li, Chuanbin Mao, Gaorong Han
Great efforts have been devoted to effective delivery of therapeutics into cells for cancer therapy. The exploration of nanoparticle based drug delivery systems (DDSs) faces daunting challenges in low efficacy of intracellular delivery. Herein, a localized drug delivery device consisting of photoluminescent mesoporous silica nanoparticles (PLMSNs) and photothermal fibrous matrix was investigated. Specifically, PLMSNs modified with a pH-sensitive polydopamine (PDA) 'gatekeeper' served as a doxorubicin (DOX) carrier and could release DOX once the PLMSNs were up-taken by the cancer cells...
September 28, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29230291/multifunctional-cu-39-s-28-hollow-nanopeanuts-for-in-vivo-targeted-photothermal-chemotherapy
#19
Lihua Li, Xianfeng Yang, Xiaoming Hu, Yao Lu, Liping Wang, Mingying Peng, Hong Xia, Qingshui Yin, Yu Zhang, Gang Han
Actively targeted hollow nanoparticles may play key roles in precise anti-cancer therapy. Here, unique Cu39 S28 hollow nanopeanuts (HNPs) were synthesized via a facile one-step method and the formation mechanism was illustrated. The as-synthesized Cu39 S28 HNPs exhibit outstanding photothermal conversion efficiency (41.1%) and drug storage capacity (DOX, 99.5 %). At the same time, the DOX drug loading nanocomposites have shown great sensitive response of release to either pH value or near infrared ray (NIR)...
September 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29276605/tyramine-functionalization-of-poly-glycerol-sebacate-increases-the-elasticity-of-the-polymer
#20
Xiaochu Ding, Yen-Lin Wu, Jin Gao, Albin Wells, Keewon Lee, Yadong Wang
Poly(glycerol sebacate) (PGS) is an elastomer used widely in tissue engineering studies due to good biocompatibility. Hereby we report a tyramine functionalized PGS called PGS-TA. Tyramine adds a stronger physical bonding capability to PGS-TA. Tensile tests showed that the softness and toughness of the material were similar to PGS. However, PGS-TA demonstrated 16-folds increase of elastic deformations compared to PGS processed under identical conditions. The in vitro studies demonstrated that the viability, and metabolic activity of baboon smooth muscle cells were the same as those on tissue culture polystyrene...
August 14, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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