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JACC. Heart Failure

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https://www.readbyqxmd.com/read/29032139/effects-of-vildagliptin-on-ventricular-function-in-patients-with-type-2-diabetes%C3%A2-mellitus-and-heart-failure-a-randomized-placebo-controlled-trial
#1
John J V McMurray, Piotr Ponikowski, Geremia B Bolli, Valentina Lukashevich, Plamen Kozlovski, Wolfgang Kothny, James D Lewsey, Henry Krum
OBJECTIVES: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction. BACKGROUND: Many patients with type 2 diabetes mellitus have heart failure and it is important to know about the safety of new treatments for diabetes in these individuals. METHODS: Patients 18 to 85 years of age with type 2 diabetes and heart failure (New York Heart Association functional class I to III and left ventricular ejection fraction [LVEF] <0...
October 11, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032141/moderate-alcohol-consumption-is%C3%A2-associated-with-lower-risk-for-heart%C3%A2-failure-but-not-atrial-fibrillation
#2
Augusto Di Castelnuovo, Simona Costanzo, Marialaura Bonaccio, Livia Rago, Amalia De Curtis, Mariarosaria Persichillo, Francesca Bracone, Marco Olivieri, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
OBJECTIVES: The aim of this study was to assess the hypothesis that alcohol consumption is associated with onset of atrial fibrillation (AF) and/or heart failure (HF). BACKGROUND: The connection between ethanol intake and AF or HF remains controversial. METHODS: The study population was 22,824 AF- or HF-free subjects (48% men, age ≥35 years) randomly recruited from the general population included in the Moli-sani study, for whom complete data on HF, AF, and alcohol consumption were available...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032140/heart-failure-with-mid-range-borderline-ejection-fraction-clinical-implications-and-future-directions
#3
REVIEW
Jeffrey J Hsu, Boback Ziaeian, Gregg C Fonarow
Heart failure (HF) with borderline ejection fraction was first defined in 2013 in the American College of Cardiology/American Heart Association guidelines as the presence of the typical symptoms of HF and a left ventricular ejection fraction (LVEF) of 41% to 49%. In 2016, the European Society of Cardiology specified HF with mid-range ejection fraction (HFmrEF) as LVEF of 40% to 49%. This range of LVEF is less well studied compared with HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF)...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032138/wedge-pressure-rather-than-left%C3%A2-ventricular-end-diastolic-pressure-predicts-outcome-in-heart-failure-with-preserved-ejection-fraction
#4
Julia Mascherbauer, Caroline Zotter-Tufaro, Franz Duca, Christina Binder, Matthias Koschutnik, Andreas A Kammerlander, Stefan Aschauer, Diana Bonderman
OBJECTIVES: This study sought to compare the prognostic power of left ventricular end-diastolic pressure (LVEDP) and pulmonary arterial wedge pressure (PAWP) in heart failure with preserved ejection fraction (HFpEF). BACKGROUND: It is broadly accepted that direct measurement of LVEDP in HFpEF more robustly reflects left ventricular hemodynamics than PAWP. METHODS: A total of 173 consecutive HFpEF patients were prospectively enrolled. Of these, 152 patients fulfilled registry inclusion criteria...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032137/the-risks-and-benefits-of-moderate%C3%A2-alcohol-consumption-there-remains-much-to-learn
#5
EDITORIAL
Eric S Leifer
No abstract text is available yet for this article.
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032136/a-multicenter-randomized-double-blind-placebo-controlled-trial-of-the-efficacy%C3%A2-and-safety-of-the-oral-soluble-guanylate-cyclase-stimulator-the-victoria-trial
#6
REVIEW
Paul W Armstrong, Lothar Roessig, Mahesh J Patel, Kevin J Anstrom, Javed Butler, Adriaan A Voors, Carolyn S P Lam, Piotr Ponikowski, Tracy Temple, Burkert Pieske, Justin Ezekowitz, Adrian F Hernandez, Joerg Koglin, Christopher M O'Connor
This trial sought to evaluate whether vericiguat, a novel oral soluble guanylate cyclase (sGC) stimulator, was superior to placebo, on a background of standard of care, in increasing the time to the first occurrence of the composite endpoints of cardiovascular (CV) death and heart failure (HF) hospitalization in patients with HF with reduced ejection fraction (HFrEF). Deficiency in sGC-derived cyclic guanosine monophosphate (cGMP) causes both myocardial dysfunction and impaired endothelium-dependent vasomotor regulation that includes the myocardial microcirculation...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032135/glucose-lowering-therapies-in-patients%C3%A2-with-concomitant-diabetes%C3%A2-mellitus-and-heart-failure-finding-the-sweet-spot
#7
EDITORIAL
Javed Butler, Muthiah Vaduganathan
No abstract text is available yet for this article.
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032134/left-ventricular-filling-pressures-in%C3%A2-heart%C3%A2-failure-with-preserved-ejection%C3%A2-fraction-is-the-tail-now-wagging-the-dog
#8
EDITORIAL
Masaru Obokata, Barry A Borlaug
No abstract text is available yet for this article.
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032133/heart-rate-in-preserved-ejection%C3%A2-fraction%C3%A2-heart-failure
#9
EDITORIAL
Michael R Bristow, Natasha L Altman
No abstract text is available yet for this article.
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032132/prognostic-importance-of-temporal-changes-in-resting-heart-rate-in-heart-failure-and-preserved-ejection-fraction-from-the-topcat-study
#10
Ali Vazir, Brian Claggett, Bertram Pitt, Inder Anand, Nancy Sweitzer, James Fang, Jerome Fleg, Jean Rouleau, Sanjiv Shah, Marc A Pfeffer, Scott D Solomon
OBJECTIVES: The aim of this study was to examine the relationship between baseline heart rate (HR), change in HR from a preceding visit, and time-updated HR with subsequent outcomes in patients with heart failure with preserved ejection fraction (HFpEF) in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) trial. BACKGROUND: Higher resting HR and increase in HR over time in patients with heart failure are associated with adverse outcomes...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29032131/association-between-type-2-diabetes-and-all-cause-hospitalization-and-mortality-in-the-uk-general-heart-failure-population-stratification-by-diabetic-glycemic-control-and-medication%C3%A2-intensification
#11
Claire A Lawson, Peter W Jones, Lucy Teece, Sandra B Dunbar, Petar M Seferovic, Kamlesh Khunti, Mamas Mamas, Umesh T Kadam
OBJECTIVES: This study sought to investigate in the general heart failure (HF) population, whether the associations between type 2 diabetes (T2D) and risk of hospitalization and death, are modified by changing glycemic or drug treatment intensity. BACKGROUND: In the general HF population, T2D confers a higher risk of poor outcomes, but whether this risk is modified by the diabetes status is unknown. METHODS: A nested case-control study in an incident HF database cohort (2002 to 2014) comparing patients with T2D with those without, for risk of all-cause first hospitalization and death...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28822747/why-ruin-a-good-story-with-a-few-facts
#12
EDITORIAL
Maria Rosa Costanzo
No abstract text is available yet for this article.
August 3, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28822746/outcomes-of-early-adolescent-donor-hearts-in-adult-transplant-recipients
#13
Shivank Madan, Snehal R Patel, Peter Vlismas, Omar Saeed, Sandhya Murthy, Stephen Forest, William Jakobleff, Daniel Sims, Jacqueline M Lamour, Daphne T Hsu, Julia Shin, Daniel Goldstein, Ulrich P Jorde
OBJECTIVES: This study sought to determine outcomes of adult recipients of early adolescent (EA) (10 to 14 years) donor hearts. BACKGROUND: Despite a shortage of donor organs, EA donor hearts (not used for pediatric patients) are seldom used for adults because of theoretical concerns for lack of hormonal activation and changes in left ventricular mass. Nonetheless, the outcomes of adult transplantation using EA donor hearts are not clearly established. METHODS: All adult (≥18 years of age) heart transplant recipients in the United Network for Organ Sharing database between April 1994 and September 2015 were eligible for this analysis...
August 3, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28822744/aldosterone-renin-cardiovascular-events-and-all-cause-mortality-among-african%C3%A2-americans-the-jackson-heart-study
#14
Joshua J Joseph, Justin B Echouffo-Tcheugui, Rita R Kalyani, Hsin-Chieh Yeh, Alain G Bertoni, Valery S Effoe, Ramon Casanova, Mario Sims, Wen-Chih Wu, Gary S Wand, Adolfo Correa, Sherita H Golden
OBJECTIVES: This study examined the association of aldosterone and plasma renin activity (PRA) with incident cardiovascular disease (CVD), using a composite endpoint of coronary heart disease, stroke, and/or heart failure and mortality among African Americans in the Jackson Heart Study. BACKGROUND: There is a paucity of data for the association of aldosterone and PRA with incident CVD or all-cause mortality among community-dwelling African Americans. METHODS: A total of 4,985 African American adults, 21 to 94 years of age, were followed for 12 years...
August 3, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28958354/reply-who-will-be-rehospitalized-next-targeting-heart-failure-patients-with-brittle%C3%A2-dimensions
#15
LETTER
Maneesh Sud, Bing Yu, Harindra C Wijeysundera, Peter C Austin, Dennis T Ko, Juarez Braga, Peter Cram, John A Spertus, Michael Domanski, Douglas S Lee
No abstract text is available yet for this article.
October 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28958353/who-will-be-rehospitalized-next-targeting-heart-failure-patients-with-brittle%C3%A2-dimensions
#16
LETTER
Atsushi Tanaka, Koichi Node
No abstract text is available yet for this article.
October 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28958352/q-a-with-the-jacc-heart%C3%A2-failure-editor-in-chief-marking-the-5-year-milestone
#17
EDITORIAL
Christopher M O'Connor
No abstract text is available yet for this article.
October 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28958351/a-what
#18
LETTER
Reiss Tatum
No abstract text is available yet for this article.
October 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28958350/using-30-day-mortality-to-measure-quality%C3%A2-of-heart-failure-care
#19
EDITORIAL
Paul Heidenreich
No abstract text is available yet for this article.
October 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28958349/variation-in-do-not-resuscitate-orders-and%C3%A2-implications-for-heart-failure-risk-adjusted-hospital-mortality-metrics
#20
Jeffrey Bruckel, Anuj Mehta, Steven M Bradley, Sabu Thomas, Charles J Lowenstein, Brahmajee K Nallamothu, Allan J Walkey
OBJECTIVES: This study evaluated the effect of patient do-not-resuscitate (DNR) status on hospital risk-adjusted heart failure mortality metrics. BACKGROUND: Do-not-resuscitate orders limit the use of life-sustaining therapies. Patients with DNR orders have increased in-hospital mortality, and DNR rates vary among hospitals. Variations in DNR rates could strongly confound risk-adjusted hospital mortality rates for heart failure. METHODS: We identified a cohort of adults with primary diagnosis of heart failure by using the 2011 California State Inpatient Database, a claims database that captures "early DNR," within 24 h of admission...
October 2017: JACC. Heart Failure
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