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JACC. Heart Failure

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https://www.readbyqxmd.com/read/29428439/using-nt-probnp-for-eligibility-and%C3%A2-enrichment-in-trials-in-hfpef-hfmref-%C3%A2-and-hfref
#1
Gianluigi Savarese, Nicola Orsini, Camilla Hage, Ola Vedin, Francesco Cosentino, Giuseppe M C Rosano, Ulf Dahlström, Lars H Lund
OBJECTIVES: The purpose of this study was to assess the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiovascular (CV) versus non-CV events and between NT-proBNP and potential treatment effects in heart failure (HF) with preserved, mid-range, and reduced ejection fraction (HFpEF, HFmrEF, and HFrEF, respectively) and clinically relevant subgroups. BACKGROUND: Optimizing patient eligibility criteria in HF trials requires biomarkers that enrich for CV but not for non-CV events and select patients most likely to respond to the tested intervention...
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428438/no-obesity-paradox-in-pediatric-patients-with-dilated-cardiomyopathy
#2
Chesney D Castleberry, John L Jefferies, Ling Shi, James D Wilkinson, Jeffrey A Towbin, Ryan W Harrison, Joseph W Rossano, Elfriede Pahl, Teresa M Lee, Linda J Addonizio, Melanie D Everitt, Justin Godown, Joseph Mahgerefteh, Paolo Rusconi, Charles E Canter, Steven D Colan, Paul F Kantor, Hiedy Razoky, Steven E Lipshultz, Tracie L Miller
OBJECTIVES: This study aimed to examine the role of nutrition in pediatric dilated cardiomyopathy (DCM). BACKGROUND: In adults with DCM, malnutrition is associated with mortality, whereas obesity is associated with survival. METHODS: The National Heart, Lung, and Blood Institute-funded Pediatric Cardiomyopathy Registry was used to identify patients with DCM and categorized by anthropometric measurements: malnourished (MN) (body mass index [BMI] <5% for ≥2 years or weight-for-length <5% for <2 years), obesity (BMI >95% for age ≥2 years or weight-for-length >95% for <2 years), or normal bodyweight (NB)...
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428437/obesity-and-prognosis-in-pediatric-dilated-cardiomyopathy-no-paradox-or-adverse-effects
#3
EDITORIAL
Carl J Lavie, Hector O Ventura
No abstract text is available yet for this article.
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428436/sense-and-sensibility-of-the-use-of-nt-probnp-for-eligibility-in-clinical-trials
#4
EDITORIAL
Adriaan A Voors
No abstract text is available yet for this article.
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428435/body-mass-index-and-heart-failure-mortality-more-is-less
#5
EDITORIAL
Michael E Hall
No abstract text is available yet for this article.
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428434/impact-of-body-mass-index-on-heart-failure-by-race-ethnicity-from-get-with-the-guidelines-heart-failure-gwtg-hf-registry
#6
Tiffany M Powell-Wiley, Julius Ngwa, Selomie Kebede, Di Lu, Phillip J Schulte, Deepak L Bhatt, Clyde Yancy, Gregg C Fonarow, Michelle A Albert
OBJECTIVES: This study sought to evaluate the influence of race/ethnicity on the relationship between body mass index (BMI) and mortality in heart failure with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF) patients. BACKGROUND: Prior studies demonstrated an "obesity paradox" among overweight and obese patients, where they have a better HF prognosis than normal weight patients. Less is known about the relationship between BMI and mortality among diverse patients with HF, particularly given disparities in obesity and HF prevalence...
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29331273/meta-analyses-and-interpretation-of-troponin-values-in-heart-failure
#7
EDITORIAL
Allan S Jaffe, Wayne L Miller
No abstract text is available yet for this article.
January 3, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29331272/high-sensitivity-cardiac-troponin-and-new-onset-heart-failure-a-systematic-review-and-meta-analysis-of-67-063-patients-with-4-165-incident-heart-failure-events
#8
Jonathan D W Evans, Stephen J H Dobbin, Stephen J Pettit, Emanuele Di Angelantonio, Peter Willeit
OBJECTIVES: The aim of this study was to systematically collate and appraise the available evidence regarding the association between high-sensitivity cardiac troponin (hs-cTn) and incident heart failure (HF) and the added value of hs-cTn in HF prediction. BACKGROUND: Identification of subjects at high risk for HF and early risk factor modification with medications such as angiotensin-converting enzyme inhibitors may delay the onset of HF. Hs-cTn has been suggested as a prognostic marker for the incidence of first-ever HF in asymptomatic subjects...
January 3, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226815/integrative-assessment-of-congestion-in%C3%A2-heart-failure-throughout-the-patient%C3%A2-journey
#9
REVIEW
Nicolas Girerd, Marie-France Seronde, Stefano Coiro, Tahar Chouihed, Pascal Bilbault, François Braun, David Kenizou, Bruno Maillier, Pierre Nazeyrollas, Gérard Roul, Ludivine Fillieux, William T Abraham, James Januzzi, Laurent Sebbag, Faiez Zannad, Alexandre Mebazaa, Patrick Rossignol
Congestion is one of the main predictors of poor patient outcome in patients with heart failure. However, congestion is difficult to assess, especially when symptoms are mild. Although numerous clinical scores, imaging tools, and biological tests are available to assist physicians in ascertaining and quantifying congestion, not all are appropriate for use in all stages of patient management. In recent years, multidisciplinary management in the community has become increasingly important to prevent heart failure hospitalizations...
December 6, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226820/furosemide-reimagined-novel-subcutaneous-formulation-for-a-50-year-old-loop-diuretic-agent-for-the-treatment-of-acute-decompensated-heart%C3%A2-failure
#10
EDITORIAL
Gary S Francis, Tamas Alexy
No abstract text is available yet for this article.
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226818/rate-response-programming-tailored-to%C3%A2-the-force-frequency-relationship-improves-exercise-tolerance-in-chronic-heart-failure
#11
John Gierula, Maria F Paton, Judith E Lowry, Haqeel A Jamil, Rowenna Byrom, Michael Drozd, Jack O Garnham, Richard M Cubbon, David A Cairns, Mark T Kearney, Klaus K Witte
OBJECTIVES: This study sought to examine whether the heart rate (HR) at which the force-frequency relationship (FFR) slope peaks (critical HR) could be used to tailor HR response in chronic heart failure (CHF) patients with cardiac pacemakers and whether this favorably influences exercise capacity. BACKGROUND: CHF secondary to left ventricular (LV) systolic dysfunction is characterized by blunting of the positive relationship between HR and LV contractility known as the FFR...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226817/the-twittersphere-needs-academic%C3%A2-cardiologists-heartdisease-no1killer-beyondjournals
#12
REVIEW
Sumeet Pawar, Gina Siddiqui, Nihar R Desai, Tariq Ahmad
No abstract text is available yet for this article.
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226816/efficacy-of-intravenous-furosemide-versus%C3%A2-a-novel-ph-neutral-furosemide-formulation-administered-subcutaneously%C3%A2-in-outpatients-with-worsening-heart%C3%A2-failure
#13
Nisha A Gilotra, Oluseyi Princewill, Bonnie Marino, Ike S Okwuosa, Jessica Chasler, Johana Almansa, Abby Cummings, Parker Rhodes, Julianne Chambers, Kimberly Cuomo, Stuart D Russell
OBJECTIVES: This study sought to determine the efficacy and safety of a novel, pH-neutral formulation of furosemide administered subcutaneously (SC) for treatment of acute decompensated heart failure (HF). BACKGROUND: Congestion requiring intravenous (IV) administration of a diuretic agent is the main reason patients with HF present for acute medical care. METHODS: Outpatients presenting with decompensated HF were randomized to receive a single SC or IV dose of furosemide...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226814/yet-another-important-goal-for-heart-failure-patients
#14
EDITORIAL
Marc A Silver
No abstract text is available yet for this article.
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226813/are-we-approaching-chronotropy-in-competently
#15
EDITORIAL
Brett D Atwater, Daniel J Friedman
No abstract text is available yet for this article.
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29226811/evidence-based-therapy-and-its-association-with-workforce-detachment-after-first-hospitalization-for-heart-failure
#16
Rasmus Rørth, Emil L Fosbøl, Ulrik M Mogensen, Kristian Kragholm, Pardeep S Jhund, Mark C Petrie, Morten Schou, Gunnar H Gislason, John J V McMurray, Christian Torp-Pedersen, Lars Køber, Søren L Kristensen
OBJECTIVES: This study investigated the association between the use of evidence-based medicine (EBM) for heart failure (HF) and risk of workforce detachment. BACKGROUND: The ability to work can be a marker of functional capacity and quality of life. METHODS: We examined a nationwide cohort of patients in the workforce 1 year after first hospitalization for HF. EBM was defined as treatment with β-blockers and renin angiotensin system inhibitors...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29413379/left-ventricular-dysfunction-in-cancer%C3%A2-treatment-is-it-relevant
#17
REVIEW
Benjamin Kenigsberg, Anton Wellstein, Ana Barac
Contemporary cancer therapies have dramatically improved cancer-free and overall survival but have been accompanied by increasing cancer treatment-related cardiovascular toxicity, including left ventricular (LV) systolic dysfunction. Previously, systemic chemotherapy with anthracyclines and radiation therapy were the only cancer treatments with significant cardiotoxicity. However, modern targeted cancer therapies, including HER2 inhibitors, tyrosine kinase inhibitors (TKIs), proteasome inhibitors, and immune checkpoint inhibitors, have all been associated with adverse cardiovascular events...
February 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29413378/reply-vildagliptin-and-ventricular-function-in-patients-with-type-2-diabetes-mellitus-and-heart-failure-one-step-forward
#18
LETTER
John J V McMurray
No abstract text is available yet for this article.
February 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29413377/growth-differentiation-factor-15-in-chronic-heart%C3%A2-failure-the-role-of-mirnas-regulation-and-of-wnt-signaling-modulation
#19
LETTER
Salvatore Patanè
No abstract text is available yet for this article.
February 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29413376/vildagliptin-on-ventricular-function-in-patients-with-type-2-diabetes-mellitus-and-heart-failure-one-step-forward
#20
LETTER
Venu Gopal Jonnalagadda, Kanchan Choudhary, Vijay Kranti Matety
No abstract text is available yet for this article.
February 2018: JACC. Heart Failure
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