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Journal of Allergy and Clinical Immunology in Practice

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https://www.readbyqxmd.com/read/28202405/urinary-leukotriene-e4-to-determine-aspirin-intolerance-in-asthma-a-systematic-review-and-meta-analysis
#1
John B Hagan, Tanya M Laidlaw, Rohit Divekar, Erin K O'Brien, Hirohito Kita, Gerald W Volcheck, Christina R Hagan, Devyani Lal, Harry G Teaford, Patricia J Erwin, Nan Zhang, Matthew A Rank
BACKGROUND: Urinary leukotriene E4 (ULTE4) may be a biomarker that distinguishes aspirin-intolerant asthma from other asthma subtypes. OBJECTIVE: To estimate the diagnostic testing accuracy of ULTE4 as a marker of aspirin intolerance in patients with asthma using previously published studies. METHODS: We identified relevant clinical studies from a systematic review of English and non-English articles using MEDLINE, EMBASE, and CENTRAL (inception to February 10, 2015)...
February 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28202404/recombinant-human-c1-esterase-inhibitor-to-treat-acute-hereditary-angioedema-attacks-in-adolescents
#2
James W Baker, Avner Reshef, Dumitru Moldovan, Joseph R Harper, Anurag Relan, Marc A Riedl
BACKGROUND: Recombinant human C1-esterase inhibitor (rhC1-INH) is efficacious and well tolerated for managing hereditary angioedema (HAE) attacks in adults. However, there are insufficient data on its efficacy and safety in adolescents. OBJECTIVE: To evaluate the efficacy and safety profiles of rhC1-INH for acute HAE attacks in adolescents. METHODS: Adolescents (aged 12-18 y) with HAE enrolled in 2 randomized controlled trials and 2 open-label extension trials were included and received intravenous rhC1-INH for acute attacks...
February 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28189630/characterization-of-vancomycin-reactions-and-linezolid-utilization-in-the-pediatric-population
#3
Samantha K Lin, Kevin M Mulieri, Faoud T Ishmael
BACKGROUND: Red man syndrome (RMS) occurs because of non-IgE-mediated histamine release. Unlike vancomycin allergy, which necessitates the use of an alternative drug (often linezolid), RMS does not typically preclude further vancomycin use. Care should be taken to differentiate these reaction types from one another to prevent unnecessary vancomycin avoidance. OBJECTIVE: To characterize vancomycin reaction types in our population, and to determine whether having a reaction consistent with RMS is associated with otherwise unexplained vancomycin avoidance and linezolid use...
February 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28174014/antibiotic-use-in-early-life-rural-residence-and-allergic-diseases-in-argentinean-children
#4
Yueh-Ying Han, Erick Forno, Héctor A Badellino, Juan C Celedón
BACKGROUND: Little is known about differential effects of antibiotic use on allergic diseases in rural versus urban environments. OBJECTIVE: To examine whether area of residence in the first year of life modifies the relation between antibiotic use in early life and allergic diseases during childhood. METHODS: Cross-sectional study of allergic diseases in 1517 children (ages 6-7 years) attending 101 schools in urban and rural areas of San Francisco (Córdoba, Argentina)...
February 4, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28163029/airway-hyperresponsiveness-in-asthma-measurement-and-clinical-relevance
#5
REVIEW
Parameswaran Nair, James G Martin, Donald C Cockcroft, Myrna Dolovich, Catherine Lemiere, Louis-Philippe Boulet, Paul M O'Byrne
Airway hyperresponsiveness is a characteristic feature of asthma, and its measurement is an important tool in its diagnosis. With a few caveats, methacholine bronchial provocation by a 2-minute tidal breathing method is highly sensitive; a negative test result (PC20 > 16 mg/mL, PD20 > 400 μg) rules out current asthma with reasonable certainty. A PC20 value of less than 1 mg/mL/PD20 value of less than 25 μg is highly specific (ie, diagnostic) but quite insensitive for asthma. For accurate interpretation of the test results, it is important to control and standardize technical factors that have an impact on nebulizer performance...
February 2, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28153713/a-delayed-reaction-to-the-magnetic-resonance-imaging-contrast-agent-gadobutrol
#6
Hiroshi Nagai, Chikako Nishigori
No abstract text is available yet for this article.
January 30, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28143692/the-journal-of-allergy-and-clinical-immunology-in-practice-2016-year-in-review
#7
REVIEW
Michael Schatz, Scott H Sicherer, Robert S Zeiger
As editors, we concluded that it would be helpful to our readers to write a Year in Review article that highlights the Review, Original, and Clinical Communication articles published in 2016 in The Journal of Allergy and Clinical Immunology: In Practice. We summarized articles on the topics of asthma, rhinitis/rhinosinusitis, food allergy, anaphylaxis, drug allergy, urticarial/angioedema, eosinophilic disorders, and immunodeficiency. Within each topic, epidemiologic findings are presented, relevant aspects of prevention are described, and diagnostic and therapeutic advances are enumerated...
January 28, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28143691/changing-paradigms-in-the-treatment-of-severe-asthma-the-role-of-biologic-therapies
#8
Rohit K Katial, Greg W Bensch, William W Busse, Bradley E Chipps, Joshua L Denson, Anthony N Gerber, Joshua S Jacobs, Monica Kraft, Richard J Martin, Parameswaran Nair, Michael E Wechsler
Cytokine antagonists are monoclonal antibodies that offer new treatment options for refractory asthma but will also increase complexity because they are effective only for patients with certain asthma subtypes that remain to be more clearly defined. The clinical and inflammatory heterogeneity within refractory asthma makes it difficult to manage the disease and to determine which, if any, biologic therapy is suitable for a specific patient. The purpose of this article is to provide a data-driven discussion to clarify the use of biologic therapies in patients with refractory asthma...
January 28, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28132800/preparation-and-analysis-of-peanut-flour-used-in-oral-immunotherapy-clinical-trials
#9
Jelena P Berglund, Nicole Szczepanski, Anusha Penumarti, Ayeshia Beavers, Janelle Kesselring, Kelly Orgel, Bruce Burnett, A Wesley Burks, Michael Kulis
BACKGROUND: Oral immunotherapy (OIT) is an investigational therapeutic approach for the treatment of food allergies. Characterization of the drug product used in oral immunotherapy trials for peanut allergy has not been reported. OBJECTIVE: To quantify relative amounts of the major peanut allergens and microbial load present in peanut flour used in OIT trials and assess whether these parameters change over a 12-month period. We also anticipate that this report will serve as a guide for investigators seeking to conduct OIT trials under Food and Drug Administration-approved Investigational New Drug applications...
January 26, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28132799/food-allergy-related-risk-taking-and-management-behaviors-among-adolescents-and-young-adults
#10
Christopher M Warren, Ashley A Dyer, Alana K Otto, Bridget M Smith, Kristen Kauke, Chitra Dinakar, Ruchi S Gupta
BACKGROUND: Food allergy (FA) affects 8% of children and adolescents in the United States. Nearly 40% of those affected have experienced severe reactions. Fatal food-induced anaphylaxis is most common among adolescents and young adults (AYA); however, FA-related risk behaviors persist in this population and factors associated with these behaviors remain unclear. OBJECTIVE: To characterize FA-related risk-taking and self-management behaviors of AYA with FA. METHODS: A cross-sectional survey was administered to 200 AYA with FA...
January 26, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28132798/the-clinical-significance-of-specific-antibody-deficiency-sad-severity-in-chronic-rhinosinusitis-crs
#11
Anjeni Keswani, Neha M Dunn, Angelica Manzur, Sara Kashani, Xavier Bossuyt, Leslie C Grammer, David B Conley, Bruce K Tan, Robert C Kern, Robert P Schleimer, Anju T Peters
BACKGROUND: Despite the increased identification of specific antibody deficiency (SAD) in chronic rhinosinusitis (CRS), little is known about the relationship between SAD severity and the severity and comorbidities of CRS. The prevalence of an impaired antibody response in the general population is also unknown. OBJECTIVE: The objective of this study was to determine if the SAD severity stratification applies to real-life data of patients with CRS. METHODS: An electronic health record database was used to identify patients with CRS evaluated for humoral immunodeficiency with quantitative immunoglobulins and Streptococcus pneumoniae antibody titers before and after pneumococcal vaccine...
January 26, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28132797/successful-beef-desensitization-in-2-adult-patients-with-a-delayed-type-reaction-to-red-meat
#12
Derya Unal, Raif Coskun, Semra Demir, Asli Gelincik, Bahauddin Colakoglu, Suna Buyukozturk
No abstract text is available yet for this article.
January 26, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28117272/aspirin-tolerance-in-patients-with-nonsteroidal-anti-inflammatory-drug-exacerbated-respiratory-disease-following-treatment-with-omalizumab
#13
Elsa Phillips-Angles, Pilar Barranco, Magdalena Lluch-Bernal, Javier Dominguez-Ortega, Valentín López-Carrasco, Santiago Quirce
No abstract text is available yet for this article.
January 20, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28117271/practical-quality-improvement-for-the-allergist-immunologist
#14
REVIEW
David W Price, David M Lang
Quality improvement (QI) has long been part of organized medicine, but has become increasingly more important in the last few years. Clinical expertise and input into QI activities are critical to keep QI grounded in evidence and practice. Busy clinicians face many competing demands; practical strategies are needed to help busy clinicians successfully engage in QI. This article provides a brief history of QI in medicine, notes several commonly used frameworks for QI in health care, and presents a practical QI model that can be applied to the clinical practice of allergy and immunology...
January 20, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28117270/food-allergic-adolescents-at-risk-for-anaphylaxis-a-randomized-controlled-study-of-supervised-injection-to-improve-comfort-with-epinephrine-self-injection
#15
Eyal Shemesh, Christine D'Urso, Christopher Knight, Melissa Rubes, Kinga M Picerno, Ailie M Posillico, Zara Atal, Rachel A Annunziato, Scott H Sicherer
BACKGROUND: Epinephrine self-injection is a key element in the management of food allergy, yet many adolescents report that they may not be able to use the autoinjector when needed. We hypothesized that supervised self-injection with an empty syringe would increase adolescents' comfort with self-injection. OBJECTIVE: The objective of this study was to examine the effect of supervised self-injection on self- and parent-reported comfort and anxiety during and after clinic visits in a food allergy center...
January 20, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28117269/anaphylaxis-to-tranexamic-acid-a-rare-reaction-to-a-common-drug
#16
Philip H Li, Cecilia Trigg, Ryszard Rutkowski, Krzysztof Rutkowski
No abstract text is available yet for this article.
January 20, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28110058/threshold-dose-distribution-in-walnut-allergy
#17
Mark A Blankestijn, Ben C Remington, Geert F Houben, Joe L Baumert, André C Knulst, W Marty Blom, Rob J B Klemans, Steve L Taylor
BACKGROUND: In food allergy, eliciting doses (EDs) of foods on a population level can improve risk management and labeling strategies for the food industry and regulatory authorities. Previously, data available for walnut were unsuitable to determine EDs. OBJECTIVE: The objective of this study was to determine EDs for walnut allergic adults and to compare with previously established threshold data for peanut and tree nuts. METHODS: Prospectively, adult subjects with a suspected walnut allergy underwent a low-dose double-blind, placebo-controlled food challenge...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28110057/real-life-outcomes-for-patients-with-asthma-prescribed-spacers-for-use-with-either-extrafine-or-fine-particle-inhaled-corticosteroids
#18
Theresa W Guilbert, Gene Colice, Jonathan Grigg, Wim van Aalderen, Richard J Martin, Elliot Israel, Dirkje S Postma, Nicolas Roche, Wanda Phipatanakul, Elizabeth V Hillyer, Jennifer M Evans, Myrna B Dolovich, David B Price
BACKGROUND: Spacers are often used with pressurized metered-dose inhalers (pMDIs) to eliminate the need for coordinating inhalation with actuation. OBJECTIVE: To investigate the real-life effectiveness of spacers prescribed for use with either extrafine- or fine-particle inhaled corticosteroids (ICSs). METHODS: This historical matched cohort study examined anonymous medical record data over 2 years (1-year baseline, 1-year outcome) for patients with asthma aged 12 to 80 years initiating ICSs by pMDI with or without prescribed spacer...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28110056/current-knowledge-and-management-of-hypersensitivity-reactions-to-monoclonal-antibodies
#19
Matthieu Picard, Violeta Régnier Galvão
Hypersensitivity reactions (HSRs) to monoclonal antibodies (mAbs) are increasingly frequent as this class of therapeutic agents is rapidly expanding. Immediate and nonimmediate HSRs have been reported with mAbs. Immediate HSRs can be explained by 3 main mechanisms: cytokine release syndrome, IgE-mediated, and IgG-mediated reactions. Importantly, IgE-mediated reactions can occur on first exposure due to preformed specific IgEs, as shown for cetuximab. Almost all patients with an immediate HSR can be safely re-exposed either through desensitization or challenge depending on the severity and mechanism of the initial reaction...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28110055/adverse-and-hypersensitivity-reactions-to-prescription-nonsteroidal-anti-inflammatory-agents-in-a-large-health-care-system
#20
Kimberly G Blumenthal, Kenneth H Lai, Mingshu Huang, Zachary S Wallace, Paige G Wickner, Li Zhou
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used medications in the United States. NSAID use can be limited by adverse drug reactions (ADRs), including hypersensitivity reactions (HSRs). OBJECTIVE: We aimed to use electronic health record data to determine the incidence and predictors of HSRs to prescription NSAIDs. METHODS: We performed a retrospective cohort study of all adult outpatients in a large health care system prescribed diclofenac, indomethacin, nabumetone, or piroxicam between January 1, 2004, and September 30, 2012...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
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