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Journal of Allergy and Clinical Immunology in Practice

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https://www.readbyqxmd.com/read/29684579/age-and-gender-associations-with-systemic-corticosteroid-induced-morbidity-in-asthma
#1
Luke E Barry, Ciaran O'Neill, Chris Patterson, Joan Sweeney, David Price, Liam G Heaney
BACKGROUND: Treatment of severe asthma may include high dose systemic-corticosteroid therapy which is associated with substantial comorbidity. There is evidence to suggest that this burden is not evenly distributed across age, gender and corticosteroid exposure levels. OBJECTIVE: Examine the associations between age, gender, comorbidity, and patterns of healthcare cost across groups differentiated by corticosteroid exposure. METHODS: Patients with severe asthma (n=808) were matched by age and gender to patients with mild/moderate asthma (n=3,975) and non-asthma control subjects (n=2,412) from the Optimum Patient Care Research Database (OPCRD)...
April 20, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29684578/exposure-and-sensitization-to-pets-modify-endotoxin-association-with-asthma-and-wheeze
#2
Angelico Mendy, Jesse Wilkerson, Pӓivi M Salo, Richard D Cohn, Darryl C Zeldin, Peter S Thorne
BACKGROUND: Pets are major contributors of endotoxin in homes, but whether they influence endotoxin association with respiratory outcomes is unclear. OBJECTIVE: To examine whether exposure and sensitization to dog and cat modify the relationship between endotoxin exposure and asthma and wheeze. METHODS: We analyzed data from 6,051 participants in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). House dust from bedroom floor and bedding was evaluated for endotoxin and for dog (Canis familiaris 1) and cat (Feline domesticus 1) allergens...
April 20, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29660429/summary-and-simulation-of-reported-adverse-events-from-epinephrine-autoinjectors-and-a-review-of-the-literature
#3
Marcus Shaker, Dana Toy, Christopher Lindholm, Jeffrey Low, Erin Reigh, Matthew Greenhawt
No abstract text is available yet for this article.
April 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29660428/the-kinetics-of-anti-drug-antibodies-drug-levels-and-clinical-outcomes-in-infliximab-exposed-patients-with-immuno-mediated-disorders
#4
Nencini Francesca, Vultaggio Alessandra, Pratesi Sara, Cammelli Daniele, Milla Monica, Fiori Ginevra, Bagnoli Siro, Prignano Francesca, Romagnani Sergio, Maggi Enrico, Matucci Andrea
BACKGROUND: Hypersensitivity reactions (HRs) and loss of response (LOR) to infliximab (IFX) are related to drug immunogenicity characterized by anti-drug antibodies (ADA). OBJECTIVE: To analyse the timing of ADA appearance, and its relationship with drug levels and clinical outcomes in IFX-treated patients with different diseases. METHODS: Samples were longitudinally collected before each infusion from 91 IFX-treated patients and were assayed for ADA and drug levels by ELISA and for IgE by CAP-system Clinical data were also monitored, regarding efficacy and safety of therapy...
April 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29655774/twenty-years-experience-with-anaphylaxis-like-reactions-to-local-anesthetics-genuine-allergy-is-rare
#5
Axel Trautmann, Matthias Goebeler, Johanna Stoevesandt
BACKGROUND: Anaphylaxis-like reactions occur within minutes after application of local anesthetics (LA), most commonly during dental interventions. Impressive symptoms including respiratory distress or loss of consciousness frequently give rise to a suspicion of allergy and may prompt patients and treating physicians to refuse future LA injections. OBJECTIVE: Non-allergic mechanisms are responsible for the majority of LA-induced immediate-type reactions. In view of the preponderance of non-allergic reactions, the question arises whether genuine LA allergy may be missed during routine testing procedures...
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29655773/successful-rapid-oral-clindamycin-desensitization-in-a-pediatric-patient
#6
Brittany E Esty, Samantha Minnicozzi, Esther Chang Chu, Ana Dioun Broyles, Christina S K Yee
No abstract text is available yet for this article.
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29655772/predicting-chronic-spontaneous-urticaria-symptom-return-after-omalizumab-treatment-discontinuation-exploratory-analysis
#7
Marta Ferrer, Ana Giménez-Arnau, Diego Saldana, Nico Janssens, Maria-Magdalena Balp, Sam Khalil, Valéry Risson
BACKGROUND: Omalizumab is highly effective in controlling chronic spontaneous urticaria (CSU) symptoms; however, patients can experience symptom return upon treatment discontinuation. Pivotal clinical trials have identified two categories of patients who experience symptom return: rapid and slow. OBJECTIVE: To identify potential predictors of the speed of symptom return after stopping omalizumab treatment. METHODS: Phase III randomized controlled trial (RCT) data from ASTERIA I (n=319; 6x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01287117) and ASTERIA II (n=323; 3x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01292473) were pooled to identify predictors of symptom return after stopping omalizumab treatment (16-week follow-up)...
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29655771/iodinated-contrast-media-allergy-in-patients-hospitalized-for-investigation-of-chest-pain
#8
Guy Topaz, Adi Karas, Nuha Kassem, Yona Kitay-Cohen, David Pereg, Lotan Shilo, Adi Zoref-Lorenz, Alon Y Hershko
BACKGROUND: Iodinated contrast media (ICM) allergy may entail severe adverse events in patients who undergo percutaneous coronary intervention (PCI). Premedication protocols and low-osmolality contrast media have been thought to improve the outcomes of these individuals. OBJECTIVE: To assess the prevalence and severity of allergic reactions during PCI in patients admitted for investigation of chest pain. METHODS: This is a retrospective analysis of 13,652 patients who were hospitalized with chest pain during the years 2010-2016, at the Department of Internal Medicine, Meir Medical Center...
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29653219/anaphylaxis-knowledge-in-camp-personnel
#9
Margaret Redmond, Michael Pistiner, Rebecca Scherzer, David Stukus, Frank J Twarog, John Lee
No abstract text is available yet for this article.
April 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29653218/comparing-ran-out-status-of-inhaled-short-acting-beta-agonists-in-emergency-department-patients-with-acute-asthma-1996-1998-versus-2015-2017
#10
Tadahiro Goto, Carlos A Camargo, Catalina Gimenez-Zapiola, Daniel J Pallin, Nathan I Shapiro, Thomas J Ferro, Carolyn Rainville, Stanislav Stoyanov, Kohei Hasegawa
BACKGROUND: Medication non-adherence including running out of inhaled asthma medications, is an important problem. OBJECTIVE: To examine the changes in the proportion of adults with acute asthma who ran out of their short-acting beta-agonist (SABA) inhalers before presenting to the emergency department (ED) between 1996-1998 and 2015-2017. METHODS: We analyzed data from prospective multicenter observational cohort studies of ED adult patients (aged 18-54 years) with acute asthma...
April 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29627457/relationship-of-inhaled-corticosteroid-adherence-to-asthma-exacerbations-in-patients-with-moderate-to-severe-asthma
#11
Alberto Papi, Dermot Ryan, Joan B Soriano, Henry Chrystyn, Leif Bjermer, Roberto Rodríguez-Roisin, Myrna B Dolovich, Mark Harris, Lucy Wood, Maria Batsiou, Susannah I Thornhill, David B Price
BACKGROUND: Patients with asthma and elevated blood eosinophils are at increased risk of severe exacerbations. Management of these patients should consider non-adherence to inhaled corticosteroid (ICS) therapy as a factor for increased exacerbation risk. OBJECTIVE: To investigate whether poor adherence to ICS therapy explains the occurrence of asthma exacerbations in patients with elevated blood eosinophil levels. METHODS: This historical cohort study identified patients within the Optimum Patient Care Research Database, aged ≥18 years, at Global Initiative for Asthma (GINA) steps 3 or 4, with ≥2 ICS prescriptions during the year prior to clinical review...
April 5, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29626637/intraoperative-anaphylaxis-secondary-to-systemic-cooling-in-a-pediatric-patient-with-cold-induced-urticaria
#12
Michelle C Maciag, Charles Nargozian, Ana Dioun Broyles
No abstract text is available yet for this article.
April 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29626636/occupational-exposures-and-asthma-prevalence-among-us-farmworkers-national-agricultural-workers-survey-2003-2014
#13
Anna J Chen Arroyo, Lacey B Robinson, N Lance Downing, Carlos A Camargo
No abstract text is available yet for this article.
April 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29614326/follicular-traction-urticaria
#14
Shiven S Patel, Richard F Lockey
No abstract text is available yet for this article.
March 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29609049/type-2-biomarkers-and-prediction-of-future-exacerbations-and-lung-function-decline-in-adult-asthma
#15
Ruth Semprini, Mathew Williams, Alex Semprini, Alice McDouall, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene Braithwaite
BACKGROUND: Type 2 biomarkers that predict both likelihood of future severe exacerbations and response to monoclonal antibody therapy in asthma, would be useful clinically in identifying patients both at greater risk of hospitalization, and most likely to benefit from monoclonal antibody therapy. OBJECTIVE: To describe the association between the Type 2 biomarkers, blood eosinophils, FeNO, serum periostin, serum IgE and time to severe exacerbation in a broad asthma population...
March 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29609048/use-of-immunology-and-immunodeficiency-topics-in-uptodate
#16
E Richard Stiehm, Elizabeth C Tepas, Anna M Feldweg
No abstract text is available yet for this article.
March 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29606638/epinephrine-in-severe-allergic-reactions-the-european-anaphylaxis-register
#17
Linus B Grabenhenrich, Sabine Dölle, Franziska Ruëff, Jean-Marie Renaudin, Kathrin Scherer, Claudia Pföhler, Regina Treudler, Alice Koehli, Vera Mahler, Thomas Spindler, Lars Lange, Maria Beatrice Bilò, Nikolaos G Papadopoulos, Jonathan O B Hourihane, Roland Lang, Montserrat Fernández-Rivas, George Christoff, Ewa Cichocka-Jarosz, Margitta Worm
BACKGROUND: Current guidelines recommend intramuscular administration of epinephrine as the first-line drug for the emergency treatment of severe allergic reactions (anaphylaxis), but no randomized trial evidence supports this consensus. OBJECTIVE: We aimed to assess anaphylaxis treatment practices over 10 years, covering several European regions, all allergen sources, and all age groups. METHODS: The European Anaphylaxis Register tracks elicitors, symptoms, emergency treatment, diagnostic workups, and long-term counseling for anaphylaxis incidents through web-based data entry from tertiary allergy specialists, covering information from the emergency respondent, patient, tertiary referral, and laboratory/clinical test results...
March 29, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29577987/generalized-pruritus-relieved-by-nsaids-in-the-setting-of-mast-cell-activation-syndrome
#18
Katrina Kesterson, Zachary Nahmias, Jonathan R Brestoff, Nancy D Bodet, Andrew Kau, Brian S Kim
No abstract text is available yet for this article.
March 22, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29577986/prurigo-pigmentosa-an-itchy-urticarial-eruption-confused-for-food-allergy
#19
Peter Capucilli, Joy Wan, James Corry, Jennifer H Chuang, Rebecca L Linn, Marissa J Perman
No abstract text is available yet for this article.
March 22, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29574127/unusual-clinical-manifestation-of-laryngeal-edema-in-a-case-of-dress-syndrome
#20
Da Woon Sim, Young-Il Koh
No abstract text is available yet for this article.
March 21, 2018: Journal of Allergy and Clinical Immunology in Practice
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