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NeuroImage: Clinical

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https://www.readbyqxmd.com/read/29204344/mr-brain-volumetric-measurements-are-predictive-of-neurobehavioral-impairment-in-the-hiv-1-transgenic-rat
#1
Rafael Casas, Siva Muthusamy, Paul G Wakim, Sanhita Sinharay, Margaret R Lentz, William C Reid, Dima A Hammoud
Introduction: HIV infection is known to be associated with brain volume loss, even in optimally treated patients. In this study, we assessed whether dynamic brain volume changes over time are predictive of neurobehavorial performance in the HIV-1 transgenic (Tg) rat, a model of treated HIV-positive patients. Materials and methods: Cross-sectional brain MRI imaging was first performed comparing Tg and wild type (WT) rats at 3 and 19 months of age. Longitudinal MRI and neurobehavioral testing of another group of Tg and WT rats was then performed from 5 to 23 weeks of age...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29204343/episodic-memory-after-trauma-exposure-medial-temporal-lobe-function-is-positively-related-to-re-experiencing-and-inversely-related-to-negative-affect-symptoms
#2
Jennifer S Stevens, Renuka Reddy, Ye Ji Kim, Sanne J H van Rooij, Timothy D Ely, Stephan Hamann, Kerry J Ressler, Tanja Jovanovic
Hippocampal structure is particularly sensitive to trauma and other stressors. However, previous findings linking hippocampal function with trauma-related psychopathology have been mixed. Heterogeneity in psychological responses to trauma has not been considered with respect to hippocampal function and may contribute to mixed findings. To address these issues, we examined associations between data-driven symptom dimensions and episodic memory formation, a key function of the hippocampus, in a trauma-exposed sample...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29204342/sex-differences-in-white-matter-alterations-following-repetitive-subconcussive-head-impacts-in-collegiate-ice-hockey-players
#3
Nico Sollmann, Paul S Echlin, Vivian Schultz, Petra V Viher, Amanda E Lyall, Yorghos Tripodis, David Kaufmann, Elisabeth Hartl, Philipp Kinzel, Lorie A Forwell, Andrew M Johnson, Elaine N Skopelja, Christian Lepage, Sylvain Bouix, Ofer Pasternak, Alexander P Lin, Martha E Shenton, Inga K Koerte
Objective: Repetitive subconcussive head impacts (RSHI) may lead to structural, functional, and metabolic alterations of the brain. While differences between males and females have already been suggested following a concussion, whether there are sex differences following exposure to RSHI remains unknown. The aim of this study was to identify and to characterize sex differences following exposure to RSHI. Methods: Twenty-five collegiate ice hockey players (14 males and 11 females, 20...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201645/promoter-haplotypes-of-interleukin-10-gene-linked-to-cortex-plasticity-in-subjects-with-risk-of-alzheimer-s-disease
#4
Feng Bai, Chunming Xie, Yonggui Yuan, Yongmei Shi, Zhijun Zhang
The Alzheimer's disease (AD) aetiologic event is associated with brain inflammatory processes. In this study, we consider a haplotype of the IL-10 gene promoter region, - 1082A/- 819 T/- 592A (ATA haplotype), which is an additive and independent genetic risk factor for AD. Episodic memory change is the most striking cognitive alteration in AD. It remains unclear whether episodic memory networks can be affected by the ATA haplotype variant in amnestic mild cognitive impairment (aMCI), and if so, how this occurs...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201644/mean-diffusivity-in-cortical-gray-matter-in-alzheimer-s-disease-the-importance-of-partial-volume-correction
#5
Judith Henf, Michel J Grothe, Katharina Brueggen, Stefan Teipel, Martin Dyrba
Mean diffusivity (MD) measured by diffusion tensor imaging can reflect microstructural alterations of the brain's gray matter (GM). Therefore, GM MD may be a sensitive marker of neurodegeneration related to Alzheimer's Disease (AD). However, due to partial volume effects (PVE), differences in MD may be overestimated because of a higher degree of brain atrophy in AD patients and in cases with mild cognitive impairment (MCI). Here, we evaluated GM MD changes in AD and MCI compared with healthy controls, and the effect of partial volume correction (PVC) on diagnostic utility of MD...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201643/relationships-between-brain-metabolite-levels-functional-connectivity-and-negative-mood-in-urologic-chronic-pelvic-pain-syndrome-patients-compared-to-controls-a-mapp-research-network-study
#6
Daniel E Harper, Eric Ichesco, Andrew Schrepf, Megan Halvorson, Tudor Puiu, Daniel J Clauw, Richard E Harris, Steven E Harte
Until recently, the predominant pathology of chronic pelvic pain conditions was thought to reside in the peripheral tissues. However, mounting evidence from neuroimaging studies suggests an important role of the central nervous system in the pathogenesis of these conditions. In the present cross-sectional study, proton magnetic resonance spectroscopy (1H-MRS) of the brain was conducted in female patients with urologic chronic pelvic pain syndrome (UCPPS) to determine if they exhibit abnormal concentrations of brain metabolites (e...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201642/the-effect-of-duration-of-illness-and-antipsychotics-on-subcortical-volumes-in-schizophrenia-analysis-of-778-subjects
#7
Naoki Hashimoto, Yoichi M Ito, Naohiro Okada, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Noriko Kudo, Ariyoshi Takemura, Shuraku Son, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Asuka Katsuki, Kazutaka Ohi, Fumio Yamashita, Shinsuke Koike, Tsutomu Takahashi, Kiyotaka Nemoto, Masaki Fukunaga, Toshiaki Onitsuka, Yoshiyuki Watanabe, Hidenori Yamasue, Michio Suzuki, Kiyoto Kasai, Ichiro Kusumi, Ryota Hashimoto
Background: The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods: Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201641/iron-related-gene-variants-and-brain-iron-in-multiple-sclerosis-and-healthy-individuals
#8
Jesper Hagemeier, Murali Ramanathan, Ferdinand Schweser, Michael G Dwyer, Fuchun Lin, Niels Bergsland, Bianca Weinstock-Guttman, Robert Zivadinov
Brain iron homeostasis is known to be disturbed in multiple sclerosis (MS), yet little is known about the association of common gene variants linked to iron regulation and pathological tissue changes in the brain. In this study, we investigated the association of genetic determinants linked to iron regulation with deep gray matter (GM) magnetic susceptibility in both healthy controls (HC) and MS patients. Four hundred (400) patients with MS and 150 age- and sex-matched HCs were enrolled and obtained 3 T MRI examination...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201640/connectome-analysis-with-diffusion-mri-in-idiopathic-parkinson-s-disease-evaluation-using-multi-shell-multi-tissue-constrained-spherical-deconvolution
#9
Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system. In this work, we evaluated the structural connectome of patients with PD, as mapped by diffusion-weighted MRI tractography and a multi-shell, multi-tissue (MSMT) constrained spherical deconvolution (CSD) method to increase the precision of tractography at tissue interfaces. The connectome was mapped with probabilistic MSMT-CSD in 21 patients with PD and in 21 age- and gender-matched controls...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201639/visual-feedback-alters-force-control-and-functional-activity-in-the-visuomotor-network-after-stroke
#10
Derek B Archer, Nyeonju Kang, Gaurav Misra, Shannon Marble, Carolynn Patten, Stephen A Coombes
Modulating visual feedback may be a viable option to improve motor function after stroke, but the neurophysiological basis for this improvement is not clear. Visual gain can be manipulated by increasing or decreasing the spatial amplitude of an error signal. Here, we combined a unilateral visually guided grip force task with functional MRI to understand how changes in the gain of visual feedback alter brain activity in the chronic phase after stroke. Analyses focused on brain activation when force was produced by the most impaired hand of the stroke group as compared to the non-dominant hand of the control group...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201638/patterns-of-grey-matter-loss-associated-with-motor-subscores-in-early-parkinson-s-disease
#11
Xingfeng Li, Yue Xing, Antonio Martin-Bastida, Paola Piccini, Dorothee P Auer
Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associated with different anatomical patterns of neurodegeneration as reflected by brain grey matter (GM) alteration. This study aimed to investigate associations between motor subscores and brain GM at voxel level. High resolution structural MRI T1 scans from the Parkinson's Progression Markers Initiative (PPMI) repository were employed to estimate brain GM intensity of PD subjects...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159062/evaluation-of-factors-influencing-18f-fet-uptake-in-the-brain
#12
Antoine Verger, Carina Stegmayr, Norbert Galldiks, Axel Van Der Gucht, Philipp Lohmann, Gabriele Stoffels, Nadim J Shah, Gereon R Fink, Simon B Eickhoff, Eric Guedj, Karl-Josef Langen
PET using the amino-acid O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of 18F-FET uptake in various brain areas, and thus affect quantification of 18F-FET uptake in brain tumours. Negative 18F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of 18F-FET, were evaluated retrospectively...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159061/eeg-coherence-related-to-fmri-resting-state-synchrony-in-long-term-abstinent-alcoholics
#13
Valerie A Cardenas, Mathew Price, George Fein
Recent work suggests that faulty co-activation or synchrony of multiple brain regions comprising "networks," or an imbalance between opposing brain networks, is important in alcoholism. Previous studies showed higher fMRI resting state synchrony (RSS) within the executive control (inhibitory control and emotion regulation) networks and lower RSS within the appetitive drive network in long-term (multi-year) abstinent alcoholics (LTAA) vs. non substance abusing controls (NSAC). Our goal was to identify EEG networks that are correlated with the appetitive drive and executive function networks identified with fMRI in our previous alcohol studies...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159060/association-between-hippocampus-volume-and-symptom-profiles-in-obsessive-compulsive-disorder
#14
Tim Jonas Reess, Oana Georgiana Rus, Deniz A Gürsel, Benita Schmitz-Koep, Gerd Wagner, Götz Berberich, Kathrin Koch
Background: The hippocampus has recently been identified to play a key role in the pathophysiology of adult obsessive-compulsive disorder (OCD). Surprisingly, there is only limited evidence regarding the potential relationships with symptom dimensions. Due to the heterogeneity of symptoms in OCD, we aimed at further examining, whether hippocampal volume differences might be related to symptom profiles instead of single symptom dimensions. Methods: In order to find out more about the potential association between clinical symptom profiles and alterations in hippocampal volume we categorized a large sample of OCD patients (N = 66) into distinct symptom profile groups using K-means clustering...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159059/triangulation-of-language-cognitive-impairments-naming-errors-and-their-neural-bases-post-stroke
#15
Ajay D Halai, Anna M Woollams, Matthew A Lambon Ralph
In order to gain a better understanding of aphasia one must consider the complex combinations of language impairments along with the pattern of paraphasias. Despite the fact that both deficits and paraphasias feature in diagnostic criteria, most research has focused only on the lesion correlates of language deficits, with minimal attention on the pattern of patients' paraphasias. In this study, we used a data-driven approach (principal component analysis - PCA) to fuse patient impairments and their pattern of errors into one unified model of chronic post-stroke aphasia...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159058/local-and-distant-relationships-between-amyloid-tau-and-neurodegeneration-in-alzheimer-s-disease
#16
Leonardo Iaccarino, Gautam Tammewar, Nagehan Ayakta, Suzanne L Baker, Alexandre Bejanin, Adam L Boxer, Maria Luisa Gorno-Tempini, Mustafa Janabi, Joel H Kramer, Andreas Lazaris, Samuel N Lockhart, Bruce L Miller, Zachary A Miller, James P O'Neil, Rik Ossenkoppele, Howard J Rosen, Daniel R Schonhaut, William J Jagust, Gil D Rabinovici
The relationships between β-amyloid (Aβ), tau and neurodegeneration within Alzheimer's Disease pathogenesis are not fully understood. To explore these associations in vivo, we evaluated 30 Aβ PET-positive patients (mean ± sd age 62.4 ± 8.3) with mild probable AD and 12 Aβ PET-negative healthy controls (HC) (mean ± sd age 77.3 ± 6.9) as comparison. All participants underwent 3 T MRI, 11C-PiB (Aβ) PET and 18F-AV1451 (tau) PET. Multimodal correlation analyses were run at both voxel- and region-of-interest levels...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159057/gray-matter-atrophy-patterns-in-multiple-sclerosis-a-10-year-source-based-morphometry-study
#17
Niels Bergsland, Dana Horakova, Michael G Dwyer, Tomas Uher, Manuela Vaneckova, Michaela Tyblova, Zdenek Seidl, Jan Krasensky, Eva Havrdova, Robert Zivadinov
Objectives: To investigate spatial patterns of gray matter (GM) atrophy and their association with disability progression in patients with early relapsing-remitting multiple sclerosis (MS) in a longitudinal setting. Methods: Brain MRI and clinical neurological assessments were obtained in 152 MS patients at baseline and after 10 years of follow-up. Patients were classified into those with confirmed disability progression (CDP) (n = 85) and those without CDP (n = 67) at the end of the study...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159056/no-association-of-cortical-amyloid-load-and-eeg-connectivity-in-older-people-with-subjective-memory-complaints
#18
Stefan Teipel, Hovagim Bakardjian, Gabriel Gonzalez-Escamilla, Enrica Cavedo, Sarah Weschke, Martin Dyrba, Michel J Grothe, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Harald Hampel
Changes in functional connectivity of cortical networks have been observed in resting-state EEG studies in healthy aging as well as preclinical and clinical stages of AD. Little information, however, exists on associations between EEG connectivity and cortical amyloid load in people with subjective memory complaints. Here, we determined the association of global cortical amyloid load, as measured by florbetapir-PET, with functional connectivity based on the phase-lag index of resting state EEG data for alpha and beta frequency bands in 318 cognitively normal individuals aged 70-85 years with subjective memory complaints from the INSIGHT-preAD cohort...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159055/neural-correlates-of-working-memory-deficits-and-associations-to-response-inhibition-in-obsessive-compulsive-disorder
#19
Stephan Heinzel, Christian Kaufmann, Rosa Grützmann, Robert Hummel, Julia Klawohn, Anja Riesel, Katharina Bey, Leonhard Lennertz, Michael Wagner, Norbert Kathmann
Previous research in patients with obsessive-compulsive disorder (OCD) has indicated performance decrements in working memory (WM) and response inhibition. However, underlying neural mechanisms of WM deficits are not well understood to date, and empirical evidence for a proposed conceptual link to inhibition deficits is missing. We investigated WM performance in a numeric n-back task with four WM load conditions during functional Magnetic Resonance Imaging (fMRI) in 51 patients with OCD and 49 healthy control participants who were matched for age, sex, and education...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159054/delayed-access-to-bilateral-input-alters-cortical-organization-in-children-with-asymmetric-hearing
#20
Melissa Jane Polonenko, Blake Croll Papsin, Karen Ann Gordon
Bilateral hearing in early development protects auditory cortices from reorganizing to prefer the better ear. Yet, such protection could be disrupted by mismatched bilateral input in children with asymmetric hearing who require electric stimulation of the auditory nerve from a cochlear implant in their deaf ear and amplified acoustic sound from a hearing aid in their better ear (bimodal hearing). Cortical responses to bimodal stimulation were measured by electroencephalography in 34 bimodal users and 16 age-matched peers with normal hearing, and compared with the same measures previously reported for 28 age-matched bilateral implant users...
2018: NeuroImage: Clinical
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