journal
MENU ▼
Read by QxMD icon Read
search

NeuroImage: Clinical

journal
https://www.readbyqxmd.com/read/28616384/comparison-of-large-scale-human-brain-functional-and-anatomical-networks-in-schizophrenia
#1
Brent G Nelson, Danielle S Bassett, Jazmin Camchong, Edward T Bullmore, Kelvin O Lim
Schizophrenia is a disease with disruptions in thought, emotion, and behavior. The dysconnectivity hypothesis suggests these disruptions are due to aberrant brain connectivity. Many studies have identified connectivity differences but few have been able to unify gray and white matter findings into one model. Here we develop an extension of the Network-Based Statistic (NBS) called NBSm (Multimodal Network-based statistic) to compare functional and anatomical networks in schizophrenia. Structural, resting functional, and diffusion magnetic resonance imaging data were collected from 29 chronic patients with schizophrenia and 29 healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28616383/multiparametric-mri-to-distinguish-early-onset-alzheimer-s-disease-and-behavioural-variant-of-frontotemporal-dementia
#2
Elisa Canu, Federica Agosta, Gorana Mandic-Stojmenovic, Tanja Stojković, Elka Stefanova, Alberto Inuggi, Francesca Imperiale, Massimiliano Copetti, Vladimir S Kostic, Massimo Filippi
This prospective study explored whether an approach combining structural [cortical thickness and white matter (WM) microstructure] and resting state functional MRI can aid differentiation between 62 early onset Alzheimer's disease (EOAD) and 27 behavioural variant of frontotemporal dementia (bvFTD) patients. Random forest and receiver operator characteristic curve analyses assessed the ability of MRI in classifying the two clinical syndromes. All patients showed a distributed pattern of brain alterations relative to controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28616382/improving-language-mapping-in-clinical-fmri-through-assessment-of-grammar
#3
Monika Połczyńska, Kevin Japardi, Susan Curtiss, Teena Moody, Christopher Benjamin, Andrew Cho, Celia Vigil, Taylor Kuhn, Michael Jones, Susan Bookheimer
INTRODUCTION: Brain surgery in the language dominant hemisphere remains challenging due to unintended post-surgical language deficits, despite using pre-surgical functional magnetic resonance (fMRI) and intraoperative cortical stimulation. Moreover, patients are often recommended not to undergo surgery if the accompanying risk to language appears to be too high. While standard fMRI language mapping protocols may have relatively good predictive value at the group level, they remain sub-optimal on an individual level...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28616381/anosognosia-for-memory-deficits-in-mild-cognitive-impairment-insight-into-the-neural-mechanism-using-functional-and-molecular-imaging
#4
Patrizia Vannini, Bernard Hanseeuw, Catherine E Munro, Rebecca E Amariglio, Gad A Marshall, Dorene M Rentz, Alvaro Pascual-Leone, Keith A Johnson, Reisa A Sperling
Anosognosia, or loss of insight of memory deficits, is a common and striking symptom in Alzheimer's disease (AD). Previous findings in AD dementia patients suggest that anosognosia is due to both functional metabolic changes within cortical midline structures involved in self-referential processes, as well as functional disconnection between these regions. The present study aims to extend these findings by investigating the neural correlates of anosognosia in the prodromal stage of AD. Here, we used regional brain metabolism (resting state 18-F fluorodeoxyglucose positron emission tomography (FDG-PET)) to unravel the metabolic correlates of anosognosia in subjects with amnestic mild cognitive impairment (aMCI) and subsequently resting state functional magnetic resonance imaging (rs-fMRI) to investigate the intrinsic connectivity disruption between brain regions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28603687/prematurity-and-brain-perfusion-arterial-spin-labeling-mri
#5
Domenico Tortora, Peter Angelo Mattei, Riccardo Navarra, Valentina Panara, Rita Salomone, Andrea Rossi, John A Detre, Massimo Caulo
PURPOSE: Abnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions (PNp) and term neonates with normal MRI (TN). The correlation between CBF and clinical outcome was explored. MATERIALS AND METHODS: The institutional review board approved this prospective study and waived informed consent...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28580296/cortical-gyrification-is-abnormal-in-children-with-prenatal-alcohol-exposure
#6
Timothy J Hendrickson, Bryon A Mueller, Elizabeth R Sowell, Sarah N Mattson, Claire D Coles, Julie A Kable, Kenneth L Jones, Christopher J Boys, Kelvin O Lim, Edward P Riley, Jeffrey R Wozniak
OBJECTIVES: Prenatal alcohol exposure (PAE) adversely affects early brain development. Previous studies have shown a wide range of structural and functional abnormalities in children and adolescents with PAE. The current study adds to the existing literature specifically on cortical development by examining cortical gyrification in a large sample of children with PAE compared to controls. Relationships between cortical development and intellectual functioning are also examined. EXPERIMENTAL DESIGN: Included were 92 children with PAE and 83 controls ages 9-16 from four sites in the Collaborative Initiative on FASD (CIFASD)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28580295/regional-brain-network-organization-distinguishes-the-combined-and-inattentive-subtypes-of-attention-deficit-hyperactivity-disorder
#7
Jacqueline F Saad, Kristi R Griffiths, Michael R Kohn, Simon Clarke, Leanne M Williams, Mayuresh S Korgaonkar
Attention Deficit Hyperactivity Disorder (ADHD) is characterized clinically by hyperactive/impulsive and/or inattentive symptoms which determine diagnostic subtypes as Predominantly Hyperactive-Impulsive (ADHD-HI), Predominantly Inattentive (ADHD-I), and Combined (ADHD-C). Neuroanatomically though we do not yet know if these clinical subtypes reflect distinct aberrations in underlying brain organization. We imaged 34 ADHD participants defined using DSM-IV criteria as ADHD-I (n = 16) or as ADHD-C (n = 18) and 28 matched typically developing controls, aged 8-17 years, using high-resolution T1 MRI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28580294/gender-differences-in-the-structural-connectome-of-the-teenage-brain-revealed-by-generalized-q-sampling-mri
#8
Yeu-Sheng Tyan, Jan-Ray Liao, Chao-Yu Shen, Yu-Chieh Lin, Jun-Cheng Weng
The question of whether there are biological differences between male and female brains is a fraught one, and political positions and prior expectations seem to have a strong influence on the interpretation of scientific data in this field. This question is relevant to issues of gender differences in the prevalence of psychiatric conditions, including autism, attention deficit hyperactivity disorder (ADHD), Tourette's syndrome, schizophrenia, dyslexia, depression, and eating disorders. Understanding how gender influences vulnerability to these conditions is significant...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28580293/acupuncture-modulates-the-abnormal-brainstem-activity-in-migraine-without-aura-patients
#9
Zhengjie Li, Fang Zeng, Tao Yin, Lei Lan, Nikos Makris, Kristen Jorgenson, Taipin Guo, Feng Wu, Yujie Gao, Mingkai Dong, Mailan Liu, Jie Yang, Ying Li, Qiyong Gong, Fanrong Liang, Jian Kong
Migraine is a common neurological disease with a high prevalence and unsatisfactory treatment options. The specific pathophysiological mechanisms of migraine remain unclear, which restricts the development of effective treatments for this prevalent disorder. The aims of this study were to 1) compare the spontaneous brain activity differences between Migraine without Aura (MwoA) patients and healthy controls (HCs), using amplitude of low-frequency fluctuations (ALFF) calculation method, and 2) explore how an effective treatment (verum acupuncture) could modulate the ALFF of MwoA patients...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28580292/non-invasive-multimodal-analysis-of-cortical-activity-blood-volume-and-neurovascular-coupling-in-infantile-spasms-using-eeg-fnirs-monitoring
#10
Emilie Bourel-Ponchel, Mahdi Mahmoudzadeh, Aline Delignières, Patrick Berquin, Fabrice Wallois
Although infantile spasms can be caused by a variety of etiologies, the clinical features are stereotypical. The neuronal and vascular mechanisms that contribute to the emergence of infantile spasms are not well understood. We performed a multimodal study by simultaneously recording electroencephalogram and functional Near-infrared spectroscopy in an intentionally heterogeneous population of six children with spasms in clusters. Regardless of the etiology, spasms were accompanied by two phases of hemodynamic changes; an initial change in the cerebral blood volume (simultaneously with each spasm) followed by a neurovascular coupling in all children except for the one with a large porencephalic cyst...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560160/application-of-calibrated-fmri-in-alzheimer-s-disease
#11
Isabelle Lajoie, Scott Nugent, Clément Debacker, Kenneth Dyson, Felipe B Tancredi, AmanPreet Badhwar, Sylvie Belleville, Yan Deschaintre, Pierre Bellec, Julien Doyon, Christian Bocti, Serge Gauthier, Douglas Arnold, Marie-Jeanne Kergoat, Howard Chertkow, Oury Monchi, Richard D Hoge
Calibrated fMRI based on arterial spin-labeling (ASL) and blood oxygen-dependent contrast (BOLD), combined with periods of hypercapnia and hyperoxia, can provide information on cerebrovascular reactivity (CVR), resting blood flow (CBF), oxygen extraction fraction (OEF), and resting oxidative metabolism (CMRO2). Vascular and metabolic integrity are believed to be affected in Alzheimer's disease (AD), thus, the use of calibrated fMRI in AD may help understand the disease and monitor therapeutic responses in future clinical trials...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560159/williams-syndrome-specific-neuroanatomical-profile-and-its-associations-with-behavioral-features
#12
Chun Chieh Fan, Timothy T Brown, Hauke Bartsch, Joshua M Kuperman, Donald J Hagler, Andrew Schork, Yvonne Searcy, Ursula Bellugi, Eric Halgren, Anders M Dale
Williams Syndrome (WS) is a rare genetic disorder with unique behavioral features. Yet the rareness of WS has limited the number and type of studies that can be conducted in which inferences are made about how neuroanatomical abnormalities mediate behaviors. In this study, we extracted a WS-specific neuroanatomical profile from structural magnetic resonance imaging (MRI) measurements and tested its association with behavioral features of WS. Using a WS adult cohort (22 WS, 16 healthy controls), we modeled a sparse representation of a WS-specific neuroanatomical profile...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560158/application-and-evaluation-of-noddi-in-the-cervical-spinal-cord-of-multiple-sclerosis-patients
#13
Samantha By, Junzhong Xu, Bailey A Box, Francesca R Bagnato, Seth A Smith
INTRODUCTION: There is a need to develop imaging methods sensitive to axonal injury in multiple sclerosis (MS), given the prominent impact of axonal pathology on disability and outcome. Advanced multi-compartmental diffusion models offer novel indices sensitive to white matter microstructure. One such model, neurite orientation dispersion and density imaging (NODDI), is sensitive to neurite morphology, providing indices of apparent volume fractions of axons (vin), isotropic water (viso) and the dispersion of fibers about a central axis (orientation dispersion index, ODI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560157/optimized-classification-of-18-f-florbetaben-pet-scans-as-positive-and-negative-using-an-suvr-quantitative-approach-and-comparison-to-visual-assessment
#14
Santiago Bullich, John Seibyl, Ana M Catafau, Aleksandar Jovalekic, Norman Koglin, Henryk Barthel, Osama Sabri, Susan De Santi
INTRODUCTION: Standardized uptake value ratios (SUVRs) calculated from cerebral cortical areas can be used to categorize (18)F-Florbetaben (FBB) PET scans by applying appropriate cutoffs. The objective of this work was first to generate FBB SUVR cutoffs using visual assessment (VA) as standard of truth (SoT) for a number of reference regions (RR) (cerebellar gray matter (GCER), whole cerebellum (WCER), pons (PONS), and subcortical white matter (SWM)). Secondly, to validate the FBB PET scan categorization performed by SUVR cutoffs against the categorization made by post-mortem histopathological confirmation of the Aβ presence...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560156/neural-signature-of-coma-revealed-by-posteromedial-cortex-connection-density-analysis
#15
Briguita Malagurski, Patrice Péran, Benjamine Sarton, Beatrice Riu, Leslie Gonzalez, Fanny Vardon-Bounes, Thierry Seguin, Thomas Geeraerts, Olivier Fourcade, Francesco de Pasquale, Stein Silva
Posteromedial cortex (PMC) is a highly segregated and dynamic core, which appears to play a critical role in internally/externally directed cognitive processes, including conscious awareness. Nevertheless, neuroimaging studies on acquired disorders of consciousness, have traditionally explored PMC as a homogenous and indivisible structure. We suggest that a fine-grained description of intrinsic PMC topology during coma, could expand our understanding about how this cortical hub contributes to consciousness generation and maintain, and could permit the identification of specific markers related to brain injury mechanism and useful for neurological prognostication...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560155/grey-matter-abnormalities-in-children-and-adolescents-with-functional-neurological-symptom-disorder
#16
Kasia Kozlowska, Kristi R Griffiths, Sheryl L Foster, James Linton, Leanne M Williams, Mayuresh S Korgaonkar
OBJECTIVE: Functional neurological symptom disorder refers to the presence of neurological symptoms not explained by neurological disease. Although this disorder is presumed to reflect abnormal function of the brain, recent studies in adults show neuroanatomical abnormalities in brain structure. These structural brain abnormalities have been presumed to reflect long-term adaptations to the disorder, and it is unknown whether child and adolescent patients, with illness that is typically of shorter duration, show similar deficits or have normal brain structure...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560154/children-with-cerebral-palsy-have-altered-oscillatory-activity-in-the-motor-and-visual-cortices-during-a-knee-motor-task
#17
Max J Kurz, Amy L Proskovec, James E Gehringer, Elizabeth Heinrichs-Graham, Tony W Wilson
The neuroimaging literature on cerebral palsy (CP) has predominantly focused on identifying structural aberrations within the white matter (e.g., fiber track integrity), with very few studies examining neural activity within the key networks that serve the production of motor actions. The current investigation used high-density magnetoencephalography to begin to fill this knowledge gap by quantifying the temporal dynamics of the alpha and beta cortical oscillations in children with CP (age = 15.5 ± 3 years; GMFCS levels II-III) and typically developing (TD) children (age = 14...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560153/sexual-dimorphism-of-volume-reduction-but-not-cognitive-deficit-in-fetal-alcohol-spectrum-disorders-a-combined-diffusion-tensor-imaging-cortical-thickness-and-brain-volume-study
#18
Sarah Treit, Zhang Chen, Dongming Zhou, Lauren Baugh, Carmen Rasmussen, Gail Andrew, Jacqueline Pei, Christian Beaulieu
Quantitative magnetic resonance imaging (MRI) has revealed abnormalities in brain volumes, cortical thickness and white matter microstructure in fetal alcohol spectrum disorders (FASD); however, no study has reported all three measures within the same cohort to assess the relative magnitude of deficits, and few studies have examined sex differences. Participants with FASD (n = 70; 30 females; 5-32 years) and healthy controls (n = 74; 35 females; 5-32 years) underwent cognitive testing and MRI to assess cortical thickness, regional brain volumes and fractional anisotropy (FA)/mean diffusivity (MD) of white matter tracts...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560152/improved-cerebral-microbleeds-detection-using-their-magnetic-signature-on-t2-phase-contrast-a-comparison-study-in-a-clinical-setting
#19
Takoua Kaaouana, Anne Bertrand, Fatma Ouamer, Bruno Law-Ye, Nadya Pyatigorskaya, Ali Bouyahia, Nathalie Thiery, Carole Dufouil, Christine Delmaire, Didier Dormont, Ludovic de Rochefort, Marie Chupin
INTRODUCTION/PURPOSE: In vivo detection of cerebral microbleeds (CMBs) from T2* gradient recalled echo (GRE) magnitude image suffers from low specificity, modest inter-rater reproducibility and is biased by its sensitivity to acquisition parameters. New methods were proposed for improving this identification, but they mostly rely on 3D acquisitions, not always feasible in clinical practice. A fast 2D phase processing technique for computing internal field maps (IFM) has been shown to make it possible to characterize CMBs through their magnetic signature in routine clinical setting, based on 2D multi-slice acquisitions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28560151/auditory-prediction-errors-as-individual-biomarkers-of-schizophrenia
#20
J A Taylor, N Matthews, P T Michie, M J Rosa, M I Garrido
Schizophrenia is a complex psychiatric disorder, typically diagnosed through symptomatic evidence collected through patient interview. We aim to develop an objective biologically-based computational tool which aids diagnosis and relies on accessible imaging technologies such as electroencephalography (EEG). To achieve this, we used machine learning techniques and a combination of paradigms designed to elicit prediction errors or Mismatch Negativity (MMN) responses. MMN, an EEG component elicited by unpredictable changes in sequences of auditory stimuli, has previously been shown to be reduced in people with schizophrenia and this is arguably one of the most reproducible neurophysiological markers of schizophrenia...
2017: NeuroImage: Clinical
journal
journal
47559
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"