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NeuroImage: Clinical

Marita Partanen, Eric Bouffet, Suzanne Laughlin, Douglas Strother, Juliette Hukin, Jovanka Skocic, Kamila Szulc-Lerch, Donald J Mabbott
PURPOSE: Prospective and longitudinal neuroimaging studies of posterior fossa tumors are scarce. Here we evaluate the early changes in white matter and intellectual outcome up to 3 years after diagnosis. PATIENTS AND METHODS: Twenty-two children with posterior fossa tumors and 24 similarly-aged healthy children participated. Patients included: (a) 12 individuals who received surgery, cranial-spinal radiation (CSR), and focal radiation to the tumor bed (CSR group) and (b) 10 individuals who received local therapy, either surgery only or surgery and focal radiation to the tumor bed (Local group)...
September 6, 2018: NeuroImage: Clinical
Sana Hannan, Mayo Faulkner, Kirill Aristovich, James Avery, Matthew Walker, David Holder
Electrical Impedance Tomography (EIT) is an emerging medical imaging technique which can produce tomographic images of internal impedance changes within an object using non-penetrating surface electrodes. It has previously been used to image impedance changes due to neuronal depolarisation during evoked potentials in the rat somatosensory cortex with a resolution of 2 ms and <200 μm, using an epicortical electrode array. The purpose of this work was to use this technique to elucidate the intracortical spatiotemporal trajectory of ictal spike-and-wave discharges (SWDs), induced by electrical stimulation in an acute rat model of epilepsy, throughout the cerebral cortex...
September 5, 2018: NeuroImage: Clinical
André M Paschoal, Renata F Leoni, Antonio C Dos Santos, Fernando F Paiva
Intravoxel Incoherent Motion (IVIM) is a recently rediscovered noninvasive magnetic resonance imaging (MRI) method based on diffusion-weighted imaging. It enables the separation of the intravoxel signal into diffusion due to Brownian motion and perfusion-related contributions and provides important information on microperfusion in the tissue and therefore it is a promising tool for applications in neurological and neurovascular diseases. This review focuses on the basic principles and outputs of IVIM and details it major applications in the brain, such as stroke, tumor, and cerebral small vessel disease...
August 31, 2018: NeuroImage: Clinical
Jillian McCarthy, D Louis Collins, Simon Ducharme
Frontotemporal dementia (FTD) is difficult to diagnose, due to its heterogeneous nature and overlap in symptoms with primary psychiatric disorders. Brain MRI for atrophy is a key biomarker but lacks sensitivity in the early stage. Morphometric MRI-based measures and machine learning techniques are a promising tool to improve diagnostic accuracy. Our aim was to review the current state of the literature using morphometric MRI to classify FTD and assess its applicability for clinical practice. A search was completed using Pubmed and PsychInfo of studies which conducted a classification of subjects with FTD from non-FTD (controls or another disorder) using morphometric MRI metrics on an individual level, using single or combined approaches...
August 31, 2018: NeuroImage: Clinical
Stelios Angeli, Kyrre E Emblem, Paulina Due-Tonnessen, Triantafyllos Stylianopoulos
Previous studies to simulate brain tumor progression, often investigate either temporal changes in cancer cell density or the overall tissue-level growth of the tumor mass. Here, we developed a computational model to bridge these two approaches. The model incorporates the tumor biomechanical response at the tissue level and accounts for cellular events by modeling cancer cell proliferation, infiltration to surrounding tissues, and invasion to distant locations. Moreover, acquisition of high resolution human data from anatomical magnetic resonance imaging, diffusion tensor imaging and perfusion imaging was employed within the simulations towards a realistic and patient specific model...
2018: NeuroImage: Clinical
Carrie W Hoppes, Patrick J Sparto, Susan L Whitney, Joseph M Furman, Theodore J Huppert
Background and purpose: Individuals with visual vertigo (VV) describe symptoms of dizziness, disorientation, and/or impaired balance in environments with conflicting visual and vestibular information or complex visual stimuli. Physical therapists often prescribe habituation exercises using optic flow to treat these symptoms, but it is not known how individuals with VV process the visual stimuli. The primary purpose of this study was to use functional near-infrared spectroscopy (fNIRS) to determine if individuals with VV have different cerebral activation during optic flow compared with control subjects...
2018: NeuroImage: Clinical
Lisa A van der Kleij, Esben T Petersen, Hartwig R Siebner, Jeroen Hendrikse, Kristian S Frederiksen, Nanna A Sobol, Steen G Hasselbalch, Ellen Garde
In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow...
2018: NeuroImage: Clinical
Benedikt Hofmeier, Stephan Wolpert, Ebrahim Saad Aldamer, Moritz Walter, John Thiericke, Christoph Braun, Dennis Zelle, Lukas Rüttiger, Uwe Klose, Marlies Knipper
The exact neurophysiological basis of chronic tinnitus, which affects 10-15% of the population, remains unknown and is controversial at many levels. It is an open question whether phantom sound perception results from increased central neural gain or not, a crucial question for any future therapeutic intervention strategies for tinnitus. We performed a comprehensive study of mild hearing-impaired participants with and without tinnitus, excluding participants with co-occurrences of hyperacusis. A right-hemisphere correlation between tinnitus loudness and auditory perceptual difficulty was observed in the tinnitus group, independent of differences in hearing thresholds...
2018: NeuroImage: Clinical
Giulia M Giordano, Thomas Koenig, Armida Mucci, Annarita Vignapiano, Antonella Amodio, Giorgio Di Lorenzo, Alberto Siracusano, Antonello Bellomo, Mario Altamura, Palmiero Monteleone, Maurizio Pompili, Silvana Galderisi, Mario Maj
Background: The "Avolition-apathy" domain of the negative symptoms was found to include different symptoms by factor analytic studies on ratings derived by different scales. In particular, the relationship of anhedonia with this domain is controversial. Recently introduced negative symptom rating scales provide a better assessment of anhedonia, allowing the distinction of anticipatory and consummatory aspects, which might be related to different psychopathological dimensions...
2018: NeuroImage: Clinical
Victoria N Poole, Thomas Wooten, Ikechukwu Iloputaife, William Milberg, Michael Esterman, Lewis A Lipsitz
Our previous work demonstrates that reduced activation of the executive network is associated with slow walking speed in a cohort of older adults from the MOBILIZE Boston Study. However, the influence of underlying white matter integrity on the activation of this network and walking speed is unknown. Thus, we used diffusion-weighted imaging and fMRI during an n-back task to assess associations between executive network structure, function, and walking speed. Whole-brain tract-based spatial statistics (TBSS) were used to identify regions of white matter microstructural integrity that were associated with walking speed...
2018: NeuroImage: Clinical
Ying Zhao, Matthew A Lambon Ralph, Ajay D Halai
Linking both structural lesions and the functional integrity of remaining brain tissue to patients' behavioural profile may be critical in discovering the limits of behavioural recovery post stroke. In the present study, we explored the relationship between temporal hemodynamic changes and language performance in chronic post-stroke aphasia. We collected detailed language and neuropsychological data for 66 patients with chronic (>1 year) post-stroke aphasia. We used principal component analysis to extract their core language-neuropsychological features...
2018: NeuroImage: Clinical
Francisco Oliveira, Antoine Leuzy, João Castelhano, Konstantinos Chiotis, Steen Gregers Hasselbalch, Juha Rinne, Alexandre Mendonça, Markus Otto, Alberto Lleó, Isabel Santana, Jarkko Johansson, Sarah Anderl-Straub, Christine Arnim, Ambros Beer, Rafael Blesa, Juan Fortea, Herukka Sanna-Kaisa, Erik Portelius, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Ana P Moreira, Antero Abrunhosa, Agneta Nordberg, Miguel Castelo-Branco
Positron emission tomography (PET) neuroimaging with the Pittsburgh Compound_B (PiB) is widely used to assess amyloid plaque burden. Standard quantification approaches normalize PiB-PET by mean cerebellar gray matter uptake. Previous studies suggested similar pons and white-matter uptake in Alzheimer's disease (AD) and healthy controls (HC), but lack exhaustive comparison of normalization across the three regions, with data-driven diagnostic classification. We aimed to compare the impact of distinct reference regions in normalization, measured by data-driven statistical analysis, and correlation with cerebrospinal fluid (CSF) amyloid β (Aβ) species concentrations...
2018: NeuroImage: Clinical
Wei Zhao, Shuixia Guo, Ningning He, Albert C Yang, Ching-Po Lin, Shih-Jen Tsai
Diffusion tensor imaging and its distinct capability to detect micro-structural changes in vivo allows the exploration of white matter (WM) abnormalities in patients who have been diagnosed with schizophrenia; however, the results regarding the anatomical positions and degree of abnormalities are inconsistent. In order to obtain more robust and stable findings, we conducted a multi-level analysis to investigate WM disruption in a relatively large sample size (142 schizophrenia patients and 163 healthy subjects)...
2018: NeuroImage: Clinical
Volker A Coenen, Bastian Sajonz, Marco Reisert, Jan Bostroem, Bettina Bewernick, Horst Urbach, Carolin Jenkner, Peter C Reinacher, Thomas E Schlaepfer, Burkhard Mädler
Background: Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (slMFB) emerges as a - yet experimental - treatment for major depressive disorder (MDD) and other treatment refractory psychiatric diseases. First experiences have been reported from two open label pilot trials in major depression (MDD) and long-term effectiveness for MDD (50 months) has been reported. Objective: To give a detailed description of the surgical technique for DBS of the superolateral branch of the medial forebrain bundle (slMFB) in MDD...
2018: NeuroImage: Clinical
Dawn C Matthews, Hedva Lerman, Ana Lukic, Randolph D Andrews, Anat Mirelman, Miles N Wernick, Nir Giladi, Stephen C Strother, Karleyton C Evans, Jesse M Cedarbaum, Einat Even-Sapir
Background: The development of therapeutic interventions for Parkinson disease (PD) is challenged by disease complexity and subjectivity of symptom evaluation. A Parkinson's Disease Related Pattern (PDRP) of glucose metabolism via fluorodeoxyglucose positron emission tomography (FDG-PET) has been reported to correlate with motor symptom scores and may aid the detection of disease-modifying therapeutic effects. Objectives: We sought to independently evaluate the potential utility of the PDRP as a biomarker for clinical trials of early-stage PD...
2018: NeuroImage: Clinical
Sorrentino Pierpaolo, Rucco Rosaria, Jacini Francesca, Trojsi Francesca, Lardone Anna, Baselice Fabio, Femiano Cinzia, Santangelo Gabriella, Granata Carmine, Vettoliere Antonio, Monsurrò Maria Rosaria, Tedeschi Gioacchino, Sorrentino Giuseppe
This study hypothesizes that the brain shows hyper connectedness as amyotrophic lateral sclerosis (ALS) progresses. 54 patients (classified as "early stage" or "advanced stage") and 25 controls underwent magnetoencephalography and MRI recordings. The activity of the brain areas was reconstructed, and the synchronization between them was estimated in the classical frequency bands using the phase lag index. Brain topological metrics such as the leaf fraction (number of nodes with degree of 1), the degree divergence (a measure of the scale-freeness) and the degree correlation (a measure of disassortativity) were estimated...
2018: NeuroImage: Clinical
Maryam Seif, Armin Curt, Alan J Thompson, Patrick Grabher, Nikolaus Weiskopf, Patrick Freund
Objective: To reveal the immediate extent of trauma-induced neurodegenerative changes rostral to the level of lesion and determine the predictive clinical value of quantitative MRI (qMRI) following acute spinal cord injury (SCI). Methods: Twenty-four acute SCI patients and 23 healthy controls underwent a high-resolution T1-weighted protocol. Eighteen of those patients and 20 of controls additionally underwent a multi-parameter mapping (MPM) MRI protocol sensitive to the content of tissue structure, including myelin and iron...
2018: NeuroImage: Clinical
Masaya Misaki, Raquel Phillips, Vadim Zotev, Chung-Ki Wong, Brent E Wurfel, Frank Krueger, Matthew Feldner, Jerzy Bodurka
Self-regulation of brain activation using real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) is an emerging approach for treating mood and anxiety disorders. The effect of neurofeedback training on resting-state functional connectivity warrants investigation as changes in spontaneous brain activation could reflect the association between sustained symptom relief and brain alteration. We investigated the effect of amygdala-focused rtfMRI-nf training on resting-state functional connectivity in combat veterans with and without posttraumatic stress disorder (PTSD) who were trained to increase a feedback signal reflecting left amygdala activity while recalling positive autobiographical memories (Zotev et al...
2018: NeuroImage: Clinical
Philipp Lohmann, Martin Kocher, Garry Ceccon, Elena K Bauer, Gabriele Stoffels, Shivakumar Viswanathan, Maximilian I Ruge, Bernd Neumaier, Nadim J Shah, Gereon R Fink, Karl-Josef Langen, Norbert Galldiks
Background: The aim of this study was to investigate the potential of combined textural feature analysis of contrast-enhanced MRI (CE-MRI) and static O-(2-[18 F]fluoroethyl)-L-tyrosine (FET) PET for the differentiation between local recurrent brain metastasis and radiation injury since CE-MRI often remains inconclusive. Methods: Fifty-two patients with new or progressive contrast-enhancing brain lesions on MRI after radiotherapy (predominantly stereotactic radiosurgery) of brain metastases were additionally investigated using FET PET...
2018: NeuroImage: Clinical
Catherine D Chong, Jonathan D Plasencia, David H Frakes, Todd J Schwedt
[This corrects the article DOI: 10.1016/j.nicl.2016.10.023.].
2018: NeuroImage: Clinical
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