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NeuroImage: Clinical

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https://www.readbyqxmd.com/read/28210542/dynamic-association-between-perfusion-and-white-matter-integrity-across-time-since-injury-in-veterans-with-history-of-tbi
#1
Alexandra L Clark, Katherine J Bangen, Scott F Sorg, Dawn M Schiehser, Nicole D Evangelista, Benjamin McKenna, Thomas T Liu, Lisa Delano-Wood
OBJECTIVE: Cerebral blood flow (CBF) plays a critical role in the maintenance of neuronal integrity, and CBF alterations have been linked to deleterious white matter changes. Although both CBF and white matter microstructural alterations have been observed within the context of traumatic brain injury (TBI), the degree to which these pathological changes relate to one another and whether this association is altered by time since injury have not been examined. The current study therefore sought to clarify associations between resting CBF and white matter microstructure post-TBI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28210541/a-t1-and-dti-fused-3d-corpus-callosum-analysis-in-mci-subjects-with-high-and-low-cardiovascular-risk-profile
#2
Yi Lao, Binh Nguyen, Sinchai Tsao, Niharika Gajawelli, Meng Law, Helena Chui, Michael Weiner, Yalin Wang, Natasha Leporé
Understanding the extent to which vascular disease and its risk factors are associated with prodromal dementia, notably Alzheimer's disease (AD), may enhance predictive accuracy as well as guide early interventions. One promising avenue to determine this relationship consists of looking for reliable and sensitive in-vivo imaging methods capable of characterizing the subtle brain alterations before the clinical manifestations. However, little is known from the imaging perspective about how risk factors such as vascular disease influence AD progression...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28203531/an-fmri-study-of-implicit-language-learning-in-developmental-language-impairment
#3
Elena Plante, Dianne Patterson, Michelle Sandoval, Christopher J Vance, Arve E Asbjørnsen
Individuals with developmental language impairment can show deficits into adulthood. This suggests that neural networks related to their language do not normalize with time. We examined the ability of 16 adults with and without impaired language to learn individual words in an unfamiliar language. Adults with impaired language were able to segment individual words from running speech, but needed more time to do so than their normal-language peers. ICA analysis of fMRI data indicated that adults with language impairment activate a neural network that is comparable to that of adults with normal language...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28203530/longitudinal-evaluation-of-cerebral-and-spinal-cord-damage-in-amyotrophic-lateral-sclerosis
#4
Milena de Albuquerque, Lucas Melo T Branco, Thiago Junqueira R Rezende, Helen Maia Tavares de Andrade, Anamarli Nucci, Marcondes Cavalcante França
OBJECTIVE: To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral Sclerosis (ALS) progression. METHODS: Twenty-seven patients and 27 controls performed two clinical and MRI acquisitions 8 months apart. ALSFRS-R scale was used to quantify disease severity at both time points. Multimodal analyses of MRI included cortical thickness measurements (FreeSurfer software), analysis of white matter integrity using diffusion-tensor imaging (tract-based spatial statistics-TBSS) and measurement of cervical spinal cord cross-sectional area (SpineSeg software)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28203529/reality-monitoring-impairment-in-schizophrenia-reflects-specific-prefrontal-cortex-dysfunction
#5
Jane R Garrison, Emilio Fernandez-Egea, Rashid Zaman, Mark Agius, Jon S Simons
Reality monitoring impairment is often reported in schizophrenia but the neural basis of this deficit is poorly understood. Difficulties with reality monitoring could be attributable to the same pattern of neural dysfunction as other cognitive deficits that characterize schizophrenia, or might instead represent a separable and dissociable impairment. This question was addressed through direct comparison of behavioral performance and neural activity associated with reality monitoring and working memory in patients with schizophrenia and matched healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28203528/persistent-amygdala-novelty-response-is-associated-with-less-anterior-cingulum-integrity-in-trauma-exposed-women
#6
Seungyeon A Yoon, Mariann R Weierich
OBJECTIVES: We investigated the potential role of cingulum and uncinate fasciculus integrity in trauma-related neural hypervigilance, indexed by less discrimination between amygdala activation to novel and familiar affective images. PARTICIPANTS: 22 women (mean age 21.7 ± 3.9 years) with a history of trauma, and 20 no-trauma controls (mean age 21.9 ± 4.8 years). MEASURES: Trauma exposure and trauma-related symptoms were assessed during structured clinical interview...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180083/lateralized-occipital-degeneration-in-posterior-cortical-atrophy-predicts-visual-field-deficits
#7
Rebecca S Millington, Merle James-Galton, Mari N Maia Da Silva, Gordon T Plant, Holly Bridge
BACKGROUND: Posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, leads to high-level visual deficits such as alexia or agnosia. Visual field deficits have also been identified, but often inconsistently reported. Little is known about the pattern of visual field deficits or the underlying cortical changes leading to this visual loss. METHODS: Multi-modal magnetic resonance imaging was used to investigate differences in gray matter volume, cortical thickness, white matter microstructure and functional activity in patients with PCA compared to age-matched controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180082/executive-attention-deficits-after-traumatic-brain-injury-reflect-impaired-recruitment-of-resources
#8
Sudhin A Shah, Yelena Goldin, Mary M Conte, Andrew M Goldfine, Maliheh Mohamadpour, Brian C Fidali, Keith Cicerone, Nicholas D Schiff
Deficits in attention are a common and devastating consequence of traumatic brain injury (TBI), leading to functional impairments, rehabilitation barriers, and long-term disability. While such deficits are well documented, little is known about their underlying pathophysiology hindering development of effective and targeted interventions. Here we evaluate the integrity of brain systems specific to attentional functions using quantitative assessments of electroencephalography recorded during performance of the Attention Network Test (ANT), a behavioral paradigm that separates alerting, orienting, and executive components of attention...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180081/automatic-quantification-of-ischemic-injury-on-diffusion-weighted-mri-of-neonatal-hypoxic-ischemic-encephalopathy
#9
Keelin Murphy, Niek E van der Aa, Simona Negro, Floris Groenendaal, Linda S de Vries, Max A Viergever, Geraldine B Boylan, Manon J N L Benders, Ivana Išgum
A fully automatic method for detection and quantification of ischemic lesions in diffusion-weighted MR images of neonatal hypoxic ischemic encephalopathy (HIE) is presented. Ischemic lesions are manually segmented by two independent observers in 1.5 T data from 20 subjects and an automatic algorithm using a random forest classifier is developed and trained on the annotations of observer 1. The algorithm obtains a median sensitivity and specificity of 0.72 and 0.99 respectively. F1-scores are calculated per subject for algorithm performance (median = 0...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180080/simultaneous-investigation-of-microvasculature-and-parenchyma-in-cerebral-small-vessel-disease-using-intravoxel-incoherent-motion-imaging
#10
Sau May Wong, C Eleana Zhang, Frank C G van Bussel, Julie Staals, Cécile R L P N Jeukens, Paul A M Hofman, Robert J van Oostenbrugge, Walter H Backes, Jacobus F A Jansen
INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 ± 11 y) and thirty-nine controls (age 69 ± 12 y) underwent IVIM imaging (3T)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180079/white-matter-tract-abnormalities-and-antisocial-behavior-a-systematic-review-of-diffusion-tensor-imaging-studies-across-development
#11
REVIEW
Rebecca Waller, Hailey L Dotterer, Laura Murray, Andrea M Maxwell, Luke W Hyde
Antisocial behavior (AB), including aggression, violence, and theft, is thought be underpinned by abnormal functioning in networks of the brain critical to emotion processing, behavioral control, and reward-related learning. To better understand the abnormal functioning of these networks, research has begun to investigate the structural connections between brain regions implicated in AB using diffusion tensor imaging (DTI), which assesses white-matter tract microstructure. This systematic review integrates findings from 22 studies that examined the relationship between white-matter microstructure and AB across development...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180078/acute-stress-effects-on-gaba-and-glutamate-levels-in-the-prefrontal-cortex-a-7t-1-h-magnetic-resonance-spectroscopy-study
#12
L C Houtepen, R R Schür, J P Wijnen, V O Boer, M P M Boks, R S Kahn, M Joëls, D W Klomp, C H Vinkers
There is ample evidence that the inhibitory GABA and the excitatory glutamate system are essential for an adequate response to stress. Both GABAergic and glutamatergic brain circuits modulate hypothalamus-pituitary-adrenal (HPA)-axis activity, and stress in turn affects glutamate and GABA levels in the rodent brain. However, studies examining stress-induced GABA and glutamate levels in the human brain are scarce. Therefore, we investigated the influence of acute psychosocial stress (using the Trier Social Stress Test) on glutamate and GABA levels in the medial prefrontal cortex of 29 healthy male individuals using 7 Tesla proton magnetic resonance spectroscopy...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180077/multicenter-stability-of-resting-state-fmri-in-the-detection-of-alzheimer-s-disease-and-amnestic-mci
#13
Stefan J Teipel, Alexandra Wohlert, Coraline Metzger, Timo Grimmer, Christian Sorg, Michael Ewers, Eva Meisenzahl, Stefan Klöppel, Viola Borchardt, Michel J Grothe, Martin Walter, Martin Dyrba
BACKGROUND: In monocentric studies, patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia exhibited alterations of functional cortical connectivity in resting-state functional MRI (rs-fMRI) analyses. Multicenter studies provide access to large sample sizes, but rs-fMRI may be particularly sensitive to multiscanner effects. METHODS: We used data from five centers of the "German resting-state initiative for diagnostic biomarkers" (psymri...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180076/face-name-association-task-reveals-memory-networks-in-patients-with-left-and-right-hippocampal-sclerosis
#14
Silke Klamer, Monika Milian, Michael Erb, Sabine Rona, Holger Lerche, Thomas Ethofer
We aimed to identify reorganization processes of episodic memory networks in patients with left and right temporal lobe epilepsy (TLE) due to hippocampal sclerosis as well as their relations to neuropsychological memory performance. We investigated 28 healthy subjects, 12 patients with left TLE (LTLE) and 9 patients with right TLE (RTLE) with hippocampal sclerosis by means of functional magnetic resonance imaging (fMRI) using a face-name association task, which combines verbal and non-verbal memory functions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180075/independent-value-added-by-diffusion-mri-for-prediction-of-cognitive-function-in-older-adults
#15
Julia A Scott, Duygu Tosun, Meredith N Braskie, Pauline Maillard, Paul M Thompson, Michael Weiner, Charles DeCarli, Owen T Carmichael
The purpose of this study was to determine whether white matter microstructure measured by diffusion magnetic resonance imaging (dMRI) provides independent information about baseline level or change in executive function (EF) or memory (MEM) in older adults with and without cognitive impairment. Longitudinal data was acquired from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study from phases GO and 2 (2009-2015). ADNI participants included were diagnosed as cognitively normal (n = 46), early mild cognitive impairment (MCI) (n = 48), late MCI (n = 29), and dementia (n = 39) at baseline...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180074/regional-staging-of-white-matter-signal-abnormalities-in-aging-and-alzheimer-s-disease
#16
Emily R Lindemer, Douglas N Greve, Bruce R Fischl, Jean C Augustinack, David H Salat
White matter lesions, quantified as 'white matter signal abnormalities' (WMSA) on neuroimaging, are common incidental findings on brain images of older adults. This tissue damage is linked to cerebrovascular dysfunction and is associated with cognitive decline. The regional distribution of WMSA throughout the cerebral white matter has been described at a gross scale; however, to date no prior study has described regional patterns relative to cortical gyral landmarks which may be important for understanding functional impact...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180073/reduced-fractional-anisotropy-in-patients-with-major-depressive-disorder-and-associations-with-vascular-stiffness
#17
Marco Hermesdorf, Klaus Berger, András Szentkirályi, Wolfram Schwindt, Udo Dannlowski, Heike Wersching
Previous studies revealed several alterations of the cerebral white matter in patients with major depressive disorder. However, it is unknown if these alterations are associated with vascular changes in the brain and other body parts. We compared diffusion tensor imaging derived fractional anisotropy in a well characterized sample of middle-aged patients with major depressive disorder (n = 290) and never-depressed controls (n = 346) by the method of tract-based spatial statistics. Subsequently, the potential role of pulse wave velocity as a mediator of depression- and age-related changes in extracted estimates of fractional anisotropy were analyzed...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180072/the-diminishing-dominance-of-the-dominant-hemisphere-language-fmri-in-focal-epilepsy
#18
Chris Tailby, David F Abbott, Graeme D Jackson
"Which is the dominant hemisphere?" is a question that arises frequently in patients considered for neurosurgery. The concept of the dominant hemisphere implies uniformity of language lateralisation throughout the brain. It is increasingly recognised that this is not the case in the healthy control brain, and it is especially not so in neurological diseases such as epilepsy. In the present work we adapt our published objective lateralisation method (based on the construction of laterality curves) for use with sub-lobar cortical, subcortical and cerebellar regions of interest (ROIs)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180071/grey-matter-alterations-in-migraine-a-systematic-review-and-meta-analysis
#19
Zhihua Jia, Shengyuan Yu
OBJECTIVES: To summarize and meta-analyze studies on changes in grey matter (GM) in patients with migraine. We aimed to determine whether there are concordant structural changes in the foci, whether structural changes are concordant with functional changes, and provide further understanding of the anatomy and biology of migraine. METHODS: We searched PubMed and Embase for relevant articles published between January 1985 and November 2015, and examined the references within relevant primary articles...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180070/disrupted-functional-connectivity-of-striatal-sub-regions-in-bell-s-palsy-patients
#20
Wenwen Song, Zhijian Cao, Courtney Lang, Minhui Dai, Lihua Xuan, Kun Lv, Fangyuan Cui, Kristen Jorgenson, Maosheng Xu, Jian Kong
The striatum plays an important role in controlling motor function in humans, and its degeneration has the ability to cause severe motor disorders. More specifically, previous studies have demonstrated a disruption in the connectivity of the cortico-striatal loop in patients suffering from motor disorders caused by dopamine dysregulation, such as Parkinson's disease. However, little is known about striatal functional connectivity in patients with motor dysfunction not caused by dopamine dysregulation. In this study, we used early-state Bell's palsy (BP) patients (within 14 days of onset) to investigate how functional connectivity between the striatum and motor cortex is affected by peripheral nerve injury in which the dopamine system remains fully functional...
2017: NeuroImage: Clinical
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