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NeuroImage: Clinical

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https://www.readbyqxmd.com/read/29785360/identical-patterns-of-cortico-efferent-tract-involvement-in-primary-lateral-sclerosis-and-amyotrophic-lateral-sclerosis-a-tract-of-interest-based-mri-study
#1
Hans-Peter Müller, Martin Gorges, Rebecca Kassubek, Johannes Dorst, Albert C Ludolph, Jan Kassubek
Background: There is an ongoing debate whether primary lateral sclerosis (PLS) should be regarded as an independent disease entity separate from amyotrophic lateral sclerosis (ALS) or as a slowly progressive variant of ALS. Objective: The study was designed to investigate specific white matter alterations in diffusion tensor imaging (DTI) data from PLS patients by a hypothesis-guided tract-of-interest-based approach compared with 'classical' ALS patients and healthy controls, in order to identify microstructural changes according to the neuropathologically defined ALS affectation pattern in vivo...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29785359/white-matter-microstructure-white-matter-lesions-and-hypertension-an-examination-of-early-surrogate-markers-of-vascular-related-brain-change-in-midlife
#2
Thaddeus Haight, R Nick Bryan, Guray Erus, Meng-Kang Hsieh, Christos Davatzikos, Ilya Nasrallah, Mark D'Esposito, David R Jacobs, Cora Lewis, Pamela Schreiner, Stephen Sidney, Osorio Meirelles, Lenore J Launer
Objective: We examined imaging surrogates of white matter microstructural abnormalities which may precede white matter lesions (WML) and represent a relevant marker of cerebrovascular injury in adults in midlife. Methods: In 698 community-dwelling adults (mean age 50 years ±3.5 SD) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study, WML were identified on structural MR and fractional anisotropy (FA), representing WM microstructural integrity, was derived using Diffusion Tensor Imaging...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29619318/the-behavioural-patterns-and-neural-correlates-of-concrete-and-abstract-verb-processing-in-aphasia-a-novel-verb-semantic-battery
#3
Reem S W Alyahya, Ajay D Halai, Paul Conroy, Matthew A Lambon Ralph
Typically, processing is more accurate and efficient for concrete than abstract concepts in both healthy adults and individuals with aphasia. While, concreteness effects have been thoroughly documented with respect to noun processing, other words classes have received little attention despite tending to be less concrete than nouns. The aim of the current study was to explore concrete-abstract differences in verbs and identify their neural correlates in post-stroke aphasia. Given the dearth of comprehension tests for verbs, a battery of neuropsychological tests was developed in this study to assess the comprehension of concrete and abstract verbs...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29619317/influence-of-inter-stimulus-interval-of-spinal-cord-stimulation-in-patients-with-disorders-of-consciousness-a-preliminary-functional-near-infrared-spectroscopy-study
#4
Yujin Zhang, Yi Yang, Juanning Si, Xiaoyu Xia, Jianghong He, Tianzi Jiang
Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29564209/food-product-health-warnings-promote-dietary-self-control-through-reductions-in-neural-signals-indexing-food-cue-reactivity
#5
Daniel H Rosenblatt, Patrick Summerell, Alyssa Ng, Helen Dixon, Carsten Murawski, Melanie Wakefield, Stefan Bode
Modern societies are replete with palatable food cues. A growing body of evidence suggests that food cue exposure activates conditioned appetitive physiological and psychological responses that may override current metabolic needs and existing eating goals, such as the desire to maintain a healthy diet. This conditioned response results in unhealthy dietary choices and is a contributing factor in the current obesity epidemic. Prime based obesity prevention measures such as health warnings at point-of-sale or on product packaging may have the potential to counteract the influence of the obesogenic environment at the crucial moment when people make food purchasing or consumption decisions...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29560312/relationship-between-muscarinic-m-1-receptor-binding-and-cognition-in-medication-free-subjects-with-psychosis
#6
Geor Bakker, Claudia Vingerhoets, Daphne Boucherie, Matthan Caan, Oswald Bloemen, Jos Eersels, Jan Booij, Thérèse van Amelsvoort
Background: It is still unclear which underlying mechanisms are involved in cognitive deficits of psychotic disorders. Pro-cognitive effects of muscarinic M1 receptor agonists suggest alterations in M1 receptor functioning may modulate these symptoms. Post mortem studies in patients with schizophrenia have shown significantly reduced M1 receptor expression rates in the dorsolateral prefrontal cortex (DLPFC) compared to controls. To date no in-vivo examinations of M1 receptor binding in relation to cognitive impairments have been done...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29560311/altered-network-hub-connectivity-after-acute-lsd-administration
#7
Felix Müller, Patrick C Dolder, André Schmidt, Matthias E Liechti, Stefan Borgwardt
LSD is an ambiguous substance, said to mimic psychosis and to improve mental health in people suffering from anxiety and depression. Little is known about the neuronal correlates of altered states of consciousness induced by this substance. Limited previous studies indicated profound changes in functional connectivity of resting state networks after the administration of LSD. The current investigation attempts to replicate and extend those findings in an independent sample. In a double-blind, randomized, cross-over study, 100 μg LSD and placebo were orally administered to 20 healthy participants...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29560310/neural-mechanisms-underlying-successful-and-deficient-multi-component-behavior-in-early-adolescent-adhd
#8
Annet Bluschke, Krutika Gohil, Maxi Petzold, Veit Roessner, Christian Beste
Attention Deficit Hyperactivity Disorder (ADHD) is a disorder affecting cognitive control. These functions are important to achieve goals when different actions need to be executed in close succession. This type of multi-component behavior, which often further requires the processing of information from different modalities, is important for everyday activities. Yet, possible changes in neurophysiological mechanisms have not been investigated in adolescent ADHD. We examined N = 31 adolescent ADHD patients and N = 35 healthy controls (HC) in two Stop-Change experiments using either uni-modal or bi-modal stimuli to trigger stop and change processes...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29560309/enhanced-temporal-variability-of-amygdala-frontal-functional-connectivity-in-patients-with-schizophrenia
#9
Jing-Li Yue, Peng Li, Le Shi, Xiao Lin, Hong-Qiang Sun, Lin Lu
Background: The "dysconnectivity hypothesis" was proposed 20 years ago. It characterized schizophrenia as a disorder with dysfunctional connectivity across a large range of distributed brain areas. Resting-state functional magnetic resonance imaging (rsfMRI) data have supported this theory. Previous studies revealed that the amygdala might be responsible for the emotion regulation-related symptoms of schizophrenia. However, conventional methods oversimplified brain activities by assuming that it remained static throughout the entire scan duration, which may explain why inconsistent results have been reported for the same brain region...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29560308/connectomic-markers-of-symptom-severity-in-sport-related-concussion-whole-brain-analysis-of-resting-state-fmri
#10
Nathan W Churchill, Michael G Hutchison, Simon J Graham, Tom A Schweizer
Concussion is associated with significant adverse effects within the first week post-injury, including physical complaints and altered cognition, sleep and mood. It is currently unknown whether these subjective disturbances have reliable functional brain correlates. Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to measure functional connectivity of individuals after traumatic brain injury, but less is known about the relationship between functional connectivity and symptom assessments after a sport concussion...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29560307/stress-related-dysfunction-of-the-right-inferior-frontal-cortex-in-high-ruminators-an-fnirs-study
#11
David Rosenbaum, Mara Thomas, Paula Hilsendegen, Florian G Metzger, Florian B Haeussinger, Hans-Christoph Nuerk, Andreas J Fallgatter, Vanessa Nieratschker, Ann-Christine Ehlis
Repetitive thinking styles such as rumination are considered to be a key factor in the development and maintenance of mental disorders. Different situational triggers (e.g., social stressors) have been shown to elicit rumination in subjects exhibiting such habitual thinking styles. At the same time, the process of rumination influences the adaption to stressful situations. The study at hand aims to investigate the effect of trait rumination on neuronal activation patterns during the Trier Social Stress Test (TSST) as well as the physiological and affective adaptation to this high-stress situation...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29560306/global-network-modulation-during-thalamic-stimulation-for-tourette-syndrome
#12
Hang Joon Jo, Kevin W McCairn, William S Gibson, Paola Testini, Cong Zhi Zhao, Krzysztof R Gorny, Joel P Felmlee, Kirk M Welker, Charles D Blaha, Bryan T Klassen, Hoon-Ki Min, Kendall H Lee
Background and objectives: Deep brain stimulation (DBS) of the thalamus is a promising therapeutic alternative for treating medically refractory Tourette syndrome (TS). However, few human studies have examined its mechanism of action. Therefore, the networks that mediate the therapeutic effects of thalamic DBS remain poorly understood. Methods: Five participants diagnosed with severe medically refractory TS underwent bilateral thalamic DBS stereotactic surgery. Intraoperative fMRI characterized the blood oxygen level-dependent (BOLD) response evoked by thalamic DBS and determined whether the therapeutic effectiveness of thalamic DBS, as assessed using the Modified Rush Video Rating Scale test, would correlate with evoked BOLD responses in motor and limbic cortical and subcortical regions...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29552486/network-connectivity-of-motor-control-in-the-ageing-brain
#13
J Michely, L J Volz, F Hoffstaedter, M Tittgemeyer, S B Eickhoff, G R Fink, C Grefkes
Older individuals typically display stronger regional brain activity than younger subjects during motor performance. However, knowledge regarding age-related changes of motor network interactions between brain regions remains scarce. We here investigated the impact of ageing on the interaction of cortical areas during movement selection and initiation using dynamic causal modelling (DCM). We found that age-related psychomotor slowing was accompanied by increases in both regional activity and effective connectivity, especially for 'core' motor coupling targeting primary motor cortex (M1)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29541577/-18-f-fallypride-characterization-of-striatal-and-extrastriatal-d-2-3-receptors-in-parkinson-s-disease
#14
Adam J Stark, Christopher T Smith, Kalen J Petersen, Paula Trujillo, Nelleke C van Wouwe, Manus J Donahue, Robert M Kessler, Ariel Y Deutch, David H Zald, Daniel O Claassen
Parkinson's disease (PD) is characterized by widespread degeneration of monoaminergic (especially dopaminergic) networks, manifesting with a number of both motor and non-motor symptoms. Regional alterations to dopamine D2/3 receptors in PD patients are documented in striatal and some extrastriatal areas, and medications that target D2/3 receptors can improve motor and non-motor symptoms. However, data regarding the combined pattern of D2/3 receptor binding in both striatal and extrastriatal regions in PD are limited...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29541576/a-comparison-of-functional-and-tractography-based-networks-in-cerebral-small-vessel-disease
#15
Andrew J Lawrence, Daniel J Tozer, Emmanuel A Stamatakis, Hugh S Markus
Objective: MRI measures of network integrity may be useful disease markers in cerebral small vessel disease (SVD). We compared the sensitivity and reproducibility of MRI derived structural and functional network measures in healthy controls and SVD subjects. Methods: Diffusion tractography and resting state fMRI were used to create connectivity matrices from 26 subjects with symptomatic MRI confirmed lacunar stroke and 19 controls. Matrices were constructed at multiple scales based on a multi-resolution cortical atlas and at multiple thresholds for the matrix density...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29541575/comparing-fmri-activation-during-smooth-pursuit-eye-movements-among-contact-sport-athletes-non-contact-sport-athletes-and-non-athletes
#16
Derek Kellar, Sharlene Newman, Franco Pestilli, Hu Cheng, Nicholas L Port
Objectives: Though sub-concussive impacts are common during contact sports, there is little consensus whether repeat blows affect brain function. Using a "lifetime exposure" rather than acute exposure approach, we examined oculomotor performance and brain activation among collegiate football players and two control groups. Our analysis examined whether there are group differences in eye movement behavioral performance and in brain activation during smooth pursuit. Methods: Data from 21 off-season Division I football "starters" were compared with a) 19 collegiate cross-country runners, and b) 11 non-athlete college students who were SES matched to the football player group (total N  = 51)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29527505/establishing-pathological-cut-offs-for-lateral-ventricular-volume-expansion-rates
#17
Michael G Dwyer, Jesper Hagemeier, Niels Bergsland, Dana Horakova, Jonathan R Korn, Nasreen Khan, Tomas Uher, Jennie Medin, Diego Silva, Manuela Vaneckova, Eva Kubala Havrdova, Robert Zivadinov
Background: A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish between pathological and physiological changes in multiple sclerosis (MS). Unfortunately, standardized PBVC measurement is not always feasible on scans acquired outside research studies or academic centers. Percent lateral ventricular volume change (PLVVC) is a strong surrogate measure of PBVC, and may be more feasible for atrophy assessment on real-world scans. However, the PLVVC rate corresponding to the established PBVC cut-off of -0...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29527504/combining-viscoelasticity-diffusivity-and-volume-of-the-hippocampus-for-the-diagnosis-of-alzheimer-s-disease-based-on-magnetic-resonance-imaging
#18
Lea M Gerischer, Andreas Fehlner, Theresa Köbe, Kristin Prehn, Daria Antonenko, Ulrike Grittner, Jürgen Braun, Ingolf Sack, Agnes Flöel
Dementia due to Alzheimer's Disease (AD) is a neurodegenerative disease for which treatment strategies at an early stage are of great clinical importance. So far, there is still a lack of non-invasive diagnostic tools to sensitively detect AD in early stages and to predict individual disease progression. Magnetic resonance elastography (MRE) of the brain may be a promising novel tool. In this proof-of-concept study, we investigated whether multifrequency-MRE (MMRE) can detect differences in hippocampal stiffness between patients with clinical diagnosis of dementia due to AD and healthy controls (HC)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29527503/the-potential-value-of-probabilistic-tractography-based-for-mr-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#19
Evangelia Tsolaki, Angela Downes, William Speier, W Jeff Elias, Nader Pouratian
Magnetic Resonance-guided Focused UltraSound (MRgFUS) offers an incisionless approach to treat essential tremor (ET). Due to lack of evident internal anatomy on traditional structural imaging, indirect targeting must still be used to localize the lesion. Here, we investigate the potential predictive value of probabilistic tractography guided thalamic targeting by defining how tractography-defined targets, lesion size and location, and clinical outcomes interrelate. MR imaging and clinical outcomes from 12 ET patients that underwent MRgFUS thalamotomy in a pilot study at the University of Virginia were evaluated in this analysis...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29527502/systematic-comparison-of-different-techniques-to-measure-hippocampal-subfield-volumes-in-adni2
#20
Susanne G Mueller, Paul A Yushkevich, Sandhitsu Das, Lei Wang, Koen Van Leemput, Juan Eugenio Iglesias, Kate Alpert, Adam Mezher, Peter Ng, Katrina Paz, Michael W Weiner
Objective: Subfield-specific measurements provide superior information in the early stages of neurodegenerative diseases compared to global hippocampal measurements. The overall goal was to systematically compare the performance of five representative manual and automated T1 and T2 based subfield labeling techniques in a sub-set of the ADNI2 population. Methods: The high resolution T2 weighted hippocampal images (T2-HighRes) and the corresponding T1 images from 106 ADNI2 subjects (41 controls, 57 MCI, 8 AD) were processed as follows...
2018: NeuroImage: Clinical
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