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Journals Translational Vision Science &...

Translational Vision Science & Technology

https://read.qxmd.com/read/38436966/erratum-in-perceptual-learning-based-on-the-lateral-masking-paradigm-in-anisometropic-amblyopia-with-or-without-a-patching-history
#21
JOURNAL ARTICLE
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No abstract text is available yet for this article.
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38427349/peripapillary-atrophy-area-as-an-indicator-of-glaucomatous-structural-and-functional-progression
#22
JOURNAL ARTICLE
Maroun Khreish, Joel S Schuman, TingFang Lee, Zeinab Ghassabi, Ronald Zambrano, Jiyuan Hu, Hiroshi Ishikawa, Gadi Wollstein, Fabio Lavinsky
PURPOSE: To determine whether peripapillary atrophy (PPA) area is an indicator of glaucomatous structural and functional damage and progression. METHODS: In this retrospective longitudinal analysis from ongoing prospective study we qualified 71 eyes (50 subjects) with glaucoma. All subjects had a comprehensive ophthalmic examination, visual field (VF), and spectral-domain optical coherence tomography (OCT) testing in at least three visits. PPA was manually delineated on en face OCT optic nerve head scans, while observing the corresponding cross-sectional images, as the hyper-reflective area contiguous with the optic disc...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38427348/inequalities-in-uptake-and-use-of-digital-applications-for-home-monitoring-of-neovascular-age-related-macular-degeneration-in-an-elderly-visually-impaired-population-the-monarch-study
#23
JOURNAL ARTICLE
Ruth E Hogg, Robin Wickens, Sean O'Connor, Eleanor Gidman, Elizabeth Ward, Tunde Peto, Benjamen J L Burton, Paul Knox, Andrew J Lotery, Sobha Sivaprasad, Michael Donnelly, Chris A Rogers, Barnaby C Reeves
PURPOSE: To describe inequalities in the Monitoring for Neovascular Age-related Macular Degeneration Reactivation at Home (MONARCH) diagnostic test accuracy study for: recruitment; participants' ability to self-test; and adherence to testing using digital applications during follow-up. METHODS: Home-monitoring vision tests included two tests implemented as software applications (apps: MyVisionTrack and MultiBit) on an iPod Touch device. Patients were provided with all hardware required to participate (iPod and MIFI device) and trained to use the apps...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38411971/assessment-of-causality-between-diet-derived-antioxidants-and-primary-open-angle-glaucoma-a-mendelian-randomization-study
#24
JOURNAL ARTICLE
Kun Xiong, Qi'ao Zhang, Huiyan Mao, Nathan Congdon, Yuanbo Liang
PURPOSE: This study aimed to investigate the genetic causal relationships among diet-derived circulating antioxidants, primary open-angle glaucoma (POAG), and glaucoma-related traits using two-sample Mendelian randomization (MR). METHODS: Genetic variants associated with diet-derived circulating antioxidants (retinol, ascorbate, β-carotene, lycopene, α-tocopherol, and γ-tocopherol) were assessed as absolute and metabolic instrumental variables...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38411970/two-disparity-channels-in-human-visual-cortex-with-different-contrast-and-blur-sensitivity
#25
JOURNAL ARTICLE
Milena Kaestner, Yulan D Chen, Caroline Clement, Alex Hodges, Anthony M Norcia
PURPOSE: Our goal is to describe the contrast and blur sensitivity of multiple horizontal disparity subsystems and to relate them to the contrast and spatial sensitivities of their monocular inputs. METHODS: Steady-state visual evoked potential (SSVEP) amplitudes were recorded in response to dynamic random dot stereograms (DRDSs) alternating at 2 Hz between zero disparity and varying magnitudes of crossed disparity for disparity plane and disparity grating stimuli...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38407885/effect-of-decentration-rotation-and-tilt-on-objective-optical-quality-of-plate-haptic-toric-intraocular-lenses-in-the-early-postoperative-period
#26
JOURNAL ARTICLE
Yingying Hong, Yang Sun, Houyi Liu, Yinghong Ji
PURPOSE: This study aimed to determine the influence of decentration, rotation, and tilt on objective optical quality of plate haptic toric intraocular lenses (tIOLs). METHODS: The area ratio of modulation transfer function (MTF), strehl ratio of point spread function (PSF), and higher order aberrations (HOAs) for 3 mm and 5 mm pupil diameter (PD) were evaluated at postoperative 1 month. The retroillumination images pictured by OPD-scan III were used to quantify the degree of decentration and rotation, whereas the tIOL tilt was directly obtained by the tilt aberration...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38386347/development-of-a-machine-learning-based-tool-for-overnight-orthokeratology-lens-fitting
#27
JOURNAL ARTICLE
Seongbong Koo, Wook Kyum Kim, Yoo Kyung Park, Kiwon Jun, Dongyoung Kim, Ik Hee Ryu, Jin Kuk Kim, Tae Keun Yoo
PURPOSE: Orthokeratology (ortho-K) is widely used to control myopia. Overnight ortho-K lens fitting with the selection of appropriate parameters is an important technique for achieving successful reductions in myopic refractive error. In this study, we developed a machine-learning model that could select ortho-K lens parameters at an expert level. METHODS: Machine-learning models were established to predict the optimal ortho-K parameters, including toric lens option (toric or non-toric), overall diameter (OAD; 10...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38386346/simulating-the-effects-of-partial-neural-conduction-delays-in-the-visual-evoked-potential
#28
JOURNAL ARTICLE
Enyam K A Morny, Julia Haldina, Sven P Heinrich
PURPOSE: The purpose of this study was to understand the double peaks or broadening of P100 observed in some cases of optic neuritis by inducing conduction delays in healthy eyes through stimulus luminance manipulation in analogy to the perceptual Pulfrich effect. METHODS: Checkerboard pattern reversal visual evoked potentials (VEPs) with check sizes of 0.8 degrees, 0.4 degrees, and 0.2 degrees were recorded in healthy participants using two experiment variants...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38381447/deep-learning-and-machine-learning-algorithms-for-retinal-image-analysis-in-neurodegenerative-disease-systematic-review-of-datasets-and-models
#29
JOURNAL ARTICLE
Tyler Bahr, Truong A Vu, Jared J Tuttle, Raymond Iezzi
PURPOSE: Retinal images contain rich biomarker information for neurodegenerative disease. Recently, deep learning models have been used for automated neurodegenerative disease diagnosis and risk prediction using retinal images with good results. METHODS: In this review, we systematically report studies with datasets of retinal images from patients with neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, and others...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38376864/chorioretinal-atrophy-growth-after-voretigene-neparvovec-retinotopically-is-connected-to-retinal-functional-rescue
#30
JOURNAL ARTICLE
Krunoslav Stingl, Melanie Kempf, Ronja Jung, Katarina Stingl
PURPOSE: Chorioretinal atrophy growth after voretigene neparvovec has been reported recently with its positive correlation with successful treatment. This finding raised the question on long-term effects and the etiology of the chorioretinal atrophy. METHODS: Using local retinal functional diagnostics, we tested whether the atrophy growth is connected to the initial local functional improvement after the therapy. RESULTS: The results describe factors predicting the development of atrophy...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38376863/disparities-in-eye-care-utilization-among-refugee-and-migrant-populations
#31
JOURNAL ARTICLE
Ivan A Copado, Shahin Hallaj, Bharanidharan Radha Saseendrakumar, Sally L Baxter
PURPOSE: In this cross-sectional study, we examined refugee/migrant participants' health and eye care utilization compared to controls in San Diego County. METHODS: Data were collected from electronic health records (EHRs) at UCSD Health-affiliated medical centers. Through a manual review of EHRs, eligibility criteria to identify a cohort were developed. A total of 64 refugee/migrant participants and 95 control participants matched based on country of origin, age, and sex were included in the analysis...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38376862/in-vivo-evaluation-of-corneal-biomechanics-following-cross-linking-surgeries-using-optical-coherence-elastography-in-a-rabbit-model-of-keratoconus
#32
JOURNAL ARTICLE
Yanzhi Zhao, Yirui Zhu, Yange Yan, Hongwei Yang, Jingchao Liu, Yongan Lu, Yingjie Li, Guofu Huang
PURPOSE: Validation of the feasibility of novel acoustic radiation force optical coherence elastography (ARF-OCE) for the evaluation of biomechanical enhancement of the in vivo model of keratoconus by clinical cross-linking (CXL) surgery. METHODS: Twelve in vivo rabbit corneas were randomly divided into two groups. Both groups were treated with collagenase type II, and a keratoconus model was obtained. Then, the two groups were treated with CXL procedures with different irradiation energy of 15 J and 30 J (CXL-15 J and CXL-30 J, respectively)...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38359019/detection-of-ttr-amyloid-in-the-conjunctiva-using-a-novel-fluorescent-ocular-tracer
#33
JOURNAL ARTICLE
Julie Pilotte, Alex S Huang, Sami Khoury, Xiaowei Zhang, Ali Tafreshi, Peter Vanderklish, Stella T Sarraf, Jose S Pulido, Tatyana Milman
BACKGROUND: Transthyretin amyloidosis (ATTR) is a significant cause of cardiomyopathy and other morbidities in the elderly and Black Americans. ATTR can be treated with new disease-modifying therapies, but large shortfalls exist in its diagnosis. The objective of this study was to test whether TTR amyloid can be detected and imaged in the conjunctiva using a novel small-molecule fluorescent ocular tracer, with the implication that ATTR might be diagnosable by a simple eye examination...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38359018/healthcare-resource-utilization-and-costs-in-an-at-risk-population-with-diabetic-retinopathy
#34
JOURNAL ARTICLE
Vivian Rajeswaren, Vivian Lu, Hongan Chen, Jennifer L Patnaik, Niranjan Manoharan
PURPOSE: Several investigators have suggested the cost-effectiveness of earlier screening, management of risk factors, and early treatment for diabetic retinopathy (DR). We aimed to evaluate the extent of health care utilization and cost of delayed care by insurance type in a vulnerable patient population. METHODS: A retrospective analysis of patients with DR was conducted using electronic medical record (EMR) data from January 2014 to December 2020 at Denver Health Medical Center, a safety net institution...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38349778/histologic-and-immunohistochemical-characterization-of-ga-like-pathology-in-the-rat-subretinal-sodium-iodate-model
#35
JOURNAL ARTICLE
Poonam Naik, Rhonda Grebe, Imran A Bhutto, D Scott McLeod, Malia M Edwards
PURPOSE: Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration with multifactorial etiology and no well-established treatment. A model recapitulating the hallmarks would serve as a key to understanding the underlying pathologic mechanisms better. In this report, we further characterized our previously reported subretinal sodium iodate model of GA. METHODS: Retinal degeneration was induced in rats (6-8 weeks old) by subretinal injections of NaIO3 as described previously...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38345551/zeiss-plex-elite-9000-widefield-optical-coherence-tomography-angiography-as-screening-method-for-early-detection-of-retinal-hemangioblastomas-in-von-hippel-lindau-disease
#36
JOURNAL ARTICLE
Stefan J Lang, Michelle Dreesbach, Yannik Laich, Andreas Glatz, Daniel Boehringer, Viviane Grewing, Marianne Fritz, Felicitas Bucher, Wolf A Lagrèze, Peter M Maloca, Thomas Reinhard, Clemens Lange, Hansjuergen Agostini, Michael Reich
PURPOSE: To evaluate early detection of retinal hemangioblastomas (RHs) in von Hippel-Lindau disease (VHLD) with widefield optical coherence tomography angiography (wOCTA) compared to the standard of care in ophthalmologic VHLD screening in a routine clinical setting. METHODS: We conducted prospective comparisons of three screening methods: wOCTA, standard ophthalmoscopy, and fluorescein angiography (FA), which was performed only in uncertain cases. The numbers of detected RHs were compared among the three screening methods...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38345550/aprepitant-restores-corneal-sensitivity-and-reduces-pain-in%C3%A2-ded
#37
JOURNAL ARTICLE
Filippo Bonelli, Fabiola Campestre, Romina Mayra Lasagni Vitar, Ibrahim Halil Demirsoy, Philippe Fonteyne, Giulio Ferrari
PURPOSE: This study aims to assess the efficacy of two aprepitant formulations (X1 and X2), in a preclinical model of dry eye disease (DED) induced by benzalkonium chloride (BAK). METHODS: Two aprepitant formulations were tested on 7 to 8-week-old male mice for their efficacy. In vivo corneal fluorescein staining assessed epithelial damage as the primary end point on days 0, 3, 5, 7, 9, 12, and 14 using slit-lamp microscopy. The DED model was induced with 0.2% BAK twice daily for the first week and once daily for the next week...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38334704/characteristics-of-visual-function-in-children-with-cerebral-palsy-and-intellectual-disabilities-in-urban-beijing
#38
JOURNAL ARTICLE
Jun Tao, Rui Hao, Yatu Guo, Wei Zhang
OBJECTIVE: To investigate ocular development and the characteristics of visual function among children with cerebral palsy (CP) and intellectual disabilities in Beijing's Chaoyang District schools. METHODS: A total of 160 children (320 eyes) with CP and intellectual disabilities, including 86 males and 74 females aged between 6 and 18 years old (median, 13.5 years), were included in this study. A total of 214 healthy children aged 6 to 18 years (median, 10 years) were recruited as a control group for visual function, including 116 males and 98 females...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38329750/acanthamoeba-keratitis-in-china-genotypic-and-clinical-correlations
#39
JOURNAL ARTICLE
Jinding Pang, Zhenyu Wei, Leying Wang, Xiaoyan Guo, Qiankun Chen, Yuan Wei, Yan Peng, Zijun Zhang, Yuheng Zhang, Jiamin Liu, Zhen Cheng, Zhiqun Wang, Yang Zhang, Kexin Chen, Xizhan Xu, Xinxin Lu, Qingfeng Liang
PURPOSE: To investigate the relationship between Acanthamoeba genotypes, clinical manifestations, and outcomes in Acanthamoeba keratitis (AK) patients. METHODS: This retrospective study included 159 culture-confirmed AK patients. Patients' data were collected, including demographics, initial diagnosis, treatments, and clinical features. The genotype of Acanthamoeba was identified through sequencing the Diagnostic Fragment 3 (DF3) region in the small ribosomal subunit RNA genes...
February 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38329749/efficiency-precision-validity-and-reliability-of-glaucat-asian-computerized-adaptive-tests-in-measuring-glaucoma-related-quality-of-life
#40
JOURNAL ARTICLE
Eva K Fenwick, Ryan E K Man, Belicia Lim, Mani Baskaran, Monisha Nongpiur, Chelvin C A Sng, Jayant Venkatramani Iyer, Rahat Husain, Shamira Perera, Tina Wong, Jin Rong Low, Olivia Shimin Huang, Katherine Lun, Bao Sheng Loe, Tin Aung, Ecosse L Lamoureux
PURPOSE: To determine the efficiency, precision, and agreement of GlauCAT-Asian and its corresponding validity and reliability. METHODS: In this cross-sectional study, 219 participants (mean ± standard deviation age, 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects were recruited from glaucoma clinics in Singapore. Participants answered seven computerized adaptive testing (CAT) evaluations (Ocular Comfort, Activity Limitation, Lighting, Mobility, Concerns, Psychosocial, Glaucoma Management) and underwent eye examinations...
February 1, 2024: Translational Vision Science & Technology
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