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Translational Vision Science & Technology

Yuanjun Zhao, Sarah R Weber, Joshua Lease, Mariano Russo, Christopher A Siedlecki, Li-Chong Xu, Han Chen, Weiwei Wang, Michael Ford, Rafael Simó, Jeffrey M Sundstrom
Purpose: To investigate the molecular components of the vitreous in order to better understand retinal physiology and disease. Methods: Vitreous was acquired from patients undergoing vitrectomy for macular hole and/or epiretinal membrane, postmortem donors, and C57BL/6J mice. Unbiased proteomic analysis was performed via electrospray ionization tandem mass spectrometry (MS/MS). Gene ontology analysis was performed and results were confirmed with transmission electron microscopy, atomic force microscopy, and nanoparticle tracking analysis (NTA)...
May 2018: Translational Vision Science & Technology
Zhichao Wu, Denis S D Weng, Rashmi Rajshekhar, Abinaya Thenappan, Robert Ritch, Donald C Hood
Purpose: To determine the effectiveness of detecting glaucomatous progression by a qualitative evaluation of wide-field (12 × 9 mm) scans on optical coherence tomography imaging. This method was compared to a conventional quantitative analysis of the global circumpapillary retinal nerve fiber layer (cpRNFL) thickness. Methods: A total of 409 eyes with a clinical diagnosis of glaucoma or suspected glaucoma for which two wide-field scans were obtained at least 1 year apart ( n = 125) and within one session ( n = 284) were included to determine the sensitivity of detecting progression at 95% specificity...
May 2018: Translational Vision Science & Technology
Felix Gonzalez-Lopez, Blas Mompean, Rafael Bilbao-Calabuig, Jorge Vila-Arteaga, Jaime Beltran, Julio Baviera
Purpose: To assess dynamic variations in vault induced by changes in brightness in eyes implanted with phakic collamer intraocular lens (pIOL) with central port for correction of myopia, defining new parameters of vaulting measurement. Methods: We used a noninvasive Fourier-domain swept-source anterior-segment optical coherence tomography (AS-OCT) system to dynamically evaluate the shifts between the pIOL and anterior chamber structures under changing light conditions...
May 2018: Translational Vision Science & Technology
Rose S Tan, Robyn H Guymer, Chi D Luu
Purpose: To determine the intrasession and intersession test-retest repeatability of retinal sensitivity measurements using a dark-adapted chromatic perimeter (DACP). Methods: For intrasession testing, retinal sensitivity within the central 24° for the 505-nm stimulus was measured after 20, 30, and 40 minutes of dark adaptation (DA) and for the 625-nm stimulus was measured after the first and second 505-nm tests. For intersession testing, retinal sensitivity for both stimuli was measured after 30 minutes of DA at baseline and 1 month...
May 2018: Translational Vision Science & Technology
Jan Tode, Elisabeth Richert, Stefan Koinzer, Alexa Klettner, Claus von der Burchard, Ralf Brinkmann, Ralph Lucius, Johann Roider
Purpose: To investigate the effect of thermal stimulation of the retina (TS-R) on Bruch's membrane (BrM) thickness in age-related macular degeneration (AMD) mouse models as a novel concept for the prophylaxis and treatment of dry AMD. Methods: Two knockout AMD mouse models, B6.129P2-Apoetm1Unc /J (ApoE-/-) and B6.129X1-Nfe2I2tm1Ywk /J (NRF2-/-), were chosen. One randomized eye of each mouse in four different groups (two of different age, two of different genotype) of five mice was treated by TS-R (532 nm, 10-ms duration, 50-μm spot size), the fellow eye served as control...
May 2018: Translational Vision Science & Technology
Laura Elizabeth Downie, Algis Jonas Vingrys
Purpose: Elevated intraocular pressure (IOP) is the major modifiable risk factor for the sight-threatening eye disease, glaucoma. We investigated whether oral omega-3 supplements affect IOP in normotensive adults. Methods: We undertook a pooled analysis of data from two double-masked, placebo-controlled randomized trials (Australian New Zealand Clinical Trials Registry, ACTRN12614001019695, ACTRN12615000173594) that investigated the efficacy and safety of oral omega-3 supplementation for treating ocular surface inflammation...
May 2018: Translational Vision Science & Technology
Mirella Telles Salgueiro Barboni, Zsuzsanna Szepessy, Dora Fix Ventura, János Németh
Purpose: To establish fluctuation limits, it was considered that not only overall macular sensitivity but also fluctuations of individual test points in the macula might have clinical value. Methods: Three repeated measurements of microperimetry were performed using the Standard Expert test of Macular Integrity Assessment (MAIA) in healthy subjects ( N = 12, age = 23.8 ± 1.5 years old) and in patients with age-related macular degeneration (AMD) ( N = 11, age = 68...
April 2018: Translational Vision Science & Technology
Minhaj Alam, Taeyoon Son, Devrim Toslak, Jennifer I Lim, Xincheng Yao
Purpose: This study aims to develop a fully automated algorithm for artery-vein (A-V) and arteriole-venule classification and to quantify the effect of hypertension on A-V caliber and tortuosity ratios of nonproliferative diabetic retinopathy (NPDR) patients. Methods: We combine an optical density ratio (ODR) analysis and blood vessel tracking (BVT) algorithm to classify arteries and veins and arterioles and venules. An enhanced blood vessel map and ODR analysis are used to determine the blood vessel source nodes...
April 2018: Translational Vision Science & Technology
(no author information available yet)
[This corrects the article on p. 4 in vol. 7.].
April 2018: Translational Vision Science & Technology
Stephanie Lin, Aleksandra Mihailovic, Sheila K West, Chris A Johnson, David S Friedman, Xiangrong Kong, Pradeep Y Ramulu
Purpose: We characterized vision in glaucoma using seven visual measures, with the goals of determining the dimensionality of vision, and how many and which visual measures best model activity limitation. Methods: We analyzed cross-sectional data from 150 older adults with glaucoma, collecting seven visual measures: integrated visual field (VF) sensitivity, visual acuity, contrast sensitivity (CS), area under the log CS function, color vision, stereoacuity, and visual acuity with noise...
April 2018: Translational Vision Science & Technology
Daniel Rohrbach, Ronald H Silverman, Dan Chun, Harriet O Lloyd, Raksha Urs, Jonathan Mamou
Purpose: Mapping of epithelial thickness (ET) is useful for detection of keratoconus, a disease characterized by corneal thinning and bulging in which epithelial thinning occurs over the apex. In prior clinical studies, optical coherence tomography (OCT) measurements of ET were systematically thinner than those obtained by 40-MHz high-frequency ultrasound (HFU) where a constant speed of sound ( c ) of 1636 m/s was used for all corneal layers. The purpose of this work was to study the acoustic properties, that is, c , acoustic impedance ( Z ), and attenuation ( α ) of the corneal epithelium and stroma independently using a scanning acoustic microscope (SAM) to investigate the discrepancy between OCT and HFU estimates of ET...
April 2018: Translational Vision Science & Technology
Duri Kim, Ushasree Pattamatta, Elizabeth Kelly, Paul R Healey, Nicole Carnt, Hans Zoellner, Andrew J R White
Purpose: We investigate the effect of angiotensin receptor blockade on the migration of human Tenon fibroblasts (HTF), using irbesartan, an angiotensin II receptor type 1 (AT1R) blocker (ARB) as a potential antifibrotic agent in glaucoma filtration surgery. Methods: Confluent HTF cultures were scratched with a 1 mL pipette tip and treated with either irbesartan (10, 50, and 100 μg/mL) or angiotensin II (2 μg/mL). The extent of HTF migration up to 30 hours, and cell number and morphology at 72 hours was evaluated...
April 2018: Translational Vision Science & Technology
S Tammy Hsu, Hesham Gabr, Christian Viehland, Karim Sleiman, Hoan T Ngo, Oscar M Carrasco-Zevallos, Lejla Vajzovic, Ryan P McNabb, Sandra S Stinnett, Joseph A Izatt, Anthony N Kuo, Cynthia A Toth
Purpose: We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. Methods: A MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging an object of known size in model eyes. This method then was applied to subretinal blebs created by injection of diluted triamcinolone...
April 2018: Translational Vision Science & Technology
Hendrik Walther, Chau-Minh Phan, Lakshman N Subbaraman, Lyndon Jones
Purpose: We evaluate the differences in lipid uptake and penetration in daily disposable (DD) contact lenses (CL) using a conventional "in-vial" method compared to a novel in vitro eye model. Methods: The penetration of fluorescently labelled 22-(N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino)-23,24-Bisnor-5-Cholen-3beta-Ol (NBD)-cholesterol on three silicone hydrogel (SH) and four conventional hydrogel (CH) DD CLs were investigated. CLs were incubated for 4 and 12 hours in a vial, containing 3...
April 2018: Translational Vision Science & Technology
Nripun Sredar, Oladipo E Fagbemi, Alfredo Dubra
Purpose: To demonstrate the viability of improving transverse image resolution in reflectance scanning adaptive optics ophthalmoscopy using sub-Airy disk confocal detection. Methods: The foveal cone mosaic was imaged in five human subjects free of known eye disease using two custom adaptive optics scanning light ophthalmoscopes (AOSLOs) in reflectance with 7.75 and 4.30 mm pupil diameters. Confocal pinholes of 0.5, 0.6, 0.8, and 1.0 Airy disk diameters (ADDs) were used in a retinal conjugate plane before the light detector...
April 2018: Translational Vision Science & Technology
Jean-Claude Mwanza, Gary Lee, Donald L Budenz, Joshua L Warren, Michael Wall, Paul H Artes, Thomas M Callan, John G Flanagan
Purpose: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. Methods: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean deviation (MD) greater than -4 decibels (dB), aged 40 to 80 years, and who were enrolled in the Full-Threshold Testing Size III, V, VI comparison study were used in this study...
April 2018: Translational Vision Science & Technology
Yu-Chi Liu, Jiaxin Wen, Ericia Pei Wen Teo, Geraint P Williams, Nyein Chan Lwin, Jodhbir S Mehta
Purpose: To compare the postoperative higher-order-aberrations (HOAs) after hyperopic small incision lenticule extraction (SMILE), hyperopic laser-assisted in situ keratomileusis ( LASIK), and lenticule implantation for correction of hyperopia. Methods: Eighteen monkeys were divided to six groups: +2.00 D and +4.00 D hyperopic SMILE, +2.00 D and +4.00 D hyperopic LASIK ( n = 6 eyes for each), and lenticule implantation with a -2.00 D and -4.00 D lenticule ( n = 3 eyes for each)...
April 2018: Translational Vision Science & Technology
Zhichao Wu, Denis S D Weng, Abinaya Thenappan, Robert Ritch, Donald C Hood
Purpose: To evaluate a manual region-of-interest (ROI) approach for detecting progressive macular ganglion cell complex (GCC) changes on optical coherence tomography (OCT) imaging. Methods: One hundred forty-six eyes with a clinical diagnosis of glaucoma or suspected glaucoma with macular OCT scans obtained at least 1 year apart were evaluated. Changes in the GCC thickness were identified using a manual ROI approach (ROIM ), whereby region(s) of observed or suspected glaucomatous damage were manually identified when using key features from the macular OCT scan on the second visit...
April 2018: Translational Vision Science & Technology
Ian Pitha, Elizabeth C Kimball, Ericka N Oglesby, Mary Ellen Pease, Jie Fu, Julie Schaub, Yoo-Chun Kim, Qi Hu, Justin Hanes, Harry A Quigley
Purpose: To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma. Methods: We injected either DPP or control microparticles intravitreally in rats. Two days later, unilateral ocular hypertension was induced by translimbal, diode laser treatment by a surgeon masked to treatment group. IOP and clinical exams were performed until sacrifice 6 weeks after laser treatment...
April 2018: Translational Vision Science & Technology
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Translational Vision Science & Technology
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