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Translational Vision Science & Technology

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https://www.readbyqxmd.com/read/28097047/quantifying-the-on-and-off-contributions-to-the-flash-erg-with-the-discrete-wavelet-transform
#1
Mathieu Gauvin, Maja Sustar, John M Little, Jelka Brecelj, Jean-Marc Lina, Pierre Lachapelle
PURPOSE: Discrete wavelet transform (DWT) analyses suggest that the 20- and 40-Hz components of the short-flash photopic electroretinogram (ERG) are closely related to the ON and OFF pathways, respectively. With the DWT, we examined how the ERG ON and OFF components are modulated by the stimulus intensity and/or duration. METHODS: Discrete wavelet transform descriptors (20, 40 Hz and 40:20-Hz ratio) were extracted from ERGs evoked to 25 combinations of flash durations (150-5 ms) and strengths (0...
January 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28083446/erratum
#2
(no author information available yet)
[This corrects the article on p. 4 in vol. 5.].
January 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28083445/development-of-absorbable-antibiotic-eluting-sutures-for-ophthalmic-surgery
#3
Fabiana Kashiwabuchi, Kunal S Parikh, Revaz Omiadze, Shuming Zhang, Lixia Luo, Himatkumar V Patel, Qingguo Xu, Laura M Ensign, Hai-Quan Mao, Justin Hanes, Peter J McDonnell
PURPOSE: To develop and evaluate an antibiotic-eluting suture for ophthalmic surgery. METHODS: Wet electrospinning was used to manufacture sutures composed of poly(L-lactide), polyethylene glycol (PEG), and levofloxacin. Size, morphology, and mechanical strength were evaluated via scanning electron microscopy and tensile strength, respectively. In vitro drug release was quantified using high performance liquid chromatography. In vitro suture activity against Staphylococcus epidermidis was investigated through bacterial inhibition studies...
January 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27980879/lower-vitamin-d-level-and-distinct-tear-cytokine-profile-were-observed-in-patients-with-mild-dry-eye-signs-but-exaggerated-symptoms
#4
Rohit Shetty, Swaminathan Sethu, Priyanka Chevour, Kalyani Deshpande, Natasha Pahuja, Harsha Nagaraja, Narendra Pindipapanahalli, Arkasubhra Ghosh
PURPOSE: Dry eye is associated with inflammation, pain, and discomfort. Vitamin D is known to modulate immune responses and pain. This study investigates the level of serum vitamin D and tear-inflammatory proteins with relation to exaggerated symptoms in patients with mild dry eye. METHODS: Patients with mild dry eye signs (Dry Eye Workshop [DEWS] severity grade 1) but with exaggerated symptoms and healthy controls (n = 19, each) were recruited for this cross-sectional study...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27980878/glaucoma-and-driving-risk-under-simulated-fog-conditions
#5
Alberto Diniz-Filho, Erwin R Boer, Ahmed Elhosseiny, Zhichao Wu, Masaki Nakanishi, Felipe A Medeiros
PURPOSE: We evaluate driving risk under simulated fog conditions in glaucoma and healthy subjects. METHODS: This cross-sectional study included 41 glaucoma patients and 25 age-matched healthy subjects who underwent driving simulation. Tests consisted of curve negotiation without and with fog preview at 30 m of distance and two controlled speeds (slow and fast). Inverse time-to-line crossing (invTLC) was used as metric to quantify risk; higher invTLC values indicating higher risk, as less time is available to avoid drifting out of the road...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27980877/suprachoroidal-corticosteroid-administration-a-novel-route-for-local-treatment-of-noninfectious-uveitis
#6
Debra A Goldstein, Diana Do, Glenn Noronha, Jennifer M Kissner, Sunil K Srivastava, Quan D Nguyen
PURPOSE: To evaluate the safety, tolerability, and preliminary efficacy of suprachoroidal injection of triamcinolone acetonide (TA) in patients with noninfectious uveitis. METHODS: In this Phase 1/2 open-label clinical study, a single suprachoroidal injection of 4-mg TA in 100 μL was performed in the study eye of patients with noninfectious intermediate, posterior, or pan-uveitis, and follow-up obtained for 26 weeks. RESULTS: Nine individuals with chronic uveitis were enrolled...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27980876/development-of-a-pediatric-visual-field-test
#7
Marco A Miranda, David B Henson, Cecilia Fenerty, Susmito Biswas, Tariq Aslam
PURPOSE: We describe a pediatric visual field (VF) test based on a computer game where software and hardware combine to provide an enjoyable test experience. METHODS: The test software consists of a platform-based computer game presented to the central VF. A storyline was created around the game as was a structure surrounding the computer monitor to enhance patients' experience. The patient is asked to help the central character collect magic coins (stimuli). To collect these coins a series of obstacles need to be overcome...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27933222/endophthalmitis-prophylaxis-using-a-single-drop-of-thermoresponsive-controlled-release-microspheres-loaded-with-moxifloxacin-in-a-rabbit-model
#8
Alex Mammen, Eric G Romanowski, Morgan V Fedorchak, Deepinder K Dhaliwal, R M Shanks, Regis P Kowalski
PURPOSE: Postsurgical endophthalmitis is a sight-threatening problem. We introduce a simple approach by using a single application of thermoresponsive controlled-release microspheres, loaded with moxifloxacin, to prevent bacterial endophthalmitis in a rabbit endophthalmitis prevention model. METHODS: We separated 24 rabbits into 3 treatment groups in which topical drop treatment was placed onto the conjunctival cul-de-sac: (1) a single drop of controlled-release microspheres containing moxifloxacin, (2) a single drop of controlled-release microspheres without moxifloxacin, and (3) multiple topical treatment with moxifloxacin alone every 15 minutes for 1 hour...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27933221/evaluating-the-biostability-of-yellow-and-clear-intraocular-lenses-with-a-system-simulating-natural-intraocular-environment
#9
Rijo Hayashi, Shimmin Hayashi, Kiyomi Arai, Shinichirou Yoshida, Makoto Chikuda, Shigeki Machida
PURPOSE: Blue light-filtering intraocular lenses (IOLs) are thought to protect the retina from blue light damage after cataract surgery, and the implantation of yellow-tinted IOLs has been commonly used in cataract surgery. To our knowledge, this is the first investigation measuring the long-term biostability of yellow-tinted IOLs using an in vitro system simulating natural intraocular environment. METHODS: Six hydrophobic acrylic IOLs, three clear IOLs, and three yellow-tinted IOLs were included in the study...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27933220/a-novel-method-for-quantitative-serial-autofluorescence-analysis-in-retinitis-pigmentosa-using-image-characteristics
#10
Jasleen K Jolly, Siegfried K Wagner, Jonathan Moules, Florian Gekeler, Andrew R Webster, Susan M Downes, Robert E MacLaren
PURPOSE: Identifying potential biomarkers for disease progression in retinitis pigmentosa (RP) is highly relevant now that gene therapy and other treatments are in clinical trial. Here we report a novel technique for analysis of short-wavelength autofluorescence (AF) imaging to quantify defined regions of AF in RP patients. METHODS: Fifty-five-degree AF images were acquired from 12 participants with RP over a 12-month period. Of these, five were identified as having a hyperfluorescent annulus...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27933219/erratum
#11
(no author information available yet)
[This corrects the article on p. 6 in vol. 5.].
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27933218/erratum
#12
(no author information available yet)
[This corrects the article on p. 6 in vol. 5.].
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27917311/rock-inhibition-promotes-attachment-proliferation-and-wound-closure-in-human-embryonic-stem-cell-derived-retinal-pigmented-epithelium
#13
Roxanne H Croze, William J Thi, Dennis O Clegg
PURPOSE: Nonexudative (dry) age-related macular degeneration (AMD), a leading cause of blindness in the elderly, is associated with the loss of retinal pigmented epithelium (RPE) cells and the development of geographic atrophy, which are areas devoid of RPE cells and photoreceptors. One possible treatment option would be to stimulate RPE attachment and proliferation to replace dying/dysfunctional RPE and bring about wound repair. Clinical trials are underway testing injections of RPE cells derived from pluripotent stem cells to determine their safety and efficacy in treating AMD...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27867756/reference-clinical-database-for-fixation-stability-metrics-in-normal-subjects-measured-with-the-maia-microperimeter
#14
Marco U Morales, Saker Saker, Craig Wilde, Carlo Pellizzari, Aristophanes Pallikaris, Neil Notaroberto, Martin Rubinstein, Chiara Rui, Paolo Limoli, Michael K Smolek, Winfried M Amoaku
PURPOSE: The purpose of this study was to establish a normal reference database for fixation stability measured with the bivariate contour ellipse area (BCEA) in the Macular Integrity Assessment (MAIA) microperimeter. METHODS: Subjects were 358 healthy volunteers who had the MAIA examination. Fixation stability was assessed using two BCEA fixation indices (63% and 95% proportional values) and the percentage of fixation points within 1° and 2° from the fovea (P1 and P2)...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847692/aqueous-angiography-with-fluorescein-and-indocyanine-green-in-bovine-eyes
#15
Alex S Huang, Sindhu Saraswathy, Anna Dastiridou, Alan Begian, Hanz Legaspi, Chirayu Mohindroo, James C H Tan, Brian A Francis, Joseph Caprioli, David R Hinton, Robert N Weinreb
PURPOSE: We characterize aqueous angiography as a real-time aqueous humor outflow imaging (AHO) modality in cow eyes with two tracers of different molecular characteristics. METHODS: Cow enucleated eyes (n = 31) were obtained and perfused with balanced salt solution via a Lewicky AC maintainer through a 1-mm side-port. Fluorescein (2.5%) or indocyanine green (ICG; 0.4%) were introduced intracamerally at 10 mm Hg individually or sequentially. With an angiographer, infrared and fluorescent images were acquired...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847691/a-single-wide-field-oct-protocol-can-provide-compelling-information-for-the-diagnosis-of-early-glaucoma
#16
Donald C Hood, Nicole De Cuir, Dana M Blumberg, Jeffrey M Liebmann, Ravivarn Jarukasetphon, Robert Ritch, Carlos G De Moraes
PURPOSE: To evaluate a report for glaucoma diagnosis based on a single optical coherence tomography (OCT) protocol. METHODS: A wide-field (9 × 12 mm) swept-source (SS) OCT scan, encompassing the macula and disc, was obtained on 130 eyes (patients) with or suspected open-angle glaucoma, a mean deviation greater than or equal to -6 dB on a 24-2 visual field (VF), and spherical refractive error between ± 6 diopters (D). The single-page report contained a circumpapillary retinal nerve fiber layer (cpRNFL) thickness plot; retinal ganglion cell layer and retinal nerve fiber layer (RNFL) thickness and probability plots of the macula and optic nerve; and an enface slab image of the optic nerve...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847690/release-of-moxifloxacin-from-contact-lenses-using-an-in-vitro-eye-model-impact-of-artificial-tear-fluid-composition-and-mechanical-rubbing
#17
Chau-Minh Phan, Magdalena Bajgrowicz-Cieslak, Lakshman N Subbaraman, Lyndon Jones
PURPOSE: The aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) contact lenses (CLs) under various conditions using a novel in vitro eye model. METHODS: Four commercially available DD conventional hydrogel (CH) CLs (nelfilcon A, omafilcon A, etafilcon A, and ocufilcon B) and three silicone hydrogel (SH) CLs (somofilcon A, narafilcon A, and delefilcon A) were evaluated. These lenses were incubated in moxifloxacin for 24 hours...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847689/a-comparison-of-perimetric-results-from-a-tablet-perimeter-and-humphrey-field-analyzer-in-glaucoma-patients
#18
Yu Xiang George Kong, Mingguang He, Jonathan G Crowston, Algis J Vingrys
PURPOSE: To determine the correlation between the perimetric outcomes from perimetry software Melbourne Rapid Fields (MRF) run on an Apple iPad tablet and those from the Humphrey Field Analyzer (HFA). METHODS: The MRF software was designed with features including variable fixation and fast thresholding using Bayes logic. Here, we report a cross-sectional study on 90 eyes from 90 participants: 12 had normal optic nerves and 78 had glaucoma with various degrees of visual field loss (41 mild and 37 moderate-severe)...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847688/significant-glaucomatous-visual-field-progression-in-the-first-two-years-what-does-it-mean
#19
Andrew J Anderson
PURPOSE: It has been recommended that multiple visual field examinations be performed in the first 2 years after glaucoma diagnosis so that rapid visual field progression (≤-2 dB/year, using ordinary least squares regression over time of the summary index mean deviation [MD]) can be detected. Here I investigate how predictive a statistically significant regression slope is of truly rapid visual field progression. METHODS: I simulated visual field series (N = 100,000) spaced at 4 monthly intervals for the first 2 years...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27777828/psychophysical-vision-simulation-of-diffractive-bifocal-and-trifocal-intraocular-lenses
#20
Wolfgang Brezna, Kirsten Lux, Nikolaus Dragostinoff, Christian Krutzler, Nicole Plank, Rainer Tobisch, Agnes Boltz, Gerhard Garhöfer, Reinhard Told, Katarzyna Witkowska, Leopold Schmetterer
PURPOSE: The visual performance of monofocal, bifocal, and trifocal intraocular lenses was evaluated by human individuals using a vision simulator device. This allowed investigation of the visual impression after cataract surgery, without the need actually to implant the lenses. METHODS: The randomized, double-masked, three-way cross-over study was conducted on 60 healthy male and female subjects aged between 18 and 35 years. Visual acuity (Early Treatment Diabetic Retinopathy Study; ETDRS) and contrast sensitivity tests (Pelli-Robson) under different lighting conditions (luminosities from 0...
October 2016: Translational Vision Science & Technology
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