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Translational Vision Science & Technology

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https://www.readbyqxmd.com/read/29321945/gaze-compensation-as-a-technique-for-improving-hand-eye-coordination-in-prosthetic-vision
#1
Samuel A Titchener, Mohit N Shivdasani, James B Fallon, Matthew A Petoe
Purpose: Shifting the region-of-interest within the input image to compensate for gaze shifts ("gaze compensation") may improve hand-eye coordination in visual prostheses that incorporate an external camera. The present study investigated the effects of eye movement on hand-eye coordination under simulated prosthetic vision (SPV), and measured the coordination benefits of gaze compensation. Methods: Seven healthy-sighted subjects performed a target localization-pointing task under SPV...
January 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29302382/beyond-retinal-layers-a-deep-voting-model-for-automated-geographic-atrophy-segmentation-in-sd-oct-images
#2
Zexuan Ji, Qiang Chen, Sijie Niu, Theodore Leng, Daniel L Rubin
Purpose: To automatically and accurately segment geographic atrophy (GA) in spectral-domain optical coherence tomography (SD-OCT) images by constructing a voting system with deep neural networks without the use of retinal layer segmentation. Methods: An automatic GA segmentation method for SD-OCT images based on the deep network was constructed. The structure of the deep network was composed of five layers, including one input layer, three hidden layers, and one output layer...
January 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29285417/agreement-in-cone-density-derived-from-gaze-directed-single-images-versus-wide-field-montage-using-adaptive-optics-flood-illumination-ophthalmoscopy
#3
Avenell L Chew, Danuta M Sampson, Irwin Kashani, Fred K Chen
Purpose: We compared cone density measurements derived from the center of gaze-directed single images with reconstructed wide-field montages using the rtx1 adaptive optics (AO) retinal camera. Methods: A total of 29 eyes from 29 healthy subjects were imaged with the rtx1 camera. Of 20 overlapping AO images acquired, 12 (at 3.2°, 5°, and 7°) were used for calculating gaze-directed cone densities. Wide-field AO montages were reconstructed and cone densities were measured at the corresponding 12 loci as determined by field projection relative to the foveal center aligned to the foveal dip on optical coherence tomography...
December 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29242757/differential-gene-transcription-of-extracellular-matrix-components-in-response-to-in-vivo-corneal-crosslinking-cxl-in-rabbit-corneas
#4
Sabine Kling, Arthur Hammer, Emilio A Torres Netto, Farhad Hafezi
Purpose: We studied changes in gene transcription after corneal crosslinking (CXL) in the rabbit cornea in vivo and identified potential molecular signaling pathways. Methods: A total of 15 corneas of eight male New-Zealand-White rabbits were de-epithelialized and equally divided into five groups. Group 1 served as an untreated control. Groups 2 to 5 were soaked with 0.1% riboflavin for 20 minutes, which in Groups 3 to 5 was followed by UV-A irradiation at a fluence of 5...
December 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29242756/intersession-test-retest-variability-of-microperimetry-in-type-2-macular-telangiectasia
#5
Evan N Wong, Jehan D A De Soyza, David A Mackey, Ian J Constable, Fred K Chen
Purpose: Microperimetry is used as an endpoint in type 2 macular telangiectasia (mactel) trials. The change required for defining disease progression depends on measurement error. We determined the threshold of test-retest variability (TRV) of microperimetry in mactel. Methods: A prospective study was done of 24 patients with stable mactel enrolled in a tertiary eye clinic. Each patient underwent three sessions of microperimetry separated by a median of 28 days...
December 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29134136/creating-a-full-thickness-choroidal-incision-an-ex-vivo-analysis-of-human-and-porcine-tissue-contraction-dynamics
#6
Stephen A LoBue, Norihiro Yamada, Moon Jeong Choi, Timothy W Olsen
Purpose: We hypothesized that the elastic nature of the choroid leads to tissue contraction following a full-thickness, sharp incision. Furthermore, we sought to quantify, measure, and compare tissue contraction in ex vivo porcine globes and human globes of various ages using predetermined variables. Method: A full-thickness, ex vivo choroidal incision was performed in either pig (n = 97) or human (n = 30) specimens. Variables included trephine diameter (1.5, 2...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29134135/polypoidal-choroidal-vasculopathy-on-swept-source-optical-coherence-tomography-angiography-with-variable-interscan-time-analysis
#7
Carl B Rebhun, Eric M Moult, Eduardo A Novais, Carlos Moreira-Neto, Stefan B Ploner, Ricardo N Louzada, ByungKun Lee, Caroline R Baumal, James G Fujimoto, Jay S Duker, Nadia K Waheed, Daniela Ferrara
Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA)...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29134134/predicting-the-real-world-future-of-glaucoma-patients-cautions-are-required-for-machine-learning
#8
Erping Long, Peixing Wan, Yehong Zhuo
No abstract text is available yet for this article.
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29134133/monitoring-and-morphologic-classification-of-pediatric-cataract-using-slit-lamp-adapted-photography
#9
Erping Long, Zhuoling Lin, Jingjing Chen, Zhenzhen Liu, Qianzhong Cao, Haotian Lin, Weirong Chen, Yizhi Liu
Purpose: To investigate the feasibility of pediatric cataract monitoring and morphologic classification using slit lamp-adapted anterior segmental photography in a large cohort that included uncooperative children. Methods: Patients registered in the Childhood Cataract Program of the Chinese Ministry of Health were prospectively selected. Eligible patients underwent slit-lamp adapted anterior segmental photography to record and monitor the morphology of their cataractous lenses...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29109907/a-temporal-white-noise-analysis-for-extracting-the-impulse-response-function-of-the-human-electroretinogram
#10
Andrew J Zele, Beatrix Feigl, Pradeep K Kambhampati, Avinash Aher, Declan McKeefry, Neil Parry, John Maguire, Ian Murray, Jan Kremers
Purpose: We introduce a method for determining the impulse response function (IRF) of the ERG derived from responses to temporal white noise (TWN) stimuli. Methods: This white noise ERG (wnERG) was recorded in participants with normal trichromatic vision to full-field (Ganzfeld) and 39.3° diameter focal stimuli at mesopic and photopic mean luminances and at different TWN contrasts. The IRF was obtained by cross-correlating the TWN stimulus with the wnERG. Results: We show that wnERG recordings are highly repeatable, with good signal-to-noise ratio, and do not lead to blink artifacts...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29090107/optic-disc-image-subtraction-as-an-aid-to-detect-glaucoma-progression
#11
Navid Amini, Reza Alizadeh, Nucharee Parivisutt, EunAh Kim, Kouros Nouri-Mahdavi, Joseph Caprioli
PURPOSE: To present a digital image subtraction technique to alert clinicians to signs of glaucomatous optic disc progression. METHODS: Ninety-two glaucomatous eyes (65 patients) were included. Thirty-three eyes were identified as progressive and 59 as stable based on comparison of baseline and follow-up stereoscopic disc photographs by three masked glaucoma specialists. The disc images were aligned and converted to gray scale and underwent histogram matching to enhance contrast and account for illumination differences...
October 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29082108/goldmann-v-standard-automated-perimetry-underestimates-central-visual-sensitivity-in-glaucomatous-eyes-with-increased-axial-length
#12
Mieko Yanagisawa, Hiroshi Murata, Masato Matsuura, Yuri Fujino, Kazunori Hirasawa, Ryo Asaoka
PURPOSE: To investigate the effect of axial length (AL) on the structure-function relationship between retinal nerve fiber layer (RNFL) thickness measurements and visual field (VF) sensitivity measured with Goldmann III and V. METHOD: There were 85 eyes of 85 patients with primary open angle glaucoma included in the current study. Optical coherence tomography and VF (Humphrey Field Analyzer 24-2 or 30-2) measurements with Goldmann III and V targets were carried out in all patients...
October 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29057163/characterization-of-long-working-distance-optical-coherence-tomography-for-imaging-of-pediatric-retinal-pathology
#13
Ruobing Qian, Oscar M Carrasco-Zevallos, Shwetha Mangalesh, Neeru Sarin, Lejla Vajzovic, Sina Farsiu, Joseph A Izatt, Cynthia A Toth
PURPOSE: We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. METHODS: A prototype swept source OCT system with a LWD (defined as distance from the last optical element of the imaging system to the eye) of 350 mm with custom fixation targets was developed to facilitate imaging of children. Imaging was performed in 49 participants from three age groups: 26 adults, 16 children 13 to 18 years old (teenagers), and seven children under 6 years old (young children) under an approved institutional review board protocol...
October 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29067219/driving-with-hemianopia-v-do-individuals-with-hemianopia-spontaneously-adapt-their-gaze-scanning-to-differing-hazard-detection-demands
#14
Concetta F Alberti, Robert B Goldstein, Eli Peli, Alex R Bowers
PURPOSE: We investigated whether people with homonymous hemianopia (HH) were able to spontaneously (without training or instructions) adapt their blind-side scan magnitudes in response to differing scanning requirements for detection of pedestrians in a driving simulator when differing cues about pedestrian eccentricities and movement behaviors were available in the seeing hemifield. METHODS: Twelve HH participants completed two sessions in a driving simulator pressing the horn when they detected a pedestrian...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29057162/augmenting-endogenous-levels-of-retinal-annexin-a1-suppresses-uveitis-in-mice
#15
Peter J Gardner, Samia Yazid, Joana Ribeiro, Robin R Ali, Andrew D Dick
PURPOSE: The purpose of this study was to examine the expression of the anti-inflammatory protein Annexin A1 (AnxA1) in mice and human retinae during uveitis and to determine whether local administration of human recombinant AnxA1 (hrAnxA1) can suppress uveitis in mice. METHODS: Retinal sections from mice (healthy normal and uveitis) and postmortem human (no history of eye disease (n = 5) and uveitis (n = 7)) were stained for AnxA1 expression and imaged by immunofluorescence microscopy...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29046830/reviewers
#16
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29046829/evaluation-of-a-sustained-release-prednisolone-acetate-biodegradable-subconjunctival-implant-in-a-non-human-primate-model
#17
Yu-Chi Liu, Anthony Herr Cheun Ng, Xu Wen Ng, Peng Yan, Subbu S Venkatraman, Jodhbir S Mehta, Tina T Wong
PURPOSE: We evaluate the toxicity and plasma toxicokinetic (TK) profile of a biodegradable subconjunctival microrod for sustained prednisolone acetate (PA) release over 12 weeks in a non-human primate model. METHODS: The biodegradable copolymer poly(l-lactide-co-ε-caprolactone) (PLC) and 40-wt% PA microrods were used and fashioned into 8 and 16 mm lengths. Twelve monkeys were divided into two treatment groups of PA-loaded and blank microrods, with six monkeys each receiving either 8- or 16-mm microrods subconjunctively implanted into both eyes...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29046828/exploring-test-retest-variability-using-high-resolution-perimetry
#18
Takuya Numata, Ted Maddess, Chota Matsumoto, Sachiko Okuyama, Shigeki Hashimoto, Hiroki Nomoto, Yoshikazu Shimomura
PURPOSE: Test-retest variability (TRV) of visual field (VF) data seriously degrades our capacity to recognize true VF progression. We conducted repeated high-resolution perimetry with a test interval of 0.5° to investigate the sources of TRV. In particular, we examined whether the spatial variance of the observed sensitivity changes or if their absolute magnitude was of more importance. METHODS: Sixteen eyes of 16 glaucoma patients were each tested three times at 61 VF locations along the superior-temporal 45° meridian using a modified protocol of the Octopus 900 perimeter...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29046827/the-importance-of-reviewers
#19
EDITORIAL
Marco Zarbin
No abstract text is available yet for this article.
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28920007/towards-treatment-of-stargardt-disease-workshop-organized-and-sponsored-by-the-foundation-fighting-blindness
#20
REVIEW
Avery E Sears, Paul S Bernstein, Artur V Cideciyan, Carel Hoyng, Peter Charbel Issa, Krzysztof Palczewski, Philip J Rosenfeld, SriniVas Sadda, Ulrich Schraermeyer, Janet R Sparrow, Ilyas Washington, Hendrik P N Scholl
Accumulation of fluorescent metabolic byproducts of the visual (retinoid) cycle is associated with photoreceptor and retinal pigment epithelial cell death in both Stargardt disease and atrophic (nonneovascular) age-related macular degeneration (AMD). As a consequence of this observation, small molecular inhibitors of enzymes in the visual cycle were recently tested in clinical trials as a strategy to protect the retina and retinal pigment epithelium in patients with atrophic AMD. To address the clinical translational needs for therapies aimed at both diseases, a workshop organized by the Foundation Fighting Blindness was hosted by the Department of Pharmacology at Case Western Reserve University on February 17, 2017, at the Tinkham Veale University Center, Cleveland, OH, USA...
September 2017: Translational Vision Science & Technology
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