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Translational Vision Science & Technology

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https://www.readbyqxmd.com/read/27867756/reference-clinical-database-for-fixation-stability-metrics-in-normal-subjects-measured-with-the-maia-microperimeter
#1
Marco U Morales, Saker Saker, Craig Wilde, Carlo Pellizzari, Aristophanes Pallikaris, Neil Notaroberto, Martin Rubinstein, Chiara Rui, Paolo Limoli, Michael K Smolek, Winfried M Amoaku
PURPOSE: The purpose of this study was to establish a normal reference database for fixation stability measured with the bivariate contour ellipse area (BCEA) in the Macular Integrity Assessment (MAIA) microperimeter. METHODS: Subjects were 358 healthy volunteers who had the MAIA examination. Fixation stability was assessed using two BCEA fixation indices (63% and 95% proportional values) and the percentage of fixation points within 1° and 2° from the fovea (P1 and P2)...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847692/aqueous-angiography-with-fluorescein-and-indocyanine-green-in-bovine-eyes
#2
Alex S Huang, Sindhu Saraswathy, Anna Dastiridou, Alan Begian, Hanz Legaspi, Chirayu Mohindroo, James C H Tan, Brian A Francis, Joseph Caprioli, David R Hinton, Robert N Weinreb
PURPOSE: We characterize aqueous angiography as a real-time aqueous humor outflow imaging (AHO) modality in cow eyes with two tracers of different molecular characteristics. METHODS: Cow enucleated eyes (n = 31) were obtained and perfused with balanced salt solution via a Lewicky AC maintainer through a 1-mm side-port. Fluorescein (2.5%) or indocyanine green (ICG; 0.4%) were introduced intracamerally at 10 mm Hg individually or sequentially. With an angiographer, infrared and fluorescent images were acquired...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847691/a-single-wide-field-oct-protocol-can-provide-compelling-information-for-the-diagnosis-of-early-glaucoma
#3
Donald C Hood, Nicole De Cuir, Dana M Blumberg, Jeffrey M Liebmann, Ravivarn Jarukasetphon, Robert Ritch, Carlos G De Moraes
PURPOSE: To evaluate a report for glaucoma diagnosis based on a single optical coherence tomography (OCT) protocol. METHODS: A wide-field (9 × 12 mm) swept-source (SS) OCT scan, encompassing the macula and disc, was obtained on 130 eyes (patients) with or suspected open-angle glaucoma, a mean deviation greater than or equal to -6 dB on a 24-2 visual field (VF), and spherical refractive error between ± 6 diopters (D). The single-page report contained a circumpapillary retinal nerve fiber layer (cpRNFL) thickness plot; retinal ganglion cell layer and retinal nerve fiber layer (RNFL) thickness and probability plots of the macula and optic nerve; and an enface slab image of the optic nerve...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847690/release-of-moxifloxacin-from-contact-lenses-using-an-in-vitro-eye-model-impact-of-artificial-tear-fluid-composition-and-mechanical-rubbing
#4
Chau-Minh Phan, Magdalena Bajgrowicz-Cieslak, Lakshman N Subbaraman, Lyndon Jones
PURPOSE: The aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) contact lenses (CLs) under various conditions using a novel in vitro eye model. METHODS: Four commercially available DD conventional hydrogel (CH) CLs (nelfilcon A, omafilcon A, etafilcon A, and ocufilcon B) and three silicone hydrogel (SH) CLs (somofilcon A, narafilcon A, and delefilcon A) were evaluated. These lenses were incubated in moxifloxacin for 24 hours...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847689/a-comparison-of-perimetric-results-from-a-tablet-perimeter-and-humphrey-field-analyzer-in-glaucoma-patients
#5
Yu Xiang George Kong, Mingguang He, Jonathan G Crowston, Algis J Vingrys
PURPOSE: To determine the correlation between the perimetric outcomes from perimetry software Melbourne Rapid Fields (MRF) run on an Apple iPad tablet and those from the Humphrey Field Analyzer (HFA). METHODS: The MRF software was designed with features including variable fixation and fast thresholding using Bayes logic. Here, we report a cross-sectional study on 90 eyes from 90 participants: 12 had normal optic nerves and 78 had glaucoma with various degrees of visual field loss (41 mild and 37 moderate-severe)...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27847688/significant-glaucomatous-visual-field-progression-in-the-first-two-years-what-does-it-mean
#6
Andrew J Anderson
PURPOSE: It has been recommended that multiple visual field examinations be performed in the first 2 years after glaucoma diagnosis so that rapid visual field progression (≤-2 dB/year, using ordinary least squares regression over time of the summary index mean deviation [MD]) can be detected. Here I investigate how predictive a statistically significant regression slope is of truly rapid visual field progression. METHODS: I simulated visual field series (N = 100,000) spaced at 4 monthly intervals for the first 2 years...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27777828/psychophysical-vision-simulation-of-diffractive-bifocal-and-trifocal-intraocular-lenses
#7
Wolfgang Brezna, Kirsten Lux, Nikolaus Dragostinoff, Christian Krutzler, Nicole Plank, Rainer Tobisch, Agnes Boltz, Gerhard Garhöfer, Reinhard Told, Katarzyna Witkowska, Leopold Schmetterer
PURPOSE: The visual performance of monofocal, bifocal, and trifocal intraocular lenses was evaluated by human individuals using a vision simulator device. This allowed investigation of the visual impression after cataract surgery, without the need actually to implant the lenses. METHODS: The randomized, double-masked, three-way cross-over study was conducted on 60 healthy male and female subjects aged between 18 and 35 years. Visual acuity (Early Treatment Diabetic Retinopathy Study; ETDRS) and contrast sensitivity tests (Pelli-Robson) under different lighting conditions (luminosities from 0...
October 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27777827/quantitative-evaluation-of-microdistortions-in-bowman-s-layer-and-corneal-deformation-after-small-incision-lenticule-extraction
#8
Rushad Shroff, Mathew Francis, Natasha Pahuja, Leio Veeboy, Rohit Shetty, Abhijit Sinha Roy
PURPOSE: To quantitatively evaluate microdistortions in Bowman's layer and change in corneal stiffness after small incision lenticule extraction (SMILE). METHODS: This was a prospective, longitudinal, and interventional study. Thirty eyes of 30 patients were screened preoperatively and underwent SMILE for treatment of myopia with astigmatism. Visual acuity, refraction, optical coherence tomography (OCT; Bioptigen, Inc., Morrisville, NC) imaging of the layer and air-puff applanation (Corvis-ST, OCULUS Optikgeräte Gmbh, Germany) was performed before and after surgery (1 day, 1 week, and 1 month)...
October 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27752402/comparison-of-common-retinal-vessel-caliber-measurement-software-and-a-conversion-algorithm
#9
WanFen Yip, Yih Chung Tham, Wynne Hsu, Mong Li Lee, Ronald Klein, Barbara Klein, Mohammad Kamran Ikram, Tien Yin Wong, Carol Yim-Lui Cheung
PURPOSE: To compare three commonly used retinal vessel caliber measurement software systems, and propose an algorithm for conversion between measurement systems. METHODS: We used 120 retinal photographs to evaluate the agreement between three commonly used software (Retinal Analysis [RA], Integrative Vessel Analysis [IVAN], and Singapore I Vessel Assessment [SIVA]). Bland-Altman plots were used to evaluate agreement of retinal arteriolar (central retinal artery equivalent, CRAE) and venular (central retinal vein equivalent, CRVE) calibers...
October 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27730010/test-retest-variability-of-functional-and-structural-parameters-in-patients-with-stargardt-disease-participating-in-the-sar422459-gene-therapy-trial
#10
Maria A Parker, Dongseok Choi, Laura R Erker, Mark E Pennesi, Paul Yang, Elvira N Chegarnov, Peter N Steinkamp, Catherine L Schlechter, Claire-Marie Dhaenens, Saddek Mohand-Said, Isabelle Audo, Jose Sahel, Richard G Weleber, David J Wilson
PURPOSE: The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy clinical trial. METHODS: Twenty-two participants, aged 24 to 66, diagnosed with advanced forms of STGD, with at least one pathogenic ABCA4 mutation on each chromosome participating in the SAR422459 (NCT01367444) gene therapy clinical trial, were screened over three visits within 3 weeks or less...
October 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27730009/an-endovascular-cannulation-needle-with-an-internal-wire-for-the-fragmentation-of-thrombi-in-retinal-vein-occlusion
#11
Tetsu Asami, Hiroki Kaneko, Kensaku Miyake, Ichiro Ota, Goichiro Miyake, Seiichi Kato, Shunsuke Yasuda, Takeshi Iwase, Yasuki Ito, Hiroko Terasaki
PURPOSE: We report a newly developed device to fragment thrombi in retinal vein occlusion. METHODS: The new instrument consists of a 23-gauge (G) pipe and a 37-G needle with an internal wire. A total of 40 porcine eyes were used; 20 eyes for experiments in the branch retinal vein (BRV group) and 20 eyes for experiments in the central retinal vein (CRV group). We placed 25-G 3-port trocars, and core vitrectomy was performed. Another 23-G scleral incision was performed for insertion of the needle...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27730008/the-cambridge-face-tracker-accurate-low-cost-measurement-of-head-posture-using-computer-vision-and-face-recognition-software
#12
Peter B M Thomas, Tadas Baltrušaitis, Peter Robinson, Anthony J Vivian
PURPOSE: We validate a video-based method of head posture measurement. METHODS: The Cambridge Face Tracker uses neural networks (constrained local neural fields) to recognize facial features in video. The relative position of these facial features is used to calculate head posture. First, we assess the accuracy of this approach against videos in three research databases where each frame is tagged with a precisely measured head posture. Second, we compare our method to a commercially available mechanical device, the Cervical Range of Motion device: four subjects each adopted 43 distinct head postures that were measured using both methods...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27730007/a-fast-and-efficient-technique-for-the-automatic-tracing-of-corneal-nerves-in-confocal-microscopy
#13
Pedro Guimarães, Jeffrey Wigdahl, Alfredo Ruggeri
PURPOSE: We describe a novel fully automatic method capable of tracing the subbasal plexus nerves from human corneal confocal images. METHODS: Following an increasing interest in the automatic analysis of corneal nerves, a few approaches have been proposed. These, however, cannot cope with large images, such as mosaics, in due time. The rationale of the proposed method is to minimize required computing time while still providing accurate results. Our method consists of two sequential steps - a thresholding step followed by a supervised classification...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27668130/the-accuracy-and-reliability-of-crowdsource-annotations-of-digital-retinal-images
#14
Danny Mitry, Kris Zutis, Baljean Dhillon, Tunde Peto, Shabina Hayat, Kay-Tee Khaw, James E Morgan, Wendy Moncur, Emanuele Trucco, Paul J Foster
PURPOSE: Crowdsourcing is based on outsourcing computationally intensive tasks to numerous individuals in the online community who have no formal training. Our aim was to develop a novel online tool designed to facilitate large-scale annotation of digital retinal images, and to assess the accuracy of crowdsource grading using this tool, comparing it to expert classification. METHODS: We used 100 retinal fundus photograph images with predetermined disease criteria selected by two experts from a large cohort study...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27642541/bioptic-telescope-use-and-driving-patterns-of-drivers-with-age-related-macular-degeneration
#15
Alex R Bowers, Sarah S Sheldon, Dawn K DeCarlo, Eli Peli
PURPOSE: To investigate the telescope use and driving patterns of bioptic drivers with age-related macular degeneration (AMD). METHODS: A questionnaire addressing telescope use and driving patterns was administered by telephone interview to three groups of bioptic drivers: AMD (n = 31; median 76 years); non-AMD first licensed with a bioptic (n = 38; 53 years); and non-AMD first licensed without a bioptic (n = 47; 37 years). Driving patterns of bioptic AMD drivers were also compared with those of normal vision (NV) drivers (n = 36; 74 years) and nonbioptic AMD drivers (n = 34; 79 years)...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27642540/goldmann-tonometer-prism-with-an-optimized-error-correcting-applanation-surface
#16
Sean McCafferty, Garrett Lim, William Duncan, Eniko Enikov, Jim Schwiegerling
PURPOSE: We evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics. METHODS: A modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the intraocular pressure (IOP) error due to corneal thickness, stiffness, curvature, and tear film. Mathematical modeling with finite element analysis (FEA) and manometric IOP referenced cadaver eyes were used to optimize and validate the design...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27642539/enhancement-of-corneal-visibility-in-optical-coherence-tomography-images-with-corneal-opacification
#17
Cheuk Wang Chung, Marcus Ang, Mohamed Farook, Nicholas G Strouthidis, Joddhbir S Mehta, Jean Martial Mari, Michaël J A Girard
PURPOSE: To establish and to rank the performance of a corneal adaptive compensation (CAC) algorithm in enhancing corneal images with scars acquired from three commercially available anterior segment optical coherence tomography (ASOCT) devices. METHODS: Horizontal B-scans of the cornea were acquired from 10 patients using three ASOCT devices (Spectralis, RTVue, and Cirrus). We compared ASOCT image quality (with and without CAC) by computing the intralayer contrast (a measure of shadow removal), the interlayer contrast (a measure of tissue boundary visibility), and the tissue/background contrast (a measure of overall corneal visibility)...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27622081/genetic-testing-as-a-new-standard-for-clinical-diagnosis-of-color-vision-deficiencies
#18
Candice Davidoff, Maureen Neitz, Jay Neitz
PURPOSE: The genetics underlying inherited color vision deficiencies is well understood: causative mutations change the copy number or sequence of the long (L), middle (M), or short (S) wavelength sensitive cone opsin genes. This study evaluated the potential of opsin gene analyses for use in clinical diagnosis of color vision defects. METHODS: We tested 1872 human subjects using direct sequencing of opsin genes and a novel genetic assay that characterizes single nucleotide polymorphisms (SNPs) using the MassArray system...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27622080/assessing-the-goanna-visual-field-algorithm-using-artificial-scotoma-generation-on-human-observers
#19
Luke X Chong, Andrew Turpin, Allison M McKendrick
PURPOSE: To validate the performance of a new perimetric algorithm (Gradient-Oriented Automated Natural Neighbor Approach; GOANNA) in humans using a novel combination of computer simulation and human testing, which we call Artificial Scotoma Generation (ASG). METHODS: Fifteen healthy observers were recruited. Baseline conventional automated perimetry was performed on the Octopus 900. Visual field sensitivity was measured using two different procedures: GOANNA and Zippy Estimation by Sequential Testing (ZEST)...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27622079/a-statistical-model-to-analyze-clinician-expert-consensus-on-glaucoma-progression-using-spatially-correlated-visual-field-data
#20
Joshua L Warren, Jean-Claude Mwanza, Angelo P Tanna, Donald L Budenz
PURPOSE: We developed a statistical model to improve the detection of glaucomatous visual field (VF) progression as defined by the consensus of expert clinicians. METHODS: We developed new methodology in the Bayesian setting to properly model the progression status of a patient (as determined by a group of expert clinicians) as a function of changes in spatially correlated sensitivities at each VF location jointly. We used a spatial probit regression model that jointly incorporates all highly correlated VF changes in a single framework while accounting for structural similarities between neighboring VF regions...
August 2016: Translational Vision Science & Technology
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