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Translational Vision Science & Technology

Antoine Herbaut, Hong Liang, Ghislaine Rabut, Liem Trinh, Karima Kessal, Christophe Baudouin, Antoine Labbé
Purpose: We evaluated the relationship between ocular surface clinical tests and quality of vision in patients with dry eye disease (DED). Methods: In this study, 136 eyes of 72 dry eye patients were evaluated retrospectively using the ocular surface disease index (OSDI), measurement of tear film break-up time (TBUT), the Oxford score, Van Bijsterveld score, and Schirmer I test. Quality of vision was assessed with the optical quality analysis system (OQAS) using the objective scatter index (OSI) recorded over 20 seconds without blinking...
July 2018: Translational Vision Science & Technology
Brian D Krawitz, Erika Phillips, Richard D Bavier, Shelley Mo, Joseph Carroll, Richard B Rosen, Toco Y P Chui
Purpose: To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods: Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with nonproliferative diabetic retinopathy (NPDR), and 15 with proliferative diabetic retinopathy (PDR) were imaged with 10 macular OCTA scans. PICAs were automatically delineated on the averaged superficial OCTA images...
July 2018: Translational Vision Science & Technology
Hiroyuki Sasano, Akira Obana, Mohsen Sharifzadeh, Paul S Bernstein, Shigetoshi Okazaki, Yuko Gohto, Takahiko Seto, Werner Gellermann
Purpose: To demonstrate the presence of macular pigment in the retina of premature infants, and to examine its changes with age. Methods: The participants included 40 premature infants. Infants who had received laser photocoagulation for retinopathy of prematurity were excluded. Macular pigment optical density (MPOD) was measured by fundus reflectometry using RetCam3, a digital fundus camera. The reflection imaging was performed for ROP screening. The imaging time points were from a post menstrual age (PMA) of 29 weeks 0 days to 46 weeks 5 days...
July 2018: Translational Vision Science & Technology
Peter M Maloca, J Emanuel Ramos de Carvalho, Tjebo Heeren, Pascal W Hasler, Faisal Mushtaq, Mark Mon-Williams, Hendrik P N Scholl, Konstantinos Balaskas, Catherine Egan, Adnan Tufail, Lilian Witthauer, Philippe C Cattin
Purpose: Feasibility testing of a novel volume renders technology to display optical coherence tomography data (OCT) in a virtual reality (VR) environment. Methods: A VR program was written in C++/OpenGL to import and display volumetric OCT data in real time with 180 frames per second using a high-end computer and a tethered head-mounted display. Following exposure, participants completed a Simulator Sickness Questionnaire (SSQ) to assess for nausea, disorientation, and oculomotor disturbances...
July 2018: Translational Vision Science & Technology
Derek Nankivil, Alex Gonzalez, Cornelis Rowaan, William Lee, Mariela C Aguilar, Jean-Marie A Parel
Purpose: Our purpose was to develop a robotic remotely operated stereo slit lamp system allowing three-dimensional stereo viewing and recording of the patient's examination via local area network, Internet, and satellite. Methods: A commercial slit lamp was modified to accept motors and servos to permit control of all optical and mechanical components of the device. The custom graphical user interface with dual high-resolution real-time stereoscopic imaging, control/position indicators, overview video, and audio were transmitted via local area network, Internet, and satellite...
July 2018: Translational Vision Science & Technology
Zhichao Wu, Felipe A Medeiros
Purpose: To develop a new visual field simulation model that can recreate real-world longitudinal results at a point-wise level from a clinical glaucoma cohort. Methods: A cohort of 367 glaucoma eyes from 265 participants seen over 10.1 ± 2.5 years were included to obtain estimates of "true" longitudinal visual field point-wise sensitivity and estimates of measurement variability. These two components were then combined to reconstruct visual field results in a manner that accounted for correlated measurement error...
June 2018: Translational Vision Science & Technology
Jessica I W Morgan, Grace K Vergilio, Jessica Hsu, Alfredo Dubra, Robert F Cooper
Purpose: Recent advances in adaptive optics scanning light ophthalmoscopy (AOSLO) have enabled visualization of cone inner segments through nonconfocal split-detection, in addition to rod and cone outer segments revealed by confocal reflectance. Here, we examined the interobserver reliability of cone density measurements in both AOSLO imaging modalities. Methods: Five normal subjects (nine eyes) were imaged along the horizontal and vertical meridians using a custom AOSLO with confocal and nonconfocal split-detection modalities...
June 2018: Translational Vision Science & Technology
Karl M Andersen, Lydia Sauer, Rebekah H Gensure, Martin Hammer, Paul S Bernstein
Purpose: We investigated fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa (RP) using fluorescence lifetime imaging ophthalmoscopy (FLIO). Methods: A total of 33 patients (mean age, 40.0 ± 17.0 years) with RP and an age-matched healthy group were included. The Heidelberg FLIO was used to detect FAF decays in short (SSC; 498-560 nm) and long (LSC; 560-720 nm) spectral channels. We investigated a 30° retinal field and calculated the amplitude-weighted mean fluorescence lifetime (τm )...
June 2018: Translational Vision Science & Technology
Nikhil S Choudhari, Swathi Vallabh Badakere, Ashutosh Richhariya, Sai Naga Sri Harsha Chittajallu, Sirisha Senthil, Chandra Sekhar Garudadri
Purpose: To investigate the mechanism of action and consistency in flow characteristics of the Ahmed glaucoma valve (AGV) under simulated physiological conditions in-vitro and to evaluate whether resistance during priming has any effect on performance of the device. Methods: Each newly opened AGV device was connected to a digital manometer and was primed with normal saline. The device was then placed in a saline bath and connected to an open manometer, a digital manometer, and an infusion pump...
June 2018: Translational Vision Science & Technology
Angela M Brown, Faustina Ottie Opoku, Michael R Stenger
Purpose: This research was prospectively designed to determine whether a 0.083 cycles per degree (cy/deg) (20/7200) square-wave stimulus is a good choice for clinical measurement of newborn infants' contrast sensitivity and whether the contrast sensitivity function (CSF) of the newborn infant is band-pass. The results were retrospectively analyzed to determine whether the method of constant stimuli (MCS) and the descending method of limits (dLIM) yielded similar results. Methods: In across-subjects experimental designs, a pilot experiment used MCS ( N = 47 visual acuity; N = 38 contrast sensitivity at 0...
June 2018: Translational Vision Science & Technology
Jack Phu, Sieu K Khuu, Bang V Bui, Michael Kalloniatis
Purpose: To predict the lead time (difference in time taken for a visual field [VF] defect to be detected) obtained when using stimulus sizes within or near the size of the critical area of spatial summation (Ac), and to test these predictions using sensitivity measurements from a cohort of glaucoma patients. Methods: Thirty-seven patients with early open-angle glaucoma and 60 healthy observers underwent VF testing on the Humphrey Field Analyzer in full threshold mode using Goldmann stimulus sizes I to V (GI-V) across the 30-2 test grid...
May 2018: Translational Vision Science & Technology
Xiaoqi Geng, Xiaoyu Liu, Wei Wei, Yawei Wang, Lizhen Wang, Kinon Chen, Hongqiang Huo, Yuanjie Zhu, Yubo Fan
Purpose: To evaluate retinal damage as the result of craniomaxillofacial trauma and explain its pathogenic mechanism using finite element (FE) simulation. Methods: Computed tomography (CT) images of an adult man were obtained to construct a FE skull model. A FE skin model was built to cover the outer surface of the skull model. A previously validated FE right eye model was symmetrically copied to create a FE left eye model, and both eye models were assembled to the skull model...
May 2018: Translational Vision Science & Technology
Rosa Gutierrez-Bonet, Jorge Ruiz-Medrano, Pablo Peña-Garcia, Muriel Catanese, Yalda Sadeghi, Katayoon Hashemi, Eric Gabison, José M Ruiz-Moreno
Purpose: To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT). Methods: This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations...
May 2018: Translational Vision Science & Technology
Katarzyna Konieczka, Andreas Schoetzau, Simone Koch, Daniela Hauenstein, Josef Flammer
Purpose: The aim of the study was to establish a standardized quantitative evaluation of corneal temperature (CT) that includes anchoring reference points in the topography and minimization of artifacts. We further investigated the distribution and the short- and long-term reproducibility of the CT values, as well as the influence of the core temperatures. Methods: The CT values in both eyes of 40 healthy subjects were measured through thermography. These examinations took place over the course of four visits within 2 consecutive weeks...
May 2018: Translational Vision Science & Technology
Margaret R Strampe, Alison L Huckenpahler, Brian P Higgins, Sergey Tarima, Alexis Visotcky, Kimberly E Stepien, Christine N Kay, Joseph Carroll
Purpose: To examine repeatability and reproducibility of ellipsoid zone (EZ) width measurements in patients with retinitis pigmentosa (RP) using a longitudinal reflectivity profile (LRP) analysis. Methods: We examined Bioptigen optical coherence tomography (OCT) scans from 48 subjects with RP or Usher syndrome. Nominal scan lengths were 6, 7, or 10 mm, and the lateral scale of each scan was calculated using axial length measurements. LRPs were generated from OCT line scans, and the peak corresponding to EZ was manually identified using ImageJ...
May 2018: Translational Vision Science & Technology
Lapam Panda, Umasankar Barik, Suryasmita Nayak, Biswajit Barik, Gyanaranjan Behera, Ramesh Kekunnaya, Taraprasad Das
Purpose: To evaluate effectiveness of Welch Allyn Spot Vision Screener in detecting refractive error in all age groups and amblyopia risk factors in children in a tribal district of India. Methods: All participants received dry retinoscopy and photorefraction; children also received cycloplegic retinoscopy. Statistical analysis included Bland-Altman and coefficient of determination ( R 2 ). Results: Photoscreener could not elicit a response in 113 adults and 5 children of 580 recruited participants...
May 2018: Translational Vision Science & Technology
Zhichao Wu, Denis S D Weng, Abinaya Thenappan, Rashmi Rajshekhar, Robert Ritch, Donald C Hood
Purpose: Our purpose was to compare the effectiveness of detecting progressive retinal nerve fiber layer (RNFL) thickness changes using widefield scans compared to circumpapillary circle scans derived from optic disc volume scans when using a manual region-of-interest (ROI) approach . Methods: In a prospective observational study, a total of 125 eyes diagnosed clinically with glaucoma or suspected glaucoma that had both widefield (12 × 9 mm) and optic disc (6 × 6 mm) scans obtained at least one year apart were included...
May 2018: Translational Vision Science & Technology
Norman P Blair, Anthony E Felder, Michael R Tan, Mahnaz Shahidi
Purpose: Retinal ischemic injury depends on grade and duration of an ischemic insult. We developed a method to induce ischemic injury in rats permitting: (1) Variable grades of retinal blood flow (F) reduction, (2) controllable duration of F reduction, (3) injury without collateral neural damage, and (4) optical measurements of F and O2 -related factors: O2 delivery (DO2 ), O2 extraction fraction (OEF), and metabolic rate of O2 (MO2 ). Methods: In five anesthetized rats the left common carotid artery (CA) was ligated and the right CA was exposed...
May 2018: Translational Vision Science & Technology
Lauren A Dalvin, Diva R Salomão, Raymond Iezzi, Andrew J Barkmeier
Purpose: We recently reported a clinical association between surgical exposure to the ophthalmic lubricant GenTeal gel and postoperative subconjunctival necrotizing granulomatous inflammation. We used a rabbit model to test our hypothesis that subconjunctival exposure to the carbopol 980 component is responsible for inciting chronic inflammation. Methods: Of eight adult wild-type Dutch belted rabbits, 16 eyes received subconjunctival injections of the following: hydroxypropyl methylcellulose (HPMC) 0...
May 2018: Translational Vision Science & Technology
Scott A Read, Stephen J Vincent, Chuen-Seng Tan, Cheryl Ngo, Michael J Collins, Seang-Mei Saw
Purpose: Myopia is rising in prevalence in many locations, and there is evidence that outdoor light exposure is a major environmental factor playing a role in myopia development. This study examined the patterns of daily light exposure in similarly aged children from two geographic locations (Australia and Singapore) known to exhibit differences in myopia prevalence. Methods: Wearable light sensors were used to assess daily light exposure in 69 Singaporean children aged 8 to 12 years (mean, 9...
May 2018: Translational Vision Science & Technology
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