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Pathogens and Disease

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https://www.readbyqxmd.com/read/28334288/genome-sequencing-and-comparative-analysis-of-three-hypermucoviscous-klebsiella-pneumoniae-strains-isolated-in-russia
#1
Angelina A Kislichkina, Anastasia I Lev, Ekaterina V Komisarova, Nadezhda K Fursova, Vera P Myakinina, Tatiana N Mukhina, Alexander A Bogun, Nikolay V Volozhantsev
The prevalence and characteristics of hypermucoviscous (HV) strains among Klebsiella pneumoniae isolated in Russian hospitals were investigated. The HV strains were accounted for 11% K. pneumoniae isolates collected on the period from 2011 to 2016, and were characterized by belonging to K1, K2, K20 and K57 serotypes. Whole genome sequences (WGSs) of K. pneumoniae HV clinical strains KPi261 (SCPM-O-B-7850) and KPB4010 (SCPM-O-B-7846) belonging to K1 and K2 capsular types, as well as WGSs of K. pneumoniae strain KPM9 (SCPM-O-B-7749) of K20 capsular type isolated from freshwater were completed...
March 9, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334263/pathogenesis-of-meningococcal-purpura-fulminans
#2
H Lécuyer, D Borgel, X Nassif, M Coureuil
Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis. In this review, we discuss the prothrombotic events occurring during meningococcal infection. Moreover, recent data from an experimental mouse model have highlighted the critical role of the meningococcus adhesion to the endothelium in the development of PF lesions, thus opening new therapeutic perspectives...
March 9, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334397/does-post-implementation-vaccine-effectiveness-data-support-pre-implementation-predictions-of-4cmenb-utility
#3
Jamie Findlow, Ray Borrow
Meningococcal serogroup B vaccines have been licensed on the basis of safety and immunogenicity data without efficacy studies. Establishing the breadth of coverage of these new vaccines has proved difficult and relied on correlates of protection such as serum bactericidal antibody and a novel assays such as the Meningococcal Antigen Typing System. The demonstration of the effectiveness of 4CMenB in a reduced infant dose schedule together with detailed phenotypic and genotypic information gained from isolates and sera from cases of invasive MenB disease in vaccine eligible infants will enable a re-evaluation of our knowledge of correlates of protection...
March 8, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334216/deletion-of-mazf-increases-staphylococcus-aureus-biofilm-formation-in-an-ica-dependent-manner
#4
Fuminori Kato, Yusuke Yabuno, Yoshihiro Yamaguchi, Motoyuki Sugai, Masayori Inouye
Toxin-antitoxin (TA) systems are composed of a toxin that inhibits an essential cellular process (e.g., DNA replication, transcription, membrane integrity) and its cognate antitoxin that neutralizes the effect of the toxin. Staphylococcus aureus harbors two types of chromosomally encoded TA systems, namely mazEFsa encoding a UACAU-specific mRNA interferase and two paralogous genes of yefM-yoeBsa encoding a ribosome-dependent endoribonuclease system. However, little is known about the physiological role of MazEFsa and YefM-YoeBsa in S...
March 8, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334198/molecular-mechanisms-involved-in-the-interaction-of-neisseria-meningitidis-with-cells-of-the-human-blood-cerebrospinal-fluid-barrier
#5
Alexandra Schubert-Unkmeir
Neisseria meningitidis is one of the most common aetiological agents of bacterial meningitis, affecting predominantly children and young adults. The interaction of N. meningitidis with human endothelial cells lining blood vessels of the blood-cerebrospinal-fluid barrier (B-CSFB) is critical for meningitis development. In recent decades, there has been a significant increase in understanding of the molecular mechanisms involved in the interaction of N. meningitidis with brain vascular cells. In this review, we will describe how N...
March 3, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334203/innate-immune-recognition-and-inflammation-in-neisseria-meningitidis-infection
#6
Kay Johswich
N. meningitidis (Nme) can cause meningitis and sepsis, diseases which are characterized by an overwhelming inflammatory response. Inflammation is triggered by host pattern recognition receptors (PRRs) which are activated by pathogen associated molecular patterns (PAMPs). Nme contains multiple PAMPs including lipooligosaccharide, peptidoglycan, proteins and metabolites. Various classes of PRRs including Toll-like receptors, NOD-like receptors, C-type lectins, scavenger receptors, pentraxins and others are expressed by the host to respond to any given microbe...
March 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334141/distribution-of-antimicrobial-resistance-determinants-virulence-associated-factors-and-crispr-loci-in-isolates-of-enterococcus-faecalis-from-various-settings-and-genetic-lineages
#7
Iwona Gawryszewska, Katarzyna Malinowska, Alicja Kuch, Dorota Chrobak-Chmiel, Lucja Laniewska-Trokenheim, Waleria Hryniewicz, Ewa Sadowy
Enterococcus faecalis represents an important factor of hospital-associated infections (HAIs). The knowledge on its evolution from a commensal to an opportunistic pathogen is still limited, thus we performed a study to characterize distribution of factors that may contribute to this adaptation. Using a collection obtained from various settings (hospitalized patients, community carriers, animals, fresh food, sewage, water) we investigated differences in antimicrobial susceptibility, distribution of antimicrobial resistance genes, virulence-associated determinants and phenotypes, and CRISPR loci in the context of the clonal relatedness of isolates...
March 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28334088/relapse-re-infection-and-mixed-infections-in-tuberculosis-disease
#8
Amanda McIvor, Hendrik Koornhof, Bavesh Davandra Kana
Tuberculosis (TB) disease can be characterized by genotypic and phenotypic complexity in Mycobacterium tuberculosis bacilli within a single patient. This microbiological heterogeneity has become an area of intense study due its perceived importance in drug tolerance, drug resistance and as a surrogate measure of transmission rates. This review presents a descriptive analysis of research describing the prevalence of mixed strain TB infections in geographically distinct locations. Despite significant variation in disease burden and a rampant HIV-TB co-epidemic, there was no difference in the prevalence range of mixed infections reported in African countries when compared to the rest of the world...
February 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28204474/recombinant-protein-cpsit_0846-induces-protective-immunity-against-chlamydia-psittaci-infection-in-balb-c-mice
#9
O Ran, M X Liang, J Yu, M J Yu, Y Song, Y M Wu
No abstract text is available yet for this article.
February 15, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28204467/the-surface-displayed-chaperones-groel-and-dnak-of-mycoplasma-pneumoniae-interact-with-human-plasminogen-and-components-of-the-extracellular-matrix
#10
Lisa Hagemann, Anne Gründel, Enno Jacobs, Roger Dumke
No abstract text is available yet for this article.
February 15, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28175297/borrelia-primed-and-infected-mice-deficient-of-interleukin-17-develop-arthritis-after-neutralization-of-gamma-interferon
#11
Joseph Kuo, Thomas F Warner, Ronald F Schell
No abstract text is available yet for this article.
February 8, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28175294/mirnas-that-associate-with-conjunctival-inflammation-and-ocular-chlamydia-trachomatis-infection-do-not-predict-progressive-disease
#12
Tamsyn Derrick, Athumani M Ramadhani, Karim Mtengai, Patrick Massae, Matthew J Burton, Martin J Holland
No abstract text is available yet for this article.
February 8, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28175285/the-sum-of-all-defenses-tolerance-resistance
#13
Brooke A Napier, Denise M Monack
No abstract text is available yet for this article.
February 8, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28175274/the-effects-of-cpg-odns-and-chitosan-adjuvants-on-the-elicitation-of-immune-responses-induced-by-the-hiv-1-tat-based-candidate-vaccines-in-mice
#14
Samira Alipour, Atiyeh Mahdavi, Asghar Abdoli
No abstract text is available yet for this article.
February 8, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28158586/antimicrobial-activity-of-lactobacillus-salivarius-and-lactobacillus-fermentum-against-staphylococcus-aureus
#15
Mi-Sun Kang, Hae-Soon Lim, Jong-Suk Oh, You-Jin Lim, Karin Wuertz-Kozak, Janette M Harro, Mark E Shirtliff, Yvonne Achermann
No abstract text is available yet for this article.
February 2, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28158541/cholesterol-uptake-in-the-mouse-aorta-increases-during-chlamydia-pneumoniae-infection
#16
Marie Edvinsson, Jonas Tallkvist, Christina Nyström-Rosander, Nils-Gunnar Ilbäck
No abstract text is available yet for this article.
February 2, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28158534/neisserial-surface-lipoproteins-structure-function-and-biogenesis
#17
Yogesh Hooda, Hyejin E Shin, Thomas J Bateman, Trevor F Moraes
No abstract text is available yet for this article.
February 2, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28158464/activation-dependent-modulation-of-streptococcus-pneumoniae-mediated-death-in-human-lymphocytes
#18
Kristina M Grayson, Lance K Blevins, Melissa B Oliver, David Ornelles, W Edward Swords, Martha A Alexander-Miller
No abstract text is available yet for this article.
February 2, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28158456/the-proline-residue-at-position-319-of-bvgs-is-essential-for-bvgas-activation-in-bordetella-pertussis
#19
Yukihiro Hiramatsu, Shuji Yoshino, Yoshiko Yamamura, Nao Otsuka, Keigo Shibayama, Mineo Watanabe, Kazunari Kamachi
No abstract text is available yet for this article.
February 2, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28158404/escherichia-coli-diseases-in-latin-america-a-one-health-multidisciplinary-approach
#20
Alfredo G Torres
No abstract text is available yet for this article.
February 2, 2017: Pathogens and Disease
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