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Clinical Medicine Insights. Pediatrics

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https://www.readbyqxmd.com/read/29317851/a-review-of-the-factors-associated-with-the-timely-initiation-of-breastfeeding-and-exclusive-breastfeeding-in-the-middle-east
#1
REVIEW
Riyadh A Alzaheb
Background: Breastfeeding supplies all the nutrients that infants need for their healthy development. Breastfeeding practice is multifactorial, and numerous variables influence mothers' decisions and ability to breastfeed. This review identifies the factors potentially affecting the timely initiation of breastfeeding within an hour after birth and exclusive breastfeeding in the first 6 months in Middle Eastern countries. Methods: The Medline, ScienceDirect, and Web of Science databases were keyword-searched for primary studies meeting the following inclusion criteria: (1) publication in the English language between January 2001 and May 2017, (2) original research articles reporting primary data on the factors influencing the timely initiation of breastfeeding and/or exclusive breastfeeding, (3) the use of World Health Organization definitions, and (4) Middle Eastern research contexts...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/29276423/hypoglycemia-when-to-treat
#2
REVIEW
Venkat Reddy Kallem, Aakash Pandita, Girish Gupta
Hypoglycemia is the most common metabolic disorder encountered in neonates. The definition of hypoglycemia as well as its clinical significance and management remain controversial. Most cases of neonatal hypoglycemia are transient, respond readily to treatment, and are associated with an excellent prognosis. Persistent hypoglycemia is more likely to be associated with abnormal endocrine conditions, such as hyperinsulinemia, as well as possible neurologic sequelae. Manifestations of hypoglycemia include seizures which can result in noteworthy neuromorbidity in the long haul...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/29276422/incidence-and-predictors-of-mortality-among-newborns-with-perinatal-asphyxia-a-4-year-prospective-study-of-newborns-delivered-in-health-care-facilities-in-enugu-south-east-nigeria
#3
Uchenna Ekwochi, Nwabueze I Asinobi, Chidiebere DI Osuorah, Ikenna K Ndu, Christian Ifediora, Ogechukwu F Amadi, Chukwunonso C Iheji, Casmir Jg Orjioke, Wilfred O Okenwa, Bernadette Ifeyinwa Okeke
Fatalities from perinatal asphyxia remain high in developing countries, and continually assessing its risk factors will help improve outcomes in these settings. We explored how some identified risk factors predict mortality in asphyxiated newborns, to assist clinicians in prioritizing interventions. This was a 4-year prospective study conducted at the Enugu State University Teaching Hospital, Enugu, Nigeria. All newborns who met the study criteria that were admitted to this facility in this period were enrolled and monitored...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28959122/oral-immunotherapy-with-partially-hydrolyzed-wheat-based-cereals-a-pilot-study
#4
Roger Lauener, Philippe A Eigenmann, Jacqueline Wassenberg, Andreas Jung, Sandra Denery-Papini, Sigrid Sjölander, Sophie Pecquet, Rodolphe Fritsché, Adrian Zuercher, Antoine Wermeille, Massimo Fontanesi, Annick Mercenier, Yvonne M Vissers, Sophie Nutten
To date, only few studies have assessed oral immunotherapy (OIT) for wheat allergy and often describe severe adverse reactions during therapy. We developed partially hydrolyzed wheat-based cereals (pHC), which were used in a multicenter, open-label, OIT pilot study, in immunoglobulin E-mediated wheat allergy children (NCT01332084). The primary objective of the study was to test whether wheat allergic patients tolerate pHC and primary end point was the presence or not of immediate adverse reactions to pHC during the 1-day initial escalation phase (stepwise increased doses of pHC), with evaluation of the maximum dose tolerated...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28781518/spirometry-in-asthma-care-a-review-of-the-trends-and-challenges-in-pediatric-practice
#5
REVIEW
Adaeze C Ayuk, Samuel N Uwaezuoke, Chizalu I Ndukwu, Ikenna K Ndu, Kenechukwu K Iloh, Chinyere V Okoli
BACKGROUND: Given the rising incidence of noncommunicable diseases (NCDs) globally, especially bronchial asthma, there is the need to reduce the associated morbidity and mortality by adopting an objective means of diagnosis and monitoring. AIM: This article aims to review the trends and challenges in the use of spirometry for managing childhood bronchial asthma especially in developing countries. METHODS: We conducted a literature search of published data on the use of spirometry for the diagnosis of childhood bronchial asthma with special emphasis resource-poor countries...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28680270/parents-assessments-of-disability-in-their-children-using-world-health-organization-international-classification-of-functioning-disability-and-health-child-and-youth-version-joined-body-functions-and-activity-codes-related-to-everyday-life
#6
Niels Ove Illum, Kim Oren Gradel
AIM: To help parents assess disability in their own children using World Health Organization (WHO) International Classification of Functioning, Disability and Health, Child and Youth Version (ICF-CY) code qualifier scoring and to assess the validity and reliability of the data sets obtained. METHOD: Parents of 162 children with spina bifida, spinal muscular atrophy, muscular disorders, cerebral palsy, visual impairment, hearing impairment, mental disability, or disability following brain tumours performed scoring for 26 body functions qualifiers (b codes) and activities and participation qualifiers (d codes)...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28579864/evaluation-of-neonatal-transport-in-western-switzerland-a-model-of-perinatal-regionalization
#7
Caitriona Gilleece McEvoy, Emilienne Descloux, Mirjam Schuler Barazzoni, Corinne Stadelmann Diaw, Jean-François Tolsa, Matthias Roth-Kleiner
Neonatal transport is an essential part of regionalization for highly specialized neonatal intensive care. This retrospective analysis of prospectively collected data on neonatal transport activity in a large Swiss perinatal network more than 1 year, aimed to quantify this activity, to identify the needs for staff, and the demands regarding know-how and equipment. Of the 565 admissions to the tertiary neonatology clinic, 176 (31.2%) were outborn patients, transported as emergencies to the level III unit. In 71...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28469521/congenital-hepatic-cyst
#8
Aldo Recinos, Tarik Zahouani, Juan Guillen, Benamanahalli Rajegowda
Congenital hepatic cyst is a rare and nonsymptomatic condition in infants and children. Its incidence is 2.5% in the postnatal life with a much lower incidence in the prenatal period. Incidental finding on antenatal imaging is the most common presentation. We present a case of a newborn in whom fetal ultrasound detected a cyst within the fetal liver. Postnatal imaging revealed a liver cyst in the right lobe of the liver, with no other intrahepatic structure affected. Liver function tests were abnormal, but the patient was asymptomatic...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28469520/association-between-early-idiopathic-neonatal-jaundice-and-urinary-tract-infections
#9
Murat Özcan, S Ümit Sarici, Yüksel Yurdugül, Melis Akpinar, Demet Altun, Begüm Özcan, Muhittin A Serdar, Dilek Sarici
BACKGROUND AND PURPOSE: Etiologic role, incidence, demographic, and response-to-treatment characteristics of urinary tract infection (UTI) among neonates, its relationship with significant neonatal hyperbilirubinemia, and abnormalities of the urinary system were studied in a prospective investigation in early (⩽10 days) idiopathic neonatal jaundice in which all other etiologic factors of neonatal hyperbilirubinemia were ruled out. PATIENTS AND METHODS: Urine samples for microscopic and bacteriologic examination were obtained with bladder catheterization from 155 newborns with early neonatal jaundice...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28469519/factors-influencing-exclusive-breastfeeding-in-tabuk-saudi-arabia
#10
Riyadh A Alzaheb
BACKGROUND: Breast milk contains all the nutrients infants need for their first 6 months of life. However, only a minority of Saudi Arabian mothers exclusively breastfeed, so the influencing factors must be examined to encourage more to do so. The study aimed to determine the prevalence of exclusive breastfeeding at 6 months and its associated factors in Tabuk, North West Saudi Arabia. METHODS: A total of 589 mothers of healthy infants aged between 6 and 24 months were interviewed while attending Well-Baby Clinics within 5 primary health care centers...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28469518/relationship-between-exclusive-breastfeeding-and-lower-risk-of-childhood-obesity-a-narrative-review-of-published-evidence
#11
REVIEW
Samuel N Uwaezuoke, Chizoma I Eneh, Ikenna K Ndu
BACKGROUND: The pattern of infant feeding during the first 1000-day period-from conception to the second birthday-has a significant influence on the child's growth trajectory. The relationship between exclusive breastfeeding and lower risk of childhood obesity has elicited much scientific interest, given the fact that this form of malnutrition is becoming a global epidemic. AIM: This narrative review aims to examine the evidence in the literature linking exclusive breastfeeding with reduction in obesity in children...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28096702/early-benefits-of-a-starter-formula-enriched-in-prebiotics-and-probiotics-on-the-gut-microbiota-of-healthy-infants-born-to-hiv-mothers-a-randomized-double-blind-controlled-trial
#12
Peter Cooper, Keith D Bolton, Sithembiso Velaphi, Nanda de Groot, Shahram Emady-Azar, Sophie Pecquet, Philippe Steenhout
The gut microbiota of infants is shaped by both the mode of delivery and the type of feeding. The gut of vaginally and cesarean-delivered infants is colonized at different rates and with different bacterial species, leading to differences in the gut microbial composition, which may persist up to 6 months. In a multicenter, randomized, controlled, double-blind trial conducted in South Africa, we tested the effect of a formula supplemented with a prebiotic (a mixture of bovine milk-derived oligosaccharides [BMOS] generated from whey permeate and containing galactooligosaccharides and milk oligosaccharides such as 3'- and 6'-sialyllactose) and the probiotic Bifidobacterium animalis subsp...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27980447/a-novel-homozygous-frameshift-mutation-in-exon-2-of-lep-gene-associated-with-severe-obesity-a-case-report
#13
Ashwaq Shukri Altawil, Horia Ahmad Mawlawi, Khalid Ateeq Alghamdi, Faten Fohaid Almijmaj
BACKGROUND: Monogenic obesity is a rare type of obesity caused by a mutation in a single gene. Patients with monogenic obesity may develop early onset of obesity and severe metabolic abnormalities. CASE PRESENTATION: A two-and-half-year-old girl was presented to our clinic because of excessive weight gain and hyperphagia. She was born at full term, by normal vaginal delivery with birth weight of 2.82 kg and no complications during pregnancy. The patient was the second child of two healthy, non-obese Saudis with known consanguinity...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27980446/pediatric-weight-management-program-outcomes-in-a-largely-minority-low-socioeconomic-status-population
#14
Michelle Demeule-Hayes, Matthew W Winters, Elizabeth A Getzoff, Bradley A Schwimmer, Vicky S Rogers, Ann O Scheimann
This article describes the outcomes of a pediatric weight management program for a population primarily composed of minority ethnic groups and those from a lower socioeconomic status group. As these groups are disproportionally affected by pediatric obesity and overweight complicated by higher rates of attrition and poorer response to intervention, it is important that adequate and effective treatment exists for patients in these groups. Further research is needed to analyze the outcomes and attrition in these high-risk populations...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27774001/the-significance-of-the-enteric-microbiome-on-the-development-of-childhood-disease-a-review-of-prebiotic-and-probiotic-therapies-in-disorders-of-childhood
#15
REVIEW
John Slattery, Derrick F MacFabe, Richard E Frye
Recent studies have highlighted the fact that the enteric microbiome, the trillions of microbes that inhabit the human digestive tract, has a significant effect on health and disease. Methods for manipulating the enteric microbiome, particularly through probiotics and microbial ecosystem transplantation, have undergone some study in clinical trials. We review some of the evidence for microbiome alteration in relation to childhood disease and discuss the clinical trials that have examined the manipulation of the microbiome in an effort to prevent or treat childhood disease with a primary focus on probiotics, prebiotics, and/or synbiotics (ie, probiotics + prebiotics)...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27547045/serum-neutrophil-gelatinase-associated-lipocalin-in-infants-and-children-with-sepsis-related-conditions-with-or-without-acute-renal-dysfunction
#16
Mohammed Farouk M Afify, Sheren Esam Maher, Nora Mohamed Ibrahim, Waleed Mahamoud Abd El-Hamied
PURPOSE: To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury (AKI) in sepsis-related conditions and its predictive and prognostic values. PATIENTS AND METHODS: This study included 65 patients, who were clinically evaluated for sepsis, severe sepsis, or septic shock, and 20 apparently healthy served as controls. Patients were divided into two groups: Group I (AKI-sepsis): 65 newly admitted patients diagnosed as sepsis, who were further divided into three subgroups according to the severity: systemic inflammatory response syndrome, severe sepsis, and septic shock, and Group II (control group): 20 apparently healthy subjects matched for age and sex, serum creatinine and serum NGAL concentrations were estimated initially within 24 hours of admission and after 72 hours of admission in all patients and control groups...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27441006/intrauterine-growth-restriction-antenatal-and-postnatal-aspects
#17
REVIEW
Deepak Sharma, Sweta Shastri, Pradeep Sharma
Intrauterine growth restriction (IUGR), a condition that occurs due to various reasons, is an important cause of fetal and neonatal morbidity and mortality. It has been defined as a rate of fetal growth that is less than normal in light of the growth potential of that specific infant. Usually, IUGR and small for gestational age (SGA) are used interchangeably in literature, even though there exist minute differences between them. SGA has been defined as having birth weight less than two standard deviations below the mean or less than the 10th percentile of a population-specific birth weight for specific gestational age...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27429564/one-center-s-guide-to-outpatient-management-of-pediatric-cystic-fibrosis-acute-pulmonary-exacerbation
#18
Corinne A Muirhead, Jillian N Sanford, Benjamin G McCullar, Dawn Nolt, Kelvin D MacDonald
Cystic fibrosis (CF) is a chronic disorder characterized by acute pulmonary exacerbations that comprise increased cough, chest congestion, increased mucus production, shortness of breath, weight loss, and fatigue. Typically, severe episodes are treated in the inpatient setting and include intravenous antimicrobials, airway clearance therapy, and nutritional support. Children with less-severe findings can often be managed as outpatients with oral antimicrobials and increased airway clearance therapy at home without visiting the specialty CF center to begin treatment...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27330338/identification-and-treatment-of-pathophysiological-comorbidities-of-autism-spectrum-disorder-to-achieve-optimal-outcomes
#19
REVIEW
Richard E Frye, Daniel A Rossignol
Despite the fact that the prevalence of autism spectrum disorder (ASD) continues to rise, no effective medical treatments have become standard of care. In this paper we review some of the pathophysiological abnormalities associated with ASD and their potential associated treatments. Overall, there is evidence for some children with ASD being affected by seizure and epilepsy, neurotransmitter dysfunction, sleep disorders, metabolic abnormalities, including abnormalities in folate, cobalamin, tetrahydrobiopterin, carnitine, redox and mitochondrial metabolism, and immune and gastrointestinal disorders...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27279759/universal-pulse-oximetry-screening-for-early-detection-of-critical-congenital-heart-disease
#20
REVIEW
Praveen Kumar
Critical congenital heart disease (CCHD) is a major cause of infant death and morbidity worldwide. An early diagnosis and timely intervention can significantly reduce the likelihood of an adverse outcome. However, studies from the United States and other developed countries have shown that as many as 30%-50% of infants with CCHD are discharged after birth without being identified. This diagnostic gap is likely to be even higher in low-resource countries. Several large randomized trials have shown that the use of universal pulse-oximetry screening (POS) at the time of discharge from birth hospital can help in early diagnosis of these infants...
2016: Clinical Medicine Insights. Pediatrics
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