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Biomaterials Science

Elisa M Ovadia, David W Colby, April M Kloxin
Induced pluripotent stem cells (iPSCs) are of interest for the study of disease, where these cells can be derived from patients and have the potential to be differentiated into any cell type; however, three-dimensional (3D) culture and differentiation of iPSCs within well-defined synthetic matrices for these applications remains limited. Here, we aimed to establish synthetic cell-degradable hydrogels that allow precise presentation of specific biochemical cues for 3D culture of iPSCs with relevance for hypothesis testing and lineage-specific differentiation...
April 20, 2018: Biomaterials Science
Hongqiao Zhou, Changhui Fu, Xiaowei Chen, Longfei Tan, Jie Yu, Qiong Wu, Liuhui Su, Zhongbing Huang, Feng Cao, Xiangling Ren, Jun Ren, Ping Liang, Xianwei Meng
Although microwave (MW) thermal therapy has been widely studied for the treatment of tumors due to its less invasiveness, recurrence of tumors is still observed because of the relatively low bioavailability of MW sensitizers. For enhancing the bioavailability of MW sensitizers, triphenyl phosphate (TPP)-conjugated and doxorubicin (DOX)-loaded porous zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol (PEG), ZrMOF-PEG-TPP@DOX NCs, were prepared as a MW sensitizer with mitochondrial-targeting ability...
April 19, 2018: Biomaterials Science
Xiaolei Gu, Min Qiu, Huanli Sun, Jian Zhang, Liang Cheng, Chao Deng, Zhiyuan Zhong
Despite the great significance of clinically viable nanovehicles, very few of them exhibit stability and high anticancer drug loading with fast intracellular drug release. Herein, we report that polytyrosine nanoparticles (PTNs) self-assembled from poly(ethylene glycol)-b-poly(l-tyrosine) block copolymer enable the ultra-high loading and rapid enzyme-responsive release of doxorubicin (DOX). Notably, PTNs achieve a remarkably high DOX loading of 63.1 wt% likely due to the existence of strong π-π stacking between polytyrosine and DOX, as shown by UV-vis analysis...
April 18, 2018: Biomaterials Science
Daiheon Lee, Joseph P Park, Mi-Young Koh, Pureum Kim, Junhee Lee, Mikyung Shin, Haeshin Lee
Mussel-inspired adhesive coatings on biomedical devices have attracted significant interest due to their unique properties such as substrate independency and high efficiency. The key molecules for mussel-inspired adhesive coatings are catechol and amine groups. Along with the understanding of catechol chemistry, chitosan-catechol has also been developed as a representative mussel-inpired adhesive polymer that contains catechol and amine groups for adhesiveness. Herein, we demonstrated the direct writability of chitosan-catechol as a bioink for 3D printing, one of the additive techniques...
April 18, 2018: Biomaterials Science
Pu Wang, Jinxiu Wang, Haowen Tan, Shanfan Weng, Liying Cheng, Zhipeng Zhou, Shu Wen
One of the major challenges in anticancer therapy is the poor penetration of anticancer drugs into tumors, especially in solid tumors, resulting in decreased therapeutic efficacy in vivo. To solve some of these problems, in this study, a dual-responsive polymeric micellar system has been developed. This system exhibits an ultrasensitive response to the change of pH value from the extracellular environment to the intracellular environment, resulting in micellar swelling in cancer cells via the proton sponge effect...
April 16, 2018: Biomaterials Science
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No abstract text is available yet for this article.
April 16, 2018: Biomaterials Science
Run Lin, Jing Huang, Liya Wang, Yuancheng Li, Malgorzata Lipowska, Hui Wu, Jianyong Yang, Hui Mao
Vascular endothelial growth factor (VEGF) plays a pivotal role in the cascade of development and progression of cancers. Targeting this cancer hallmark is a logical strategy for imaging based cancer detection and monitoring the anti-angiogenesis treatment. Using Bevacizumab (Avastin®), which is a recombinant humanized monoclonal antibody directly against VEGF and an angiogenesis inhibitor, as a targeting ligand, a multimodal VEGF targeted molecular imaging probe was developed by conjugating near infrared dye (NIR830) labeled bevacizumab to magnetic iron oxide nanoparticles (IONP) for optical and magnetic resonance (MR) imaging of cancers over-expressing VEGF...
April 13, 2018: Biomaterials Science
Bin Zheng, Yang Bai, Hongbin Chen, Huizhuo Pan, Wanying Ji, Xiaoqun Gong, Xiaoli Wu, Hanjie Wang, Jin Chang
Tumor-associated macrophages are highly versatile effector cells that have been used to kill tumor cells. Herein, the macrophages as cell-based biocarriers are used for the targeted delivery of photothermal reagents for promoting the efficiency of killing tumor cells by activating the anti-tumor immune response and photothermal therapy (PTT). In this design, macrophages cause the phagocytosis of tumor cells and activate the anti-tumor immune response by secreting plenty of cytokines. Meanwhile, to improve the tumor-killing effect and track the collaborative therapy system in vivo, a novel nanoplatform based on tungsten oxide (W18O49, WO) nanoparticles and fluorescent dyes loaded in polylactic-co-glycolic acid (PLGA) for PTT has been successfully constructed...
April 13, 2018: Biomaterials Science
Rikkert J Nap, Estefania Gonzalez Solveyra, Igal Szleifer
When engineering nanomaterials for application in biological systems, it is important to understand how multivalent ions, such as calcium, affect the structural and chemical properties of polymer-modified nanoconstructs. In this work, a recently developed molecular theory was employed to study the effect of surface curvature on the calcium-induced collapse of end-tethered weak polyelectrolytes. In particular, we focused on cylindrical and spherical nanoparticles coated with poly(acrylic acid) in the presence of different amounts of Ca2+ ions...
April 13, 2018: Biomaterials Science
Surendra H Mahadevegowda, Shuai Hou, Jielin Ma, Damien Keogh, Jianhua Zhang, Asadulla Mallick, Xue-Wei Liu, Hongwei Duan, Mary B Chan-Park
Glycan recognition plays key roles in cell-cell and host-pathogen interactions, stimulating widespread interest in developing multivalent glycoconjugates with superior binding affinity for biological and medical uses. Here, we explore the use of Raman-encoded silver coated gold nanorods (GNRs) as scaffolds to form multivalent glycoconjugates. The plasmonic scaffolds afford high-loading of glycan density and their optical properties offer the possibilities of monitoring and quantitative analysis of glycan recognition...
April 12, 2018: Biomaterials Science
Jingqin Chen, Xueshen Li, Xiaoyang Liu, Huixiang Yan, Zhihua Xie, Zonghai Sheng, Xiaojing Gong, Lidai Wang, Xin Liu, Peng Zhang, Hairong Zheng, Liang Song, Chengbo Liu
Phototheranostic technology based on photoacoustic imaging (PAI) and photothermal therapy (PTT) is emerging as a powerful tool for tumor theranostic applications. For effective tumor eradication, a novel PAI/PTT theranostic nanoagent with an excellent optical absorption and photothermal capability is highly desired. Herein, we present a new PAI/PTT nanohybrid named sMoSe2-ICG NSs by covalently conjugating aminated indocyanine green (ICG) onto a single layer of molybdenum selenide nanosheets (sMoSe2 NSs). We first validate the sMoSe2-ICG NS agent for the PAI and PTT effect in vitro and then use it for highly-sensitive PAI guided highly efficient tumor PTT in vivo...
April 10, 2018: Biomaterials Science
Lucie Bacakova, Marta Vandrovcova, Ivana Kopova, Ivan Jirka
Zeolites are microporous tectosilicates of natural or synthetic origin, which have been extensively used in various technological applications, e.g. as catalysts and as molecular sieves, for separating and sorting various molecules, for water and air purification, including removal of radioactive contaminants, for harvesting waste heat and solar heat energy, for adsorption refrigeration, as detergents, etc. These applications of zeolites were typically related with their porous character, their high adsorption capacity, and their ion exchange properties...
April 9, 2018: Biomaterials Science
Aurélien Tidu, Djida Ghoubay-Benallaoua, Claire Teulon, Sophie Asnacios, Kate Grieve, François Portier, Marie-Claire Schanne-Klein, Vincent Borderie, Gervaise Mosser
This study aimed at controlling both the organization and the transparency of dense collagen scaffolds making use of the lyotropic mesogen properties of collagen. Cholesteric or plywood-like liquid crystal phases were achieved using mixtures of acetic and hydrochloric acids as solvents. The critical pH at which the switch between the two phases occurred was around pH = 3. The use of the two acids led to fibrillated collagen I scaffolds, whose visual aspect ranged from opaque to transparent. Rheological investigations showed that viscoelastic properties of the plywood-like solutions were optimized for molding due to faster recovery...
April 6, 2018: Biomaterials Science
Mian Fu, Chenyu Zhang, Yuxuan Dai, Xue Li, Miaobo Pan, Wenlong Huang, Hai Qian, Liang Ge
Closed-loop glucose-responsive insulin delivery with excellent biocompatibility has the potential to improve the health and quality of life of diabetic patients. Herein, we developed an excellent glucose-responsive insulin delivery system using a pH-sensitive peptide hydrogel loaded with insulin and a glucose-specific enzyme. The designed peptide can be used as a carrier that is loaded with insulin and enzyme via a self-assembly process under physiological conditions. When hyperglycemia is encountered, the enzymatic conversion of glucose into gluconic acid leads to a decrease in the local pH, and the hydrogel is disassembled because of the strong inter- and intramolecular electrostatic repulsions between ornithine (Orn) residues; this is followed by the release of insulin...
April 6, 2018: Biomaterials Science
Chara Simitzi, Pascal Harimech, Syrago Spanou, Christina Lanara, Amelie Heuer-Jungemann, Aleka Manousaki, Costas Fotakis, Anthi Ranella, Antonios G Kanaras, Emmanuel Stratakis
In this work, we report on a novel approach to develop hierarchically-structured cell culture platforms incorporating functionalized gold nanoparticles (AuNPs). In particular, the hierarchical substrates comprise primary pseudo-periodic arrays of silicon microcones combined with a secondary nanoscale pattern of homogeneously deposited AuNPs terminated with bio-functional moieties. AuNPs with various functionalities (i.e. oligopeptides, small molecules and oligomers) were successfully attached onto the microstructures...
April 6, 2018: Biomaterials Science
Hao-Wei Lee, Ya-Chuan Hsiao, Tai-Horng Young, Tsung-Lin Yang
Dysfunctional salivary gland (SG) is an unsolved clinical challenge, which is presented as xerostomia. Cell therapy is a promising treatment for restoring SG function. Salispheres are spheroid cellular organizations derived from SG stem cells. Benefitting from these cellular organizations, SG stem cells can be expanded to regenerate SG. During in vitro culture, the spontaneous reorganization of salispheres may change the features of residing SG stem cells. Therefore, it is imperative to explore ways to maintain the spheroid structure of salispheres during cell expansion in vitro...
April 5, 2018: Biomaterials Science
Liang He, Weiguo Xu, Xiaoqing Wang, Chunxi Wang, Jianxun Ding, Xuesi Chen
Hormotherapy and chemotherapy are still the most important palliative therapeutic approaches for androgen-sensitive prostate cancer (PCa). Recently, the combination of hormotherapy and chemotherapy, namely, chemohormonal therapy has aroused considerable attention. Although synergistic chemohormonal therapy can improve PCa suppression efficacy and prolong the lives of patients, it also leads to severe adverse effects, that is, hormonal tolerance caused by hormotherapy, and leukemia or neutropenia caused by chemotherapy...
April 5, 2018: Biomaterials Science
Yun Seop Kim, Dong Kyung Sung, Won Ho Kong, Hyemin Kim, Sei Kwang Hahn
The proteolytic microenvironment in the wound area reduces the stability and the half-life of growth factors in vivo, making difficult the topical delivery of growth factors. Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells. After the synthesis of HA-EGF conjugates, they were incorporated into a patch-type formulation for the facile topical application and sustained release of EGF...
April 4, 2018: Biomaterials Science
G Hazell, P W May, P Taylor, A H Nobbs, C C Welch, B Su
'Black silicon' (bSi) samples with surfaces covered in nanoneedles of varying length, areal density and sharpness, have been fabricated using a plasma etching process. These nanostructures were then coated with a conformal uniform layer of diamond using hot filament chemical vapour deposition to produce 'black diamond' (bD) surfaces. The effectiveness of these bSi and bD surfaces in killing Gram-negative (E. coli) and Gram-positive (S. gordonii) bacteria was investigated by culturing the bacteria on the surfaces for a set time and then measuring the live-to-dead ratio...
April 3, 2018: Biomaterials Science
Peng Pei, Fan Yang, Jiaxing Liu, Haoran Hu, Xiaoyu Du, Nobutaka Hanagata, Shichang Zhao, Yufang Zhu
A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for cancer therapy. To ensure that the chemotherapeutic drug and photothermal agent can be simultaneously delivered to the tumor site to exert their synergistic effects, a safe and efficient delivery system is needed. Herein, we fabricated doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) using a two-step casting process. Mesoporous silica nanoparticles (MSNs) were used to improve the ICG stability and avoid reducing its PTT efficiency in vivo...
March 29, 2018: Biomaterials Science
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