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Biomaterials Science

Jiaxiao Xue, Zhou Guan, Xingyu Zhu, Jiaping Lin, Chunhua Cai, Xiao Jin, Yongsheng Li, Zhaoyang Ye, Wenjie Zhang, Xinquan Jiang
Nanoparticles (NPs) can be taken up by cells; however, the effects of the structural characteristics of NPs on their cellular internalization have not been well explored. In this work, cellular internalization performances of various NPs including rods with helical surface (helical rods), spheres with stripe-pattern surface (striped spheres), and spheres with smooth surface (smooth spheres) were investigated by a combination of experiments and theoretical simulations. This study focuses on the effects of the size, shape, and surface morphology on their cellular internalization behaviors...
October 18, 2018: Biomaterials Science
Paresh Shrimali, Mathew Peter, Archana Singh, Neha Dalal, Suresh Dakave, Shubhada V Chiplunkar, Prakriti Tayalia
For diseases related to genetic disorders or cancer, many cellular therapies rely on the ex vivo modification of cells for attaining a desired therapeutic effect. The efficacy of such therapies involving the genetic modification of cells relies on the extent of gene expression and subsequent persistence of modified cells when infused into the patient's body. In situ gene delivery implies the manipulation of cells in their in vivo niche such that the effectiveness can be improved by minimizing post manipulation effects like cell death, lack of persistence, etc...
October 18, 2018: Biomaterials Science
Bo Li, Peng Gao, Haoqiang Zhang, Zheng Guo, Yufeng Zheng, Yong Han
Fast degradation of Mg-based implants results in the loss of mechanical integrity and poor osseointegration. Herein, a bilayer-structured coating (termed as HAT), comprising an outer layer of hydroxyapatite (HA) nanorods and an inner layer of pores-sealed MgO with HA/Mg(OH)2, was formed on Mg using plasma electrolytic oxidation and hydrothermal treatment. Osteoimmunomodulation, osseointegration, mechanical integrity, and bone-implant interfacial structure evolution of the HAT-coated Mg were investigated by implantation in rabbit femora, together with Mg coated with plasma electrolytic oxidized porous MgO (termed as PEO0) and bare Mg...
October 17, 2018: Biomaterials Science
Xuewei Wang, Aaron Jolliffe, Benjamin Carr, Qi Zhang, Mark Bilger, Yu Cui, Jianfeng Wu, Xianglong Wang, Mollie Mahoney, Alvaro Rojas-Pena, Mark J Hoenerhoff, Justin Douglas, Robert H Bartlett, Chuanwu Xi, Joseph L Bull, Mark E Meyerhoff
Semi-crystalline thermoplastics are an important class of biomaterials with applications in creating extracorporeal and implantable medical devices. In situ release of nitric oxide (NO) from medical devices can enhance their performance via NO's potent anti-thrombotic, bactericidal, anti-inflammatory, and angiogenic activity. However, NO-releasing semi-crystalline thermoplastic systems are limited and the relationship between polymer crystallinity and NO release profile is unknown. In this paper, the functionalization of poly(ether-block-amide) (PEBA), Nylon 12, and polyurethane tubes, as examples of semi-crystalline polymers, with the NO donor S-nitroso-N-acetylpenicillamine (SNAP) within, is demonstrated via a polymer swelling method...
October 17, 2018: Biomaterials Science
Quan Zhou, Yue Wang, Jiajia Xiang, Ying Piao, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Youqing Shen
Calcium phosphate (CaP) nanoparticles present a class of promising nonviral gene delivery carriers due to their easy-preparation procedure, low toxicity and high transfection efficiency. PEGylated polyanion block copolymer was widely used to control the CaP crystal growth during CaP co-precipitation with therapeutic genes. However, there also exists a competition between the entrapped gene and polyanion in the system, which results in reduced stability and low gene entrapment efficiency. To solve this problem, herein, we demonstrate a non-anion stabilization strategy using a boroxole-containing block polymer, PEG-b-poly(benzoxaborole) (PEG-PBO), which forms pH-responsive boronic ester bonds with ribose rings of siRNA and also excellently adhers to the hydroxyapatite surface of CaP...
October 17, 2018: Biomaterials Science
Xu Wang, Fang-Fang Yang, Li-Ping Zhang, Yan-Ping Huang, Zhao-Sheng Liu
Flotation drug delivery system (FDDS) is recognized as an efficient means to improve the therapeutic efficiency and enhance the drug bioavailability. Herein, we have developed a molecularly imprinted polymer (MIP) against capecitabine (CAP) to fabricate a FDDS by exploiting polyhedral oligomeric silsesquioxane (POSS) and Mobil composition of matter no. 41 (MCM-41) as the codopant. The synergistic effect of POSS and MCM-41 endows MIPs with enhanced imprinting effect and improved mass transfer efficiency. The impacts of the type of dopant, the type of functional monomer, the template/functional monomer ratio and the functional monomer/cross-linker ratio on imprinting effect have been investigated in detail...
October 12, 2018: Biomaterials Science
Xiaozhang Zhang, Gang Zhao, Yuan Cao, Zeeshan Haider, Meng Wang, Jianping Fu
Constructs of magnetic nanocomposite hydrogels microencapsulated with stem cells are of great interest as smart materials for tissue engineering and regenerative medicine. Due to the short shelf life of such biocomposites at an ambient temperature, their long-term storage and banking at cryogenic temperatures are essential for the "off-the-shelf" availability of such biocomposites for widespread clinical applications. However, high-quality cryogenic recovery of stem cell-nanocomposite hydrogel constructs has not yet been achieved due to the damage to cells and/or microstructures of hydrogel constructs caused by ice formation, particularly during warming from cryogenic temperatures...
October 11, 2018: Biomaterials Science
Qian Wang, Jia-Mi Li, Hui Yu, Kai Deng, Wei Zhou, Cai-Xia Wang, Yang Zhang, Kun-Heng Li, Ren-Xi Zhuo, Shi-Wen Huang
Photodynamic therapy (PDT) as an alternative choice of cancer treatment method has attracted increasing attention in the past few decades. A sufficient amount of oxygen is essential for the production of singlet oxygen (1O2) in successful PDT; however, hypoxia is a typical hallmark of cancer, which is one of the most important limitation factors of PDT. To overcome the hypoxic tumour microenvironment and achieve highly efficient photodynamic cancer therapy, herein, a photosensitizer Ce6-loaded fluorinated polymeric micelle (Ce6-PFOC-PEI-M) was constructed via the self-assembly of an amphiphilic polymer prepared from perfluorooctanoic acid and branched polyethyleneimine (10 kDa)...
October 11, 2018: Biomaterials Science
Xueqing Yong, Xuan Yang, Steven R Emory, Jun Wang, Jie Dai, Xiaoya Yu, Ling Mei, Jinbing Xie, Gang Ruan
Targeted delivery of nanomaterials to specific intracellular locations is essential for the development of many nanomaterials-based biological applications. Thus far the targeting performance has been limited due to various intracellular transport barriers, especially intracellular vesicle trapping. Here we report the application of permeation enhancers based on organic solvents in small percentage to enhance the intracellular targeted delivery of nanomaterials. Previously permeation enhancers based on organic solvents and ionic liquids have been used in overcoming biological transport barriers at tissue, organ, and cellular levels, but this strategy has so far rarely been examined for its potential in facilitating transport of nanometer-scale entities across intracellular barriers, particularly intracellular vesicle trapping...
October 10, 2018: Biomaterials Science
Qiong Sun, Chunming Tang, Zhigui Su, Junjie Du, Yunkai Shang, Lingjing Xue, Can Zhang
Cationic lipids and polymers are the most common non-viral vectors for siRNA delivery; however, their intense positively charged character may give rise to serum-triggered aggregation, immune activation, inflammation stimulation and grievous toxicity. An ocean of charge shielding strategies is exploited, but the currently available siRNA delivery systems still remain ungratified and deficient. Herein, we developed a facile modular assembly strategy for a pH-sensitive charge reversal siRNA delivery system (PC), which can be easily obtained by adjusting the ratios of positively and negatively charged modules...
October 10, 2018: Biomaterials Science
Chengqiong Mao, Ping Qu, Michael J Miley, Yan Zhao, Zibo Li, Xin Ming
P-glycoprotein (Pgp) has been considered as a major cause of cancer multidrug resistance; however, clinical solutions to overcome this drug resistance do not exist despite the tremendous endeavors. The lack of cancer specificity is a main reason for clinical failure of conventional approaches. Targeted photodynamic therapy (PDT) is highly cancer specific by combining antibody targeting and locoregional light irradiation. We aimed to develop Pgp-targeted PDT using antibody-photosensitizer conjugates made of a recombinant Fab fragment...
October 9, 2018: Biomaterials Science
Zhaopei Guo, Lin Lin, Jie Chen, Xingzhi Zhou, Hon Fai Chan, Xuesi Chen, Huayu Tian, Meiwan Chen
To improve gene transfection efficiency in vitro and in vivo, we first grafted polyglycine (PGly) onto branched polyethyleneimine (PEI) (molecular weight MW 25 kDa) to obtain a novel gene vector PGly-PEI (PPG), before complexing it with poly(ethylene glycol)-poly-l-glutamate (PEG-PLG) for adjusting the charge density of PEI. We named the resulting nano-polyplex PG/PPG. The PPGs demonstrated improved gene transfection efficiency after grafting with polyglycine, and the efficiency could be further increased with the introduction of PEG-PLG...
October 5, 2018: Biomaterials Science
Zixian Bao, Yue Sun, Kamal Rai, Xinying Peng, Shilu Wang, Rui Nian, Mo Xian
Collagen has been widely documented as one of the most promising and competitive biomaterials for tissue engineering and medical applications. However, the properties of collagen differ from one source to another. In the present study, type I collagen (COL-I) was extracted and purified from the skins of Japanese sea bass (Lateolabrax japonicus) and Nile tilapia (Oreochromis niloticus). Ultraviolet (UV) spectroscopy, Fourier transform infrared spectroscopy (FTIR) and SDS-PAGE were performed to characterize both COL-Is...
October 4, 2018: Biomaterials Science
Wanjun Hu, Zhigang Zhang, Shenglin Lu, Tianzhu Zhang, Naizhen Zhou, Pengfei Ren, Faming Wang, Yang Yang, Zhenling Ji
Abdominal adhesion to polypropylene (PP) mesh remains one of the major complications in hernia repair. Thus, a challenge exists to endow PP mesh with powerful anti-adhesion properties in hernia repair. To investigate potential options, the assembled PP mesh was developed with effective anti-adhesion properties through an in situ coating of the mesh surface with self-fixable and biodegradable mussel-inspired hydrogels. Through mixing oxidized-carboxymethylcellulose functionalized with dopamine (OCMC-DA) with carboxymethylchitosan (CMCS), a layer of hydrogel (OCMC-DA/CMCS) can be formed in situ on the PP mesh without the addition of crosslinking agents; the dopamine then acts as an immobilization group to fix these hydrogels to the PP mesh and the tissue surface...
October 3, 2018: Biomaterials Science
Wai Hon Chooi, William Ong, Aoife Murray, Junquan Lin, Dean Nizetic, Sing Yian Chew
The use of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) is an attractive therapeutic option for damaged nerve tissues. To direct neuronal differentiation of stem cells, we have previously developed an electrospun polycaprolactone nanofiber scaffold that was functionalized with siRNA targeting Re-1 silencing transcription factor (REST), by mussel-inspired bioadhesive coating. However, the efficacy of nanofiber-mediated RNA interference on hiPSC-NPCs differentiation remains unknown...
October 2, 2018: Biomaterials Science
Ya-Nan Fan, Min Li, Ying-Li Luo, Qian Chen, Li Wang, Hou-Bing Zhang, Song Shen, Zhen Gu, Jun Wang
Message RNA-based vaccines with prominent advantages such as facile production, no requirement for nuclear entry and high safety without the need for integration into host genome have been shown to be potent activators of the cytotoxic immune system. However, wider applications of mRNA-based therapeutics have been hindered because of their intrinsically high vulnerability to expressed nucleases and difficulty while entering antigen-presenting cells (APCs) directly. Here, we investigated the potential of cationic lipid-assisted nanoparticles (CLAN), which form a clinically translatable nucleic acid delivery system working as a carrier of an mRNA vaccine...
September 28, 2018: Biomaterials Science
Chao Qi, Luming Xu, Yan Deng, Guobin Wang, Zheng Wang, Lin Wang
Full-thickness skin injury affects millions of people worldwide each year. It often leads to scar formation and loss of skin appendages even after clinical treatment. The majority of wound dressings currently used cannot achieve scarless skin regeneration with complete recovery of appendages such as hair follicles and sebaceous glands. Functional regeneration of these skin appendages is a great challenge. However, we achieved this goal by the successful development and utilization of a photo-crosslinkable sericin hydrogel (SMH) as a new type of wound dressing for repairing full-thickness skin injury...
September 27, 2018: Biomaterials Science
Jieming Li, Yan Liu, Huilan Li, Wei Shi, Xinzhou Bi, Qianqian Qiu, Bo Zhang, Wenlong Huang, Hai Qian
Subcellular organelle-specific reagents for simultaneous tumor targeting, imaging, and treatment are of enormous interest in cancer therapy. Herein, we present a mitochondria targeting micelle (PEG-AIE-TPP) by conjugating a triphenylphosphonium (TPP) with a fluorogen which can undergo aggregation-induced emission (AIE). At first, the in vitro and in vivo properties of the PEG-AIE-TPP micelle were characterized in detail. It was found that the micelle was reasonably stable at physiological pH and highly sensitive to mildly acidic pH stimuli...
September 27, 2018: Biomaterials Science
M C Serrano, M J Feito, A González-Mayorga, R Diez-Orejas, M C Matesanz, M T Portolés
Graphene-based materials are revealing a great promise for biomedical applications and demonstrating attractiveness for neural repair. In the context of neural tissue damage, the dialogue between neural and immune cells appears critical for driving regeneration, thus making the understanding of their relations pivotal. Herein, the acute response of RAW-264.7 macrophages on nanostructured reduced graphene oxide (rGO) microfibers has been evaluated through the analysis of cell parameters including proliferation, viability, intracellular content of reactive oxygen species, cell cycle, apoptosis, and cell size and complexity...
September 26, 2018: Biomaterials Science
Kai Huang, Yifan Zhang, Jing Lin, Peng Huang
Photoacoustic imaging (PAI) is a rapidly developing imaging technique for both fundamental research and clinical applications. Recent studies revealed that PAI in the second near-infrared (NIR-II) region exhibits enhanced deep-tissue imaging capability, which benefits from reduced photon scattering, minimized background noise and increased applicable power in comparison to PAI in the first near-infrared (NIR-I) region. This review focuses on the latest achievements on PAI in the NIR-II region. The advantages of shifting PAI from NIR-I to NIR-II is first compared, followed by discussions on nanomaterials as contrast agents for NIR-II PAI...
September 26, 2018: Biomaterials Science
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