journal
MENU ▼
Read by QxMD icon Read
search

Biomaterials Science

journal
https://www.readbyqxmd.com/read/28429809/successful-pegylation-of-hollow-encapsulin-nanoparticles-from-rhodococcus-erythropolis-n771-without-affecting-their-disassembly-and-reassembly-properties
#1
Seiichi Sonotaki, Taku Takami, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Yoshihiko Murakami
We developed a hollow PEGylated encapsulin nanoparticle from Rhodococcus erythropolis N771. The hollow engineered encapsulin nanoparticles with His-Tag and Lys residues on the surface were constructed by means of genetic recombination. The Lys residues on the particle surface were successfully PEGylated with a PEG derivative, methoxy-PEG-SCM. Consequently, we demonstrated that the hollow PEGylated engineered encapsulin nanoparticle could successfully disassemble or reassemble even after PEGylation in the presence or absence of a protein denaturing agent...
April 21, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28425537/using-fluorescently-labeled-magnetic-nanocomposites-as-a-dual-contrast-agent-for-optical-and-magnetic-resonance-imaging
#2
Taofeng Zhu, Xiuqin Ma, Ruhua Chen, Zhijun Ge, Jun Xu, Xiaoke Shen, Lei Jia, Tao Zhou, Yifeng Luo, Tieliang Ma
Dual-modality imaging probes synergistically combine magnetic resonance (MR) and fluorescence into a single nanocomposite. This promising technique affords a new level of flexibility for molecular imaging uses in biomedical research. In this study, we report a new strategy for the synthesis of a novel attapulgite nanorod-based atta@Fe3O4@[Ru(bpy)2(fmp)]Cl2 nanocomposite (atta@Fe3O4@Ru NC). Our synthesized NC has both photoluminescent and magnetic properties, bright fluorescence, as well as significant magnetic resonance...
April 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28422200/enhancing-mri-of-liver-metastases-with-a-zwitterionized-biodegradable-dendritic-contrast-agent
#3
Xiaoxuan Zhou, Mingzhou Ye, Yuxin Han, Jianbin Tang, Yue Qian, Hongjie Hu, Youqing Shen
Metastasis is the main reason for cancer-associated mortality, and accurate diagnostic imaging of metastases is critical for the clinical administration and tailoring personalized treatments for metastatic tumors. However, magnetic resonance imaging of metastases in the liver is impeded by its low sensitivity because the currently used contrast agents accumulate in hepatocytes and Kupffer cells instead of cancer cells. Herein, a 4(th) generation zwitterionized biodegradable dendritic contrast agent (DCA) with a size of ca...
April 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28406499/phospholipid-mimic-oxaliplatin-prodrug-liposome-for-treatment-of-the-metastatic-triple-negative-breast-cancer
#4
Bing Feng, Fangyuan Zhou, Wenchao Lu, Dangge Wang, Tingting Wang, Cheng Luo, Hao Wang, Yaping Li, Haijun Yu
A phospholipid-mimic oxaliplatin prodrug (Oxalipid) was synthesized, which could self-assemble into a liposomal nanostructure with a drug loading ratio as high as 27 wt%. Compared to free oxaliplatin, the resulting Oxalipid liposome displayed elongated blood circulation, increased tumor accumulation and improved anticancer efficacy against the metastatic triple negative breast cancer (TNBC).
April 13, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28406497/correction-rapid-fabrication-of-functionalised-poly-dimethylsiloxane-microwells-for-cell-aggregate-formation
#5
A Forget, A L S Burzava, B Delalat, K Vasilev, F J Harding, A Blencowe, N H Voelcker
Correction for 'Rapid fabrication of functionalised poly(dimethylsiloxane) microwells for cell aggregate formation' by A. Forget et al., Biomater. Sci., 2017, 5, 828-836.
April 13, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28401206/recent-advances-in-carbon-based-nanosystems-for-cancer-theranostics
#6
REVIEW
Shine Augustine, Jay Singh, Manish Srivastava, Monica Sharma, Asmita Das, Bansi D Malhotra
One of the major challenges in our contemporary society is to facilitate healthy life for all human beings. In this context, cancer has become one of the most deadly diseases around the world, and despite many advances in theranostics techniques the treatment of cancer still remains an important problem. With recent advances made in the field of nano-biotechnology, carbon-based nanostructured materials have drawn special attention because of their unique physicochemical properties, giving rise to great potential for the diagnosis and therapy of cancer...
April 12, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28378868/surface-coupling-strength-of-gold-nanoparticles-affects-cytotoxicity-towards-neurons
#7
A Q Tran, C Kaulen, U Simon, A Offenhäusser, D Mayer
Gold nanoparticles (AuNPs) are versatile nanomaterials which are frequently used to manipulate and study cellular behavior on the nanometer scale. However, it has been recognized that freely diffusing colloidal particles can possess severe cytotoxicity. One strategy to overcome this harmful side effect is to tether the nanoparticles to sample surfaces. In this study, the cytotoxicity of immobilized AuNPs is investigated as a function of their sizes, surface density, and binding strength. The AuNPs are modified with positively charged aminoalkyl thiol molecules to promote the cell adhesion, while their background is passivated...
April 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28378865/mustard-inspired-delivery-shuttle-for-enhanced-blood-brain-barrier-penetration-and-effective-drug-delivery-in-glioma-therapy
#8
Nan Wang, Pei Sun, Mingming Lv, Gangsheng Tong, Xin Jin, Xinyuan Zhu
Effective penetration through the blood-brain barrier (BBB) remains a challenge for the treatment of many brain diseases. In this study, a small molecule, sinapic acid (SA), extracted from mustard, was selected as a novel bioinspired BBB-permeable ligand for efficient drug delivery in glioma treatment. SA was conjugated on the surface of zwitterionic polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-encapsulated bovine serum albumin (BSA)-based nanoparticles, yielding nBSA-SA. The PMPC shell serves as a protective layer to prolong the in vivo blood circulation time with a better chance to cross the BBB...
April 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28358402/mesoporous-iron-carboxylate-metal-organic-frameworks-synthesized-by-the-double-template-method-as-a-nanocarrier-platform-for-intratumoral-drug-delivery
#9
Zhengfei Wu, Na Hao, Hai Zhang, Zhaoyuan Guo, Rong Liu, Bin He, Sai Li
Metal-organic frameworks as a powerful platform for drug delivery have attracted significant attention in recent years. In this study, mesoporous iron-metal-organic framework nanoparticles (mesoMOFs) were synthesized via the double-template method. Cetyltrimethylammonium bromide (CTAB) and citric acid (CA) were chosen as the double-template agent. The mesoMOFs were characterized by EDX, elemental analysis, TG, BET, SEM, TEM, and DLS. The anticancer drug doxorubicin hydrochloride (DOX) was encapsulated in the mesoMOFs, and the DOX loading content was up to 55 wt%...
March 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28352857/facile-construction-of-mitochondria-targeting-nanoparticles-for-enhanced-phototherapeutic-effects
#10
Yi Liu, Heping Li, Jin Xie, Mengxue Zhou, Hui Huang, Huiru Lu, Zhifang Chai, Jun Chen, Yi Hu
Phototherapy, as a noninvasive therapeutic procedure, has been applied to treat tumors. However, the application of phototherapy is often compromised by its low efficiency. Herein, we developed a novel nanoplatform based on cationic amphiphilic polymer-wrapped carbon nanotubes (rPAA@SWCNTs) with a photosensitizer, indocyanine green (ICG), for phototherapy. The as-prepared nanoparticles exhibited excellent mitochondria targeting due to the synergistic properties of highly positive charges from the polycations on the corona and the high hydrophobicity from the carbon nanotubes in the core...
March 29, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28338134/uniform-tio2-nanoparticles-induce-apoptosis-in-epithelial-cell-lines-in-a-size-dependent-manner
#11
Qingqing Sun, Takayuki Ishii, Koki Kanehira, Takeshi Sato, Akiyoshi Taniguchi
The size of titanium dioxide (TiO2) nanoparticles is a vital parameter that determines their cytotoxicity. However, most reported studies have employed irregular shapes and sizes of TiO2 nanoparticles, as it is difficult to produce nanoparticles of suitable sizes for research. We produced good model TiO2 nanoparticles of uniform shape and size for use in studying their cytotoxicity. In this work, spherical, uniform polyethylene glycol-modified TiO2 (TiO2-PEG) nanoparticles of differing sizes (100, 200, and 300 nm) were prepared using the sol-gel method...
March 24, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28333169/outstanding-reviewers-for-biomaterials-science-in-2016
#12
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 23, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28327716/chemo-photodynamic-combined-gene-therapy-and-dual-modal-cancer-imaging-achieved-by-ph-responsive-alginate-chitosan-multilayer-modified-magnetic-mesoporous-silica-nanocomposites
#13
Hong Yang, Yin Chen, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Xue Shen, Tingting Li, Shun Li, Chunhui Wu, Yiyao Liu
Multifunctional theranostics have offered some interesting new opportunities for cancer therapy and diagnosis in the last decade. Herein, magnetic mesoporous silica nanoparticles (M-MSNs) were designed and synthesized, then the photosensitizer chlorin e6 (Ce6) and antitumor drug doxorubicin (Dox) were adsorbed onto the M-MSNs. Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance...
March 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28304023/peptide-functionalized-gold-nanoparticles-versatile-biomaterials-for-diagnostic-and-therapeutic-applications
#14
REVIEW
Jingyi Zong, Steven L Cobb, Neil R Cameron
Colloidal gold solutions have been used for centuries in a wide variety of applications including staining glass and in the colouring of ceramics. More recently, gold nanoparticles (GNPs) have been studied extensively due to their interesting size-dependent electronic and optical properties. GNPs can be functionalized easily with biomolecules that contain thiols, amines, or even phosphine moieties. For example, the reaction of thiol-containing peptides with GNPs has been used extensively to prepare novel hybrid materials for biomedical applications...
March 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28300268/rgo-aunr-ha-5fu-nanocomposite-with-multi-stage-release-behavior-and-efficient-antitumor-activity-for-synergistic-therapy
#15
Ying Yang, Yunlong Wang, Manzhou Zhu, Yan Chen, Yazhong Xiao, Yuhua Shen, Anjian Xie
A reduced graphene oxide (RGO)/gold nanorod (AuNR)/hydroxyapatite (HA) nanocomposite was designed and successfully synthesized for the first time. An anticancer drug, 5-fluorouracil (5FU), was chosen as a model drug to be loaded in RGO/AuNR/HA. The fabricated RGO/AuNR/HA-5FU showed robust, selective targeting and penetrating efficiency against HeLa cells due to the good compatibility and nontoxicity of HA, and showed excellent synergetic antitumor effects through combined chemotherapy (CT) by 5FU and photothermal therapy (PTT) by both RGO and AuNRs under near-infrared (NIR) laser irradiation...
March 16, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28294240/pegylation-corannulene-enhances-response-of-stress-through-promoting-neurogenesis
#16
Xinyu Li, Dandan Sun, Xu Li, Dashuai Zhu, Zhenzhen Jia, Jiajia Jiao, Kai Wang, Deling Kong, Xin Zhao, Lin Xu, Qiang Zhao, Dongyan Chen, Xizeng Feng
Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene...
March 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28294225/enhanced-sealing-strength-of-a-hydrophobically-modified-alaska-pollock-gelatin-based-sealant
#17
Y Mizuno, R Mizuta, M Hashizume, T Taguchi
The aim of this study was the development of an innovative biocompatible sealant composed of Alaska pollock-derived gelatin partially modified with a dodecyl group (C12-ApGltn) and a poly(ethylene glycol)-based crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate. The burst strength of the developed sealants was measured using porcine aorta and rat lungs. The maximum burst strength of a C12-ApGltn-based sealant against the porcine aorta was 4-fold higher than that of an original ApGltn (Org-ApGltn)-based sealant...
March 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28287223/bioresorbable-polypeptide-based-comb-polymers-efficiently-improves-the-stability-and-pharmacokinetics-of-proteins-in-vivo
#18
Md Hasan Turabee, Thavasyappan Thambi, Jae Seung Lym, Doo Sung Lee
Stimuli-responsive polypeptides are a promising class of biomaterials due to their tunable physicochemical and biological properties. Herein, a series of novel pH- and thermo-responsive block copolymers based on polypeptides were synthesized by ring-opening polymerization of γ-benzyl-l-glutamate-N-carboxyanhydride in the presence of poly(ethylene glycol)-diamine macroinitiator followed by aminolysis. The resulting polypeptide-based triblock copolymer, poly[(2-(dibutylamino)ethyl-l-glutamate)-co-(γ-benzyl-l-glutamate)]-poly(ethylene glycol)-b-poly[(2-(dibutylamino)ethyl-l-glutamate)-co-(γ-benzyl-l-glutamate)] (PNLG-co-PBLG-b-PEG-b-PBLG-co-PNLG), exists as a low viscous sol at low pH and temperature (≤pH 6...
March 13, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28282092/nir-emitting-and-photo-thermal-active-nanogold-as-mitochondria-specific-probes
#19
Sabyasachi Chakrabortty, Miguel Sison, Yuzhou Wu, Anita Ladenburger, Goutam Pramanik, Johannes Biskupek, Jerome Extermann, Ute Kaiser, Theo Lasser, Tanja Weil
We report a bioinspired multifunctional albumin derived polypeptide coating comprising grafted poly(ethylene oxide) chains, multiple copies of the HIV TAT derived peptide enabling cellular uptake as well as mitochondria targeting triphenyl-phosphonium (TPP) groups. Exploring these polypeptide copolymers for passivating gold nanoparticles (Au NPs) yielded (i) NIR-emitting markers in confocal microscopy and (ii) photo-thermal active probes in optical coherence microscopy. We demonstrate the great potential of such multifunctional protein-derived biopolymer coatings for efficiently directing Au NP into cells and to subcellular targets to ultimately probe important cellular processes such as mitochondria dynamics and vitality inside living cells...
March 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28280817/yolk-structured-multifunctional-up-conversion-nanoparticles-for-synergistic-photodynamic-sonodynamic-antibacterial-resistance-therapy
#20
Feiya Xu, Min Hu, Chengcheng Liu, Seok Ki Choi
The worldwide increase in bacterial antibiotic resistance has led to a search for alternative antibacterial therapies. The present study reports the development of yolk-structured multifunctional up-conversion nanoparticles (UCNPs) that combine photodynamic and sonodynamic therapy for effective killing of antibiotic-resistant bacteria. The multifunctional nanoparticles (NPs) were achieved by enclosing hematoporphyrin monomethyl ether (HMME) into its yolk-structured up-conversion core and covalently linked rose bengal (RB) on its silica (SiO2) shell...
March 10, 2017: Biomaterials Science
journal
journal
47527
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"