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Biomaterials Science

Pingyun Yuan, Xinyu Qiu, Ronghua Jin, Yongkang Bai, Shiyu Liu, Xin Chen
Herein, we reveal a double emulsion method combining the sol-gel method to prepare poly(lactic-co-glycolic acid) microspheres with different porous structures for sequential release of two types of biomolecules. By controlling the ripening time of the emulsion, multiple interconnected chambers could be easily chosen to be either embedded in microspheres or opened to the surface. These two types of microspheres exhibited different kinetics for the release of both small molecules and proteins, where the release from microspheres with open pores (5 day over 90%) was much faster than the release from microspheres with embedded pores (25 day over 90%)...
February 20, 2018: Biomaterials Science
Hau Van Duong, Trang The Lieu Chau, Nhan Thi Thanh Dang, Duc Van Nguyen, Son Lam Le, Thang Sy Ho, Tuyen Phi Vu, Thi Thi Van Tran, Thanh-Dinh Nguyen
Inspired by nature, collagen is an outstanding polypeptide utilized to exploit its bioactivity and material design for healthcare technologies. In this study, we describe the self-aggregation of water-dispersible nanocollagen helices upon solidification to fabricate different forms of natural collagen materials. Chemically extracted native collagen fibrils are uniform anisotropic nanoparticles with an average diameter of about 50 nm and a high aspect ratio. The as-prepared collagen nanofibrils are soluble in sodium acetate-acetic acid buffer and are dispersible in water, thus generating collagen liquids that are used as distinct biopolymer precursors for materials development...
February 20, 2018: Biomaterials Science
S Hamidreza Arabi, Behdad Aghelnejad, Christian Schwieger, Annette Meister, Andreas Kerth, Dariush Hinderberger
We report extended pH- and temperature-induced preparation procedures and explore the materials and molecular properties of different types of hydrogels made from human and bovine serum albumin, the major transport protein in the blood of mammals. We describe the diverse range of properties of these hydrogels at three levels: (1) their viscoelastic (macroscopic) behavior, (2) protein secondary structure changes during the gelation process (via ATR-FTIR spectroscopy), and (3) the hydrogel fatty acid (FA) binding capacity and derive from this the generalized tertiary structure through CW EPR spectroscopy...
February 15, 2018: Biomaterials Science
Abdel Rahman Abdel Fattah, Sarah Mishriki, Tobias Kammann, Rakesh P Sahu, Fei Geng, Ishwar K Puri
A magnet array is employed to manipulate diamagnetic cells that are contained in paramagnetic medium to demonstrate for the first time the contactless bioprinting of three-dimensional (3D) cellular structures and co-cultures of breast cancer MCF-7 and endothelial HUVEC at prescribed locations on tissue culture treated well plates. Sequential seeding of different cell lines and the spatial displacement of the magnet array creates co-cultured cellular structures within a well without using physically intrusive well inserts...
February 15, 2018: Biomaterials Science
F Q Cao, M M Yan, Y J Liu, L X Liu, L Lu, H Wang, Ch Zhang, H F Sun, D L Kong, G L Ma
Herein, the photosensitizer indocyanine green (ICG) is used to induce the self-assembly of antigens to form nanovaccines. Under near-infrared (NIR) laser irradiation, reactive oxygen species can be generated by nanovaccines to disrupt the membranes of endo/lysosomes, which helps to release antigens into the cytosol efficiently, thereby enhancing antigen cross-presentation and anti-cancer immunity. To the best of our knowledge, this study represents the first example of ICG as a biocompatible adjuvant to improve cancer vaccine efficacy...
February 13, 2018: Biomaterials Science
Chen Li, Rongrong Qin, Ruirui Liu, Shuting Miao, Peng Yang
With the development of nanotechnology, functional amyloid materials are drawing increasing attention, and numerous remarkable applications are emerging. Amyloids, defined as a class of supramolecular assemblies of misfolded proteins or peptides into β-sheet fibrils, have evolved in many new respects and offer abundant chemical/biological functions. These proteinaceous micro/nano-structures provide excellent biocompatibility, rich phase behaviours, strong mechanical properties, and stability at interfaces not only in nature but also in functional materials, displaying versatile interactions with surfaces/interfaces that have been widely adopted in bioadhesion, synthetic biology, and composites...
February 13, 2018: Biomaterials Science
Xiaoyue Han, Xinyu Song, Bowei Li, Fabiao Yu, Lingxin Chen
Sulfane sulfur refers to ionized sulfur that is reversibly attached to other sulfur atoms in the form of 6-valence electrons (S0). Sulfane sulfur possesses stronger nucleophilicity and reducibility than hydrogen sulfide in a series of physiological reactions, which probably makes sulfane sulfur the actual signal molecule in cells. Herein, we designed and synthesized a near-infrared (NIR) fluorescent probe BD-diSH for sensitive detection and imaging of sulfane sulfur in living cells and in vivo. The probe BD-diSH is composed of two moieties: the fluorophore azo-BODIPY and the sulfane sulfur recognition unit, viz...
February 12, 2018: Biomaterials Science
Md Hasan Turabee, Thavasyappan Thambi, Huu Thuy Trang Duong, Ji Hoon Jeong, Doo Sung Lee
Sustained delivery of protein therapeutics is limited owing to the fragile nature of proteins. Despite its great potential, delivery of proteins without any loss of bioactivity remains a challenge in the use of protein therapeutics in the clinic. To surmount this shortcoming, we report a pH- and temperature-responsive in situ-forming injectable hydrogel based on comb-type polypeptide block copolymers for the controlled delivery of proteins. Polypeptide block copolymers, composed of hydrophilic polyethylene glycol (PEG), temperature-responsive poly(γ-benzyl-l-glutamate) (PBLG), and pH-responsive oligo(sulfamethazine) (OSM), exhibit pH- and temperature-induced sol-to-gel transition behavior in aqueous solutions...
February 9, 2018: Biomaterials Science
Sheng-Jen Cheng, Hsien-Yi Chiu, Priyank V Kumar, Kuan Yu Hsieh, Jia-Wei Yang, You-Rong Lin, Yu-Chih Shen, Guan-Yu Chen
Graphene oxide (GO), a derivative of graphene, and its related nanomaterials have attracted much attention in recent years due to the excellent biocompatibility and large surface area of GO with abundant oxygen functional groups, which further enable it to serve as a nano-bio interface. Herein, we demonstrate the induction of blue fluorescence in GO suspensions via a mild thermal annealing procedure. Additionally, this procedure preserves the oxygen functional groups on the graphene plane which enables the conjugation of cancer drugs without obvious cytotoxicity...
February 8, 2018: Biomaterials Science
Xiao-Jiao Du, Ji-Long Wang, Shoaib Iqbal, Hong-Jun Li, Zhi-Ting Cao, Yu-Cai Wang, Jin-Zhi Du, Jun Wang
Surface charge plays an important role in determining the interactions of nanoparticles with biological components. Substantial studies have demonstrated that surface charge affects the fate of nanoparticles after intravenous administration; however, few studies have investigated the effect of surface charge on the bioavailability and absorption of nanoparticles after oral administration. In this study, polymeric nanoparticles with a similar particle size and surface polyethylene glycol (PEG) density, but with varying surface charges (positive, negative and neutral), were developed to study the effect of surface charge on the oral absorption of polymeric nanoparticles...
February 7, 2018: Biomaterials Science
Pingzhang Chen, Yunhong Liu, Jing Zhao, Xiaojuan Pang, Peifa Zhang, Xiaohu Hou, Ping Chen, Cheng-Yi He, Zhiyong Wang, Zhi-Ying Chen
Bispecific T-cell engagers (BiTEs) are single chain variable fragments with specific structures, which could connect the surface antigen on cancer cells and CD3 ligands on T cells, and then engage the T cells for cancer immunotherapy. In this report, a novel organic-inorganic hybrid gene delivery system composed of stearic acid modified polyethyleneimine (stPEI) and calcium phosphate (CaP) was used to deliver MC.DNA into cells to express BiTE antibodies. This gene delivery system exhibits high transfection efficiency, long-term effects and low cytotoxicity in vitro...
February 7, 2018: Biomaterials Science
Xifeng Liu, Ping Gong, Pengfei Song, Feng Xie, A Lee Miller Ii, Shigao Chen, Lichun Lu
Functionalization of microbubbles (MBs) is a difficult issue due to their unstable nature. Here we report a fast and versatile method using a strain promoted alkyne-azide cycloaddition (SPAAC) click reaction for microbubble functionalization. An azadibenzocyclooctyne (DBCO) group was first introduced onto the MB surface and then an azide group into the desired ligand. Without any initiators or catalysts, essential click ligation occurred within 1 min and a majority of the reaction completed in 5 min at 37 °C...
February 7, 2018: Biomaterials Science
Fu-Hua Liu, Chun-Yuan Hou, Di Zhang, Wen-Jing Zhao, Yong Cong, Zhong-Yu Duan, Zeng-Ying Qiao, Hao Wang
Peptide nanodrugs have been developed as promising antitumor chemotherapeutics because they partially overcome the drawbacks of free peptide drugs, but insufficient tumor penetration and interference of peptide function limit their further application. In this work, we have developed multifunctional peptide conjugated dendrimers for improving tumor penetration, cancer cell-specific peptide delivery and anticancer ability. The cytotoxic peptide KLAK, cell-penetrating peptide TAT and matrix metalloproteinase 2 (MMP2)-sensitive peptide-poly(ethylene glycol) (PEG) were conjugated onto dendrimers by one-pot synthesis to gain PKT-S-PEG...
February 6, 2018: Biomaterials Science
Tengyi Zheng, Xintian Huang, Jintian Chen, Disang Feng, Liling Mei, Ying Huang, Guilan Quan, Chune Zhu, Vikramjeet Singh, Hao Ran, Xin Pan, Chuan-Yu Wu, Chuanbin Wu
Lyotropic liquid crystals (LLC) have received increasing attention as a drug delivery system. In this study, a novel intra-canal disinfectant based on the glycerol monooleate (GMO) LLC precursor incorporation with chlorhexidine (CHX) and silver nanoparticles (Ag-NPs) was designed and evaluated. The LLC precursor with excellent fluidity was able to penetrate deeply into the complex tiny collateral branch root canals. The transformation of cubic LLC in root canals upon coming into contact with water provided long-lasting disinfection against multidrug-resistant bacteria to avoid the endodontic reinfection and follow-up visits...
February 6, 2018: Biomaterials Science
Abbygail A Foster, Ruby E Dewi, Lei Cai, Luqia Hou, Zachary Strassberg, Cynthia A Alcazar, Sarah C Heilshorn, Ngan F Huang
A key feature of peripheral arterial disease (PAD) is damage to endothelial cells (ECs), resulting in lower limb pain and restricted blood flow. Recent preclinical studies demonstrate that the transplantation of ECs via direct injection into the affected limb can result in significantly improved blood circulation. Unfortunately, the clinical application of this therapy has been limited by low cell viability and poor cell function. To address these limitations we have developed an injectable, recombinant hydrogel, termed SHIELD (Shear-thinning Hydrogel for Injectable Encapsulation and Long-term Delivery) for cell transplantation...
February 6, 2018: Biomaterials Science
Junqing Wang, Heng Liu, Yu Liu, Chengchao Chu, Youyuan Yang, Yun Zeng, Weiguo Zhang, Gang Liu
In this work, we report on biodegradable eumelanin-Fe3O4 hybrid nanoparticles (euMel-Fe3O4 NPs) for multiple imaging-assisted local photothermolysis. The euMel-Fe3O4 NPs are rationally prepared via a facile one-step co-precipitation method in the aqueous phase in the presence of eumelanin. The obtained NPs exhibited high stability and aqueous dispersity. euMel-Fe3O4 NPs could provide T2-weighted magnetic resonance (MR) and photoacoustic (PA) imaging contrast enhancement prior to the treatment, due to their high r2 relaxivity that was determined to be 245...
February 1, 2018: Biomaterials Science
H Enis Enis Karahan, Yilei Wang, Wei Li, Fei Liu, Liang Wang, Xiao Sui, Muhammad Adil Riaz, Yuan Chen
Graphene materials (GMs) exhibit attractive antimicrobial activities promising for biomedical and environmental applications. However, we still lack full control over their behaviour and performance mainly due to the complications arising from the coexistence and interplay of multiple factors. Therefore, in this minireview, we attempt to illustrate the structure-property-activity relationships of GMs' antimicrobial activity. We first examine the chemical/physical complexity of GMs focusing on five aspects of their materials characteristics: (i) chemical composition, (ii) impurities and imperfections, (iii) lateral dimension, (iv) self-association (e...
February 1, 2018: Biomaterials Science
Wei Long Ng, Min Hao Goh, Wai Yee Yeong, May Win Naing
Native tissues and/or organs possess complex hierarchical porous structures that confer highly-specific cellular functions. Despite advances in fabrication processes, it is still very challenging to emulate the hierarchical porous collagen architecture found in most native tissues. Hence, the ability to recreate such hierarchical porous structures would result in biomimetic tissue-engineered constructs. Here, a single-step drop-on-demand (DOD) bioprinting strategy is proposed to fabricate hierarchical porous collagen-based hydrogels...
January 31, 2018: Biomaterials Science
Yingbo Wang, Ling Yan, Ruoyu Cheng, Mirigul Muhtar, Xinxin Shan, Yi Xiang, Wenguo Cui
The incorporation of hydroxyapatite nanoparticles onto the surface of titanium is an effective method to improve its osteoinductive ability. However, there are still issues with the hydroxyapatite nanoparticle coatings fabricated using current methods, such as particle aggregation and unsatisfactory binding ability with the matrix, in addition to the difficulties in the multi-functionalization of antibacterial, anti-wear and bioinductive ability. In the present study, we propose a strategy to fabricate a refined hydroxyapatite nanoparticles/copper nanoparticles co-deposition titanium matrix by the mediation of pulse electrochemical polymerized pyrrole through its coordination and doping of cations and anions...
January 31, 2018: Biomaterials Science
Mark Gontsarik, Mahsa Mohammadtaheri, Anan Yaghmur, Stefan Salentinig
The delivery of poorly water-soluble antimicrobial peptides (AMPs) that are sensitive to degradation is a major challenge in the pharmaceutical field. In this study, we design and characterize a pH-sensitive nanocarrier with the potential for delivery of AMPs and their protection from degradation. These nanobiointerfaces are prepared through the self-assembly of oleic acid (OA) with the human cathelicidin LL-37 in excess water. Advanced experimental methods including synchrotron small angle X-ray scattering, cryogenic transmission electron microscopy, and dynamic light scattering were used to characterize the OA/LL-37 self-assemblies and their structural alterations in response to changes in pH and composition...
January 31, 2018: Biomaterials Science
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