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Biomaterials Science

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https://www.readbyqxmd.com/read/29214247/isomeric-control-of-the-mechanical-properties-of-supramolecular-filament-hydrogels
#1
Yi-An Lin, Myungshim Kang, Wei-Chiang Chen, Yu-Chuan Ou, Andrew G Cheetham, Pei-Hsun Wu, Denis Wirtz, Sharon M Loverde, Honggang Cui
Supramolecular filament hydrogels are an emerging class of biomaterials that hold great promise for regenerative medicine, tissue engineering, and drug delivery. However, fine-tuning of their bulk mechanical properties at the molecular level without altering their network structures remains a significant challenge. Here we report an isomeric strategy to construct amphiphilic peptides through the conjugation of isomeric hydrocarbons to influence the local viscoelastic properties of their resulting supramolecular hydrogels...
December 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29210373/enhanced-cell-adhesion-on-a-bio-inspired-hierarchically-structured-polyester-modified-with-gelatin-methacrylate
#2
Ping Li, Xiaoqiu Dou, Chuanliang Feng, Holger Schönherr
Herein, fabrication and modification of novel bio-inspired microwell arrays with nanoscale topographic structures are reported. The natural nano- and microstructures present on the surface of rose petals were hypothesized to enhance cell-surface contacts. Thus hierarchically structured polyethylene terephthalate glycol modified (PETG) substrates were fabricated by replication from rose petals via nanoimprint lithography, followed by covalent modification and crosslinking with RGD-presenting gelatin-methacrylate (GelMA) for promoting cell adhesion and spreading...
December 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29210372/melanin-manganese-nanoparticles-with-ultrahigh-efficient-clearance-in-vivo-for-tumor-targeting-t1-magnetic-resonance-imaging-contrast-agent
#3
Wen Xu, Jinghua Sun, Liping Li, Xiaoyang Peng, Ruiping Zhang, Binquan Wang
Endogenous biomaterials in organisms, with native biocompatibility and biodegradability, appear more advantageous in the development of nanoscale diagnostic and therapeutic systems for future clinical translation. Herein, a novel tumor-targeting Magnetic Resonance Imaging (MRI) contrast agent was developed based on Mn2+-chelating ultrasmall water-soluble melanin nanoparticles (MNP-PEG-Mn). The nanoparticles, with a size of about 5.6 nm, presented high chelation stability and showed negligible cytotoxicity as estimated by MTT assay...
December 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29199748/zwitterionic-stealth-peptide-protected-gold-nanoparticles-enable-long-circulation-without-the-accelerated-blood-clearance-phenomenon
#4
Jue Zhao, Zhihui Qin, Jina Wu, Lijie Li, Qiao Jin, Jian Ji
Poly(ethylene glycol) (PEG), which is considered as a gold standard for surface modification of nanoparticles in biomedical applications, has been reported to encounter the accelerated blood clearance (ABC) phenomenon after repeated administration. Herein, as an ideal substitute for PEG, a zwitterionic peptide sequence of alternating negatively charged glutamic acid (E) and positively charged lysine (K) was designed as a good candidate for surface modification of nanoparticles without the ABC phenomenon in vivo...
December 4, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29189838/an-engineered-cell-imprinted-substrate-directs-osteogenic-differentiation-in-stem-cells
#5
Khorshid Kamguyan, Ali Asghar Katbab, Morteza Mahmoudi, Esben Thormann, Saeed Zajforoushan Moghaddam, Lida Moradi, Shahin Bonakdar
A cell-imprinted poly(dimethylsiloxane)/hydroxyapatite nanocomposite substrate was fabricated to engage topographical, mechanical, and chemical signals to stimulate and boost stem cell osteogenic differentiation. The physicochemical properties of the fabricated substrates, with nanoscale resolution of osteoblast morphology, were probed using a wide range of techniques including scanning electron microscopy, atomic force microscopy, dynamic mechanical thermal analysis, and water contact angle measurements. The osteogenic differentiation capacity of the cultured stem cells on these substrates was probed by alizarin red staining, ALP activity, osteocalcin measurements, and gene expression analysis...
November 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29188240/spions-for-cell-labelling-and-tracking-using-mri-magnetite-or-maghemite
#6
Michael Barrow, Arthur Taylor, Ana M Fuentes-Caparrós, Jack Sharkey, Luke M Daniels, Pranab Mandal, B Kevin Park, Patricia Murray, Matthew J Rosseinsky, Dave J Adams
Although there is extensive literature covering the biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs), the phase of the iron oxide core used is not often taken into account when cell labelling and tracking studies for regenerative medicine are considered. Here, we use a co-precipitation reaction to synthesise particles of both magnetite- (Fe3O4) and maghemite- (γ-Fe2O3) based cores and consider whether the extra synthesis step to make maghemite based particles is advantageous for cell tracking...
November 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29186237/a-redox-responsive-mesoporous-silica-based-nanoplatform-for-in-vitro-tumor-specific-fluorescence-imaging-and-enhanced-photodynamic-therapy
#7
Fan Yuan, Jiang-Lan Li, Han Cheng, Xuan Zeng, Xian-Zheng Zhang
In order to obtain an optimal therapeutic effect with minimal systemic toxicity, a redox-responsive mesoporous silica nanoparticle (MSN)-based platform modified with protoporphyrin IX (PpIX)-multifunctional peptides was synthesized as an intelligent theranostic agent carrier. This redox-responsive nanoplatform could release the theranostic agent under a glutathione stimulus, produce fluorescence recovery for tumor-specific fluorescence imaging and provide tumor-enhanced photodynamic therapy.
November 29, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29184942/bone-targeting-poly-ethylene-sodium-phosphate
#8
Yasuhiko Iwasaki, Atsushi Yokota, Akihisa Otaka, Naoyuki Inoue, Akane Yamaguchi, Toru Yoshitomi, Keitaro Yoshimoto, Masashi Neo
Poly(ethylene sodium phosphate) (PEP·Na) showed excellent cytocompatibility and in vivo bone affinity. Moreover, PEP·Na did not interact with thrombin, which is a coagulation-related protein. Because immobilization of therapeutic agents and imaging probes on PEP·Na is easily performed, PEP·Na is a promising polymer for bone-targeted therapies.
November 29, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29184938/minocycline-hydrochloride-loaded-on-titanium-by-graphene-oxide-an-excellent-antibacterial-platform-with-the-synergistic-effect-of-contact-killing-and-release-killing
#9
Wenhao Qian, Jiajun Qiu, Jiansheng Su, Xuanyong Liu
Titanium and its alloys have been widely used in orthopedic and dental implants because of their excellent properties. However, implant failures still occur due to implant-associated bacterial infections. Therefore, proper surface modification of titanium and its alloys is necessary. In this work, commercial pure titanium plates were modified with graphene oxide (GO) which was used to load minocycline hydrochloride. Gram-positive Staphylococcus aureus (S. aureus) and Streptococcus mutans (S. mutans) and Gram-negative Escherichia coli (E...
November 29, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29184934/extracellular-vesicles-exosomes-and-shedding-vesicles-in-regenerative-medicine-a-new-paradigm-for-tissue-repair
#10
REVIEW
I M Bjørge, S Y Kim, J F Mano, B Kalionis, W Chrzanowski
Tissue regeneration by stem cells is driven by the paracrine activity of shedding vesicles and exosomes, which deliver specific cargoes to the recipient cells. Proteins, RNA, cytokines and subsequent gene expression, orchestrate the regeneration process by improving the microenvironment to promote cell survival, controlling inflammation, repairing injury and enhancing the healing process. The action of microRNA is widely accepted as an essential driver of the regenerative process through its impact on multiple downstream biological pathways, and its ability to regulate the host immune response...
November 29, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29181462/chemical-amplification-accelerates-reactive-oxygen-species-triggered-polymeric-degradation
#11
Sangeun Lee, Alexandra Stubelius, Jason Olejniczak, Hongje Jang, Viet Anh Nguyen Huu, Adah Almutairi
Chemical amplification is a known strategy for improving the sensitivity of stimuli-responsive polymers. However, the chemical amplification effect has never been fully examined. Many questions remain about its mechanism and efficacy, obstructing its further implementation. Here, we design and demonstrate a reactive oxygen species (ROS) responsive polymer (ROS-ARP) with a chemical amplification strategy to dismiss these concerns. The ROS-ARP is designed to change the hydrophilicity by ROS, revealing a carboxylic acid, which also catalyzes ketal hydrolysis along the polymer backbone...
November 28, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29177268/advanced-manufacturing-of-microdisk-vaccines-for-uniform-control-of-material-properties-and-immune-cell-function
#12
Qin Zeng, Peipei Zhang, Xiangbin Zeng, Lisa H Tostanoski, Christopher M Jewell
The continued challenges facing vaccines in infectious disease and cancer highlight a need for better control over the features of vaccines and the responses they generate. Biomaterials offer unique advantages to achieve this goal through features such as controlled release and co-delivery of antigens and adjuvants. However, many synthesis strategies lead to particles with heterogeneity in diameter, shape, loading level, or other properties. In contrast, advanced manufacturing techniques allow precision control of material properties at the micro- and nano-scale...
November 27, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29170782/coordination-driven-assembly-of-catechol-modified-chitosan-for-the-kidney-specific-delivery-of-salvianolic-acid-b-to-treat-renal-fibrosis
#13
Jing Li, Cuiting Zhang, Weiming He, Hongzhi Qiao, Jiahui Chen, KaiKai Wang, David Oupický, Minjie Sun
Kidney-specific delivery is critically important for the treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by the coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions and Sal B. The prepared HCA-Chi-Ca-Sal B (HChi-Ca-Sal B) nanocomplex reversed the TGF-β1-induced epithelial-mesenchymal transition (EMT) in HK-2 cells. In vivo imaging demonstrated a kidney-specific biodistribution of the nanocomplex...
November 24, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29167844/recellularization-of-decellularized-adipose-tissue-derived-stem-cells-role-of-the-cell-secreted-extracellular-matrix-in-cellular-differentiation
#14
V Guneta, Z Zhou, N S Tan, S Sugii, M T C Wong, C Choong
Adipose-derived stem cells (ASCs) are found in a location within the adipose tissue known as the stem cell niche. The ASCs in the niche are maintained in the quiescent state, and upon exposure to various microenvironmental triggers are prompted to undergo proliferation or differentiation. These microenvironmental triggers also modulate the extracellular matrix (ECM), which interacts with the cells through the cytoskeleton and induces downstream events inside the cells that bring about a change in cell behaviour...
November 23, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29164196/supramolecular-polymeric-biomaterials
#15
REVIEW
Joseph L Mann, Anthony C Yu, Gillie Agmon, Eric A Appel
Polymeric chains crosslinked through supramolecular interactions-directional and reversible non-covalent interactions-compose an emerging class of modular and tunable biomaterials. The choice of chemical moiety utilized in the crosslink affords different thermodynamic and kinetic parameters of association, which in turn illustrate the connectivity and dynamics of the system. These parameters, coupled with the choice of polymeric architecture, can then be engineered to control environmental responsiveness, viscoelasticity, and cargo diffusion profiles, yielding advanced biomaterials which demonstrate rapid shear-thinning, self-healing, and extended release...
November 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29164186/phenylalanine-and-derivatives-as-versatile-low-molecular-weight-gelators-design-structure-and-tailored-function
#16
REVIEW
Tanmay Das, Marleen Häring, Debasish Haldar, David Díaz Díaz
Phenylalanine (Phe) is an essential amino acid classified as neutral and nonpolar due to the hydrophobic nature of the benzyl side chain. In the field of materials science, the chemical modification of phenylalanine at C or N terminus has enabled to synthesize a large number of low-molecular-weight gelators over the past decade. Thus, many physical (or supramolecular) softgel materials have been fabricated by self-assembly of Phe-derived building blocks, which can be programmed with atomic level information and modification...
November 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29148548/acrylate-based-materials-for-heart-valve-scaffold-engineering
#17
Rosaria Santoro, Seshasailam Venkateswaran, Francesco Amadeo, Rong Zhang, Maura Brioschi, Anthony Callanan, Marco Agrifoglio, Cristina Banfi, Mark Bradley, Maurizio Pesce
Calcific aortic valve disease (CAVD) is the most frequent cardiac valve pathology. Its standard treatment consists of surgical replacement either with mechanical (metal made) or biological (animal tissue made) valve prostheses, both of which have glaring deficiencies. In the search for novel materials to manufacture artificial valve tissue, we have conducted a high-throughput screening with subsequent up-scaling to identify non-degradable polymer substrates that promote valve interstitial cells (VICs) adherence/growth and, at the same time, prevent their evolution toward a pro-calcific phenotype...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29147717/the-role-of-hierarchical-design-and-morphology-in-the-mechanical-response-of-diatom-inspired-structures-via-simulation
#18
Alejandro Gutiérrez, Metin G Guney, Gary K Fedder, Lilian P Dávila
Diatoms are microscopic algae with intricate shell morphologies and features ranging from the nanometer to the micrometer scale, which have been proposed as templates for drug delivery carriers, optical devices, and metamaterials design. Several studies have found that diatom shells show unique mechanical properties such as high specific strength and resilience. One hypothesis is that these properties stem from the structural arrangement of the material at the nanometer and micrometer length scales, challenging the concept between what constitutes a "material" versus a "structure"...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29147713/variation-of-the-bone-forming-ability-with-the-physicochemical-properties-of-calcium-phosphate-bone-substitutes
#19
Rongquan Duan, Davide Barbieri, Xiaoman Luo, Jie Weng, Chongyun Bao, Joost D de Bruijn, Huipin Yuan
Because of their bioactive properties and chemical similarity to the inorganic component of bone, calcium phosphate (CaP) materials are widely used for bone regeneration. Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicron-scale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model. After 12 weeks of implantation in the paraspinal muscle of four beagles, sporadic bone (0...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29142997/advanced-smart-photosensitizers-for-more-effective-cancer-treatment
#20
Wooram Park, Soojeong Cho, Jieun Han, Heejun Shin, Kun Na, Byeongdu Lee, Dong-Hyun Kim
Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects...
November 16, 2017: Biomaterials Science
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