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Biomaterials Science

Fabio Salvatore Palumbo, Calogero Fiorica, Giovanna Pitarresi, Massimiliano Zingales, Emanuela Bologna, Gaetano Giammona
A hyaluronic acid derivative that is able to physically crosslink in a saline aqueous environment was employed for the production of fibers with a mean diameter of 50 μm using a microfluidic technique. The microfibers were collected in a tailored rotating collector and assembled to form multifibrillar bundles. The orientation of the microfibers on the collected bundles was evaluated by microCT analysis. The bundles were biofunctionalized by physical addition of fibronectin or chemical tethering of a cyRGDC peptide to achieve control of Aortic Smooth Muscle Cell (AoSMC) attachment, elongation and alignment...
August 9, 2018: Biomaterials Science
Guanning Huang, Zumei Liu, Lizhen He, Kar-Him Luk, Siu-To Cheung, Ka-Hing Wong, Tianfeng Chen
Selenium nanoparticles (SeNPs) have attracted much interest as potential anticancer nanodrugs. Our previous studies also demonstrated that SeNPs could be developed as carriers of clinically used anticancer drugs to achieve synergistic efficacy. Here, we describe the synthesis of Pleurotus tuber-regium (PTR)-conjugated SeNPs (PTR-SeNPs) and their application in the treatment of colorectal cancer (CRC), which is one of the principal causes of cancer morbidity and mortality in the world. PTR-SeNPs were absorbed by cancer cells via clathrin-mediated endocytosis into lysosomes and caveolae-mediated endocytosis into the Golgi apparatus...
August 9, 2018: Biomaterials Science
Yang Shu, Yuanman Yu, Shuang Zhang, Jing Wang, Yin Xiao, Changsheng Liu
The immunomodulatory property of biomaterials is vital in determining the in vivo fate of implants and tissue regeneration. Bone morphogenetic protein-2 (BMP-2) has been identified as an effective inducer of osteogenic differentiation for bone repair. But it is still unclear how the immunomodulatory effects of materials impact on BMP-2-mediated osteogenesis. Herein, this study aims to investigate the immunoregulatory role of 2-N,6-O-sulfated chitosan (26SCS), a sulfated polysaccharide, in the osteogenetic capacity of BMP-2 and the subsequent effects on bone regeneration...
August 9, 2018: Biomaterials Science
Zhuojun Huang, Peyman Delparastan, Patrick Burch, Jing Cheng, Yi Cao, Phillip B Messersmith
We report here the development of hydrogels formed at physiological conditions using PEG (polyethylene glycol) based polymers modified with boronic acids (BAs) as backbones and the plant derived polyphenols ellagic acid (EA), epigallocatechin gallate (EGCG), tannic acid (TA), nordihydroguaiaretic acid (NDGA), rutin trihydrate (RT), rosmarinic acid (RA) and carminic acid (CA) as linkers. Rheological frequency sweep and single molecule force spectroscopy (SMFS) experiments show that hydrogels linked with EGCG and TA are mechanically stiff, arising from the dynamic covalent bond formed by the polyphenol linker and boronic acid functionalized polymer...
August 2, 2018: Biomaterials Science
Hui Zhi, Xu Fei, Jing Tian, Liyuan Zhao, Haiyang Zhang, Muzi Jing, Longquan Xu, Yi Wang, Yao Li
In this work, Eu-containing poly (vinyl acetate) and poly (vinyl alcohol) are made into triple physical cross-linked hydrogels. The hydrogels exhibit good tensile strength, ultrahigh toughness, excellent compressive recovery and identifiability. The superior mechanical properties of the hydrogels originate from the synergetic interactions of hydrogen bonding, molecular crystals, and hydrophobic interactions. The hydrogels are identifiable due to the introduction of the Eu(iii) organic complex [Eu(DBM)2(Phen)MA] into vinyl acetate and the identifiability of the hydrogel proves the uniformity of two types of polymers (Eu-PVAc and PVA) in the hydrogels...
August 1, 2018: Biomaterials Science
Xiuhua Wang, Lei Tan, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin W K Yeung, Paul K Chu, Shuilin Wu
Near infrared (NIR) light induced photodynamic antibacterial therapy (PDAT) is a promising antibacterial technique in rapid in situ disinfection of bacterially infected artificial implants due to its penetration ability into tissues. However, the lower oxygen content in vivo may restrict the yields of reactive oxygen species (ROS), thus reducing the antibacterial efficacy of PADT significantly. Herein, liposome encapsulated photosensitizers (PS), IR780 and perfluorohexane (PFH), have been constructed on the surface of Ti implants via a covalent linkage to overcome this issue...
August 1, 2018: Biomaterials Science
Qiyu Zhu, Ming Jiang, Qiang Liu, Shina Yan, Longbao Feng, Yong Lan, Guiqiu Shan, Wei Xue, Rui Guo
Burn wounds are associated with a series of risks, such as infection and pathologic scar tissue formation, which significantly delay wound healing and lead to complications. In this study, we successfully fabricated a dextran-hyaluronic acid (Dex-HA) hydrogel enriched with sanguinarine (SA) incorporated into gelatin microspheres (GMs), which had high porosity, good swelling ratio, enhanced NIH-3T3 fibroblast cell proliferation, and sustained SA release profile. The in vitro degradation results indicate that the SA/GMs/Dex-HA hydrogel can be degraded...
August 1, 2018: Biomaterials Science
Vivianne Chappuis, Laura Maestre, Alexander Bürki, Sébastien Barré, Daniel Buser, Philippe Zysset, Dieter Bosshardt
Advances in biomaterials science and implant surface technology have made dental implants more predictable and implant therapy more attractive to patients. Surgical interventions are becoming less invasive, and patients heal faster and suffer less morbidity. In this preclinical in vivo study, we compared a new ultra-fine grained titanium (ufgTi) implant material with a hydrophilic nano-patterned surface to commercially pure titanium (cpTi) in a well-established animal model. CpTi grade 4 was subjected to Equal Channel Angular Pressing (ECAP), followed by a cold drawing process that provided ultra-fine-grained titanium (ufgTi) with a mean grain size of 300 nm...
August 1, 2018: Biomaterials Science
Yamin Li, Justin Bolinger, Yingjie Yu, Zachary Glass, Nicola Shi, Liu Yang, Ming Wang, Qiaobing Xu
CRISPR/Cas9 ribonucleoprotein (RNP) complexes with transient therapeutic activity and minimum off-target effects have attracted tremendous attention in recent years for genome editing and have been successfully employed in diverse targets. One ongoing challenge is how to transport structurally and functionally intact Cas9 protein and guide RNA molecules into cells efficiently and safely. Here we report a combinatorial library of disulfide bond-containing cationic lipidoid nanoparticles (LNPs) as carrier systems for intracellular Cas9/sgRNA delivery and subsequent genome editing...
July 31, 2018: Biomaterials Science
A Merlo, V R S S Mokkapati, S Pandit, I Mijakovic
Boron nitride has structural characteristics similar to carbon 2D materials (graphene and its derivatives) and its layered structure has been exploited to form different nanostructures such as nanohorns, nanotubes, nanoparticles and nanosheets. Unlike graphene and other carbon based 2D materials, boron nitride has a higher chemical stability. Owing to these properties, boron nitride has been used in different applications as a filler, lubricant and as a protective coating. Boron nitride has also been applied in the biomedical field to some extent, but far less than other 2D carbon materials...
July 30, 2018: Biomaterials Science
Antonietta Restuccia, Gregory A Hudalla
Carbohydrate-modified biomaterials are attractive candidates for disrupting natural protein-glycan binding events because they present ligands in multivalent arrangements that can address the weak affinity of monovalent protein-carbohydrate interactions. However, protein binding depends on physical aspects of immobilized carbohydrate display, such as density and valency, which are often difficult to predict and can vary for different types of biomaterials. Here, we report on protein interactions with β-sheet peptide nanofibers with tunable immobilized carbohydrate content, which were prepared by co-assembling QQKFQFQFEQQ (Q11) with a glycosylated variant modified with N-acetylglucosamine (GQ11) at different molar ratios...
July 30, 2018: Biomaterials Science
Georgia Petrou, Thomas Crouzier
Mucins are large glycoproteins that are ubiquitous in the animal kingdom. Mucins coat the surfaces of many cell types and can be secreted to form mucus gels that assume important physiological roles in many animals. Our growing understanding of the structure and function of mucin molecules and their functionalities has sparked interest in investigating the use of mucins as building blocks for innovative functional biomaterials. These pioneering studies have explored how new biomaterials can benefit from the barrier properties, hydration and lubrication properties, unique chemical diversity, and bioactivities of mucins...
July 26, 2018: Biomaterials Science
Akshita Kumar, Harini Mohanram, Kiat Whye Kong, Rubayn Goh, Shawn Hoon, Julien Lescar, Ali Miserez
Suckerin proteins are a family of block co-polymer-like structural proteins that self-assemble into robust supramolecular structures - the sucker ring teeth (SRT) - which are located on the arms and tentacles of cephalopods and used to firmly capture preys. Suckerins are promising biomimetic protein-based biopolymers, but the supramolecular interactions stabilizing SRT remain unknown. Here, we report multi-dimensional Nuclear Magnetic Resonance (NMR) spectroscopy structural studies of an engineered suckerin protein composed of two main sequence modules...
July 25, 2018: Biomaterials Science
Hong Yang, Xue Shen, Jie Yan, Xiaoxue Xie, Zhongyuan Chen, Tingting Li, Shun Li, Xiang Qin, Chunhui Wu, Yiyao Liu
The efficacy of cancer chemotherapy can be generally restrained by the multiple drug resistance (MDR) of tumors, which is typically attributed to the upregulation of ATP-binding cassette (ABC) transporter proteins, such as P-glycoprotein (P-gp). There is an urgent need to present innovative strategies to reverse MDR and enhance the therapeutic efficacy of chemotherapeutic agents in biomedical applications. Here, we report a novel nanosystem of charge-reversal-functionalized PLGA nanobubbles (denoted as Dox-NBs/PPP/P-gp shRNA) for the co-delivery of Dox and P-gp shRNA for the reversal of drug resistance and for ultrasonic-imaging-guided tumor therapy...
July 24, 2018: Biomaterials Science
He-Lin Xu, Bi-Xin Shen, Meng-Ting Lin, Meng-Qi Tong, Ya-Wen Zheng, Xue Jiang, Wai-Geng Yang, Jian-Dong Yuan, Qing Yao, Ying-Zheng Zhao
Currently, phototherapy initiated by local irradiation with a near-infrared (NIR) laser has emerged as a promising strategy for cancer treatment owing to its low toxicity. However, a key problem for effective phototherapy is how to specifically deliver a sufficient dose of photosensitizers to a tumor focus. Herein, indocyanine green (ICG), a United States Food and Drug Administration (US FDA)-approved photosensitizer, was first encapsulated in an inner aqueous compartment of liposome (ICG-LIP) to improve its stability...
July 24, 2018: Biomaterials Science
Hélène Lajous, Raphaël Riva, Bénédicte Lelièvre, Clément Tétaud, Sylvie Avril, François Hindré, Frank Boury, Christine Jérôme, Philippe Lecomte, Emmanuel Garcion
Glioblastoma is the most frequent and aggressive primary malignant tumor of the central nervous system with a gloomy prognosis. Platinum derivatives and one among them, cisplatin, exhibited promising results when locally administered into the brain of glioblastoma bearing rats. Nanovectorization of anticancer agents through polymeric nanoparticles may even promote drug accumulation within cells, thus concentrating the drug efficiently at its target. Anchorage of gadolinium complexes on the corona of such smart drug delivery systems could further allow magnetic resonance imaging (MRI) monitoring of the nanoplatform biodistribution in the damaged parenchyma and its therapeutic benefit...
July 19, 2018: Biomaterials Science
Mostak Ahmed, Laura G Carrascosa, Alain Wuethrich, Paul Mainwaring, Matt Trau
It is a well-known phenomenon that cancer cells release key biological information such as DNA, RNA or proteins into body fluids (e.g., blood, urine or saliva). The analysis of these molecules-often encapsulated within nanovesicules called exosomes-is highly attractive, because it could replace current surgical biopsies, which are painful, costly and potentially risky for patients. For example, current strategies in lung cancer diagnosis involve genetic analyses from tumour tissues to detect the presence of underlying DNA mutations, known to alter the phosphorylation status and function of proteins...
July 19, 2018: Biomaterials Science
Zifei Zhou, Xifeng Liu, Wei Wu, Sungjo Park, A Lee Miller Ii, Andre Terzic, Lichun Lu
Biomimetic biomaterials require good biocompatibility and bioactivity to serve as appropriate scaffolds for tissue engineering applications. Recent developments demonstrated that the unique properties of carbon nanotubes (CNTs) can enhance neural cell growth and axon organization. We previously developed a promising nerve conduit manufactured from biodegradable polycaprolactone fumarate (PCLF) for use in peripheral nerve regeneration applications. In the present study, we fabricated conductive PCLF-CNT scaffolds using ultraviolet (UV) induced photocrosslinking...
July 18, 2018: Biomaterials Science
Dong Zhang, Jincheng Yang, Jibin Guan, Bin Yang, Shenwu Zhang, Mengchi Sun, Ruitao Yang, Tao Zhang, Ruoshi Zhang, Qiming Kan, Haotian Zhang, Zhonggui He, Lei Shang, Jin Sun
Prodrug self-nanoassemblies have many advantages for anticancer drug delivery, including high drug loading rate, resistance to recrystallization, and on-demand drug release. However, few studies have focused on their protein corona, which is inevitably formed after entering the blood and determines their subsequent fates in vivo. To actively tune the protein corona of prodrug nanoassemblies, three maleimide-paclitaxel prodrugs were synthesized via different redox-sensitive linkers (ester bond, thioether bond and disulfide bond)...
July 18, 2018: Biomaterials Science
Lina Dong, Wenyan Wang, Jinghuang Chen, Xingwei Ding, Bixing Fang, Xinxin Miao, Yu Liu, Fen Yu, Hongbo Xin, Xiaolei Wang
Inherent highly ordered anisotropic aerogels were prepared through a facile celery-carbonization process. The subsequent modification of silver nanowire knitted nets endowed the prepared carbonaceous aerogel with several valuable properties, including broad-spectrum antibacterial activity, near-infrared responsive heating, lightweight cushioning and anisotropic pressure-sensitive conductivity. With the aid of 3D printing technology, this versatile material could be applied as an ultralight monitor to realize the visualized detection of different physiological activities, such as ankle movements and cardiac arrhythmias...
July 18, 2018: Biomaterials Science
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