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Biomaterials Science

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https://www.readbyqxmd.com/read/28726876/bioceramic-nanocomposite-thiol-acrylate-polyhipe-scaffolds-for-enhanced-osteoblastic-cell-culture-in-3d
#1
Aaron Lee, Caitlin R Langford, Luis M Rodriguez-Lorenzo, Helmut Thissen, Neil R Cameron
Emulsion-templated (polyHIPE) scaffolds for bone tissue engineering were produced by photopolymerisation of a mixture of trimethylolpropane tris(3-mercaptopropionate) and dipentaerythritol penta-/hexa-acrylate in the presence of hydroxyapatite (HA) or strontium-modified hydroxyapatite (SrHA) nanoparticles. Porous and permeable polyHIPE materials were produced regardless of the type or incorporation level of the bioceramic, although higher loadings resulted in a larger average pore diameter. Inclusion of HA and SrHA into the scaffolds was confirmed by EDX-SEM, FTIR and XPS and quantified by thermogravimetry...
July 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28726855/cyclodextrin-based-biological-stimuli-responsive-carriers-for-smart-and-precision-medicine
#2
Rongqiang Liao, Pin Lv, Qian Wang, Jiaoni Zheng, Bing Feng, Bo Yang
Spurred on by recent progress in nanotechnology and precision medicine, smart drug carriers are entering an entirely new era. Smart drug carriers have been widely studied in recent years as a result of their ability to control drug release under different microenvironments (such as pH, redox, and enzyme) in vivo. Host-guest interactions based on cyclodextrins have proven to be an efficient tool for fabricating smart drug carriers. Because of the application of host-guest interactions, many kinds of biological molecules or supramolecular building blocks can combine into an organic whole at the molecular level...
July 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28722727/biomaterials-science-emerging-investigators-2017
#3
EDITORIAL
Sarah Heilshorn, Jun Wang
No abstract text is available yet for this article.
July 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28722044/tripartite-polyionic-complex-pic-micelles-as-non-viral-vectors-for-mesenchymal-stem-cell-sirna-transfection
#4
Sophie Raisin, Marie Morille, Claire Bony, Danièle Noël, Jean-Marie Devoisselle, Emmanuel Belamie
In the context of regenerative medicine, the use of RNA interference mechanisms has already proven its efficiency in targeting specific gene expression with the aim of enhancing, accelerating or, more generally, directing stem cell differentiation. However, achievement of good transfection levels requires the use of a gene vector. For in vivo applications, synthetic vectors are an interesting option to avoid possible issues associated with viral vectors (safety, production costs, etc.). Herein, we report on the design of tripartite polyionic complex micelles as original non-viral polymeric vectors suited for mesenchymal stem cell transfection with siRNA...
July 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28717800/from-molecules-to-macrostructures-recent-development-of-bioinspired-hard-tissue-repair
#5
REVIEW
Chunmei Ding, Zhuoxin Chen, Jianshu Li
Enamel, dentin and bone are calcified hard tissues in the human body that play significant roles in food mastication and movement support. Generally, hard tissues lack the ability of self-repair, except for the regeneration ability of bone for small-scale defects. Fabrication of man-made repair materials is therefore highly demanded. In this review, following a bioinspired strategy, we describe the composition and multiscale structures of different hard tissues, and highlight the key points for the reconstruction of hard tissues...
July 18, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28715515/surgical-suture-releasing-macrophage-targeted-drug-loaded-nanoparticles-for-an-enhanced-anti-inflammatory-effect
#6
Hansol Kim, Byung Hwi Kim, Beom Kang Huh, Yeon Chun Yoo, Chan Yeong Heo, Young Bin Choy, Ji-Ho Park
A surgical suture is a medical device to close the wound site of skin and organs but excessive inflammation surrounding the suture can disrupt the wound healing process. Although post-operative prescription of anti-inflammatory drugs is used to manage the inflammation, the need for local drug delivery systems has been rising because of low bioavailability and fast clearance of drugs. In this work, we proposed a new strategy for a local anti-inflammatory device by incorporating macrophage-targeted anti-inflammatory nanoparticles into the suture...
July 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28715029/anisotropic-microfibrous-scaffolds-enhance-the-organization-and-function-of-cardiomyocytes-derived-from-induced-pluripotent-stem-cells
#7
Maureen Wanjare, Luqia Hou, Karina H Nakayama, Joseph J Kim, Nicholas P Mezak, Oscar J Abilez, Evangeline Tzatzalos, Joseph C Wu, Ngan F Huang
Engineering of myocardial tissue constructs is a promising approach for treatment of coronary heart disease. To engineer myocardial tissues that better mimic the highly ordered physiological arrangement and function of native cardiomyocytes, we generated electrospun microfibrous polycaprolactone scaffolds with either randomly oriented (14 μm fiber diameter) or parallel-aligned (7 μm fiber diameter) microfiber arrangement and co-seeded the scaffolds with human induced pluripotent stem cell-derived cardiomyocytes (iCMs) and endothelial cells (iECs) for up to 12 days after iCM seeding...
July 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28715002/cationic-folate-mediated-liposomal-delivery-of-bis-arylidene-oxindole-induces-efficient-melanoma-tumor-regression
#8
Chandra Kumar Elechalawar, Kathyayani Sridharan, Abhishek Pal, Mohammed Tanveer Ahmed, Mohammed Yousuf, Susanta Sekhar Adhikari, Rajkumar Banerjee
The folate receptor (FR) is a well-validated and common target for cancer due to its high over-expression in many different cancer cells. Herein, we developed a new FR-targeting ligand (FA8) by conjugating folic acid and a cationic lipid. Owing to its favorable structural property FA8 as a ligand could be accommodated at an unusually higher molar ratio for a ligand-targeted liposome. We then encapsulated a drug-like molecule, bis-arylidene oxindole (NME2), in the targeted liposome. The resulting formulation induced potent caspase-8 up-regulation even in FR-moderately expressing melanoma cells...
July 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28692083/using-biomaterials-to-rewire-the-process-of-wound-repair
#9
REVIEW
Anna Stejskalová, Benjamin D Almquist
Wound healing is one of the most complex processes that our bodies must perform. While our ability to repair wounds is often taken for granted, conditions such as diabetes, obesity, or simply old age can significantly impair this process. With the incidence of all three predicted to continue growing into the foreseeable future, there is an increasing push to develop strategies that facilitate healing. Biomaterials are an attractive approach for modulating all aspects of repair, and have the potential to steer the healing process towards regeneration...
July 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28686244/3d-printed-porous-ceramic-scaffolds-for-bone-tissue-engineering-a-review
#10
REVIEW
Yu Wen, Sun Xun, Meng Haoye, Sun Baichuan, Chen Peng, Liu Xuejian, Zhang Kaihong, Yang Xuan, Peng Jiang, Lu Shibi
This study summarizes the recent research status and development of three-dimensional (3D)-printed porous ceramic scaffolds in bone tissue engineering. Recent literature on 3D-printed porous ceramic scaffolds was reviewed. Compared with traditional processing and manufacturing technologies, 3D-printed porous ceramic scaffolds have obvious advantages, such as enhancement of the controllability of the structure or improvement of the production efficiency. More sophisticated scaffolds were fabricated by 3D printing technology...
July 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28686242/keratin-dissolution-extraction-and-biomedical-application
#11
REVIEW
Amin Shavandi, Tiago H Silva, Adnan A Bekhit, Alaa El-Din A Bekhit
Keratinous materials such as wool, feathers and hooves are tough unique biological co-products that usually have high sulfur and protein contents. A high cystine content (7-13%) differentiates keratins from other structural proteins, such as collagen and elastin. Dissolution and extraction of keratin is a difficult process compared to other natural polymers, such as chitosan, starch, collagen, and a large-scale use of keratin depends on employing a relatively fast, cost-effective and time efficient extraction method...
July 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28681888/gemcitabine-camptothecin-conjugates-a-hybrid-prodrug-for-controlled-drug-release-and-synergistic-therapeutics
#12
Meili Hou, Peng Xue, Yong-E Gao, Xiaoqian Ma, Shuang Bai, Yuejun Kang, Zhigang Xu
Drug self-delivery systems represent an important approach to enhance the therapeutic efficacy for cancer therapy. We report the design, synthesis and characterization of a new amphiphilic small molecule prodrug based on two types of anticancer drugs, the hydrophilic gemcitabine and hydrophobic camptothecin, linked by a disulfide bond and abbreviated as GT-CPT. The obtained amphiphilic prodrug conjugates self-assembled into nanoparticles in water and showed strong micellar stability and excellent blood compatibility in vivo...
July 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28681887/manipulating-tumor-hypoxia-toward-enhanced-photodynamic-therapy-pdt
#13
Juanjuan Dang, Hua He, Donglai Chen, Lichen Yin
Photodynamic therapy (PDT) is considered a promising approach for the treatment of cancer and is achieved via the photosensitizer (PS)-mediated incomplete reduction of oxygen upon light irradiation, which generates high levels of reactive oxygen species (ROS) to induce potent vascular damage and to directly kill tumor cells. However, there is an undesirable impediment with this approach in that tumor tissues generally suffer from serious hypoxia, which significantly affects the efficiency of PDT. Additionally, PDT that consumes oxygen will further aggravate tumor hypoxia, thus potentially leading to multiple undesirable consequences, such as angiogenesis, tumor invasiveness, and tumor metastasis...
July 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28676877/novel-fibrous-collagen-based-cream-accelerates-fibroblast-growth-for-wound-healing-applications-in-vitro-and-in-vivo-evaluation
#14
Sivalingam Udhayakumar, Krishnakumar Gopal Shankar, Sampath Sowndarya, Chellan Rose
The present study reports the development of a novel film-forming bovine collagenous cream (BCC) based on bovine collagen (BC). In this study, collagen was isolated from bovine forestomach tissue, a novel source, and a cream formulation was prepared using some other bioactive ingredients. The electrophoretic pattern of the BC was found to be similar to type I collagen. The purity of BC was examined by amino acid analysis, which confirmed the presence of atelocollagen. The physicochemical properties of BCC such as rheology, spreadability, and temperature stability were characterized...
July 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28676875/fibroblast-fate-regulation-by-time-dependent-tgf-%C3%AE-1-and-il-10-stimulation-in-biomimetic-3d-matrices
#15
Jiranuwat Sapudom, Xiancheng Wu, Marina Chkolnikov, Michael Ansorge, Ulf Anderegg, Tilo Pompe
The presentation of TGF-β1 during the early stage of wound healing is a prerequisite for extracellular matrix (ECM) synthesis and remodeling by activated fibroblasts, called myofibroblasts. At later stages, clearance of myofibroblasts is needed to avoid overshooting ECM production. Apoptosis of myofibroblasts and the macrophage-released anti-inflammatory cytokine IL-10 are controversially discussed as regulating cues in this context. To reveal the regulating cues, defined biomaterial scaffolds are needed to conduct in-depth in vitro studies in a physiologically relevant context...
July 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28676873/design-preparation-and-performance-of-a-novel-drug-eluting-stent-with-multiple-layer-coatings
#16
Tingzhang Hu, Song Lin, Ruolin Du, Meiling Fu, Qiong Rao, Tieying Yin, Yan Huang, Guixue Wang
Drug-eluting stents (DESs) can effectively control the harmful effects of coronary artery disease, because of their excellent ability to reduce in-stent restenosis. However, delayed re-endothelialization and late stent thrombosis have caused concern over the safety of DESs. In this study, according to time-ordered pathological responses after stent implantation, a hierarchical multiple drug-eluting stent was designed and prepared to overcome the existing DES limitations. A platelet membrane glycoprotein IIIa monoclonal antibody (SZ-21) and a vascular endothelial growth factor (VEGF121) were loaded into the inner coating of 316L stainless steel (316L SS) stents to inhibit thrombosis and promote re-endothelialization; rapamycin (RAPA) was loaded into the third layer to inhibit intima hyperplasia; a drug-free poly-l-lactic acid coating was located on the second and fourth layers and used as sustained release layers...
July 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28676869/impact-of-the-biomolecular-corona-on-the-structure-of-pegylated-liposomes
#17
Luca Digiacomo, Daniela Pozzi, Heinz Amenitsch, Giulio Caracciolo
Driven by the promises of gene therapy, PEGylated cationic liposomes (CLs) have been investigated for decades, but their use in the clinical setting is far from established. Such a dichotomy is due to several factors that have been ignored over the last two decades. The hardest challenge seems to occur when PEGylated CLs come into contact with a physiological environment (e.g. the blood). Recent evidence has demonstrated that PEGylation does not completely prevent protein binding (as believed so far), but a biomolecular shell, termed "biomolecular corona" (BC), covers the liposome surface...
July 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28675203/electrospun-poly-n-isopropyl-acrylamide-poly-caprolactone-fibers-for-the-generation-of-anisotropic-cell-sheets
#18
Alicia C B Allen, Elissa Barone, Cody O Keefe Crosby, Laura J Suggs, Janet Zoldan
Cell alignment in muscle, nervous tissue, and cartilage is requisite for proper tissue function; however, cell sheeting techniques using the thermosensitive polymer poly(N-isopropyl acrylamide) (PNIPAAm) can only produce anisotropic cell sheets with delicate and resource-intensive modifications. We hypothesized that electrospinning, a relatively simple and inexpensive technique to generate aligned polymer fibers, could be used to fabricate anisotropic PNIPAAm and poly(caprolactone) (PCL) blended surfaces that both support cell viability and permit cell sheet detachment via PNIPAAm dissolution...
July 4, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28664207/recent-progress-in-nanomedicine-based-combination-cancer-therapy-using-a-site-specific-co-delivery-strategy
#19
REVIEW
Shiyang Shen, Meng Liu, Teng Li, Shiqi Lin, Ran Mo
Combination cancer therapy possesses considerable appeal due to its many merits such as enhancing efficacy by synergistic effects and overcoming drug resistance as compared to monotherapy. Nanomedicine-mediated co-delivery of multiple anticancer agents is more effective than conventional cocktail-based physical mixture of free drugs. A strategy is required to differentiate their unique targets for maximizing the synergistic effects based on individual sites of action of different drugs. This review summarizes the recent progresses in nanomedicine-based combination cancer therapies using site-specific co-delivery strategies, which have been classified by different target sites at the anatomical scales such as tissue, cellular and subcellular levels...
June 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28664205/synthesis-of-controlled-high-molecular-weight-poly-l-glutamic-acid-brush-polymers
#20
Ryan Baumgartner, Diane Kuai, Jianjun Cheng
We report the synthesis and characterization of high-molecular weight poly(l-glutamic acid) based brush polymers. Utilizing a combination of ring-opening metathesis polymerization of norbornene based monomers and ring-opening polymerization of γ-benzyl-l-glutamate N-carboxyanhydride, high-molecular weight γ-benzyl protected poly(l-glutamic acid) brush polymers are synthesized. Controlled and complete deprotection of the benzyl groups using trimethylsilyl iodide resulted in poly(l-glutamic acid) based brush polymers with molecular weights up to 3...
June 30, 2017: Biomaterials Science
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