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Biomaterials Science

Xianfang Jiang, Junting Liu, Qin Liu, Zhenhui Lu, Li Zheng, Jinmin Zhao, Xingdong Zhang
Correction for 'Therapy for cartilage defects: functional ectopic cartilage constructed by cartilage-simulating collagen, chondroitin sulfate and hyaluronic acid (CCH) hybrid hydrogel with allogeneic chondrocytes' by Xianfang Jiang et al., Biomater. Sci., 2018, 6, 1616-1626.
June 21, 2018: Biomaterials Science
Fabrizio A Pennacchio, Costantino Casale, Francesco Urciuolo, Giorgia Imparato, Raffaele Vecchione, Paolo A Netti
In tissue engineering there is growing interest in fabricating highly engineered platforms designed to instruct cells towards the synthesis of tissues that reproduce their natural counterpart. In this context, a fundamental factor to take into account is the control over the final tissue orientation, especially for what concerns the replication of load-bearing tissues whose functions are strictly related to their microstructural organization. Starting from this point, in this work we have engineered a gelatin-based hydrogel in order to be patterned by 2-photon polymerization (2PP) lithography for the fabrication of instructive free standing building blocks designed to produce anisotropic collagen-based μtissues...
June 21, 2018: Biomaterials Science
Purva Kodlekere, L Andrew Lyon
We demonstrate the utility of microgel core/shell structures conjugated to fibrin-specific peptides as fibrinolytic agents. Poly(N-isopropylmethacrylamide) (pNIPMAm) based microgels conjugated to the peptide GPRPFPAC (GPRP) were observed to bring about fibrin clot erosion, merely through exploitation of the dynamic nature of the clots. These results suggest the potential utility of peptide-microgel hybrids in clot disruption and clotting modulation.
June 20, 2018: Biomaterials Science
Ru-Yi Yu, Lei Xing, Peng-Fei Cui, Jian-Bin Qiao, Yu-Jing He, Xin Chang, Tian-Jiao Zhou, Qing-Ri Jin, Hu-Lin Jiang, Yanyu Xiao
Finding a cure for breast cancer currently remains a medical challenge in due to the failure of common treatment methods to inhibit invasion and metastasis of cancer cells, which eventually leads to recurrence of breast cancer. Many secreted proteins are overexpressed and play crucial roles in tumorigenesis and development. The Golgi apparatus is a key protein processing and secretion factory in which metastasis-associated proteins are modified, transported and secreted; thus, regulating the Golgi apparatus of tumor cells is a viable strategy to inhibit tumor metastasis...
June 20, 2018: Biomaterials Science
Yu-Li Chen, Feng-Qiu Liu, Yuan Guo, Juan Cheng, Lu Yang, Min Lu, Pan Li, Jie Xu, Tao Yu, Zhi-Gang Wang, Yang Cao, Hai-Tao Ran
Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclerotic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a novel polymeric nanosystem that encapsulates phthalocyanine zinc (ZnPc) and perfluorohexane (PFH) was developed to target the new blood vessels of breast tumors. After being conjugated to the anti-VEGFR-2 antibody, the polymeric nanoparticles (NPs) targeted vascular endothelial cells efficiently...
June 19, 2018: Biomaterials Science
Xiao-Jiao Du, Ze-Yu Wang, Yu-Cai Wang
The development of delivery systems for small interfering RNA (siRNA) plays a key role in its clinical application. As the major delivery systems for siRNA, cationic polymer- or lipid-based vehicles are plagued by inherent issues. As proof of concept, a disulfide bond-containing amphiphilic Janus dendrimer (ssJD), which could be conveniently synthesized and readily scaled up with high reproducibility, was explored as a siRNA delivery system to circumvent these issues. The cationic hydrophilic head of this Janus dendrimer ensured strong and stable binding with negatively charged siRNA via electrostatic interactions, and the loaded siRNA was rapidly released from the obtained complexes under a redox environment...
June 14, 2018: Biomaterials Science
Francielle Pelegrin Garcia, Marlène Rippe, Mychelle V P Companhoni, Talitha Fernandes Stefanello, Benoit Louage, Simon Van Herck, Lucie Sancey, Jean-Luc Coll, Bruno G De Geest, Celso Vataru Nakamura, Rachel Auzély-Velty
The development of biopolymer-based nanogels has gained particular interest to achieve successful delivery of therapeutics for the treatment of various diseases, such as cancer, infection and diabetes. Herein, we report a new and simple methodology for the covalent stabilization of self-assembled gel nanoparticles based on hyaluronic acid (HA) modified with a thermoresponsive ketone-functional copolymer. This relies on the selective formation of hydrazone crosslinks with bishydrazides within the globular domains of the copolymer chains formed above the cloud point temperature...
June 14, 2018: Biomaterials Science
Esra Türker, Nida Demirçak, Ahu Arslan-Yildiz
Correction for 'Scaffold-free three-dimensional cell culturing using magnetic levitation' by Esra Türker et al., Biomater. Sci., 2018, DOI: 10.1039/c8bm00122g.
June 14, 2018: Biomaterials Science
Rui Zhang, Caitlin N Leeper, Xiaofei Wang, Tommi A White, Bret D Ulery
Two different vasoactive intestinal peptide (VIP) amphiphiles have been formulated which readily form micelles of varying shapes. Interestingly, VIP micelle structure has been found to directly correlate to anti-inflammatory behavior providing evidence that these biomaterials can serve as a promising new therapeutic modality.
June 13, 2018: Biomaterials Science
Mu Li, Xiangmei Liu, Lei Tan, Zhenduo Cui, Xianjin Yang, Zhaoyang Li, Yufeng Zheng, Kelvin Wai Kwok Yeung, Paul K Chu, Shuilin Wu
Bacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99...
June 8, 2018: Biomaterials Science
Natalya Doroshenko, Stephen Rimmer, Richard Hoskins, Prashant Garg, Thomas Swift, Hannah L M Spencer, Rianne M Lord, Maria Katsikogianni, David Pownall, Sheila MacNeil, C W Ian Douglas, Joanna Shepherd
Microbial keratitis can arise from penetrating injuries to the cornea. Corneal trauma promotes bacterial attachment and biofilm growth, which decrease the effectiveness of antimicrobials against microbial keratitis. Improved therapeutic efficacy can be achieved by reducing microbial burden prior to antimicrobial therapy. This paper assesses a highly-branched poly(N-isopropyl acrylamide) with vancomycin end groups (HB-PNIPAM-van), for reducing bacterial attachment and biofilm formation. The polymer lacked antimicrobial activity against Staphylococcus aureus, but significantly inhibited biofilm formation (p = 0...
June 8, 2018: Biomaterials Science
Byungseop Yang, Jong Chul Kim, Jihyoun Seong, Giyoong Tae, Inchan Kwon
Human serum albumin (HSA) has been investigated as a serum half-life extender of therapeutic proteins thanks to its unusually long serum half-life. However, in mice, the serum half-life of a HSA-conjugated protein was much shorter than that of HSA in humans, likely due to the species-dependent nature of albumin-FcRn interactions. Herein, we investigated species-dependent albumin-FcRn interactions using species-matched albumin (mouse serum albumin) and species-mismatched albumin (HSA) in non-transgenic mice...
June 8, 2018: Biomaterials Science
Yihua Liu, Maria Chiara Munisso, Atsushi Mahara, Yusuke Kambe, Kyoko Fukazawa, Kazuhiko Ishihara, Tetsuji Yamaoka
An effective surface grafting method for chemically inert and elaborately porous medical expanded-polytetrafluoroethylene (ePTFE) was developed. Although surface graft polymerization onto basic polymeric biomaterials has been widely studied, successful modification of the ePTFE surface has been lacking due to its high chemical resistance. Herein, we succeeded in surface graft polymerization onto ePTFE through glycidyl methacrylate (GMA) as a bridge linkage following argon (Ar) plasma treatment. The epoxy group of GMA was expected to react with the peroxide groups produced on ePTFE by Ar plasma exposure, and its methacrylic groups can copolymerize with various monomers...
June 7, 2018: Biomaterials Science
Zhicheng Pan, Danxuan Fang, Yuanqing Song, Nijia Song, Mingming Ding, Jiehua Li, Feng Luo, Jianshu Li, Hong Tan, Qiang Fu
Cationic gemini quaternary ammonium (GQA) has been used as a cell internalization promoter to improve the permeability of the cell membrane and enhance the cellular uptake. However, the effect of the alkyl chain length on the cellular properties of nanocarriers has not been elucidated yet. In this study, we developed a series of polyurethane micelles containing GQAs with various alkyl chain lengths. The alteration of the gemini alkyl chain length was found to change the distribution of GQA surfactants in the micellar structure and affect the surface charge exposure, stability, and the protein absorption properties of nanocarriers...
June 6, 2018: Biomaterials Science
Erdong Li, Xiaju Cheng, Yaoyao Deng, Jing Zhu, Xiaoding Xu, Phei Er Saw, Hongwei Gu, Cuicui Ge, Yue Pan
Nanocomposites for integrating imaging and therapy have attracted tremendous attention for biomedical applications. Herein, Fe@Bi2S3 nanocomposites modified with polyethylene glycol (PEG) molecules are fabricated for synergistic thermoradiotherapy. For such nanocomposites, Bi2S3 exhibits a strong absorbance in the near-infrared (NIR) region, which allows Bi2S3 to convert energy from light into heat for effective photothermal therapy (PTT), whereas Bi can also significantly enhance radio-mediated cell death induction as a radiotherapy sensitizer due to its high atomic number (high-Z)...
June 5, 2018: Biomaterials Science
Hao-Wei Lee, Ya-Chuan Hsiao, Tai-Horng Young, Tsung-Lin Yang
Correction for 'Maintenance of the spheroid organization and properties of glandular progenitor cells by fabricated chitosan based biomaterials' by Hao-Wei Lee et al., Biomater. Sci., 2018, DOI: 10.1039/c7bm00559h.
June 1, 2018: Biomaterials Science
Wenxin Zhang, Yang Zhou, Xudong Li, Xin Xu, Yongbing Chen, Rongying Zhu, Lichen Yin
As one of the intractable challenges in the clinic, the treatment of acute liver failure (ALF) is limited due to high mortality and resource cost. RNA interference (RNAi) provides a new modality for the anti-inflammatory therapy of ALF, while its therapeutic efficacy is greatly hampered by the lack of effective carriers to cooperatively overcome the various systemic barriers. Herein, we developed macrophage-targeting and reactive oxygen species (ROS)-responsive polyplexes to enable efficient systemic delivery of TNF-α siRNA (siTNF-α) to attenuate hepatic inflammation in mice bearing ALF...
June 1, 2018: Biomaterials Science
Vasiliki P Koidou, Prokopios P Argyris, Erik P Skoe, Juliana Mota Siqueira, Xi Chen, Lei Zhang, James E Hinrichs, Massimo Costalonga, Conrado Aparicio
There is a critical need for preventing peri-implantitis as its prevalence has increased and dental implants lack features to prevent it. Research strategies to prevent peri-implantitis have focused on modifying dental implants to incorporate different antimicrobial agents. An alternative strategy consists of barring the expansion of the biofilm subgingivally by forming a long-lasting permucosal seal between the soft tissue and the implant surface. Here, we innovatively biofunctionalized titanium with bioinspired peptide coatings to strengthen biological interactions between epithelial cells and the titanium surface...
May 31, 2018: Biomaterials Science
Fang-Yi Su, Jasmin Chen, Hye-Nam Son, Abby M Kelly, Anthony J Convertine, T Eoin West, Shawn J Skerrett, Daniel M Ratner, Patrick S Stayton
Pulmonary intracellular infections, such as tuberculosis, anthrax, and tularemia, have remained a significant challenge to conventional antibiotic therapy. Ineffective antibiotic treatment of these infections can lead not only to undesired side effects, but also to the emergence of antibiotic resistance. Aminoglycosides (e.g., streptomycin) have long been part of the therapeutic regiment for many pulmonary intracellular infections. Their bioavailability for intracellular bacterial pools, however, is limited by poor membrane permeability and rapid elimination...
May 31, 2018: Biomaterials Science
Maria P Sousa, Ana I Neto, Tiago R Correia, Sónia P Miguel, Michiya Matsusaki, Ilídio J Correia, João F Mano
Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN). Freestanding multilayer membranes without DN are also produced as a control. The success of the synthesis of HA-DN was confirmed using UV-visible spectroscopy. Scanning electron microscopy images indicate that the surface of the DN-containing membranes is more porous than the control ones; they also present a higher average thickness value for the same number of CHT/ALG/CHT/HA(-DN) tetralayers (n = 100)...
May 31, 2018: Biomaterials Science
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