Read by QxMD icon Read

Biomaterials Science

Ya-Ting Tsai, Chao-Wei Huang, Hui-Yu Liu, Mei-Ching Huang, Ting-Pi Sun, Wen-Chien Chen, Chih-Yu Wu, Shih-Torng Ding, Hsien-Yeh Chen
The ability to induce osteointegration was introduced to a parylene-C surface via the simple and intuitive process of protein adsorption mediated by hydrophobic interactions. In this way, bone morphogenetic protein (BMP)-2, fibronectin, and platelet-rich plasma (PRP) could be immobilized on parylene-C surfaces. This approach alleviates concerns related to the use of potentially harmful substances in parylene-C modification processes. The adsorbed protein molecules were quantitatively characterized with respect to adsorption efficacy and binding affinity, and the important biological activities of the proteins were also examined using both early and late markers of osteogenetic activity, including alkaline phosphatase expression, calcium mineralization and marker gene expression...
October 26, 2016: Biomaterials Science
Bailiang Wang, Zi Ye, Qingwen Xu, Huihua Liu, Quankui Lin, Hao Chen, Kaihui Nan
Once a biomedical implant is implanted into a human body, proteins and bacteria can easily colonize the implant, and subsequently, a biofilm can grow on the surface. A biofilm can protect the inhabiting bacteria against macrophages and neutrophil cell attack from the host immune system. The most important issue for artificial antibacterial surfaces is the accumulation of the bacteria corpse after they are killed by contact, which promotes further adhesion of bacteria and biofilm formation. Therefore, we constructed a novel multifunctional bactericidal and fouling release antibacterial surface through the combination of temperature-responsive N-vinylcaprolactam (VCL), hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) and a bactericidal quaternary ammonium salt (2-(dimethylamino)-ethyl methacrylate (DMAEMA(+)))...
October 26, 2016: Biomaterials Science
Mthulisi Khuphe, Clare S Mahon, Paul D Thornton
The glucoseamine-initiated ring-opening polymerisation of amino acid N-carboxyanhydrides and O-carboxanhydrides to yield amphiphilic block copolymers that are capable of self-assembly in aqueous solution to form well-defined, glucose-presenting, particles is reported. The particles formed are susceptible to enzyme-mediated (lipase and protease) and pH-induced degradation, and can selectively bind the lectin concanavalin A. Consequently, such glycoparticles are of significance for the controlled release of payload molecules in response to an acidic environment, for instance cancerous tissue, and upon interaction with target enzymes...
October 25, 2016: Biomaterials Science
Abdul K Parchur, Qifei Li, Anhong Zhou
We report the synthesis, characterization, and application of Prussian blue (PB) functionalized CaMoO4:Eu@SiO2@Au nanorod hybrid nanoparticles (HNPs), with multimodal capabilities such as fluorescence imaging, surface-enhanced Raman spectroscopy (SERS) detection and photothermal therapy (PTT). The average size of CaMoO4:Eu@SiO2 NPs was 206 nm. The HNPs are highly dispersible in water for several weeks without settling and show a strong absorption in the near-infrared region, overlapping with the PB absorption between 600 nm and 1000 nm and the surface plasmon resonance of Au nanorods around 800 nm...
October 21, 2016: Biomaterials Science
Sarah A Altınoğlu, Ming Wang, Kathleen Q Li, Yuyang Li, Qiaobing Xu
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor, mutated or inactive in a large percentage of human cancers. Restoring PTEN activity in cancer cells through gene therapy has shown to inhibit cell growth and induce apoptosis, particularly in cells with a PTEN deficiency. Gene therapy, however, comes with some inherent risks such as triggering an immune response and permanent off target effects. Nanoparticle assisted protein delivery could mitigate these liabilities while maintaining therapeutic integrity...
October 17, 2016: Biomaterials Science
Suhas Ramesh, Marcelo Grijalva, Alexis Debut, Beatriz G de la Torre, Fernando Albericio, Luis H Cumbal
Nanotechnology is gaining impetus in the present century and particularly the use of nanoparticles (NPs), whose properties are significantly different from the larger matter. These have found wider and potential applications in the fields of medicine, energy, cosmetics, environment and biomedicine. Among the NPs, silver nanoparticles (AgNPs) are of particular interest for scientists and technologists due to their unique physico-chemical and biological properties. Besides, AgNPs by themselves also possess broad-spectrum microbial activity, which has further expanded their application in both academia and industries...
October 17, 2016: Biomaterials Science
Yeji Kim, Julie C Liu
Peripheral artery disease often requires treatments with vascular grafts for vessel reconstruction. Endothelialization of the vascular grafts is important to achieve long-term patency because endothelial cells regulate thrombosis, inflammation, and growth of smooth muscle cells. One potential source of endothelial cells is human mesenchymal stem cells (hMSCs), which can be routinely differentiated towards the endothelial lineage using exogenous growth factors such as vascular endothelial growth factor (VEGF)...
October 12, 2016: Biomaterials Science
Yang J Xu, Kongchang Wei, Pengchao Zhao, Qian Feng, Chun Kit K Choi, Liming Bian
Mussel adhesion has inspired the development of catechol-based adhesive polymers. However, conventional strategies require basic pH conditions and lead to the loss of adhesion. To solve the problem, we report the first attempt to use thiourea-functionalized polymers for preserving hydrogel adhesion. We believe that this simple thiourea-quinone coupling chemistry is instrumental to synthetic adhesive materials.
October 10, 2016: Biomaterials Science
Pei-Chi Lee, Chien-Yu Lin, Cheng-Liang Peng, Ming-Jium Shieh
The development of a controlled-release drug delivery system has been an important objective for cancer therapy. To achieve the goal of sustained drug release for preventing the biotoxicity of platinum drugs, oxaliplatin was encapsulated into PEGylated multiwalled carbon nanotubes (MWNTs) decorated with superparamagnetic iron oxide (SPIO) for magnetic resonance imaging (MRI). The superparamagnetic properties and purification of SPIO/MWNT composites were achieved by annealing treatment during the fabrication process; the better hydrophilicity and biocompatibility were also accomplished subsequently after modification with polyethylene glycol (PEG)...
October 7, 2016: Biomaterials Science
(no author information available yet)
No abstract text is available yet for this article.
November 18, 2016: Biomaterials Science
Paolo Giannoni, Federico Villa, Cinzia Cordazzo, Luciano Zardi, Paolo Fattori, Rodolfo Quarto, Mauro Fiorini
Three different heterologous substitutes for bone regeneration, manufactured with equine-derived cortical powder (CP), cancellous chips (CC) and demineralized bone matrix granules (DBM), were compared in in vitro and in vivo settings. We tested: a commercially available bone paste (Osteoplant-Activagen™, consisting of aqueous collagenous carrier, CP, DBM; named A); a second-generation injectable paste (20 kDa polyethylene glycol/hydroxypropyl-methyl cellulose-based hydrogel, CP, DBM; B); a pre-formed bone filler (400 kDa polyethylene oxide/hydroxypropyl-methyl cellulose-based hydrogel, CP, CC, DBM; C)...
November 18, 2016: Biomaterials Science
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2016: Biomaterials Science
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2016: Biomaterials Science
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2016: Biomaterials Science
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2016: Biomaterials Science
A Tan, K Fujisawa, Y Yukawa, Y T Matsunaga
We developed a robust bottom-up approach to construct open-ended, tubular co-culture constructs that simulate the human vascular morphology and microenvironment. By design, these three-dimensional artificial vessels mimic the basic architecture of an artery: a collagen-rich extracellular matrix (as the tunica externa), smooth muscle cells (SMCs) (as the tunica media), and an endothelial cell (EC) lining (as the tunica interna). A versatile needle-based fabrication technique was employed to achieve controllable arterial layouts within a PDMS-hosted collagen microchannel scaffold (330 ± 10 μm in diameter): (direct co-culture) a SMC/EC bilayer to follow the structure of an arteriole-like segment; and (encapsulated co-culture) a lateral SMC multilayer covered by an EC monolayer lining to simulate the architecture of a larger artery...
October 20, 2016: Biomaterials Science
Zujian Feng, Junqiang Zhao, Yin Li, Shuxin Xu, Junhui Zhou, Jianhua Zhang, Liandong Deng, Anjie Dong
Thermo-sensitive injectable hydrogels based on poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) block copolymers have attracted considerable attention for sustained drug release and tissue engineering applications. Previously, we have reported a thermo-sensitive hydrogel of P(CL-co-TOSUO)-PEG-P(CL-co-TOSUO) (PECT) triblock copolymers modified by hydrophilic cyclic ether pendant groups 1,4,8-trioxa-[4.6]spiro-9-undecanone (TOSUO). Unfortunately, the low gel modulus of PECT (only 50-70 Pa) may limit its applications...
October 20, 2016: Biomaterials Science
Zhihong Wang, Wenting Zheng, Yifan Wu, Jianing Wang, Xiuyuan Zhang, Kai Wang, Qiang Zhao, Deling Kong, Tingyu Ke, Chen Li
Great progress has been made in the field of vascular tissue engineering, with some artificial vascular grafts already exhibiting promising outcomes in animal models. However, these studies were mostly conducted using healthy animals, which are not representative of actual clinical demands. Indeed, patients who require artificial vascular graft implantation are often accompanied by other comorbidities, such as hyperlipidaemia, hypertension and diabetes which should also be taken into consideration when assessing the potential of vascular grafts that are intended for clinical applications...
October 20, 2016: Biomaterials Science
Wenjie Sun, Jia Yang, Jianzhi Zhu, Yiwei Zhou, Jingchao Li, Xiaoyue Zhu, Mingwu Shen, Guixiang Zhang, Xiangyang Shi
We report the design of iron oxide (Fe3O4) nanoparticle (NP)-immobilized alginate (AG) nanogels (NGs) as a novel contrast agent for enhanced magnetic resonance (MR) imaging applications. In this study, an aqueous solution of AG activated by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride was double emulsified to form NGs, followed by in situ cross-linking with polyethyleneimine (PEI)-coated Fe3O4 NPs (PEI-Fe3O4 NPs). The resultant Fe3O4 NP-immobilized AG NGs (AG/PEI-Fe3O4 NGs) were characterized via different techniques...
October 20, 2016: Biomaterials Science
Wang Ding, Kailash Chandra Gupta, Soo-Young Park, Young-Kyoo Kim, Inn-Kyu Kang
The present study utilizes antibody-protein interactions to develop an LC microdroplet based biosensor for naked eye detection of SK-BR3 human breast cancer cells. The herceptin antibody-conjugated LC microdroplets were fabricated using 4-cyano-4'-pentyl biphenyl (5CB) as the liquid crystalline phase and sodium dodecyl sulfate (SDS) as the surfactant. The poly (styrene-b-acrylic acid) amphiphilic block copolymer (PS-b-PA) played a role as a modifier for the liquid crystalline interfaces. The 5CB molecules in the herceptin antibody-conjugated LC microdroplets have shown an orientation transition from radial to bipolar on selective interactions with targeted SK-BR3 breast cancer cells, which are over expressed by the human epidermal growth factor receptor 2-positive (HER2)...
October 20, 2016: Biomaterials Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"