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Biomaterials Science

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https://www.readbyqxmd.com/read/28530743/multicellular-tumor-invasion-and-plasticity-in-biomimetic-materials
#1
Susan E Leggett, Amanda S Khoo, Ian Y Wong
Cancer cell invasion through the extracellular matrix is associated with metastatic spread and therapeutic resistance. In carcinomas, the detachment and dissemination of individual cells has been associated with an epithelial-mesenchymal transition, but tumors can also invade using collective, multicellular phenotypes. This malignant tumor progression is also associated with alignment and stiffening of the surrounding extracellular matrix. Historically, tumor invasion has been investigated using 2D monolayer culture, small animal models or patient histology...
May 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28518205/self-assembly-of-amphiphilic-tripeptides-with-sequence-dependent-nanostructure
#2
Jugal Kishore Sahoo, Calvin Nazareth, Michael A VandenBerg, Matthew J Webber
Supramolecular chemistry enables the creation of a diversity of nanostructures and materials. Many of these have been explored for applications as biomaterials and therapeutics. Among them, self-assembling peptides have been broadly applied. The structural diversity afforded from the library of amino acid building blocks has enabled control of emergent properties across length-scales. Here, we report on a family of amphiphilic tripeptides with sequence-controlled nanostructure. By altering one amino acid in these peptides, we can produce a diversity of nanostructures with different aspect-ratio and geometry...
May 18, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28516997/peptide-and-antibody-ligands-for-renal-targeting-nanomedicine-strategies-for-kidney-disease
#3
Jonathan Wang, Jacqueline J Masehi-Lano, Eun Ji Chung
The kidney is one of the body's main filtration organs, and hence, opportunity exists for designing nanomedicine that can naturally accumulate in the kidneys for renal diseases. In addition to traditional physiochemical properties for kidney accumulation, such as size and charge, synthesized nanoparticles can be conjugated with targeting ligands which further home the nanocarriers to cell types of interest. In this review, we highlight key studies that have shown success in utilizing peptide- or antibody-based ligands in nanoparticles to target the glomerulus, podocytes, or renal tubule cells in the kidney...
May 18, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28516182/intracellular-accumulation-and-immunological-responses-of-lipid-modified-magnetic-iron-nanoparticles-in-mouse-antigen-processing-cells
#4
Chenmeng Qiao, Jun Yang, Lei Chen, Jie Weng, Xin Zhang
Understanding the effects of magnetic iron nanoparticles (MINPs) on the immune response is vitally important for biomedical applications such as cancer therapy, disease diagnosis and novel cancer imaging. In this study, lipid modified MINPs were designed and prepared by introducing the neutral lipid DSPE-PEG or the zwitterionic lipid DSPE-PCB into hydrophobic MINPs through hydrophobic interaction (L-MINPs and ZL-MINPs, respectively). The effect of L-MINPs and ZL-MINPs on the intracellular accumulation and immune responses of three kinds of antigen processing cells was examined...
May 18, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28513659/serum-resistant-reactive-oxygen-species-ros-potentiated-gene-delivery-in-cancer-cells-mediated-by-fluorinated-diselenide-crosslinked-polyplexes
#5
Qiurong Deng, Xudong Li, Lipeng Zhu, Hua He, Donglai Chen, Yongbing Chen, Lichen Yin
The transfection performance of polycations is often hampered by various systemic barriers that pose conflicting requirements for material design. Herein, we developed fluorinated, ROS-cleavable polyethylenimine (PEI) for effective and serum-resistant gene delivery to cancer cells, by harmonizing the inconsistency between DNA condensation and release, and the inconsistency between cellular internalization and serum stability. Low-molecular weight (MW) PEI was cross-linked with a diselenide-containing linker and further modified with fluorocarbon chains...
May 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28513656/restoring-the-biophysical-properties-of-decellularized-patches-through-recellularization
#6
Gigi Chi Ting Au-Yeung, Udi Sarig, Hadar Sarig, Hanumakumar Bogireddi, Tomer Bronshtein, Limor Baruch, Avihai Spizzichino, Jacob Bortman, Boey Yin Chiang Freddy, Marcelle Machluf, Subbu S Venkatraman
Various extracellular matrix (ECM) scaffolds, isolated through decellularization, were suggested as ideal biomimetic materials for 'Functional tissue engineering' (FTE). The decellularization process comprises a compromise between damaging and preserving the ultrastructure and composition of ECM-previously shown to affect cell survival, proliferation, migration, organization, differentiation and maturation. Inversely, the effects of cells on the ECM constructs' biophysical properties, under physiological-like conditions, remain still largely unknown...
May 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28509913/optimization-of-a-polydopamine-pd-based-coating-method-and-polydimethylsiloxane-pdms-substrates-for-improved-mouse-embryonic-stem-cell-esc-pluripotency-maintenance-and-cardiac-differentiation
#7
Jiayin Fu, Yon Jin Chuah, Wee Tong Ang, Nan Zheng, Dong-An Wang
Myocardiocyte derived from pluripotent stem cells, such as induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), is a promising cell source for cardiac tissue engineering. Combined with microfluidic technologies, a heart-on-a-chip is very likely to be developed and function as a platform for high throughput drug screening. Polydimethylsiloxane (PDMS) silicone elastomer is a widely-used biomaterial for the investigation of cell-substrate interactions and biochip fabrication. However, the intrinsic PDMS surface hydrophobicity inhibits cell adhesion on the PDMS surface, and PDMS surface modification is required for effective cell adhesion...
May 16, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28503689/effects-of-elemene-on-inhibiting-proliferation-of-vascular-smooth-muscle-cells-and-promoting-reendothelialization-at-the-stent-implantation-site
#8
Wenjie Sun, Yuhua Huang, Tieying Yin, Jingjing Wang, Ruolin Du, Juhui Qiu, Yuan Zhang, Yazhou Wang, Jinju Chen, Guixue Wang
Anticancer drugs are commonly used as inhibitors of vascular smooth muscle cell (VSMC) proliferation in clinical treatments. This study aims to investigate how elemene affects the proliferation of VSMCs, the restenosis, and the reendothelialization after implanting the elemene-coated stents. VSMCs derived from rat aorta were used to test the cell proliferation, cell cycle, migration, apoptosis, cytoskeletal protein F-actin, intracellular Ca(2+), IncRNA chip and gene expression of PCNA, P53, and Cx43 when cultured with elemene...
May 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28498385/polymer-brushes-based-on-plla-b-peo-colloids-for-the-preparation-of-protein-resistant-pla-surfaces
#9
E Mázl Chánová, O Pop-Georgievski, M M Kumorek, O Janoušková, L Machová, D Kubies, F Rypáček
In this study we investigate the formation of protein-resistant polymer surfaces, such as aliphatic polyesters, through the deposition of self-assemblies of amphiphilic poly(l-lactide)-b-poly(ethylene oxide), PLLA-b-PEO, copolymers as stable nanoparticles with a kinetically frozen PLLA core on model PLLA surfaces. The length of the PEO chains in the corona was tuned to achieve polymer brushes capable of preventing protein adsorption on PLA-based biomaterials. The spectroscopic ellipsometry, IR and XPS analysis, contact angle goniometry, and AFM proved that the PEO chains adopted a brush structure and were preferably exposed on the surface...
May 12, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28485431/skin-safe-photothermal-therapy-enabled-by-responsive-release-of-acid-activated-membrane-disruptive-polymer-from-polydopamine-nanoparticle-upon-very-low-laser-irradiation
#10
Rui Zhu, Feng Gao, Ji-Gang Piao, Lihua Yang
How to ablate tumor without damaging skin is a challenge for photothermal therapy. We, herein, report skin-safe photothermal cancer therapy provided by the responsive release of acid-activated hemolytic polymer (aHLP) from the photothermal polydopamine (PDA) nanoparticle upon irradiation at very low dosage. Upon skin-permissible irradiation (via an 850 nm laser irradiation at the power density of 0.4 W cm(-2)), the nanoparticle aHLP-PDA generates sufficient localized-heat to bring about mild hyperthermia treatment and consequently, responsively sheds off the aHLP polymer from its PDA nanocore; this leads to selective cytotoxicity to cancer cells under the acidic conditions of the extracellular microenvironment of tumor...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28484754/dual-modal-imaging-guided-highly-efficient-photothermal-therapy-using-heptamethine-cyanine-conjugated-hyaluronic-acid-micelles
#11
Sanpeng Li, Zhihong Sun, Guanjun Deng, Xiaoqing Meng, Wenjun Li, Dapeng Ni, Jiali Zhang, Ping Gong, Lintao Cai
Targeted phototherapy and multi-modal imaging can effectively improve the therapeutic efficacy and reduce the side effects of theranostics. Herein, we constructed novel biocompatible cyanine dye IR808-conjugated hyaluronic acid nanoparticles (HAIR NPs) for photothermal therapy (PTT) with near-infrared fluorescence (FL) and photoacoustic (PA) dual-modal imaging. The nanoparticles formed stable nanostructures under aqueous conditions with uniform size distribution. The HAIR NPs were rapidly taken up by the human lung cancer cells A549 via CD44 (the hyaluronic acid receptor on the surface of tumor cells) receptor-mediated endocytosis...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28484751/bioapplications-of-renal-clearable-luminescent-metal-nanoparticles
#12
REVIEW
Lingshan Gong, Yaping Wang, Jinbin Liu
Renal-clearable inorganic nanoparticles (NPs) that hold great potential in the future clinic translations are considered as the next generation of nanomedicine. In the past decade, enormous efforts have been dedicated to the development of renal-clearable NPs with fascinating optical properties, selective disease-targeting capabilities and low nanotoxicities. A further understanding of the design of renal-clearable luminescent metal NPs and their metabolic behavior in the body is important to achieve their clinical transition and extend their bioapplications in disease theranostics...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28474038/engineering-of-hemocompatible-and-antifouling-polyethersulfone-membranes-by-blending-with-heparin-mimicking-microgels
#13
Hai-Feng Ji, Lian Xiong, Zhen-Qiang Shi, Min He, Wei-Feng Zhao, Chang-Sheng Zhao
To improve the hemocompatibility and antifouling property of polyethersulfone (PES) membranes, heparin-mimicking microgels of poly(acrylic acid-co-N-vinyl-2-pyrrolidone) (P(AA-VP)) and poly(2-acrylamido-2-methylpropanesulfonic acid-co-acrylamide) (P(AMPS-AM)) were synthesized by conventional free radical copolymerization, and then incorporated into a PES matrix by blending. The results of Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and scanning electron microscopy (SEM) confirmed that heparin-mimicking microgels were successfully synthesized...
May 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28470226/flexible-and-highly-interconnected-multi-scale-patterned-chitosan-porous-membrane-produced-in-situ-from-mussel-shell-to-accelerate-wound-healing
#14
Xiaoping Song, Jie Mei, Xingying Zhang, Leyu Wang, Gurankit Singh, Malcolm M Q Xing, Xiaozhong Qiu
Utilization of the underlying mechanisms of biological systems is the principal endeavor of biomimetics, the primary goal of which is to treat on-going biological processes. From the perspective of tissue engineering, one purpose of biomimetics is to create highly cellular- or tissue-favored environments for bio-defect repair. Marine creatures such as mussels have inspired bioengineers to design ideal cellular substrates, strong adhesives, and other bioengineering materials. Herein, we report a novel mussel shell-derived membrane for wound dressing...
May 4, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28466898/enhanced-antibacterial-efficacy-of-nitric-oxide-releasing-thermoplastic-polyurethanes-with-antifouling-hydrophilic-topcoats
#15
Priyadarshini Singha, Jitendra Pant, Marcus J Goudie, Christina D Workman, Hitesh Handa
Surface fouling is one of the leading causes of infection associated with implants, stents, catheters, and other medical devices. The surface chemistry of medical device coatings is important in controlling and/or preventing fouling. In this study, we have shown that a combination of nitric oxide releasing hydrophobic polymer with a hydrophilic polymer topcoat can significantly reduce protein attachment and subsequently reduce bacterial adhesion as a result of the synergistic effect. Nitric oxide (NO) is a well-known potent antibacterial agent due to its adverse reactions on microbial cell components...
May 3, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28466896/non-sticky-and-antimicrobial-zwitterionic-nanocomposite-dressings-for-infected-chronic-wounds
#16
Kang-Ting Huang, Yun-Lung Fang, Pai-Shan Hsieh, Chun-Chang Li, Niann-Tzyy Dai, Chun-Jen Huang
Zwitterionic poly(sulfobetaine acrylamide) (pSBAA)-based nanocomposite hydrogels impregnated with germicidal silver nanoparticles (AgNPs) were synthesized and implemented for the treatment of infected chronic wounds. The zwitterionic hydrogels exhibited excellent non-sticky properties and had reinforced mechanical properties by the addition of hectorite nanoclay and poly(ethylene glycol)dimethacrylate as physical and chemical crosslinkers, respectively. In addition, AgNPs were grown within the intercalated clay/polymer structure by in situ free radical reduction, as confirmed by UV-vis spectroscopy and transmission electron microscopy (TEM)...
May 3, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28447671/the-scaffold-microenvironment-for-stem-cell-based-bone-tissue-engineering
#17
REVIEW
Zhichao Hao, Zhenhua Song, Jun Huang, Keqing Huang, Amanda Panetta, Zhipeng Gu, Jun Wu
Bone tissue engineering uses the principles and methods of engineering and life sciences to study bone structure, function and growth mechanism for the purposes of repairing, maintaining and improving damaged bone tissue. Scaffolds not only provide structural support for stem cells in cell adhesion and proliferation and bone formation, but also serve as a microenvironment for guiding stem cell differentiation and tissue regeneration and for controlling tissue structure. This review presents the research status of the scaffold microenvironment for bone-related stem cells based on bone tissue engineering...
April 27, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28429809/successful-pegylation-of-hollow-encapsulin-nanoparticles-from-rhodococcus-erythropolis-n771-without-affecting-their-disassembly-and-reassembly-properties
#18
Seiichi Sonotaki, Taku Takami, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Yoshihiko Murakami
We developed a hollow PEGylated encapsulin nanoparticle from Rhodococcus erythropolis N771. The hollow engineered encapsulin nanoparticles with His-Tag and Lys residues on the surface were constructed by means of genetic recombination. The Lys residues on the particle surface were successfully PEGylated with a PEG derivative, methoxy-PEG-SCM. Consequently, we demonstrated that the hollow PEGylated engineered encapsulin nanoparticle could successfully disassemble or reassemble even after PEGylation in the presence or absence of a protein denaturing agent...
April 21, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28425537/using-fluorescently-labeled-magnetic-nanocomposites-as-a-dual-contrast-agent-for-optical-and-magnetic-resonance-imaging
#19
Taofeng Zhu, Xiuqin Ma, Ruhua Chen, Zhijun Ge, Jun Xu, Xiaoke Shen, Lei Jia, Tao Zhou, Yifeng Luo, Tieliang Ma
Dual-modality imaging probes synergistically combine magnetic resonance (MR) and fluorescence into a single nanocomposite. This promising technique affords a new level of flexibility for molecular imaging uses in biomedical research. In this study, we report a new strategy for the synthesis of a novel attapulgite nanorod-based atta@Fe3O4@[Ru(bpy)2(fmp)]Cl2 nanocomposite (atta@Fe3O4@Ru NC). Our synthesized NC has both photoluminescent and magnetic properties, bright fluorescence, as well as significant magnetic resonance...
April 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28422200/enhancing-mri-of-liver-metastases-with-a-zwitterionized-biodegradable-dendritic-contrast-agent
#20
Xiaoxuan Zhou, Mingzhou Ye, Yuxin Han, Jianbin Tang, Yue Qian, Hongjie Hu, Youqing Shen
Metastasis is the main reason for cancer-associated mortality, and accurate diagnostic imaging of metastases is critical for the clinical administration and tailoring personalized treatments for metastatic tumors. However, magnetic resonance imaging of metastases in the liver is impeded by its low sensitivity because the currently used contrast agents accumulate in hepatocytes and Kupffer cells instead of cancer cells. Herein, a 4(th) generation zwitterionized biodegradable dendritic contrast agent (DCA) with a size of ca...
April 19, 2017: Biomaterials Science
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