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Biomaterials Science

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March 23, 2017: Biomaterials Science
Hong Yang, Yin Chen, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Xue Shen, Tingting Li, Shun Li, Chunhui Wu, Yiyao Liu
Multifunctional theranostics have offered some interesting new opportunities for cancer therapy and diagnosis in the last decade. Herein, magnetic mesoporous silica nanoparticles (M-MSNs) were designed and synthesized, then the photosensitizer chlorin e6 (Ce6) and antitumor drug doxorubicin (Dox) were adsorbed onto the M-MSNs. Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance...
March 22, 2017: Biomaterials Science
Jingyi Zong, Steven L Cobb, Neil R Cameron
Colloidal gold solutions have been used for centuries in a wide variety of applications including staining glass and in the colouring of ceramics. More recently, gold nanoparticles (GNPs) have been studied extensively due to their interesting size-dependent electronic and optical properties. GNPs can be functionalized easily with biomolecules that contain thiols, amines, or even phosphine moieties. For example, the reaction of thiol-containing peptides with GNPs has been used extensively to prepare novel hybrid materials for biomedical applications...
March 17, 2017: Biomaterials Science
Ying Yang, Yunlong Wang, Manzhou Zhu, Yan Chen, Yazhong Xiao, Yuhua Shen, Anjian Xie
A reduced graphene oxide (RGO)/gold nanorod (AuNR)/hydroxyapatite (HA) nanocomposite was designed and successfully synthesized for the first time. An anticancer drug, 5-fluorouracil (5FU), was chosen as a model drug to be loaded in RGO/AuNR/HA. The fabricated RGO/AuNR/HA-5FU showed robust, selective targeting and penetrating efficiency against HeLa cells due to the good compatibility and nontoxicity of HA, and showed excellent synergetic antitumor effects through combined chemotherapy (CT) by 5FU and photothermal therapy (PTT) by both RGO and AuNRs under near-infrared (NIR) laser irradiation...
March 16, 2017: Biomaterials Science
Xinyu Li, Dandan Sun, Xu Li, Dashuai Zhu, Zhenzhen Jia, Jiajia Jiao, Kai Wang, Deling Kong, Xin Zhao, Lin Xu, Qiang Zhao, Dongyan Chen, Xizeng Feng
Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene...
March 15, 2017: Biomaterials Science
Y Mizuno, R Mizuta, M Hashizume, T Taguchi
The aim of this study was the development of an innovative biocompatible sealant composed of Alaska pollock-derived gelatin partially modified with a dodecyl group (C12-ApGltn) and a poly(ethylene glycol)-based crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate. The burst strength of the developed sealants was measured using porcine aorta and rat lungs. The maximum burst strength of a C12-ApGltn-based sealant against the porcine aorta was 4-fold higher than that of an original ApGltn (Org-ApGltn)-based sealant...
March 15, 2017: Biomaterials Science
Md Hasan Turabee, Thavasyappan Thambi, Jae Seung Lym, Doo Sung Lee
Stimuli-responsive polypeptides are a promising class of biomaterials due to their tunable physicochemical and biological properties. Herein, a series of novel pH- and thermo-responsive block copolymers based on polypeptides were synthesized by ring-opening polymerization of γ-benzyl-l-glutamate-N-carboxyanhydride in the presence of poly(ethylene glycol)-diamine macroinitiator followed by aminolysis. The resulting polypeptide-based triblock copolymer, poly[(2-(dibutylamino)ethyl-l-glutamate)-co-(γ-benzyl-l-glutamate)]-poly(ethylene glycol)-b-poly[(2-(dibutylamino)ethyl-l-glutamate)-co-(γ-benzyl-l-glutamate)] (PNLG-co-PBLG-b-PEG-b-PBLG-co-PNLG), exists as a low viscous sol at low pH and temperature (≤pH 6...
March 13, 2017: Biomaterials Science
Sabyasachi Chakrabortty, Miguel Sison, Yuzhou Wu, Anita Ladenburger, Goutam Pramanik, Johannes Biskupek, Jerome Extermann, Ute Kaiser, Theo Lasser, Tanja Weil
We report a bioinspired multifunctional albumin derived polypeptide coating comprising grafted poly(ethylene oxide) chains, multiple copies of the HIV TAT derived peptide enabling cellular uptake as well as mitochondria targeting triphenyl-phosphonium (TPP) groups. Exploring these polypeptide copolymers for passivating gold nanoparticles (Au NPs) yielded (i) NIR-emitting markers in confocal microscopy and (ii) photo-thermal active probes in optical coherence microscopy. We demonstrate the great potential of such multifunctional protein-derived biopolymer coatings for efficiently directing Au NP into cells and to subcellular targets to ultimately probe important cellular processes such as mitochondria dynamics and vitality inside living cells...
March 10, 2017: Biomaterials Science
Feiya Xu, Min Hu, Chengcheng Liu, Seok Ki Choi
The worldwide increase in bacterial antibiotic resistance has led to a search for alternative antibacterial therapies. The present study reports the development of yolk-structured multifunctional up-conversion nanoparticles (UCNPs) that combine photodynamic and sonodynamic therapy for effective killing of antibiotic-resistant bacteria. The multifunctional nanoparticles (NPs) were achieved by enclosing hematoporphyrin monomethyl ether (HMME) into its yolk-structured up-conversion core and covalently linked rose bengal (RB) on its silica (SiO2) shell...
March 10, 2017: Biomaterials Science
Marwa Tallawi, Madeleine Opitz, Oliver Lieleg
Bacterial communities form biofilms on a wide range of surfaces by synthesizing a cohesive and protective extracellular matrix. The morphology, internal structure and mechanical stability of a biofilm are largely determined by its constituent polymers. In addition to mediating adhesion to surfaces, biofilms control the uptake of molecules and regulate the permeability of the matrix to gases and chemicals. Since biofilms can cause significant problems in both industrial and healthcare settings, there is great interest in developing strategies that either inhibit their formation or facilitate their elimination...
March 9, 2017: Biomaterials Science
A Forget, A L S Burzava, B Delalat, K Vasilev, F J Harding, A Blencowe, N H Voelcker
Cell aggregates reproduce many features of the natural architecture of functional tissues, and have therefore become an important in vitro model of tissue function. In this study, we present an efficient and rapid method for the fabrication of site specific functionalised poly(dimethylsiloxane) (PDMS) microwell arrays that promote the formation of insulin-producing beta cell (MIN6) aggregates. Microwells were prepared using an ice templating technique whereby aqueous droplets were frozen on a surface and PDMS was cast on top to form a replica...
March 9, 2017: Biomaterials Science
Parvesh Wadhwani, Nico Heidenreich, Benjamin Podeyn, Jochen Bürck, Anne S Ulrich
Peptide-coated nanoparticles are valuable tools for diverse biological applications, such as drug delivery, molecular recognition, and antimicrobial action. The functionalization of pre-fabricated nanoparticles with free peptides in solution is inefficient either due to aggregation of the particles or due to the poor ligand exchange reaction. Here, we present a one-pot synthesis for preparing gold nanoparticles with a homogeneous distribution that are covered in situ with cationic peptides in a site-selective manner via Cys-residue at the N-terminus...
March 9, 2017: Biomaterials Science
Carlo Pifferi, Nathalie Berthet, Olivier Renaudet
Cyclopeptides have been recently used successfully as carriers for the multivalent presentation of carbohydrate and peptide antigens in immunotherapy. Beside their synthetic versatility, these scaffolds are indeed interesting due to their stability against enzyme degradation and low immunogenicity. This mini-review highlights the recent advances in the utilization of cyclopeptides to prepare fully synthetic vaccines prototypes against cancers and pathogens.
March 9, 2017: Biomaterials Science
Xinye He, Ying Qu, Jinrong Peng, Tao Peng, Zhiyong Qian
Poly(methyl methacrylate) (PMMA) resin is widely used as a prosthetic and restorative biomaterial, such as in bone cement, denture base resin, etc. The flexural and compressive strength of a PMMA resin is of great concern and many approaches have been made to improve the flexural resistance and compressive strength of PMMA. To strengthen PMMA via high-performance (HP) fibers is a feasible way; however, the HP fibers are not very satisfactory in practice, with a complex handling process and esthetic concerns...
March 9, 2017: Biomaterials Science
Lijing Hao, Tianjie Li, Fan Yang, Naru Zhao, Fuzhai Cui, Xuetao Shi, Chang Du, Yingjun Wang
Osteopontin (OPN) is a key mediator of cell interactions with biomaterials. However, few studies have been dedicated to studying cell adhesion on OPN-adsorbed substrates with controlled charge and wettability. Here, amino-carboxyl (NH2/COOH) and hydroxyl-methyl (OH/CH3) mixed self-assembled monolayers (SAMs) of varying charges and wettability, respectively, were used as controllable model surfaces to study OPN adsorption and subsequent mesenchymal stem cell (MSC) adhesion. The amount of OPN adsorbed onto the NH2/COOH mixed SAMs appeared to monotonically depend on the surface charge, whereas only a moderately hydrophilic surface was conducive to OPN adsorption on OH/CH3 mixed SAMs...
March 8, 2017: Biomaterials Science
Yi Hu, Leilei Shi, Yue Su, Chuan Zhang, Xin Jin, Xinyuan Zhu
Fluorescent light-up probes with aggregation-induced emission (AIE) characteristics have been focused on recently. In this report, a new fluorescent probe, namely, DEVD-TPE, which consisted of the substrate peptide Asp-Glu-Val-Asp (DEVD) and the AIE reporter group tetraphenylethene (TPE), was developed for detecting caspase-3 in living cells. In a slightly alkaline solution, the DEVD-TPE probe displayed almost no fluorescence owing to the dynamic rotation of the phenyl rings in solution. However, DEVD-TPE exhibited significant fluorescence when it was cleaved by caspase-3, as well as when the reporter group TPE underwent aggregation...
March 7, 2017: Biomaterials Science
Yanxia Zhu, Jie Tan, Hongxia Zhu, Guangyao Lin, Fei Yin, Liang Wang, Kedong Song, Yiwei Wang, Guangqian Zhou, Weihong Yi
Injectable constructs for in vivo gelation have many advantages in the regeneration of degenerated nucleus pulposus. In this study, an injectable hydrogel consisting of chitosan (CS) and hyaluronic acid (HA) crosslinked with glycerol phosphate (GP) at different proportions (CS : GP : HA, 6 : 3 : 1, 5 : 3 : 2, 4 : 3 : 3, 3 : 3 : 4, 2 : 3 : 5, 1 : 3 : 6, V : V : V) was developed and employed as a delivery system for kartogenin (KGN), a biocompound that can activate chondrocytes...
March 6, 2017: Biomaterials Science
Jae Sung Lee, Xiaohua Yu, Amy J Wagoner Johnson, William L Murphy
Although calcium phosphate (CaP) binding peptides are used to link orthobiologics to orthopedic biomaterials, their binding stability in physiological environment is still unknown. In this study, we investigate the binding capability of a series of CaP-binding peptides and their binding stability in serum solutions, which are selected to resemble physiological conditions. The findings in this study may be applicable for designing robust orthobiologic delivery systems.
March 6, 2017: Biomaterials Science
Zexuan Ding, Peng Liu, Dehong Hu, Zonghai Sheng, Huqiang Yi, Guanhui Gao, Yayun Wu, Pengfei Zhang, Shaozhi Ling, Lintao Cai
Photodynamic therapy (PDT) is a site-specific treatment of cancer using much lower optical power densities with minimal nonspecific damage to normal tissues. To improve the therapeutic efficiency of PDT, we fabricated a multifunctional theranostic nanoparticle system (DSSCe6@Fe3O4 NPs) by loading Fe3O4 nanoparticles in redox-responsive chlorin e6 (Ce6)-conjugated dextran nanoparticles for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. The obtained DSSCe6@Fe3O4 NPs demonstrated a uniform nanospherical morphology consisting of Fe3O4 clusters...
March 3, 2017: Biomaterials Science
Gangwei Xu, Yulong Tan, Tiegang Xu, Di Yin, Mengyuan Wang, Mingwu Shen, Xiaofeng Chen, Xiangyang Shi, Xiaoyue Zhu
Circulating tumor cells (CTCs) are important markers of metastatic cancer. The isolation and detection of CTCs from peripheral blood provides valuable information for cancer diagnosis and precision medicine. However, cost-efficient targeted separation of CTCs of different origins with clinically significant specificity and efficiency remains a major challenge. In this study, a facile approach was developed to fabricate a thin sheet of hyaluronic acid (HA)-functionalized PLGA nanofibrous membrane and integrate it into a microfluidic chamber...
March 3, 2017: Biomaterials Science
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