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Clinical and Experimental Vaccine Research

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https://www.readbyqxmd.com/read/29399584/evaluation-of-two-different-enzyme-linked-immunosorbent-assay-for-severe-fever-with-thrombocytopenia-syndrome-virus-diagnosis
#1
Min-Ah Yu, Hye Won Jeong, Su-Jin Park, Young-Il Kim, Hyeok-Il Kwon, Eun-Ha Kim, Young-Jae Si, Kwang Min Yu, Norbert John Robles, Hae Jung Han, Young Ki Choi
To develop the large scale serological assay for severe fever with thrombocytopenia syndrome virus (SFTSV) infection, we evaluated two different enzyme-linked immunosorbent assay (ELISA) methods using nucleocapsid protein (NP) and Gn proteins of CB1 (genotype B) SFTSV strains. The NP-based ELISA tests showed more sensitive with broad cross-reactivity between two different genotype A and B strains compared with those of Gn-based ELISA tests. However, Gn-based ELISA showed more genotype specificity and specificity...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399583/status-of-group-b-streptococcal-vaccine-development
#2
Shun Mei Lin, Yong Zhi, Ki Bum Ahn, Sangyong Lim, Ho Seong Seo
Streptococcus agalactiae (group B streptococcus, GBS) is a leading causal organism of neonatal invasive diseases and severe infections in the elderly. Despite significant advances in the diagnosis and treatment of GBS infections and improvement in personal hygiene standards, this pathogen is still a global health concern. Thus, an effective vaccine against GBS would augment existing strategies to substantially decrease GBS infection. In 2014, World Health Organization convened the first meeting for consultation on GBS vaccine development, focusing on the GBS maternal immunization program, which was aimed at reducing infections in neonates and young infants worldwide...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399582/outbreak-investigation-of-pertussis-in-an-elementary-school-a-case-control-study-among-vaccinated-students
#3
Sukhyun Ryu, Joon Jai Kim, Meng-Yu Chen, Hyunju Jin, Hyun Kyung Lee, Byung Chul Chun
Purpose: A pertussis patient from an elementary school, in Gyeonggi Province, Korea, was notified to public health authority on July 25, 2017. Epidemiologic investigation was conducted to identify the magnitude, possible source of infection and risk factors for this outbreak on August 17, 2017. Materials and Methods: A case was defined as the school student experiencing cough for more than two weeks with or without paroxysmal, whoop, or post-tussive vomiting. Control was defined as the student polymerase chain reaction-negative at the school...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399581/efficacy-of-inactivated-variant-porcine-epidemic-diarrhea-virus-vaccines-in-growing-pigs
#4
Seung Heon Lee, Dong-Kun Yang, Ha-Hyun Kim, In-Soo Cho
Purpose: The first aim of this study was to develop a novel inactivated porcine epidemic diarrhea virus (PEDV) vaccine using the recently isolated Korean PEDV QIAP1401 strain and to evaluate its protective efficacy in growing pigs. The second was to determine the optimum adjuvant formulation of the inactivated PEDV vaccine that induces protection against viral challenge. Materials and Methods: To generate high titers of infectious PEDV, the QIAP1401 isolate was passaged in Vero cells...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399580/immunogenicity-of-the-nanovaccine-containing-intimin-recombinant-protein-in-the-balb-c-mice
#5
Zahra Sadat Hosseini, Jafar Amani, Fahimeh Baghbani Arani, Shahram Nazarian, Mohammad Javad Motamedi, Fatemeh Shafighian
Purpose: Escherichia coli O157:H7 is one of the most important pathogens which create hemorrhagic colitis and hemolytic uremic syndrome in human. It is one of the most prevalent causes of diarrhea leading to death of many people every year. The first diagnosed gene in the locus of enterocyte effacement pathogenicity island is eae gene. The product of this gene is a binding protein called intimin belonging to the group of external membrane proteins regarded as a good stimulants of the immune system...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399579/epidemiology-of-severe-fever-and-thrombocytopenia-syndrome-virus-infection-and-the-need-for-therapeutics-for-the-prevention
#6
REVIEW
Norbert John C Robles, Hae Jung Han, Su-Jin Park, Young Ki Choi
Over the past ten years there has been a marked increase in cases of severe fever and thrombocytopenia syndrome in East Asia. This tick-borne hemorrhagic fever presents along with clinical signs including high fever and leukopenia. In addition to humans, the virus has also been detected with shared genetic homology in farm animals including goats, cattle, horses, and pigs. Furthermore, several genotypes of severe fever and thrombocytopenia syndrome virus (SFTSV) are currently co-circulating between humans and animals...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399578/anti-infective-potential-of-catechins-and-their-derivatives-against-viral-hepatitis
#7
REVIEW
Jae-Min Song
Polyphenols including catechins from green tea ( Camellia sinensis ) have been reported to have anti-infective activities against a broad spectrum of viruses and other pathogens. During the last two decades, antiviral activities of catechins with different modes of action have been demonstrated on diverse families of viruses, such as human immunodeficiency virus, Herpes simplex virus, influenza virus, hepatitis B and C virus. In this study, we focused on the antiviral properties of catechins and their derivatives against viral hepatitis which have become a key public health issue due to their serious impact on human health with liver diseases...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399577/calcium-dependent-protein-kinases-are-potential-targets-for-toxoplasma-gondii-vaccine
#8
REVIEW
Masoud Foroutan, Fatemeh Ghaffarifar
Toxoplasma gondii belongs to the Apicomplexa phylum that caused a widespread zoonotic infection in wide range of intermediate hosts. Over one-third of the world's population are latently infected with T. gondii and carry it. The complex life cycle of T. gondii indicates the presence of a plurality of antigenic epitopes. During the recent years, continuous efforts of scientists have made precious advances to elucidate the different aspects of the cell and molecular biology of T. gondii . Despite of great progresses, the development of vaccine candidates for preventing of T...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399576/distinct-features-of-dendritic-cell-based-immunotherapy-as-cancer-vaccines
#9
REVIEW
Chaelin Lee, Myungmi Lee, Inmoo Rhee
Dendritic cells (DCs) are the most professional antigen presenting cells that play important roles in connection between innate and adaptive immune responses. Numerous studies revealed that the functions of DCs are related with the capture and processing of antigen as well as the migration to lymphoid tissues for the presenting antigens to T cells. These unique features of DCs allow them to be considered as therapeutic vaccines that can induce immune responses and anti-tumor activity. Here, we discuss and understand the immunological basis of DCs and presume the possibilities of DC-based vaccines for the promising cancer therapy...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29399575/challenges-of-influenza-a-viruses-in-humans-and-animals-and-current-animal-vaccines-as-an-effective-control-measure
#10
REVIEW
Sung J Yoo, Taeyong Kwon, Young S Lyoo
Influenza A viruses (IAVs) are genetically diverse and variable pathogens that share various hosts including human, swine, and domestic poultry. Interspecies and intercontinental viral spreads make the ecology of IAV more complex. Beside endemic IAV infections, human has been exposed to pandemic and zoonotic threats from avian and swine influenza viruses. Animal health also has been threatened by high pathogenic avian influenza viruses (in domestic poultry) and reverse zoonosis (in swine). Considering its dynamic interplay between species, prevention and control against IAV should be conducted effectively in both humans and animal sectors...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168175/preparation-and-immunogenicity-of-influenza-virus-like-particles-using-nitrocellulose-membrane-filtration
#11
Young Chan Park, Jae Min Song
PURPOSE: Nitrocellulose membrane-based filtration system (NCFS) is widely used for protein concentration. In this study, we applied NCFS for production of virus-like particle (VLP) as a vaccine candidate and evaluated yield property and immunogenicity. MATERIALS AND METHODS: Influenza VLPs were generated by baculovirus-insect cell protein expression system. NCFS and sucrose gradient ultracentrifugation were used for purification of VLP. Immunogenicity of VLP was evaluated by animal experiment...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168174/sh2-domain-containing-adaptor-protein-b-expressed-in-dendritic-cells-is-involved-in-t-cell-homeostasis-by-regulating-dendritic-cell-mediated-th2-immunity
#12
Md Selim Ahmed, Myeong-Ho Kang, Ezra Lee, Yujin Park, Yideul Jeong, Yong-Soo Bae
PURPOSE: The Src homology 2 domain-containing adaptor protein B (SHB) is widely expressed in immune cells and acts as an important regulator for hematopoietic cell function. SHB silencing induces Th2 immunity in mice. SHB is also involved in T-cell homeostasis in vivo. However, SHB has not yet been studied and addressed in association with dendritic cells (DCs). MATERIALS AND METHODS: The effects of SHB expression on the immunogenicity of DCs were assessed by Shb gene silencing in mouse bone marrow-derived DCs (BMDCs)...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168173/trivalent-m-related-protein-as-a-component-of-next-generation-group-a-streptococcal-vaccines
#13
Harry S Courtney, Shannon E Niedermeyer, Thomas A Penfound, Claudia M Hohn, Adam Greeley, James B Dale
PURPOSE: There is a need to broaden protective coverage of M protein-based vaccines against group A streptococci (GAS) because coverage of the current 30-valent M protein vaccine does not extend to all emm types. An additional GAS antigen and virulence factor that could potentially extend vaccine coverage is M-related protein (Mrp). Previous work indicated that there are three structurally related families of Mrp (MrpI, MrpII, and MrpIII) and peptides of all three elicited bactericidal antibodies against multiple emm types...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168172/comparison-of-immunogenicity-and-safety-of-an-influenza-vaccine-administered-concomitantly-with-a-13-valent-pneumococcal-conjugate-vaccine-or-23-valent-polysaccharide-pneumococcal-vaccine-in-the-elderly
#14
Yu Bin Seo, Won Suk Choi, Jacob Lee, Joon Young Song, Hee Jin Cheong, Woo Joo Kim
PURPOSE: Previous studies have demonstrated the immunogenicity and safety of the co-administration of the trivalent inactivated influenza vaccine (IIV3) with the polysaccharide pneumococcal vaccine (PPV) or pneumococcal conjugate vaccine (PCV). However, there is no direct comparison study that evaluates the immunogenicity and safety of IIV3 given concomitantly with PCV13 or PPV23 in the elderly. MATERIALS AND METHODS: During the 2012-2013 influenza vaccination period, 224 healthy elderly volunteers aged 65 years and older randomly received IIV3 given concomitantly with either PCV13 (PCV13+IIV3) or PPV23 (PPV23+IIV3) in a 1:1 ratio...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168171/psychogenic-illness-following-vaccination-exploratory-study-of-mass-vaccination-against-pandemic-influenza-a-h1n1-in-2009-in-south-korea
#15
Tae Un Yang, Hee Jung Kim, Yeon Kyeong Lee, Young-Joon Park
PURPOSE: Adverse events during mass vaccination campaigns have had a profoundly negative impact on vaccine coverage rates. The objective of the study was to identify the characteristics of reported psychogenic illness cases following mass vaccination that needed further interventions of the national immunization program. MATERIALS AND METHODS: We collected documents that were submitted to the Korea Centers for Disease Control and Prevention for vaccine injury compensation, and analyzed cases of psychogenic illness following pandemic influenza A (H1N1) vaccination in 2009 which were confirmed by the Korean Advisory Committee on Vaccine Injury Compensation...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168170/tetanus-diphtheria-acellular-pertussis-vaccination-for-adults-an-update
#16
REVIEW
Hyo-Jin Lee, Jung-Hyun Choi
Although tetanus and diphtheria have become rare in developed countries, pertussis is still endemic in some developed countries. These are vaccine-preventable diseases and vaccination for adults is important to prevent the outbreak of disease. Strategies for tetanus, diphtheria, and pertussis vaccines vary from country to country. Each country needs to monitor consistently epidemiology of the diseases and changes vaccination policies accordingly. Recent studies showed that tetanus-diphtheria-acellular pertussis vaccine for adults is effective and safe to prevent pertussis disease in infants...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168169/the-development-of-mucosal-vaccines-for-both-mucosal-and-systemic-immune-induction-and-the-roles-played-by-adjuvants
#17
REVIEW
Sae-Hae Kim, Yong-Suk Jang
Vaccination is the most successful immunological practice that improves the quality of human life and health. Vaccine materials include antigens of pathogens and adjuvants potentiating the effectiveness of vaccination. Vaccines are categorized using various criteria, including the vaccination material used and the method of administration. Traditionally, vaccines have been injected via needles. However, given that most pathogens first infect mucosal surfaces, there is increasing interest in the establishment of protective mucosal immunity, achieved by vaccination via mucosal routes...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168168/enterovirus-71-infection-and-vaccines
#18
REVIEW
Eun-Je Yi, Yun-Ju Shin, Jeong-Hwan Kim, Tae-Gyun Kim, Sun-Young Chang
Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising fever, loss of appetite, and a rash with blisters, which do not need specific treatment. However, there are uncommon neurological or cardiac complications such as meningitis and acute flaccid paralysis that can be fatal...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28168167/challenges-in-the-development-of-t-cell-based-universal-influenza-vaccines
#19
EDITORIAL
Jung-Ok Kang, Jun Chang
No abstract text is available yet for this article.
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/27489808/a-bordetella-pertussis-proteoliposome-induces-protection-in-mice-without-affecting-the-immunogenicity-of-diphtheria-and-tetanus-toxoids-in-a-trivalent-formulation
#20
Sonsire Fernández Castillo, Mario Landys Chovel, Niurka Gutiérrez Hernández, Lorena Corcho González, Amaya Blanco, Daily Serrano Hernández, Mildrey Fariñas Medina, Maydelis Álvarez Tito, José Luis Pérez Quiñoy
In this study, a formulation of Bordetella pertussis proteoliposome (PLBp), diphtheria, and tetanus toxoids and alum (DT-PLBp) was evaluated as a trivalent vaccine candidate in BALB/c mice. Vaccine-induced protection was estimated using the intranasal challenge for pertussis and enzyme-linked immunosorbent assay fvto assess serological responses for diphtheria or tetanus. Both, diphtheria-tetanus-whole cell pertussis (DTP) and diphtheria-tetanus vaccines (DT) were used as controls. Animals immunized with DT-PLBp, PLBp alone, and DTP showed total reduction of CFU in lungs 7 days after intranasal challenge...
July 2016: Clinical and Experimental Vaccine Research
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