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Cancer Biology & Medicine

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https://www.readbyqxmd.com/read/29372109/brain-metastasis-in-non-small-cell-lung-cancer-nsclc-patients-with-uncommon-egfr-mutations-a-report-of-seven-cases-and-literature-review
#1
Puchun Er, Tian Zhang, Jing Wang, Qingsong Pang, Ping Wang
Brain metastasis (BM) arising from non-small cell lung cancer (NSCLC) with rare epidermal growth factor receptor (EGFR) mutations is quite rare. The prognosis and therapeutic effects of BM remain enigmatic. To the best of our knowledge, this is the first report to make a separate analysis of BM from NSCLC patients with original uncommon EGFR mutations. We retrospectively reviewed 7 cases of BM arising from 42 cases of uncommon EGFR mutated lung cancer in Tianjin Medical University Cancer Institute and Hospital...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372108/complete-pathologic-response-after-chemoradiotherapy-in-a-patient-with-rectal-squamous-cell-carcinoma-a-case-report
#2
Zaied Sonia, Daldoul Amira, Bhiri Hanene, Ammar Nouha, Khechine Wiem, Toumi Omar, Abbes Ibtissem, Ben Salem Amina, Njima Manel, Mhabrech Houda
Squamous cell carcinoma (SCC) of the rectum is a rare disease. A 59-year-old man presented with SCC of the middle rectum located 10 cm from the anus. The stage of the tumor was revealed to be T3N+M0. The patient received a combined treatment with cisplatin and fluorouracil in concomitance with external radiation therapy. He then underwent an anterior resection of the rectum. The postoperative histopathological findings classified the tumor as ypT0N0 with cancer-free margins and lymph nodes. Treatment of SCC remains very challenging, and the acquisition of more consistent data is needed...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372107/increased-expression-of-yap1-in-prostate-cancer-correlates-with-extraprostatic-extension
#3
Filiz Kisaayak Collak, Ummuhan Demir, Seyma Ozkanli, Esra Kurum, Pinar Engin Zerk
Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in clinical samples of PCa and cell lines. Methods: Fifty-four tumor, adjacent nontumor, and prostate intraepithelial neoplasia (PIN) tissues from patients with PCa after radical prostatectomy were selected from a retrospective cohort and studied using immunohistochemistry (IHC)...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372106/thermogenic-protein-ucp1-and-ucp3-expression-in-non-small-cell-lung-cancer-relation-with-glycolysis-and-anaerobic-metabolism
#4
Alexandra Giatromanolaki, Konstantina Balaska, Dimitra Kalamida, Christos Kakouratos, Efthimios Sivridis, Michael I Koukourakis
Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients with non-small cell lung cancer (NSCLC) treated with surgery. Expression patterns were correlated with histopathological variables, prognosis, and the expression of enzymes/proteins related to cell metabolism. Bronchial epithelium did not express UCP1 or UCP3, while alveolar cells strongly expressed UCP1...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372105/profile-of-the-breast-cancer-susceptibility-marker-rs4245739-identifies-a-role-for-mirnas
#5
Sumadi Lukman Anwar, Wahyu Wulaningsih, Johnathan Watkins
Objective: To determine the influence of the single nucleotide polymorphism (SNP) rs4245739 on the binding and expression of microRNAs and subsequent MDM4 expression and the correlation of these factors with clinical determinants of ER-negative breast cancers. Methods: FindTar and miRanda were used to detect the manner in which potential microRNAs are affected by the SNP rs4245739-flanking sequence. RNA sequencing data for ER-negative breast cancer from The Cancer Genome Atlas (TCGA) were used to compare the expression of miR-184, miR-191, miR-193a, miR-378, and MDM4 in different rs4245739 genotypes...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372104/promoter-methylation-of-wnt-%C3%AE-catenin-signal-inhibitor-tmem88-is-associated-with-unfavorable-prognosis-of-non-small-cell-lung-cancer
#6
Rongna Ma, Nannan Feng, Xiao Yu, Hongyan Lin, Xiaohong Zhang, Oumin Shi, Huan Zhang, Shuo Zhang, Lei Li, Min Zheng, Ming Gao, Herbert Yu, Biyun Qian
Objective: Recent research has indicated that altered promoter methylation of oncogenes and tumor suppressor genes is an important mechanism in lung cancer development and progression. In this study, we investigated the association between promoter methylation of TMEM88, a possible inhibitor of the Wnt/β-Catenin signaling, and the survival of patients with non-small cell lung cancer (NSCLC). Methods: Twelve pairs of tumor and adjacent non-tumor samples were used for microarray analyses of DNA methylation and gene expression...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372103/brain-metastasis-in-advanced-colorectal-cancer-results-from-the-south-australian-metastatic-colorectal-cancer-samcrc-registry
#7
Gonzalo Tapia Rico, Timothy J Price, Christos Karapetis, Cynthia Piantadosi, Rob Padbury, Amitesh Roy, Guy Maddern, James Moore, Scott Carruthers, David Roder, Amanda R Townsend
Objective: Brain metastasis is considered rare in metastatic colorectal cancer (mCRC); thus, surveillance imaging does not routinely include the brain. The reported incidence of brain metastases ranges from 0.6% to 3.2%. Methods: The South Australian mCRC Registry (SAmCRC) was analyzed to assess the number of patients presenting with brain metastasis during their lifetime. Due to small numbers, a descriptive analysis is presented. Results: Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis (1...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372102/camptothecin-based-nanodrug-delivery-systems
#8
Yan Wen, Yingze Wang, Xiaoli Liu, Wei Zhang, Xinhe Xiong, Zhongxiao Han, Xingjie Liang
The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon cancer, liver cancer, and lung cancer. Camptothecin-based drugs inhibit topoisomerase 1 (Topo 1), leading to destruction of DNA, and are currently being used as important chemotherapeutic agents in clinical antitumor treatment. However, the main obstacle associated with cancer therapy is represented by systemic toxicity of conventional anticancer drugs and their low accumulation at the tumor site...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372101/cell-cycle-regulation-and-anticancer-drug-discovery
#9
Jingwen Bai, Yaochen Li, Guojun Zhang
Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent kinase (CDK)-cyclin complexes, checkpoint kinases, and CDK inhibitors. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, several cell cycle inhibitors have emerged as potential therapeutic drugs for the treatment of cancers-both as single-agent therapy and in combination with traditional cytotoxic or molecular targeting agents...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372100/the-ascent-of-immune-checkpoint-inhibitors-is-the-understudy-ready-for-a-leading-role
#10
Amy L Cummings, Edward B Garon
No abstract text is available yet for this article.
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372099/a-race-to-uncover-a-panoramic-view-of-primary-liver-cancer
#11
Ruidong Xue, Jing Li, Fan Bai, Xinwei Wang, Junfang Ji, Yinying Lu
No abstract text is available yet for this article.
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28948061/2016-chinese-expert-consensus-and-guidelines-for-the-diagnosis-and-treatment-of-papillary-thyroid-microcarcinoma
#12
Ming Gao, Minghua Ge, Qinghai Ji, Ruochuan Cheng, Hankui Lu, Haixia Guan, Li Gao, Zhuming Guo, Tao Huang, Xiaoming Huang, Xiaoming Li, Yansong Lin, Qinjiang Liu, Xin Ni, Yi Pan, Jianwu Qin, Zhongyan Shan, Hui Sun, Xudong Wang, Zhengang Xu, Yang Yu, Daiwei Zhao, Naisong Zhang, Sheng Zhang, Ying Zheng, Jingqiang Zhu, Dapeng Li, Xiangqian Zheng, Chinese Association Of Thyroid Oncology Cato Chinese Anti-Cancer Association
No abstract text is available yet for this article.
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884049/potential-predictive-factors-for-pathologic-complete-response-after-the-neoadjuvant-treatment-of-rectal-adenocarcinoma-a-single-center-experience
#13
Feryel Letaief, Meher Nasri, Mouna Ayadi, Khedija Meddeb, Amina Mokrani, Yosra Yahyaoui, Nesrine Chraiet, Henda Raies, Amel Mezlini
OBJECTIVE: : To assess the response rate of patients with rectal adenocarcinoma to neoadjuvant therapy and to identify the predictors of histological regression after neoadjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). METHODS: : This study recruited 64 patients. The patients had resectable cancer of the lower and the middle rectum (T3/T4 and/or N+) without distant metastasis and received neoadjuvant RT or CCRT followed by radical surgery with total mesorectal excision (TME) between January 2006 and December 2011...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884048/expression-levels-of-%C3%AE-catenin-and-galectin-3-in-meningioma-and-their-effect-on-brain-invasion-and-recurrence-a-tissue-microarray-study
#14
Rehab Allah Ahmed, Abdelhadi M Shebl, Hany Onsy Habashy
OBJECTIVE: Meningiomas are neoplasms that arise from the meninges of the central nervous system (CNS). They constitute about 25.6% of CNS tumors diagnosed in Egypt. Some morphological variants of meningiomas display aggressive behavior, leading to brain-invasive growth pattern. Although meningiomas are usually treated by complete surgical excision, the risk of postoperative recurrence remains. Hence, additional biomarkers for predicting aggressive behavior must be discovered. This study aims to explore the clinical and biological relevance of the protein expression levels of β-catenin and galectine-3 in meningioma and to understand the pathobiology of this neoplasm...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884047/bsmi-rs1544410-and-foki-rs2228570-vitamin-d-receptor-polymorphisms-smoking-and-body-mass-index-as-risk-factors-of-cutaneous-malignant-melanoma-in-northeast-italy
#15
Sabina Cauci, Vincenzo Maione, Cinzia Buligan, Martina Linussio, Diego Serraino, Giuseppe Stinco
OBJECTIVE: : To investigate whether vitamin D receptor gene (VDR) BsmI-rs1544410 and FokI-rs2228570 polymorphisms, smoking duration, and body mass index (BMI) are risk factors for cutaneous melanoma, especially metastatic melanoma. METHODS: : We studied 120 cutaneous melanoma cases [68 stage I and II non-metastatic melanoma (NMetM) patients, plus 52 Stage III and IV metastatic melanoma (MetM) patients], and 120 matching healthy controls from northeast Italy. VDR polymorphisms were measured by restriction fragment length polymorphism analysis...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884046/inhibition-of-ikk-nf%C3%AE%C2%BAb-pathway-sensitizes-lung-cancer-cell-lines-to-radiation
#16
Avgi Tsolou, Maria Liousia, Dimitra Kalamida, Stamatia Pouliliou, Alexandra Giatromanolaki, Michael Koukourakis
OBJECTIVE: : Cancer cell radioresistance is a stumbling block in radiation therapy. The activity in the nuclear factor kappa B (NFκB) pathway correlates with anti-apoptotic mechanisms and increased radioresistance. The IKK complex plays a major role in NFκB activation upon numerous signals. In this study, we examined the interaction between ionizing radiation (IR) and different members of the IKK-NFκB pathway, as well as upstream activators, RAF1, ERK, and AKT1. METHODS: : The effect of 4 Gy of IR on the expression of the RAF1-ERK-IKK-NFκB pathway was examined in A549 and H1299 lung cancer cell lines using Western blot analysis and confocal microscopy...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884045/braf-mutation-in-colorectal-carcinomas-with-signet-ring-cell-component
#17
Serap Yalcin, Onder Onguru
OBJECTIVE: : Signet ring cell carcinoma is a rare subtype of colorectal carcinoma (CRC) with an associated BRAFV600E mutation. We investigated frequencies of BRAF mutation in 28 CRCs containing variable signet ring cell component and their relation with clinicopathologic parameters. METHODS: : According to the presence of signet ring cell component, tumors were categorized into groups as follows: 0%-9%, 10%-24%, 25%-49%, and >50%. Genomic DNA was isolated and analyzed for BRAF V600E gene mutation by polymerase chain reaction-restriction fragment length polymorphism...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884044/survival-after-pulmonary-metastasectomy-in-colorectal-cancer-patients-does-a-history-of-resected-liver-metastases-worsen-the-prognosis-a-literature-review
#18
Jon Zabaleta, Borja Aguinagalde, Iker Lopez, Arantza Fernandez-Monge, Jose M Izquierdo, Jose I Emparanza
OBJECTIVE: : To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung metastases. METHODS: : We conducted a review of literature published from 2007 to 2014. The studies were identified by searching PubMed, MEDLINE, and Embase and were supplemented by a manual search of the references listed by the retrieved studies. The following search terms were used: lung metastasectomy, pulmonary metastasectomy, lung metastases, and lung metastasis...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884043/preclinical-and-clinical-applications-of-specific-molecular-imaging-for-her2-positive-breast-cancer
#19
Wei Chen, Xiaofeng Li, Lei Zhu, Jianjing Liu, Wengui Xu, Ping Wang
Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2 (HER2) is associated with high-grade breast tumors, high rates of lymph-node involvement, high risk of recurrence, and high resistance to general chemotherapy. Analysis of HER2 expression is highly important for doctors to identify patients who can benefit from trastuzumab therapy and monitor the response and efficacy of treatment...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28884042/aberrant-control-of-nf-%C3%AE%C2%BAb-in-cancer-permits-transcriptional-and-phenotypic-plasticity-to-curtail-dependence-on-host-tissue-molecular-mode
#20
Spiros A Vlahopoulos
The role of the transcription factor NF-κB in shaping the cancer microenvironment is becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF-κB function, and causes extensive changes in genomic chromatin that ultimately drastically alter cell-specific gene expression. NF-κB regulates the expression of cytokines and adhesion factors that control interactions among adjacent cells. As such, NF-κB fine tunes tissue cellular composition, as well as tissues' interactions with the immune system...
August 2017: Cancer Biology & Medicine
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