journal
https://read.qxmd.com/read/38525901/decreased-ldhb-expression-in-breast-tumor-cells-causes-nk-cell-activation-and-promotes-tumor-progression
#1
JOURNAL ARTICLE
Zhihong Luo, Xiaohua Huang, Xinyi Xu, Kefeng Wei, Yi Zheng, Ke Gong, Wenhua Li
OBJECTIVE: Abnormal metabolism is the underlying reason for breast cancer progression. Decreased lactate dehydrogenase B ( LDHB ) has been detected in breast cancer but the function of LDHB remains unknown. METHODS: Western blot was used to analyze LDHB expression in breast cancer cells. The impact of LDHB on tumor cell migration and invasion was determined using Transwell assays, wound healing assays, and a mouse lung metastasis model. Subcutaneous tumor formation, a natural killer (NK) cell cytotoxicity assay, and flow cytometry evaluated NK cell activation...
March 25, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38445445/efficacy-and-safety-of-anlotinib-combined-with-the-stupp-regimen-in-patients-with-newly-diagnosed-glioblastoma-a-multicenter-single-arm-phase-ii-trial
#2
JOURNAL ARTICLE
Shuzhen Lai, Peijing Li, Xiaohui Liu, Guihong Liu, Tieming Xie, Xing Zhang, Xiaoxuan Wang, Jing Huang, Yiqiang Tang, Zhigang Liu, Guoping Shen, Chaoming Li, Fangxiao Lu, Lei Wang, Fagui Jiang, Caixing Sun, Yuanyuan Chen, Ming Chen
OBJECTIVE: Glioblastomas are highly vascularized malignant tumors. We determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor, anlotinib, for a newly diagnosed glioblastoma. METHODS: This multicenter, single-arm trial (NCT04119674) enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November 2020. Patients underwent treatment with the standard STUPP regimen [fractionated focal irradiation in daily fractions of 1...
March 4, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38425216/blockade-of-cd300a-enhances-the-ability-of-human-nk-cells-to-lyse-hematologic-malignancies
#3
JOURNAL ARTICLE
Shuangcheng Li, Tianci Wang, Xinghui Xiao, Xiaodong Zheng, Haoyu Sun, Rui Sun, Hongdi Ma, Zhigang Tian, Xiaohu Zheng
OBJECTIVE: The human cluster of differentiation (CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer (NK) cells targeting hematologic malignancies (HMs). METHODS: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine (PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings...
February 29, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38425217/influence-of-sex-on-outcomes-of-liver-transplantation-for-hepatocellular-carcinoma-a-multicenter-cohort-study-in-china
#4
JOURNAL ARTICLE
Jian Chen, Zhe Yang, Fengqiang Gao, Zhisheng Zhou, Junli Chen, Di Lu, Kai Wang, Meihua Sui, Zhengxin Wang, Wenzhi Guo, Guoyue Lyu, Haizhi Qi, Jinzhen Cai, Jiayin Yang, Shusen Zheng, Xiao Xu
OBJECTIVE: Sex-specific differences are observed in various liver diseases, but the influence of sex on the outcomes of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains to be determined. This study is the first Chinese nationwide investigation of the role of sex in post-LT outcomes in patients with HCC. METHODS: Data for recipients with HCC registered in the China Liver Transplant Registry between January 2015 and December 2020 were analyzed...
February 28, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172538/emerging-mechanisms-and-implications-of-cgas-sting-signaling-in-cancer-immunotherapy-strategies
#5
REVIEW
Jiawen Zhang, Sihui Yu, Qiao Peng, Ping Wang, Lan Fang
The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment. Within this landscape, the innate immune system, a critical sentinel protecting against tumor incursion, is a key player. The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway has been found to be a linchpin of innate immunity: activation of this signaling pathway orchestrates the production of type I interferon (IFN-α/β), thus fostering the maturation, differentiation, and mobilization of immune effectors in the tumor microenvironment...
January 3, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172499/prognostic-significance-of-grade-of-malignancy-based-on-histopathological-differentiation-and-ki-67-in-pancreatic-ductal-adenocarcinoma
#6
JOURNAL ARTICLE
Yuexiang Liang, Guannan Sheng, Yu Guo, Yiping Zou, Hanhan Guo, Zhifei Li, Shaofei Chang, Quan Man, Song Gao, Jihui Hao
OBJECTIVE: Tumor cell malignancy is indicated by histopathological differentiation and cell proliferation. Ki-67, an indicator of cellular proliferation, has been used for tumor grading and classification in breast cancer and neuroendocrine tumors. However, its prognostic significance in pancreatic ductal adenocarcinoma (PDAC) remains uncertain. METHODS: Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled, and relevant prognostic factors were examined...
January 3, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172555/cervical-cancer-prevention-in-china-where-are-we-now-and-what-s-next
#7
JOURNAL ARTICLE
Huijiao Yan, Qiankun Wang, Youlin Qiao
No abstract text is available yet for this article.
January 2, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172526/current-status-of-early-gastric-cancer-screening-research
#8
JOURNAL ARTICLE
Can Hu, Li Yuan, Xiangdong Cheng
No abstract text is available yet for this article.
January 2, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38172525/cancer-educated-neutrophils-promote-lung-cancer-progression-via-parp-1-alox5-mediated-mmp-9-expression
#9
JOURNAL ARTICLE
Lulu Han, Yuxin Chen, Nan Huang, Xiaowan Zhou, Yanfang Lv, Huizhong Li, Dafei Chai, Junnian Zheng, Gang Wang
OBJECTIVE: Neutrophils are one of the most predominant infiltrating leukocytes in lung cancer tissues and are associated with lung cancer progression. How neutrophils promote lung cancer progression, however, has not been established. METHODS: Kaplan-Meier plotter online analysis and tissue immunohistochemistry were used to determine the relationship between neutrophils and overall survival in lung cancer patients. The effect of neutrophils on lung cancer was determined using the Transwell migration assay, a proliferation assay, and a murine tumor model...
January 2, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38544488/erratum-to-treatment-strategies-for-patients-with-her2-positive-gastric-cancer
#10
Feixue Wang, Yi Ba
No abstract text is available yet for this article.
March 27, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38544483/a-retrospective-analysis-of-mature-t-and-nk-cell-lymphomas
#11
LETTER
Junlei Jia, Xiaohui Wang, Zheng Song, Shen Meng, Yue Fei, Jingwei Yu, Xia Liu, Xue Han, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Wenchen Gong, Bin Meng, Xiubao Ren, Xianhuo Wang, Huilai Zhang
No abstract text is available yet for this article.
March 27, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38544481/reducing-the-global-cancer-burden-with-gastrointestinal-screening-china-s-30-years-practice
#12
EDITORIAL
Lei Yang, Li Feng, Yong Zhu, Ning Wang, Xinpu Lu, Fanghui Gu, Xiaotian Zhang, Jiafu Ji
No abstract text is available yet for this article.
March 27, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38356245/current-and-future-trends-in-whole-genome-sequencing-in-cancer
#13
REVIEW
Yuki Katsuya
No abstract text is available yet for this article.
February 15, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318978/dna-methylation-biomarkers-for-early-detection-of-gastric-and-colorectal-cancers
#14
JOURNAL ARTICLE
Xianchun Gao, Hui Liu, Jun Yu, Yongzhan Nie
No abstract text is available yet for this article.
February 5, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318945/advances-in-atm-atr-wee1-and-chk1-2-inhibitors-in-the-treatment-of-parp-inhibitor-resistant-ovarian-cancer
#15
EDITORIAL
Qin Tang, Xin Wang, Haixia Wang, Lin Zhong, Dongling Zou
No abstract text is available yet for this article.
February 5, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318935/insight-into-the-evolution-of-breast-cancer-driven-by-genetic-alterations
#16
EDITORIAL
Canbin Fang, Xueqi Fan, Wanling Lin, Guojun Zhang
No abstract text is available yet for this article.
February 5, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318930/chemotherapy-free-radiotherapy-combined-with-immune-checkpoint-inhibitors-a-new-regimen-for-locally-advanced-non-small-cell-lung-cancer
#17
REVIEW
Lin Ma, Liufu Deng, Jianfeng Peng, Jinming Yu, Xiangjiao Meng
Maintenance immunotherapy after concurrent chemoradiotherapy remains the standard therapeutic approach in patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC). The efficacy of pembrolizumab without chemotherapy in stage IV NSCLC has incited interest in similar approaches for LA-NSCLC. Several recent investigations involving the synergistic potential of immunotherapy combined with radiotherapy (iRT) have generated encouraging results. This review discusses the existing studies and prospective directions of chemotherapy-free iRT strategies in unresectable LA-NSCLC...
February 5, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318928/current-therapeutic-landscape-and-resistance-mechanisms-to-larotrectinib
#18
JOURNAL ARTICLE
Weiji Xie, Jiaqian Xu, Suying Lu, Yizhuo Zhang
No abstract text is available yet for this article.
February 5, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318925/deep-learning-methods-for-unveiling-large-scale-single-cell-transcriptomes
#19
JOURNAL ARTICLE
Xilin Shen, Xiangchun Li
No abstract text is available yet for this article.
February 5, 2024: Cancer Biology & Medicine
https://read.qxmd.com/read/38318923/neutrophils-in-the-era-of-single-cell-rna-sequencing-functions-and-targeted-therapies-in-cancer
#20
EDITORIAL
Jing Qin, Feng Wei, Xiubao Ren
No abstract text is available yet for this article.
February 5, 2024: Cancer Biology & Medicine
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