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Cancer Biology & Medicine

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https://www.readbyqxmd.com/read/29545973/post-irradiation-pericardial-malignant-mesothelioma-with-deletion-of-p16-a-case-report
#1
Yalda B Naeini, Ramir Arcega, Sharon Hirschowitz, Nagesh Rao, Haodong Xu
Malignant mesotheliomas are rather uncommon neoplasms associated primarily with asbestos exposure; however, they may also arise as second primary malignancies after radiation therapy, with a latency period of 15-25 years. Numerous studies have reported an association between pleural malignant mesothelioma and chest radiation performed for other malignancies; on the other hand, post-irradiation mesotheliomas of the pericardium have been reported in only a few published cases to date, and no homozygous deletion of 9p21 has been described in such cases...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545972/prognostic-significance-of-combined-fibrinogen-concentration-and-neutrophil-to-lymphocyte-ratio-in-patients-with-resectable-non-small-cell-lung-cancer
#2
Wuhao Huang, Shengguang Wang, Hua Zhang, Bin Zhang, Changli Wang
Objective: Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival. In this study, we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio (NLR) in predicting the survival of patients with non-small cell lung cancer (NSCLC). Methods: We retrospectively enrolled 589 patients with NSCLC who underwent surgery. The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators, including the combination of fibrinogen and NLR (F-NLR)...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545971/modified-blumgart-anastomosis-without-pancreatic-duct-to-jejunum-mucosa-anastomosis-for-pancreatoduodenectomy-a-feasible-and-safe-novel-technique
#3
Xiaoqing Wang, Yang Bai, Mangmang Cui, Qingxiang Zhang, Wei Zhang, Feng Fang, Tianqiang Song
Objective: This study proposed a modified Blumgart anastomosis (m-BA) that uses a firm ligation of the main pancreatic duct with a supporting tube to replace the pancreatic duct-to-jejunum mucosa anastomosis, with the aim of simplifying the complicated steps of the conventional BA (c-BA). Thus, we observe if a difference in the risk of postoperative pancreatic fistula (POPF) exists between the two methods. Methods: The m-BA anastomosis method has been used since 2010...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545970/a-new-combined-criterion-to-better-predict-malignant-lesions-in-patients-with-pancreatic-cystic-neoplasms
#4
Chungen Lan, Xin Li, Xiuchao Wang, Jihui Hao, He Ren
Objective: Cystic lesions of the pancreas have been increasingly recognized. Some lesions exhibit benign behavior, while others have unequivocal malignant potential. Thus, accurate identification of malignancy in patients diagnosed with pancreatic cystic neoplasms (PCNs) remains a major challenge. The aim of this study was to define a combined criterion to better predict malignant lesions in patients with PCNs. Methods: We retrospectively analyzed 165 patients who underwent resection of PCNs from October 2011 to May 2017...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545969/parkin-protein-expression-and-its-impact-on-survival-of-patients-with-advanced-colorectal-cancer
#5
Claudia Caroline Veloso da Silva-Camargo, Rosimeri Kuhl Svoboda Baldin, Nayanne Louise Costacurta Polli, Amanda Pereira Agostinho, Marcia Olandosk, Lúcia de Noronha, Vanessa Santos Sotomaior
Objective: Features of colorectal cancer such as natural history, molecular, chromosomal, and epigenetic alterations have been well described. However, there is still a lack of accurate prognostic markers, which is evident by the lower overall survival rates of patients with advanced cancer. Although alterations in parkin protein expression have been described in colorectal cancer, the functional significance of this protein remains unknown. The present study aimed to investigate the involvement of parkin expression in colorectal adenocarcinoma development and progression by evaluating the association between its expression, clinicopathological parameters, and expression of known proteins involved in colorectal cancer...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545968/calcium-channel-%C3%AE-2%C3%AE-1-subunit-as-a-novel-biomarker-for-diagnosis-of-hepatocellular-carcinoma
#6
Sana Amhimmid Badr, Maryan Waheeb Fahmi, Manal Mahmoud Nomir, Mamdouh Mohammad El-Shishtawy
Objective: Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. The identification of new simple, inexpensive and highly accurate markers for HCC diagnosis and screening is needed. This case-control study evaluates the role of annexin A2 and voltage-gated calcium channels α2δ1 subunit as serum biomarkers for HCC diagnosis. Methods: The study comprised three groups: group 1, 50 patients with an initial diagnosis of HCC associated with chronic hepatitis C virus infection; group 2, 25 patients diagnosed with chronic hepatitis C virus infection and cirrhosis without any evidence of HCC; and group 3, 15 healthy controls...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545967/egfr-tyrosine-kinase-inhibitor-hs-10182-increases-radiation-sensitivity-in-non-small-cell-lung-cancers-with-egfr-t790m-mutation
#7
Yang Chen, Youyou Wang, Lujun Zhao, Ping Wang, Jifeng Sun, Rudi Bao, Chenghai Li, Ningbo Liu
Objective: To investigate the potential of HS-10182, a second-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), as a radiosensitizer in non-small cell lung cancer (NSCLC). Methods: Two cell lines of NSCLCs, A549 that possesses wild-type (WT) EGFRs and H1975 that possesses EGFR L858R/T790M double mutations, were treated with HS-10182 at various concentrations, and cell viabilities were determined using the MTS assay. The cells were tested by clonogenic survival assays to identify the radiosensitivity of both groups...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545966/silencing-of-syndecan-binding-protein-enhances-the-inhibitory-effect-of-tamoxifen-and-increases-cellular-sensitivity-to-estrogen
#8
Jun Zhang, Xiaolong Qian, Fangfang Liu, Xiaojing Guo, Feng Gu, Li Fu
Objective: Tamoxifen is used as a complementary treatment for estrogen receptor (ER)-positive breast cancer (BCa), but many patients developed resistance. The aim of this study was to examine the role of syndecan-binding protein (SDCBP) silencing in ER-positive BCa cells. Methods: In MCF-7/T47D cells, the effects of SDCBP silence/overexpression on cell proliferation and estrogenic response were examined. Cell proliferation was examined using the MTT assay and cell cycle regulators were examined by Western blot...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545965/dual-specificity-phosphatase-6-dusp6-a-review-of-its-molecular-characteristics-and-clinical-relevance-in-cancer
#9
Muhammad Khairi Ahmad, Nur Ainina Abdollah, Nurul Husna Shafie, Narazah Mohd Yusof, Siti Razila Abdul Razak
Mitogen-activated protein kinases (MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6 (DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545964/biology-staging-and-treatment-of-breast-cancer-during-pregnancy-reassessing-the-evidences
#10
Fedro Alessandro Peccatori, Matteo Lambertini, Giovanna Scarfone, Lino Del Pup, Giovanni Codacci-Pisanelli
Breast cancer is one of the most frequently diagnosed malignancies during pregnancy. Here, we review the management of women with breast cancer during pregnancy (BCP), focusing on biology, diagnosis and staging, local and systemic treatments, obstetric care and long-term follow-up of children with prenatal exposure to anticancer treatments.
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29545963/the-evolution-of-epstein-barr-virus-detection-in-nasopharyngeal-carcinoma
#11
You Quan Li, Ni Sann Khin, Melvin L K Chua
No abstract text is available yet for this article.
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372109/brain-metastasis-in-non-small-cell-lung-cancer-nsclc-patients-with-uncommon-egfr-mutations-a-report-of-seven-cases-and-literature-review
#12
Puchun Er, Tian Zhang, Jing Wang, Qingsong Pang, Ping Wang
Brain metastasis (BM) arising from non-small cell lung cancer (NSCLC) with rare epidermal growth factor receptor (EGFR) mutations is quite rare. The prognosis and therapeutic effects of BM remain enigmatic. To the best of our knowledge, this is the first report to make a separate analysis of BM from NSCLC patients with original uncommon EGFR mutations. We retrospectively reviewed 7 cases of BM arising from 42 cases of uncommon EGFR mutated lung cancer in Tianjin Medical University Cancer Institute and Hospital...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372108/complete-pathologic-response-after-chemoradiotherapy-in-a-patient-with-rectal-squamous-cell-carcinoma-a-case-report
#13
Zaied Sonia, Daldoul Amira, Bhiri Hanene, Ammar Nouha, Khechine Wiem, Toumi Omar, Abbes Ibtissem, Ben Salem Amina, Njima Manel, Mhabrech Houda
Squamous cell carcinoma (SCC) of the rectum is a rare disease. A 59-year-old man presented with SCC of the middle rectum located 10 cm from the anus. The stage of the tumor was revealed to be T3N+M0. The patient received a combined treatment with cisplatin and fluorouracil in concomitance with external radiation therapy. He then underwent an anterior resection of the rectum. The postoperative histopathological findings classified the tumor as ypT0N0 with cancer-free margins and lymph nodes. Treatment of SCC remains very challenging, and the acquisition of more consistent data is needed...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372107/increased-expression-of-yap1-in-prostate-cancer-correlates-with-extraprostatic-extension
#14
Filiz Kisaayak Collak, Ummuhan Demir, Seyma Ozkanli, Esra Kurum, Pinar Engin Zerk
Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in clinical samples of PCa and cell lines. Methods: Fifty-four tumor, adjacent nontumor, and prostate intraepithelial neoplasia (PIN) tissues from patients with PCa after radical prostatectomy were selected from a retrospective cohort and studied using immunohistochemistry (IHC)...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372106/thermogenic-protein-ucp1-and-ucp3-expression-in-non-small-cell-lung-cancer-relation-with-glycolysis-and-anaerobic-metabolism
#15
Alexandra Giatromanolaki, Konstantina Balaska, Dimitra Kalamida, Christos Kakouratos, Efthimios Sivridis, Michael I Koukourakis
Uncoupling protein 1 (UCP1) is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production. Using immunohistochemistry, we investigated the expression of UCP1 and UCP3 in a series of 98 patients with non-small cell lung cancer (NSCLC) treated with surgery. Expression patterns were correlated with histopathological variables, prognosis, and the expression of enzymes/proteins related to cell metabolism. Bronchial epithelium did not express UCP1 or UCP3, while alveolar cells strongly expressed UCP1...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372105/profile-of-the-breast-cancer-susceptibility-marker-rs4245739-identifies-a-role-for-mirnas
#16
Sumadi Lukman Anwar, Wahyu Wulaningsih, Johnathan Watkins
Objective: To determine the influence of the single nucleotide polymorphism (SNP) rs4245739 on the binding and expression of microRNAs and subsequent MDM4 expression and the correlation of these factors with clinical determinants of ER-negative breast cancers. Methods: FindTar and miRanda were used to detect the manner in which potential microRNAs are affected by the SNP rs4245739-flanking sequence. RNA sequencing data for ER-negative breast cancer from The Cancer Genome Atlas (TCGA) were used to compare the expression of miR-184, miR-191, miR-193a, miR-378, and MDM4 in different rs4245739 genotypes...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372104/promoter-methylation-of-wnt-%C3%AE-catenin-signal-inhibitor-tmem88-is-associated-with-unfavorable-prognosis-of-non-small-cell-lung-cancer
#17
Rongna Ma, Nannan Feng, Xiao Yu, Hongyan Lin, Xiaohong Zhang, Oumin Shi, Huan Zhang, Shuo Zhang, Lei Li, Min Zheng, Ming Gao, Herbert Yu, Biyun Qian
Objective : Recent research has indicated that altered promoter methylation of oncogenes and tumor suppressor genes is an important mechanism in lung cancer development and progression. In this study, we investigated the association between promoter methylation of TMEM88 , a possible inhibitor of the Wnt/β-Catenin signaling, and the survival of patients with non-small cell lung cancer (NSCLC). Methods : Twelve pairs of tumor and adjacent non-tumor samples were used for microarray analyses of DNA methylation and gene expression...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372103/brain-metastasis-in-advanced-colorectal-cancer-results-from-the-south-australian-metastatic-colorectal-cancer-samcrc-registry
#18
Gonzalo Tapia Rico, Timothy J Price, Christos Karapetis, Cynthia Piantadosi, Rob Padbury, Amitesh Roy, Guy Maddern, James Moore, Scott Carruthers, David Roder, Amanda R Townsend
Objective: Brain metastasis is considered rare in metastatic colorectal cancer (mCRC); thus, surveillance imaging does not routinely include the brain. The reported incidence of brain metastases ranges from 0.6% to 3.2%. Methods: The South Australian mCRC Registry (SAmCRC) was analyzed to assess the number of patients presenting with brain metastasis during their lifetime. Due to small numbers, a descriptive analysis is presented. Results: Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis (1...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372102/camptothecin-based-nanodrug-delivery-systems
#19
Yan Wen, Yingze Wang, Xiaoli Liu, Wei Zhang, Xinhe Xiong, Zhongxiao Han, Xingjie Liang
The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon cancer, liver cancer, and lung cancer. Camptothecin-based drugs inhibit topoisomerase 1 (Topo 1), leading to destruction of DNA, and are currently being used as important chemotherapeutic agents in clinical antitumor treatment. However, the main obstacle associated with cancer therapy is represented by systemic toxicity of conventional anticancer drugs and their low accumulation at the tumor site...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29372101/cell-cycle-regulation-and-anticancer-drug-discovery
#20
Jingwen Bai, Yaochen Li, Guojun Zhang
Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent kinase (CDK)-cyclin complexes, checkpoint kinases, and CDK inhibitors. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, several cell cycle inhibitors have emerged as potential therapeutic drugs for the treatment of cancers-both as single-agent therapy and in combination with traditional cytotoxic or molecular targeting agents...
November 2017: Cancer Biology & Medicine
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