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Cancer Biology & Medicine

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https://www.readbyqxmd.com/read/28154784/work-up-and-management-of-a-high-risk-patient-with-primary-central-nervous-system-lymphoma
#1
Pervin A Zeynalova, Gayane S Tumyan, Mikhail B Dolgushin, Mobil I Akhmedov
Primary central nervous system lymphoma (PCNSL) is a rare disorder that, in 95% of cases, represents diffuse large B-cell lymphoma. As such, making an accurate diagnosis is important. At present, stereotactic-guided biopsy is a recognized method of choice for tissue analysis. However, the diagnostic work-up for high-risk patients is determined by their performance status. Here, we report a case of PCNSL in a high-risk patient, for whom diagnosis was established by cerebrospinal fluid cytology and flow cytometry, which significantly shortened a diagnostic work-up period and allowed for the immediate treatment of the patient...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154783/leptin-influences-estrogen-metabolism-and-increases-dna-adduct-formation-in-breast-cancer-cells
#2
Samia Shouman, Mohamed Wagih, Marwa Kamel
OBJECTIVE: The elevated incidence of obesity has been paralleled with higher risks of breast cancer. High adiposity increases leptin secretion from adipose tissue, which in turn increases cancer cell proliferation. The interplay between leptin and estrogen is one of the mechanisms through which leptin influences breast carcinogenesis. An unbalanced estrogen metabolism increases the formations of catechol estrogen quinones, DNA adducts, and cancer mutations. This study aims to investigate the effect of leptin on some estrogen metabolic enzymes and DNA adduction in breast cancer cells...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154782/ki-67-as-a-prognostic-marker-according-to-breast-cancer-molecular-subtype
#3
Nahed A Soliman, Shaimaa M Yussif
OBJECTIVE: Ki-67 plays an important function in cell division, but its exact role is still unknown. Moreover, few works regarding its overall function were published. The present study evaluated the clinical significance of Ki-67 index as a prognostic marker and predictor of recurrence in different molecular subtypes of breast cancer. The relationship of Ki-67 index with different clinicopathological factors was also analyzed. METHODS: Ki-67 index was measured in 107 cases of primary breast cancer from 2010-2012...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154781/properties-and-feasibility-of-using-cancer-stem-cells-in-clinical-cancer-treatment
#4
Xiao-Mei Gao, Rui Zhang, Qiong-Zhu Dong, Lun-Xiu Qin
Cancer treatment failure, drug resistance, or metastatic recurrence are thought to be caused mainly by the existence of a very small number of cancer stem cells (CSCs). The characteristics of this subgroup of cells include self-renewal, tumorigenesis, multiple differentiation and high invasiveness, metastasis, and drug resistance potential. Many studies have demonstrated that CSCs play important roles in tumor growth, spread and metastatic relapse after treatment, and are closely related to the prognosis of patients...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154780/human-endogenous-retroviruses-and-cancer
#5
María Gonzalez-Cao, Paola Iduma, Niki Karachaliou, Mariacarmela Santarpia, Julià Blanco, Rafael Rosell
Human endogenous retroviruses (HERVs) are retroviruses that infected human genome millions of years ago and have persisted throughout human evolution. About 8% of our genome is composed of HERVs, most of which are nonfunctional because of epigenetic control or deactivating mutations. However, a correlation between HERVs and human cancer has been described and many tumors, such as melanoma, breast cancer, germ cell tumors, renal cancer or ovarian cancer, express HERV proteins, mainly HERV-K (HML6) and HERV-K (HML2)...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154779/molecular-landscape-in-acute-myeloid-leukemia-where-do-we-stand-in-2016
#6
Karam Al-Issa, Aziz Nazha
Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alterations that impact overall survival. Despite all these advancement, several challenges remain in translating this information into effective therapy. Herein we will review the molecular landscape of AML and discuss the impact of the most common somatic mutations on disease biology and outcome...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154778/surgical-treatment-of-intrahepatic-cholangiocarcinoma-a-retrospective-study-of-104-cases
#7
Xiao-Dong Xun, Qiang Li
OBJECTIVE: To explore the clinicopathological features, surgical treatment techniques, and prognostic risk factors of intrahepatic cholangiocarcinoma (ICC). METHODS: A total of 104 ICC cases were collected from January 2008 to December 2013 at Tianjin Medical University Cancer Institute and Hospital and divided into the hepatic hilum lymphadenectomy (HLL, 21 cases), extended hepatic hilum lymphadenectomy (EHLL, 12 cases), and non-lymphadenectomy (NL, 71 cases) groups...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154777/bcl-2-expression-is-a-poor-predictor-for-hepatocellular-carcinoma-prognosis-of-andropause-age-patients
#8
Xiao-Fei Zhang, Xin Yang, Hu-Liang Jia, Wen-Wei Zhu, Lu Lu, Wei Shi, Hao Zhang, Jin-Hong Chen, Yi-Feng Tao, Zheng-Xin Wang, Jun Yang, Lian-Xin Wang, Ming Lu, Yan Zheng, Jing Zhao, Qiong-Zhu Dong, Lun-Xiu Qin
OBJECTIVE: The expression of B-cell lymphoma 2 (Bcl-2) seems to be influenced by the endocrine environment. Numerous reports demonstrate the diverse expression of Bcl-2 family members under sex steroid regulation. With the exception of estrogen-related tumors, androgen-related tumors have shown their characteristics in Bcl-2 expression. In this study, the status of Bcl-2 expression in male hepatocellular carcinoma (HCC) patients was examined to verify the high incidence of HCC in males...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154776/portal-vein-tumor-thrombus-is-a-bottleneck-in-the-treatment-of-hepatocellular-carcinoma
#9
Ju-Xian Sun, Jie Shi, Nan Li, Wei-Xing Guo, Meng-Chao Wu, Wan-Yee Lau, Shu-Qun Cheng
The effect of portal vein tumor thrombus (PVTT) on the prognosis of patients with hepatocellular carcinoma has become clear over the past several decades. However, identifying the mechanisms and performing the diagnosis and treatment of PVTT remain challenging. Therefore, this study aimed to summarize the progress in these areas. A computerized literature search in Medline and EMBASE was performed with the following combinations of search terms: "hepatocellular carcinoma" AND "portal vein tumor thrombus." Although several signal transduction or molecular pathways related to PVTT have been identified, the exact mechanisms of PVTT are still largely unknown...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154775/three-dimensional-printing-review-of-application-in-medicine-and-hepatic-surgery
#10
Rui Yao, Gang Xu, Shuang-Shuang Mao, Hua-Yu Yang, Xin-Ting Sang, Wei Sun, Yi-Lei Mao
Three-dimensional (3D) printing (3DP) is a rapid prototyping technology that has gained increasing recognition in many different fields. Inherent accuracy and low-cost property enable applicability of 3DP in many areas, such as manufacturing, aerospace, medical, and industrial design. Recently, 3DP has gained considerable attention in the medical field. The image data can be quickly turned into physical objects by using 3DP technology. These objects are being used across a variety of surgical specialties. The shortage of cadaver specimens is a major problem in medical education...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154774/portal-vein-embolization-for-induction-of-selective-hepatic-hypertrophy-prior-to-major-hepatectomy-rationale-techniques-outcomes-and-future-directions
#11
David Li, David C Madoff
The ability to modulate the future liver remnant (FLR) is a key component of modern oncologic hepatobiliary surgery practice and has extended surgical candidacy for patients who may have been previously thought unable to survive liver resection. Multiple techniques have been developed to augment the FLR including portal vein embolization (PVE), associating liver partition and portal vein ligation (ALPPS), and the recently reported transhepatic liver venous deprivation (LVD). PVE is a well-established means to improve the safety of liver resection by redirecting blood flow to the FLR in an effort to selectively hypertrophy and ultimately improve functional reserve of the FLR...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154773/role-of-micrornas-in-inflammation-associated-liver-cancer
#12
Lin Huan, Lin-Hui Liang, Xiang-Huo He
Liver cancer, primarily hepatocellular carcinoma (HCC), is a major cause of cancer-related death worldwide. HCC is a suitable model of inflammation-induced cancer because more than 90% of HCC cases are caused by liver damage and chronic inflammation. Several inflammatory response pathways, such as NF-κB and JAK/STAT3 signaling pathways, play roles in the crosstalk between inflammation and HCC. MicroRNAs (miRNAs) are evolutionarily conserved, short endogenous, non-coding single-stranded RNAs that are involved in various biological and pathological processes by regulating gene expression and protein translation...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154772/liver-cancer-challenge-and-prospect
#13
Qiang Li
No abstract text is available yet for this article.
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807508/occurrence-of-lymphoma-in-non-gonadal-organ-during-pregnancy-a-report-on-four-cases-and-literature-review
#14
Da-Lin Gao, Qian-Qian Fu, Tian-Tian Zhang, Lin Sun, Yi Pan, Qiong-Li Zhai
Lymphoma rarely occurs during pregnancy, making this condition difficult to define. Lymphomas that occur in reproductive organs during pregnancy exhibit unique clinical characteristics. Among the limited cases, non-Hodgkin's lymphoma (NHL) shows a considerably higher incidence rate than Hodgkin's lymphoma (HL); NHL also displays clinical characteristics, such as high aggressiveness, advanced stage, and poor outcome. This study reports on four cases of lymphomas in non-gonadal organs (HL, n=2; NHL, n=2) during pregnancy...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807507/sarcoidosis-imitating-breast-cancer-metastasis-a-case-report-and-literature-review
#15
Teimuraz Kochoyan, Mobil Akhmedov, Alexander Shabanov, Ilya Terekhov
Sarcoidosis is a benign systematic granulomatous disorder of unknown etiology and is associated with various malignancies. However, granulomatous and metastatic lymph node lesions are difficult to distinguish even when using precise and modern diagnostic methods, such as positron emission tomography. Thus, histological verification is the only method that can be used to accurately describe the nature of this disease. In this article, we report a case of non-luminal HER-2/neu-positive breast cancer in a patient without history of sarcoidosis and suspected to have metastatic disease...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807506/primary-peritoneal-carcinoma-metastasizing-to-breast-a-single-case-report-and-literature-review-from-clinic-to-biology
#16
Ji-Yuan Sun, Wondwossen Gebre, Yi-Min Dong, Xiao Shaun, Rachel Robbins, Alida Podrumar
Primary peritoneal carcinoma (PPC) is a type of rare malignant epithelial tumor. Metastasis from PPC to breast has been rarely reported. PPC originates de novo from the peritoneal tissues rather than invasion or metastasis from adjacent or remote organs. PPCs have been implicated in many cases of carcinomas of unknown primary origin. It is similar to ovarian cancer (OvCa), because it shares the same common embryonic origin, the coelomic epithelium (mesodermal origin). The mechanism of oncogenesis remains elusive...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807505/implantable-port-thrombosis-in-cancer-patients-a-monocentric-experience
#17
Manel Dridi, Nesrine Mejri, Soumaya Labidi, Mehdi Afrit, Houda El Benna, Khaoula Ben Miled, Hamouda Boussen
OBJECTIVE: Implantable port thrombosis (IPT) in cancer patients is a relatively rare but severe complication. Several factors are reportedly associated with the occurrence of thrombosis. We aimed to describe the prevalence and the anatomoclinical features of IPT observed in cancer patients who were treated in a medical oncology department in Tunisia. METHODS: A total of 600 cancer patients who had port implantation from January 2013 to December 2015 were retrospectively identified...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807504/the-role-of-radiotherapy-in-the-management-of-localized-soft-tissue-sarcomas
#18
Siaw Sze Tiong, Colleen Dickie, Rick L Haas, Brian O'Sullivan
The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807503/clinical-management-of-myelodysplastic-syndrome-myeloproliferative-neoplasm-overlap-syndromes
#19
Joseph A Clara, David A Sallman, Eric Padron
The myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are a unique group of hematologic malignancies characterized by concomitant myelodysplastic and myeloproliferative features. According to the 2008 WHO classification, the category includes atypical chronic myeloid leukemia (aCML), chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), MDS/MPN-unclassifiable (MDS/MPN-U), and the provisional entity refractory anemia with ring sideroblasts and thrombocytosis (RARS-T). Although diagnosis currently remains based on clinicopathologic features, the incorporation of next-generation platforms has allowed for the recent molecular characterization of these diseases which has revealed unique and complex mutational profiles that support their distinct biology and is anticipated to soon play an integral role in diagnosis, prognostication, and treatment...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807502/near-infrared-dye-loaded-magnetic-nanoparticles-as-photoacoustic-contrast-agent-for-enhanced-tumor-imaging
#20
Chuang Gao, Zi-Jian Deng, Dong Peng, Yu-Shen Jin, Yan Ma, Yan-Yan Li, Yu-Kun Zhu, Jian-Zhong Xi, Jie Tian, Zhi-Fei Dai, Chang-Hui Li, Xiao-Long Liang
Objective: Photoacoustic (PA) tomography (PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human body. Methods: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[methoxy (polyethylene glycol)] (DSPE-PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles (NPs) loaded with indocyanine green (ICG)...
September 2016: Cancer Biology & Medicine
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