Ushashi Dadwal, Carolyne Falank, Heather Fairfield, Sarah Linehan, Clifford J Rosen, David L Kaplan, Julie Sterling, Michaela R Reagan
Cancers that metastasize or grow in the bone marrow are typically considered incurable and cause extensive damage to the bone and bone marrow. The bone is a complex, dynamic, three-dimensional (3D) environment composed of a plethora of cells that may contribute to, or constrain, the growth of tumor cells and development of bone disease. The development of safe and effective drugs is currently hampered by pre-clinical two-dimensional (2D) models whose poor predictive power does not accurately predict the success or failure of therapeutics...
2016: BoneKEy Reports