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Bone & Joint Research

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https://www.readbyqxmd.com/read/27908864/identification-of-candidate-genes-in-osteoporosis-by-integrated-microarray-analysis
#1
J J Li, B Q Wang, Q Fei, Y Yang, D Li
OBJECTIVES: In order to screen the altered gene expression profile in peripheral blood mononuclear cells of patients with osteoporosis, we performed an integrated analysis of the online microarray studies of osteoporosis. METHODS: We searched the Gene Expression Omnibus (GEO) database for microarray studies of peripheral blood mononuclear cells in patients with osteoporosis. Subsequently, we integrated gene expression data sets from multiple microarray studies to obtain differentially expressed genes (DEGs) between patients with osteoporosis and normal controls...
December 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27903506/is-the-hip-capsule-thicker-in-diseased-hips
#2
K S Rakhra, A A Bonura, R Nairn, M E Schweitzer, N M Kolanko, P E Beaule
OBJECTIVES: The purpose of this study was to compare the thickness of the hip capsule in patients with surgical hip disease, either with cam-femoroacetabular impingement (FAI) or non-FAI hip pathology, with that of asymptomatic control hips. METHODS: A total of 56 hips in 55 patients underwent a 3Tesla MRI of the hip. These included 40 patients with 41 hips with arthroscopically proven hip disease (16 with cam-FAI; nine men, seven women; mean age 39 years, 22 to 58) and 25 with non-FAI chondrolabral pathology (four men, 21 women; mean age 40 years, 18 to 63) as well as 15 asymptomatic volunteers, whose hips served as controls (ten men, five women; mean age 62 years, 33 to 77)...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27881441/evaluation-of-the-histological-and-mechanical-features-of-tendon-healing-in-a-rabbit-model-with-the-use-of-second-harmonic-generation-imaging-and-tensile-testing
#3
E Hase, K Sato, D Yonekura, T Minamikawa, M Takahashi, T Yasui
OBJECTIVES: This study aimed to evaluate the histological and mechanical features of tendon healing in a rabbit model with second-harmonic-generation (SHG) imaging and tensile testing. MATERIALS AND METHODS: A total of eight male Japanese white rabbits were used for this study. The flexor digitorum tendons in their right leg were sharply transected, and then were repaired by intratendinous stitching. At four weeks post-operatively, the rabbits were killed and the flexor digitorum tendons in both right and left legs were excised and used as specimens for tendon healing (n = 8) and control (n = 8), respectively...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27881440/culturing-bone-marrow-cells-with-dexamethasone-and-ascorbic-acid-improves-osteogenic-cell-sheet-structure
#4
M Akahane, T Shimizu, T Kira, T Onishi, Y Uchihara, T Imamura, Y Tanaka
OBJECTIVES: To assess the structure and extracellular matrix molecule expression of osteogenic cell sheets created via culture in medium with both dexamethasone (Dex) and ascorbic acid phosphate (AscP) compared either Dex or AscP alone. METHODS: Osteogenic cell sheets were prepared by culturing rat bone marrow stromal cells in a minimal essential medium (MEM), MEM with AscP, MEM with Dex, and MEM with Dex and AscP (Dex/AscP). The cell number and messenger (m)RNA expression were assessed in vitro, and the appearance of the cell sheets was observed after mechanical retrieval using a scraper...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27881439/optimisation-of-high-quality-total-ribonucleic-acid-isolation-from-cartilaginous-tissues-for-real-time-polymerase-chain-reaction-analysis
#5
M Peeters, C L Huang, L A Vonk, Z F Lu, R A Bank, M N Helder, B Zandieh Doulabi
OBJECTIVES: Studies which consider the molecular mechanisms of degeneration and regeneration of cartilaginous tissues are seriously hampered by problematic ribonucleic acid (RNA) isolations due to low cell density and the dense, proteoglycan-rich extracellular matrix of cartilage. Proteoglycans tend to co-purify with RNA, they can absorb the full spectrum of UV light and they are potent inhibitors of polymerase chain reaction (PCR). Therefore, the objective of the present study is to compare and optimise different homogenisation methods and RNA isolation kits for an array of cartilaginous tissues...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27831489/increased-sagittal-vertical-axis-is-associated-with-less-effective-control-of-acute-pain-following-vertebroplasty
#6
Y-C Kim, D H Bok, H-G Chang, S W Kim, M S Park, J K Oh, J Kim, T-H Kim
OBJECTIVES: Although vertebroplasty is very effective for relieving acute pain from an osteoporotic vertebral compression fracture, not all patients who undergo vertebroplasty receive the same degree of benefit from the procedure. In order to identify the ideal candidate for vertebroplasty, pre-operative prognostic demographic or clinico-radiological factors need to be identified. The objective of this study was to identify the pre-operative prognostic factors related to the effect of vertebroplasty on acute pain control using a cohort of surgically and non-surgically managed patients...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27827803/is-calcaneal-broadband-ultrasound-attenuation-a-valid-index-of-dual-energy-x-ray-absorptiometry-derived-bone-mass-in-children
#7
B K Weeks, R Hirsch, R C Nogueira, B R Beck
OBJECTIVES: The aim of the current study was to assess whether calcaneal broadband ultrasound attenuation (BUA) can predict whole body and regional dual-energy x-ray absorptiometry (DXA)-derived bone mass in healthy, Australian children and adolescents at different stages of maturity. METHODS: A total of 389 boys and girls across a wide age range (four to 18 years) volunteered to participate. The estimated age of peak height velocity (APHV) was used to classify children into pre-, peri-, and post-APHV groups...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27811144/the-damping-effect-of-cement-as-a-potential-mitigation-factor-of-squeaking-in-ceramic-on-ceramic-total-hip-arthroplasty
#8
F J Burgo, D E Mengelle, A Ozols, C Fernandez, C M Autorino
OBJECTIVES: Studies reporting specifically on squeaking in total hip arthroplasty have focused on cementless, and not on hybrid, fixation. We hypothesised that the cement mantle of the femur might have a damping effect on the sound transmitted through the metal stem. The objective of this study was to test the effect of cement on sound propagation along different stem designs and under different fixation conditions. METHODS: An in vitro model for sound detection, composed of a mechanical suspension structure and a sound-registering electronic assembly, was designed...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27799147/silencing-of-microrna-138-5p-promotes-il-1%C3%AE-induced-cartilage-degradation-in-human-chondrocytes-by-targeting-foxc1-mir-138-promotes-cartilage-degradation
#9
Y Yuan, G Q Zhang, W Chai, M Ni, C Xu, J Y Chen
OBJECTIVES: Osteoarthritis (OA) is characterised by articular cartilage degradation. MicroRNAs (miRNAs) have been identified in the development of OA. The purpose of our study was to explore the functional role and underlying mechanism of miR-138-5p in interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM) degradation of OA cartilage. MATERIALS AND METHODS: Human articular cartilage was obtained from patients with and without OA, and chondrocytes were isolated and stimulated by IL-1β...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27784670/equipoise-and-the-technology-curve-relevance-in-the-design-of-surgical-trials
#10
EDITORIAL
A H R W Simpson, I R Murray, A D Duckworth
No abstract text is available yet for this article.
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27784669/the-multifactorial-aetiology-of-fracture-nonunion-and-the-importance-of-searching-for-latent-infection
#11
L Mills, J Tsang, G Hopper, G Keenan, A H R W Simpson
OBJECTIVES: A successful outcome following treatment of nonunion requires the correct identification of all of the underlying cause(s) and addressing them appropriately. The aim of this study was to assess the distribution and frequency of causative factors in a consecutive cohort of nonunion patients in order to optimise the management strategy for individual patients presenting with nonunion. METHODS: Causes of the nonunion were divided into four categories: mechanical; infection; dead bone with a gap; and host...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27784668/muscle-as-an-osteoinductive-niche-for-local-bone-formation-with-the-use-of-a-biphasic-calcium-sulphate-hydroxyapatite-biomaterial
#12
D B Raina, A Gupta, M M Petersen, W Hettwer, M McNally, M Tägil, M-H Zheng, A Kumar, L Lidgren
OBJECTIVES: We have observed clinical cases where bone is formed in the overlaying muscle covering surgically created bone defects treated with a hydroxyapatite/calcium sulphate biomaterial. Our objective was to investigate the osteoinductive potential of the biomaterial and to determine if growth factors secreted from local bone cells induce osteoblastic differentiation of muscle cells. MATERIALS AND METHODS: We seeded mouse skeletal muscle cells C2C12 on the hydroxyapatite/calcium sulphate biomaterial and the phenotype of the cells was analysed...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27769958/age-related-effects-on-osteoclastic-activities-after-orthodontic-tooth-movement
#13
X Li, M Li, J Lu, Y Hu, L Cui, D Zhang, Y Yang
OBJECTIVES: To elucidate the effects of age on the expression levels of the receptor activator of the nuclear factor-κB ligand (RANKL) and osteoclasts in the periodontal ligament during orthodontic mechanical loading and post-orthodontic retention. MATERIALS AND METHODS: The study included 20 male Sprague-Dawley rats, ten in the young group (aged four to five weeks) and ten in the adult group (aged 18 to 20 weeks). In each rat, the upper-left first molar was subjected to a seven-day orthodontic force loading followed by a seven-day retention period...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27765735/a-process-evaluation-of-the-white-two-trial-comparing-total-hip-artroplasty-with-and-without-dual-mobility-component-in-the-treatment-of-displaced-intracapsular-fractures-of-the-proximal-femur-can-a-trial-investigating-total-hip-arthroplasty-for-hip-fracture
#14
C Huxley, J Achten, M L Costa, F Griffiths, X L Griffin
OBJECTIVES: The annual incidence of hip fracture is 620 000 in the European Union. The cost of this clinical problem has been estimated at 1.75 million disability-adjusted life years lost, equating to 1.4% of the total healthcare burden in established market economies. Recent guidance from The National Institute for Health and Clinical Excellence (NICE) states that research into the clinical and cost effectiveness of total hip arthroplasty (THA) as a treatment for hip fracture is a priority...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27760727/to-operate-or-not-to-operate-that-is-the-question-the-proximal-humerus-fracture
#15
M Ghert, M McKee
No abstract text is available yet for this article.
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27756739/defining-the-fracture-population-in-a-pragmatic-multicentre-randomised-controlled-trial-profher-and-the-neer-classification-of-proximal-humeral-fractures
#16
H H G Handoll, S D Brealey, L Jefferson, A Keding, A J Brooksbank, A J Johnstone, J J Candal-Couto, A Rangan
OBJECTIVES: Accurate characterisation of fractures is essential in fracture management trials. However, this is often hampered by poor inter-observer agreement. This article describes the practicalities of defining the fracture population, based on the Neer classification, within a pragmatic multicentre randomised controlled trial in which surgical treatment was compared with non-surgical treatment in adults with displaced fractures of the proximal humerus involving the surgical neck...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27756738/trials-based-on-specific-fracture-configuration-and-surgical-procedures-likely-to-be-more-relevant-for-decision-making-in-the-management-of-fractures-of-the-proximal-humerus-findings-of-a-meta-analysis
#17
S Sabharwal, N K Patel, D Griffiths, T Athanasiou, C M Gupte, P Reilly
OBJECTIVES: The objective of this study was to perform a meta-analysis of all randomised controlled trials (RCTs) comparing surgical and non-surgical management of fractures of the proximal humerus, and to determine whether further analyses based on complexity of fracture, or the type of surgical intervention, produced disparate findings on patient outcomes. METHODS: A systematic review of the literature was performed identifying all RCTs that compared surgical and non-surgical management of fractures of the proximal humerus...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27754833/cytotoxicity-and-genotoxicity-in-liver-cells-induced-by-cobalt-nanoparticles-and-ions
#18
Y K Liu, X X Deng, H L Yang
OBJECTIVES: The cytotoxicity induced by cobalt ions (Co(2+)) and cobalt nanoparticles (Co-NPs) which released following the insertion of a total hip prosthesis, has been reported. However, little is known about the underlying mechanisms. In this study, we investigate the toxic effect of Co(2+) and Co-NPs on liver cells, and explain further the potential mechanisms. METHODS: Co-NPs were characterised for size, shape, elemental analysis, and hydrodynamic diameter, and were assessed by Transmission Electron Microscope, Scanning Electron Microscope, Energy Dispersive X-ray Spectroscopy and Dynamic Light Scattering...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27729312/biomechanical-analysis-of-the-effect-of-congruence-depth-and-radius-on-the-stability-ratio-of-a-simplistic-ball-and-socket-joint-model
#19
L Ernstbrunner, J-D Werthel, T Hatta, A R Thoreson, H Resch, K-N An, P Moroder
OBJECTIVES: The bony shoulder stability ratio (BSSR) allows for quantification of the bony stabilisers in vivo. We aimed to biomechanically validate the BSSR, determine whether joint incongruence affects the stability ratio (SR) of a shoulder model, and determine the correct parameters (glenoid concavity versus humeral head radius) for calculation of the BSSR in vivo. METHODS: Four polyethylene balls (radii: 19.1 mm to 38.1 mm) were used to mould four fitting sockets in four different depths (3...
October 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27688598/radiological-images-are-shadows-of-reality
#20
EDITORIAL
S T Donell
No abstract text is available yet for this article.
September 2016: Bone & Joint Research
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