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Bone & Joint Research

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https://www.readbyqxmd.com/read/28899856/release-of-the-tourniquet-immediately-after-the-implantation-of-the-components-reduces-the-incidence-of-deep-vein-thrombosis-after-primary-total-knee-arthroplasty
#1
P Zan, M O Mol, J J Yao, L Fan, D Yang, K Liu, G Li
AIMS: The length of the tourniquet time during total knee arthroplasty (TKA) is related to the incidence of post-operative deep vein thrombosis (DVT). Our aim in this study was to investigate the effect of the early release of the tourniquet on the incidence of DVT in patients undergoing TKA. METHODS: A total of 200 patients who underwent TKA between November 2015 and November 2016 were prospectively enrolled. The tourniquet was inflated before surgery and released immediately after the introduction of the components (early release group)...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28899855/a-simple-method-of-measuring-the-wear-of-explanted-acetabular-component-inserts
#2
L Krakow, A Klockow, E Roehner, S Brodt, H Eijer, J Bossert, G Matziolis
AIMS: The determination of the volumetric polyethylene wear on explanted material requires complicated equipment, which is not available in many research institutions. Our aim in this study was to present and validate a method that only requires a set of polyetheretherketone balls and a laboratory balance to determine wear. METHODS: The insert to be measured was placed on a balance, and a ball of the appropriate diameter was inserted. The cavity remaining between the ball and insert caused by wear was filled with contrast medium and the weight of the contrast medium was recorded...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28855192/the-effect-of-implant-position-on-bone-strain-following-lateral-unicompartmental-knee-arthroplasty-a-biomechanical-model-using-digital-image-correlation
#3
A M Ali, S D S Newman, P A Hooper, C M Davies, J P Cobb
OBJECTIVES: Unicompartmental knee arthroplasty (UKA) is a demanding procedure, with tibial component subsidence or pain from high tibial strain being potential causes of revision. The optimal position in terms of load transfer has not been documented for lateral UKA. Our aim was to determine the effect of tibial component position on proximal tibial strain. METHODS: A total of 16 composite tibias were implanted with an Oxford Domed Lateral Partial Knee implant using cutting guides to define tibial slope and resection depth...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28855191/three-dimensional-knee-kinematic-analysis-during-treadmill-gait-slow-imposed-speed-versus-normal-self-selected-speed
#4
N Mannering, T Young, T Spelman, P F Choong
OBJECTIVES: Whilst gait speed is variable between healthy and injured adults, the extent to which speed alone alters the 3D in vivo knee kinematics has not been fully described. The purpose of this prospective study was to understand better the spatiotemporal and 3D knee kinematic changes induced by slow compared with normal self-selected walking speeds within young healthy adults. METHODS: A total of 26 men and 25 women (18 to 35 years old) participated in this study...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28851695/thompson-hemiarthroplasty-versus-modular-unipolar-implants-for-patients-requiring-hemiarthroplasty-of-the-hip-a-systematic-review-of-the-evidence
#5
A L Sims, A J Farrier, M R Reed, T A Sheldon
OBJECTIVES: The objective of this study was to assess all evidence comparing the Thompson monoblock hemiarthroplasty with modular unipolar implants for patients requiring hemiarthroplasty of the hip with respect to mortality and complications. METHODS: A literature search was performed to identify all relevant literature. The population consisted of patients undergoing hemiarthroplasty of the hip for fracture. The intervention was hemiarthroplasty of the hip with a comparison between Thompson and modular unipolar prostheses...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28851694/dose-optimisation-of-intravenous-tranexamic-acid-for-elective-hip-and-knee-arthroplasty-the-effectiveness-of-a-single-pre-operative-dose
#6
R J M Morrison, B Tsang, W Fishley, I Harper, J C Joseph, M R Reed
OBJECTIVES: We have increased the dose of tranexamic acid (TXA) in our enhanced total joint recovery protocol at our institution from 15 mg/kg to 30 mg/kg (maximum 2.5 g) as a single, intravenous (IV) dose. We report the clinical effect of this dosage change. METHODS: We retrospectively compared two cohorts of consecutive patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) surgery in our unit between 2008 and 2013. One group received IV TXA 15 mg/kg, maximum 1...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28835445/angiogenic-conditioning-of-peripheral-blood-mononuclear-cells-promotes-fracture-healing
#7
K Mifuji, M Ishikawa, N Kamei, R Tanaka, K Arita, H Mizuno, T Asahara, N Adachi, M Ochi
OBJECTIVES: The objective of this study was to investigate the therapeutic effect of peripheral blood mononuclear cells (PBMNCs) treated with quality and quantity control culture (QQ-culture) to expand and fortify angiogenic cells on the acceleration of fracture healing. METHODS: Human PBMNCs were cultured for seven days with the QQ-culture method using a serum-free medium containing five specific cytokines and growth factors. The QQ-cultured PBMNCs (QQMNCs) obtained were counted and characterised by flow cytometry and real-time polymerase chain reaction (RT-PCR)...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28790037/a-six-year-retrospective-analysis-of-cut-out-risk-predictors-in-cephalomedullary-nailing-for-pertrochanteric-fractures-can-the-tip-apex-distance-tad-still-be-considered-the-best-parameter
#8
G Caruso, M Bonomo, G Valpiani, G Salvatori, A Gildone, V Lorusso, L Massari
OBJECTIVES: Intramedullary fixation is considered the most stable treatment for pertrochanteric fractures of the proximal femur and cut-out is one of the most frequent mechanical complications. In order to determine the role of clinical variables and radiological parameters in predicting the risk of this complication, we analysed the data pertaining to a group of patients recruited over the course of six years. METHODS: A total of 571 patients were included in this study, which analysed the incidence of cut-out in relation to several clinical variables: age; gender; the AO Foundation and Orthopaedic Trauma Association classification system (AO/OTA); type of nail; cervical-diaphyseal angle; surgical wait times; anti-osteoporotic medication; complete post-operative weight bearing; and radiological parameters (namely the lag-screw position with respect to the femoral head, the Cleveland system, the tip-apex distance (TAD), and the calcar-referenced tip-apex distance (CalTAD))...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28790036/surgical-treatment-of-femoroacetabular-impingement-following-slipped-capital-femoral-epiphysis-a-systematic-review
#9
K O Oduwole, D de Sa, J Kay, F Findakli, A Duong, N Simunovic, Y Yi-Meng, O R Ayeni
OBJECTIVES: The purpose of this study was to evaluate the existing literature from 2005 to 2016 reporting on the efficacy of surgical management of patients with femoroacetabular impingement (FAI) secondary to slipped capital femoral epiphysis (SCFE). METHODS: The electronic databases MEDLINE, EMBASE, and PubMed were searched and screened in duplicate. Data such as patient demographics, surgical technique, surgical outcomes and complications were retrieved from eligible studies...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28784704/inhibition-of-microrna-214-5p-promotes-cell-survival-and-extracellular-matrix-formation-by-targeting-collagen-type-iv-alpha-1-in-osteoblastic-mc3t3-e1-cells
#10
Q S Li, F Y Meng, Y H Zhao, C L Jin, J Tian, X J Yi
OBJECTIVES: This study aimed to investigate the functional effects of microRNA (miR)-214-5p on osteoblastic cells, which might provide a potential role of miR-214-5p in bone fracture healing. METHODS: Blood samples were obtained from patients with hand fracture or intra-articular calcaneal fracture and from healthy controls (HCs). Expression of miR-214-5p was monitored by qRT-PCR at day 7, 14 and 21 post-surgery. Mouse osteoblastic MC3T3-E1 cells were transfected with antisense oligonucleotides (ASO)-miR-214-5p, collagen type IV alpha 1 (COL4A1) vector or their controls; thereafter, cell viability, apoptotic rate, and the expression of collagen type I alpha 1 (COL1A1), type II collagen (COL-II), and type X collagen (COL-X) were determined...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28765269/the-efficacy-and-safety-of-vertebral-fracture-prevention-therapies-in-post-menopausal-osteoporosis-treatment-which-therapies-work-best-a-network-meta-analysis
#11
G Wang, L Sui, P Gai, G Li, X Qi, X Jiang
OBJECTIVES: Osteoporosis has become an increasing concern for older people as it may potentially lead to osteoporotic fractures. This study is designed to assess the efficacy and safety of ten therapies for post-menopausal women using network meta-analysis. METHODS: We conducted a systematic search in several databases, including PubMed and Embase. A random-effects model was employed and results were assessed by the odds ratio (OR) and corresponding 95% confidence intervals (CI)...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28765268/the-achilles-tendon-and-the-retrocalcaneal-bursa-an-anatomical-and-radiological-study
#12
P A Pękala, B M Henry, J R Pękala, K Piska, K A Tomaszewski
OBJECTIVES: Inflammation of the retrocalcaneal bursa (RB) is a common clinical problem, particularly in professional athletes. RB inflammation is often treated with corticosteroid injections however a number of reports suggest an increased risk of Achilles tendon (AT) rupture. The aim of this cadaveric study was to describe the anatomical connections of the RB and to investigate whether it is possible for fluid to move from the RB into AT tissue. METHODS: A total of 20 fresh-frozen AT specimens were used...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28747338/copy-number-loss-in-the-region-of-the-aspn-gene-in-patients-with-acetabular-dysplasia-aspn-cnv-in-acetabular-dysplasia
#13
T Sekimoto, M Ishii, M Emi, S Kurogi, T Funamoto, Y Yonezawa, T Tajima, T Sakamoto, H Hamada, E Chosa
OBJECTIVES: We have previously investigated an association between the genome copy number variation (CNV) and acetabular dysplasia (AD). Hip osteoarthritis is associated with a genetic polymorphism in the aspartic acid repeat in the N-terminal region of the asporin (ASPN) gene; therefore, the present study aimed to investigate whether the CNV of ASPN is involved in the pathogenesis of AD. METHODS: Acetabular coverage of all subjects was evaluated using radiological findings (Sharp angle, centre-edge (CE) angle, acetabular roof obliquity (ARO) angle, and minimum joint space width)...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28747337/comparisons-of-external-fixator-combined-with-limited-internal-fixation-and-open-reduction-and-internal-fixation-for-sanders-type-2-calcaneal-fractures-finite-element-analysis-and-clinical-outcome
#14
M Pan, L Chai, F Xue, L Ding, G Tang, B Lv
OBJECTIVES: The aim of this study was to compare the biomechanical stability and clinical outcome of external fixator combined with limited internal fixation (EFLIF) and open reduction and internal fixation (ORIF) in treating Sanders type 2 calcaneal fractures. METHODS: Two types of fixation systems were selected for finite element analysis and a dual cohort study. Two fixation systems were simulated to fix the fracture in a finite element model. The relative displacement and stress distribution were analysed and compared...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28733366/the-available-evidence-on-demineralised-bone-matrix-in-trauma-and-orthopaedic-surgery-a-systematic-review
#15
J van der Stok, K A Hartholt, D A L Schoenmakers, J J C Arts
OBJECTIVES: The aim of this systematic literature review was to assess the clinical level of evidence of commercially available demineralised bone matrix (DBM) products for their use in trauma and orthopaedic related surgery. METHODS: A total of 17 DBM products were used as search terms in two available databases: Embase and PubMed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses statement. All articles that reported the clinical use of a DBM-product in trauma and orthopaedic related surgery were included...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28720606/re-using-blood-products-as-an-alternative-supplement-in-the-optimisation-of-clinical-grade-adipose-derived-mesenchymal-stem-cell-culture
#16
J Phetfong, T Tawonsawatruk, K Seenprachawong, A Srisarin, C Isarankura-Na-Ayudhya, A Supokawej
OBJECTIVES: Adipose-derived mesenchymal stem cells (ADMSCs) are a promising strategy for orthopaedic applications, particularly in bone repair. Ex vivo expansion of ADMSCs is required to obtain sufficient cell numbers. Xenogenic supplements should be avoided in order to minimise the risk of infections and immunological reactions. Human platelet lysate and human plasma may be an excellent material source for ADMSC expansion. In the present study, use of blood products after their recommended transfusion date to prepare human platelet lysate (HPL) and human plasma (Hplasma) was evaluated for in vitro culture expansion and osteogenesis of ADMSCs...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28710154/outcomes-following-revision-surgery-performed-for-adverse-reactions-to-metal-debris-in-non-metal-on-metal-hip-arthroplasty-patients-analysis-of-185-revisions-from-the-national-joint-registry-for-england-and-wales
#17
G S Matharu, A Judge, D W Murray, H G Pandit
OBJECTIVES: Few studies have assessed outcomes following non-metal-on-metal hip arthroplasty (non-MoMHA) revision surgery performed for adverse reactions to metal debris (ARMD). We assessed outcomes following non-MoMHA revision surgery performed for ARMD, and identified predictors of re-revision. METHODS: We performed a retrospective observational study using data from the National Joint Registry for England and Wales. All non-MoMHAs undergoing revision surgery for ARMD between 2008 and 2014 were included (185 hips in 185 patients)...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28663339/the-influence-of-connective-tissue-growth-factor-on-rabbit-ligament-injury-repair
#18
X Sun, W Liu, G Cheng, X Qu, H Bi, Z Cao, Q Yu
OBJECTIVES: The injured anterior cruciate ligament (ACL) is thought to exhibit an impaired healing response, and attempts at surgical repair have not been successful. Connective tissue growth factor (CTGF) is reported to be associated with wound healing, probably through transforming growth factor beta 1 (TGF-β1). METHODS: A rabbit ACL injury model was used to study the effect of CTGF on ligament recovery. Quantitative real-time PCR (qRT-PCR) was performed for detection of changes in RNA levels of TGF-β1, type 1 collagen (COL1), type 2 collagen (COL2), SRY-related high mobility group-box gene9 (SOX9), tissue inhibitor of metalloproteinase-1 (TIMP-1) and matrix metallopeptidase 13 (MMP-13)...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28642256/revision-for-prosthetic-joint-infection-following-hip-arthroplasty-evidence-from-the-national-joint-registry
#19
E Lenguerrand, M R Whitehouse, A D Beswick, S A Jones, M L Porter, A W Blom
OBJECTIVES: We used the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR) to investigate the risk of revision due to prosthetic joint infection (PJI) for patients undergoing primary and revision hip arthroplasty, the changes in risk over time, and the overall burden created by PJI. METHODS: We analysed revision total hip arthroplasties (THAs) performed due to a diagnosis of PJI and the linked index procedures recorded in the NJR between 2003 and 2014...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28634158/stem-cell-therapy-for-enhancement-of-bone-consolidation-in-distraction-osteogenesis-a-contemporary-review-of-experimental-studies
#20
Y Yang, S Lin, B Wang, W Gu, G Li
OBJECTIVES: Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results. METHODS: We hereby review the published literature on the use of MSCs in promoting bone consolidation during DO. RESULTS: Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods...
June 2017: Bone & Joint Research
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