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Bone & Joint Research

J F A Eijkenboom, J H Waarsing, E H G Oei, S M A Bierma-Zeinstra, M van Middelkoop
Objectives: It has been hypothesized that patellofemoral pain, a common knee condition in adolescents and young adults, may be a precursor of degenerative joint changes and may ultimately lead to patellofemoral osteoarthritis. Since both conditions share several mechanical disease characteristics, such as altered contact area between the femur and patella and increased joint stress, we investigated whether these conditions share similar and different shape characteristics of the patella compared with normal controls...
September 2018: Bone & Joint Research
I R Murray, A G Geeslin, J Chahla, A D Murray, E B Goudie, F A Petrigliano, A H R W Simpson, R F LaPrade
No abstract text is available yet for this article.
September 2018: Bone & Joint Research
S Zhao, M Arnold, S Ma, R L Abel, J P Cobb, U Hansen, O Boughton
Objectives: The ability to determine human bone stiffness is of clinical relevance in many fields, including bone quality assessment and orthopaedic prosthesis design. Stiffness can be measured using compression testing, an experimental technique commonly used to test bone specimens in vitro . This systematic review aims to determine how best to perform compression testing of human bone. Methods: A keyword search of all English language articles up until December 2017 of compression testing of bone was undertaken in Medline, Embase, PubMed, and Scopus databases...
August 2018: Bone & Joint Research
S T J Tsang, P J Gwynne, M P Gallagher, A H R W Simpson
Objectives: Periprosthetic joint infection following joint arthroplasty surgery is one of the most feared complications. The key to successful revision surgery for periprosthetic joint infections, regardless of treatment strategy, is a thorough deep debridement. In an attempt to limit antimicrobial and disinfectant use, there has been increasing interest in the use of acetic acid as an adjunct to debridement in the management of periprosthetic joint infections. However, its effectiveness in the eradication of established biofilms following clinically relevant treatment times has not been established...
August 2018: Bone & Joint Research
M Beverly, S Mellon, J A Kennedy, D W Murray
Objectives: We studied subchondral intraosseous pressure (IOP) in an animal model during loading, and with vascular occlusion. We explored bone compartmentalization by saline injection. Materials and Methods: Needles were placed in the femoral condyle and proximal tibia of five anaesthetized rabbits and connected to pressure recorders. The limb was loaded with and without proximal vascular occlusion. An additional subject had simultaneous triple recordings at the femoral head, femoral condyle and proximal tibia...
August 2018: Bone & Joint Research
S Horriat, F S Haddad
No abstract text is available yet for this article.
August 2018: Bone & Joint Research
C-B Phan, D-P Nguyen, K M Lee, S Koo
Objectives: The objective of this study was to quantify the relative movement between the articular surfaces in the tibiotalar and subtalar joints during normal walking in asymptomatic individuals. Methods: 3D movement data of the ankle joint complex were acquired from 18 subjects using a biplanar fluoroscopic system and 3D-to-2D registration of bone models obtained from CT images. Surface relative velocity vectors (SRVVs) of the articular surfaces of the tibiotalar and subtalar joints were calculated...
August 2018: Bone & Joint Research
L Jiang, X Zhu, J Rong, B Xing, S Wang, A Liu, M Chu, G Huang
Objectives: Given the function of adiponectin (ADIPOQ) on the inflammatory condition of obesity and osteoarthritis (OA), we hypothesized that the ADIPOQ gene might be a candidate gene for a marker of susceptibility to OA. Methods: We systematically screened three tagging polymorphisms (rs182052, rs2082940 and rs6773957) in the ADIPOQ gene, and evaluated the association between the genetic variants and OA risk in a case-controlled study that included 196 OA patients and 442 controls in a northern Chinese population...
July 2018: Bone & Joint Research
Y Numata, A Kaneuji, L Kerboull, E Takahashi, T Ichiseki, K Fukui, J Tsujioka, N Kawahara
Objective: Cement thickness of at least 2 mm is generally associated with more favorable results for the femoral component in cemented hip arthroplasty. However, French-designed stems have shown favorable outcomes even with thin cement mantle. The biomechanical behaviors of a French stem, Charnley-Marcel-Kerboull (CMK) and cement were researched in this study. Methods: Six polished CMK stems were implanted into a composite femur, and one million times dynamic loading tests were performed...
July 2018: Bone & Joint Research
V C Panagiotopoulou, K Davda, H S Hothi, J Henckel, A Cerquiglini, W D Goodier, J Skinner, A Hart, P R Calder
Objectives: The Precice nail is the latest intramedullary lengthening nail with excellent early outcomes. Implant complications have led to modification of the nail design. The aim of this study was to perform a retrieval study of Precice nails following lower-limb lengthening and to assess macroscopical and microscopical changes to the implants and evaluate differences following design modification, with the aim of identifying potential surgical, implant, and patient risk factors. Methods: A total of 15 nails were retrieved from 13 patients following lower-limb lengthening...
July 2018: Bone & Joint Research
Q-F He, H Sun, L-Y Shu, Y Zhu, X-T Xie, Y Zhan, C-F Luo
Objectives: Researchers continue to seek easier ways to evaluate the quality of bone and screen for osteoporosis and osteopenia. Until recently, radiographic images of various parts of the body, except the distal femur, have been reappraised in the light of dual-energy X-ray absorptiometry (DXA) findings. The incidence of osteoporotic fractures around the knee joint in the elderly continues to increase. The aim of this study was to propose two new radiographic parameters of the distal femur for the assessment of bone quality...
July 2018: Bone & Joint Research
I D M Smith, K M Milto, C J Doherty, S G B Amyes, A H R W Simpson, A C Hall
Objectives: Staphylococcus aureus ( S. aureus ) is the most commonly implicated organism in septic arthritis, a condition that may be highly destructive to articular cartilage. Previous studies investigating laboratory and clinical strains of S. aureus have demonstrated that potent toxins induced significant chondrocyte death, although the precise toxin or toxins that were involved was unknown. In this study, we used isogenic S. aureus mutants to assess the influence of alpha (Hla)-, beta (Hlb)-, and gamma (Hlg)-haemolysins, toxins considered important for the destruction of host tissue, on in situ bovine chondrocyte viability...
July 2018: Bone & Joint Research
M Morgenstern, A Vallejo, M A McNally, T F Moriarty, J Y Ferguson, S Nijs, W J Metsemakers
Objectives: As well as debridement and irrigation, soft-tissue coverage, and osseous stabilization, systemic antibiotic prophylaxis is considered the benchmark in the management of open fractures and considerably reduces the risk of subsequent fracture-related infections (FRI). The direct application of antibiotics in the surgical field (local antibiotics) has been used for decades as additional prophylaxis in open fractures, although definitive evidence confirming a beneficial effect is scarce...
July 2018: Bone & Joint Research
A K Woods, J Broomfield, P Monk, F Vollrath, S Glyn-Jones
Objectives: The aim of this study was to investigate the structural integrity of torn and non-torn human acetabular labral tissue. Methods: A total of 47 human labral specimens were obtained from a biobank. These included 22 torn specimens and 25 control specimens from patients undergoing total hip arthroplasty with macroscopically normal labra. The specimens underwent dynamic shear analysis using a rheometer to measure storage modulus, as an indicator of structural integrity...
July 2018: Bone & Joint Research
F Eggermont, L C Derikx, N Verdonschot, I C M van der Geest, M A A de Jong, A Snyers, Y M van der Linden, E Tanck
Objectives: In this prospective cohort study, we investigated whether patient-specific finite element (FE) models can identify patients at risk of a pathological femoral fracture resulting from metastatic bone disease, and compared these FE predictions with clinical assessments by experienced clinicians. Methods: A total of 39 patients with non-fractured femoral metastatic lesions who were irradiated for pain were included from three radiotherapy institutes. During follow-up, nine pathological fractures occurred in seven patients...
June 2018: Bone & Joint Research
Y P Acklin, I Zderic, J A Inzana, S Grechenig, R Schwyn, R G Richards, B Gueorguiev
Aims: Plating displaced proximal humeral fractures is associated with a high rate of screw perforation. Dynamization of the proximal screws might prevent these complications. The aim of this study was to develop and evaluate a new gliding screw concept for plating proximal humeral fractures biomechanically. Methods: Eight pairs of three-part humeral fractures were randomly assigned for pairwise instrumentation using either a prototype gliding plate or a standard PHILOS plate, and four pairs were fixed using the gliding plate with bone cement augmentation of its proximal screws...
June 2018: Bone & Joint Research
C D Yu, W H Miao, Y Y Zhang, M J Zou, X F Yan
Objectives: The aim of this study was to investigate the role of miR-126 in the development of osteoarthritis, as well as the potential molecular mechanisms involved, in order to provide a theoretical basis for osteoarthritis treatment and a novel perspective for clinical therapy. Methods: Human chondrocyte cell line CHON-001 was administrated by different doses of interleukin (IL)-1β to simulate inflammation. Cell viability, migration, apoptosis, IL-6, IL-8, and tumour necrosis factor (TNF)-α expression, as well as expression of apoptosis-related factors, were measured to assess inflammation...
June 2018: Bone & Joint Research
M Shabestari, N J Kise, M A Landin, S Sesseng, J C Hellund, J E Reseland, E F Eriksen, I K Haugen
Objectives: Little is known about tissue changes underlying bone marrow lesions (BMLs) in non-weight-bearing joints with osteoarthritis (OA). Our aim was to characterize BMLs in OA of the hand using dynamic histomorphometry. We therefore quantified bone turnover and angiogenesis in subchondral bone at the base of the thumb, and compared the findings with control bone from hip OA. Methods: Patients with OA at the base of the thumb, or the hip, underwent preoperative MRI to assess BMLs, and tetracycline labelling to determine bone turnover...
June 2018: Bone & Joint Research
M W Morcos, H Al-Jallad, J Li, C Farquharson, J L Millán, R C Hamdy, M Murshed
Objectives: Bone fracture healing is regulated by a series of complex physicochemical and biochemical processes. One of these processes is bone mineralization, which is vital for normal bone development. Phosphatase, orphan 1 (PHOSPHO1), a skeletal tissue-specific phosphatase, has been shown to be involved in the mineralization of the extracellular matrix and to maintain the structural integrity of bone. In this study, we examined how PHOSPHO1 deficiency might affect the healing and quality of fracture callus in mice...
June 2018: Bone & Joint Research
D J Langton, R P Sidaginamale, T J Joyce, J G Bowsher, J P Holland, D Deehan, A V F Nargol, S Natu
Objectives: We have encountered patients who developed large joint fluid collections with massive elevations in chromium (Cr) and cobalt (Co) concentrations following metal-on-metal (MoM) hip arthroplasties. In some cases, retrieval analysis determined that these ion concentrations could not be explained simply by the wear rates of the components. We hypothesized that these effects may be associated with aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL). Patients and Methods: We examined the influence of the ALVAL grade on synovial fluid Co and Cr concentrations following adjustment for patient and device variables, including volumetric wear rates...
June 2018: Bone & Joint Research
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