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Bone & Joint Research

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https://www.readbyqxmd.com/read/28642256/revision-for-prosthetic-joint-infection-following-hip-arthroplasty-evidence-from-the-national-joint-registry
#1
E Lenguerrand, M R Whitehouse, A D Beswick, S A Jones, M L Porter, A W Blom
OBJECTIVES: We used the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR) to investigate the risk of revision due to prosthetic joint infection (PJI) for patients undergoing primary and revision hip arthroplasty, the changes in risk over time, and the overall burden created by PJI. METHODS: We analysed revision total hip arthroplasties (THAs) performed due to a diagnosis of PJI and the linked index procedures recorded in the NJR between 2003 and 2014...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28634158/stem-cell-therapy-for-enhancement-of-bone-consolidation-in-distraction-osteogenesis-a-contemporary-review-of-experimental-studies
#2
Y Yang, S Lin, B Wang, W Gu, G Li
OBJECTIVES: Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results. METHODS: We hereby review the published literature on the use of MSCs in promoting bone consolidation during DO. RESULTS: Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28600383/validation-of-static-and-dynamic-radiostereometric-analysis-of-the-knee-joint-using-bone-models-from-ct-data
#3
K Stentz-Olesen, E T Nielsen, S De Raedt, P B Jørgensen, O G Sørensen, B L Kaptein, M S Andersen, M Stilling
OBJECTIVES: Static radiostereometric analysis (RSA) using implanted markers is considered the most accurate system for the evaluation of prosthesis migration. By using CT bone models instead of markers, combined with a dynamic RSA system, a non-invasive measurement of joint movement is enabled. This method is more accurate than current 3D skin marker-based tracking systems. The purpose of this study was to evaluate the accuracy of the CT model method for measuring knee joint kinematics in static and dynamic RSA using the marker method as the benchmark...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28600382/in-vivo-and-clinical-application-of-strontium-enriched-biomaterials-for-bone-regeneration-a-systematic-review
#4
N Neves, D Linhares, G Costa, C C Ribeiro, M A Barbosa
OBJECTIVES: This systematic review aimed to assess the in vivo and clinical effect of strontium (Sr)-enriched biomaterials in bone formation and/or remodelling. METHODS: A systematic search was performed in Pubmed, followed by a two-step selection process. We included in vivo original studies on Sr-containing biomaterials used for bone support or regeneration, comparing at least two groups that only differ in Sr addition in the experimental group. RESULTS: A total of 572 references were retrieved and 27 were included...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28576885/osteoporosis-and-ageing-affects-the-migration-of-stem-cells-and-this-is-ameliorated-by-transfection-with-cxcr4
#5
A Sanghani-Kerai, M Coathup, S Samazideh, P Kalia, L Di Silvio, B Idowu, G Blunn
OBJECTIVES: Cellular movement and relocalisation are important for many physiologic properties. Local mesenchymal stem cells (MSCs) from injured tissues and circulating MSCs aid in fracture healing. Cytokines and chemokines such as Stromal cell-derived factor 1(SDF-1) and its receptor chemokine receptor type 4 (CXCR4) play important roles in maintaining mobilisation, trafficking and homing of stem cells from bone marrow to the site of injury. We investigated the differences in migration of MSCs from the femurs of young, adult and ovariectomised (OVX) rats and the effect of CXCR4 over-expression on their migration...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28566327/the-influence-of-cement-thickness-on-stem-subsidence-and-cement-creep-in-a-collarless-polished-tapered-stem-when-are-thick-cement-mantles-detrimental
#6
E Takahashi, A Kaneuji, R Tsuda, Y Numata, T Ichiseki, K Fukui, N Kawahara
OBJECTIVES: Favourable results for collarless polished tapered stems have been reported, and cement creep due to taper slip may be a contributing factor. However, the ideal cement thickness around polished stems remains unknown. We investigated the influence of cement thickness on stem subsidence and cement creep. METHODS: We cemented six collarless polished tapered (CPT) stems (two stems each of small, medium and large sizes) into composite femurs that had been reamed with a large CPT rasp to achieve various thicknesses of the cement mantle...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28566326/retrieval-analysis-of-metal-and-ceramic-femoral-heads-on-a-single-cocr-stem-design
#7
A Di Laura, H Hothi, J Henckel, I Swiatkowska, M H L Liow, Y-M Kwon, J A Skinner, A J Hart
OBJECTIVES: The use of ceramic femoral heads in total hip arthroplasty (THA) has increased due to their proven low bearing wear characteristics. Ceramic femoral heads are also thought to reduce wear and corrosion at the head-stem junction with titanium (Ti) stems when compared with metal heads. We sought to evaluate taper damage of ceramic compared with metal heads when paired with cobalt chromium (CoCr) alloy stems in a single stem design. METHODS: This retrieval study involved 48 total hip arthroplasties (THAs) with CoCr V40 trunnions paired with either CoCr (n = 21) or ceramic (n = 27) heads...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28536117/the-association-between-whole-body-sagittal-balance-and-risk-of-falls-among-elderly-patients-seeking-treatment-for-back-pain
#8
J Kim, J Y Hwang, J K Oh, M S Park, S W Kim, H Chang, T-H Kim
OBJECTIVES: The objective of this study was to assess the association between whole body sagittal balance and risk of falls in elderly patients who have sought treatment for back pain. Balanced spinal sagittal alignment is known to be important for the prevention of falls. However, spinal sagittal imbalance can be markedly compensated by the lower extremities, and whole body sagittal balance including the lower extremities should be assessed to evaluate actual imbalances related to falls...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28522447/photofunctionalised-ti6al4v-implants-enhance-early-phase-osseointegration
#9
R Yamauchi, T Itabashi, K Wada, T Tanaka, G Kumagai, Y Ishibashi
OBJECTIVES: Ultraviolet (UV) light-mediated photofunctionalisation is known to improve osseointegration of pure titanium (Ti). However, histological examination of titanium alloy (Ti6Al4V), which is frequently applied in orthopaedic and dental surgery, has not yet been performed. This study examined the osseointegration of photofunctionalised Ti6Al4V implants. METHODS: Ti and Ti6Al4V implants were treated with UV light, and the chemical composition and contact angle on the surfaces were evaluated to confirm photofunctionalisation...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28522446/non-contact-electromagnetic-induction-heating-for-eradicating-bacteria-and-yeasts-on-biomaterials-and-possible-relevance-to-orthopaedic-implant-infections-in-vitro-findings
#10
B G Pijls, I M J G Sanders, E J Kuijper, R G H H Nelissen
OBJECTIVES: Infection of implants is a major problem in elective and trauma surgery. Heating is an effective way to reduce the bacterial load in food preparation, and studies on hyperthermia treatment for cancer have shown that it is possible to heat metal objects with pulsed electromagnetic fields selectively (PEMF), also known as induction heating. We therefore set out to answer the following research question: is non-contact induction heating of metallic implants effective in reducing bacterial load in vitro? METHODS: Titanium alloy cylinders (Ti6Al4V) were exposed to PEMF from an induction heater with maximum 2000 watts at 27 kHz after being contaminated with five different types of micro-organisms: Staphylococcus epidermidis; Staphylococcus aureus; Pseudomonas aeruginosa; spore-forming Bacillus cereus; and yeast Candida albicans...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28522445/evaluation-of-bacterial-adherence-of-clinical-isolates-of-staphylococcus-sp-using-a-competitive-model-an-in-vitro-approach-to-the-race-for-the-surface-theory
#11
M Martinez-Perez, C Perez-Jorge, D Lozano, S Portal-Nuñez, R Perez-Tanoira, A Conde, M A Arenas, J M Hernandez-Lopez, J J de Damborenea, E Gomez-Barrena, P Esbrit, J Esteban
OBJECTIVES: Implant-related infection is one of the most devastating complications in orthopaedic surgery. Many surface and/or material modifications have been developed in order to minimise this problem; however, most of the in vitro studies did not evaluate bacterial adhesion in the presence of eukaryotic cells, as stated by the 'race for the surface' theory. Moreover, the adherence of numerous clinical strains with different initial concentrations has not been studied. METHODS: We describe a method for the study of bacterial adherence in the presence of preosteoblastic cells...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28515060/barriers-and-facilitators-experienced-in-collaborative-prospective-research-in-orthopaedic-oncology-a-qualitative-study
#12
J S Rendon, M Swinton, N Bernthal, M Boffano, T Damron, N Evaniew, P Ferguson, M Galli Serra, W Hettwer, P McKay, B Miller, L Nystrom, W Parizzia, P Schneider, A Spiguel, R Vélez, K Weiss, J P Zumárraga, M Ghert
OBJECTIVES: As tumours of bone and soft tissue are rare, multicentre prospective collaboration is essential for meaningful research and evidence-based advances in patient care. The aim of this study was to identify barriers and facilitators encountered in large-scale collaborative research by orthopaedic oncological surgeons involved or interested in prospective multicentre collaboration. METHODS: All surgeons who were involved, or had expressed an interest, in the ongoing Prophylactic Antibiotic Regimens in Tumour Surgery (PARITY) trial were invited to participate in a focus group to discuss their experiences with collaborative research in this area...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28515059/antibiotic-stability-over-six-weeks-in-aqueous-solution-at-body-temperature-with-and-without-heat-treatment-that-mimics-the-curing-of-bone-cement
#13
E Samara, T F Moriarty, L A Decosterd, R G Richards, E Gautier, P Wahl
OBJECTIVES: Thermal stability is a key property in determining the suitability of an antibiotic agent for local application in the treatment of orthopaedic infections. Despite the fact that long-term therapy is a stated goal of novel local delivery carriers, data describing thermal stability over a long period are scarce, and studies that avoid interference from specific carrier materials are absent from the orthopaedic literature. METHODS: In this study, a total of 38 frequently used antibiotic agents were maintained at 37°C in saline solution, and degradation and antibacterial activity assessed over six weeks...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28515058/tissue-engineered-cartilage-constructed-by-a-biotin-conjugated-anti-cd44-avidin-binding-technique-for-the-repairing-of-cartilage-defects-in-the-weight-bearing-area-of-knee-joints-in-pigs
#14
H Lin, J Zhou, L Cao, H R Wang, J Dong, Z R Chen
OBJECTIVES: The lack of effective treatment for cartilage defects has prompted investigations using tissue engineering techniques for their regeneration and repair. The success of tissue-engineered repair of cartilage may depend on the rapid and efficient adhesion of transplanted cells to a scaffold. Our aim in this study was to repair full-thickness defects in articular cartilage in the weight-bearing area of a porcine model, and to investigate whether the CD44 monoclonal antibody biotin-avidin (CBA) binding technique could provide satisfactory tissue-engineered cartilage...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28473335/evaluation-of-autologous-skeletal-muscle-derived-factors-for-regenerative-medicine-applications
#15
M Yoshikawa, T Nakasa, M Ishikawa, N Adachi, M Ochi
OBJECTIVES: Regenerative medicine is an emerging field aimed at the repair and regeneration of various tissues. To this end, cytokines (CKs), growth factors (GFs), and stem/progenitor cells have been applied in this field. However, obtaining and preparing these candidates requires invasive, costly, and time-consuming procedures. We hypothesised that skeletal muscle could be a favorable candidate tissue for the concept of a point-of-care approach. The purpose of this study was to characterize and confirm the biological potential of skeletal muscle supernatant for use in regenerative medicine...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28473334/the-efficacy-of-rotational-control-designs-in-promoting-torsional-stability-of-hip-fracture-fixation
#16
J D Gosiewski, T P Holsgrove, H S Gill
OBJECTIVES: Fractures of the proximal femur are a common clinical problem, and a number of orthopaedic devices are available for the treatment of such fractures. The objective of this study was to assess the rotational stability, a common failure predictor, of three different rotational control design philosophies: a screw, a helical blade and a deployable crucifix. METHODS: Devices were compared in terms of the mechanical work (W) required to rotate the implant by 6° in a bone substitute material...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28473333/the-clinical-and-cost-effectiveness-of-a-virtual-fracture-clinic-service-an-interrupted-time-series-analysis-and-before-and-after-comparison
#17
A McKirdy, A M Imbuldeniya
OBJECTIVES: To assess the clinical and cost-effectiveness of a virtual fracture clinic (VFC) model, and supplement the literature regarding this service as recommended by The National Institute for Health and Care Excellence (NICE) and the British Orthopaedic Association (BOA). METHODS: This was a retrospective study including all patients (17 116) referred to fracture clinics in a London District General Hospital from May 2013 to April 2016, using hospital-level data...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28450318/the-protective-role-of-nitric-oxide-dependent-innate-immunosuppression-in-the-early-stage-of-cartilage-damage-in-rats-role-of-nitric-oxide-in-cartilage-damage
#18
C-C Hsu, C-L Lin, I-M Jou, P-H Wang, J-S Lee
OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis, affecting approximately 15% of the human population. Recently, increased concentration of nitric oxide in serum and synovial fluid in patients with OA has been observed. However, the exact role of nitric oxide in the initiation of OA has not been elucidated. The aim of the present study was to investigate the role of nitric oxide in innate immune regulation during OA initiation in rats. METHODS: Rat OA was induced by performing meniscectomy surgery while cartilage samples were collected 0, 7, and 14 days after surgery...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28450317/the-segment-dependent-changes-in-lumbar-intervertebral-space-height-during-flexion-extension-motion
#19
M Fu, Q Ye, C Jiang, L Qian, D Xu, Y Wang, P Sun, J Ouyang
OBJECTIVES: Many studies have investigated the kinematics of the lumbar spine and the morphological features of the lumbar discs. However, the segment-dependent immediate changes of the lumbar intervertebral space height during flexion-extension motion are still unclear. This study examined the changes of intervertebral space height during flexion-extension motion of lumbar specimens. METHODS: First, we validated the accuracy and repeatability of a custom-made mechanical loading equipment set-up...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28450316/the-combined-use-of-kartogenin-and-platelet-rich-plasma-promotes-fibrocartilage-formation-in-the-wounded-rat-achilles-tendon-entheses
#20
J Zhang, T Yuan, N Zheng, Y Zhou, M V Hogan, J H-C Wang
OBJECTIVES: After an injury, the biological reattachment of tendon to bone is a challenge because healing takes place between a soft (tendon) and a hard (bone) tissue. Even after healing, the transition zone in the enthesis is not completely regenerated, making it susceptible to re-injury. In this study, we aimed to regenerate Achilles tendon entheses (ATEs) in wounded rats using a combination of kartogenin (KGN) and platelet-rich plasma (PRP). METHODS: Wounds created in rat ATEs were given three different treatments: kartogenin platelet-rich plasma (KGN-PRP); PRP; or saline (control), followed by histological and immunochemical analyses, and mechanical testing of the rat ATEs after three months of healing...
April 2017: Bone & Joint Research
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