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Bone & Joint Research

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https://www.readbyqxmd.com/read/29682286/maximizing-the-fixation-strength-of-modular-components-by-impaction-without-tissue-damage
#1
A Krull, M M Morlock, N E Bishop
Objectives: Taper junctions between modular hip arthroplasty femoral heads and stems fail by wear or corrosion which can be caused by relative motion at their interface. Increasing the assembly force can reduce relative motion and corrosion but may also damage surrounding tissues. The purpose of this study was to determine the effects of increasing the impaction energy and the stiffness of the impactor tool on the stability of the taper junction and on the forces transmitted through the patient's surrounding tissues...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682285/effects-of-interfacial-micromotions-on-vitality-and-differentiation-of-human-osteoblasts
#2
J Ziebart, S Fan, C Schulze, P W Kämmerer, R Bader, A Jonitz-Heincke
Objectives: Enhanced micromotions between the implant and surrounding bone can impair osseointegration, resulting in fibrous encapsulation and aseptic loosening of the implant. Since the effect of micromotions on human bone cells is sparsely investigated, an in vitro system, which allows application of micromotions on bone cells and subsequent investigation of bone cell activity, was developed. Methods: Micromotions ranging from 25 µm to 100 µm were applied as sine or triangle signal with 1 Hz frequency to human osteoblasts seeded on collagen scaffolds...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682284/staphylococcal-enterotoxin-c2-promotes-osteogenesis-of-mesenchymal-stem-cells-and-accelerates-fracture-healing
#3
T Wu, J Zhang, B Wang, Y Sun, Y Liu, G Li
Objectives: As one of the heat-stable enterotoxins, Staphylococcal enterotoxin C2 (SEC2) is synthesized by Staphylococcus aureus , which has been proved to inhibit the growth of tumour cells, and is used as an antitumour agent in cancer immunotherapy. Although SEC2 has been reported to promote osteogenic differentiation of human mesenchymal stem cells (MSCs), the in vivo function of SCE2 in animal model remains elusive. The aim of this study was to further elucidate the in vivo effect of SCE2 on fracture healing...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682283/the-role-of-ckip-1-in-osteoporosis-development-and-treatment
#4
X Peng, X Wu, J Zhang, G Zhang, G Li, X Pan
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682282/a-pilot-hole-does-not-reduce-the-strains-or-risk-of-fracture-to-the-lateral-cortex-during-and-following-a-medial-opening-wedge-high-tibial-osteotomy-in-cadaveric-specimens
#5
K Bujnowski, A Getgood, K Leitch, J Farr, C Dunning, T A Burkhart
Aim: It has been suggested that the use of a pilot-hole may reduce the risk of fracture to the lateral cortex. Therefore the purpose of this study was to determine the effect of a pilot hole on the strains and occurrence of fractures at the lateral cortex during the opening of a high tibial osteotomy (HTO) and post-surgery loading. Materials and Methods: A total of 14 cadaveric tibias were randomized to either a pilot hole (n = 7) or a no-hole (n = 7) condition...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682281/effects-of-a-phosphocitrate-analogue-on-osteophyte-subchondral-bone-advance-and-bone-marrow-lesions-in-hartley-guinea-pigs
#6
Y Sun, A J Kiraly, A R Sun, M Cox, D R Mauerhan, E N Hanley
Objectives: The objectives of this study were: 1) to examine osteophyte formation, subchondral bone advance, and bone marrow lesions (BMLs) in osteoarthritis (OA)-prone Hartley guinea pigs; and 2) to assess the disease-modifying activity of an orally administered phosphocitrate 'analogue', Carolinas Molecule-01 (CM-01). Methods: Young Hartley guinea pigs were divided into two groups. The first group (n = 12) had drinking water and the second group (n = 9) had drinking water containing CM-01...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29437637/altered-expression-of-microrna-during-fracture-healing-in-diabetic-rats
#7
S Takahara, S Y Lee, T Iwakura, K Oe, T Fukui, E Okumachi, T Waki, M Arakura, Y Sakai, K Nishida, R Kuroda, T Niikura
OBJECTIVES: Diabetes mellitus (DM) is known to impair fracture healing. Increasing evidence suggests that some microRNA (miRNA) is involved in the pathophysiology of diabetes and its complications. We hypothesized that the functions of miRNA and changes to their patterns of expression may be implicated in the pathogenesis of impaired fracture healing in DM. METHODS: Closed transverse fractures were created in the femurs of 116 rats, with half assigned to the DM group and half assigned to the control group...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29437636/outcomes-following-limb-salvage-after-combat-hindfoot-injury-are-inferior-to-delayed-amputation-at-five-years
#8
P M Bennett, T Stevenson, I D Sargeant, A Mountain, J G Penn-Barwell
OBJECTIVES: The surgical challenge with severe hindfoot injuries is one of technical feasibility, and whether the limb can be salvaged. There is an additional question of whether these injuries should be managed with limb salvage, or whether patients would achieve a greater quality of life with a transtibial amputation. This study aims to measure functional outcomes in military patients sustaining hindfoot fractures, and identify injury features associated with poor function. METHODS: Follow-up was attempted in all United Kingdom military casualties sustaining hindfoot fractures...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29437635/pulsed-electromagnetic-field-stimulation-may-improve-fusion-rates-in-cervical-arthrodesis-in-high-risk-populations
#9
D Coric, D E Bullard, V V Patel, J T Ryaby, B L Atkinson, D He, R D Guyer
OBJECTIVES: Pulsed electromagnetic field (PEMF) stimulation was evaluated after anterior cervical discectomy and fusion (ACDF) procedures in a randomized, controlled clinical study performed for United States Food and Drug Administration (FDA) approval. PEMF significantly increased fusion rates at six months, but 12-month fusion outcomes for subjects at elevated risk for pseudoarthrosis were not thoroughly reported. The objective of the current study was to evaluate the effect of PEMF treatment on subjects at increased risk for pseudoarthrosis after ACDF procedures...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29437587/new-insights-into-the-biomechanics-of-legg-calv%C3%A3-perthes-disease-the-role-of-epiphyseal-skeletal-immaturity-in-vascular-obstruction
#10
M Pinheiro, C A Dobson, D Perry, M J Fagan
OBJECTIVES: Legg-Calvé-Perthes' disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed that interruption of the blood supply to the developing epiphysis is an important factor in the development of the condition. METHODS: Finite element analysis modelling of the blood supply to the juvenile epiphysis was investigated to understand under which circumstances the blood vessels supplying the femoral epiphysis could become obstructed...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29616138/reviewer-acknowledgement
#11
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29363522/experimental-and-numerical-investigation-into-the-influence-of-loading-conditions-in-biomechanical-testing-of-locking-plate-fracture-fixation-devices
#12
A MacLeod, A H R W Simpson, P Pankaj
OBJECTIVES: Secondary fracture healing is strongly influenced by the stiffness of the bone-fixator system. Biomechanical tests are extensively used to investigate stiffness and strength of fixation devices. The stiffness values reported in the literature for locked plating, however, vary by three orders of magnitude. The aim of this study was to examine the influence that the method of restraint and load application has on the stiffness produced, the strain distribution within the bone, and the stresses in the implant for locking plate constructs...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29363521/the-effect-of-aminoguanidine-ag-and-pyridoxamine-pm-on-ageing-human-cortical-bone
#13
O Abar, S Dharmar, S Y Tang
OBJECTIVES: Advanced glycation end-products (AGEs) are a post-translational modification of collagen that form spontaneously in the skeletal matrix due to the presence of reducing sugars, such as glucose. The accumulation of AGEs leads to collagen cross-linking, which adversely affects bone quality and has been shown to play a major role in fracture risk. Thus, intervening in the formation and accumulation of AGEs may be a viable means of protecting bone quality. METHODS: An in vitro model was used to examine the efficacy of two AGE-inhibitors, aminoguanidine (AG) and pyridoxamine (PM), on ageing human cortical bone...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29363520/intraoperative-femoral-fractures-prevention-is-better-than-cure
#14
EDITORIAL
P S Young, S Patil, R M D Meek
No abstract text is available yet for this article.
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29363519/increased-sclerostin-associated-with-stress-fracture-of-the-third-metacarpal-bone-in-the-thoroughbred-racehorse
#15
N Hopper, E Singer, F Henson
OBJECTIVES: The exact aetiology and pathogenesis of microdamage-induced long bone fractures remain unknown. These fractures are likely to be the result of inadequate bone remodelling in response to damage. This study aims to identify an association of osteocyte apoptosis, the presence of osteocytic osteolysis, and any alterations in sclerostin expression with a fracture of the third metacarpal (Mc-III) bone of Thoroughbred racehorses. METHODS: A total of 30 Mc-III bones were obtained; ten bones were fractured during racing, ten were from the contralateral limb, and ten were from control horses...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29363518/serum-biomarkers-in-periprosthetic-joint-infections
#16
A Saleh, J George, M Faour, A K Klika, C A Higuera
OBJECTIVES: The diagnosis of periprosthetic joint infection (PJI) is difficult and requires a battery of tests and clinical findings. The purpose of this review is to summarize all current evidence for common and new serum biomarkers utilized in the diagnosis of PJI. METHODS: We searched two literature databases, using terms that encompass all hip and knee arthroplasty procedures, as well as PJI and statistical terms reflecting diagnostic parameters. The findings are summarized as a narrative review...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29330346/underestimation-of-staphylococcus-aureus-mrsa-and-mssa-carriage-associated-with-standard-culturing-techniques-one-third-of-carriers-missed
#17
S T J Tsang, M P McHugh, D Guerendiain, P J Gwynne, J Boyd, A H R W Simpson, T S Walsh, I F Laurenson, K E Templeton
OBJECTIVES: Nasal carriers of Staphylococcus (S.) aureus ( MRSA and MSSA ) have an increased risk for healthcare-associated infections. There are currently limited national screening policies for the detection of S. aureus despite the World Health Organization's recommendations. This study aimed to evaluate the diagnostic performance of molecular and culture techniques in S. aureus screening, determine the cause of any discrepancy between the diagnostic techniques, and model the potential effect of different diagnostic techniques on S...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29330345/a-computational-simulation-study-to-determine-the-biomechanical-influence-of-posterior-condylar-offset-and-tibial-slope-in-cruciate-retaining-total-knee-arthroplasty
#18
K-T Kang, Y-G Koh, J Son, O-R Kwon, J-S Lee, S K Kwon
OBJECTIVES: Posterior condylar offset (PCO) and posterior tibial slope (PTS) are critical factors in total knee arthroplasty (TKA). A computational simulation was performed to evaluate the biomechanical effect of PCO and PTS on cruciate retaining TKA. METHODS: We generated a subject-specific computational model followed by the development of ± 1 mm, ± 2 mm and ± 3 mm PCO models in the posterior direction, and -3°, 0°, 3° and 6° PTS models with each of the PCO models...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29330344/parathyroid-hormone-related-protein-exhibits-antioxidant-features-in-osteoblastic-cells-through-its-n-terminal-and-osteostatin-domains
#19
S Portal-Núñez, J A Ardura, D Lozano, I Martínez de Toda, M De la Fuente, G Herrero-Beaumont, R Largo, P Esbrit
OBJECTIVES: Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been shown to be associated with its ability to counteract oxidative stress in osteoblasts. The PTH counterpart in bone, which is the PTH-related protein (PTHrP), displays osteogenic actions through both its N-terminal PTH-like region and the C-terminal domain...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29330343/treatment-of-osteomyelitis-defects-by-a-vancomycin-loaded-gelatin-%C3%AE-tricalcium-phosphate-composite-scaffold
#20
J Zhou, X G Zhou, J W Wang, H Zhou, J Dong
OBJECTIVE: In the present study, we aimed to assess whether gelatin/β-tricalcium phosphate (β-TCP) composite porous scaffolds could be used as a local controlled release system for vancomycin. We also investigated the efficiency of the scaffolds in eliminating infections and repairing osteomyelitis defects in rabbits. METHODS: The gelatin scaffolds containing differing amounts of of β-TCP (0%, 10%, 30% and 50%) were prepared for controlled release of vancomycin and were labelled G-TCP0, G-TCP1, G-TCP3 and G-TCP5, respectively...
January 2018: Bone & Joint Research
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