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Bone & Joint Research

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https://www.readbyqxmd.com/read/29122748/infographic-acl-injury-reconstruction-and-recovery
#1
R M Queen
No abstract text is available yet for this article.
November 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29113973/maximising-the-impact-of-your-work-using-infographics
#2
EDITORIAL
I R Murray, A D Murray, S J Wordie, C W Oliver, A W Murray, A H R W Simpson
No abstract text is available yet for this article.
November 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29092816/dysregulation-of-both-mir-140-3p-and-mir-140-5p-in-synovial-fluid-correlate-with-osteoarthritis-severity
#3
C-M Yin, W-C-W Suen, S Lin, X-M Wu, G Li, X-H Pan
OBJECTIVES: This study looked to analyse the expression levels of microRNA-140-3p and microRNA-140-5p in synovial fluid, and their correlations to the severity of disease regarding knee osteoarthritis (OA). METHODS: Knee joint synovial fluid samples were collected from 45 patients with OA of the knee (15 mild, 15 moderate and 15 severe), ten healthy volunteers, ten patients with gouty arthritis, and ten with rheumatoid arthritis. The Kellgren-Lawrence grading (KLG) was used to assess the radiological severity of knee OA, and the patients were stratified into mild (KLG < 2), moderate (KLG = 2), and severe (KLG > 2)...
November 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29074602/the-forgotten-phase-of-fracture-healing-the-need-to-predict-nonunion
#4
EDITORIAL
A H R W Simpson
No abstract text is available yet for this article.
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29066534/the-effect-of-long-term-bisphosphonate-therapy-on-trabecular-bone-strength-and-microcrack-density
#5
A Jin, J Cobb, U Hansen, R Bhattacharya, C Reinhard, N Vo, R Atwood, J Li, A Karunaratne, C Wiles, R Abel
OBJECTIVES: Bisphosphonates (BP) are the first-line treatment for preventing fragility fractures. However, concern regarding their efficacy is growing because bisphosphonate is associated with over-suppression of remodelling and accumulation of microcracks. While dual-energy X-ray absorptiometry (DXA) scanning may show a gain in bone density, the impact of this class of drug on mechanical properties remains unclear. We therefore sought to quantify the mechanical strength of bone treated with BP (oral alendronate), and correlate data with the microarchitecture and density of microcracks in comparison with untreated controls...
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29066533/the-reporting-of-outcomes-in-randomised-controlled-trials-the-switch-and-the-spin
#6
EDITORIAL
M Ghert
No abstract text is available yet for this article.
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29066532/impact-of-the-profher-trial-findings-on-surgeons-clinical-practice-an-online-questionnaire-survey
#7
L Jefferson, S Brealey, H Handoll, A Keding, L Kottam, I Sbizzera, A Rangan
OBJECTIVES: To explore whether orthopaedic surgeons have adopted the Proximal Fracture of the Humerus: Evaluation by Randomisation (PROFHER) trial results routinely into clinical practice. METHODS: A questionnaire was piloted with six orthopaedic surgeons using a 'think aloud' process. The final questionnaire contained 29 items and was distributed online to surgeon members of the British Orthopaedic Association and British Elbow and Shoulder Society. Descriptive statistics summarised the sample characteristics and fracture treatment of respondents overall, and grouped them by whether they changed practice based on PROFHER trial findings...
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29054991/the-influence-of-bone-mineral-density-and-cortical-index-on-the-complexity-of-fractures-of-the-proximal-humerus
#8
J W A M den Teuling, B S Pauwels, L Janssen, C E Wyers, H M J Janzing, J P W van den Bergh, J W Morrenhof
OBJECTIVES: The goal of this study is to investigate the relation between indicators of osteoporosis (i.e., bone mineral density (BMD), and Cortical Index (CI)) and the complexity of a fracture of the proximal humerus as a result of a low-energy trauma. METHODS: A retrospective chart review of 168 patients (mean age 67.2 years, range 51 to 88.7) with a fracture of the proximal humerus between 2007 and 2011, whose BMD was assessed at the Fracture Liaison Service with Dual Energy X-ray Absorptiometry (DXA) measurements of the hip, femoral neck (FN) and/or lumbar spine (LS), and whose CI and complexity of fracture were assessed on plain anteroposterior radiographs of the proximal humerus...
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29054990/how-3d-patient-specific-instruments-improve-accuracy-of-pelvic-bone-tumour-resection-in-a-cadaveric-study
#9
A Sallent, M Vicente, M M Reverté, A Lopez, A Rodríguez-Baeza, M Pérez-Domínguez, R Velez
OBJECTIVES: To assess the accuracy of patient-specific instruments (PSIs) versus standard manual technique and the precision of computer-assisted planning and PSI-guided osteotomies in pelvic tumour resection. METHODS: CT scans were obtained from five female cadaveric pelvises. Five osteotomies were designed using Mimics software: sacroiliac, biplanar supra-acetabular, two parallel iliopubic and ischial. For cases of the left hemipelvis, PSIs were designed to guide standard oscillating saw osteotomies and later manufactured using 3D printing...
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28978616/integrative-analysis-of-gwas-eqtls-and-meqtls-data-suggests-that-multiple-gene-sets-are-associated-with-bone-mineral-density
#10
W Wang, S Huang, W Hou, Y Liu, Q Fan, A He, Y Wen, J Hao, X Guo, F Zhang
OBJECTIVES: Several genome-wide association studies (GWAS) of bone mineral density (BMD) have successfully identified multiple susceptibility genes, yet isolated susceptibility genes are often difficult to interpret biologically. The aim of this study was to unravel the genetic background of BMD at pathway level, by integrating BMD GWAS data with genome-wide expression quantitative trait loci (eQTLs) and methylation quantitative trait loci (meQTLs) data METHOD: We employed the GWAS datasets of BMD from the Genetic Factors for Osteoporosis Consortium (GEFOS), analysing patients' BMD...
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28963103/the-role-of-routine-screening-in-blood-borne-pathogens-in-chinese-patients-undergoing-joint-arthroplasty
#11
T Cheng, X-L Zhang, J-J Hu, B Li, Q Wang
OBJECTIVES: Surgeons face a substantial risk of infection because of the occupational exposure to blood-borne pathogens (BBPs) from patients undergoing high-risk orthopaedic procedures. This study aimed to determine the seroprevalence of four BBPs among patients undergoing joint arthroplasty in Shanghai, China. In addition, we evaluated the significance of pre-operative screening by calculating a cost-to-benefit ratio. METHODS: A retrospective observational study of pre-operative screening for BBPs, including hepatitis B and C viruses (HBV and HCV), human immunodeficiency virus (HIV) and Treponema pallidum (TP), was conducted for sequential patients in the orthopaedic department of a large urban teaching hospital between 01 January 2009 and 30 May 2016...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28947604/preservation-of-kinematics-with-posterior-cruciate-bicruciate-and-patient-specific-bicruciate-retaining-prostheses-in-total-knee-arthroplasty-by-using-computational-simulation-with-normal-knee-model
#12
Y-G Koh, J Son, S-K Kwon, H-J Kim, O-R Kwon, K-T Kang
OBJECTIVES: Preservation of both anterior and posterior cruciate ligaments in total knee arthroplasty (TKA) can lead to near-normal post-operative joint mechanics and improved knee function. We hypothesised that a patient-specific bicruciate-retaining prosthesis preserves near-normal kinematics better than standard off-the-shelf posterior cruciate-retaining and bicruciate-retaining prostheses in TKA. METHODS: We developed the validated models to evaluate the post-operative kinematics in patient-specific bicruciate-retaining, standard off-the-shelf bicruciate-retaining and posterior cruciate-retaining TKA under gait and deep knee bend loading conditions using numerical simulation...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28947603/predicting-30-day-mortality-after-hip-fracture-surgery-evaluation-of-the-national-hip-fracture-database-case-mix-adjustment-model
#13
C Tsang, C Boulton, V Burgon, A Johansen, R Wakeman, D A Cromwell
OBJECTIVES: The National Hip Fracture Database (NHFD) publishes hospital-level risk-adjusted mortality rates following hip fracture surgery in England, Wales and Northern Ireland. The performance of the risk model used by the NHFD was compared with the widely-used Nottingham Hip Fracture Score. METHODS: Data from 94 hospitals on patients aged 60 to 110 who had hip fracture surgery between May 2013 and July 2013 were analysed. Data were linked to the Office for National Statistics (ONS) death register to calculate the 30-day mortality rate...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28924020/microindentation-a-tool-for-measuring-cortical-bone-stiffness-a-systematic-review
#14
M Arnold, S Zhao, S Ma, F Giuliani, U Hansen, J P Cobb, R L Abel, O Boughton
OBJECTIVES: Microindentation has the potential to measure the stiffness of an individual patient's bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. The question addressed with this systematic review is whether microindentation can accurately measure cortical bone stiffness. METHODS: A systematic review of all English language articles using a keyword search was undertaken using Medline, Embase, PubMed, Scopus and Cochrane databases...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28899856/release-of-the-tourniquet-immediately-after-the-implantation-of-the-components-reduces-the-incidence-of-deep-vein-thrombosis-after-primary-total-knee-arthroplasty
#15
P Zan, M O Mol, J J Yao, L Fan, D Yang, K Liu, G Li
AIMS: The length of the tourniquet time during total knee arthroplasty (TKA) is related to the incidence of post-operative deep vein thrombosis (DVT). Our aim in this study was to investigate the effect of the early release of the tourniquet on the incidence of DVT in patients undergoing TKA. METHODS: A total of 200 patients who underwent TKA between November 2015 and November 2016 were prospectively enrolled. The tourniquet was inflated before surgery and released immediately after the introduction of the components (early release group)...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28899855/a-simple-method-of-measuring-the-wear-of-explanted-acetabular-component-inserts
#16
L Krakow, A Klockow, E Roehner, S Brodt, H Eijer, J Bossert, G Matziolis
AIMS: The determination of the volumetric polyethylene wear on explanted material requires complicated equipment, which is not available in many research institutions. Our aim in this study was to present and validate a method that only requires a set of polyetheretherketone balls and a laboratory balance to determine wear. METHODS: The insert to be measured was placed on a balance, and a ball of the appropriate diameter was inserted. The cavity remaining between the ball and insert caused by wear was filled with contrast medium and the weight of the contrast medium was recorded...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28855192/the-effect-of-implant-position-on-bone-strain-following-lateral-unicompartmental-knee-arthroplasty-a-biomechanical-model-using-digital-image-correlation
#17
A M Ali, S D S Newman, P A Hooper, C M Davies, J P Cobb
OBJECTIVES: Unicompartmental knee arthroplasty (UKA) is a demanding procedure, with tibial component subsidence or pain from high tibial strain being potential causes of revision. The optimal position in terms of load transfer has not been documented for lateral UKA. Our aim was to determine the effect of tibial component position on proximal tibial strain. METHODS: A total of 16 composite tibias were implanted with an Oxford Domed Lateral Partial Knee implant using cutting guides to define tibial slope and resection depth...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28855191/three-dimensional-knee-kinematic-analysis-during-treadmill-gait-slow-imposed-speed-versus-normal-self-selected-speed
#18
N Mannering, T Young, T Spelman, P F Choong
OBJECTIVES: Whilst gait speed is variable between healthy and injured adults, the extent to which speed alone alters the 3D in vivo knee kinematics has not been fully described. The purpose of this prospective study was to understand better the spatiotemporal and 3D knee kinematic changes induced by slow compared with normal self-selected walking speeds within young healthy adults. METHODS: A total of 26 men and 25 women (18 to 35 years old) participated in this study...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28851695/thompson-hemiarthroplasty-versus-modular-unipolar-implants-for-patients-requiring-hemiarthroplasty-of-the-hip-a-systematic-review-of-the-evidence
#19
A L Sims, A J Farrier, M R Reed, T A Sheldon
OBJECTIVES: The objective of this study was to assess all evidence comparing the Thompson monoblock hemiarthroplasty with modular unipolar implants for patients requiring hemiarthroplasty of the hip with respect to mortality and complications. METHODS: A literature search was performed to identify all relevant literature. The population consisted of patients undergoing hemiarthroplasty of the hip for fracture. The intervention was hemiarthroplasty of the hip with a comparison between Thompson and modular unipolar prostheses...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28851694/dose-optimisation-of-intravenous-tranexamic-acid-for-elective-hip-and-knee-arthroplasty-the-effectiveness-of-a-single-pre-operative-dose
#20
R J M Morrison, B Tsang, W Fishley, I Harper, J C Joseph, M R Reed
OBJECTIVES: We have increased the dose of tranexamic acid (TXA) in our enhanced total joint recovery protocol at our institution from 15 mg/kg to 30 mg/kg (maximum 2.5 g) as a single, intravenous (IV) dose. We report the clinical effect of this dosage change. METHODS: We retrospectively compared two cohorts of consecutive patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) surgery in our unit between 2008 and 2013. One group received IV TXA 15 mg/kg, maximum 1...
August 2017: Bone & Joint Research
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