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Bone & Joint Research

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https://www.readbyqxmd.com/read/28420623/externalised-locking-compression-plate-as-an-alternative-to-the-unilateral-external-fixator-a-biomechanical-comparative-study-of-axial-and-torsional-stiffness
#1
B F H Ang, J Y Chen, A K S Yew, S K Chua, S M Chou, S L Chia, J S B Koh, T S Howe
OBJECTIVES: External fixators are the traditional fixation method of choice for contaminated open fractures. However, patient acceptance is low due to the high profile and therefore physical burden of the constructs. An externalised locking compression plate is a low profile alternative. However, the biomechanical differences have not been assessed. The objective of this study was to evaluate the axial and torsional stiffness of the externalised titanium locking compression plate (ET-LCP), the externalised stainless steel locking compression plate (ESS-LCP) and the unilateral external fixator (UEF)...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28408376/a-comparative-study-of-tissue-engineered-constructs-from-acropora-and-porites-coral-in-a-large-animal-bone-defect-model
#2
A Decambron, M Manassero, M Bensidhoum, B Lecuelle, D Logeart-Avramoglou, H Petite, V Viateau
OBJECTIVES: To compare the therapeutic potential of tissue-engineered constructs (TECs) combining mesenchymal stem cells (MSCs) and coral granules from either Acropora or Porites to repair large bone defects. MATERIALS AND METHODS: Bone marrow-derived, autologous MSCs were seeded on Acropora or Porites coral granules in a perfusion bioreactor. Acropora-TECs (n = 7), Porites-TECs (n = 6) and bone autografts (n = 2) were then implanted into 25 mm long metatarsal diaphyseal defects in sheep...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28404548/the-tip-apex-distance-in-the-x-bolt-dynamic-plating-system
#3
M A Fernandez, A Aquilina, J Achten, N Parsons, M L Costa, X L Griffin
OBJECTIVES: The Sliding Hip Screw (SHS) is commonly used to treat trochanteric hip fractures. Fixation failure is a devastating complication requiring complex revision surgery. One mode of fixation failure is lag screw cut-out which is greatest in unstable fracture patterns and when the tip-apex distance of the lag screw is > 25 mm. The X-Bolt Dynamic Hip Plating System (X-Bolt Orthopaedics, Dublin, Ireland) is a new device which aims to reduce this risk of cut-out. However, some surgeons have reported difficulty minimising the tip-apex distance with subsequent concerns that this may lead to an increased risk of cut-out...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28404547/the-role-of-mir-320a-and-il-1%C3%AE-in-human-chondrocyte-degradation
#4
Y Jin, X Chen, Z Y Gao, K Liu, Y Hou, J Zheng
OBJECTIVES: This study aimed to explore the role of miR-320a in the pathogenesis of osteoarthritis (OA). METHODS: Human cartilage cells (C28/I2) were transfected with miR-320a or antisense oligonucleotides (ASO)-miR-320a, and treated with IL-1β. Subsequently the expression of collagen type II alpha 1 (Col2α1) and aggrecan (ACAN), and the concentrations of sulfated glycosaminoglycans (sGAG) and matrix metallopeptidase 13 (MMP-13), were assessed. Luciferase reporter assay, qRT-PCR, and Western blot were performed to explore whether pre-B-cell leukemia Homeobox 3 (PBX3) was a target of miR-320a...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28377379/surgical-trial-design-learning-curve-and-surgeon-volume-determining-whether-inferior-results-are-due-to-the-procedure-itself-or-delivery-of-the-procedure-by-the-surgeon
#5
EDITORIAL
A H R W Simpson, C R Howie, J Norrie
No abstract text is available yet for this article.
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28360085/silencing-of-translation-initiation-factor-eif3b-promotes-apoptosis-in-osteosarcoma-cells
#6
Y J Choi, Y S Lee, H W Lee, D M Shim, S W Seo
OBJECTIVES: Eukaryotic translation initiation factor 3 (eIF3) is a multi-subunit complex that plays a critical role in translation initiation. Expression levels of eIF3 subunits are elevated or decreased in various cancers, suggesting a role for eIF3 in tumorigenesis. Recent studies have shown that the expression of the eIF3b subunit is elevated in bladder and prostate cancer, and eIF3b silencing inhibited glioblastoma growth and induced cellular apoptosis. In this study, we investigated the role of eIF3b in the survival of osteosarcoma cells...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28360084/the-revitalisation-of-flexor-tendon-allografts-with-bone-marrow-stromal-cells-and-mechanical-stimulation-an-ex-vivo-model-revitalising-flexor-tendon-allografts
#7
J H Wu, A R Thoreson, A Gingery, K N An, S L Moran, P C Amadio, C Zhao
OBJECTIVES: The present study describes a novel technique for revitalising allogenic intrasynovial tendons by combining cell-based therapy and mechanical stimulation in an ex vivo canine model. METHODS: Specifically, canine flexor digitorum profundus tendons were used for this study and were divided into the following groups: (1) untreated, unprocessed normal tendon; (2) decellularised tendon; (3) bone marrow stromal cell (BMSC)-seeded tendon; and (4) BMSC-seeded and cyclically stretched tendon...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28360083/posterior-condylar-offset-is-an-independent-predictor-of-functional-outcome-after-revision-total-knee-arthroplasty
#8
N D Clement, D J MacDonald, D F Hamilton, R Burnett
OBJECTIVES: Preservation of posterior condylar offset (PCO) has been shown to correlate with improved functional results after primary total knee arthroplasty (TKA). Whether this is also the case for revision TKA, remains unknown. The aim of this study was to assess the independent effect of PCO on early functional outcome after revision TKA. METHODS: A total of 107 consecutive aseptic revision TKAs were performed by a single surgeon during an eight-year period...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28347978/intra-articular-implantation-of-collagen-scaffold-carriers-is-safe-in-both-native-and-arthrofibrotic-rabbit-knee-joints
#9
J A Walker, T J Ewald, E Lewallen, A Van Wijnen, A D Hanssen, B F Morrey, M E Morrey, M P Abdel, J Sanchez-Sotelo
OBJECTIVES: Sustained intra-articular delivery of pharmacological agents is an attractive modality but requires use of a safe carrier that would not induce cartilage damage or fibrosis. Collagen scaffolds are widely available and could be used intra-articularly, but no investigation has looked at the safety of collagen scaffolds within synovial joints. The aim of this study was to determine the safety of collagen scaffold implantation in a validated in vivo animal model of knee arthrofibrosis...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28298321/ubiquitin-e3-ligase-itch-negatively-regulates-osteoblast-function-by-promoting-proteasome-degradation-of-osteogenic-proteins
#10
J Liu, X Li, H Zhang, R Gu, Z Wang, Z Gao, L Xing
OBJECTIVES: Ubiquitin E3 ligase-mediated protein degradation regulates osteoblast function. Itch, an E3 ligase, affects numerous cell functions by regulating ubiquitination and proteasomal degradation of related proteins. However, the Itch-related cellular and molecular mechanisms by which osteoblast differentiation and function are elevated during bone fracture repair are as yet unknown. METHODS: We examined the expression levels of E3 ligases and NF-κB members in callus samples during bone fracture repair by quantitative polymerase chain reaction (qPCR) and the total amount of ubiquitinated proteins by Western blot analysis in wild-type (WT) mice...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28288986/bisphosphonates-and-atypical-subtrochanteric-fractures-of-the-femur
#11
N Kharwadkar, B Mayne, J E Lawrence, V Khanduja
OBJECTIVES: Bisphosphonates are widely used as first-line treatment for primary and secondary prevention of fragility fractures. Whilst they have proved effective in this role, there is growing concern over their long-term use, with much evidence linking bisphosphonate-related suppression of bone remodelling to an increased risk of atypical subtrochanteric fractures of the femur (AFFs). The objective of this article is to review this evidence, while presenting the current available strategies for the management of AFFs...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28258117/augmented-reality-in-bone-tumour-resection-an-experimental-study
#12
H S Cho, Y K Park, S Gupta, C Yoon, I Han, H-S Kim, H Choi, J Hong
OBJECTIVES: We evaluated the accuracy of augmented reality (AR)-based navigation assistance through simulation of bone tumours in a pig femur model. METHODS: We developed an AR-based navigation system for bone tumour resection, which could be used on a tablet PC. To simulate a bone tumour in the pig femur, a cortical window was made in the diaphysis and bone cement was inserted. A total of 133 pig femurs were used and tumour resection was simulated with AR-assisted resection (164 resection in 82 femurs, half by an orthropaedic oncology expert and half by an orthopaedic resident) and resection with the conventional method (82 resection in 41 femurs)...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28258116/inhibitory-effects-of-vancomycin-and-fosfomycin-on-methicillin-resistant-staphylococcus-aureus-from-antibiotic-impregnated-articulating-cement-spacers
#13
V Yuenyongviwat, N Ingviya, P Pathaburee, B Tangtrakulwanich
OBJECTIVES: Vancomycin and fosfomycin are antibiotics commonly used to treat methicillin-resistant Staphylococcus aureus (MRSA) infection. This study compares the in vitro inhibitory effects against MRSA of articulating cement spacers impregnated with either vancomycin or fosfomycin. METHODS: Vancomycin-impregnated articulating cement spacers and fosfomycin-impregnated articulating cement spacers were immersed in sterile phosphate-buffered saline (PBS) solutions and then incubated...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28258115/the-effect-of-systemic-administration-of-g-csf-on-a-full-thickness-cartilage-defect-in-a-rabbit-model-msc-proliferation-as-presumed-mechanism-g-csf-for-cartilage-repair
#14
T Sasaki, R Akagi, Y Akatsu, T Fukawa, H Hoshi, Y Yamamoto, T Enomoto, Y Sato, R Nakagawa, K Takahashi, S Yamaguchi, T Sasho
OBJECTIVES: The aim of this study was to investigate the effect of granulocyte-colony stimulating factor (G-CSF) on mesenchymal stem cell (MSC) proliferation in vitro and to determine whether pre-microfracture systemic administration of G-CSF (a bone marrow stimulant) could improve the quality of repaired tissue of a full-thickness cartilage defect in a rabbit model. METHODS: MSCs from rabbits were cultured in a control medium and medium with G-CSF (low-dose: 4 μg, high-dose: 40 μg)...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28246095/explant-analysis-of-the-biomet-magnum-recap-metal-on-metal-hip-joint
#15
S C Scholes, B J Hunt, V M Richardson, D J Langton, E Smith, T J Joyce
OBJECTIVES: The high revision rates of the DePuy Articular Surface Replacement (ASR) and the DePuy ASR XL (the total hip arthroplasty (THA) version) have led to questions over the viability of metal-on-metal (MoM) hip joints. Some designs of MoM hip joint do, however, have reasonable mid-term performance when implanted in appropriate patients. Investigations into the reasons for implant failure are important to offer help with the choice of implants and direction for future implant designs...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28246094/bactericidal-and-antimicrobial-effects-of-pure-titanium-and-titanium-alloy-treated-with-short-term-low-energy-uv-irradiation
#16
T Itabashi, K Narita, A Ono, K Wada, T Tanaka, G Kumagai, R Yamauchi, A Nakane, Y Ishibashi
OBJECTIVES: The surface of pure titanium (Ti) shows decreased histocompatibility over time; this phenomenon is known as biological ageing. UV irradiation enables the reversal of biological ageing through photofunctionalisation, a physicochemical alteration of the titanium surface. Ti implants are sterilised by UV irradiation in dental surgery. However, orthopaedic biomaterials are usually composed of the alloy Ti6Al4V, for which the antibacterial effects of UV irradiation are unconfirmed...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28235767/canine-articular-cartilage-regeneration-using-mesenchymal-stem-cells-seeded-on-platelet-rich-fibrin-macroscopic-and-histological-assessments
#17
D Kazemi, K Shams Asenjan, N Dehdilani, H Parsa
OBJECTIVES: Mesenchymal stem cells have the ability to differentiate into various cell types, and thus have emerged as promising alternatives to chondrocytes in cell-based cartilage repair methods. The aim of this experimental study was to investigate the effect of bone marrow derived mesenchymal stem cells combined with platelet rich fibrin on osteochondral defect repair and articular cartilage regeneration in a canine model. METHODS: Osteochondral defects were created on the medial femoral condyles of 12 adult male mixed breed dogs...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28188129/enhancement-of-fracture-healing-in-the-rat-modulated-by-compounds-that-stimulate-inducible-nitric-oxide-synthase-acceleration-of-fracture-healing-via-inducible-nitric-oxide-synthase
#18
R A Rajfer, A Kilic, A S Neviaser, L M Schulte, S M Hlaing, J Landeros, M G Ferrini, E Ebramzadeh, S-H Park
OBJECTIVES: We investigated the effects on fracture healing of two up-regulators of inducible nitric oxide synthase (iNOS) in a rat model of an open femoral osteotomy: tadalafil, a phosphodiesterase inhibitor, and the recently reported nutraceutical, COMB-4 (consisting of L-citrulline, Paullinia cupana, ginger and muira puama), given orally for either 14 or 42 days. MATERIALS AND METHODS: Unilateral femoral osteotomies were created in 58 male rats and fixed with an intramedullary compression nail...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28167489/mechanical-properties-of-all-suture-anchors-for-rotator-cuff-repair
#19
N S Nagra, N Zargar, R D J Smith, A J Carr
OBJECTIVES: All-suture anchors are increasingly used in rotator cuff repair procedures. Potential benefits include decreased bone damage. However, there is limited published evidence for the relative strength of fixation for all-suture anchors compared with traditional anchors. MATERIALS AND METHODS: A total of four commercially available all-suture anchors, the 'Y-Knot' (ConMed), Q-FIX (Smith & Nephew), ICONIX (Stryker) and JuggerKnot (Zimmer Biomet) and a traditional anchor control TWINFIX Ultra PK Suture Anchor (Smith & Nephew) were tested in cadaveric human humeral head rotator cuff repair models (n = 24)...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28148490/characterisation-of-osteophytes-as-an-autologous-bone-graft-source-an-experimental-study-in-vivo-and-in-vitro
#20
K Ishihara, K Okazaki, T Akiyama, Y Akasaki, Y Nakashima
OBJECTIVES: Osteophytes are products of active endochondral and intramembranous ossification, and therefore could theoretically provide significant efficacy as bone grafts. In this study, we compared the bone mineralisation effectiveness of osteophytes and cancellous bone, including their effects on secretion of growth factors and anabolic effects on osteoblasts. METHODS: Osteophytes and cancellous bone obtained from human patients were transplanted onto the calvaria of severe combined immunodeficient mice, with Calcein administered intra-peritoneally for fluorescent labelling of bone mineralisation...
February 2017: Bone & Joint Research
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