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Bone & Joint Research

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https://www.readbyqxmd.com/read/28108483/measuring-hip-muscle-strength-in-patients-with-femoroacetabular-impingement-and-other-hip-pathologies-a-systematic-review
#1
E Mayne, A Memarzadeh, P Raut, A Arora, V Khanduja
OBJECTIVES: The aim of this study was to systematically review the literature on measurement of muscle strength in patients with femoroacetabular impingement (FAI) and other pathologies and to suggest guidelines to standardise protocols for future research in the field. METHODS: The Cochrane and PubMed libraries were searched for any publications using the terms 'hip', 'muscle', 'strength', and 'measurement' in the 'Title, Abstract, Keywords' field. A further search was performed using the terms 'femoroacetabular' or 'impingement'...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28108482/inhibition-of-prolyl-4-hydroxylase-decreases-muscle-fibrosis-following-chronic-rotator-cuff-tear
#2
J P Gumucio, M D Flood, A Bedi, H F Kramer, A J Russell, C L Mendias
OBJECTIVES: Rotator cuff tears are among the most frequent upper extremity injuries. Current treatment strategies do not address the poor quality of the muscle and tendon following chronic rotator cuff tears. Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that activates many genes that are important in skeletal muscle regeneration. HIF-1α is inhibited under normal physiological conditions by the HIF prolyl 4-hydroxylases (PHDs). In this study, we used a pharmacological PHD inhibitor, GSK1120360A, to enhance the activity of HIF-1α following the repair of a chronic cuff tear, and measured muscle fibre contractility, fibrosis, gene expression, and enthesis mechanics...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28108481/clinically-insignificant-trunnionosis-in-large-diameter-metal-on-polyethylene-total-hip-arthroplasty
#3
H S Hothi, D Kendoff, C Lausmann, J Henckel, T Gehrke, J Skinner, A Hart
OBJECTIVES: Mechanical wear and corrosion at the head-stem junction of total hip arthroplasties (THAs) (trunnionosis) have been implicated in their early revision, most commonly in metal-on-metal (MOM) hips. We can isolate the role of the head-stem junction as the predominant source of metal release by investigating non-MOM hips; this can help to identify clinically significant volumes of material loss and corrosion from these surfaces. METHODS: In this study we examined a series of 94 retrieved metal-on-polyethylene (MOP) hips for evidence of corrosion and material loss at the taper junction using a well published visual grading method and an established roundness-measuring machine protocol...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28077396/the-effects-of-kinematically-aligned-total-knee-arthroplasty-on-stress-at-the-medial-tibia-a-case-study-for-varus-knee
#4
S Nakamura, Y Tian, Y Tanaka, S Kuriyama, H Ito, M Furu, S Matsuda
OBJECTIVES: Little biomechanical information is available about kinematically aligned (KA) total knee arthroplasty (TKA). The purpose of this study was to simulate the kinematics and kinetics after KA TKA and mechanically aligned (MA) TKA with four different limb alignments. MATERIALS AND METHODS: Bone models were constructed from one volunteer (normal) and three patients with three different knee deformities (slight, moderate and severe varus). A dynamic musculoskeletal modelling system was used to analyse the kinematics and the tibiofemoral contact force...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28077395/the-effects-of-posterior-cruciate-ligament-deficiency-on-posterolateral-corner-structures-under-gait-and-squat-loading-conditions-a-computational-knee-model
#5
K-T Kang, Y-G Koh, M Jung, J-H Nam, J Son, Y H Lee, S-J Kim, S-H Kim
OBJECTIVES: The aim of the current study was to analyse the effects of posterior cruciate ligament (PCL) deficiency on forces of the posterolateral corner structure and on tibiofemoral (TF) and patellofemoral (PF) contact force under dynamic-loading conditions. METHODS: A subject-specific knee model was validated using a passive flexion experiment, electromyography data, muscle activation, and previous experimental studies. The simulation was performed on the musculoskeletal models with and without PCL deficiency using a novel force-dependent kinematics method under gait- and squat-loading conditions, followed by probabilistic analysis for material uncertain to be considered...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28077394/metal-backed-versus-all-polyethylene-unicompartmental-knee-arthroplasty-proximal-tibial-strain-in-an-experimentally-validated-finite-element-model
#6
C E H Scott, M J Eaton, R W Nutton, F A Wade, S L Evans, P Pankaj
OBJECTIVES: Up to 40% of unicompartmental knee arthroplasty (UKA) revisions are performed for unexplained pain which may be caused by elevated proximal tibial bone strain. This study investigates the effect of tibial component metal backing and polyethylene thickness on bone strain in a cemented fixed-bearing medial UKA using a finite element model (FEM) validated experimentally by digital image correlation (DIC) and acoustic emission (AE). MATERIALS AND METHODS: A total of ten composite tibias implanted with all-polyethylene (AP) and metal-backed (MB) tibial components were loaded to 2500 N...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28062525/parathyroid-hormone-1-34-and-skeletal-anabolic-action-the-use-of-parathyroid-hormone-in-bone-formation
#7
L Osagie-Clouard, A Sanghani, M Coathup, T Briggs, M Bostrom, G Blunn
: Intermittently administered parathyroid hormone (PTH 1-34) has been shown to promote bone formation in both human and animal studies. The hormone and its analogues stimulate both bone formation and resorption, and as such at low doses are now in clinical use for the treatment of severe osteoporosis. By varying the duration of exposure, parathyroid hormone can modulate genes leading to increased bone formation within a so-called 'anabolic window'. The osteogenic mechanisms involved are multiple, affecting the stimulation of osteoprogenitor cells, osteoblasts, osteocytes and the stem cell niche, and ultimately leading to increased osteoblast activation, reduced osteoblast apoptosis, upregulation of Wnt/β-catenin signalling, increased stem cell mobilisation, and mediation of the RANKL/OPG pathway...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28057632/are-two-retrograde-3-5-mm-screws-superior-to-one-7-3-mm-screw-for-anterior-pelvic-ring-fixation-in-bones-with-low-bone-mineral-density
#8
Y P Acklin, I Zderic, S Grechenig, R G Richards, P Schmitz, B Gueorguiev
OBJECTIVES: Osteosynthesis of anterior pubic ramus fractures using one large-diameter screw can be challenging in terms of both surgical procedure and fixation stability. Small-fragment screws have the advantage of following the pelvic cortex and being more flexible.The aim of the present study was to biomechanically compare retrograde intramedullary fixation of the superior pubic ramus using either one large- or two small-diameter screws. MATERIALS AND METHODS: A total of 12 human cadaveric hemipelvises were analysed in a matched pair study design...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28057631/ultimate-fracture-load-of-cadaver-proximal-humeri-correlates-more-strongly-with-mean-combined-cortical-thickness-than-with-areal-cortical-index-dexa-density-or-canal-to-calcar-ratio
#9
J G Skedros, C S Mears, W Z Burkhead
OBJECTIVES: This investigation sought to advance the work published in our prior biomechanical study (Journal of Orthopaedic Research, 2016). We specifically sought to determine whether there are additional easy-to-measure parameters on plain radiographs of the proximal humerus that correlate more strongly with ultimate fracture load, and whether a parameter resembling the Dorr strength/quality characterisation of proximal femurs can be applied to humeri. MATERIALS AND METHODS: A total of 33 adult humeri were used from a previous study where we quantified bone mineral density of the proximal humerus using radiographs and dual-energy x-ray absorptiometry (DEXA), and regional mean cortical thickness and cortical index using radiographs...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/27965220/the-use-of-rats-and-mice-as-animal-models-in-ex-vivo-bone-growth-and-development-studies
#10
A A Abubakar, M M Noordin, T I Azmi, U Kaka, M Y Loqman
In vivo animal experimentation has been one of the cornerstones of biological and biomedical research, particularly in the field of clinical medicine and pharmaceuticals. The conventional in vivo model system is invariably associated with high production costs and strict ethical considerations. These limitations led to the evolution of an ex vivo model system which partially or completely surmounted some of the constraints faced in an in vivo model system. The ex vivo rodent bone culture system has been used to elucidate the understanding of skeletal physiology and pathophysiology for more than 90 years...
December 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27965219/effects-of-platelet-rich-plasma-and-triamcinolone-acetonide-on-interleukin-1%C3%A3-stimulated-human-rotator-cuff-derived-cells
#11
T Muto, T Kokubu, Y Mifune, A Inui, R Sakata, Y Harada, F Takase, M Kurosaka
OBJECTIVES: Triamcinolone acetonide (TA) is widely used for the treatment of rotator cuff injury because of its anti-inflammatory properties. However, TA can also produce deleterious effects such as tendon degeneration or rupture. These harmful effects could be prevented by the addition of platelet-rich plasma (PRP), however, the anti-inflammatory and anti-degenerative effects of the combined use of TA and PRP have not yet been made clear. The objective of this study was to determine how the combination of TA and PRP might influence the inflammation and degeneration of the rotator cuff by examining rotator cuff-derived cells induced by interleukin (IL)-1ß...
December 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27908864/identification-of-candidate-genes-in-osteoporosis-by-integrated-microarray-analysis
#12
J J Li, B Q Wang, Q Fei, Y Yang, D Li
OBJECTIVES: In order to screen the altered gene expression profile in peripheral blood mononuclear cells of patients with osteoporosis, we performed an integrated analysis of the online microarray studies of osteoporosis. METHODS: We searched the Gene Expression Omnibus (GEO) database for microarray studies of peripheral blood mononuclear cells in patients with osteoporosis. Subsequently, we integrated gene expression data sets from multiple microarray studies to obtain differentially expressed genes (DEGs) between patients with osteoporosis and normal controls...
December 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/28094763/measuring-the-effect-of-femoral-malrotation-on-knee-joint-biomechanics-for-total-knee-arthroplasty-using-computational-simulation
#13
K-T Kang, Y-G Koh, J Son, O-R Kwon, C Baek, S H Jung, K K Park
OBJECTIVES: Malrotation of the femoral component can result in post-operative complications in total knee arthroplasty (TKA), including patellar maltracking. Therefore, we used computational simulation to investigate the influence of femoral malrotation on contact stresses on the polyethylene (PE) insert and on the patellar button as well as on the forces on the collateral ligaments. MATERIALS AND METHODS: Validated finite element (FE) models, for internal and external malrotations from 0° to 10° with regard to the neutral position, were developed to evaluate the effect of malrotation on the femoral component in TKA...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27903506/is-the-hip-capsule-thicker-in-diseased-hips
#14
K S Rakhra, A A Bonura, R Nairn, M E Schweitzer, N M Kolanko, P E Beaule
OBJECTIVES: The purpose of this study was to compare the thickness of the hip capsule in patients with surgical hip disease, either with cam-femoroacetabular impingement (FAI) or non-FAI hip pathology, with that of asymptomatic control hips. METHODS: A total of 56 hips in 55 patients underwent a 3Tesla MRI of the hip. These included 40 patients with 41 hips with arthroscopically proven hip disease (16 with cam-FAI; nine men, seven women; mean age 39 years, 22 to 58) and 25 with non-FAI chondrolabral pathology (four men, 21 women; mean age 40 years, 18 to 63) as well as 15 asymptomatic volunteers, whose hips served as controls (ten men, five women; mean age 62 years, 33 to 77)...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27881441/evaluation-of-the-histological-and-mechanical-features-of-tendon-healing-in-a-rabbit-model-with-the-use-of-second-harmonic-generation-imaging-and-tensile-testing
#15
E Hase, K Sato, D Yonekura, T Minamikawa, M Takahashi, T Yasui
OBJECTIVES: This study aimed to evaluate the histological and mechanical features of tendon healing in a rabbit model with second-harmonic-generation (SHG) imaging and tensile testing. MATERIALS AND METHODS: A total of eight male Japanese white rabbits were used for this study. The flexor digitorum tendons in their right leg were sharply transected, and then were repaired by intratendinous stitching. At four weeks post-operatively, the rabbits were killed and the flexor digitorum tendons in both right and left legs were excised and used as specimens for tendon healing (n = 8) and control (n = 8), respectively...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27881440/culturing-bone-marrow-cells-with-dexamethasone-and-ascorbic-acid-improves-osteogenic-cell-sheet-structure
#16
M Akahane, T Shimizu, T Kira, T Onishi, Y Uchihara, T Imamura, Y Tanaka
OBJECTIVES: To assess the structure and extracellular matrix molecule expression of osteogenic cell sheets created via culture in medium with both dexamethasone (Dex) and ascorbic acid phosphate (AscP) compared either Dex or AscP alone. METHODS: Osteogenic cell sheets were prepared by culturing rat bone marrow stromal cells in a minimal essential medium (MEM), MEM with AscP, MEM with Dex, and MEM with Dex and AscP (Dex/AscP). The cell number and messenger (m)RNA expression were assessed in vitro, and the appearance of the cell sheets was observed after mechanical retrieval using a scraper...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27881439/optimisation-of-high-quality-total-ribonucleic-acid-isolation-from-cartilaginous-tissues-for-real-time-polymerase-chain-reaction-analysis
#17
M Peeters, C L Huang, L A Vonk, Z F Lu, R A Bank, M N Helder, B Zandieh Doulabi
OBJECTIVES: Studies which consider the molecular mechanisms of degeneration and regeneration of cartilaginous tissues are seriously hampered by problematic ribonucleic acid (RNA) isolations due to low cell density and the dense, proteoglycan-rich extracellular matrix of cartilage. Proteoglycans tend to co-purify with RNA, they can absorb the full spectrum of UV light and they are potent inhibitors of polymerase chain reaction (PCR). Therefore, the objective of the present study is to compare and optimise different homogenisation methods and RNA isolation kits for an array of cartilaginous tissues...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27831489/increased-sagittal-vertical-axis-is-associated-with-less-effective-control-of-acute-pain-following-vertebroplasty
#18
Y-C Kim, D H Bok, H-G Chang, S W Kim, M S Park, J K Oh, J Kim, T-H Kim
OBJECTIVES: Although vertebroplasty is very effective for relieving acute pain from an osteoporotic vertebral compression fracture, not all patients who undergo vertebroplasty receive the same degree of benefit from the procedure. In order to identify the ideal candidate for vertebroplasty, pre-operative prognostic demographic or clinico-radiological factors need to be identified. The objective of this study was to identify the pre-operative prognostic factors related to the effect of vertebroplasty on acute pain control using a cohort of surgically and non-surgically managed patients...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27827803/is-calcaneal-broadband-ultrasound-attenuation-a-valid-index-of-dual-energy-x-ray-absorptiometry-derived-bone-mass-in-children
#19
B K Weeks, R Hirsch, R C Nogueira, B R Beck
OBJECTIVES: The aim of the current study was to assess whether calcaneal broadband ultrasound attenuation (BUA) can predict whole body and regional dual-energy x-ray absorptiometry (DXA)-derived bone mass in healthy, Australian children and adolescents at different stages of maturity. METHODS: A total of 389 boys and girls across a wide age range (four to 18 years) volunteered to participate. The estimated age of peak height velocity (APHV) was used to classify children into pre-, peri-, and post-APHV groups...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27811144/the-damping-effect-of-cement-as-a-potential-mitigation-factor-of-squeaking-in-ceramic-on-ceramic-total-hip-arthroplasty
#20
F J Burgo, D E Mengelle, A Ozols, C Fernandez, C M Autorino
OBJECTIVES: Studies reporting specifically on squeaking in total hip arthroplasty have focused on cementless, and not on hybrid, fixation. We hypothesised that the cement mantle of the femur might have a damping effect on the sound transmitted through the metal stem. The objective of this study was to test the effect of cement on sound propagation along different stem designs and under different fixation conditions. METHODS: An in vitro model for sound detection, composed of a mechanical suspension structure and a sound-registering electronic assembly, was designed...
November 2016: Bone & Joint Research
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