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Molecular Imaging and Radionuclide Therapy

Aamna Hassan, Saima Riaz, Amna Asif
Thyroid incidentalomas are frequently reported on 18 F-FDG PET/CT scan. High risk of malignancy is thought to be associated with increased metabolic activity and high standardized uptake value. Likewise, thyroid nodules with focal FDG avidity have a higher potential to be malignant. However, some benign nodules such as follicular and Hurthle cell adenomas can also present with focal hypermetabolic activity. We report a case of a 59-year-old lady diagnosed with gastric carcinoma, who had a hypermetabolic thyroid nodule on FDG PET/CT scan...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
William Makis, Mark Palayew, Christopher Rush, Stephan Probst
A 60-year-old female with no significant medical history presented with hematuria. A computed tomography (CT) scan revealed extensive lymphadenopathy with hypodensities in the liver and spleen, and she was referred for an 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/CT (PET/CT) study to assess for malignancy of unknown primary. PET/CT revealed extensive 18 F-FDG avid lymphadenopathy as well as innumerable intensely 18 F-FDG avid lung, liver and splenic nodules, highly concerning for malignancy...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Berna Okudan, Nazım Coşkun, Pelin Arıcan, Rıza Şefizade, Seniha Naldöken
Hypertrophic pulmonary osteoarthropathy (HPOA) is a paraneoplastic manifestation of gastric and, more frequently, lung carcinomas. It is characterized by extremity pain, clubbing, arthritis and periostitis of the long bones. Periostitis is the hallmark of HPOA and can be revealed with bone scintigraphy. Whole-body bone scintigraphy (WBBS) is very sensitive during the active lesion period and WBBS findings usually precede that of plain radiography. WBBS can also show improvement in the first 6 months following treatment, thus making it an important technique in the management and follow-up of these patients...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Stephan Probst, Gad Abikhzer, Guillaume Chaussé, Michael Tamilia
Radioactive iodine (RAI) treatment of differentiated thyroid cancer has been used in clinical practice for almost 60 years and is generally accepted to be a safe and efficacious treatment. Severe toxicity in the form of radiation pneumonitis, sometimes progressing to fibrosis, and bone marrow suppression are reported but remain rare. We present a case of severe myelosuppression requiring hospitalization and transfusion support in an otherwise well, young female patient who had received 175 mCi I-131 for low-volume micronodular lung disease one month prior, with a cumulative lifetime administered activity of 575 mCi...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Arzu Cengiz, Sibel Göksel, Yeşim Başal, Şule Taş Gülen, Füruzan Döğer, Yakup Yürekli
Laryngeal tuberculosis is a rare presentation of tuberculosis. It can mimic laryngeal carcinoma with its clinical and imaging findings. A 51-year old woman underwent 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) imaging for clinically suspected carcinoma of the larynx. PET/CT revealed lung lesions consistent with tuberculosis in additional to hypermetabolic focus on larynx. The patient was histopathologically diagnosed with lung and laryngeal tuberculosis.
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Emine Budak, Gürsel Çok, Ayşegül Akgün
OBJECTIVE: Lung cancer is the most common cause of cancer-related death throughout the world, and the correct choice of treatment based on early diagnosis and staging increases the chance of survival. The present study aims to investigate the contribution of fluorine 18-fluorodeoxyglucose-positron emission tomography/computed tomography (18 F-FDG PET/CT) to the management of lung cancer. METHODS: In this study, 50 patients who underwent 18 F-FDG PET/CT for lung cancer diagnosis and staging between February 2012 and February 2014 were included...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Özge Vural Topuz, Fatma Arzu Görtan, Zübeyde Rana Kaya Döner, Çetin Önsel, Haluk Burçak Sayman
OBJECTIVE: We investigated the utility of PET/CT in cutaneous melanoma (CM) patients with pathological negative sentinel lymph nodes (SLN), within the first year. METHODS: The results of PET/CTs and SLN biopsy (SLNB) in 65 patients (39 male and 26 female, mean age 53.8) with a PET/CT in the first postoperative year were evaluated. Within this cohort, the utility of early PET/CT imaging was assessed in patients with negative SLNB. McNemar test was used to compare PET/CT findings with SLNB results...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Kürşat Okuyucu, Semra İnce, Engin Alagöz, Erman Ataş, Nuri Arslan
OBJECTIVE: Primary testicular lymphoma (PTL) is a form of extra-nodal lymphoma originating from the testicles. Currently, positron emission tomography (PET) with glucose analogue 18 F-fluorodeoxyglucose (18 F-FDG) is the most popular and widely used modality for evaluating tumor metabolism, and PTL usually displays increased 18 F-FDG uptake. Despite the rapid increase in clinical applications of FDG PET/ computed tomography (CT), its role in PTL has neither been clearly defined nor reviewed systematically...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Mojtaba Ansari, Hoda Hashemi, Mehdi Soltanshahi, Mohsen Qutbi, Zahra Azizmohammadi, Faraj Tabeie, Hamid Javadi, Esmail Jafari, Maryam Barekat, Majid Assadi
OBJECTIVE: Evaluating the effects of heart cavity volume, presence and absence of perfusion defect, gender and type of study (stress and rest) on the difference of systolic parameters of myocardial perfusion scan in 16 and 8 framing gated SPECT imaging. METHODS: Cardiac gated SPECT in both 16 and 8 framing simultaneously and both stress and rest phases at one-day protocol was performed for 50 patients. Data have been reconstructed by filter back projection (FBP) method and left ventricular (LV) systolic parameters were calculated by using QGS software...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Derya Çayır, Mine Araz, Mahmut Apaydın, Erman Çakal
We present a rare case with inguinal iodine-131 (I-131) uptake on whole body scan. The patient was suffering from a painful right inguinal mass during menstrual period, which was later sonographically and histopathologically confirmed to be an inguinal focus of endometriosis. Endometriosis is a previously reported site of radioiodine uptake and detection of radioiodine uptake in the inguinal region has also been described. Nevertheless, to the best of our knowledge, this is the first case report of I-131 uptake in an inguinal endometriosis focus...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
Güler Silov, Zeynep Erdoğan, Murat Erdoğan, Ayşegül Özdal, Hümeyra Gençer, Tayfun Akalın, Seyhan Karaçavuş
Osteopoikilosis is an inherited condition with autosomal dominant trait resulting in sclerotic foci throughout the skeleton. It has been suggested that loss-of-function mutations of LEMD3 gene located on 12q14.3 result in osetopoikilosis. A bp heterozygote deletion was detected in our patient at the cytosine nucleotide at position 1105 with molecular genetic analysis. Although this mutation has not been previously described, it was considered to be the most likely cause of the disease in our patient due to frame shift and premature stop codon formation...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
William Makis, Anthony Ciarallo, Stephan Probst
A 67-year-old female patient with no prior history of benign thyroid disease was diagnosed with primary thyroid lymphoma and was staged with 18 F-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT). She was treated with chemotherapy and external beam radiation therapy, and a follow-up PET/CT showed significant reduction in the size of the thyroid lymphoma with persistent intense 18 F-FDG uptake, which was interpreted as partial response to therapy. However, two subsequent PET/CT studies showed no change in the persistent intense 18 F-FDG uptake in the thyroid and a biopsy confirmed the presence of thyroiditis with no evidence of residual lymphoma...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
William Makis, Anthony Ciarallo, Stephan Probst
A 65-year-old male patient with a one year history of liver transplantation was referred for an 18 F-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) to rule out post transplant lymphoproliferative disease. Multiple foci of intense abnormal 18 F-FDG uptake were seen in the transplanted liver which were concerning for malignancy. Explantation of the liver approximately 1 month following the PET/CT revealed multiple inflammatory and ischemic changes including large bile duct necrosis, acute cholangitis, bile duct obstruction changes and periportal fibrosis, with no evidence of malignancy...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
William Makis, Emmanuel W Hudson
A 49-year-old male patient with a prior history of poor compliance with medical appointments was referred for an 18 F-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) for the staging of a rectal squamous cell carcinoma. The PET/CT showed unilateral diffuse skeletal muscle 18 F-FDG uptake as well as bilateral salivary gland uptake artifacts, suggestive of non-compliance with patient preparation instructions. The PET/CT nurse noted that during the 18 F-FDG uptake phase, the patient appeared intoxicated, and she found two beer cans hidden in the waste disposal beside his chair just prior to imaging...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
Berna Okudan, Nazım Coşkun, Pelin Arıcan
Stress fractures are injuries most commonly seen in the lower limbs and are usually caused by repetitive stress. While the distal and middle third of the tibia is the most frequent site for stress fractures (almost 50%), stress fractures of the proximal tibia is relatively rare and could be confused with other types of tibial fractures, thus altering management plans for the clinician. Early diagnosis of stress fractures is also important to avoid complications. Imaging plays an important role in the diagnosis of stress fractures, especially bone scan...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
Hüseyin Şan, Kürşat Okuyucu, Ali Ozan Öner, Özdeş Emer, Alper Özgür Karaçalıoğlu
Fibrous dysplasia (FD) is a benign fibroosseous bone disorder. It has poliostotic and monostotic patterns. Monostotic FD is frequently asymptomatic and is usually discovered incidentally by radiologic imaging performed for other reasons. Bone scintigraphy is valuable for identifying disease extent. Craniofacial FD (CFD) is a form of the disease where lesions are limited to contiguous bones of the craniofacial skeleton. We presented a case with monostotic CFD who was detected incidentally on bone scintigraphy single-photon emission computed tomography/computerized tomography while being investigated for inflammatory arthropaties...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
Yeşim Ceylan, Özgür Ömür, Filiz Hatipoğlu
OBJECTIVES: Accurate staging of head and neck cancer (HNC) plays an important role in patient management as well as protection of functional characteristics of the head and neck region. Our aim was to investigate the contribution of 2-[18 F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) as part of HNC staging to clinical evaluation and treatment planning. METHODS: Clinical records of 138 HNC cases who has undergone 18 F-FDG PET/CT imaging were retrospectively reviewed...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
Mustafa Demir, Türkay Toklu, Mohammad Abuqbeitah, Hüseyin Çetin, H Sezer Sezgin, Nami Yeyin, Kerim Sönmezoğlu
OBJECTIVE: The aim of the present study was to compare the performance of positron emission tomography (PET) component of PET/computed tomography (CT) with new emerging PET/magnetic resonance (MR) of the same vendor. METHODS: According to National Electrical Manufacturers Association NU2-07, five separate experimental tests were performed to evaluate the performance of PET scanner of General Electric GE company; SIGNATM model PET/MR and GE Discovery 710 model PET/CT...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
İnan Göktaş, Hakan Cayvarlı
OBJECTIVE: Our aim was to assess the diagnostic performance of integrated positron emission tomography/computed tomography (PET/CT) in the follow-up of breast cancer patients, who underwent a PET/CT scan due to a suspicion of recurrence based on elevated levels of serum tumor markers. METHODS: Seventy-seven consecutive patients were included in this study. PET/CT scan results were compared with the final diagnoses that were obtained from histopathological sampling or a minimum 6 months of radiological follow-up...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
M Fani Bozkurt, Zehra Özcan
No abstract text is available yet for this article.
February 1, 2018: Molecular Imaging and Radionuclide Therapy
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