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Molecular Imaging and Radionuclide Therapy

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https://www.readbyqxmd.com/read/29393056/inguinal-endometriosis-visualized-on-i-131-whole-body-scan
#1
Derya Çayır, Mine Araz, Mahmut Apaydın, Erman Çakal
We present a rare case with inguinal iodine-131 (I-131) uptake on whole body scan. The patient was suffering from a painful right inguinal mass during menstrual period, which was later sonographically and histopathologically confirmed to be an inguinal focus of endometriosis. Endometriosis is a previously reported site of radioiodine uptake and detection of radioiodine uptake in the inguinal region has also been described. Nevertheless, to the best of our knowledge, this is the first case report of I-131 uptake in an inguinal endometriosis focus...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393055/tc-99m-mdp-bone-spect-ct-findings-of-a-patient-detected-with-a-new-mutation-in-lemd3-gene-a-case-of-osteopoikilosis
#2
Güler Silov, Zeynep Erdoğan, Murat Erdoğan, Ayşegül Özdal, Hümeyra Gençer, Tayfun Akalın, Seyhan Karaçavuş
Osteopoikilosis is an inherited condition with autosomal dominant trait resulting in sclerotic foci throughout the skeleton. It has been suggested that loss-of-function mutations of LEMD3 gene located on 12q14.3 result in osetopoikilosis. A bp heterozygote deletion was detected in our patient at the cytosine nucleotide at position 1105 with molecular genetic analysis. Although this mutation has not been previously described, it was considered to be the most likely cause of the disease in our patient due to frame shift and premature stop codon formation...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393054/primary-thyroid-lymphoma-external-beam-radiation-therapy-induced-thyroiditis-mimics-residual-disease-on-serial-18-f-fdg-pet-ct-imaging
#3
William Makis, Anthony Ciarallo, Stephan Probst
A 67-year-old female patient with no prior history of benign thyroid disease was diagnosed with primary thyroid lymphoma and was staged with 18 F-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT). She was treated with chemotherapy and external beam radiation therapy, and a follow-up PET/CT showed significant reduction in the size of the thyroid lymphoma with persistent intense 18 F-FDG uptake, which was interpreted as partial response to therapy. However, two subsequent PET/CT studies showed no change in the persistent intense 18 F-FDG uptake in the thyroid and a biopsy confirmed the presence of thyroiditis with no evidence of residual lymphoma...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393053/inflammatory-and-ischemic-post-liver-transplant-complications-mimic-malignancy-on-18-f-fdg-pet-ct
#4
William Makis, Anthony Ciarallo, Stephan Probst
A 65-year-old male patient with a one year history of liver transplantation was referred for an 18 F-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) to rule out post transplant lymphoproliferative disease. Multiple foci of intense abnormal 18 F-FDG uptake were seen in the transplanted liver which were concerning for malignancy. Explantation of the liver approximately 1 month following the PET/CT revealed multiple inflammatory and ischemic changes including large bile duct necrosis, acute cholangitis, bile duct obstruction changes and periportal fibrosis, with no evidence of malignancy...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393052/unilateral-muscle-artifacts-due-to-non-compliance-during-uptake-phase-of-18-f-fdg-pet-ct-in-an-oncologic-patient
#5
William Makis, Emmanuel W Hudson
A 49-year-old male patient with a prior history of poor compliance with medical appointments was referred for an 18 F-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) for the staging of a rectal squamous cell carcinoma. The PET/CT showed unilateral diffuse skeletal muscle 18 F-FDG uptake as well as bilateral salivary gland uptake artifacts, suggestive of non-compliance with patient preparation instructions. The PET/CT nurse noted that during the 18 F-FDG uptake phase, the patient appeared intoxicated, and she found two beer cans hidden in the waste disposal beside his chair just prior to imaging...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393051/the-contribution-of-spect-ct-in-the-diagnosis-of-stress-fracture-of-the-proximal-tibia
#6
Berna Okudan, Nazım Coşkun, Pelin Arıcan
Stress fractures are injuries most commonly seen in the lower limbs and are usually caused by repetitive stress. While the distal and middle third of the tibia is the most frequent site for stress fractures (almost 50%), stress fractures of the proximal tibia is relatively rare and could be confused with other types of tibial fractures, thus altering management plans for the clinician. Early diagnosis of stress fractures is also important to avoid complications. Imaging plays an important role in the diagnosis of stress fractures, especially bone scan...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393050/sphenoid-bone-fibrous-dysplasia-detected-incidentally-on-bone-scintigraphy-by-the-contribution-of-spect-ct-hybrid-imaging
#7
Hüseyin Şan, Kürşat Okuyucu, Ali Ozan Öner, Özdeş Emer, Alper Özgür Karaçalıoğlu
Fibrous dysplasia (FD) is a benign fibroosseous bone disorder. It has poliostotic and monostotic patterns. Monostotic FD is frequently asymptomatic and is usually discovered incidentally by radiologic imaging performed for other reasons. Bone scintigraphy is valuable for identifying disease extent. Craniofacial FD (CFD) is a form of the disease where lesions are limited to contiguous bones of the craniofacial skeleton. We presented a case with monostotic CFD who was detected incidentally on bone scintigraphy single-photon emission computed tomography/computerized tomography while being investigated for inflammatory arthropaties...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393049/contribution-of-18-f-fdg-pet-ct-to-staging-of-head-and-neck-malignancies
#8
Yeşim Ceylan, Özgür Ömür, Filiz Hatipoğlu
OBJECTIVES: Accurate staging of head and neck cancer (HNC) plays an important role in patient management as well as protection of functional characteristics of the head and neck region. Our aim was to investigate the contribution of 2-[18 F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) as part of HNC staging to clinical evaluation and treatment planning. METHODS: Clinical records of 138 HNC cases who has undergone 18 F-FDG PET/CT imaging were retrospectively reviewed...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393048/evaluation-of-pet-scanner-performance-in-pet-mr-and-pet-ct-systems-nema-tests
#9
Mustafa Demir, Türkay Toklu, Mohammad Abuqbeitah, Hüseyin Çetin, H Sezer Sezgin, Nami Yeyin, Kerim Sönmezoğlu
OBJECTIVE: The aim of the present study was to compare the performance of positron emission tomography (PET) component of PET/computed tomography (CT) with new emerging PET/magnetic resonance (MR) of the same vendor. METHODS: According to National Electrical Manufacturers Association NU2-07, five separate experimental tests were performed to evaluate the performance of PET scanner of General Electric GE company; SIGNATM model PET/MR and GE Discovery 710 model PET/CT...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393047/the-role-of-18-f-fdg-pet-ct-in-evaluating-elevated-levels-of-tumor-markers-in-breast-cancer
#10
İnan Göktaş, Hakan Cayvarlı
OBJECTIVE: Our aim was to assess the diagnostic performance of integrated positron emission tomography/computed tomography (PET/CT) in the follow-up of breast cancer patients, who underwent a PET/CT scan due to a suspicion of recurrence based on elevated levels of serum tumor markers. METHODS: Seventy-seven consecutive patients were included in this study. PET/CT scan results were compared with the final diagnoses that were obtained from histopathological sampling or a minimum 6 months of radiological follow-up...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29393046/the-evolving-role-of-nuclear-medicine-and-molecular-imaging-theranostics-and-personalized-therapeutic-applications
#11
M Fani Bozkurt, Zehra Özcan
No abstract text is available yet for this article.
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976338/false-positive-perfusion-ventilation-spect-study-for-pulmonary-embolism-in-a-patient-with-fontan-circulation
#12
Emmanouil Panagiotidis
Fontan circulation is the consequence of an operation that results in the flow of systemic venous blood to the lungs without passing through a ventricle. An 18-year old man with a history of congenital heart disease surgically treated with Fontan circulation, presented with pleuritic chest pain and a raised D-dimer level. Perfusion/ventilation SPECT was performed to exclude the possibility of pulmonary embolism (PE) that showed unilateral reduced perfusion of the left lung with a mismatched right upper lobe defect, suspicious of PE...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976337/incidental-tc-99m-methylene-diphosphonate-uptake-in-an-active-thyroid-nodule
#13
Derya Çayır, Mine Araz, Şafak Akın, Melia Karaköse, Erman Çakal
Tc-99m-methylene diphosphonate (MDP) whole body scintigraphy is the method of choice for detection of metastatic bone diseases. It is primarily used to help diagnose various bone-related conditions such as primary or metastatic cancer of the bone, location of bone inflammation, and fractures that may not be visible on traditional X-ray images, as well as detection of bone damage due to infections and other conditions. In addition, bone scanning is often used for the follow-up or evaluation of response to treatment in some malignancies like prostate and breast cancers...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976336/cyclosporine-and-vancomycin-amikacin-induced-hot-kidney-appearance-in-a-young-adult-and-a-pediatric-patient
#14
Derya Çayır, Mine Araz, Mustafa Filik, Mehmet Erdoğan
The appearance of a hot kidney on bone scintigraphy is rare and can be seen due to various factors. In our clinic, we observed hot kidney appearance in two patients to whom technetium-99m methylene diphosphonate (Tc-99m MDP) whole body scan has been performed: a young male adult at the age of 18 who was diagnosed with acute lymphocytic leukemia with a presumptive diagnosis of avascular necrosis, and a 9-year-old girl with cystitis for a pre-diagnosis of osteomyelitis. The first patient had a history of cyclosporine usage and the second patient was being treated with amikacin + vancomycin...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976335/two-uncommon-sites-of-metastasis-breast-and-hypophysis-metastases-of-head-and-neck-adenoid-cystic-carcinoma-detected-by-fdg-pet-ct
#15
Evrim Sürer Budak, Şenay Yıldırım, Sevim Yıldız, Ali Ozan Öner, Şeyda Gündüz
Adenoid cystic carcinoma (ACC) is a rare epithelial malignancy arising from secretory glands, particularly the salivary glands. It tends to invade nerves and has a high potential for distant hematogenous metastasis, especially to the lungs, bone, liver and brain. The breast and hypophysis are not common sites of ACC metastatic disease. Herein, we report a case of ACC of the head and neck region with two unusual sites of metastases, the hypophysis and breast.
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976334/super-scan-caused-by-parathyroid-carcinoma-observed-both-in18f-fdg-pet-ct-scan-and-tc-99m-mdp-bone-scintigraphy
#16
İsa Burak Güney, Semra Paydaş, Hüseyin Tuğsan Ballı
Super scan is a well-known finding described in skeletal scintigraphy characterized by uniform symmetrically increased radiopharmaceutical uptake by bones and consequently diminished renal parenchymal activity. Sy et al. hypothesized that the faint visualization of renal cortex in bone scintigraphy might be the result of increased uptake of radiopharmaceutical by pathologic bones and reduced phosphate excretion. The super scan on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has been observed in various conditions such as prostate cancer, lung cancer, renal adenocarcinoma, gastric cancer and primitive neuroectodermal tumor of the kidney...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976333/a-comparison-of-iterative-reconstruction-and-prone-imaging-in-reducing-the-inferior-wall-attenuation-in-tc-99m-sestamibi-myocardial-perfusion-spect
#17
Duygu Kuşlu, Emel Öztürk
OBJECTIVE: Prone positioning, iterative reconstruction (IR-OSEM) and electrocardiography (ECG) gating have been demonstrated to improve the specificity of myocardial perfusion SPECT (MPS) in the diagnosis of coronary artery disease. METHODS: The gated supine and prone MPS images of 45 patients were reconstructed with both IR-OSEM [supine (SIR) and prone (PIR)] FBPs [supine (SFBP), prone (PFBP)] for comparison. Perfusion, wall motion (WM) and wall thickening were also interpreted semi-quantitatively...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976332/bone-single-photon-emission-computed-tomography-in-the-detection-of-sacroiliitis-in-seronegative-spondyloarthritis-a-comparison-with-magnetic-resonance-imaging
#18
Theodoros Pipikos, Dimitrios Kassimos, George Angelidis, John Koutsikos
OBJECTIVE: Seronegative spondyloarthritis (SpA) is characterized by chronic inflammation affecting the axial skeleton, entheses and occasionally peripheral joints. The involvement of the sacroiliac joints, sacroiliitis, is considered as a pathognomonic radiographic finding. Magnetic resonance imaging (MRI) is the method of choice for its early detection. Bone scintigraphy (BS) is characterized by high sensitivity in the diagnosis of bone and articular diseases. Limited value of BS in the diagnosis of sacroiliitis may be attributed to the use of planar imaging...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976331/thyroid-incidentalomas-on-18-f-fdg-pet-ct-clinical-significance-and-controversies
#19
William Makis, Anthony Ciarallo
OBJECTIVE: The purpose of the current study is to examine the incidence and clinical significance of unexpected focal uptake of (18)F-fluorodeoxyglucose ((18)F-FDG) on positron emission tomography/computed tomography (PET/CT) in the thyroid gland of oncology patients, the maximum standardized uptake value (SUVmax) of benign and malignant thyroid incidentalomas in these patients, and review the literature. METHODS: Seven thousand two hundred fifty-two (18)F-FDG PET/CT studies performed over four years, were retrospectively reviewed...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976330/uptake-patterns-of-untreated-primary-gastrointestinal-extranodal-lymphomas-on-initial-staging-18-f-fdg-pet-ct-and-metabolic-tumor-parameters
#20
Engin Alagöz, Kürşat Okuyucu, Semra İnce, Murat Kantarcıoğlu, Şükrü Özaydın, Cumhur Heper, Türker Türker, Nuri Arslan
OBJECTIVE: Non-Hodgkin's lymphomas arising from tissues other than primary lymphatic sites are classified as primary extranodal lymphomas (PEL). PELs of the gastrointestinal system (PGISL) originate from the lymphatic tissues within the gastrointestinal tract. The prognostic value of (18)F-FDG PET/CT in lymphomas is high in terms of both overall survival (OS) and disease-free survival (DFS). Our aim was to investigate the uptake patterns and properties of low-grade and high-grade PGISL on primary staging (18)F-FDG PET/CT, as well as the prognostic significance of metabolic tumor parameters in high grade PGISL...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
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