Read by QxMD icon Read


V L Veenstra, H Damhofer, C Waasdorp, L B van Rijssen, M J van de Vijver, F Dijk, H W Wilmink, M G Besselink, O R Busch, D K Chang, P J Bailey, A V Biankin, H M Kocher, J P Medema, J S Li, R Jiang, D W Pierce, H W M van Laarhoven, M F Bijlsma
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma that harbors tumor-promoting properties. No good biomarkers exist to monitor the effect of stromal targeting therapies or to predict response. We set out to identify such non-invasive markers for PDAC stroma and predict response to therapy. Gene expression datasets, co-culture experiments, xenografts, and patient samples were analyzed. Serum samples were measured from a cohort of 58 resected patients, and 87 metastatic or locally advanced PDAC patients...
November 16, 2018: Oncogenesis
Seung-Shick Shin, Byeong-Seon Jeong, Brian A Wall, Jiadong Li, Naing Lin Shan, Yu Wen, James S Goydos, Suzie Chen
Our research group demonstrated that riluzole, an inhibitor of glutamatergic signaling reduced melanoma cell proliferation in vitro and tumor progression in vivo. The underlying mechanisms of riluzole are largely unknown. Microarray analyses on two human melanoma cell lines revealed that riluzole stimulates expression of the cystine-glutamate amino acid antiporter, xCT (SLC7A11). Western immunoblot analysis from cultured human melanoma or normal melanocytic cells showed that xCT was significantly overexpressed in most melanomas, but not normal cells...
November 14, 2018: Oncogenesis
Zheng Ge, Qi Han, Yan Gu, Qinyu Ge, Jinlong Ma, Justin Sloane, Guofeng Gao, Kimberly J Payne, Laszlo Szekely, Chunhua Song, Sinisa Dovat
Mutations and single nucleotide polymorphisms of AT-rich interactive domain-containing protein 5B (ARID5B) are involved in the oncogenesis of acute lymphoblastic leukemia (ALL) and treatment outcomes. However, ARID5B expression and clinical significance in ALL remain unclear. We found ARID5B is significantly down-regulated in ALL compared to healthy bone marrow controls. ARID5B also interacts with PHD finger protein 2 (PHF2). Low expression of ARID5B (ARID5Blow ) or ARID5B and PHF2 (ARID5Blow PHF2low ) is correlated with the markers of cell proliferation and poor prognosis in ALL patients...
November 12, 2018: Oncogenesis
Cheolwon Choi, Nguyen Thi Thao Tran, Trinh Van Ngu, Sae Woong Park, Min Suk Song, Sung Hyun Kim, Yun-Ui Bae, Penchatr Diskul Na Ayudthaya, Javaria Munir, Eunbit Kim, Moo-Jun Baek, Sujung Song, Seongho Ryu, Kee-Hyun Nam
Thyroid cancer is the fifth most common cancer diagnosed in women worldwide. Notwithstanding advancements in the prognosis and treatment of thyroid cancer, 10-20% of thyroid cancer patients develops chemotherapeutic resistance and experience relapse. According to previous reports and TCGA database, MUC15 (MUCIN 15) upregulation is highly correlated with thyroid cancer progression. However, the role of MUC15 in tumor progression and metastasis is unclear. This study aimed to investigate factors mediating cancer stemness in thyroid cancer...
November 12, 2018: Oncogenesis
Wei Chen, Hao Zhang, Zhifeng Chen, Hao Jiang, Liping Liao, Shijie Fan, Jing Xing, Yiqian Xie, Shijie Chen, Hong Ding, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng, Zhiyi Yao, Yiran Huang, Yuanyuan Zhang
Small molecular inhibitors targeting BRD4 family proteins are emerging as promising therapies in many types of human malignancies. However, whether BRD4, as well as other BET family members, may serve as therapeutic targets in renal cell carcinoma (RCC) remains unknown. In this study, we found that both BRD2 and BRD4 were over-expressed in RCC tissues, knock-down both of which achieved potent anti-proliferative effects in RCC cells. A novel category of BET inhibitors, originated from an approved drug Nitroxoline, were synthesized and evaluated with biochemical and cellular assays, as well as the method of crystallography...
November 2, 2018: Oncogenesis
Claire Marchal, Maud de Dieuleveult, Claude Saint-Ruf, Nadège Guinot, Laure Ferry, Sara T Olalla Saad, Mariana Lazarini, Pierre-Antoine Defossez, Benoit Miotto
DNA methyltransferase inhibitor (DNMTi) treatments have been used for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), and have shown promising beneficial effects in some other types of cancers. Here, we demonstrate that the transcriptional repressor ZBTB38 is a critical regulator of the cellular response to DNMTi. Treatments with 5-azacytidine, or its derivatives decitabine and zebularine, lead to down-regulation of ZBTB38 protein expression in cancer cells, in parallel with cellular damage...
October 11, 2018: Oncogenesis
Batel Shalom, Marganit Farago, Eli Pikarsky, Shulamit Katzav
Vav1 is physiologically active as a GDP/GTP nucleotide exchange factor (GEF) in the hematopoietic system. Overexpression of Vav1 in multiple tumor types is known to enhance oncogenicity, yet whether or not Vav1 is a bona fide oncogene is still a matter of debate. Although mutations in Vav1 were recently identified in human cancers of various origins, the functional activities of these mutants are not known. We tested the transforming potential of three mutations identified in human lung adenocarcinoma: E59K, D517E, and L801P...
October 8, 2018: Oncogenesis
Christopher T Lucido, Juan L Callejas-Valera, Paul L Colbert, Daniel W Vermeer, W Keith Miskimins, William C Spanos, Paola D Vermeer
The incidence of human papillomavirus-associated head and neck squamous cell carcinoma (HPV[ + ] HNSCC) is rapidly increasing. Although clinical management of primary HPV( + ) HNSCC is relatively successful, disease progression, including recurrence and metastasis, is often fatal. Moreover, patients with progressive disease face limited treatment options and significant treatment-associated morbidity. These clinical data highlight the need to identify targetable mechanisms that drive disease progression in HPV( + ) HNSCC to prevent and/or treat progressive disease...
October 8, 2018: Oncogenesis
Xueqing Zheng, Kejing Wu, Shengjie Liao, Yuemei Pan, Yanan Sun, Xinming Chen, Yi Zhang, Shu Xia, Yaying Hu, Jiali Zhang
Oral squamous cell carcinoma (OSCC) represents over 90% of oral cancer incidence, while its mechanisms of tumorigenesis remain poorly characterized. In this study, we applied RNA-seq and microRNA-seq methodologies in four pairs of cancer and adjacent normal tissues to profile the contribution of miRNAs to tumorigenesis-altered functional pathways by constructing a comprehensive miRNA-mediated mRNA regulatory network. There were 213 differentially expressed (DE) miRNAs and 2172 DE mRNAs with the involvement of negative miRNA-mRNA interactions identified by at least two pairs of cancerous tissues...
October 8, 2018: Oncogenesis
Ankit Kumar Patel, Kavya Vipparthi, Venu Thatikonda, Indu Arun, Samsiddhi Bhattacharjee, Rajeev Sharan, Pattatheyil Arun, Sandeep Singh
Cancer-associated fibroblasts (CAFs) demonstrate the characteristics of myofibroblast differentiation by often expressing the ultrastructure of alpha-smooth muscle actin (αSMA). However, heterogeneity among cancer-associated fibroblasts (CAFs), with respect to αSMA expression, has been demonstrated in several clinical studies of oral cancer. Like normal stem cells, stem-like cancer cells (SLCCs) are also regulated extrinsically by its microenvironment; therefore, we postulated that the heterogeneous oral-CAFs would differently regulate oral-SLCCs...
October 5, 2018: Oncogenesis
Yan-Feng Huang, Wen-Bo Niu, Rong Hu, Ling-Jun Wang, Zeng-Yan Huang, Shi-Hao Ni, Ming-Qing Wang, Yi Yang, Yu-Sheng Huang, Wen-Jun Feng, Wei Xiao, Da-Jian Zhu, Shao-Xiang Xian, Lu Lu
Colorectal cancer stem cells (CSCs), characterized by self-renewal ability and high expression of proliferative genes, contribute to the chemoresistance of colorectal cancer (CRC). We aimed to identify the molecular mechanisms underlying CRC chemoresistance through comprehensive bioinformatics screenings and experimental confirmation of gene functions. We found that high expression of FGF1 intracellular binding protein (FIBP) was correlated with chemoresistance and poor prognosis in CRC patients. Therefore, the chemoresistant CRC cell line HCT116-CSC with high expression of the stem cell markers CD44 and CD133 was established for further phenotypic tests...
October 2, 2018: Oncogenesis
Xiaohong Xia, Yuning Liao, Zhiqiang Guo, Yanling Li, Lili Jiang, Fangcheng Zhang, Chuyi Huang, Yuan Liu, Xuejun Wang, Ningning Liu, Jinbao Liu, Hongbiao Huang
Estrogen receptor α (ERα) is expressed in ~67% of breast cancers and is critical to their proliferation and progression. The expression of ERα is regarded as a major prognostic marker, making it a meaningful target to treat breast cancer (BCa). However, hormone receptor-positive BCa was sometimes irresponsive or even resistant to classic anti-hormonal therapies (e.g., fulvestrant and tamoxifen). Hence, novel anti-endocrine therapies are urgent for ERα+ BCa. A phase II study suggested that bortezomib, an inhibitor blocking the activity of 20 S proteasomes, intervenes in cancer progression for anti-endocrine therapy in BCa...
September 24, 2018: Oncogenesis
Alberto Herrera, Mercedes Herrera, Natalia Guerra-Perez, Cristina Galindo-Pumariño, María Jesús Larriba, Vanesa García-Barberán, Beatriz Gil, Sara Giménez-Moyano, Reyes Ferreiro-Monteagudo, Pilar Veguillas, Antonio Candia, Raúl Peña, Jesús Pinto, Mª Laura García-Bermejo, Alberto Muñoz, Antonio García de Herreros, Félix Bonilla, Alfredo Carrato, Cristina Peña
Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mesenchymal Transition, in recent years, many studies have also identified the major role of Snail in the activation of Cancer-Associated Fibroblast (CAF) cells and the remodeling of the extracellular matrix. In CAFs, Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant...
September 24, 2018: Oncogenesis
Yvonne de Jong, David Monderer, Emeline Brandinelli, Morgane Monchanin, Brendy E van den Akker, Jolieke G van Oosterwijk, Jean Yves Blay, Aurélie Dutour, Judith V M G Bovée
Chondrosarcomas are malignant cartilage tumors showing relative resistance to conventional chemo- and radiotherapy. Previous studies showed that chondrosarcoma cells could be sensitized to chemotherapy by inhibiting the Bcl-2 family members Bcl-2, Bcl-xl and Bcl-w using ABT-737. In this study we explored the specific role of Bcl-2 family members to identify the most important player in chondrosarcoma cell survival and chemo resistance. Immunohistochemistry was performed on tissue microarrays containing 137 conventional chondrosarcomas of different grades...
September 21, 2018: Oncogenesis
Stefanie Tiede, Nathalie Meyer-Schaller, Ravi Kiran Reddy Kalathur, Robert Ivanek, Ernesta Fagiani, Philip Schmassmann, Patrick Stillhard, Simon Häfliger, Norbert Kraut, Norbert Schweifer, Irene C Waizenegger, Ruben Bill, Gerhard Christofori
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that regulates a plethora of downstream signaling pathways essential for cell migration, proliferation and death, processes that are exploited by cancer cells during malignant progression. These well-established tumorigenic activities, together with its high expression and activity in different cancer types, highlight FAK as an attractive target for cancer therapy. We have assessed and characterized the therapeutic potential and the biological effects of BI 853520, a novel small chemical inhibitor of FAK, in several preclinical mouse models of breast cancer...
September 20, 2018: Oncogenesis
Mal Irvine, Ashleigh Stewart, Bernadette Pedersen, Suzanah Boyd, Richard Kefford, Helen Rizos
Nearly all patients with BRAF-mutant melanoma will progress on BRAF inhibitor monotherapy and combination BRAF/MEK inhibitor therapy within the first year of therapy. In the vast majority of progressing melanomas, resistance occurs via the re-activation of MAPK signalling, commonly via alterations in BRAF, NRAS and MEK1/2. A small proportion of resistant melanomas rely on the activation of the compensatory PI3K/AKT signalling cascade, although activation of this pathway does not preclude patient responses to BRAF/MEK inhibition...
September 20, 2018: Oncogenesis
Johannes Grimm, Anita Hufnagel, Marion Wobser, Andreas Borst, Sebastian Haferkamp, Roland Houben, Svenja Meierjohann
Approximately half of all melanoma patients harbour activating mutations in the serine/threonine kinase BRAF. This is the basis for one of the main treatment strategies for this tumor type, the targeted therapy with BRAF and MEK inhibitors. While the initial responsiveness to these drugs is high, resistance develops after several months, frequently at sites of the previously responding tumor. This indicates that tumor response is incomplete and that a certain tumor fraction survives even in drug-sensitive patients, e...
September 20, 2018: Oncogenesis
A'dem Bokhari, Vincent Jonchere, Anaïs Lagrange, Romane Bertrand, Magali Svrcek, Laetitia Marisa, Olivier Buhard, Malorie Greene, Anastasia Demidova, Jieshuang Jia, Eric Adriaenssens, Thierry Chassat, Denis S Biard, Jean-François Flejou, Fabrice Lejeune, Alex Duval, Ada Collura
Nonsense-mediated mRNA decay (NMD) is responsible for the degradation of mRNAs with a premature termination codon (PTC). The role of this system in cancer is still quite poorly understood. In the present study, we evaluated the functional consequences of NMD activity in a subgroup of colorectal cancers (CRC) characterized by high levels of mRNAs with a PTC due to widespread instability in microsatellite sequences (MSI). In comparison to microsatellite stable (MSS) CRC, MSI CRC expressed increased levels of two critical activators of the NMD system, UPF1/2 and SMG1/6/7...
September 19, 2018: Oncogenesis
Hongbo Fang, Kaifeng Niu, Dongliang Mo, Yuqi Zhu, Qunsong Tan, Di Wei, Yueyang Li, Zixiang Chen, Shuchen Yang, Adayabalam S Balajee, Yongliang Zhao
Human RecQL4 helicase plays critical roles in the maintenance of genomic stability. Mutations in RecQL4 helicase results in three clinically related autosomal recessive disorders: Rothmund-Thomson syndrome (RTS), RAPADILINO, and Baller-Gerold syndrome. In addition to several premature aging features, RTS patients are characterized by aneuploidy involving either loss or gain of a single chromosome. Chromosome mosaicism and isochromosomes involving chromosomes 2, 7, and 8 have been reported in RecQL4-deficient RTS patients, but the precise role of RecQL4 in chromosome segregation/stability remains to be elucidated...
September 12, 2018: Oncogenesis
Jamie L King, Baotong Zhang, Yixiang Li, Kathy P Li, Jianping J Ni, Harold I Saavedra, Jin-Tang Dong
Abnormal expression of TTK kinase has been associated with the initiation, progression, and therapeutic resistance of breast and other cancers, but its roles remain to be clarified. In this study, we examined the role of TTK in triple negative breast cancer (TNBC), and found that higher TTK expression correlated with mesenchymal and proliferative phenotypes in TNBC cells. Pharmacologic inhibition and genomic silencing of TTK not only reversed the epithelial-to-mesenchymal transition (EMT) in TNBC cells, but also increased the expression of KLF5, an effector of TGF-β signaling and inhibitor of EMT...
September 12, 2018: Oncogenesis
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"