journal
https://read.qxmd.com/read/38192255/the-effects-of-lycopene-on-modulating-oxidative-stress-and-liver-enzymes-levels-in-metabolic-syndrome-patients-a-randomised-clinical-trial
#21
JOURNAL ARTICLE
Mahdi Mirahmadi, Malihe Aghasizadeh, Fatemeh Nazifkar, Mahla Ghafarian Choubdari, Reza Assaran-Darban, Shima Tavallaie, Hossein Hatamzadeh, Gordon Ferns, Mohammad Reza Mirinezhad, Hamed Baharara, Farzin Hadizadeh, Majid Ghayour-Mobarhan
The pathogenesis of metabolic syndrome (MetS) complications involves the excessive production of<br />reactive oxygen species, inflammation, and endothelial dysfunction. Due to Lycopene, a highly unstable structure and<br />its significant effects on modulating the metabolic system, there is a strong need for a formula that can increase its<br />stability. The aim of this study was to develop an approach for encapsulating Lycopene and investigate its effects on<br />inflammatory markers, oxidative stress, and liver enzymes in patients with MetS...
December 31, 2023: Cell Journal
https://read.qxmd.com/read/38192254/sp-8356-a-novel-verbenone-derivative-exerts-in-vitro-anti-non-small-cell-lung-cancer-effects-promotes-apoptosis-via-the-p53-mdm2-axis-and-inhibits-tumor-formation-in-mice
#22
JOURNAL ARTICLE
Lei Yang, Liyi Hu
OBJECTIVE: Non-small cell lung cancer (NSCLC) stands as a prominent contributor to cancer-related fatalities on a global scale, necessitating the search for novel therapeutic agents. SP-8356, a derivative of (1S)-(-)-verbenone, has shown promise as an anticancer agent in preclinical studies. However, specific mechanisms underlying its effects in NSCLC remain to be elucidated. The aim of this research was to explore the in vitro anti-NSCLC effects of SP-8356, elucidate its mechanisms of action, and assess its efficacy in inhibiting tumor formation in a murine model...
December 31, 2023: Cell Journal
https://read.qxmd.com/read/38192253/deciphering-role-of-lncrna-91h-in-liver-cancer-impact-on-tumorigenesis
#23
JOURNAL ARTICLE
Zhiyuan Mo, Zhuangqiang Wang
OBJECTIVE: This study aimed to investigate functional role of long ncRNA (lncRNA) 91H in liver cancer tumorigenesis, focusing on its effect on cell proliferation, apoptosis, cell cycle progression, migration, invasion, epithelial-mesenchymal transition (EMT) and In vivo tumor growth. MATERIALS AND METHODS: In this experimental study, liver cancer tissues and cell lines were analyzed for lncRNA 91H expression using quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
December 31, 2023: Cell Journal
https://read.qxmd.com/read/38192252/left-barrel-cortical-neurons-activity-following-transplantation-of-stem-cells-into-right-lesioned-barrel-cortex-in-rats
#24
JOURNAL ARTICLE
Mansoureh Sabzalizadeh, Mohammad Reza Afarinesh, Ali Derakhshani, Vahid Sheibani
OBJECTIVE: Stem cells (SCs) can improve the functional defects of brain injury. Rodents use their whiskers to get tactile information from their surroundings. The aim of this study was to investigate whether the transplantation of SCs into the lesioned barrel cortex can help neuronal function in the contralateral cortex. MATERIALS AND METHODS: Sixteen male Wistar rats (200-230 g) were used in this experimental study. We induced a mechanical lesion in the right barrel cortex area of rats by removing this area by a 3 mm skin punch...
December 31, 2023: Cell Journal
https://read.qxmd.com/read/38192251/the-effect-of-biomaterials-on-human-dental-pulp-stem-cell-neural-differentiation-a-scoping-review
#25
Maedeh Khatami, Yousef Moradi, Ramyar Rahimi Darehbagh, Donya Azizi, Arash Pooladi, Rojin Ramezani, Seyedeh Asrin Seyedoshohadaei
Neural cells are the most important components of the nervous system and have the duty of electrical signal transmission. Damage to these cells can lead to neurological disorders. Scientists have discovered different methods, such as stem cell therapy, to heal or regenerate damaged neural cells. Dental stem cells are among the different cells used in this method. This review attempts to evaluate the effect of biomaterials mentioned in the cited papers on differentiation of human dental pulp stem cells (hDPSCs) into neural cells for use in stem cell therapy of neurological disorders...
December 31, 2023: Cell Journal
https://read.qxmd.com/read/38071410/association-of-mgll-intronic-c-t-single-nucleotide-polymorphism-rs782440-with-borderline-personality-disorder-a-case-control-study
#26
JOURNAL ARTICLE
Nazanin Hatami Bavarsad, Leila Jahangard, Masood Saidijam, Seyed Asaad Karimi, Ali Reza Soltanian, Elahe Shahriari, Saeid Afshar, Abdolrahman Sarihi
OBJECTIVE: From the perspective of etiology, borderline personality disorder (BPD) is a multifactorial and complex disorder, hence our understanding about the molecular basis and signaling of this disorder is extremely limited. The purpose of this study was evaluating the relationship between BPD and the Monoacylglycerol lipase (MGLL) polymorphism rs782440 in the population of Hamadan, Iran. MATERIALS AND METHODS: In this case-control study, 106 participants including 53 patients with BPD and 53 healthy control subjects were selected by psychiatrists in the Department of Psychiatry at Farshchian Sina Hospital in Hamadan...
November 28, 2023: Cell Journal
https://read.qxmd.com/read/38071409/spinal-cord-injury-affects-gene-expression-of-transmembrane-proteins-in-tissue-and-release-of-extracellular-vesicle-in-blood-in-silico-and-in-vivo-analysis
#27
JOURNAL ARTICLE
Yasmin Mirzaalikhan, Nasim Eslami, Amin Izadi, Faezeh Shekari, Sahar Kiani
OBJECTIVE: Spinal cord injury (SCI) can disrupt membrane transmission by affecting transmembrane channels or neurotransmitter release. This study aimed to explore gene expression changes of transmembrane proteins underlying SCI through bioinformatics approaches and confirming in SCI model in rats. MATERIALS AND METHODS: In this experimental study, the differentially expressed genes (DEGs) in acute and subacute SCI were obtained based on microarray data downloaded from the gene expression omnibus (GEO)...
November 28, 2023: Cell Journal
https://read.qxmd.com/read/38071408/adipose-tissue-derived-mesenchymal-stem-cells-alter-metabolites-of-brain-cholesterol-homeostasis-in-an-alzheimer-s-model
#28
JOURNAL ARTICLE
Mehrnaz Karimi Darabi, Zahra Nazeri, Arash Rafeeinia, Seyedeh Pardis Pezeshki, Alireza Kheirollah, Yaghoob Farbood, Maryam Adelipour, Shirin Azizidoost, Maryam Cheraghzadeh
OBJECTIVE: Disruption of cholesterol homeostasis in Alzheimer's disease (AD) plays a crucial role in disease pathogenesis, making it a potential therapeutic target. Mesenchymal stem cells (MSCs) show promise in treating cognitive impairment and provide a novel therapeutic approach. This study aims to investigate the effects of MSCs on specific metabolites associated with brain cholesterol homeostasis in an AD rat model. MATERIALS AND METHODS: In this experimental study, animals were divided into three groups: control, AD, and AD+MSCs...
November 28, 2023: Cell Journal
https://read.qxmd.com/read/38071407/osteoblastic-differentiation-of-stem-cells-from-human-exfoliated-deciduous-teeth-by-probiotic-hydroxyapatite
#29
JOURNAL ARTICLE
Sabere Nouri, Rasoul Roghanian, Giti Emtiazi, Oguzhan Gunduz, Rasoul Shafiei
OBJECTIVE: Multipotent cells derived from human exfoliated deciduous teeth (SHED) possess the ability to differentiate into various cell types, including osteoblasts. This study aims to simulate the growth induction and osteogenic differentiation of SHED cells using probiotics and their resultant biomaterials. MATERIALS AND METHODS: This experimental study proceeded in two stages. Initially, we evaluated the effect of autoclaved nutrient agar (NA) grown probiotic Bacillus coagulans ( B...
November 28, 2023: Cell Journal
https://read.qxmd.com/read/38071406/melatonin-protects-mouse-type-a-spermatogonial-stem-cells-against-oxidative-stress-via-the-mitochondrial-thioredoxin-system
#30
JOURNAL ARTICLE
Somayeh Heidarizadi, Zahra Rashidi, Cyrus Jalili, Kamran Mansouri, Iraj Rashidi, Behzad Mahaki, Mohammadreza Gholami
OBJECTIVE: Mitochondrial oxidative stress is an important factor in infertility. The mitochondrial thioredoxin system plays an important role in this condition. N-acetyl-5-methoxy tryptamine (melatonin) plays a role in reducing oxidative stress and apoptosis in spermatogonial stem cells (SSCs). In this study, we explore the probable protective effects of melatonin on the mitochondrial thioredoxin system [thioredoxin 2 (Trx2)/Txnip] in SSCs under oxidative stress. MATERIALS AND METHODS: In this experimental study, SSCs were co-cultured two-dimensionally (2D) with Sertoli cells in DMEM culture medium that contained 10% fetal bovine serum (FBS), 1% antibiotics, and 10 ng/ml glial cell-derived neurotrophic factor (GDNF) for 30 days...
November 28, 2023: Cell Journal
https://read.qxmd.com/read/38071413/royan-institute-first-attempts-autotransplantation-of-vitrified-human-ovarian-tissue-in-cancer-patients
#31
Naeimeh Sadat Abtahi, Bita Ebrahimi, Firouzeh Ghaffari, Rohollah Fathi, Mojtaba Rezazadeh Valojerdi, Abolfazl Mehdizadehkashi, Sepideh Khodaverdi, Azar Yahyaei, Maziar Faridi
Today, timely diagnosis and therapeutic progress open a road of hope for survival in cancerous patients. Increased knowledge about the various cytotoxic treatment's impacts on ovarian function and fertility has resulted in a surge in the number of patients seeking to preserve their fertility before starting the anti-cancer treatment process. In this regard, embryo cryopreservation can be recommended for fertility preservation when the woman is married and has adequate time for ovarian stimulation. If patients are prepubertal girls or not married women, oocytes or ovarian tissue can be frozen instead to be used in the future...
November 1, 2023: Cell Journal
https://read.qxmd.com/read/38071412/annexin-a7-and-its-related-protein-suppressor-of-death-domains-regulates-migration-and-proliferation-of-hca-p-cells
#32
JOURNAL ARTICLE
Shaoqing Wang, Qingyang Bai, Xiuwen Yu, Feng Gao, Yurong Sun, Xianyan Wang
OBJECTIVE: This study was to investigate whether annexin A7 (AnnexinA7, ANXA7 ) and its co-related protein tumor cell death domain silencer [suppressor of death domains (SODD)] regulates the migratory phenotype of liver cancer cells. MATERIALS AND METHODS: In this experimental study, expression of ANXA7 in Hca-P cells, PANXA7 downregulated cells and PANXA7 unrelated sequence cells was detected by real-time quantitative polymerase chain reaction (PCR) at mRNA level and western blotting at protein level...
November 1, 2023: Cell Journal
https://read.qxmd.com/read/38071411/the-effect-of-mesenchymal-stem-cells-derived-conditioned-media-in-combination-with-oral-anti-androgenic-drugs-on-male-pattern-baldness-an-animal-study
#33
JOURNAL ARTICLE
Majid Kamali-Dolat Abadi, Gholamhossein Yousefi, Farzaneh Dehghani, Ali Akbar Alizadeh, Abolfazl Jangholi, Mohammad Amin Moadab, Maryam Naseh, Shima Parsa, Golara Nasiri, Negar Azarpira, Mehdi Dianatpour
OBJECTIVE: Androgenetic alopecia (AGA) is a prevalent form of hair loss, mainly caused by follicular sensitivity to androgens. Despite developing different anti-androgen treatment options, the success rate of these treatments has been limited. Using animal models, this study evaluated the therapeutic effects of umbilical cord (UC) stem cell conditioned media (CM) combined with oral anti-androgens for hair regeneration. MATERIALS AND METHODS: In this experimental study, Poloxamer 407 (P407) was used as a drug carrier for subcutaneous testosterone injection...
November 1, 2023: Cell Journal
https://read.qxmd.com/read/37865881/integrative-bioinformatics-analysis-of-the-cell-division-cycle-and-ribosomal-pathways-in-the-rat-varicocele-implications-for-drug-discovery
#34
JOURNAL ARTICLE
Ali Nasr-Esfahani, Ali Valipour Motlagh, Minoo Adib, Kosar Pashaei, Mohammad Hossein Nasr-Esfahani
OBJECTIVE: Varicocele is a common cause of male infertility, affecting a substantial proportion of infertile men. Recent studies have employed transcriptomic analysis to identify candidate genes that may be implicated in the pathogenesis of this condition. Accordingly, this study sought to leverage rat gene expression profiling, along with protein-protein interaction networks, to identify key regulatory genes, related pathways, and potentially effective drugs for the treatment of varicocele...
October 9, 2023: Cell Journal
https://read.qxmd.com/read/37865879/aberrant-expression-of-tet2-accounts-for-dna-hypomethylation-in-varicocele
#35
JOURNAL ARTICLE
Hengameh Taghian Dinani, Nushin Naderi, Marziyeh Tavalaee, Farzaneh Rabiee, Mohammad Hossein Nasr-Esfahani
OBJECTIVE: Epigenetic modifications such as DNA methylation play a key role in male infertility etiology. This study aimed to explore the global DNA methylation status in testicular spermatogenic cells of varicocele-induced rats and consider their semen quality, with a focus on key epigenetic marks, namely 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC), as well as the mRNA and proteins of ten-eleven translocation (TET) methylcytosine dioxygenases 1-3. MATERIALS AND METHODS: In this experimental study, 24 mature male Wistar rats (8 in each group) were assigned amongst the control, sham, and varicocele groups...
October 9, 2023: Cell Journal
https://read.qxmd.com/read/37865876/characterization-of-car-t-cells-manufactured-using-genetically-engineered-artificial-antigen-presenting-cells
#36
JOURNAL ARTICLE
Ali Sayadmanesh, Mohamad Azadbakht, Kheirollah Yari, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Behzad Baradaran, Mohsen Basiri
OBJECTIVE: Chimeric antigen receptor (CAR) T cell therapy has recently emerged as a promising approach for the treatment of different types of cancer. Improving CAR T cell manufacturing in terms of costs and product quality is an important concern for expanding the accessibility of this therapy. One proposed strategy for improving T cell expansion is to use genetically engineered artificial antigen presenting cells (aAPC) expressing a membrane-bound anti-CD3 for T cell activation. The aim of this study was to characterize CAR T cells generated using this aAPC-mediated approach in terms of expansion efficiency, immunophenotype, and cytotoxicity...
October 9, 2023: Cell Journal
https://read.qxmd.com/read/37865875/crispr-cas9-mediated-generation-of-col7a1-deficient-keratinocyte-model-of-recessive-dystrophic-epidermolysis-bullosa
#37
JOURNAL ARTICLE
Farzad Alipour, Mana Ahmadraji, Elham Yektadoost, Parvaneh Mohammadi, Hossein Baharvand, Mohsen Basiri
OBJECTIVE: Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility and ultimately lethal blistering disease caused by mutations in the COL7A1 gene which is responsible for coding type VII collagen. Investigating the pathological mechanisms and novel candidate therapies for RDEB could be fostered by new cellular models. The aim of this study was to employ CRISPR/Cas9 technology in the development of immortalized COL7A1-deficient keratinocyte cell lines intended for application as a cellular model for RDEB in ex vivo studies...
October 9, 2023: Cell Journal
https://read.qxmd.com/read/37865882/a-shadow-of-knowledge-in-stem-cell-science
#38
JOURNAL ARTICLE
Sarina Omid-Shafiee, Moustapha Hassan, Andreas K Nussler, Najimi Mustapha, Massoud Vosough
"Theory of Forms" implies that a genuine version of creatures exists beyond the shapes in this world. Stem cell<br />technology has adopted developmental cues to mimic real life. However, the functionality of the lab-made cells is far<br />from primary ones. Perhaps it is time to switch from analytical to systematic perspective in stem cell science. This<br />may be the way to define new horizons based on the systematic perspective and convergence of science in stem cell<br />biology, bridging the current gap between the shadows of real knowledge in current research and reality in future...
October 1, 2023: Cell Journal
https://read.qxmd.com/read/37865880/the-potential-hepatoprotective-effect-of-vaccinium-arctostaphylos-l-fruit-extract-in-diabetic-rat
#39
JOURNAL ARTICLE
Negar Saliani, Shideh Montasser Kouhsari, Maryam Izad
OBJECTIVE: Vaccinium arctostaphylos has traditionally been employed in Iranian folk medicine to treat diabetes. However, the precise molecular mechanisms underlying its antidiabetic properties remain incompletely understood. The current experiment intended to explore the modulatory effects of V. arctostaphylos fruit ethanolic extract (VAE) on biochemical and molecular events in the livers of diabetic rats. MATERIALS AND METHODS: In this experimental study, male Wistar rats were randomly assigned to four groups: normal control, normal rats with VAE treatment, diabetic control, and diabetic rats with VAE treatment...
October 1, 2023: Cell Journal
https://read.qxmd.com/read/37865878/unraveling-the-effects-of-dicer1-overexpression-on-immune-related-genes-expression-in-mesenchymal-stromal-stem-cells-insights-for-therapeutic-applications
#40
JOURNAL ARTICLE
Hamid Reza Bidkhori, Moein Farshchian, Halimeh Hasanzadeh, Reza Jafarzadeh Esfehani, Reihaneh Alsadat Mahmoudian, Mahdi Moradi Marjaneh, Houshang Rafatpanah
OBJECTIVE: The immunoregulatory properties of mesenchymal stromal/stem cells (MSCs) bring a promise for the treatment of inflammatory diseases. However, their ability to suppress the immune system is unstable. To enhance their effectiveness against immune responses, it may be necessary to manipulate MSCs. Although some dsRNA transcripts come from invading viruses, the majority of dsRNA has an endogenous origin and is known as endo-siRNA. DICER1 is a ribonuclease protein that can generate small RNAs to modulate gene expression at the post-transcriptional level...
October 1, 2023: Cell Journal
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