journal
MENU ▼
Read by QxMD icon Read
search

Cell Journal

journal
https://www.readbyqxmd.com/read/28367427/di-2-ethylhexyl-phthalate-induced-hippocampus-derived-neural-stem-cells-proliferation
#1
Alireza Abdanipour, Ali Noori-Zadeh, Seyed Alireza Mesbah-Namin, Salar Bakhtiyari, Reza Nejatbakhsh, Iraj Jafari Anarkooli
The brain and spinal cord have a limited capacity for self-repair under damaged conditions. One of the best options to overcome these limitations involves the use of phytochemicals as potential therapeutic agents. In this study, we have aimed to investigate the effects of di-(2-ethylhexyl) phthalate (DEHP) on hippocampus-derived neural stem cells (NSCs) proliferation to search phytochemical candidates for possible treatment of neurological diseases using endogenous capacity. In this experimental study, neonatal rat hippocampus-derived NSCs were cultured and treated with various concentrations of DEHP (0, 100, 200, 400 and 600 µM) and Cirsium vulgare (C...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367426/percutaneous-autologous-bone-marrow-derived-mesenchymal-stromal-cell-implantation-is-safe-for-reconstruction-of-human-lower-limb-long-bone-atrophic-nonunion
#2
Mohsen Emadedin, Narges Labibzadeh, Roghayeh Fazeli, Fatemeh Mohseni, Seyedeh Esmat Hosseini, Reza Moghadasali, Soura Mardpour, Vajiheh Azimian, Alireza Goodarzi, Maede Ghorbani Liastani, Ali Mirazimi Bafghi, Mohamadreza Baghaban Eslaminejad, Nasser Aghdami
OBJECTIVE: Nonunion is defined as a minimum of a 9-month period of time since an injury with no visibly progressive signs of healing for 3 months. Recent studies show that application of mesenchymal stromal cells (MSCs) in the laboratory setting is effective for bone regeneration. Animal studies have shown that MSCs can be used to treat nonunions. For the first time in an Iranian population, the present study investigated the safety of MSC implantation to treat human lower limb long bone nonunion...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367425/sodium-nitroprusside-changed-the-metabolism-of-mesenchymal-stem-cells-to-an-anaerobic-state-while-viability-and-proliferation-remained-intact
#3
Sadiyeh Pari, Mohammad Hussein Abnosi, Reza Pakyari
OBJECTIVE: We used sodium nitroprusside (SNP), a nitric oxide (NO) releasing molecule, to understand its effect on viability and proliferation of rat bone marrow mesenchymal stem cells (BM-MSCs). MATERIALS AND METHODS: This experimental study evaluated the viability and morphology of MSCs in the presence of SNP (100 to 2000 µM) at 1, 5, and 15 hours. We chose the 100, 1000, and 2000 µM concentrations of SNP for one hour exposure for further analyses. Cell proliferation was investigated by the colony forming assay and population doubling number (PDN)...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367424/adipose-derived-stem-cells-exert-immunomodulatory-effects-on-natural-killer-cells-in-breast-cancer
#4
Behdokht Bahrami, Ahmad Hosseini, Abdol-Rasoul Talei, Abbas Ghaderi, Mahboobeh Razmkhah
OBJECTIVE: Adipose derived stem cells (ASCs), as one of the important stromal cells in the tumor microenvironment, are determined with immunomodulatory effects. The principle aim of this study was to evaluate the immunosuppressive effects of ASCs on natural killer (NK) cells. MATERIALS AND METHODS: In this experimental study, we assessed the expressions of indolamine 2, 3-dioxygenase (IDO1), IDO2 and human leukocyte antigen-G5 (HLA-G5) in ASCs isolated from breast cancer patients with different stages as well as normal individuals, using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367423/inhibitory-effect-of-mesenchymal-stem-cell-co-culture-on-erythroid-differentiation-of-k562-cells-compared-to-the-control-group
#5
Mahshid Saleh, Karim Shamsasanjan, Ali Akbari Movassaghpour, Parvin Akbarzadehlaleh, Zahra Molaeipour
OBJECTIVE: Bone marrow mesenchymal stem cells (BMMSCs) reside in the bone marrow and control the process of hematopoiesis. They are an excellent instrument for regenerative treatment and co-culture with hematopoietic stem cells (HSCs). MATERIALS AND METHODS: In this experimental study, K562 cell lines were either treated with butyric acid and co-cultured with MSCs, or cultivated in a conditioned medium from MSCs plus butyric acid for erythroid differentiation. We used the trypan blue dye exclusion assay to determine cell counts and viability in each group...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367422/adipose-derived-mesenchymal-stem-cells-for-treatment-of-airway-injuries-in-a-patient-after-long-term-exposure-to-sulfur-mustard
#6
Amir Nejad-Moghaddam, Soheila Ajdari, Eisa Tahmasbpour, Hassan Goodarzi, Yunes Panahi, Mostafa Ghanei
OBJECTIVE: Sulfur mustard (SM) is a potent mutagenic agent that targets several organs, particularly lung tissue. Changes in morphological structure of the airway system are associated with chronic obstructive pulmonary deficiency following exposure to SM. Although numerous studies have demonstrated pathological effects of SM on respiratory organs, unfortunately there is no effective treatment to inhibit further respiratory injuries or induce repair in these patients. Due to the extensive progress and achievements in stem cell therapy, we have aimed to evaluate safety and potential efficacy of systemic mesenchymal stem cell (MSC) administration on a SM-exposed patient with chronic lung injuries...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367421/coadministration-of-dexamethasone-and-melissa-officinalis-has-neuroprotective-effects-in-rat-animal-model-with-spinal-cord-injury
#7
Seyed Ruhollah Hosseini, Gholamreza Kaka, Mohammad Taghi Joghataei, Mehdi Hooshmandi, Seyed Homayoon Sadraie, Kayvan Yaghoobi, Korosh Mansoori, Alireza Mohammadi
OBJECTIVE: Spinal cord injury (SCI) causes inflammation, deformity and cell loss. It has been shown that Melissa officinalis (MO), as herbal medicine, and dexamethasone (DEX) are useful in the prevention of various neurological diseases. The present study evaluated combinational effects of DEX and MO on spinal cord injury. MATERIALS AND METHODS: Thirty six adult male Wistar rats were used in this experimental study. The weight-drop contusion method was employed to induce spinal cord injury in rats...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367420/comparative-study-on-the-preventive-effect-of-saffron-carotenoids-crocin-and-crocetin-in-nmu-induced-breast-cancer-in-rats
#8
Meysam Sajjadi, Zahra Bathaie
OBJECTIVE: Crocin (Cro) and crocetin (Crt) are two widely known saffron carotenoids, which exert anticancer effects by different mechanisms. Here, we investigated and compared the preventive effect of Cro and Crt at the initiation and promotion stages of breast cancer induction in an animal model. MATERIALS AND METHODS: In this experimental study, female Wistar albino rats were injected with three doses of N-methyl-N-nitrosourea (NMU). The preventive intervention was done at different times for the initiation and promotion stages...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367419/lavandula-reduces-heart-injury-via-attenuating-tumor-necrosis-factor-alpha-and-oxidative-stress-in-a-rat-model-of-infarct-like-myocardial-injury
#9
Jafar Sadeghzadeh, Abedin Vakili, Ahmad Reza Bandegi, Hamid Reza Sameni, Mahdi Zahedi Khorasani, Mohsen Darabian
OBJECTIVE: Lavender is used in herbal medicine for different therapeutic purposes. Nonetheless, potential therapeutic effects of this plant in ischemic heart disease and its possible mechanisms remain to be investigated. MATERIALS AND METHODS: In this experimental study, lavender oil at doses of 200, 400 or 800 mg/kg was administered through gastric gavage for 14 days before infarct-like myocardial injury (MI). The carotid artery and left ventricle were cannulated to record arterial blood pressure (BP) and cardiac function...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367418/micro-environmental-signature-of-the-interactions-between-druggable-target-protein-dipeptidyl-peptidase-iv-and-anti-diabetic-drugs
#10
Chiranjib Chakraborty, Bidyut Mallick, Ashish Ranjan Sharma, Garima Sharma, Supriya Jagga, C George Priya Doss, Ju-Suk Nam, Sang-Soo Lee
OBJECTIVE: Druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. Therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. To understand such micro-environment, we performed in silico interaction analysis between a human target protein, Dipeptidyl Peptidase-IV (DPP-4), and three anti-diabetic drugs (saxagliptin, linagliptin and vildagliptin)...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367417/lovastatin-reduces-stemness-via-epigenetic-reprograming-of-bmp2-and-gata2-in-human-endometrium-and-endometriosis
#11
Mahdieh Taghizadeh, Mehrdad Noruzinia
OBJECTIVE: The stem cell theory in the endometriosis provides an advanced avenue of targeting these cells as a novel therapy to eliminate endometriosis. In this regard, studies showed that lovastatin alters the cells from a stem-like state to more differentiated condition and reduces stemness. The aim of this study was to investigate whether lovastatin treatment could influence expression and methylation patterns of genes regulating differentiation of endometrial mesenchymal stem cells (eMSCs) such as BMP2, GATA2 and RUNX2 as well as eMSCs markers...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367416/effects-of-a-4-week-aerobic-exercise-on-lipid-profile-and-expression-of-lxr%C3%AE-in-rat-liver
#12
Fatemeh Kazeminasab, Mohammad Marandi, Kamran Ghaedi, Fahimeh Esfarjani, Jamal Moshtaghian
OBJECTIVE: Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear hormonal receptor superfamily which modulate the expression of genes involved in cholesterol homeostasis. Hence, further unraveling of the molecular function of this gene may be helpful in preventing cardiovascular diseases. MATERIALS AND METHODS: This experimental intervention study included twelve adult Wistar male rats (12-14 weeks old, 200-220 g) which were divided into the control (n=6) and training (n=6) groups...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367415/effects-of-electromagnetic-stimulation-on-gene-expression-of-mesenchymal-stem-cells-and-repair-of-bone-lesions
#13
Maryam Jazayeri, Mohammad Ali Shokrgozar, Nooshin Haghighipour, Bahram Bolouri, Fereshteh Mirahmadi, Mehdi Farokhi
OBJECTIVE: Most people experience bone damage and bone disorders during their lifetimes. The use of autografts is a suitable way for injury recovery and healing. Mesenchymal stem cells (MSCs) are key players in tissue engineering and regenerative medicine. Their proliferation potential and multipotent differentiation ability enable MSCs to be considered as appropriate cells for therapy and clinical applications. Differentiation of stem cells depends on their microenvironment and biophysical stimulations...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367414/the-prevalence-of-y-chromosome-microdeletions-in-iranian-infertile-men-with-azoospermia-and-severe-oligospermia
#14
Fahimeh Asadi, Mohammad Ali Sadighi Gilani, Azadeh Ghaheri, Javad Roodgar Saffari, Mohammadreza Zamanian
OBJECTIVE: Microdeletions of the Y chromosome long arm are the most common molecular genetic causes of severe infertility in men. They affect three regions including azoospermia factors (AZFa, AZFb and AZFc), which contain various genes involved in spermatogenesis. The aim of the present study was to reveal the patterns of Y chromosome microdeletions in Iranian infertile men referred to Royan Institute with azoospermia/ severe oligospermia. MATERIALS AND METHODS: Through a cross-sectional study, 1885 infertile men referred to Royan Institute with azoospermia/severe oligospermia were examined for Y chromosome microdeletions from March 2012 to March 2014...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367413/expression-of-folliculogenesis-related-genes-in-vitrified-human-ovarian-tissue-after-two-weeks-in-vitro-culture
#15
Zahra Shams Mofarahe, Mojdeh Salehnia, Marefat Ghaffari Novin, Nassim Ghorbanmehr, Mohammad Gholami Fesharaki
OBJECTIVE: This study was designed to evaluate the effects of vitrification and in vitro culture of human ovarian tissue on the expression of oocytic and follicular cell-related genes. MATERIALS AND METHODS: In this experimental study, ovarian tissue samples were obtained from eight transsexual women. Samples were cut into small fragments and were then assigned to vitrified and non-vitrified groups. In each group, some tissue fragments were divided into un-cultured and cultured (in α-MEM medium for 2 weeks) subgroups...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367412/a-review-on-various-uses-of-n-acetyl-cysteine
#16
REVIEW
Vida Mokhtari, Parvaneh Afsharian, Maryam Shahhoseini, Seyed Mehdi Kalantar, Ashraf Moini
N-acetyl cysteine (NAC), as a nutritional supplement, is a greatly applied antioxidant in vivo and in vitro. NAC is a precursor of L-cysteine that results in glutathione elevation biosynthesis. It acts directly as a scavenger of free radicals, especially oxygen radicals. NAC is a powerful antioxidant. It is also recommended as a potential treatment option for different disorders resulted from generation of free oxygen radicals. Additionally, it is a protected and endured mucolytic drug that mellows tenacious mucous discharges...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28367411/multiple-sclerosis-pathogenesis-symptoms-diagnoses-and-cell-based-therapy
#17
REVIEW
Nazem Ghasemi, Shahnaz Razavi, Elham Nikzad
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmental factors such as exposure to infectious agents, vitamin deficiencies, and smoking. These agents are able to trigger a cascade of events in the immune system which lead to neuronal cell death accompanied by nerve demyelination and neuronal dysfunction...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28042545/comparative-in-vitro-evaluation-of-human-dental-pulp-and-follicle-stem-cell-commitment
#18
Razieh Karamzadeh, Mohamadreza Baghaban Eslaminejad, Ali Sharifi-Zarchi
OBJECTIVE: Pulp and periodontal tissues are well-known sources of mesenchymal stem cells (MSCs) that provide a promising place in tissue engineering and regenerative medicine. The molecular mechanisms underlying commitment and differentiation of dental stem cells that originate from different dental tissues are not fully understood. In this study, we have compared the expression levels of pluripotency factors along with immunological and developmentally-related markers in the culture of human dental pulp stem cells (hDPSCs), human dental follicle stem cells (hDFSCs), and human embryonic stem cells (hESCs)...
2017: Cell Journal
https://www.readbyqxmd.com/read/28042544/indoleamine-2-3-dioxygenase-is-dispensable-for-the-immunomodulatory-function-of-stem-cells-from-human-exfoliated-deciduous-teeth
#19
Razieh Alipour, Masoumeh Masoumi Karimi, Batool Hashemi-Beni, Minoo Adib, Nasrin Sereshki, Farzaneh Sadeghi
OBJECTIVE: In this study, we sought to better understand the immunoregulatory function of stem cells derived from human exfoliated deciduous teeth (SHED). We studied the role of the interferon gamma (IFN-γ)-indoleamine 2,3-dioxygenase (IDO)-axis in immunoregulation of SHED compared to bone marrow derived mesenchymal stem cells (BMMSCs) under the same conditions. MATERIALS AND METHODS: In this cross-sectional study, recently isolated human T cells were stimulated either by mitogen or inactivated allogeneic peripheral blood mononuclear cells (PBMCs)...
2017: Cell Journal
https://www.readbyqxmd.com/read/28042543/relationship-between-potential-sperm-factors-involved-in-oocyte-activation-and-sperm-dna-fragmentation-with-intra-cytoplasmic-sperm-injection-clinical-outcomes
#20
Marziyeh Tavalaee, Abbas Kiani-Esfahani, Mohammad Hossein Nasr-Esfahani
OBJECTIVE: The present study aimed to simultaneously evaluate the association between expression of three potential factors [post-acrosomal sheath WW domain-binding protein (PAWP), phospholipase Cζ (PLCζ), and truncated form of the kit receptor (TR-KIT)] as candidates of oocyte activation with fertilization rate and early embryonic development. MATERIALS AND METHODS: In this experimental study, semen samples were collected from 35 intra-cytoplasmic sperm injection (ICSI) candidates and analyzed according to World Health Organization criteria (2010)...
2017: Cell Journal
journal
journal
47409
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"