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https://www.readbyqxmd.com/read/29105403/association-between-jmjd1a-expression-and-sperm-retrieval-in-non-obstructive-azoospermic-patients
#1
Zahra Eelaminejad, Raha Favaedi, Tahereh Modarresi, Marjan Sabbaghian, Mohammad Ali Sadighi Gilani, Maryam Shahhoseini
Identification of molecular markers which can predict the outcome of sperm retrieval non-invasively in patients with non-obstructive azoospermia (NOA) are valuable in clinical andrology. Jumonji domain-containing 1a (JMJD1A) is a significant epigenetic regulator during spermatogenesis, which plays an important role in the differentiation of post-meiotic germ cells into mature spermatozoa. We therefore aimed to examine the potential association between JMJD1A expression and the outcome of sperm retrieval in patients with NOA...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105402/adipose-derived-stem-cells-affect-mir-145-and-p53-expressions-of-co-cultured-hematopoietic-stem-cells
#2
Tahereh Foroutan, Aisan Farhadi, Saeed Abroun, Bahram Mohammad Soltani
OBJECTIVES: Umbilical cord blood is used for transplantation purposes in regenerative medicine of hematological disorders. MicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as cancer development and incidence. There is a new relation between p53 (tumor suppressor gene) and miR-145 (suppressor of cell growth) upregulation. In this study, we have assessed how adipose-derived stem cells (ADSCs) affect the expansion of hematopoietic stem cells (HSCs), as well as miR-145 and p53 expressions...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105401/bioinformatic-analysis-identifies-three-potentially-key-differentially-expressed-genes-in-peripheral-blood-mononuclear-cells-of-patients-with-takayasu-s-arteritis
#3
Renping Huang, Yang He, Bei Sun, Bing Liu
OBJECTIVES: This study aimed to identify several potentially key genes associated with the pathogenesis of Takayasu's arteritis (TA). This identification may lead to a deeper mechanistic understanding of TA etiology and pave the way for potential therapeutic approaches. MATERIALS AND METHODS: In this experimental study, the microarray dataset GSE33910, which includes expression data for peripheral blood mononuclear cell (PBMC) samples isolated from TA patients and normal volunteers, was downloaded from the publicly accessible Gene Expression Omnibus (GEO) database...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105400/effects-of-klf4-and-c-myc-knockdown-on-pluripotency-maintenance-in-porcine-induced-pluripotent-stem-cell
#4
Yu-Jing Liao, Yi-Shiou Chen, Ja-Xin Lee, Lih-Ren Chen, Jenn-Rong Yang
OBJECTIVES: The importance of Oct4 and Sox2 in maintaining pluripotency and self-renewal is well-understood, but the functions of Klf4 and c-Myc has not been fully investigated. In the present study, we attempted to determine the roles of Klf4 and c-Myc on pluripotency maintenance of porcine induced pluripotent stem (piPS) cells. MATERIALS AND METHODS: In this experimental study, we performed short hairpin RNA (shRNA) to knock down the Klf4 and c-Myc functions of piPS cells and examined pluripotency markers and teratoma formation to evaluate piPS cell pluripotency...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105399/upregulation-of-integrin-%C3%AE-6-and-integrin-%C3%AE-1-gene-expressions-in-mouse-spermatogonial-stem-cells-after-continues-and-pulsed-low-intensity-ultrasound-stimulation
#5
Mahdi Mohaqiq, Mansoureh Movahedin, Manijhe Mokhtari Dizaji, Zohreh Mazaheri
OBJECTIVES: low intensity ultrasound (continues and pulsed) is a form of energy. Spermatogonial stem cells (SSCs) are at the base of male fertility. This study investigated the effects of low intensity ultrasound stimulation (LIUS) and low intensity pulsed ultrasound stimulation (LIUPS) on the expression of germ cell-specific and pluripotency genes in SSCs in vitro. MATERIALS AND METHODS: In this experimental study, isolated SSCs from neonatal male mice were cultured in Dulbecco's Modified Eagle's Medium (DMEM) with 10% fetal bovine serum (FBS)...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105398/oral-quercetin-supplementation-enhances-adiponectin-receptor-transcript-expression-in-polycystic-ovary-syndrome-patients-a-randomized-placebo-controlled-double-blind-clinical-trial
#6
Neda Rezvan, Ashraf Moini, Sattar Gorgani-Firuzjaee, Mohammad Javad Hosseinzadeh-Attar
OBJECTIVES: Polycystic ovary syndrome (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as quercetin have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105397/the-impact-of-genetic-variation-and-gene-expression-level-of-the-follicle-stimulating-hormone-receptor-on-ovarian-reserve
#7
Zeinab Ghezelayagh, Mehdi Totonchi, Shabnam Zarei-Moradi, Ommolbanin Asadpour, Saman Maroufizadeh, Poopak Eftekhari-Yazdi, Hamid Gourabi, Anahita Mohseni-Meybodi
OBJECTIVES: Ovarian reserve is defined as the capacity of the ovary to provide fertile oocytes. Diminished ovarian reserve (DOR) is a disorder in which ovaries are prone to go through early menopause. Where this loss of function occurs before the age of 40, it results in the premature ovarian failure (POF) disease. Throughout folliculogenesis, the follicle-stimulating hormone receptor (FSHR) starts a signaling cascade in the granulosa cells where its inactivation leads to the arrest of follicle maturation and therefore adversely affects ovarian reserve...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105396/effects-of-re-vitrification-of-mouse-morula-and-early-blastocyst-stages-on-apoptotic-gene-expression-and-developmental-potential
#8
Nasrin Majidi Gharenaz, Mansoureh Movahedin, Zohreh Mazaheri
OBJECTIVES: Re-vitrification of embryos immediately after thawing or after a culture period could be used to preserve the extra embryos after embryo transfer. This study aims to clarify the effect of re-vitrification on Bax and Bcl-2 gene expressions of compact and early blastocyst stage embryos. MATERIALS AND METHODS: This experimental study was performed on mouse embryos. We collected 8-cell stage embryos (n=400) from female mature mice, 60-62 hoursafter injection of human chorionic gonadotropin (hCG)...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105395/the-effect-of-vitrification-on-expression-and-histone-marks-of-igf2-and-oct4-in-blastocysts-cultured-from-two-cell-mouse-embryos
#9
Maryam Jahangiri, Maryam Shahhoseini, Bahar Movaghar
OBJECTIVES: Vitrification is increasingly used in assisted reproductive technology (ART) laboratories worldwide. In this study the effect of vitrification on the expression and modifications of H3 histones of Igf2 and Oct4 was investigated in blastocysts cultured from vitrified and non-vitrified two-cell embryos. MATERIALS AND METHODS: In this experimental study, two-cell embryos were cultured in KSOM medium to reach the blastocyst stage. Expression of Igf2 and Oct4 and modifications of H3 histones in regulatory regions of both genes were compared with in vivo blastocysts, which comprise the control group...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105394/melatonin-pretreated-blastocysts-along-with-calcitonin-administration-improved-implantation-by-upregulation-of-heparin-binding-epidermal-growth-factor-expression-in-murine-endometrium
#10
Fatemeh Moghani-Ghoroghi, Ghazaleh Moshkdanian, Mojtaba Sehat, Seyed Noureddin Nematollahi-Mahani, Iraj Ragerdi-Kashani, Parichehr Pasbakhsh
OBJECTIVES: Implantation failure is an obstacle in assisted reproduction techniques (ART). Calcitonin is a molecules involved in uterine receptivity and embryo implantation. Melatonin can promote embryo quality and improve implantation. This study examines the effect of pretreatment of blastocysts with melatonin and calcitonin on heparin binding-epidermal growth factor (HB-EGF) expression in murine endometrium. MATERIALS AND METHODS: In this experimental study, we collected 2-cell embryos from the oviducts of 1...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105393/isolation-characterization-and-osteogenic-potential-of-mouse-digit-tip-blastema-cells-in-comparison-with-bone-marrow-derived-mesenchymal-stem-cells-in-vitro
#11
Leila Taghiyar, Samaneh Hosseini, Mahdi Hesaraki, Forough Azam Sayahpour, Nasser Aghdami, Mohamadreza Baghaban Eslaminejad
OBJECTIVES: Limb regeneration mediated by blastema cells (BlCs) in mammals is limited to the digit tips of neonates. Due to the lack of access to BlCs in adults and the difficulty in isolating and expanding BlCs from neonates, the use of a cellular population with similar features of BlCs would be a valuable strategy to direct a non-regenerative wound towards regeneration. In this study, we have initially isolated and cultured BlCs, and explored their characteristics in vitro. Next, we compared the capability of bone marrow-derived mesenchymal stem cells (BM-MSCs) as an alternative accessible cell source to BlCs for regeneration of appendages...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105392/mouse-bone-marrow-derived-mast-cells-induce-angiogenesis-by-tissue-engineering-in-rats-histological-evidence
#12
Ali Karimi, Rasoul Shahrooz, Rahim Hobbenaghi, Rahim Mohammadi, Esmaeil Mortaz
OBJECTIVES: Therapeutic angiogenesis is employed to induce vascular network formation and improve functional recovery in ischemia. The aim of this study is to find an appropriate method to recover local ischemic conditions. MATERIALS AND METHODS: In this experimental survey, 20 male Wistar rats weighing approximately 200-250 g were randomly divided into four experimental groups respectively: ischemia group in which the femoral artery was transected; phosphate buffer solution group (PBS) in which the femoral artery transected location was immersed with PBS; chitosan (CHIT) group in which the transected location was immersed in a 50 μL CHIT solution; and mast cell transplanted group in which the transected location was immersed with a mixture of 50 μL CHIT and 50 μL PBS that contained 1×10(6) mast cells...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105391/the-molecular-chaperone-artemin-efficiently-blocks-fibrillization-of-tau-protein-in-vitro
#13
Zahra Khosravi, Mohammad Ali Nasiri Khalili, Sharif Moradi, Reza Hassan Sajedi, Mehdi Zeinoddini
OBJECTIVES: Aggregation of the TAU proteins in the form of neurofibrillary tangles (NFTs) in the brain is a common risk factor in tauopathies including Alzheimer's disease (AD). Several strategies have been implemented to target NFTs, among which chaperones, which facilitate the proper folding of proteins, appear to hold great promise in effectively inhibiting TAU polymerization. The aim of this study was to analyze the impact of the chaperone Artemin on TAU aggregation in vitro. MATERIALS AND METHODS: In this experimental study, recombinant TAU- or Artemin proteins were expressed in E...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105390/dual-effects-of-cell-free-supernatants-from-lactobacillus-acidophilus-and-lactobacillus-rhamnosus-gg-in-regulation-of-mmp-9-by-up-regulating-timp-1-and-down-regulating-cd147-in-pmadifferentiated-thp-1-cells
#14
Faezeh Maghsood, Abbas Mirshafiey, Mohadese M Farahani, Mohammad Hossein Modarressi, Parvaneh Jafari, Elahe Motevaseli
OBJECTIVES: Recent studies have reported dysregulated expression of matrix metalloproteinases (MMPs), especially MMP-2, MMP-9, tissue inhibitor of metalloproteinase-1, -2 (TIMP-1, TIMP-2), and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in activated macrophages of patients with inflammatory diseases. Therefore, MMP-2, MMP-9, and their regulators may represent a new target for treatment of inflammatory diseases. Probiotics, which are comprised of lactic acid bacteria, have the potential to modulate inflammatory responses...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105389/determination-of-the-properties-of-rat-brain-thermostable-protein-complex-which-inhibit-cell-proliferation
#15
Diana Dzidziguri, Irina Modebadze, Ekaterine Bakuradze, Giorgi Mosidze, Manana Berulava
OBJECTIVES: Cell proliferation is known to be controlled by many networks of regulatory proteins. These multiple and complicated mechanisms of control are still being investigated. The aim of the present study is to determine the different properties of adult rat brain thermostable protein complex (TPC) which affect cell proliferation. MATERIALS AND METHODS: This experimental study used brain, kidney and liver tissue from adult (150-170 g) and adolescent (7, 10, 21, 28 days) white rats, adult pigeons and mice...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105388/in-vitro-differentiation-of-neural-like-cells-from-human-embryonic-stem-cells-by-a-combination-of-dorsomorphin-xav939-and-a8301
#16
Zahra Valizadeh-Arshad, Ebrahim Shahbazi, Shiva Hashemizadeh, Azadeh Moradmand, Meyssam Jangkhah, Sahar Kiani
OBJECTIVES: Motor neuron differentiation from human embryonic stem cells (hESCs) is a goal of regenerative medicine to provide cell therapy as treatments for diseases that damage motor neurons. Most protocols lack adequate efficiency in generating functional motor neurons. However, small molecules present a new approach to overcome this challenge. The aim of this research is to replace morphogen factors with a cocktail of efficient, affordable small molecules for effective, low cost motor neuron differentiation...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105387/in-vitro-effects-of-wistar-rat-prenatal-and-postnatal-cerebrospinal-fluid-on-neural-differentiation-and-p-roliferation-of-mesenchymal-stromal-cells-derived-from-bone-marrow
#17
Rozmehr Shokohi, Mohammad Nabiuni, Saeed Irian, Jaleel A Miyan
OBJECTIVES: Cerebrospinal fluid (CSF) plays an important role in cortical development during the fetal stages. Embryonic CSF (E-CSF) consists of numerous neurotrophic and growth factors that regulate neurogenesis, differentiation, and proliferation. Mesenchymal stem cells (MSCs) are multi-potential stem cells that can differentiate into mesenchymal and non-mesenchymal cells, including neural cells. This study evaluates the prenatal and postnatal effects of CSF on proliferation and neural differentiation of bone marrow MSCs (BM-MSCs) at gestational ages E19, E20, and the first day after birth (P1)...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105386/the-effect-of-ethanolic-extract-of-lippia-citriodora-on-rats-with-chronic-constriction-injury-of-neuropathic-pain
#18
Bahareh Amin, Reyhaneh Noorani, Bibi Marjan Razavi, Hossein Hosseinzadeh
OBJECTIVES: We examined the protective effects of ethanolic extract of Lippia citriodora (L. citriodora) on rats subjected to chronic constriction injury (CCI) of sciatic nerve and possible mechanisms of actions. MATERIALS AND METHODS: In this experimental study, the extract was administered 50, 100 and 200 mg/kg, Intraperitoneally (I.P) from the surgery time for 14 consecutive days. The changes in the spinal cord levels of apoptotic factors, microglia and astroglia markers during the time course of study were assessed by western blotting on days 3, 7 and 14 post-CCI...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29105385/punica-granatum-l-fruit-aqueous-extract-suppresses-reactive-oxygen-species-mediated-p53-p65-mir-145-expressions-followed-by-elevated-levels-of-irs-1-in-alloxan-diabetic-rats
#19
Ehsan Gharib, Shideh Montasser Kouhsari, Maryam Izad
OBJECTIVES: Reactive oxygen species (ROS) is an apoptosis inducer in pancreatic β-cells that stimulates p53/p65 mediated microRNA (miR)-145 expression. Punica granatum L. (pomegranate) is an antioxidant fruit that attenuates ROS generation. This study examines the effects of pomegranate fruit aqueous extract (PGE) on the levels of ROS, p53, p65, miR-145, and its target insulin receptor substrate 1 (irs-1) mRNA in Alloxan-diabetic male Wistar rats. MATERIALS AND METHODS: In this experimental study, diabetic rats received different doses of PGE...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/28836414/taraxerol-induces-cell-apoptosis-through-a-mitochondria-mediated-pathway-in-hela-cells
#20
Xiangyang Yaoi, Binyu Lu, Chaotian Lü, Qin Bai, Dazhong Yan, Hui Xu
OBJECTIVES: Taraxerol acetate has potent anti-cancer effects via the induction of apoptosis, autophagy, cell cycle arrest, and inhibition of cell migration. However, whether taraxerol induced apoptosis and its underlying mechanisms of action is not clear. In the present study, we assess the effects of taraxerol on the mitochondrial apoptotic pathway and determine the release of cytochrome c to the cytosol and activation of caspases. MATERIALS AND METHODS: In this experimental study, we mainly investigated the effect of taraxerol on HeLa cells...
October 2017: Cell Journal
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