journal
https://read.qxmd.com/read/38408794/opioid-toxicity-after-oxycodone-naloxone-to-oxycodone-conversion-case-series
#21
JOURNAL ARTICLE
Mairead Doherty, Hannah Joan Featherstone, Clare McAleer, Chloe Webb, Maeve O'Reilly, Marie Twomey, Regina McQuillan
Combination preparations of oxycodone/naloxone are marketed to aid in the management of opioid induced bowel dysfunction, with caution advised in prescribing in cases of liver dysfunction.This case series demonstrates four cases of patients with normal liver function tests who developed significant opioid toxicity on conversion from combination oxycodone/naloxone to oxycodone at equivalent doses, necessitating significant dose reduction.In each case, a cause for intra-hepatic shunting such as cirrhosis, porto-systemic collaterals or thrombosis were identified, highlighting these as cautionary features when prescribing combination preparations of oxycodone/naloxone and the possible need for dose reduction if converting to oxycodone...
February 26, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38395600/palliative-care-screening-tools-in-japan-cross-sectional-utility-study
#22
JOURNAL ARTICLE
Mami Minato, Youkie Shiozawa, Shintaro Kosaka, Masaya Higuchi, Kei Ouchi
OBJECTIVES: In Japan's ageing society, the utility of US-based and UK-based palliative care screening tools in the inpatient setting is unknown. The purpose of this study is to identify the unmet palliative care needs of patients who are admitted to an acute care hospital using the US-based and UK-based screening tools. METHODS: This single-centre, cross-sectional study included patients who were admitted to an acute care hospital in Tokyo, Japan, from November 2019 to January 2020...
February 23, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38395599/new-uk-palliative-medicine-consultants-clinical-and-non-clinical-preparedness-after-higher-specialty-training
#23
JOURNAL ARTICLE
Sarika Hanchanale, Amara Callistus Nwosu, Jason W Boland
OBJECTIVES: Higher specialty trainees are expected to achieve clinical and non-clinical skills during training in preparation for a consultant role. However, evidence from many specialties from different countries suggests that new consultants are less prepared in non-clinical skills. The transition from trainee to a consultant phase can be challenging. The study aims to identify if new UK Palliative Medicine consultants, within 5 years of their appointment, feel prepared in clinical and non-clinical skills after completing specialty training and understand the support available for them...
February 23, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38395598/assisted-deaths-in-switzerland-for-uk-residents-diagnoses-and-their-implications-for-palliative-medicine-and-assisted-dying-legislation
#24
JOURNAL ARTICLE
Colin Brewer, Marie-Claire Hopwood, Graham Winyard
OBJECTIVE: UK campaigners for a law permitting assisted dying (AD) restricted to those with a maximum life expectancy of 6 months claim that this would largely remove the need for UK residents to seek AD in Switzerland. We wanted to discover whether this prediction was correct. METHODS: We analysed the diagnoses of UK residents who had such deaths including, for the first time, data from all three of the main Swiss providers of AD to non-residents, comparing them with figures from Oregon, which has a 6-month restriction...
February 23, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38395597/fluid-retention-and-weight-loss-in-refractory-cancer-cachexia
#25
JOURNAL ARTICLE
Koji Amano, Satomi Okamura, Vickie Baracos, Naoharu Mori, Tatsuma Sakaguchi, Yu Uneno, Yusuke Hiratsuka, Jun Hamano, Tomofumi Miura, Hiroto Ishiki, Naosuke Yokomichi, Yutaka Hatano, Tatsuya Morita, Masanori Mori
OBJECTIVES: It is unknown to what extent the fluid retention (FR) status disrupts the detection of weight loss rate (WLR) in adult patients with advanced cancer. This study aimed to determine the association of FR status with WLR. METHODS: This study was a secondary analysis of a prospective cohort study. FR was evaluated as follows: oedema (0, no; 1, yes), pleural effusion (0, no; 1, yes but asymptomatic; 2, symptomatic) and ascites (0, no; 1, yes but asymptomatic; 2, symptomatic)...
February 23, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38395596/procalcitonin-in-advanced-urological-cancer-bacterial-versus-non-bacterial-infections-prospective-cohort-study
#26
JOURNAL ARTICLE
Hiroshi Yaegashi, Kouji Izumi, Ren Toriumi, Shuhei Aoyama, Taiki Kamijima, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Hiroaki Iwamoto, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Atsushi Mizokami
OBJECTIVES: Patients with advanced cancer may develop bacterial infections (BI) as their general condition worsens, but general blood tests often find it difficult to distinguish them from non-bacterial infections (NBI). The present prospective study was undertaken to investigate the effectiveness of serum procalcitonin levels in distinguishing between BI and NBI in patients with advanced urological cancer. METHODS: This study prospectively evaluated patients diagnosed with locally advanced or metastatic or recurrent urological cancer in our department from September 2013 to December 2019...
February 23, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38388211/early-palliative-care-in-haematological-malignancies
#27
EDITORIAL
Leonardo Potenza, Mario Luppi, Camilla Zimmermann, Elena Bandieri
No abstract text is available yet for this article.
February 22, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38388210/burnout-and-attachment-in-oncology-and-palliative-care-healthcare-professionals
#28
JOURNAL ARTICLE
Florbela Gonçalves, Margarida Gaudencio, Miguel Castelo Branco, Joaquim Viana
OBJECTIVES: Examine the prevalence of burn-out in health professionals working in a hospital dedicated to patients with cancer. Explore the relationship between attachment style and burn-out in healthcare professionals working in Oncology and Palliative Care. METHODS: Cross-sectional descriptive and correlational study with a sample of 337 health professionals working in a tertiary hospital dedicated to oncology care. The evaluation protocol included a sociodemographic questionnaire, two burn-out (Copenhagen Burnout Inventory (CBI) and Maslach Burnout Inventory) and attachment (Adult Attachment Scale) scales...
February 22, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38388209/sedation-from-analgesics-patient-preference-survey
#29
JOURNAL ARTICLE
Joseph Burdon, Samuel Fingas, Rachel Parry, Constantina Pitsillides, Paul Taylor
BACKGROUND: The propensity for certain analgesics to cause sedation is well documented, yet physician-patient dialogue does not routinely include pre-emptive exploration of preferences regarding this side effect. OBJECTIVES: To investigate the extent to which palliative patients would accept sedation as a side effect of analgesia and to identify factors affecting decision-making. METHODS: Patients (n=76) known to a specialist palliative care services were given hypothetical scenarios regarding pain and asked about the acceptability of varying levels of sedation occurring as an analgesic side effect...
February 22, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38383059/subcutaneous-lacosamide-for-seizures
#30
JOURNAL ARTICLE
Natalie McCarthy, Elizabeth Freshwater, Nial McCarron
The management of seizures at the end of life is vital for patient comfort and to reduce carer distress. The use of high -dose subcutaneous benzodiazepines is standard, but not always effective. We present a case where lacosamide was used subcutaneously to prevent seizure activity.
February 21, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38378244/palliative-radiotherapy-survival-prognostic-factors-single-centre-retrospective-cohort-study
#31
JOURNAL ARTICLE
Sian Cooper, Mary Denholm, Abdul Shawal Malek, Jeffrey Arun Rubasingham, David Tsang
OBJECTIVE: Patients with non-curative malignancy can receive palliative radiotherapy (PR) to alleviate symptoms. However, choosing the right patient to receive PR can be challenging, as some patients may not survive long enough to gain benefit. This study aims to identify prognostic factors for overall survival (OS) and 30-day mortality (30DM) following PR and to test these in a real-world cohort. METHOD: A retrospectively collected data set of all adults completing PR between 1 August 2018 and 31 December 2018 at a single centre (n=214, Southend University Hospital NHS Foundation Trust, UK) was used to test prognostic factors...
February 20, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38378243/hospital-based-palliative-care-referrals-determinants-in-older-adults-with-cancer
#32
JOURNAL ARTICLE
Alex Chanteclair, Sophie Duc, Brice Amadeo, Gaelle Coureau, Pierre Soubeyran, Simone Mathoulin-Pelissier, Karine Peres, Catherine Helmer, Angeline Galvin, Matthieu Frasca
OBJECTIVES: Early palliative care improves the quality of life of older patients with cancer. This work aimed to analyse the effect of sociodemographic, geriatric, and tumour-related determinants on hospital-based palliative care (HPC) referral in older patients with cancer, taking into account competing risk of death. METHODS: Older adults with diagnosed cancer from 2014 to 2018 according to the general cancer registry of Gironde (French department) were identified in three population-based cohorts on ageing (PAQUID, 3C - Three City, AMI)...
February 20, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38378242/personalised-virtual-reality-in-palliative-care-clinically-meaningful-symptom-improvement-for-some
#33
JOURNAL ARTICLE
Kaylin Altman, Dimitrios Saredakis, Hannah Keage, Amanda Hutchinson, Megan Corlis, Ross T Smith, Gregory Brian Crawford, Tobias Loetscher
OBJECTIVES: This study examined the effects of virtual reality (VR) among palliative care patients at an acute ward. Objectives included evaluating VR therapy benefits across three sessions, assessing its differential impact on emotional versus physical symptoms and determining the proportion of patients experiencing clinically meaningful improvements after each session. METHODS: A mixed-methods design was employed. Sixteen palliative inpatients completed three personalised 20 min VR sessions...
February 20, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38326015/health-literacy-interventions-for-informal-caregivers-systematic-review
#34
JOURNAL ARTICLE
Eva Yuen, Carlene Wilson, Joanne Adams, Tejashree Kangutkar, Patricia M Livingston, Victoria M White, Cherene Ockerby, Alison Hutchinson
AIM: The aim of the systematic review was to identify conceptual models and interventions designed to improve health literacy in caregivers of adults with a chronic disease/disability. METHODS: MEDLINE, CINAHL, PsycINFO and Embase were searched for relevant literature. Articles were included if they focused on adults who provided informal care to someone aged 18+ with a chronic disease/disability. Quantitative studies were included if they reported an intervention designed to improve caregiver health literacy (CHL) and assessed outcomes using a validated measure of health literacy...
February 7, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38326014/oxaliplatin-related-dysphagia-mixed-methods-study
#35
JOURNAL ARTICLE
Ciarán Kenny, Julie Regan, Lucy Balding, Stephen Higgins, Norma O'Leary, Fergal Kelleher, Ray McDermott, John Armstrong, Alina Mihai, Eoin Tiernan, Jennifer Westrup, Pierre Thirion, Declan Walsh
OBJECTIVES: To evaluate participant-reported atypical dysphagia symptoms and their association with oxaliplatin treatment. METHODS: This observational study recruited 73 adults with solid tumours outside the head, neck or upper gastrointestinal tract. All had dysphagia, were in hospital or hospice and were treated by Medical Oncology, Radiation Oncology or Palliative Care. Participants reported their experiences of swallowing difficulties by semistructured interview...
February 7, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38316516/the-physician-surprise-question-in-the-emergency-department-prospective-cohort-study
#36
JOURNAL ARTICLE
Sabrina Correa Costa Ribeiro, Thiago Augusto Arantes Lopes, Jose Victor Gomes Costa, Caio Godoy Rodrigues, Ian Ward Abdalla Maia, Lucas de Moraes Soler, Julio Flavio Meirelles Marchini, Rodrigo Antônio Brandão Neto, Heraldo Possolo Souza, Júlio César Garcia Alencar
OBJECTIVES: This study aims to test the ability of the surprise question (SQ), when asked to emergency physicians (EPs), to predict in-hospital mortality among adults admitted to an emergency room (ER). METHODS: This prospective cohort study at an academic medical centre included consecutive patients 18 years or older who received care in the ER and were subsequently admitted to the hospital from 20 April 2018 to 20 October 2018. EPs were required to answer the SQ for all patients who were being admitted to hospital...
February 5, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38307704/introducing-palliative-care-in-advanced-cancer-a-systematic-review
#37
JOURNAL ARTICLE
Samuel Pointon, Anna Collins, Jennifer Philip
BACKGROUND: Negative perceptions about palliative care (PC), held by patients with cancer and their families, are a barrier to early referral and the associated benefits. This review examines the approaches that support the task of introducing PC to patients and families and describes any evaluations of these approaches. METHODS: A systematic review with a systematic search informed by the Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines was performed on the online databases MEDLINE, PsychInfo and CINAHL from May 2022 to July 2022...
February 2, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38307703/cannabinol-oil-or-placebo-in-advanced-cancer-disease-progression-and-survival-a-secondary-analysis
#38
JOURNAL ARTICLE
Cian O'Leary, Ristan Greer, Georgie Huggett, Phillip Good, Taylan Gurgenci, Janet Hardy
OBJECTIVES: Medical cannabinoids have become increasingly popular over the last decade. Preclinical trials suggest cannabinoids, for example, cannabidiol (CBD), may provide an anticancer effect; however, good-quality clinical information supporting this is lacking. We assessed the effect of CBD treatment on disease progression and survival in patients enrolled in a study of CBD versus placebo for symptom management in patients with advanced cancer (MEDCAN-1). METHODS: We reviewed the clinical records of all patients enrolled in the MEDCAN-1 Study (CBD vs placebo) at days 14, 28 and 56 of study follow-up, for evidence of disease progression...
February 2, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38302255/optimizing-quality-of-life-integrating-palliative-care-for-patients-with-hand-foot-syndrome-in-oncology-practice
#39
JOURNAL ARTICLE
Divya Sai Vanumu, Praveen Kumar Kodisharapu, Praneeth Suvvari, Basanth Kumar Rayani, Nikhil Pathi, Rohan Tewani, Senthil J Rajappa
Hand-foot syndrome (HFS) emerges as one of the common dermatological side effects associated with anticancer medications such as 5-fluorouracil (5-FU), capecitabine and docetaxel. This condition can be notably debilitating, exerting a predominant impact on the clinical, functional and psychosocial domains of health. With prevalence rates of HFS, ranging from 43% to 71%, there exists an unmet need among palliative care physicians to comprehend this syndrome in addressing physical, psychological dimensions and its integrated management within healthcare...
February 1, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38302254/medical-cannabis-and-total-pain-in-a-cancer-population
#40
LETTER
Tzeela Cohen, Simon Wein
No abstract text is available yet for this article.
February 1, 2024: BMJ Supportive & Palliative Care
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