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World Journal of Oncology

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https://www.readbyqxmd.com/read/29760836/concomitant-atm-mutations-identified-by-next-generation-sequencing-in-a-patient-with-new-onset-acute-myeloid-leukemia-following-imatinib-treatment-for-chronic-myeloid-leukemia
#1
Matthew K Stein, Melissa Crawley, Eric Vick, Mike G Martin
No abstract text is available yet for this article.
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29760835/cutaneous-mucormycosis-following-a-bullous-pemphigoid-flare-in-a-chronic-lymphocytic-leukemia-patient-on-ibrutinib
#2
Matthew K Stein, Saradasri Karri, Jackson Reynolds, Jeff Owsley, Austin Wise, Mike G Martin, Fereshteh Zare
While the recent development of novel therapeutics in oncology, such as small molecule kinase inhibitors (SMKIs), has enabled our ability to target disease-specific molecular pathways, the prolonged impact of these agents on the immune system and infectious risk remains to be seen. We present a 68-year-old male with refractory chronic lymphocytic leukemia (CLL) on ibrutinib monotherapy for 3 years who developed extensive cutaneous mucormycosis following a severe bullous pemphigoid (BP) flare. He received amphotericin B for 4 weeks and was continued on posaconazole with resolution of his mucormycosis infection...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29760834/a-case-series-of-two-patients-presenting-with-pericardial-effusion-as-first-manifestation-of-non-small-cell-lung-cancer-with-braf-mutation-and-expression-of-pd-l1
#3
Muhammad Mufti, Steven Ching, Sassan Farjami, Sharareh Shahangian, Serap Sobnosky
Lung cancer is the number one cause of cancer-related deaths in the United States. Involvement of pericardium occurs once cancer has progressed to stage IV which can cause massive effusion in the pericardial sac. This can lead to cardiac tamponade which can be fatal very quickly if untreated. The following is a two patient case series in which both patients presented with large pericardial effusion. The first patient sought medical attention due to new onset palpitations and was found to have hemorrhagic pericardial effusion and pulmonary embolism (PE)...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29760833/synchronous-presence-of-egfr-alk-driver-mutations-along-with-pd-l1-overexpression-in-a-resected-early-stage-non-small-cell-lung-cancer-a-case-report-and-review-of-literature
#4
Nishitha Thumallapally, Sara Parylo, Adarsh Vennepureddy, Uroosa Ibrahim, Alisa Sokoloff
Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged citing the presence of both mutations either synchronously or metachronously. We describe a case report of lung adenocarcinoma harboring two driver mutations in the same tumor cells as well as exhibiting high PDL1 expression. We further discuss the possible association of these driver mutations with PDL1 expression...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29760832/impact-of-provider-volume-on-outcomes-of-patients-with-hodgkin-lymphoma
#5
Catherine Ireland, Eric Wiedower, Muhammad Mirza, Melissa Crawley, Alexandria Tran, George Yaghmour, Mike G Martin
Background: While the provider volume-outcome relationship has been established for many complex surgeries and invasive procedures, the provider volume impact on outcomes for Hodgkin lymphoma (HL) is less certain. We hypothesized that high-volume providers (HVPs) may have superior outcomes compared with low-volume providers (LVPs). Methods: We performed a chart-based, retrospective review of all patients receiving adriamycin, doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) for HL at the West Cancer Center from January 2010 to June 2015...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29760831/current-status-of-organ-preservation-in-carcinoma-larynx
#6
REVIEW
Tapesh Bhattacharyya, Cessal Thommachan Kainickal
Organ preservation in carcinoma larynx is a long debated topic. There are multiple organ preserving approaches in the management of carcinoma larynx depending on various factors. Radical radiotherapy (RT) and conservation laryngeal surgery have shown equivalent results in early laryngeal cancer. Concurrent chemoradiation (CTRT) is the standard treatment in stage III and IV laryngeal cancer with intact cartilage and functional larynx. Patients with cartilage destruction or dysfunctional larynx are not the candidates for organ preservation...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581814/a-rare-case-of-colonic-metastases-from-tonsillar-carcinoma-case-report-and-review-of-literature
#7
Hassan Tariq, Muhammad Umar Kamal, Shehriyar Mehershahi, Muhammad Saad, Sara Azam, Kishore Kumar, Masooma Niazi, Jasbir Makker, Myrta Daniel
The incidence of tonsillar cancer has increased by four times in the United States over the last few decades likely due to recent increase in human papilloma virus (HPV) infections. The stage of the tumor predicts likelihood of metastasis, with advanced stages associated with higher chances of metastasis. The squamous cell carcinomas (SCCs) of the head and neck commonly metastasize to the lung, bone and liver in descending order. Tonsillar cancer rarely involves the small bowel and our review of the literature did not reveal any reported case of metastasis to the colon/large bowel...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581813/atypical-presentation-of-acute-myeloid-leukemia
#8
Kavita Agrawal, Levin Miles, Nirav Agrawal, Asim Khan
We present a case of a 48-year-old male who presented with worsening pleuritic chest pain for 2 h. He also complained of fever, malaise, headache and severe neck pain. Electrocardiogram (ECG) showed ST segment elevation in leads I, II, aVL and V5 with PR elevation and ST depression in aVR. On admission, troponin-I was 14.8 ng/mL. Based on ECG changes, elevated troponin and family history of early coronary artery disease, the patient was emergently taken to cardiac catheterization lab. Angiography showed non-obstructive coronaries, mild hypokinesis of mid inferior and anterolateral wall with ejection fraction (EF) of 40-45%...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581812/inhibition-of-erk1-2-or-akt-activity-equally-enhances-radiation-sensitization-in-b16f10-cells
#9
Bhuvanesh Sukhlal Kalal, Faraz Fathima, Vinitha Ramanath Pai, Ganesh Sanjeev, Chilakapati Murali Krishna, Dinesh Upadhya
Background: The aim of the study was to evaluate the radiation sensitizing ability of ERK1/2, PI3K-AKT and JNK inhibitors in highly radiation resistant and metastatic B16F10 cells which carry wild-type Ras and Braf . Methods: Mouse melanoma cell line B16F10 was exposed to 1.0, 2.0 and 3.0 Gy of electron beam radiation. Phosphorylated ERK1/2, AKT and JNK levels were estimated by ELISA. Cells were exposed to 2.0 and 3.0 Gy of radiation with or without prior pharmacological inhibition of ERK1/2, AKT as well as JNK pathways...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581811/lymphocyte-to-monocyte-ratio-and-modified-glasgow-prognostic-score-predict-prognosis-of-lung-adenocarcinoma-without-driver-mutation
#10
Seigo Minami, Shouichi Ihara, Sung-Ho Kim, Suguru Yamamoto, Kiyoshi Komuta
Background: Neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) and modified Glasgow prognostic score (mGPS) are useful prognostic markers based on host-related systemic inflammatory response. They have been shown as independent prognostic biomarkers in various cancers, including non-small cell lung cancer. However, there has been little evidence for a specific population of pulmonary adenocarcinoma without active epidermal growth factor receptor (EGFR) mutation. Methods: We retrospectively reviewed 159 patients who met the following criteria: histologically or cytologically diagnosed adenocarcinoma, confirmed wild-type EGFR, started first-line cytotoxic chemotherapy between July 2007 and March 2017 at our hospital, and c-stage IIIB or IV...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581810/the-clinical-efficacy-of-prostate-cancer-screening-in-worldwide-and-iran-narrative-review
#11
REVIEW
Shima Shahyad, Seyed Hassan Saadat, Seyed-Mostafa Hosseini-Zijoud
Prostate cancer (CaP) imposes a great health burden on men, while its incidence has significantly increased in recent years. The screening program for CaP is still controversial and recent large trials have failed to present a significant reduction in prostate-specific mortality and all-cause mortality. An entire body of data obtained from worldwide studies conducted on CaP screening is required to better evaluate health policy decisions and patient decision-making. In current review, the clinical efficacy of screening programs on CaP was discussed in numerous parts of the world, such as in the US, Europe, and Asia, to provide an updated screening recommendation...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581809/autoimmune-diabetes-associated-with-pembrolizumab-a-review-of-published-case-reports
#12
REVIEW
Anmol Cheema, Bhaktidevi Makadia, Tejas Karwadia, Ravneet Bajwa, Mohammad Hossain
The utility of immunotherapy, such as pembrolizumab, is becoming essential in the treatment of certain cancers. Pembrolizumab works through binding of programmed cell death 1 receptor that blocks the binding of the programmed cell death ligand 1 and is commonly used in non-small cell lung cancer and melanoma. Pembrolizumab has been reported to be associated with multiple adverse reactions such as pneumonitis, colitis, hepatitis, hypophysitis, hyperthyroidism, hypothyroidism, nephritis, and type 1 diabetes; however, pembrolizumab causing type 1 diabetes was only reported in 0...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29319059/retraction-notice-to-repeated-multiple-neurofibromatosis-type-1-in-the-right-lower-limb-a-case-report
#13
(no author information available yet)
[This retracts the article DOI: 10.14740/wjon1011w.].
December 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29317966/epithelioid-angiosarcoma-in-femur-a-case-presentation
#14
Yunus Oc, Bekir Eray Kilinc, Rodi Ertugrul, Hasan Basri Sezer, Osman Tugrul Eren
Primary malignant vascular tumors which constitute less than 1% of the primary bone tumors are very rarely encountered. Epithelioid angiosarcoma is a very uncommon subtype of angiosarcomas presenting with an epithelioid phenotype and mimicking carcinomas clinically. These tumors select mostly extra-skeletal locations but rarely bones as their medium. A 31-year-old male patient applied to our clinic with a nonspecific left hip pain. X-ray evaluation revealed a cystic expansile mass in the trochanteric region of the femur extending to the femoral neck...
December 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29317965/perioperative-anesthetic-management-of-a-case-of-rare-ectopic-pheochromocytoma
#15
Aihua Jiang, Haiqiao Zhang, Xiaofei Liu, Huishan Zhao
We report an unusual case of pheochromacytoma and investigate the perioperative anesthetic management methods for giant abdominal aortic pheochromocytoma. We analyzed and summarized the recent clinical anesthetic management and experience in the hospital for a giant abdominal aortic pheochromocytoma, with the size of 20 × 14 × 5 cm. Under general anesthesia combined with TAPB, the resection of the giant abdominal aorta pheochromocytoma was successfully completed, and the patient was cured and discharged. Well planned and careful management resulted in patient with stable blood pressure, blood volume and cardiac functions, free from complications...
December 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29317964/basaloid-squamous-cell-carcinoma-of-the-lung-associated-with-syndrome-of-inappropriate-antidiuretic-hormone-secretion
#16
Ashraf Abugroun, Fatima Ahmed, Toni-Denise Espina, Alvaro Altamirano Ufion
Basaloid squamous cell carcinoma (BSQCC) of the lung is a very rare subtype of squamous cell carcinoma (SCC). There have been no reported cases of syndrome of inappropriate anti-diuretic hormone secretion (SIADH) developing concurrently with this tumor. We herein present a case of a 68-year-old female who was diagnosed with lung mass discovered incidentally on preoperative clearance for surgical fixation of right humeral neck fracture. The patient presented to the hospital with nausea, vomiting, diarrhea and fatigue...
December 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29317963/neutrophil-to-lymphocyte-ratio-predicts-overall-survival-of-advanced-non-small-cell-lung-cancer-harboring-mutant-epidermal-growth-factor-receptor
#17
Seigo Minami, Yoshitaka Ogata, Shouichi Ihara, Suguru Yamamoto, Kiyoshi Komuta
Background: Neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) have been demonstrated to be prognostic biomarkers in various cancers, including non-small cell lung cancer (NSCLC). However, little has been known about these two ratios for a specific population of NSCLC harboring active epidermal growth factor receptor (EGFR) mutation. Methods: We retrospectively reviewed electrical medical records of 152 patients who met the following criteria: NSCLC harboring mutant EGFR, EGFR-tyrosine kinase inhibitor (EGFR-TKI) monotherapy initiated between October 2007 and February 2017 at our hospital, stage III-IV or post-surgical recurrence...
December 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29317962/combination-of-advanced-lung-cancer-inflammation-index-and-c-reactive-protein-is-a-prognostic-factor-in-patients-with-operable-non-small-cell-lung-cancer
#18
Masaki Tomita, Takanori Ayabe, Ryo Maeda, Kunihide Nakamura
Background: Previous study of ours showed that advanced lung cancer inflammation index (ALI) and C-reactive protein (CRP) are independent significant prognostic factors in operable non-small cell lung cancer (NSCLC) patients. Since both ALI and CRP are markers of inflammation, the aim of this study was to examine whether the combination of ALI and CRP is a prognostic indicator of resected NSCLC or not. Methods: Three hundred forty-one NSCLC patients who underwent surgery at our institution between 2008 and 2012 were included...
December 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29149224/correction-evaluation-of-acute-toxicity-and-early-clinical-outcome-in-head-and-neck-cancers-treated-with-conventional-radiotherapy-and-simultaneous-integrated-boost-arc-radiotherapy
#19
Amit Bahl, Arun S Oinam, Satinder Kaur, Roshan Verma, Arun Elangovan, Sudhir Bhandari, Jaimanti Bakshi, Naresh Panda, Sushmita Ghoshal
[This corrects the article DOI: 10.14740/wjon1049w.].
October 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29147454/late-onset-chemo-radiation-induced-tracheoesophageal-fistula-in-squamous-cell-cancer-of-the-lung
#20
Ashraf Abugroun, Fatima Ahmed, Namrata Singh, Mojtaba Nadiri
We report a 72-year-old male with past medical history of stage IV squamous lung cancer treated with radiation therapy and chemotherapy with gemcitabine/carboplatin. One year later, he presented with hemoptysis treated with another session of palliative radiotherapy. Two weeks later, patient developed aspiration pneumonia and further workup showed trachea-esophageal fistula documented by barium swallow. This case shows a rare complication of chemotherapy and radiation therapy on the setting of primary lung cancer...
October 2017: World Journal of Oncology
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