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BioImpacts: BI

Morteza Mahmoudi, Mingming Zhao, Yuka Matsuura, Sophie Laurent, Phillip C Yang, Daniel Bernstein, Pilar Ruiz-Lozano, Vahid Serpooshan
Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium. By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch...
2016: BioImpacts: BI
Babak Nami, Armin Ghasemi-Dizgah, Akbar Vaseghi
INTRODUCTION: Breast cancer stem cell with CD44(hi)/CD24(lo) phonotype is described having stem cell properties and represented as the main driving factor in breast cancer initiation, growth, metastasis and low response to anti-cancer agents. Glucoseregulated proteins (GRPs) are heat shock protein family chaperons that are charged with regulation of protein machinery and modulation of endoplasmic reticulum homeostasis whose important roles in stem cell development and invasion of various cancers have been demonstrated...
2016: BioImpacts: BI
Mohammad Amir Amirkhani, Rashin Mohseni, Masoud Soleimani, Alireza Shoae-Hassani, Mohammad Ali Nilforoushzadeh
INTRODUCTION: Much attention has been paid to the idea of cell therapy using stem cells from different sources of the body. Fat-derived stem cells that are called adipose derived stem cells (ADSCs) from stromal vascular fraction (SVF) are the subject of many studies in several cell therapy clinical trials. Despite production of some GMP-grade enzymes to isolate SVF for clinical trials, there are critical conditions like inconsistency in lot-to-lot enzyme activity, endotoxin residues, other protease activities and cleavage of some cell surface markers which significantly narrow the options...
2016: BioImpacts: BI
Jalil Pirayesh Islamian, Mohsen Mohammadi, Behzad Baradaran, Alireza Farajollahi, Seyed Mahmoud Reza Aghamiri, Mohammad Asghari Jafarabadi, Hadi Karami, Amir Monfaredan, Dariush Shanehbandi
INTRODUCTION: Human double minute2 (hdm2) level increases in most human malignancies. Therefore, inhibition of tumor growth and also induction of radiosensitivity may be provided by hdm2 inhibitors. The effects of hdm2-siRNA on hdm2 protein expression, cell apoptosis rate, and radiosensitivity of human esophageal squamous cell carcinoma (ESCC) were studied. METHODS: The hdm2 gene was silenced in TE1, TE8, and TE11 ESCC cell lines using 200nM siRNA by liposomal transfection method followed by irradiation with 0...
2016: BioImpacts: BI
Mohammad Salimi-Asl, Hossein Mozdarani, Mehdi Kadivar
INTRODUCTION: Polycystic ovary syndrome (PCOS), a multigenic endocrine disorder, is highly associated with low-grade chronic inflammation, however its etiology remains unclear. In this study, we employed dehydroepiandrosterone (DHEA)-treated mice to reveal the molecular mechanism of inflammation and its correlation with oxidative stress in PCOS patients. METHODS: miR-21 and miR-146a expression levels were measured using quantitative real-time polymerase chain reaction (qRT-PCR)...
2016: BioImpacts: BI
Mina Hosseinpour, Vahid Azimirad, Maryam Alimohammadi, Parviz Shahabi, Mina Sadighi, Ghazaleh Ghamkhari Nejad
INTRODUCTION: Carbon nanotubes (CNTs) are novel candidates in nanotechnology with a variety of increasing applications in medicine and biology. Therefore the investigation of nanomaterials' biocompatibility can be an important topic. The aim of present study was to investigate the CNTs impact on cardiac heart rate among rats. METHODS: Electrocardiogram (ECG) signals were recorded before and after injection of CNTs on a group with six rats. The heart rate variability (HRV) analysis was used for signals analysis...
2016: BioImpacts: BI
Reza Safdari, Reza Ferdousi, Kamal Aziziheris, Sharareh R Niakan-Kalhori, Yadollah Omidi
INTRODUCTION: Health care industry also patients penalized by medical errors that are inevitable but highly preventable. Vast majority of medical errors are related to adverse drug reactions, while drug-drug interactions (DDIs) are the main cause of adverse drug reactions (ADRs). DDIs and ADRs have mainly been reported by haphazard case studies. Experimental in vivo and in vitro researches also reveals DDI pairs. Laboratory and experimental researches are valuable but also expensive and in some cases researchers may suffer from limitations...
2016: BioImpacts: BI
Mohammad A Rafi
This is a brief report of the 19th Annual Meeting of the American Society of Gene and Cell Therapy that took place from May 4th through May 7th, 2016 in Washington, DC, USA. While the meeting provided many symposiums, lectures, and scientific sessions this report mainly focuses on one of the sessions on the "Gene Therapy for central nervous system (CNS) Diseases" and specifically on the "Gene Therapy for the globoid cell leukodystrophy or Krabbe disease. Two presentations focused on this subject utilizing two animal models of this disease: mice and dog models...
2016: BioImpacts: BI
Jaleh Barar, Ayuob Aghanejad, Marziyeh Fathi, Yadollah Omidi
INTRODUCTION: Ocular targeted therapy has enormously been advanced by implementation of new methods of drug delivery and targeting using implantable drug delivery systems (DDSs) or devices (DDDs), stimuli-responsive advanced biomaterials, multimodal nanomedicines, cell therapy modalities and medical bioMEMs. These technologies tackle several ocular diseases such as inflammation-based diseases (e.g., scleritis, keratitis, uveitis, iritis, conjunctivitis, chorioretinitis, choroiditis, retinitis, retinochoroiditis), ocular hypertension and neuropathy, age-related macular degeneration and mucopolysaccharidosis (MPS) due to accumulation of glycosaminoglycans (GAGs)...
2016: BioImpacts: BI
Alireza Sharifi, Mohammad Charjouei Moghadam
INTRODUCTION: Buerger's disease is an occlusive arterial disease that occurs mainly in medium and small vessels. This disease is associated with Tobacco usage. The existence of corkscrew collateral is one of the established characteristics of the Buerger's disease. METHODS: In this study, the computational fluid dynamics (CFD) simulation of blood flow within the corkscrew artery of the Buerger's disease is conducted. The geometry of the artery is constructed based on the actual corkscrew artery of a patient diagnosed with the Buerger's disease...
2016: BioImpacts: BI
Himan Heidari, Mohammad Kamalinejad, Maryam Noubarani, Mokhtar Rahmati, Iman Jafarian, Hasan Adiban, Mohammad Reza Eskandari
INTRODUCTION: Oxidative stress and carbonyl stress have essential mediatory roles in the development of diabetes and its related complications through increasing free radicals production and impairing antioxidant defense systems. Different chemical and natural compounds have been suggested for decreasing such disorders associated with diabetes. The objectives of the present study were to investigate the protective effects of Cucumis sativus (C. sativus) fruit (cucumber) in oxidative and carbonyl stress models...
2016: BioImpacts: BI
Sepideh Zununi Vahed, Abolfazl Barzegari, Yalda Rahbar Saadat, Somayeh Mohammadi, Nasser Samadi
INTRODUCTION: microRNAs (miRNAs) are considered to be novel molecular biomakers that could be exploited in the diagnosis and treatment of different diseases. The present study aimed to develop an efficient miRNA isolation method from different clinical specimens. METHODS: Total RNAs were isolated by Trizol reagent followed by precipitation of the large RNAs with potassium acetate (KCH3COOH), polyethylene glycol (PEG) 4000 and 6000, and lithium chloride (LiCl). Then, small RNAs were enriched and recovered from the supernatants by applying a combination of LiCl and ethanol...
2016: BioImpacts: BI
Francesco Angelini, Vittoria Ionta, Fabrizio Rossi, Fabio Miraldi, Elisa Messina, Alessandro Giacomello
INTRODUCTION: Cardiac progenitor cells (CPCs) represent a powerful tool in cardiac regenerative medicine. Pre-clinical studies suggest that most of the beneficial effects promoted by the injected cells are due to their paracrine activity exerted on endogenous cells and tissue. Exosomes are candidate mediators of this paracrine effects. According to their potential, many researchers have focused on characterizing exosomes derived from specific cell types, but, up until now, only few studies have analyzed the possible in vitro effects of bovine serum-derived exosomes on cell proliferation or differentiation...
2016: BioImpacts: BI
Saeed Azandeh, Anneh Mohammad Gharravi, Mahmoud Orazizadeh, Ali Khodadi, Mahmoud Hashemi Tabar
INTRODUCTION: The goal of the study described here, was to investigate the potential of umbilical cord derived mesenchymal stem cell (UC-MSCs) into hepatocyte like cells in a sequential 2D and 3D differentiation protocols as alternative therapy. METHODS: Mesenchymal stem cells (MSCs) were isolated from the umbilical cord (UC) and CD markers were analyzed by flow cytometry. For hepatic differentiation of UC-MSCs, cells were induced with a sequential 4-step protocol in 3D and 2D culture system...
2016: BioImpacts: BI
Reza Heidari, Maryam Rasti, Babak Shirazi Yeganeh, Hossein Niknahad, Arastoo Saeedi, Asma Najibi
INTRODUCTION: Sulfasalazine is a drug commonly administrated against inflammatory-based disorders. On the other hand, kidney and liver injury are serious adverse events accompanied by sulfasalazine administration. No specific therapeutic option is available against this complication. The current investigation was designed to evaluate the potential protective effects of taurine against sulfasalazine-induced kidney and liver injury in rats. METHODS: Male Sprague-Dawley rats were administered with sulfasalazine (600 mg/kg, oral) for 14 consecutive days...
2016: BioImpacts: BI
Azin Jahangiri, Khosro Adibkia
During recent years, nanoscaled materials have gained much attention because of their applications in the field of pharmaceutical and biomedical sciences. Electrospinning/electrospraying, as simple, effective and single-step methods, are used in the preparation of nanostructured materials (nanofibers and nanobeads). They offer an opportunity for direct encapsulation of the different types of drug molecules. The generated nanomaterials possess high surface area with porous characteristics, and the liberation of the loaded drugs follows a controlled-release pattern...
2016: BioImpacts: BI
Sonu Gandhi, Pankaj Suman, Ashok Kumar, Prince Sharma, Neena Capalash, C Raman Suri
INTRODUCTION: Immunosensor for illicit drugs have gained immense interest and have found several applications for drug abuse monitoring. This technology has offered a low cost detection of narcotics; thereby, providing a confirmatory platform to compliment the existing analytical methods. METHODS: In this minireview, we define the basic concept of transducer for immunosensor development that utilizes antibodies and low molecular mass hapten (opiate) molecules. RESULTS: This article emphasizes on recent advances in immunoanalytical techniques for monitoring of opiate drugs...
2015: BioImpacts: BI
Mohammad-Hossein Biglu, Shukuh Riazi
INTRODUCTION: We may define the nanomedicine as the use of nanotechnology in the health care, disease diagnoses and treatment in order to maintain and increase the health status of a population through improve pharmacotherapy. The main objective of the current study is to analyze and visualize the co-authorship network of all papers in the field of nanomedicine published throughout 2002-2014 in journals and indexed in the Web of Science database. METHODS: The Web of Science database was used to extract all papers indexed as a topic of nanomedicine through 2002-2014...
2015: BioImpacts: BI
Sanaz Sajedi-Amin, Karim Assadpour-Zeynali, Vahid Panahi-Azar, Abbas Kebriaeezadeh, Maryam Khoubnasabjafari, Khalil Ansarin, Vahid Jouyban-Gharamaleki, Abolghasem Jouyban
INTRODUCTION: Microextraction processes with UV-Vis measurement have been developed and validated for analysis of bosentan in biological samples. METHODS: In this work, liquid-liquid microextraction procedures (DLLME & USAEME) were employed for cleanup, pre-concentration, and determination of bosentan in biological samples by UV-Vis spectroscopy at 270 nm. The method was validated and applied to the determination of bosentan in spiked serum, exhaled breath condensate and urine samples...
2015: BioImpacts: BI
Seyed Hossein Rasta, Shima Nikfarjam, Alireza Javadzadeh
INTRODUCTION: Retinal capillary nonperfusion (CNP) is one of the retinal vascular diseases in diabetic retinopathy (DR) patients. As there is no comprehensive detection technique to recognize CNP areas, we proposed a different method for computing detection of ischemic retina, non-perfused (NP) regions, in fundus fluorescein angiogram (FFA) images. METHODS: Whilst major vessels appear as ridges, non-perfused areas are usually observed as ponds that are surrounded by healthy capillaries in FFA images...
2015: BioImpacts: BI
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