Fatemeh Ganji, Marzieh Ebrahimi, Ali Shirani, Mahtab Golmohammadi, Mazaher Gholipourmalekabadi, Maryam Kashanian, Kiana Koolaeinezhad, Hamid Reza Davari, Seyed Ali Javad Mousavi, Hamid Reza Aghayan, Babak Arjmand, Ramin Heshmat, Nushin Karkuki Osguei, Ali Samadikuchaksaraei
INTRODUCTION: For cell-based therapies of lung injury, several cell sources have been extensively studied. However, the potential of human fetal respiratory cells has not been systematically explored for this purpose. Here, we hypothesize that these cells could be one of the top sources and hence, we extensively updated the definition of their phenotype. METHODS: Human fetal lower respiratory tissues from pseudoglandular and canalicular stages and their isolated epithelial cells were evaluated by immunostaining, electron microscopy, flow cytometry, organoid assay, and gene expression studies...
2023: BioImpacts: BI