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BioImpacts: BI

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https://www.readbyqxmd.com/read/28752076/molecular-machineries-of-ph-dysregulation-in-tumor-microenvironment-potential-targets-for-cancer-therapy
#1
REVIEW
Mohammad Reza Asgharzadeh, Jaleh Barar, Mohammad M Pourseif, Morteza Eskandani, Mojtaba Jafari Niya, Mohammad Reza Mashayekhi, Yadollah Omidi
Introduction: Cancer is an intricate disorder/dysfunction of cells that can be defined as a genetic heterogeneity in human disease. Therefore, it is characterized by several adaptive complex hallmarks. Among them, the pH dysregulation appears as a symbol of aberrant functions within the tumor microenvironment (TME). In comparison with normal tissues, in the solid tumors, we face with an irregular acidification and alkalinization of the extracellular and intracellular fluids. Methods: In this study, we comprehensively discussed the most recent reports on the hallmarks of solid tumors to provide deep insights upon the molecular machineries involved in the pH dysregulation of solid tumors and their impacts on the initiation and progression of cancer...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28752075/mir-155-effectively-induces-apoptosis-in-k562-philadelphia-positive-cell-line-through-upregulation-of-p27kip1
#2
Mahdi Edalati Fathabad, Morteza Karimipoor, Shaban Alizadeh, Asghar Abdoli, Amir Atashi, Mahtab Sayadi
Introduction: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by the Philadelphia chromosome translocation, at (9; 22), which results in BCR-ABL fusion tyrosine kinase oncoprotein. This fusion induces down-regulation of miR-155. Upregulation of miR-155 can influence cell fate via the effect on p27kip1 and apoptosis. The aim of this study was to induce apoptosis in K562 CML cell line by overexpression of miR-155. Methods: The K562 cell line was transfected with pLenti-III-pre mir155-GFP constructs through electroporation...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28752074/co-liquefaction-with-acetone-and-gc-analysis-of-volatile-compounds-in-exhaled-breath-as-lung-cancer-biomarkers
#3
Abolghasem Jouyban, Djavanshir Djozan, Parastou Mohammadandashti, Aliakbar Alizadeh-Nabil, Hooshangh Ghorbanpour, Maryam Khoubnasabjafari, Mohammad Mohammadzadeh
Introduction: A simple, rapid and low cost method for enrichment of volatile organic compounds (VOCs) from exhaled breath (EB) is presented. Methods: A 1000 mL home-made extraction device was filled with EB. The VOCs were extracted and condensed in 0.5 mL acetone. Recognition of volatiles in the real studied EB samples was performed by a GC-MS. Results: The method displays an extraction efficiency of >86% with the enrichment factor of 1929 for octanal. Limits of detection and quantification, and linear dynamic range were 0...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28752073/surface-plasmon-resonance-and-molecular-docking-studies-of-bovine-serum-albumin-interaction-with-neomycin-kinetic-and-thermodynamic-analysis
#4
Maryam Sharifi, Jafar Ezzati Nazhad Dolatabadi, Farzaneh Fathi, Mostafa Zakariazadeh, Abolfazl Barzegar, Mohammad Rashidi, Habib Tajalli, Mohammad-Reza Rashidi
Introduction: The interactions between biomacromolecules such as serum albumin (SA) and various drugs have attracted increasing research attention in recent years. However, the study of SA with those drugs that have relatively high hydrophilicity and a lower affinity for SA could be a challenging issue. At the present study, the interaction of bovine SA (BSA) with neomycin as a hydrophilic drug has been investigated using surface plasmon resonance (SPR) and molecular docking methods. Methods: BSA was immobilized on the carboxymethyl dextran hydrogel sensor chip after activation of carboxylic groups through NHS/EDC and, then, the neomycin interaction with BSA at different concentrations (1-128 ┬ÁM) was investigated...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28752072/early-endocrine-disruptors-exposure-acts-on-3t3-l1-differentiation-and-endocrine-activity
#5
Sofiane Boudalia, Christine Belloir, Marie-Louise Miller, Marie-Chantal Canivenc-Lavier
Introduction: Data from last years suggested that early exposure to endocrine disruptors (EDs) can predispose newborns to endocrine dysfunction of adipocytes, obesity, and associated disorders. The implication of EDs at low doses on adipocyte development has been poorly investigated. For instance, vinclozolin (V) is a dicarboximide fungicide widely used in agriculture since the 90's, alone or in mixture with genistein (G), an isoflavonoid from Leguminosae. This study aims to identify the effect of vinclozolin alone or with genistein, on adipose tissue properties using cell culture...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28752071/an-in-vitro-ethnopharmacological-study-on-prangos-ferulacea-a-wound-healing-agent
#6
Keyvan Yousefi, Sanaz Hamedeyazdan, Darya Hodaei, Farzaneh Lotfipour, Behzad Baradaran, Mona Orangi, Fatemeh Fathiazad
Introduction: Traditionally Prangos ferulacea root is being used as an effective wound healing agent especially for pus-filled wounds both in human and stocks in the western north of Iran. Regarding the subject we decided to study P. ferulacea roots essential oil (PFE) for its antimicrobial and wound healing activities. Methods: The in vitro wound healing activity of PFE was evaluated in the mouse fibroblast cell line L929 using MTT assay of cell viability and cytotoxicity indices. Scratch assay as an in vitro model of wound healing assay was also conducted in this study...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28752070/polymers-in-our-daily-life
#7
EDITORIAL
Hassan Namazi
Polymers are widely used advanced materials, which are found almost in every material used in our daily life. To date, the importance of polymers has been much more highlighted because of their applications in different dominions of sciences, technologies and industry - from basic uses to biopolymers and therapeutic polymers. The main aim of this editorial is to accentuate the pragmatic impacts of polymers in human daily life.
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546954/pleiotropic-cytotoxicity-of-vaca-toxin-in-host-cells-and-its-impact-on-immunotherapy
#8
REVIEW
Farnaz Fahimi, Mohammad Reza Tohidkia, Mehdi Fouladi, Reza Aghabeygi, Naser Samadi, Yadollah Omidi
Introduction: In the recent decades, a number of studies have highlighted the importance of Helicobacter pylori in the initiation and development of peptic ulcer and gastric cancer. Some potential virulence factors (e.g., urease, CagA, VacA, BabA) are exploited by this microorganism, facilitating its persistence through evading human defense mechanisms. Among these toxins and enzymes, vacuolating toxin A (VacA) is of a great importance in the pathogenesis of H. pylori. VacA toxin shows different pattern of cytotoxicity through binding to different cell surface receptors in various cells...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546953/perspective-highlights-on-biodegradable-polymeric-nanosystems-for-targeted-therapy-of-solid-tumors
#9
REVIEW
Marziyeh Fathi, Jaleh Barar
Introduction: Polymeric nanoparticles (NPs) formulated using biodegradable polymers offer great potential for development of de novo drug delivery systems (DDSs) capable of delivering a wide range of bioactive agents. They can be engineered as advanced multifunctional nanosystems (NSs) for simultaneous imaging and therapy known as theranostics or diapeutics. Methods: A brief prospective is provided on biomedical importance and applications of biodegradable polymeric NSs through reviewing the recently published literature...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546952/time-dependency-of-morphological-remodeling-of-endothelial-cells-in-response-to-substrate-stiffness
#10
Zahra Goli-Malekabadi, Mohammad Tafazzoli-Shadpour, Ali Tamayol, Ehsan Seyedjafari
Introduction: Substrate stiffness regulates cellular behavior as cells experience different stiffness values of tissues in the body. For example, endothelial cells (ECs) covering the inner layer of blood vessels are exposed to different stiffness values due to various pathologic and physiologic conditions. Despite numerous studies, cells by time span sense mechanical properties of the substrate, but the response is not well understood. We hypothesized that time is a major determinant influencing the behavior of cells seeded on substrates of varying stiffness...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546951/common-chemotherapeutic-agents-modulate-fatty-acid-distribution-in-human-hepatocellular-carcinoma-and-colorectal-cancer-cells
#11
Amir Mehdizadeh, Morteza Bonyadi, Masoud Darabi, Reza Rahbarghazi, Soheila Montazersaheb, Kobra Velaei, Maghsood Shaaker, Mohammad-Hossein Somi
Introduction: Cancer cells are critically correlated with lipid molecules, particularly fatty acids, as structural blocks for membrane building, energy sources, and related signaling molecules. Therefore, cancer progression is in direct correlation with fatty acid metabolism. The aim of this study was to investigate the potential effects of common chemotherapeutic agents on the lipid metabolism of hepatocellular carcinoma (HCC) and colorectal cancer (CRC) cells, with a focus on alterations in cellular fatty acid contents...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546950/genetic-polymorphisms-of-multidrug-and-toxin-extrusion-proteins-mate1-and-mate2-in-south-indian-population
#12
Gerard Marshall Raj, Jayanthi Mathaiyan, Mukta Wyawahare, Katiboina Srinivasa Rao, Rekha Priyadarshini
Introduction: Drug transporters are key determinants of pharmacokinetic and pharmacodynamic profiles of certain drugs. SLC47A1 (MATE1) and SLC47A2 (MATE2) are major efflux transporters involved in the hepatic and renal excretion of many cationic drugs including metformin. Our study was proposed to determine the normative frequencies of the single nucleotide polymorphisms (SNPs) rs2289669 and rs12943590 in the SLC47A1 and SLC47A2 genes, respectively, in South Indian population and also to compare those with those of the HapMap populations...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546949/properties-of-macerated-herbal-oil
#13
Fahsai Kantawong, Supawatchara Singhatong, Aomjai Srilamay, Kantarose Boonyuen, Niroot Mooti, Phenphichar Wanachantararak, Thasaneeya Kuboki
Introduction: The addition of herbs into hot sesame oil could increase the oil-pulling efficiency of sesame oil. The aim of present study was to modify the proportion of herbs and sesame oil with the addition of other ingredients including menthol, camphor, and borneol and improve the medicinal properties and the scent of the oil. Methods: Macerated herbal oil was prepared by heat extraction of five species of herbs (Zingiber cassumunar, Zingiber zerumbet, Plantago major Linn, Citrus hystrix, and Amomum biflorum) with hot sesame oil...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546948/liquigroud-technique-a-new-concept-for-enhancing-dissolution-rate-of-glibenclamide-by-combination-of-liquisolid-and-co-grinding-technologies
#14
Leila Azharshekoufeh, Javad Shokri, Mohammad Barzegar-Jalali, Yousef Javadzadeh
Introduction: The potential of combining liquisolid and co-grinding technologies (liquiground technique) was investigated to improve the dissolution rate of a water-insoluble agent (glibenclamide) with formulation-dependent bioavailability. Methods: To this end, different formulations of liquisolid tablets with a wide variety of non-volatile solvents contained varied ratios of drug: solvent and dissimilar carriers were prepared, and then their release profiles were evaluated. Furthermore, the effect of size reduction by ball milling on the dissolution behavior of glibenclamide from liquisolid tablets was investigated...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546947/carotenoids-from-microalgae-to-block-oxidative-stress
#15
EDITORIAL
Marisol Zuluaga, Virginie Gueguen, Graciela Pavon-Djavid, Didier Letourneur
Reactive oxygen species (ROS) are produced under normal physiological conditions and involved in several cellular biochemical processes. Their external or endogenous overproduction induces a disruption of redox signaling and control known as oxidative stress. Under oxidative stress, the cell membrane structures, enzyme functions and gene expression are compromised leading to the pathogenesis of several chronic inflammatory diseases including the cardiovascular pathologies. Attempts to find new therapeutic molecules capable of blocking the oxidative stress are of crucial importance...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28265540/retraction-note-the-effects-of-valsartan-on-renal-glutathione-peroxidase-expression-in-alleviation-of-cyclosporine-nephrotoxicity-in-rats
#16
Sina Raeisi, Amir Ghorbanihaghjo, Hassan Argani, Siavoush Dastmalchi, Babollah Ghasemi, Teimour Ghazizadeh, Nadereh Rashtchizadeh, Mehran Mesgari Abbasi, Nasrin Bargahi, Mahboob Nemati, Ali Mota, Amir Mansour Vatankhah
[This retracts the article DOI: 10.15171/bi.2016.18.].
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/28265539/blood-brain-barrier-transport-machineries-and-targeted-therapy-of-brain-diseases
#17
REVIEW
Jaleh Barar, Mohammad A Rafi, Mohammad M Pourseif, Yadollah Omidi
Introduction: Desired clinical outcome of pharmacotherapy of brain diseases largely depends upon the safe drug delivery into the brain parenchyma. However, due to the robust blockade function of the blood-brain barrier (BBB), drug transport into the brain is selectively controlled by the BBB formed by brain capillary endothelial cells and supported by astrocytes and pericytes. Methods: In the current study, we have reviewed the most recent literature on the subject to provide an insight upon the role and impacts of BBB on brain drug delivery and targeting...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/28265538/lactobacillus-species-mediated-synthesis-of-silver-nanoparticles-and-their-antibacterial-activity-against-opportunistic-pathogens-in-vitro
#18
Inna Garmasheva, Nadezhda Kovalenko, Sergey Voychuk, Andriy Ostapchuk, Olena Livins'ka, Ljubov Oleschenko
Introduction: Application of lactic acid bacteria for synthesis of silver (AG) nanoparticles (NPs) could be a good ecological friendly alternative to chemical and physical methods. The objective of this study was to investigate the biosynthesis of silver NPs using Lactobacillus strains and to compare their monosaccharide composition of capsular exopolysaccharides and the antibacterial activity of synthesized nanoparticles. Methods: The washed cells of 22 Lactobacillus strains were used for in vitro silver nanoparticle biosynthesis from silver nitrate solution...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/28265537/breast-cancer-publication-network-profile-of-co-authorship-and-co-organization
#19
Mohammad-Hossein Biglu, Parvaneh Abotalebi, Mostafa Ghavami
Introduction: Breast cancer is one of the highest reasons of deaths for people in the world. The objective of current study is to analyze and visualize the trend of global scientific activities in the field of breast cancer during a period of 10 years through 2006-2015. Methods: The current study was performed by utilizing the scientometrics analysis and mapping the co-authorship and co-organization networks. The Web of Science Core Collection (WoS-CC)database was used to extract all papers indexed as a topic of breast cancer through 2006 to 2015...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/28265536/role-of-lactobacillus-plantarum-mtcc1325-in-membrane-bound-transport-atpases-system-in-alzheimer-s-disease-induced-rat-brain
#20
Nimgampalle Mallikarjuna, Kukkarasapalli Praveen, Kuna Yellamma
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder, clinically characterized by memory dysfunction and progressive loss of cognition. No curative therapeutic or drug is available for the complete cure of this disease. The present study was aimed to evaluate the efficacy of Lactobacillus plantarum MTCC1325 in ATPases activity in the selected brain regions of rats induced with Alzheimer's. Methods: For the study, 48 healthy Wistar rats were divided into four groups: group I as control group, group II as AD model (AD induced by intraperitoneal injection of D-Galactose, 120 mg/kg body weight for 6 weeks), group III as normal control rats which were orally administered only with L...
2016: BioImpacts: BI
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