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Journal of Stem Cells & Regenerative Medicine

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https://www.readbyqxmd.com/read/29391753/randomized-controlled-trial-comparing-hyaluronic-acid-platelet-rich-plasma-and-the-combination-of-both-in-the-treatment-of-mild-and-moderate-osteoarthritis-of-the-knee-letter-to-the-editor-author-response
#1
Sandeep Patel, M S Dhillon, Tungish Bansal
No abstract text is available yet for this article.
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/29391752/stemregenin-1-selectively-promotes-expansion-of-multipotent-hematopoietic-progenitors-derived-from-human-embryonic-stem-cells
#2
Lihong Tao, Padma Priya Togarrati, Kyung-Dal Choi, Kran Suknuntha
Human embryonic stem cell (hESC)-derived hematopoietic stem/progenitor cells hold tremendous potential as alternative cell sources for the treatment of various hematological diseases, drug discovery and toxicological screening. However, limited number of hematopoietic stem/progenitor cells generated from the differentiation of hESCs hinders their downstream applications. Here, we show that aryl hydrocarbon receptor antagonist StemRegenin 1 (SR1) selectively promotes expansion of hESC-derived lin- CD34+ hematopoietic progenitors in a concentration-dependent manner...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/29391751/increased-motility-of-mesenchymal-stem-cells-is-correlated-with-inhibition-of-stimulated-peripheral-blood-mononuclear-cells-in-vitro
#3
Alessandro Bertolo, David Pavlicek, Armin Gemperli, Martin Baur, Tobias Pötzel, Jivko Stoyanov
Immunomodulatory properties of mesenchymal stem cells (MSC) are key components of their successful applications in clinical setting. However, treatments based on MSC immunomodulation need understanding of cell characteristics before cell transplantation. We used live-imaging to test the suitability of the MSC motility as a parameter for quick prediction of the immunomodulatory potential of human MSC in regulating the activity of stimulated peripheral blood mononuclear cells (PBMC) in vitro . Bone marrow MSC, from various donors and in vitro passages, were cultured with or without stimulated PBMC...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/29391750/neural-stem-progenitor-cells-maintained-in-vitro-under-different-culture-conditions-alter-differentiation-capacity-of-monocytes-to-generate-dendritic-cells
#4
Alexey Yu Lupatov, Rimma A Poltavtseva, Oxana A Bystrykh, Konstantin N Yarygin, Gennady T Sukhikh
Cell therapy of the nervous system disorders using neural stem/progenitor cells (NSPCs) proved its efficacy in preclinical and pilot clinical studies. The mechanisms of the beneficial effects of NSPCs transplantation include replacement of damaged cells, paracrine activation of the regeneration, and immunomodulation. Detailed assessment of NSPCs-induced immunomodulation can contribute to better control of autoimmune reactions and inflammation in patients with neurodegenerative diseases. Interactions of NSPCs with dendritic cells (DCs), the key players in the induction of the immune system response to antigens are of particular interest...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/29391749/cathepsin-k-localizes-to-equine-bone-in-vivo-and-inhibits-bone-marrow-stem-and-progenitor-cells-differentiation-in-vitro
#5
Hayam Hussein, Prosper Boyaka, Jennifer Dulin, Duncan Russell, Lauren Smanik, Mohamed Azab, Alicia L Bertone
Selective inhibition of Cathepsin K (CatK) has a promising therapeutic potential for diseases associated with bone loss and osseous inflammation, such as osteoarthritis, periodontitis, and osteoporosis. In horses, stress-related bone injuries are common and accompanied by bone pain and inflammation resulting in excessive bone resorption and periostitis. VEL-0230 is a highly selective inhibitor of CatK that significantly decreased bone resorption and increased bone formation biomarkers. The goal of this study was to demonstrate the presence of CatK in equine bone and a simultaneous influence on the bone marrow cellular components including function and differentiation...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/29391748/comparing-the-in-vivo-and-in-vitro-effects-of-hypoxia-3-o-2-on-directly-derived-cells-from-murine-cardiac-explants-versus-murine-cardiosphere-derived-cells
#6
Muhammad Mehdi Amirrasouli, Mehdi Shamsara
Coronary heart disease (CHD) is still one of the main causes of death in the world, despite significant advances in clinical treatments. Stem cell transplantation methods have the potential to improve cardiac function and patients' outcome following heart attack, but optimal cell types, cell preparation methods and cell delivery routes are yet to be developed. Mammalian hearts contain a small fraction of progenitor cells which, in culture, migrate out of the cardiac explants, known as explant-derived cell (EDCs) and contribute to spheroids known as cardiospheres (Csphs)...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/29391747/biomimicry-in-mending-the-broken-heart-will-hypoxia-and-pulsatile-flow-play-cupids
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684895/comparative-study-of-the-methods-of-extracting-mesenchymal-stem-cells-from-cryopreserved-wharton-s-jelly
#8
Peng Yew Kenny Boey, Say Liang Daniel Lim, Kin Fai Tang, Ming Ming Li, Andrew Krishna Ekaputra, Prosanto Kumar Chowdhury, Rajat Anand Gopal Mukherjee, Jennifer Teo, Arvin C Faundo, Yoke Fong Chiew
The Wharton's Jelly (WJ) is an established source of mesenchymal stem cells (MSC). We compared 3 methods of extracting WJ-MSC from cryopreserved tissue and determined that enzymatic digestion of the WJ yielded the most viable MSC, compared to the explant and mechanical digestion methods. The enzymatically-released WJ-MSC conformed to the International Society for Cellular Therapy (ISCT) criteria: displayed plastic-adherence, co-expressed CD73, CD90, CD105 and were negative for hematopoietic lineage cell markers...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684894/mouse-ipsc-generated-with-porcine-reprogramming-factors-as-a-model-for-studying-the-effects-of-non-silenced-heterologous-transgenes-on-pluripotency
#9
Stoyan G Petkov, Silke Glage, Heiner Niemann
Mouse somatic cells can be reprogrammed to pluripotency by the ectopic expression of four pluripotency transcription factors, Oct4, Sox2, cmyc, and Klf4. Usually, silencing of the exogenous reprogramming factors is considered to be essential for complete reprogramming and differentiation. In the vast majority of studies, murine pluripotency transcription factor sequences have been used for the reprogramming of mouse fibroblasts to induced pluripotent stem cells (iPSC). The effectiveness of xenogeneic transcription factors in miPSC generation has not yet been investigated in detail...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684893/safety-and-feasibility-of-autologous-mesenchymal-stem-cell-transplantation-in-chronic-stroke-in-indian-patients-a-four-year-follow-up
#10
Ashu Bhasin, Senthil S Kumaran, Rohit Bhatia, Sujata Mohanty, M V Padma Srivastava
Introduction: Stem cell (SC) therapy has been envisioned as a therapeutic vehicle to promote recovery in resistant neurological diseases. Knowing the logistics and paradigms in recovery processes after Stroke, clinicians have pioneered the transplantation therapy. This study presents four-year follow up of our previous trial transplanting bone-marrow-derived animal-free culture expanded intravenous mesenchymal stem cells (MSCs) in chronic stroke which was published in 2010. Methods: We performed an open-label, pilot trial on 12 patients with chronic stroke...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684892/the-adaptability-of-somatic-stem-cells-a-review
#11
REVIEW
Kenyon S Tweedell
Cell and tissue specific somatic stem cells develop as dynamic populations of precursor cells to discrete tissue and organ differentiation during embryonic and fetal stages and their potential evolves with development. Some of their progeny are sequestered into separate cell niches of tissues as adult somatic stem cells at various times during organ development and differentiation These are diverse cell populations of stem and progenitor cells that respond to homeostatic needs for cell and tissue maintenance and the cycling of differentiated cells for physiological/ endocrinological changes...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684891/-cells-as-tools-to-cell-s-produced-tools-an-evolving-paradigm-in-regenerative-medicine
#12
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096635/metaniche-session-2016-tailor-made-sensors-for-rapid-therapeutic-drug-monitoring-interactions-between-biomaterial-physicists-chemical-engineers-and-clinicians-for-successful-translation-of-technologies-in-healthcare
#13
Yasuo Yoshimi, Subramanian Pushkala, Harikrishnan Vijaykumar, Vidyasagar Devaprasad Dedeepiya, Arockyaa Ignacy, Jose Swaminathan, Mathaiyan Rajmohan, Ramalingam Karthick, Samuel Jk Abraham
No abstract text is available yet for this article.
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096634/intraventricular-transplantation-of-autologous-bone-marrow-mesenchymal-stem-cells-via-ommaya-reservoir-in-persistent-vegetative-state-patients-after-haemorrhagic-stroke-report-of-two-cases-review-of-the-literature
#14
Asra Al Fauzi, Nur Setiawan Suroto, Abdul Hafid Bajamal, Moh Hasan Machfoed
Background: One of the most devastating diseases, stroke, is a leading cause of death and disability worldwide with severe emotional and economic consequences. The purpose of this article is mainly to report the effect of intraventricular transplantation via an Ommaya reservoir using autologous bone marrow mesenchymal stem cells (BM-MSCs) in haemorrhagic stroke patients. Case Presentations: Two patients, aged 51 and 52, bearing sequels of haemorrhagic stroke were managed by intraventricular transplantation of BM-MSCs obtained from their own bone marrow...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096633/mesenchymal-stem-cells-seeded-bio-ceramic-construct-for-bone-regeneration-in-large-critical-size-bone-defect-in-rabbit
#15
Swapan Kumar Maiti, Ajantha Ravindran Ninu, Palakkara Sangeetha, Dayamon D Mathew, Paramasivam Tamilmahan, Deepika Kritaniya, Naveen Kumar, Jurgen Hescheler
Bone marrow derived mesenchymal stem cells (BMSC) represent an attractive cell population for tissue engineering purpose. The objective of this study was to determine whether the addition of recombinant human bone morphogenetic protein (rhBMP-2) and insulin-like growth factor (IGF-1) to a silica-coated calcium hydroxyapatite (HASi) - rabbit bone marrow derived mesenchymal stem cell (rBMSC) construct promoted bone healing in a large segmental bone defect beyond standard critical -size radial defects (15mm) in rabbits...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096632/compatibility-of-porous-chitosan-scaffold-with-the-attachment-and-proliferation-of-human-adipose-derived-stem-cells-in-vitro
#16
Sankaralakshmi Gomathysankar, Ahmad Sukari Halim, Nik Soriani Yaacob, Norhayati Mohd Noor, Mohaini Mohamed
Adipose-derived stem cells (ASCs) have potential applications in the repair and regeneration of various tissues and organs. The use of various scaffold materials as an excellent template for mimicking the extracellular matrix to induce the attachment and proliferation of different cell types has always been of interest in the field of tissue engineering because ideal biomaterials are in great demand. Chitosan, a marine polysaccharide, have wide clinical applications and it acts as a promising scaffold for cell migration and proliferation...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096631/randomized-controlled-trial-comparing-hyaluronic-acid-platelet-rich-plasma-and-the-combination-of-both-in-the-treatment-of-mild-and-moderate-osteoarthritis-of-the-knee
#17
José F S D Lana, Adam Weglein, Steve E Sampson, Eduardo F Vicente, Stephany Cares Huber, Clarissa V Souza, Mary A Ambach, Hunter Vincent, Aline Urban-Paffaro, Carolina M K Onodera, Joyce M Annichino-Bizzacchi, Maria Helena A Santana, William D Belangero
Objective: This study aims at evaluating the clinical effects of Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) as individual treatments for mild to moderate Osteoarthritis (OA) and it also examines the potential synergistic effects of PRP in combination with HA. Research continues to emerge examining the potential therapeutic efficacy of HA and PRP as autologous injectable treatments for joint arthritis. However, there is a paucity of research investigating the effects of combining HA and PRP on pain and functional status in patients with OA...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096630/new-trends-in-heart-regeneration-a-review
#18
REVIEW
Andrei Kochegarov, Larry F Lemanski
In this review, we focus on new approaches that could lead to the regeneration of heart muscle and the restoration of cardiac muscle function derived from newly-formed cardiomyocytes. Various strategies for the production of cardiomyocytes from embryonic stem cells, induced pluripotent stem cells, adult bone marrow stem cells and cardiac spheres from human heart biopsies are described. Pathological conditions which lead to atherosclerosis and coronary artery disease often are followed by myocardial infarction causing myocardial cell death...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096629/induced-pluripotent-stem-cells-as-a-cellular-model-for-studying-down-syndrome
#19
REVIEW
Anna Lisa Brigida, Dario Siniscalco
Down Syndrome (DS), or Trisomy 21 Syndrome, is one of the most common genetic diseases. It is a chromosomal abnormality caused by a duplication of chromosome 21. DS patients show the presence of a third copy (or a partial third copy) of chromosome 21 (trisomy), as result of meiotic errors. These patients suffer of many health problems, such as intellectual disability, congenital heart disease, duodenal stenosis, Alzheimer's disease, leukemia, immune system deficiencies, muscle hypotonia and motor disorders...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096628/eco-matters-in-out
#20
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Stem Cells & Regenerative Medicine
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