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Journal of Stem Cells & Regenerative Medicine

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https://www.readbyqxmd.com/read/28684895/comparative-study-of-the-methods-of-extracting-mesenchymal-stem-cells-from-cryopreserved-wharton-s-jelly
#1
Peng Yew Kenny Boey, Say Liang Daniel Lim, Kin Fai Tang, Ming Ming Li, Andrew Krishna Ekaputra, Prosanto Kumar Chowdhury, Rajat Anand Gopal Mukherjee, Jennifer Teo, Arvin C Faundo, Yoke Fong Chiew
The Wharton's Jelly (WJ) is an established source of mesenchymal stem cells (MSC). We compared 3 methods of extracting WJ-MSC from cryopreserved tissue and determined that enzymatic digestion of the WJ yielded the most viable MSC, compared to the explant and mechanical digestion methods. The enzymatically-released WJ-MSC conformed to the International Society for Cellular Therapy (ISCT) criteria: displayed plastic-adherence, co-expressed CD73, CD90, CD105 and were negative for hematopoietic lineage cell markers...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684894/mouse-ipsc-generated-with-porcine-reprogramming-factors-as-a-model-for-studying-the-effects-of-non-silenced-heterologous-transgenes-on-pluripotency
#2
Stoyan G Petkov, Silke Glage, Heiner Niemann
Mouse somatic cells can be reprogrammed to pluripotency by the ectopic expression of four pluripotency transcription factors, Oct4, Sox2, cmyc, and Klf4. Usually, silencing of the exogenous reprogramming factors is considered to be essential for complete reprogramming and differentiation. In the vast majority of studies, murine pluripotency transcription factor sequences have been used for the reprogramming of mouse fibroblasts to induced pluripotent stem cells (iPSC). The effectiveness of xenogeneic transcription factors in miPSC generation has not yet been investigated in detail...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684893/safety-and-feasibility-of-autologous-mesenchymal-stem-cell-transplantation-in-chronic-stroke-in-indian-patients-a-four-year-follow-up
#3
Ashu Bhasin, Senthil S Kumaran, Rohit Bhatia, Sujata Mohanty, M V Padma Srivastava
Introduction: Stem cell (SC) therapy has been envisioned as a therapeutic vehicle to promote recovery in resistant neurological diseases. Knowing the logistics and paradigms in recovery processes after Stroke, clinicians have pioneered the transplantation therapy. This study presents four-year follow up of our previous trial transplanting bone-marrow-derived animal-free culture expanded intravenous mesenchymal stem cells (MSCs) in chronic stroke which was published in 2010. Methods: We performed an open-label, pilot trial on 12 patients with chronic stroke...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684892/the-adaptability-of-somatic-stem-cells-a-review
#4
REVIEW
Kenyon S Tweedell
Cell and tissue specific somatic stem cells develop as dynamic populations of precursor cells to discrete tissue and organ differentiation during embryonic and fetal stages and their potential evolves with development. Some of their progeny are sequestered into separate cell niches of tissues as adult somatic stem cells at various times during organ development and differentiation These are diverse cell populations of stem and progenitor cells that respond to homeostatic needs for cell and tissue maintenance and the cycling of differentiated cells for physiological/ endocrinological changes...
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28684891/-cells-as-tools-to-cell-s-produced-tools-an-evolving-paradigm-in-regenerative-medicine
#5
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2017: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096635/metaniche-session-2016-tailor-made-sensors-for-rapid-therapeutic-drug-monitoring-interactions-between-biomaterial-physicists-chemical-engineers-and-clinicians-for-successful-translation-of-technologies-in-healthcare
#6
Yasuo Yoshimi, Subramanian Pushkala, Harikrishnan Vijaykumar, Vidyasagar Devaprasad Dedeepiya, Arockyaa Ignacy, Jose Swaminathan, Mathaiyan Rajmohan, Ramalingam Karthick, Samuel Jk Abraham
No abstract text is available yet for this article.
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096634/intraventricular-transplantation-of-autologous-bone-marrow-mesenchymal-stem-cells-via-ommaya-reservoir-in-persistent-vegetative-state-patients-after-haemorrhagic-stroke-report-of-two-cases-review-of-the-literature
#7
Asra Al Fauzi, Nur Setiawan Suroto, Abdul Hafid Bajamal, Moh Hasan Machfoed
Background: One of the most devastating diseases, stroke, is a leading cause of death and disability worldwide with severe emotional and economic consequences. The purpose of this article is mainly to report the effect of intraventricular transplantation via an Ommaya reservoir using autologous bone marrow mesenchymal stem cells (BM-MSCs) in haemorrhagic stroke patients. Case Presentations: Two patients, aged 51 and 52, bearing sequels of haemorrhagic stroke were managed by intraventricular transplantation of BM-MSCs obtained from their own bone marrow...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096633/mesenchymal-stem-cells-seeded-bio-ceramic-construct-for-bone-regeneration-in-large-critical-size-bone-defect-in-rabbit
#8
Swapan Kumar Maiti, Ajantha Ravindran Ninu, Palakkara Sangeetha, Dayamon D Mathew, Paramasivam Tamilmahan, Deepika Kritaniya, Naveen Kumar, Jurgen Hescheler
Bone marrow derived mesenchymal stem cells (BMSC) represent an attractive cell population for tissue engineering purpose. The objective of this study was to determine whether the addition of recombinant human bone morphogenetic protein (rhBMP-2) and insulin-like growth factor (IGF-1) to a silica-coated calcium hydroxyapatite (HASi) - rabbit bone marrow derived mesenchymal stem cell (rBMSC) construct promoted bone healing in a large segmental bone defect beyond standard critical -size radial defects (15mm) in rabbits...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096632/compatibility-of-porous-chitosan-scaffold-with-the-attachment-and-proliferation-of-human-adipose-derived-stem-cells-in-vitro
#9
Sankaralakshmi Gomathysankar, Ahmad Sukari Halim, Nik Soriani Yaacob, Norhayati Mohd Noor, Mohaini Mohamed
Adipose-derived stem cells (ASCs) have potential applications in the repair and regeneration of various tissues and organs. The use of various scaffold materials as an excellent template for mimicking the extracellular matrix to induce the attachment and proliferation of different cell types has always been of interest in the field of tissue engineering because ideal biomaterials are in great demand. Chitosan, a marine polysaccharide, have wide clinical applications and it acts as a promising scaffold for cell migration and proliferation...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096631/randomized-controlled-trial-comparing-hyaluronic-acid-platelet-rich-plasma-and-the-combination-of-both-in-the-treatment-of-mild-and-moderate-osteoarthritis-of-the-knee
#10
José F S D Lana, Adam Weglein, Steve E Sampson, Eduardo F Vicente, Stephany Cares Huber, Clarissa V Souza, Mary A Ambach, Hunter Vincent, Aline Urban-Paffaro, Carolina M K Onodera, Joyce M Annichino-Bizzacchi, Maria Helena A Santana, William D Belangero
Objective: This study aims at evaluating the clinical effects of Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) as individual treatments for mild to moderate Osteoarthritis (OA) and it also examines the potential synergistic effects of PRP in combination with HA. Research continues to emerge examining the potential therapeutic efficacy of HA and PRP as autologous injectable treatments for joint arthritis. However, there is a paucity of research investigating the effects of combining HA and PRP on pain and functional status in patients with OA...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096630/new-trends-in-heart-regeneration-a-review
#11
REVIEW
Andrei Kochegarov, Larry F Lemanski
In this review, we focus on new approaches that could lead to the regeneration of heart muscle and the restoration of cardiac muscle function derived from newly-formed cardiomyocytes. Various strategies for the production of cardiomyocytes from embryonic stem cells, induced pluripotent stem cells, adult bone marrow stem cells and cardiac spheres from human heart biopsies are described. Pathological conditions which lead to atherosclerosis and coronary artery disease often are followed by myocardial infarction causing myocardial cell death...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096629/induced-pluripotent-stem-cells-as-a-cellular-model-for-studying-down-syndrome
#12
REVIEW
Anna Lisa Brigida, Dario Siniscalco
Down Syndrome (DS), or Trisomy 21 Syndrome, is one of the most common genetic diseases. It is a chromosomal abnormality caused by a duplication of chromosome 21. DS patients show the presence of a third copy (or a partial third copy) of chromosome 21 (trisomy), as result of meiotic errors. These patients suffer of many health problems, such as intellectual disability, congenital heart disease, duodenal stenosis, Alzheimer's disease, leukemia, immune system deficiencies, muscle hypotonia and motor disorders...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/28096628/eco-matters-in-out
#13
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27398001/stem-cells-therapy-in-multiple-sclerosis-a-new-hope-for-progressive-forms
#14
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and represents a major cause of disability in young adults. Nowadays, the dichotomy between demyelination and neurodegeneration has been challenged, and both processes are believed to occur independently early in the disease process. 'Relapsing-remitting' MS is the most common subtype which generally shifts to a 'secondary progressive' form; MS progression is usually accompanied by a worsening of the motor, cognitive and emotional symptoms, as well as an increase in the disability level...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27398000/long-term-study-of-protective-mechanisms-of-human-adipose-derived-mesenchymal-stem-cells-on-cisplatin-induced-kidney-injury-in-sprague-dawley-rats
#15
Fatma M Elhusseini, Mohamed-Ahdy A A Saad, Nahla Anber, Doaa Elghannam, Mohamed-Ahmed Sobh, Aziza Alsayed, Sara El-Dusoky, Hussein Sheashaa, Hassan Abdel-Ghaffar, Mohamed Sobh
BACKGROUND/AIMS: Long-term evaluation of cisplatin induced nephrotoxicity and the probable renal protective activities of stem cells are lacking up until now. We evaluated the early and long-term role of human adipose derived mesenchymal stem cells (ADMSCs) in prevention or amelioration of cisplatin induced acute kidney injury (AKI) in Sprague-Dawley rats. For this, we determined the kidney tissue level of oxidative stress markers in conjugation with a renal histopathological scoring system of both acute and chronic renal changes...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397999/the-effect-of-pro-neurogenic-gene-expression-on-adult-subventricular-zone-precursor-cell-recruitment-and-fate-determination-after-excitotoxic-brain-injury
#16
Kathryn S Jones, Bronwen J Connor
Despite the presence of on-going neurogenesis in the adult mammalian brain, neurons are generally not replaced after injury. Using a rodent model of excitotoxic cell loss and retroviral (RV) lineage tracing, we previously demonstrated transient recruitment of precursor cells from the subventricular zone (SVZ) into the lesioned striatum. In the current study we determined that these cells included migratory neuroblasts and oligodendrocyte precursor cells (OPC), with the predominant response from glial cells...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397998/epigallocatechin-gallate-inhibits-mouse-mesenchymal-stem-cell-differentiation-to-adipogenic-lineage
#17
Baldeep Chani, Veena Puri, Ranbir Chander Sobti, Sanjeev Puri
Epigallocatechin gallate (EGCG) is a major component of green tea polyphenols having a potent anti-oxidant potential. Besides inhibiting the growth of many cancer cell types and inducing proliferation and differentiation in keratinocytes, it has been shown to promote reduction of body fat. The fact that mesenchymal stem cells (MSCs) have ability to self-renew and differentiate into the cells of mesodermal lineages, such as fat and bone, it is, thus, possible that EGCG may directly be involved in affecting fat metabolism through its effect on mesenchymal stem cells...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397997/oct4b-cd90-and-cd73-are-upregulated-in-bladder-tissue-following-electro-resection-of-the-bladder
#18
Takumi Takeuchi, Akiko Tonooka, Yumiko Okuno, Mami Hattori-Kato, Koji Mikami
AIM: We tested the hypothesis that stimulation by electro-resection of bladder tissue induces stem cells in the tissue repair process. MATERIALS & METHODS: After primary transurethral resection of a bladder tumor and surrounding tissue (TUR-Bt), second TUR-Bt was performed. Tissues excised by second TUR-Bt were immunohistochemically stained for Oct4, a marker of pluripotency, and for CD90 and CD73, markers of mesenchymal stromal cells, when no bladder tumor cells remained...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397996/in-vitro-study-of-the-role-of-thrombin-in-platelet-rich-plasma-prp-preparation-utility-for-gel-formation-and-impact-in-growth-factors-release
#19
Stephany Cares Huber, José Luiz Rosenberis Cunha Júnior, Silmara Montalvão, Letícia Queiroz da Silva, Aline Urban Paffaro, Francesca Aparecida Ramos da Silva, Bruno Lima Rodrigues, José Fabio Santos Duarte Lana, Joyce Maria Annichino-Bizzacchi
INTRODUCTION: The use of PRP has been studied for different fields, with promising results in regenerative medicine. Until now, there is no study in the literature evaluating thrombin levels in serum, used as autologous thrombin preparation. Therefore, in the present study we evaluated the role played by different thrombin concentrations in PRP and the impact in the release of growth factors. Also, different activators for PRP gel formation were evaluated. METHODS: Thrombin levels were measured in different autologous preparations: serum, L-PRP (PRP rich in leukocytes) and T-PRP (thrombin produced through PRP added calcium gluconate)...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397995/cues-for-cure-from-within
#20
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Stem Cells & Regenerative Medicine
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