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Journal of Stem Cells & Regenerative Medicine

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https://www.readbyqxmd.com/read/27398001/stem-cells-therapy-in-multiple-sclerosis-a-new-hope-for-progressive-forms
#1
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and represents a major cause of disability in young adults. Nowadays, the dichotomy between demyelination and neurodegeneration has been challenged, and both processes are believed to occur independently early in the disease process. 'Relapsing-remitting' MS is the most common subtype which generally shifts to a 'secondary progressive' form; MS progression is usually accompanied by a worsening of the motor, cognitive and emotional symptoms, as well as an increase in the disability level...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27398000/long-term-study-of-protective-mechanisms-of-human-adipose-derived-mesenchymal-stem-cells-on-cisplatin-induced-kidney-injury-in-sprague-dawley-rats
#2
Fatma M Elhusseini, Mohamed-Ahdy A A Saad, Nahla Anber, Doaa Elghannam, Mohamed-Ahmed Sobh, Aziza Alsayed, Sara El-Dusoky, Hussein Sheashaa, Hassan Abdel-Ghaffar, Mohamed Sobh
BACKGROUND/AIMS: Long-term evaluation of cisplatin induced nephrotoxicity and the probable renal protective activities of stem cells are lacking up until now. We evaluated the early and long-term role of human adipose derived mesenchymal stem cells (ADMSCs) in prevention or amelioration of cisplatin induced acute kidney injury (AKI) in Sprague-Dawley rats. For this, we determined the kidney tissue level of oxidative stress markers in conjugation with a renal histopathological scoring system of both acute and chronic renal changes...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397999/the-effect-of-pro-neurogenic-gene-expression-on-adult-subventricular-zone-precursor-cell-recruitment-and-fate-determination-after-excitotoxic-brain-injury
#3
Kathryn S Jones, Bronwen J Connor
Despite the presence of on-going neurogenesis in the adult mammalian brain, neurons are generally not replaced after injury. Using a rodent model of excitotoxic cell loss and retroviral (RV) lineage tracing, we previously demonstrated transient recruitment of precursor cells from the subventricular zone (SVZ) into the lesioned striatum. In the current study we determined that these cells included migratory neuroblasts and oligodendrocyte precursor cells (OPC), with the predominant response from glial cells...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397998/epigallocatechin-gallate-inhibits-mouse-mesenchymal-stem-cell-differentiation-to-adipogenic-lineage
#4
Baldeep Chani, Veena Puri, Ranbir Chander Sobti, Sanjeev Puri
Epigallocatechin gallate (EGCG) is a major component of green tea polyphenols having a potent anti-oxidant potential. Besides inhibiting the growth of many cancer cell types and inducing proliferation and differentiation in keratinocytes, it has been shown to promote reduction of body fat. The fact that mesenchymal stem cells (MSCs) have ability to self-renew and differentiate into the cells of mesodermal lineages, such as fat and bone, it is, thus, possible that EGCG may directly be involved in affecting fat metabolism through its effect on mesenchymal stem cells...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397997/oct4b-cd90-and-cd73-are-upregulated-in-bladder-tissue-following-electro-resection-of-the-bladder
#5
Takumi Takeuchi, Akiko Tonooka, Yumiko Okuno, Mami Hattori-Kato, Koji Mikami
AIM: We tested the hypothesis that stimulation by electro-resection of bladder tissue induces stem cells in the tissue repair process. MATERIALS & METHODS: After primary transurethral resection of a bladder tumor and surrounding tissue (TUR-Bt), second TUR-Bt was performed. Tissues excised by second TUR-Bt were immunohistochemically stained for Oct4, a marker of pluripotency, and for CD90 and CD73, markers of mesenchymal stromal cells, when no bladder tumor cells remained...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397996/in-vitro-study-of-the-role-of-thrombin-in-platelet-rich-plasma-prp-preparation-utility-for-gel-formation-and-impact-in-growth-factors-release
#6
Stephany Cares Huber, José Luiz Rosenberis Cunha Júnior, Silmara Montalvão, Letícia Queiroz da Silva, Aline Urban Paffaro, Francesca Aparecida Ramos da Silva, Bruno Lima Rodrigues, José Fabio Santos Duarte Lana, Joyce Maria Annichino-Bizzacchi
INTRODUCTION: The use of PRP has been studied for different fields, with promising results in regenerative medicine. Until now, there is no study in the literature evaluating thrombin levels in serum, used as autologous thrombin preparation. Therefore, in the present study we evaluated the role played by different thrombin concentrations in PRP and the impact in the release of growth factors. Also, different activators for PRP gel formation were evaluated. METHODS: Thrombin levels were measured in different autologous preparations: serum, L-PRP (PRP rich in leukocytes) and T-PRP (thrombin produced through PRP added calcium gluconate)...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27397995/cues-for-cure-from-within
#7
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27330256/an-invention-of-thermo-responsive-polymer-surface-yielding-cell-sheet-based-regenerative-therapies-in-cardiology-and-ophthalmology
#8
Yoshiki Sawa, Kottoorathu Mammen Cherian, Sujata Mohanty, Jegatheesan Saravana Ganesh, Samuel Jk Abraham
No abstract text is available yet for this article.
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27330255/expression-pattern-of-dkk-3-a-secreted-wnt-pathway-inhibitor-in-mouse-intestinal-tissue-and-three-dimensional-cultured-caco-2-spheroids
#9
Ken Kataoka, Yuji Rikitake, Yuki Ayabe
We investigated the expression pattern of Dkk-3, a secreted Wnt pathway inhibitor, in mouse intestinal tissue and three-dimensional cultured Caco-2 spheroids. Dkk-3 was expressed at the bottom of crypts from the mouse small intestine. Human colon adenocarcinoma Caco-2 cells expressed Dkk-3 under a semi-confluent condition, but Dkk-3 expression was seen in only some of the Caco-2 cells when the cells were sparse. Caco-2 cells formed hollow spheroids in Matrigel, and the layer-forming cells in the hollow spheroids expressed Dkk-3...
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27330254/protein-contaminations-impact-quantification-and-functional-analysis-of-extracellular-vesicle-preparations-from-mesenchymal-stromal-cells
#10
Meaghan Stolk, Martina Seifert
Extracellular vesicles (EV) awakened interest in the research on mesenchymal stromal cells by exploring their paracrine effects. However, many isolation protocols use bovine serum albumin (BSA) during the preparation of the EV. Therefore, we produced 'sham' BSA-EV and tested them in comparison to EV derived from mesenchymal stromal cells (MSC-EV). We found that BSA-EV did not express MSC-specific surface markers like CD29 and CD90. However, they were capable of reducing serum-starvation induced apoptosis in vitro in a kidney epithelial cell line to a similar extent as MSC-EV as measured by Annexin V/7-Aminoactinomycin D labeling and flow cytometry...
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27330253/route-of-delivery-influences-biodistribution-of-human-bone-marrow-derived-mesenchymal-stromal-cells-following-experimental-bone-marrow-transplantation
#11
Fangjing Wang, Saada Eid, James E Dennis, Kenneth R Cooke, Jeffery J Auletta, Zhenghong Lee
Mesenchymal stromal cells (MSCs) have shown promise as treatment for graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (alloBMT). Mechanisms mediating in vivo effects of MSCs remain largely unknown, including their biodistribution following infusion. To this end, human bone-marrow derived MSCs (hMSCs) were injected via carotid artery (IA) or tail vein (TV) into allogeneic and syngeneic BMT recipient mice. Following xenogeneic transplantation, MSC biodistribution was measured by bioluminescence imaging (BLI) using hMSCs transduced with a reporter gene system containing luciferase and by scintigraphic imaging using hMSCs labeled with [(99m)Tc]-HMPAO...
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27330252/extra-anatomic-transplantations-in-autologous-adult-cell-therapies-aiding-anatomical-regeneration-and-physiological-recovery-an-insight-and-categorization
#12
(no author information available yet)
No abstract text is available yet for this article.
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/26195892/the-effects-of-short-term-hypoxia-on-human-mesenchymal-stem-cell-proliferation-viability-and-p16-ink4a-mrna-expression-investigation-using-a-simple-hypoxic-culture-system-with-a-deoxidizing-agent
#13
Akira Ito, Tomoki Aoyama, Makoto Yoshizawa, Momoko Nagai, Junichi Tajino, Shoki Yamaguchi, Hirotaka Iijima, Xiangkai Zhang, Hiroshi Kuroki
A hypoxic environment is thought to be important for the maintenance of stemness and suppressing cell senescence, in stem cells. Therefore, a hypoxic condition is induced during cell expansion and/or induction of intended differentiation. However, the induction of these conditions requires a specially equipped hypoxia chamber and expensive gas mixtures, which are expensive and space-consuming. Owing to these restrictions, appropriate hypoxic conditions cannot be provided during cell transportation, which is increasingly required for regenerative medicine...
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/26195891/human-mesenchymal-stem-cells-stimulate-eahy926-endothelial-cell-migration-combined-proteomic-and-in-vitro-analysis-of-the-influence-of-donor-donor-variability
#14
Merlin N M Walter, Nupur Kohli, Neelam Khan, Triin Major, Heidi Fuller, Karina T Wright, Jan-Herman Kuiper, William E B Johnson
Mesenchymal stem cells (MSCs) stimulate angiogenesis within a wound environment and this effect is mediated through paracrine interactions with the endothelial cells present. Here we report that human MSC-conditioned medium (n=3 donors) significantly increased EaHy-926 endothelial cell adhesion and cell migration, but that this stimulatory effect was markedly donor-dependent. MALDI-TOF/TOF mass spectrometry demonstrated that whilst collagen type I and fibronectin were secreted by all of the MSC cultures, the small leucine rich proteoglycan, decorin was secreted only by the MSC culture that was least effective upon EaHy-926 cells...
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/26195890/tendinopathies-and-platelet-rich-plasma-prp-from-pre-clinical-experiments-to-therapeutic-use
#15
Jean-François Kaux, Pierre Drion, Jean-Louis Croisier, Jean-Michel Crielaard
OBJECTIVES: The restorative properties of platelets, through the local release of growth factors, are used in various medical areas. This article reviews fundamental and clinical research relating to platelet-rich plasma applied to tendinous lesions. MATERIALS AND METHOD: Articles in French and English, published between 1 January 2012 and 31 December 2014. dealing with PRP and tendons were searched for using the Medline and Scopus data bases. RESULTS: Forty-seven articles were identified which addressed pre-clinical and clinical studies: 27 relating to in vitro and in vivo animal studies and 20 relating to human studies...
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/26195889/intricacies-of-pluripotency
#16
Deepa Bhartiya
Pluripotent stem cells have the potential to differentiate into 200 odd cell types present in adult body. Pluripotent stem cells available for regenerative medicine include embryonic stem (ES) cells, induced pluripotent stem (iPS) cells and very small ES-like stem (VSELs) cells. Nuclear OCT-4 is one of the crucial factors that dictate pluripotent state. Compared to ES/iPS cells grown in Petri dish, VSELs exist in adult body organs and results are emerging to suggest that they may have better potential to regenerate adult organs...
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/26195888/hypoxia-is-no-hype-perspectives-across-phylogeny-stem-cell-differentiation-geochemistry
#17
(no author information available yet)
No abstract text is available yet for this article.
2015: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/25705099/proceedings-of-the-inventions-inter-disciplinary-interactions-and-solutions-iidias-session
#18
(no author information available yet)
No abstract text is available yet for this article.
2014: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/25705098/proceedings-of-the-annual-plenary-session-on-regenerative-medicine-paprm
#19
(no author information available yet)
No abstract text is available yet for this article.
2014: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/25705097/adipose-stem-cell-microbeads-as-production-sources-for-chondrogenic-growth-factors
#20
Christopher S D Lee, Anthony M Nicolini, Elyse A Watkins, Olivia A Burnsed, Barbara D Boyan, Zvi Schwartz
Microencapsulating stem cells in injectable microbeads can enhance delivery and localization, but their ability to act as growth factor production sources is still unknown. To address this concern, growth factor mRNA levels and production from alginate microbeads with encapsulated human adipose stem cells (ASC microbeads) cultured in both growth and chondrogenic media (GM and CM) were measured over a two week period. Human ASCs in microbeads were either commercially purchased (Lonza) or isolated from six human donors and compared to human ASCs on tissue culture polystyrene (TCPS)...
2014: Journal of Stem Cells & Regenerative Medicine
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