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Nature and Science of Sleep

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https://www.readbyqxmd.com/read/28490912/update-on-the-treatment-of-narcolepsy-clinical-efficacy-of-pitolisant
#1
REVIEW
Michael W Calik
Narcolepsy is a neurological disease that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness (EDS). In 60-70% of individuals with narcolepsy, it is also characterized by cataplexy or a sudden loss of muscle tone that is triggered by positive or negative emotions. Narcolepsy decreases the quality of life of the afflicted individuals. Currently used drugs treat EDS alone (modafinil/armodafinil, methylphenidate, and amphetamine), cataplexy alone ("off-label" use of antidepressants), or both EDS and cataplexy (sodium oxybate)...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28490911/the-effect-of-physical-activity-on-sleep-quality-well-being-and-affect-in-academic-stress-periods
#2
Kathrin Wunsch, Nadine Kasten, Reinhard Fuchs
The stress-buffering hypothesis postulates that physical activity and exercise can buffer the negative effects of (academic) stress on health. It still remains an open question whether students, who regularly engage in physical activity and exercise within their academic examination period, can successfully diminish these negative effects. Sixty-four subjects participated in this study and completed a total of five surveys, with T1 at the end of the semester break (baseline) and T2-T5 being presented every Friday in the last 4 weeks of the semester (examination period)...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28442939/sleep-disturbance-linked-to-suicidal-ideation-in-postural-orthostatic-tachycardia-syndrome
#3
Cathy Lynn Pederson, Jill Blettner Brook
OBJECTIVE: We investigated the prevalence of suicidal ideation in relationship with symptoms of sleep disruption in people with postural orthostatic tachycardia syndrome (POTS). METHODS: Online surveys (including the Pittsburgh Sleep Quality Index and the Suicide Behaviors Questionnaire - Revised) were completed by 705 POTS patients and 170 non-POTS controls. RESULTS: Poor sleep quality was reported in 98.4% of POTS patients with a calculated subjective sleep efficiency of 65...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28424564/new-developments-in-the-management-of-narcolepsy
#4
REVIEW
Vivien C Abad, Christian Guilleminault
Narcolepsy is a life-long, underrecognized sleep disorder that affects 0.02%-0.18% of the US and Western European populations. Genetic predisposition is suspected because of narcolepsy's strong association with HLA DQB1*06-02, and genome-wide association studies have identified polymorphisms in T-cell receptor loci. Narcolepsy pathophysiology is linked to loss of signaling by hypocretin-producing neurons; an autoimmune etiology possibly triggered by some environmental agent may precipitate hypocretin neuronal loss...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28360539/alternative-remedies-for-insomnia-a-proposed-method-for-personalized-therapeutic-trials
#5
Kate Romero, Balaji Goparaju, Kathryn Russo, M Brandon Westover, Matt T Bianchi
Insomnia is a common symptom, with chronic insomnia being diagnosed in 5-10% of adults. Although many insomnia patients use prescription therapy for insomnia, the health benefits remain uncertain and adverse risks remain a concern. While similar effectiveness and risk concerns exist for herbal remedies, many individuals turn to such alternatives to prescriptions for insomnia. Like prescription hypnotics, herbal remedies that have undergone clinical testing often show subjective sleep improvements that exceed objective measures, which may relate to interindividual heterogeneity and/or placebo effects...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28331381/retrospective-nonrandomized-controlled-study-on-autoadjusting-dual-pressure-positive-airway-pressure-therapy-for-a-consecutive-series-of-complex-insomnia-disorder-patients
#6
Barry Krakow, Natalia D McIver, Victor A Ulibarri, Michael R Nadorff
PURPOSE: Emerging evidence shows that positive airway pressure (PAP) treatment of obstructive sleep apnea (OSA) and upper airway resistance syndrome (UARS) in chronic insomnia patients (proposed "complex insomnia" disorder) leads to substantial decreases in insomnia severity. Although continuous PAP (CPAP) is the pressure mode most widely researched, intolerance to fixed pressurized air is rarely investigated or described in comorbidity patients. This retrospective study examined dual pressure, autoadjusting PAP modes in chronic, complex insomnia disorder patients...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28331380/classical-conditioning-for-preserving-the-effects-of-short-melatonin-treatment-in-children-with-delayed-sleep-a-pilot-study
#7
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Frans J Oort
Melatonin treatment is effective in treating sleep onset problems in children with delayed melatonin onset, but effects usually disappear when treatment is discontinued. In this pilot study, we investigated whether classical conditioning might help in preserving treatment effects of melatonin in children with sleep onset problems, with and without comorbid attention deficit hyperactivity disorder (ADHD) or autism. After a baseline week, 16 children (mean age: 9.92 years, 31% ADHD/autism) received melatonin treatment for 3 weeks and then gradually discontinued the treatment...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28331379/smartphone-viewing-distance-and-sleep-an-experimental-study-utilizing-motion-capture-technology
#8
Michitaka Yoshimura, Momoko Kitazawa, Yasuhiro Maeda, Masaru Mimura, Kazuo Tsubota, Taishiro Kishimoto
There are studies reporting the negative impact of smartphone utilization on sleep. It is considered that reduction of melatonin secretion under the blue light exposure from smart-phone displays is one of the causes. The viewing distance may cause sleep disturbance, because the viewing distance determines the screen illuminance and/or asthenopia. However, to date, there has been no study closely investigating the impact of viewing distance on sleep; therefore, we sought to determine the relationship between smartphone viewing distance and subjective sleep status...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28260958/sleep-apnea-risk-and-subclinical-atherosclerosis-in-early-middle-aged-retired-national-football-league-players
#9
Faith S Luyster, Reginald E Dunn, Diane S Lauderdale, Mercedes R Carnethon, Andrew M Tucker, Robert A Vogel, Andrew E Lincoln, Kristen L Knutson, Elliot J Pellman, Patrick J Strollo
PURPOSE: Limited data from former National Football League (NFL) players suggest that obstructive sleep apnea (OSA) may be highly prevalent after retirement. It remains unclear whether the high prevalence of OSA in retired players is comparable to nonathletes. This retrospective analysis compared sleep apnea (SA) risk in retired NFL players to a community cohort (CARDIA Sleep study), and examined associations between SA risk and cardiovascular risk factors, including subclinical atherosclerosis...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28243157/big-data-in-sleep-medicine-prospects-and-pitfalls-in-phenotyping
#10
Matt T Bianchi, Kathryn Russo, Harriett Gabbidon, Tiaundra Smith, Balaji Goparaju, M Brandon Westover
Clinical polysomnography (PSG) databases are a rich resource in the era of "big data" analytics. We explore the uses and potential pitfalls of clinical data mining of PSG using statistical principles and analysis of clinical data from our sleep center. We performed retrospective analysis of self-reported and objective PSG data from adults who underwent overnight PSG (diagnostic tests, n=1835). Self-reported symptoms overlapped markedly between the two most common categories, insomnia and sleep apnea, with the majority reporting symptoms of both disorders...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28243156/an-investigation-of-the-longitudinal-relationship-between-sleep-and-depressed-mood-in-developing-teens
#11
Nicole Lovato, Michelle A Short, Gorica Micic, Rachel M Hiller, Michael Gradisar
OBJECTIVE: The prospective, bidirectional relationship between sleep disturbance and depressed mood was assessed in a school-based sample of adolescents. METHOD: One hundred and thirty-eight Australian adolescents (mean age time 1 =15.69, standard deviation =0.92; 64% male) completed questionnaires to assess sleep parameters and depressed mood, on two occasions over 1 year. RESULTS: Cross-sectional associations were observed between depressed mood and sleep duration, as well as wakefulness in bed...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28053562/erratum-unihemispheric-sleep-and-asymmetrical-sleep-behavioral-neurophysiological-and-functional-perspectives-corrigendum
#12
(no author information available yet)
[This corrects the article on p. 221 in vol. 8, PMID: 27471418.].
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27920587/defining-the-rest-interval-associated-with-the-main-sleep-period-in-actigraph-scoring
#13
Chin Moi Chow, Shi Ngar Wong, Mirim Shin, Rebecca G Maddox, Kristy-Lee Feilds, Karen Paxton, Catherine Hawke, Philip Hazell, Katharine Steinbeck
Actigraphy is increasingly used for sleep monitoring. However, there is a lack of standardized methodology for data processing and analysis, which often makes between study comparisons difficult, if not impossible, and thus open to flawed interpretation. This study evaluated a manual method for detection of the rest interval in actigraph data collected with Actiwatch 2. The rest interval (time in bed), defined as the bedtime and rise time and set by proprietary software, is an essential requirement for the estimation of sleep indices...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27920586/the-relation-between-sleep-and-weight-in-a-suburban-sleep-center-observations-and-speculations-on-apnea-and-weight
#14
Robert G Hooper
STUDY OBJECTIVES: The relationship between obstructive sleep apnea (OSA) and body weight is not clearly established. In order to describe the relationship of weight and OSA severity seen in a suburban sleep center, an observational review was performed of initial diagnostic polysomnograms (PSGs) ordered on patients with American Academy of Sleep Medicine (AASM) symptomatic indications. METHODOLOGY/PRINCIPLE FINDINGS: Initial, full-night diagnostic or initial split-night (diagnostic portion) PSGs performed for any indication on patients >18 years old were retrospectively reviewed for a two year period...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27895522/effects-of-tai-chi-chuan-on-anxiety-and-sleep-quality-in-young-adults-lessons-from-a-randomized-controlled-feasibility-study
#15
Karen L Caldwell, Shawn M Bergman, Scott R Collier, N Travis Triplett, Rebecca Quin, John Bergquist, Carl F Pieper
OBJECTIVE: To determine feasibility and estimate the effect of a 10-week tai chi chuan (TCC) intervention on anxiety and sleep quality in young adults. PARTICIPANTS: Seventy-five adults (18-40 years) from a predominately undergraduate midsized university. METHODS: This was an assessor blinded, randomized feasibility trial, and participants were randomized into one of three groups: 10 weeks of TCC meeting 2 times per week, 10 weeks of TCC with a DVD of the curriculum, and control group receiving a handout on anxiety management...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27757056/epiglottis-cross-sectional-area-and-oropharyngeal-airway-length-in-male-and-female-obstructive-sleep-apnea-patients
#16
Melinda A Ma, Rajesh Kumar, Paul M Macey, Frisca L Yan-Go, Ronald M Harper
INTRODUCTION: Obstructive sleep apnea (OSA) is a male-predominant condition, characterized by repeated upper-airway collapse with continued diaphragmatic efforts during sleep, and is accompanied by severe physiological consequences. Multiple morphological aspects, including epiglottis cross-sectional area (CSA) and oropharyngeal airway length (OPAL), can contribute to airway collapsibility in the condition. This study focused on the effects of OSA severity, sex, and race on OPA dimensions...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27574478/hypnotic-effect-of-the-essential-oil-from-the-leaves-of-myrtus-communis-on-mice
#17
Muluken Walle Birhanie, Bizuayehu Walle, Kidist Rebba
BACKGROUND: Myrtus communis has been suggested as a sleep aid in unconventional medicine. Moreover, previous studies have also indicated its sedative- and hypnotic-like activity. In this study, the hypnotic effect of M. communis was investigated. METHODS: Essential oil (EO) of M. communis (600, 800, and 1,000 mg/kg) was given orally to Swiss albino mice of both sex, and the hypnotic effect was evaluated. In addition, the EO of M. communis (500, 600, 800, and 1,000 mg/kg) was administered orally to Swiss albino mice of both sex 60 minutes prior to pentobarbital injection (50 mg/kg)...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27570468/subjective-sleep-complaints-indicate-objective-sleep-problems-in-psychosomatic-patients-a-prospective-polysomnographic-study
#18
Michael Linden, Marie Dietz, Christian Veauthier, Ingo Fietze
OBJECTIVE: To elucidate the relationship between subjective complaints and polysomnographical parameters in psychosomatic patients. METHOD: A convenience sample of patients from a psychosomatic inpatient unit were classified according to the Pittsburgh Sleep Quality Index (PSQI) as very poor sleepers (PSQI >10, n=80) and good sleepers (PSQI <6, n=19). They then underwent a polysomnography and in the morning rated their previous night's sleep using a published protocol (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin morning protocol [MP])...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27555802/clinical-predictors-of-central-sleep-apnea-evoked-by-positive-airway-pressure-titration
#19
Marilyn Moro, Karen Gannon, Kathy Lovell, Margaret Merlino, James Mojica, Matt T Bianchi
PURPOSE: Treatment-emergent central sleep apnea (TECSA), also called complex apnea, occurs in 5%-15% of sleep apnea patients during positive airway pressure (PAP) therapy, but the clinical predictors are not well understood. The goal of this study was to explore possible predictors in a clinical sleep laboratory cohort, which may highlight those at risk during clinical management. METHODS: We retrospectively analyzed 728 patients who underwent PAP titration (n=422 split-night; n=306 two-night)...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27540316/periodic-limb-movements-of-sleep-empirical-and-theoretical-evidence-supporting-objective-at-home-monitoring
#20
Marilyn Moro, Balaji Goparaju, Jelina Castillo, Yvonne Alameddine, Matt T Bianchi
INTRODUCTION: Periodic limb movements of sleep (PLMS) may increase cardiovascular and cerebrovascular morbidity. However, most people with PLMS are either asymptomatic or have nonspecific symptoms. Therefore, predicting elevated PLMS in the absence of restless legs syndrome remains an important clinical challenge. METHODS: We undertook a retrospective analysis of demographic data, subjective symptoms, and objective polysomnography (PSG) findings in a clinical cohort with or without obstructive sleep apnea (OSA) from our laboratory (n=443 with OSA, n=209 without OSA)...
2016: Nature and Science of Sleep
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