journal
MENU ▼
Read by QxMD icon Read
search

Stem Cells and Cloning: Advances and Applications

journal
https://www.readbyqxmd.com/read/30233218/sirt1-protects-neural-stem-cells-from-apoptosis-by-decreasing-acetylation-of-histone-3k9
#1
Chongdong Jian, Cuihua Zou, Ning Xu, Guoying Chen, Donghua Zou
Objective: To explore the role and mechanism of Sirt1 in protecting neural stem cells (NSCs) from apoptosis. Materials and methods: Transfection was used to overexpress Sirt1 in rat NSCs. The effect of Sirt1 overexpression on camptothecin-induced apoptosis of NSCs was evaluated. Western blotting was used to examine the expression of Sirt1, cleaved caspase-3, and acetylated histone 3K9. Results: Overexpression of Sirt1 in NSCs decreased the cleavage of caspase-3 and acetylation of histone 3K9...
2018: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/30013372/cryostorage-of-immature-and-mature-human-testis-tissue-to-preserve-spermatogonial-stem-cells-sscs-a-systematic-review-of-current-experiences-toward-clinical-applications
#2
REVIEW
Nima Pourhabibi Zarandi, Guillermo Galdon, Stanley Kogan, Anthony Atala, Hooman Sadri-Ardekani
While the survival rate of children with cancer is increasing, preserving fertility for prepubertal boys is still a challenge. Although intracytoplasmic sperm injection (ICSI) using frozen sperms has revolutionized infertility treatment, it is not applicable for the patients who undergo chemotherapy before puberty since spermatogenesis has not begun. Therefore, preserving spermatogonial stem cells (SSCs) as an experimental option can be provided to prepubertal patients at a risk of damage or loss of their SSCs due to cancer treatments and developmental or genetic disorders...
2018: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/29497320/bone-marrow-mesenchymal-stem-cells-as-nuclear-donors-improve-viability-and-health-of-cloned-horses
#3
R Olivera, L N Moro, R Jordan, N Pallarols, A Guglielminetti, C Luzzani, S G Miriuka, G Vichera
Introduction: Cell plasticity is crucial in cloning to allow an efficient nuclear reprogramming and healthy offspring. Hence, cells with high plasticity, such as multipotent mesenchymal stem cells (MSCs), may be a promising alternative for horse cloning. In this study, we evaluated the use of bone marrow-MSCs (BM-MSCs) as nuclear donors in horse cloning, and we compared the in vitro and in vivo embryo development with respect to fibroblasts. Materials and methods: Zona-free nuclear transfer was performed using BM-MSCs (MSC group, n=3432) or adult fibroblasts (AF group, n=4527)...
2018: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/29483778/a-review-on-stem-cell-therapy-for-multiple-sclerosis-special-focus-on-human-embryonic-stem-cells
#4
REVIEW
Geeta Shroff
Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its management are able to slow down the progression but fail to treat it completely. Moreover, these therapies are associated with major CNS and cardiovascular adverse events, and prolonged use of these treatments may cause life-threatening diseases. Recent research has shown that cellular therapies hold a potential for CNS repair and may be able to provide protection from inflammatory damage caused after injury...
2018: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/29033593/expression-profiling-of-adhesion-proteins-during-prenatal-and-postnatal-liver-development-in-rats
#5
Mehwish Yousaf, Asima Tayyeb, Gibran Ali
Culturing of primary hepatocytes and stem cell-derived hepatocytes faces a major issue of dedifferentiation due to absence of cell-cell adhesion and 3D structures. One of the possible ways to eliminate the problem of dedifferentiation is mimicking the expression pattern of adhesion proteins during the normal developmental process of liver cells. The purpose of this study was to evaluate the expression pattern of some key adhesion proteins, namely, E-cadherin, N-cadherin, epithelial CAM (EpCAM), intracellular CAM (ICAM), collagen 1α1, α-actinin, β-catenin and vimentin, in the liver tissue during prenatal and postnatal stages...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28979149/conventional-and-novel-stem-cell-based-therapies-for-androgenic-alopecia
#6
REVIEW
Dodanim Talavera-Adame, Daniella Newman, Nathan Newman
The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28740409/hair-follicle-growth-by-stromal-vascular-fraction-enhanced-adipose-transplantation-in-baldness
#7
David Perez-Meza, Craig Ziering, Marcos Sforza, Ganesh Krishnan, Edward Ball, Eric Daniels
Great interest remains in finding new and emerging therapies for the treatment of male and female pattern hair loss. The autologous fat grafting technique is >100 years old, with a recent and dramatic increase in clinical experience over the past 10-15 years. Recently, in 2001, Zuk et al published the presence of adipose-derived stem cells, and abundant research has shown that adipose is a complex, biological active, and important tissue. Festa et al, in 2011, reported that adipocyte lineage cells support the stem cell niche and help drive the complex hair growth cycle...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/27217783/stem-cell-technology-in-breast-cancer-current-status-and-potential-applications
#8
REVIEW
Rena Chiotaki, Hara Polioudaki, Panayiotis A Theodoropoulos
Breast cancer, the leading cause of cancer among females, is supported by the presence of a rare subset of undifferentiated cells within the tumor, identified as breast cancer stem cells (BCSCs). BCSCs underlie the mechanisms of tumor initiation and sustenance and are implicated in the dissemination of the primary tumor to metastatic sites, as they have been found circulating in the blood of breast cancer patients. The discovery of BCSCs has generated a great amount of interest among the scientific community toward their isolation, molecular characterization, and therapeutic targeting...
2016: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/27143939/characterization-of-neural-stemness-status-through-the-neurogenesis-process-for-bone-marrow-mesenchymal-stem-cells
#9
Maeda H Mohammad, Ahmed M Al-Shammari, Ahmad Adnan Al-Juboory, Nahi Y Yaseen
The in vitro isolation, identification, differentiation, and neurogenesis characterization of the sources of mesenchymal stem cells (MSCs) were investigated to produce two types of cells in culture: neural cells and neural stem cells (NSCs). These types of stem cells were used as successful sources for the further treatment of central nervous system defects and injuries. The mouse bone marrow MSCs were used as the source of the stem cells in this study. β-Mercaptoethanol (BME) was used as the main inducer of the neurogenesis pathway to induce neural cells and to identify NSCs...
2016: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/26715856/stem-cell-technology-for-tendon-regeneration-current-status-challenges-and-future-research-directions
#10
REVIEW
Pauline Po Yee Lui
Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their high proliferative, synthetic, and immunomodulatory activities as well as their potential to differentiate to the target cell types and undergo genetic modification...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/26604802/human-adipose-stem-cell-and-asc-derived-cardiac-progenitor-cellular-therapy-improves-outcomes-in-a-murine-model-of-myocardial-infarction
#11
Philip Mc Davy, Kevin D Lye, Juanita Mathews, Jesse B Owens, Alice Y Chow, Livingston Wong, Stefan Moisyadi, Richard C Allsopp
BACKGROUND: Adipose tissue is an abundant and potent source of adult stem cells for transplant therapy. In this study, we present our findings on the potential application of adipose-derived stem cells (ASCs) as well as induced cardiac-like progenitors (iCPs) derived from ASCs for the treatment of myocardial infarction. METHODS AND RESULTS: Human bone marrow (BM)-derived stem cells, ASCs, and iCPs generated from ASCs using three defined cardiac lineage transcription factors were assessed in an immune-compromised mouse myocardial infarction model...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/26586955/from-bench-to-bedside-use-of-human-adipose-derived-stem-cells
#12
REVIEW
Vaughan Feisst, Sarah Meidinger, Michelle B Locke
Since the discovery of adipose-derived stem cells (ASC) in human adipose tissue nearly 15 years ago, significant advances have been made in progressing this promising cell therapy tool from the laboratory bench to bedside usage. Standardization of nomenclature around the different cell types used is finally being adopted, which facilitates comparison of results between research groups. In vitro studies have assessed the ability of ASC to undergo mesenchymal differentiation as well as differentiation along alternate lineages (transdifferentiation)...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/26451119/mesenchymal-and-induced-pluripotent-stem-cells-general-insights-and-clinical-perspectives
#13
REVIEW
Helena D Zomer, Atanásio S Vidane, Natalia N Gonçalves, Carlos E Ambrósio
Mesenchymal stem cells have awakened a great deal of interest in regenerative medicine due to their plasticity, and immunomodulatory and anti-inflammatory properties. They are high-yield and can be acquired through noninvasive methods from adult tissues. Moreover, they are nontumorigenic and are the most widely studied. On the other hand, induced pluripotent stem (iPS) cells can be derived directly from adult cells through gene reprogramming. The new iPS technology avoids the embryo destruction or manipulation to generate pluripotent cells, therefore, are exempt from ethical implication surrounding embryonic stem cell use...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/26357483/mesenchymal-stem-cell-therapy-for-osteoarthritis-current-perspectives
#14
REVIEW
Cody C Wyles, Matthew T Houdek, Atta Behfar, Rafael J Sierra
Osteoarthritis (OA) is a painful chronic condition with a significant impact on quality of life. The societal burden imposed by OA is increasing in parallel with the aging population; however, no therapies have demonstrated efficacy in preventing the progression of this degenerative joint disease. Current mainstays of therapy include activity modification, conservative pain management strategies, weight loss, and if necessary, replacement of the affected joint. Mesenchymal stem cells (MSCs) are a multipotent endogenous population of progenitors capable of differentiation to musculoskeletal tissues...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/26251620/progress-toward-curing-hiv-infection-with-hematopoietic-cell-transplantation
#15
REVIEW
Lawrence D Petz, John C Burnett, Haitang Li, Shirley Li, Richard Tonai, Milena Bakalinskaya, Elizabeth J Shpall, Sue Armitage, Joanne Kurtzberg, Donna M Regan, Pamela Clark, Sergio Querol, Jonathan A Gutman, Stephen R Spellman, Loren Gragert, John J Rossi
HIV-1 infection afflicts more than 35 million people worldwide, according to 2014 estimates from the World Health Organization. For those individuals who have access to antiretroviral therapy, these drugs can effectively suppress, but not cure, HIV-1 infection. Indeed, the only documented case for an HIV/AIDS cure was a patient with HIV-1 and acute myeloid leukemia who received allogeneic hematopoietic cell transplantation (HCT) from a graft that carried the HIV-resistant CCR5-∆32/∆32 mutation. Other attempts to establish a cure for HIV/AIDS using HCT in patients with HIV-1 and malignancy have yielded mixed results, as encouraging evidence for virus eradication in a few cases has been offset by poor clinical outcomes due to the underlying cancer or other complications...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/26185458/embryonic-maternal-cross-talk-via-exosomes-potential-implications
#16
Islam M Saadeldin, Hyun Ju Oh, Byeong Chun Lee
A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic-maternal cross-talk. In this mini-review, we focused on the exosomes, which are cell-derived vesicles of 30-100 nm in diameter, as a communicating language facilitating this dialog. These nanovesicles are secreted from pre-implantation embryos, oviduct epithelium, and endometrium as well as from the placenta, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes, and have pleiotropic effects on both embryonic and maternal environments...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/25999743/cardiac-tissue-engineering-and-regeneration-using-cell-based-therapy
#17
REVIEW
Mohammad T Alrefai, Divya Murali, Arghya Paul, Khalid M Ridwan, John M Connell, Dominique Shum-Tim
Stem cell therapy and tissue engineering represent a forefront of current research in the treatment of heart disease. With these technologies, advancements are being made into therapies for acute ischemic myocardial injury and chronic, otherwise nonreversible, myocardial failure. The current clinical management of cardiac ischemia deals with reestablishing perfusion to the heart but not dealing with the irreversible damage caused by the occlusion or stenosis of the supplying vessels. The applications of these new technologies are not yet fully established as part of the management of cardiac diseases but will become so in the near future...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/25960670/regulators-of-pluripotency-and-their-implications-in-regenerative-medicine
#18
REVIEW
Ahmed El-Badawy, Nagwa El-Badri
The ultimate goal of regenerative medicine is to replace damaged tissues with new functioning ones. This can potentially be accomplished by stem cell transplantation. While stem cell transplantation for blood diseases has been increasingly successful, widespread application of stem cell therapy in the clinic has shown limited results. Despite successful efforts to refine existing methodologies and to develop better ones for reprogramming, clinical application of stem cell therapy suffers from issues related to the safety of the transplanted cells, as well as the low efficiency of reprogramming technology...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/25926746/regenerative-medicine-in-the-treatment-of-idiopathic-pulmonary-fibrosis-current-position
#19
REVIEW
Diana Álvarez, Melanie Levine, Mauricio Rojas
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible disease of the lung that has no lasting option for therapy other than transplantation. It is characterized by replacement of the normal lung tissue by fibrotic scarring, honeycombing, and increased levels of myofibroblasts. The underlying causes of IPF are still largely unknown. The focus of the current review is the possible use of stem cell therapy, specifically mesenchymal stem cells (MSCs), a multipotent stromal cell population, which have demonstrated promising data in multiple animal models of pulmonary fibrosis (PF)...
2015: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/25848307/postnatal-oogenesis-in-humans-a-review-of-recent-findings
#20
REVIEW
Irma Virant-Klun
In spite of generally accepted dogma that the total number of follicles and oocytes is established in human ovaries during the fetal period of life rather than forming de novo in adult ovaries, some new evidence in the field challenges this understanding. Several studies have shown that different populations of stem cells, such as germinal stem cells and small round stem cells with diameters of 2 to 4 μm, that resembled very small embryonic-like stem cells and expressed several genes related to primordial germ cells, pluripotency, and germinal lineage are present in adult human ovaries and originate in ovarian surface epithelium...
2015: Stem Cells and Cloning: Advances and Applications
journal
journal
47165
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"