journal
https://read.qxmd.com/read/25512709/bioinformatic-dissecting-of-tp53-regulation-pathway-underlying-butyrate-induced-histone-modification-in-epigenetic-regulation
#21
JOURNAL ARTICLE
Cong-Jun Li, Robert W Li
Butyrate affects cell proliferation, differentiation, and motility. Butyrate inhibits histone deacetylase (HDAC) activities and induces cell-cycle arrest and apoptosis. TP53 is one of the most active upstream regulators discovered by ingenuity pathways analysis (IPA) in our RNA-sequencing data set. TP53 signaling pathway plays key role in many cellular processes. TP53 pathway and their involvement in cellular functions modified by butyrate treatment were scrutinized in this report by data mining the RNA-sequencing data using IPA (Ingenuity System(®))...
2014: Genetics & Epigenetics
https://read.qxmd.com/read/25512708/epigenetics-of-autoantigens-new-opportunities-for-therapy-of-autoimmune-diseases
#22
REVIEW
Marko Radic, Sylviane Muller
The field of epigenetics requires that traditional divisions between scientific disciplines give way to cross-fertilization of concepts and ideas from different areas of investigation. Such is the case with research in autoimmunity. Recent discoveries of stimuli that induce autoimmunity reveal that epigenetic marks of autoantigens are recognized by autoreactive B and T cell receptors. Thus, insights into the initiation of autoimmunity, its prevention and therapy will arise from understanding the biochemistry, cell biology and microbiology of autoantigen epigenetics...
2013: Genetics & Epigenetics
https://read.qxmd.com/read/25512707/changes-in-methylation-patterns-of-kiss1-and-kiss1r-gene-promoters-across-puberty
#23
JOURNAL ARTICLE
Amanda K Wyatt, Monika Zavodna, Jean L Viljoen, Jo-Ann L Stanton, Neil J Gemmell, Christine L Jasoni
The initiation of mammalian puberty is underpinned by an increase in Kisspeptin (Kiss1) signaling via its receptor (Kiss1r/GPR54) on gonadotropin-releasing hormone (GnRH) neurons. Animals and humans with loss-of-function mutations in Kiss1 or Kiss1r fail to go through puberty. The timing of puberty is dependent on environmental factors, and malleability in puberty timing suggests a mechanism that can translate environmental signals into patterns of Kiss1/Kiss1r gene expression. Epigenetics is a powerful mechanism that can control gene expression in an environment-dependent manner...
2013: Genetics & Epigenetics
https://read.qxmd.com/read/25512706/dna-demethylation-pathways-recent-insights
#24
REVIEW
Cong-Jun Li
DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell differentiation. Until recently, it was still unclear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether or not active demethylating activity is involved. Even the role of molecules and the mechanisms underlying the processes of active demethylation itself is blurred. Emerging sequencing technologies have led to recent insights into the dynamic distribution of DNA methylation during development and the role of this epigenetic mark within a distinct genome context, such as the promoters, exons, or imprinted control regions...
2013: Genetics & Epigenetics
https://read.qxmd.com/read/25512705/unexplored-potentials-of-epigenetic-mechanisms-of-plants-and-animals-theoretical-considerations
#25
REVIEW
Istvan Seffer, Zoltan Nemeth, Gyula Hoffmann, Robert Matics, A Gergely Seffer, Akos Koller
Morphological and functional changes of cells are important for adapting to environmental changes and associated with continuous regulation of gene expressions. Genes are regulated-in part-by epigenetic mechanisms resulting in alternating patterns of gene expressions throughout life. Epigenetic changes responding to the environmental and intercellular signals can turn on/off specific genes, but do not modify the DNA sequence. Most epigenetic mechanisms are evolutionary conserved in eukaryotic organisms, and several homologs of epigenetic factors are present in plants and animals...
2013: Genetics & Epigenetics
https://read.qxmd.com/read/25512704/loss-of-imprinting-of-igf2-gene-in-the-chorionic-tissues-of-spontaneously-eliminated-human-embryos
#26
JOURNAL ARTICLE
Danuta Zastavna, Halyna Makukh, Bogdan Tretjak, Olena Bilevych, Miroslaw Tyrka
Insulin-like growth factor-2 (IGF-2) is a mitogen, growth and differentiation modulator for many cell types. It is mainly expressed during the prenatal development, and its activity strongly depends on the genomic imprinting. Genomic imprinting in the chorionic tissues of spontaneously eliminated human embryos has been studied on the model of 820-AG (Apa1) of the IGF-2 gene locus. Molecular and genetic analysis was performed on the polymorphic 820-AG IGF2 locus in 107 samples of DNA extracted from the chorionic tissues of spontaneously eliminated human embryos within 5-10 weeks of gestation...
2013: Genetics & Epigenetics
https://read.qxmd.com/read/25512703/epigenetic-effect-of-chronic-stress-on-dopamine-signaling-and-depression
#27
REVIEW
Sofia Moriam, Mahbub E Sobhani
Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, including motor control, mood, and the reward pathway. These factors lead many drugs to target Dopamine receptors in treating depressive disorders. In this review, we try to portray how chronic stress as an epigenetic factor changes the gene regulation pattern by interrupting Dopamine signaling mechanism...
2013: Genetics & Epigenetics
https://read.qxmd.com/read/25512702/acute-psychosocial-stress-mediated-changes-in-the-expression-and-methylation-of-perforin-in-chronic-fatigue-syndrome
#28
JOURNAL ARTICLE
Virginia R Falkenberg, Toni Whistler, Janna R Murray, Elizabeth R Unger, Mangalathu S Rajeevan
Perforin (PRF1) is essential for immune surveillance and studies report decreased perforin in chronic fatigue syndrome (CFS), an illness potentially associated with stress and/or infection. We hypothesize that stress can influence regulation of PRF1 expression, and that this regulation will differ between CFS and non-fatigued (NF) controls. We used the Trier Social Stress Test (TSST) as a standardized acute psychosocial stress, and evaluated its effect on PRF1 expression and methylation in CFS (n = 34) compared with NF (n = 47) participants...
2013: Genetics & Epigenetics
1
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.