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Iranian Journal of Basic Medical Sciences

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https://www.readbyqxmd.com/read/29238476/anti-hyperglycemic-and-antioxidant-potential-of-croton-bonplandianus-bail-fractions-in-correlation-with-polyphenol-content
#1
Uma Dharshini Karuppiah Vijayamuthuramalingam, Rajeswari Rajaram, Kalaivani Madhavaram Kuppusamy, Bhavana Jonnalagadda, Sumathy Arokiasamy
Objectives: Diabetes mellitus, a carbohydrate metabolic disorder, occurs due to absolute or relative deficiency of insulin. Current treatment strategies involve either preventing or delaying the intestinal absorption of glucose to lower the levels of postprandial hyperglycemia (PPHG). Herbal remedies have been since ancient times for treating diabetes mellitus. Therefore, identifying novel phytocompounds with α-amylase and α-glucosidase inhibitory activity that would reduce the glucose absorption as well as the rise in postprandial blood glucose level is vital...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238475/sodium-hydrosulfide-upregulates-mrna-and-protein-expression-of-tgf-%C3%AE-in-gastric-mucosa-in-experimental-model-of-stimulated-gastric-acid-secretion-in-rats
#2
Ghaidafeh Akbari, Seyed Ali Mard, Seyed Esmaeil Khoshnam, Iraj Ahmadi
Objectives: Transforming growth factor alpha (TGF-α) has been shown to modulate the gastric acid secretion. Therefore, the aim of the present study was to investigate the effect of sodium hydrosulfide (NaHS) on TGF-α expression in gastric mucosa in rats. Materials and Methods: Eighteen rats were randomly divided into 3 groups (6 per group). To determine the effect of NaHS on gene and protein expression of TGF-α in gastric mucosa in response to gastric acid, the acid output induced by gastric distension...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238474/cytotoxic-and-apoptotic-effects-of-root-extract-and-tanshinones-isolated-from-perovskiaabrotanoides-kar
#3
Arehzoo Zaker, Javad Asili, Parvaneh Abrishamchi, Zahra Tayarani-Najaran, Seyed Hadi Mousavi
Objectives: Perovskiaabrotanoides Kar., from family Lamiaceae, is a little known medicinal plant growing in various regions of Iran. In the present study, cryptotanshinone (CT), tanshinone 2A (Tan2A), and hydroxycryptotanshinone (HCT) were isolated and purified from the roots of P. abrotanoides. In addition, cytotoxic and apoptotic effects of total root extract (TE) and three purified tanshinones were investigated in human cervical carcinoma (HeLa) and human breast cancer (MCF-7) cell lines...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238473/the-effects-of-cck-8s-on-spatial-memory-and-long-term-potentiation-at-ca1-during-induction-of-stress-in-rats
#4
Malihe Sadeghi, Parham Reisi, Maryam Radahmadi
Objectives: Cholecystokinin (CCK) has been proposed as a mediator in stress. However, it is still not fully documented what are its effects. We aimed to evaluate the effects of systemic administration of CCK exactly before induction of stress on spatial memory and synaptic plasticity at CA1 in rats. Materials and Methods: Male Wistar rats were divided into 4 groups: the control, the control-CCK, the stress and the stress-CCK. Restraint stress was induced 6 hr per day, for 24 days...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238472/vitamin-e-improved-bone-strength-and-bone-minerals-in-male-rats-given-alcohol
#5
Syuhada Zakaria, Siti-Zulaikha Mat-Husain, Kong Ying-Hwey, Kek Xin-Kai, Abdullah Mohd-Badawi, Nurul-Amiza Abd-Ghani, Muhamad-Arizi Aziz, Norazlina Mohamed
Objectives: Alcohol consumption induces oxidative stress on bone, which in turn increases the risk of osteoporosis. This study determined the effects of vitamin E on bone strength and bone mineral content in alcohol-induced osteoporotic rats. Materials and Methods: Three months old Sprague Dawley male rats were randomly divided into 5 groups: (I) control group; (II) alcohol (3g/kg) + normal saline; (III) alcohol (3g/kg) + olive oil; (IV) alcohol (3g/kg) + alpha-tocopherol (60mg/kg) and (V) alcohol (3g/kg) + palm vitamin E (60mg/kg)...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238471/the-effects-of-specific-expression-of-apoptin-under-the-control-of-pses-and-psa-promoter-on-cell-death-and-apoptosis-of-lncap-cells
#6
Vida Mohammadi, Abbas Behzad Behbahani, Gholam Reza Rafiee, Seyed Younes Hosseini, Marzieh Alizadeh Zarei, Mohammad Ali Okhovat, Mohammad Ali Takhshid
Objectives: Apoptotic effect of apoptin has been demonstrated in numerous studies. However, its tumor specificity has been questioned by some reports. The aim of this study was to confine the expression of apoptin in the prostate tumor cells by inducing its gene expression under the control of a chimeric enhancer composing of prostate-specific membrane antigen (PSMA) and prostate-specific antigen (PSA) regulatory elements (PSES). Furthermore, we investigated the effects of apoptin expression on LNCaP prostate carcinoma cell survival and apoptosis using MTT assay and annexin V/7-AAD flow cytometry assay...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238470/the-effects-of-activated-omental-extract-on-nuclear-and-cytoplasmic-in-vitro-maturation-of-rat-oocytes
#7
Fakhroddin Mesbah, Aris Donic Pracha, Tahereh Talaei-Khozani, Soghra Bahmanpour
Objective: The role of growth factors, including vascular endothelial growth factor of activated omentum on mitosis is clearly known, though not on all the aspects of in vitro oocyte maturation. This study was designed to assess the effect of activated-omental extract (AOE) on in vitro maturation (IVM) of rat cumulus-oocyte complexes (COCs). Materials and Methods: In this experimental study, the COCs were incubated in Ham's F-10 supplemented with either 20% AOE, 20% fetal bovine serum (FBS) or serum-free media...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238469/the-role-of-sirolimus-in-proteinuria-in-diabetic-nephropathy-rats
#8
JinJun Wang, ZiQiang Xu, BiCheng Chen, ShaoLing Zheng, Peng Xia, Yong Cai
Objectives: The aim of this study was to observe the impact of sirolimus on proteinuria in streptozotocin (STZ) induced diabetic rats. Materials and Methods: Rats were given a single injection of STZ to induce diabetic rat model. Rats' 24 hr urine was collected to test, urinary and the kidney tissues were harvested at the 8th and 20th weeks, respectively. Podocyte morphological changes were examined by electron microscopy and the ZO-1, podocin expressions in kidneys were detected by immunohistochemistry; the protein levels of Raptor and pS6 were measured by Western blot assay...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238468/effect-of-fetal-and-adult-bovine-serum-on-pyocyanin-production-in-pseudomonas-aeruginosa-isolated-from-clinical-and-soil-samples
#9
Aylin Moayedi, Jamileh Nowroozi, Abbas Akhavan Sepahy
Objectives: Pyocyanin is a blue-greenish redox-active pigment, produced by Pseudomonas aeruginosa, with a wide range of biological and biotechnological applications. Pyocyanin biosynthesis is regulated by the quorum-sensing (QS) system in which the expression of QS genes and QS-controlled virulence genes may be affected by serum as a complex medium. In the current study, effects of adult bovine serum (ABS) and fetal bovine serum (FBS) on the production of pyocyanin were examined in order to develop it...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238467/neuroprotection-of-a-sesamin-derivative-1-2-bis-3-methoxyphenyl-methyl-ethane-1-2-dicaroxylic-acid-mmeda-against-ischemic-and-hypoxic-neuronal-injury
#10
Chang-Tsen Hung, Li-Dian Chen, Chien-Wei Hou
Objectives: Stroke may cause severe neuronal damage. The sesamin have been demonstrated to possess neuroprotection by its antioxidant and anti-inflammatory properties. One sesamin derivative was artificially composited, 1, 2-bis [(3-methoxyphenyl) methyl] ethane-1, 2-dicaroxylic acid (MMEDA) had been developed to study its antioxidative activity and neuroprotection. Materials and Methods: The infaction of Sprague Dawley (SD) rats and hypoxia models of BV-2 microglia or PC12 cells were investigated for in vivo and in vitro test respectively...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238466/antimalarial-and-cytotoxic-activities-of-roots-and-fruits-fractions-of-astrodaucus-persicus-extract
#11
Saied Goodarzi, Mehdi Nateghpour, Parina Asgharian, Abbas Hadjiakhoondi, Narguess Yassa, Saeed Tavakoli, Jalal Mirzaei, Leila Farivar, Afsaneh Motevalli Haghi, Zahra Tofighi
Objectives: Astrodaucus persicus (Apiaceae) is one of the two species of this genus which grows in different parts of Iran. Roots of this plant were rich in benzodioxoles and used as food additive or salad in Iran and near countries. The aim of present study was evaluation of antimalarial and cytotoxic effects of different fractions of A. persicus fruits and roots extracts. Materials and Methods: Ripe fruits and roots of A. persicus were extracted and fractionated by hexane, chloroform, ethyl acetate and methanol, separately...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238465/genistein-preserves-the-lungs-of-ovariectomized-diabetic-rats-addition-to-apoptotic-and-inflammatory-markers-in-the-lung
#12
Faeze Daghigh, Alireza Alihemmati, Pouran Karimi, Parisa Habibi, Naser Ahmadiasl
Objectives: The role of isoflavones in pulmonary structure and function during menopause is not well studied. Moreover, the important role of estrogen in the physiological function of respiratory system has been revealed. Genistein, as an isoflavone, mimics estrogenic in diabetic and ovariectomized rats. Here, we hypothesized that genistein would reverse changes in the protein expression levels related to estrogen deficiency in the lung of ovariectomized diabetic rats. Materials and Methods: Wistar female rats were assigned to four experimental groups (n=10 in each group): sham, rats underwent laparotomy without removing the ovaries; OVX, rats that underwent ovariectomy; OVX...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238464/curcumin-enhances-liver-sirt3-expression-in-the-rat-model-of-cirrhosis
#13
Sara Chenari, Fatemeh Safari, Ali Moradi
Objectives: Bill duct ligation (BDL) is a representative model of biliary cholestasis in animals. Curcumin has a protective effect on the liver; however, its underlying mechanisms are not completely known. This study explored the hepatoprotective activity of curcumin on hepatic damage via measuring the expression of sirtuin3 (SIRT3), AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase 1A (CPT-1A), isocitrate dehydrogenase2 (IDH2) and manganese superoxide dismutase (MnSOD) as well as the level of serum lipid profile in the BDL fibrotic rat model...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238463/protective-effect-of-metformin-on-toxicity-of-butyric-acid-and-arsenic-in-isolated-liver-mitochondria-and-langerhans-islets-in-male-mice-an-in-vitro-study
#14
Akram Ahangarpour, Leila Zeidooni, Mohsen Rezaei, Soheila Alboghobeish, Azin Samimi, Ali Akbar Oroojan
Objectives: Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitochondria were isolated by adopting different centrifugation methods and pancreatic islets isolated by a collagenase method...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238462/mechanisms-of-spinal-cord-injury-regeneration-in-zebrafish-a-systematic-review
#15
REVIEW
Zeynab Noorimotlagh, Mahla Babaie, Mahdi Safdarian, Tahereh Ghadiri, Vafa Rahimi-Movaghar
Objectives: To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L1.1, L1.2, Major vault protein (MVP), contactin-2 and High mobility group box1 (HMGB1) had positive promoting effects on axonal re-growth while Ptena had an inhibitory effect...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29299207/first-report-of-oxa-143-lactamase-producing-acinetobacter-baumannii-in-qom-iran
#16
Zohreh Sarikhani, Razieh Nazari, Mahmoud Nateghi Rostami
Objectives: Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Materials and Methods: For this study, 108 non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29299206/therapeutic-potential-of-juglans-regia-l-leaf-extract-against-diabetic-retinopathy-in-rat
#17
Davood Nasiry, Ali Reza Khalatbary, Hassan Ahmadvand
Objectives: Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy. Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and antioxidant status...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29299205/the-correlation-of-anandamide-with-gonadotrophin-and-sex-steroid-hormones-during-the-menstrual-cycle
#18
Na Cui, Luning Wang, Wei Wang, Jie Zhang, Yueming Xu, Lei Jiang, Guimin Hao
Objectives: The purpose of this study was to investigate the change in plasma anandamide (AEA) levels throughout the normal menstrual cycle, and to analyze the relationship among AEA, sex steroids and gonadotrophins. Materials and Methods: The patients were fertile women with normal menstrual cycle, proposed to get in vitro fertilization (IVF) treatment due to oviduct obstruction or male infertility. Patients were divided into two groups, cross-sectional (n=79) and longitudinal (n=10)...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29299204/downregulation-of-microrna-125a-is-involved-in-intervertebral-disc-degeneration-by-targeting-pro-apoptotic-bcl-2-antagonist-killer-1
#19
Ping Liu, Feng Chang, Ting Zhang, Gang Gao, Chen Yu, Sheng-Qiang Ding, Gen-Le Zuo, Xin-Hu Huang
Objectives: To investigate the role of the microRNA-125a (miR-125a) and BAK1 in intervertebral disc degeneration (IDD). Materials and Methods: Degenerative lumbar nucleus pulposus (NP) tissues were obtained from 193 patients who underwent resection, and normal controls consisted of normal NP tissues from 32 patients with traumatic lumbar fracture in our hospital. All patients were graded according to the Pfirrmann criteria. QRT-PCR was used to detect the expression of miR-125a and BAK1, and apoptosis of NP tissues detected by TUNEL staining...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29299203/memory-enhancement-and-protective-effects-of-crocin-against-d-galactose-aging-model-in-the-hippocampus-of-wistar-rats
#20
Somaye Heidari, Soghra Mehri, Hossein Hosseinzadeh
Objectives: The neurodegeneration and loss of memory function are common consequences of aging. Medicinal plants have potent protective effects against chronic neurodegenerative diseases. The aim of this study was to investigate the beneficial effects and molecular mechanisms of crocin on brain function in D-galactose (D-gal)-induced aging model in rats. Materials and Methods: Male Wistar rats weighing 220 ± 20 g were randomly divided into six groups: control, D-gal (400 mg/kg, SC), D-gal (400 mg/kg) plus crocin (7...
November 2017: Iranian Journal of Basic Medical Sciences
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