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Iranian Journal of Basic Medical Sciences

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https://www.readbyqxmd.com/read/29511502/anti-diabetic-effects-of-sargassum-oligocystum-on-streptozotocin-induced-diabetic-rat
#1
Samad Akbarzadeh, Hossein Gholampour, Parviz Farzadinia, Adel Daneshi, Bahman Ramavandi, Ali Moazzeni, Mojtaba Keshavarz, Afshar Bargahi
Objectives: Diabetes is a metabolic syndrome which is associated with the worldwide major public health problems. There are many natural compounds from the sea-market, as a valuable aquatic source, along with the variety of health and therapeutic benefits. In the present research, with respect to the traditional and ethnic uses of Sargassum oligocystum algae for healing of some diseases which have similar metabolic mechanism to the diabetes, its anti-diabetic effects in animal model was proposed...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511501/the-first-case-of-nshl-by-direct-impression-on-eya1-gene-and-identification-of-one-novel-mutation-in-myo7a-in-the-iranian-families
#2
Ehsan Razmara, Fatemeh Bitarafan, Elika Esmaeilzadeh-Gharehdaghi, Navid Almadani, Masoud Garshasbi
Objectives: Targeted next-generation sequencing (NGS) provides a consequential opportunity to elucidate genetic factors in known diseases, particularly in profoundly heterogeneous disorders such as non-syndromic hearing loss (NSHL). Hearing impairments could be classified into syndromic and non-syndromic types. This study intended to assess the significance of mutations in these genes to the autosomal recessive/dominant non-syndromic genetic load among Iranian families. Materials and Methods: Two families were involved in this research and two patients were examined by targeted next-generation sequencing...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511500/-bax-bcl-2-expression-ratio-in-prediction-of-response-to-breast-cancer-radiotherapy
#3
Hosein Azimian, Mahdieh Dayyani, Mohammad Taghi Bahreyni Toossi, Mahmoud Mahmoudi
Objectives: Radiotherapy is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is essential to implement an individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis pathway on radiosensitivity and normal tissue complications caused by the radiotherapy. Materials and Methods: Peripheral blood mononuclear cells from ten breast cancer patients were exposed to 6MV X-rays to deliver 1 and 2 Gy...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511499/mir-103-regulates-the-angiogenesis-of-ischemic-stroke-rats-by-targeting-vascular-endothelial-growth-factor-vegf
#4
Fu-Ping Shi, Xue-Hong Wang, Hong-Xin Zhang, Meng-Meng Shang, Xiao-Xi Liu, Hai-Min Sun, Yue-Ping Song
Objectives: To investigate the effect of miR-103 on the angiogenesis of ischemic stroke rats via targeting vascular endothelial growth factor (VEGF) at the molecular level. Materials and Methods: Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. FITC-dextran, matrigel, and Trans-well assays were used to evaluate the vascular density, tube formation, and cell migration respectively...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511498/the-inhibitory-effects-of-20-r-ginsenoside-rg3-on-the-proliferation-angiogenesis-and-collagen-synthesis-of-hypertrophic-scar-derived-fibroblasts-in-vitro
#5
Mengyao Tang, Wenbo Wang, Liying Cheng, Rong Jin, Lu Zhang, Weiwei Bian, Yuguang Zhang
Objectives: Therapeutic effect of many selectable methods applied in clinical practice for treating hypertrophic scar (HS) is not still so satisfactory. Meanwhile, a few medicines may lead to several undesirable complications. The traditional Chinese medicine, Rg3 , has been reported for multiple antitumor effects previously. We have conducted series of animal experiments and confirmed the inhibitory effect of Rg3 in HS before. The aim of this study was to further verify the conclusions of previous studies and reveal the specific functional mechanisms of Rg3 ...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511497/role-of-melatonin-receptors-in-the-effect-of-estrogen-on-brain-edema-intracranial-pressure-and-expression-of-aquaporin-4-after-traumatic-brain-injury
#6
Nader Shahrokhi, Mohammad Khaksari, Gholamreza AsadiKaram, Zahra Soltani, Nava Shahrokhi
Objectives: Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries. This study examined the role of melatonin receptors in the neuroprotective effects of estrogen. Materials and Methods: Seventy female ovariectomized Wistar rats were divided into five groups and two subgroups. All animals underwent brain trauma. The groups were as follow: 1) trauma, 2) melatonin receptor antagonist vehicle + estrogen, 3) MT1 melatonin receptor antagonist + estrogen, 4) MT2 melatonin receptor antagonist+ estrogen, 5) MT3 melatonin receptor antagonist+ estrogen...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511496/mir-103-alleviates-autophagy-and-apoptosis-by-regulating-sox2-in-lps-injured-pc12-cells-and-sci-rats
#7
Guowei Li, Tao Chen, Yingxian Zhu, Xiaoyu Xiao, Juyuan Bu, Zongwen Huang
Objectives: Recent studies revealed that microRNAs (miRNAs) may play crucial roles in the responses and pathologic processes of spinal cord injury (SCI). This study aimed to investigate the effect and the molecular basis of miR-103 on LPS-induced injuries in PC12 cells in vitro and SCI rats in vivo . Materials and Methods: PC12 cells were exposed to LPS to induce cell injuries to mimic the in vitro model of SCI. The expression of miR-103 and SOX2 in PC12 cells were altered by transient transfections...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511495/immunogenicity-of-enterotoxigenic-escherichia-coli-outer-membrane-vesicles-encapsulated-in-chitosan-nanoparticles
#8
Nafiseh Noroozi, Seyed Latif Mousavi Gargari, Shahram Nazarian, Samaneh Sarvary, Razieh Rezaei Adriani
Objectives: Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrheal disease in humans, particularly in children under 5 years and travelers in developing countries.To our knowledge, no vaccine is licensed yet to protect against ETEC infection. Like many Gram-negative pathogens, ETEC can secrete outer membrane vesicles (OMVs). These structures contain various immunogenic virulence proteins such as LT and therefore can be used as vaccine candidates. In this study we attempted to isolate the OMVs of ETEC cultivated at different temperatures and evaluate their immunogenicity and protective efficacy in a murine model of infection...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511494/mir-9-5p-and-mir-106a-5p-dysregulated-in-cd4-t-cells-of-multiple-sclerosis-patients-and-targeted-essential-factors-of-t-helper17-regulatory-t-cells-differentiation
#9
Maryam Majd, Aref Hosseini, Kamran Ghaedi, Abbas Kiani-Esfahani, Somayeh Tanhaei, Hanieh Shiralian-Esfahani, Seyed Yahya Rahnamaee, Seyed Javad Mowla, Mohammad Hossein Nasr-Esfahani
Objectives: Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS. Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. Thereby, as a step closer, we analyzed the expression profile of miR-9-5p and miR-106a-5p, and protein level of retinoic acid receptor (RAR)-related orphan receptor C ( RORC ; Th17 master transcription factor) as direct target of miR-106a-5p and forkhead box P3 ( FOXP3 ; Treg master transcription factor) as indirect target of miR-9-5p in CD4+ T cells in two groups of relapsing and remitting in our relapsing-remitting MS (RR-MS) patients...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511493/protective-effect-of-scutellarin-on-myocardial-infarction-induced-by-isoprenaline-in-rats
#10
Haibo Huang, Qianqian Geng, Hong Yao, Zhenhuang Shen, Zhenhong Wu, Xiaoqing Miao, Peiying Shi
Objectives: Scutellarin ( Scu ) is the main effective constituent of Erigeron breviscapus which has anti-oxidant, anti-apoptotic, anti-inflammatory and other therapeutic properties. The purpose of this study was to investigate the protective effect of Scu on myocardial infarction (MI) induced by isoprenaline (ISO). Materials and Methods: The rats were subcutaneously injected with ISO (45 mg/kg) on the first day, then single tail-intravenously injected with different doses of Scu (10 mg/kg, 20 mg/kg, 40 mg/kg) for 7 consecutive days...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511492/design-of-a-humanized-anti-vascular-endothelial-growth-factor-nanobody-and-evaluation-of-its-in-vitro-function
#11
Fatemeh Kazemi-Lomedasht, Serge Muyldermans, Mahdi Habibi-Anbouhi, Mahdi Behdani
Objectives: Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities. Their minimal size assists in reaching otherwise largely inaccessible regions of antigens. However, their camelid origin raises a possible concern of immunogenicity when used for human therapy. Humanization is a promising approach to overcome the problem. Materials and Methods: Here, we designed a humanized version of previously developed nanobody (anti vascular endothelial growth factor nanobody), evaluated and compared its predicted 3D structure, affinity and biological activity with its original wild type nanobody...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511491/the-cucurbitacins-d-e-and-i-from-ecballium-elaterium-l-upregulate-the-lc3-gene-and-induce-cell-cycle-arrest-in-human-gastric-cancer-cell-line-ags
#12
Naser Jafargholizadeh, Seyed Jalal Zargar, Younes Aftabi
Objectives: Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A. Rich fruits on some apoptotic and autophagy genes in human gastric cancer cell line AGS. Materials and Methods: Using quantitative reverse transcription PCR (qRT-PCR), the expression of LC3 , VEGF , BAX , caspase-3 , and c-MYC genes were quantified in AGS cells 24 hr after treatment with cucurbitacins D, E, and I at concentrations 0...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511490/chronic-intermittent-hypobaric-hypoxia-attenuates-monocrotaline-induced-pulmonary-arterial-hypertension-via-modulating-inflammation-and-suppressing-nf-%C3%AE%C2%BAb-p38-pathway
#13
Lei Gao, Jun Liu, Yongmei Hao, Zengren Zhao, Huilian Tan, Jie Zhang, Ning Meng, Qinghou Zheng, Zhen Wang, Yi Zhang
Objectives: Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the effect of chronic intermittent hypobaric hypoxia (CIHH) on pulmonary inflammation and remodeling in monocrotaline (MCT) induced PAH in rats. Materials and Methods: An in vivo model of PAH induced by MCT was employed...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511489/the-effect-of-bone-marrow-mesenchymal-stem-cells-on-recovery-of-skeletal-muscle-after-neurotization-surgery-in-rat
#14
Gholam Hossein Farjah, Farzaneh Fazli, Mojtaba Karimipour, Bagher Pourheidar, Behnam Heshmatiyan, Maryam Pourheidar
Objectives: When the nerve is injured near its entrance to the muscle belly, we cannot perform conventional methods. One useful method in such a situation is neurotization surgery. In this study, Bone marrow mesenchymal stem cells (BMSCs) implanted into the paralyzed muscle after neurotization surgery. These cells can stimulate axon growth and motor endplate formation, also prevent muscle atrophy. Materials and Methods: Thirty-six adult male Sprague-Dawley rats were randomized into six groups: intact group, sham surgery group, control group, DMEM group, cell+DMEM group, denervated group...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29511488/amelioration-of-carbon-tetrachloride-induced-hepatic-injury-by-emulsified-antrodia-extract
#15
Wei-Chih Chang, Chang-Tsen Hung, Yuh-Shuen Chen, Chih-Chi Hsueh, Chien-Wei Hou, Horng-Liang Lay
Objectives: Antrodia cinnamomea (AC) is found with anti-inflammatory and immunomodulatory biological activities. In this study, we investigated the anti-hepatitis effect of the emulsified AC extract from RO water or supercritical fluid CO2 with ethanol co-solvent extract methods of AC preparations. Materials and Methods: Five groups of eight to ten weeks male rats with a count of ten for each group were studied to evaluate the protection of two kinds of AC extract from hepatic injury...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456821/resveratrol-decreases-apoptosis-and-nlrp3-complex-expressions-in-experimental-varicocele-rat-model
#16
Elnaz Hajipour, Farideh Jalali Mashayekhi, Ghasem Mosayebi, Maryam Baazm, Adib Zendedel
Objectives: Varicocele is an abnormal dilation in the testicular vein, which can cause hypoxia, reactive oxygen species accumulation, elevation in testicular temperature, and promote apoptosis and increase proinflammatory cytokine production. According to the varicocele pathophysiology, it is possible that a group of cytosolic receptors called nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes also involve in varicocele pathogenesis...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456820/immunogenicity-of-heparin-binding-hemagglutinin-expressed-by-pichia-pastoris-gs115-strain
#17
Xindong Teng, Xiaoguang Chen, Ke Zhu, Hefei Xu
Objectives: Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis ( M. tuberculosis ) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins for the purpose of diagnosing M. tuberculosis infection or for the immunization. Here, HBHA was expressed by Pichia pastoris ( P. pastoris ) GS115 strain , and the immunogenicity of HBHA was evaluated...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456819/comparison-of-the-efficacy-of-piascledine-and-transforming-growth-factor-%C3%AE-1-on-chondrogenic-differentiation-of-human-adipose-derived-stem-cells-in-fibrin-and-fibrin-alginate-scaffolds
#18
Batool Hashemibeni, Ali Valiani, Mojtaba Esmaeli, Mohammad Kazemi, Maryam Aliakbari, Farhad Golshan Iranpour
Objectives: The aim of this study was to compare the chondrogenic induction potential of Piascledine and TGF-β1 on adipose-derived stem cells (ADSCs) in fibrin and fibrin-alginate scaffolds. Materials and Methods: Human subcutaneous adipose tissues were harvested from three patients who were scheduled to undergo liposuction. Isolated ADSCs were proliferated in a culture medium. Then, the cells were seeded in fibrin or fibrin-alginate scaffolds and cultured for 14 days in a chondrogenic medium containing Piascledine, TGF-β1, or both...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456818/synthesis-and-antiplasmodial-activity-of-novel-phenanthroline-derivatives-an-in-vivo-study
#19
Azar Tahghighi, Safoura Karimi, Arezoo Rafie Parhizgar, Sedigheh Zakeri
Objectives: Due to the rapid increased drug resistance to Plasmodium parasites, an urgent need to achieve new antiplasmodial drugs is felt. Therefore, in this study, the new synthetic phenanthroline derivatives were synthesized with antiplasmodial activity. Materials and Methods: A series of 1,10-phenanthroline derivatives containing amino-alcohol and amino-ether substituents were synthesized via facile procedures, starting with 5,6-epoxy-1,10-phenanthroline. Their antiplasmodial activity was then evaluated using Peter's 4-day suppressive test against Plasmodium berghei-infected mice (ANKA strain)...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456817/s100a9-aggravates-bleomycin-induced-dermal-fibrosis-in-mice-via-activation-of-erk1-2-mapk-and-nf-%C3%AE%C2%BAb-pathways
#20
Xue Xu, Zhiyong Chen, Xiaoxia Zhu, Dandan Wang, Jun Liang, Cheng Zhao, Xuebing Feng, Jiucun Wang, Hejian Zou, Lingyun Sun
Objectives: This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of scleroderma. Materials and Methods: The content of S100A9 in the skin tissues of mice with scleroderma was determined. Different concentrations of bleomycin (BLM) and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes in the skin of these mice were monitored. Specifically, the levels of inflammatory cytokines and alpha smooth muscle actin (α-SMA), the activation of extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways, and the expression of the receptor for advanced glycation end-product (RAGE) in the skin were determined...
February 2018: Iranian Journal of Basic Medical Sciences
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