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Iranian Journal of Basic Medical Sciences

Gholamali Jelodar, Sajjad Masoomi, Farhad Rahmanifar
Objectives: Herbal medicines are an alternative choice for treatment or controlling of polycystic ovary syndrome (PCOS). Effect of hydroalcoholic extract of flaxseed was evaluated on ovarian hormones and histological changes of uterus and ovary in a PCOS-induced rat model. Materials and Methods: Twenty four rats divided into four groups including negative control, positive control, PCOS and treatment groups. Positive control group received hydroalcoholic extract of flaxseed for 30 days...
June 2018: Iranian Journal of Basic Medical Sciences
Fahimeh Mohammadghasemi, Sina Khajeh Jahromi
Objectives: Nicotine as a toxic substance leads to impairment of the reproductive system function. The aim of this study was to evaluate effects of melatonin on testicular alterations, sperm nuclear integrity, and epididymal sperm parameters in mice treated with nicotine. Materials and Methods: Male mice were divided into four groups. Group A received the vehicle, group B received nicotine 0.1 mg/100 g BW, group C received melatonin 10 mg/kg, group D received nicotine plus melatonin...
June 2018: Iranian Journal of Basic Medical Sciences
Zhigang Liu, Shuwei Huang, Pengfei Hu, Hui Zhou
Objectives: To investigate the role of autophagy in advanced glycation end products (AGEs)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs). Materials and Methods: After culture, VSMCs were treated with 0, 1, 10, and 100 μg/ml concentrations of AGEs. Autophagy specific protein light chain 3 (LC3)-I/II was determined by western blotting, autophagosomes were observed with electron microscopy, cell proliferation was quantified using the methyl thiazolyl tetrazolium (MTT) assay, and cell migration was evaluated using Transwell migration and scratch assays...
June 2018: Iranian Journal of Basic Medical Sciences
Siavash Parvardeh, Masoumeh Sabetkasaei, Mahsa Moghimi, Alireza Masoudi, Shiva Ghafghazi, Fatemeh Mahboobifard
Objectives: Growing evidence demonstrates that L-arginine/NO/cGMP/KATP channel pathway has a modulatory role in pain perception. Previous studies have shown that thymoquinone exerts antinociceptive effects; however, the mechanisms underlying antinociception induced by thymoquinone have not been fully clarified. The aim of the present study was to evaluate the role of L-arginine/NO/cGMP/KATP channel pathway in the central and peripheral antinociceptive effect of thymoquinone in rats. Materials and Methods: Rats were pretreated intraplantarly (IPL) or intracerebroventricularly (ICV) with L-arginine (the NO precursor), l-NAME (an NO synthase inhibitor), SNAP (an NO donor), methylene blue (a guanylyl cyclase inhibitor), glibenclamide (the blocker of KATP channel), and tetraethylammonium (TEA, a Kv channel blocker) before the injection of thymoquinone...
June 2018: Iranian Journal of Basic Medical Sciences
Hao Fu, Wenke Song, Yufei Wang, Wenyi Deng, Tingting Tang, Wenjing Fan, Shunlin Qu
Objectives: The stress-responsive genes of Sestrin family are recognized as new tumor suppressor genes in breast carcinoma, however, the function of Sestrin family in human prostate cancer is not clear. Ionizing radiation (IR) is known to induce Sestrin gene expression in breast cancer cells. However, the response of Sestrin to IR has not been reported in PC3 prostate cancer cells. Materials and Methods: Sestrin2 expression in prostate cancer cell lines (PC3, LNCaP clone FGC, and DU145) was detected by Western blot and real-time PCR...
June 2018: Iranian Journal of Basic Medical Sciences
Mohammad Khaksari, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Zahra Soltani, Sina Motamedi, Fatemeh Moramdi, Masoud Islami, Shahriyar Shafa, Sepehr Khosravi
Objectives: Neuroprotection is created following the inhibition of angiotensin II type 1 receptor (AT1R). Therefore, the purpose of this research was examining AT1R blockage by candesartan in diffuse traumatic brain injury (TBI). Materials and Methods: Male rats were assigned into sham, TBI, vehicle, and candesartan groups. Candesartan (0.3 mg/kg) or vehicle was administered IP, 30 min post-TBI. Brain water and Evans blue contents were determined, 24 and 5 hr after TBI, respectively...
June 2018: Iranian Journal of Basic Medical Sciences
Shokooh Karimi, Seyed Jalal Hosseinimehr, Hamid Reza Mohammadi, Ali Reza Khalatbary, Fereshteh Talebpour Amiri
Objectives: Cisplatin (CP), as an anti-neoplastic drug, causes testicular damage. Zataria multiflora Boiss (ZM), a medicinal plant, has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of ZM against CP-induced testicular toxicity. Materials and Methods: In this experimental study, thirty-two adult male mice were randomly divided into four groups. The control group received normal saline with oral gavage during 7 days; ZM group received ZM (200 mg/kg) during 7 days by gavage; CP group received CP (10 mg/kg) intraperitoneally (IP) in the 5th day of study; ZM + CP group received ZM during 7 days and CP was injected in 5th day...
June 2018: Iranian Journal of Basic Medical Sciences
Firouzeh Gholampour, Leila Khangah, Jafar Vatanparast, Hamid Reza Karbalaei-Heidari, Seyed Mohammad Owji, Aminollah Bahaoddini
Objectives: We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and Methods: I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was performed using four cycles of 2 min occlusions of the left femoral artery and 3 min reperfusion at the beginning of renal ischemia. The animals were given normal saline (vehicle), NG-nitro-L-arginine methyl ester (L-NAME) or L-arginine...
June 2018: Iranian Journal of Basic Medical Sciences
Vehbi Yavuz Tokgoz, Mehmet Sipahi, Ozlem Keskin, Gulname Findik Guvendi, Selcuk Takir
Objectives: The aim of the present study is to investigate probable acute effects of vitamin D on ischemia-reperfusion injury in the rat ovary. Materials and Methods: A group of 30 Wistar albino rats was divided into five groups of 6 each. Group 1: underwent laparotomy only and the ovaries were removed. Group 2: 3-hr ischemia followed by excision of the ovaries. Group 3: 3-hr ischemia and 3-hr reperfusion and the ovaries were removed. Group 4: vitamin D was administered 30 min prior to the 3-hr of ischemia and the ovaries were excised at the end of ischemia period...
June 2018: Iranian Journal of Basic Medical Sciences
Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Maryam Sadat Daneshpour, Hamid Zand, Parvin Mirmiran, Fereidoun Azizi
Objectives: There are controversial results regarding the effect of the interaction of CETP polymorphisms with dietary fats on the lipid profiles. The aim of this study was to examine the effect of CETP polymorphisms (rs5882 and rs3764261) and macronutrient intakes interaction in relation to metabolic syndrome (MetS) or its components. Materials and Methods: In this nested case-control study, subjects were selected from among participants of the Tehran Lipid and Glucose Study...
June 2018: Iranian Journal of Basic Medical Sciences
Siamak Asri-Rezaei, Alireza Nourian, Ali Shalizar-Jalali, Gholamreza Najafi, Ali Nazarizadeh, Mobin Koohestani, Ali Karimi
Objectives: The current study was conducted to examine the possible protective and retentive effects of one-week intra-peritoneal (IP) administration of selenium nanoparticles (Se-NPs), compared to its bulk counterpart, selenite sodium (Ss), after one complete cycle of spermatogenesis in mature male mice. Materials and Methods: Thirty adult male mice were divided into 3 groups. Control group was administrated phosphate-buffered saline (IP) and the other groups received Ss (0...
June 2018: Iranian Journal of Basic Medical Sciences
Ravi Chandra Sekhara Reddy Danduga, Dondapati Subba Reddy, Singapalli Meenakshi Seshadri, Kavati Sanith Satya Has, Kola Phani Kumar
Objectives: The study was intended to investigate the combined influence of two neuroprotective agents pramipexole and n-acetylcysteine on global cerebral ischemic reperfusion injury (GCIRI) model in rats. Materials and Methods: GCIRI was induced by bilateral common carotid artery ligation (BCCA) in rats. Animals were divided into six groups. Groups I, II, and III received saline intraperitoneally (IP) (5 ml/kg/day, 0.9 % saline). The remaining groups IV, V, and VI were treated with n-acetylcysteine (NAC-150 mg/kg/day, IP), pramipexole (PPX-0...
June 2018: Iranian Journal of Basic Medical Sciences
Zahra Rezaieyazdi, Morteza Kochakzadeh, Mohammad Reza Hatef, Habibollah Esmaily, Abdolreza Malek, Narges Valizadeh, Samira Tabaei, Houshang Rafatpanah
Objectives: Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases in children. The complex nature of this immune-mediated disease owes itself to several predisposing genes and environmental factors affecting its pathogenesis. Conducted in Iran, this study was originally intended to investigate every possible association between HLA DRB1 alleles and a susceptibility to JIA. Materials and Methods: In this case-control study, 45 patients with a definite diagnosis of JIA based on International League against Rheumatism (ILAR) criteria were compared against 46 healthy controls...
June 2018: Iranian Journal of Basic Medical Sciences
Alireza Raji-Amirhasani, Siyavash Joukar, Vida Naderi-Boldaji, Mohammad-Abbas Bejeshk
Objectives: Considering the lack of information, the effects of mild endurance exercise plus blood flow restriction (BFR) on electrocardiographic parameters, hypertrophy index, and expression of angiotensin II receptors type 1 (AT1R) and type 2 (AT2R) and apelin receptor (APJ) were assessed in hearts of old male rats. Materials and Methods: Animal were grouped as control (CTL), Sham (Sh), lower extremities blood flow restriction (BFR), exercise (Ex), Sham + exercise (Sh + Ex), and blood flow restriction + exercise (BFR + Ex)...
June 2018: Iranian Journal of Basic Medical Sciences
Zahra Hassannejad, Shayan Abdollah Zadegan, Aida Shakouri-Motlagh, Mona Mokhatab, Motahareh Rezvan, Mahdi Sharif-Alhoseini, Farhad Shokraneh, Pouria Moshayedi, Vafa Rahimi-Movaghar
Objectives: To reach an evidence-based knowledge in the context of the temporal-spatial pattern of neuronal death and find appropriate time of intervention in order to preserve spared neurons and promote regeneration after traumatic spinal cord injury (TSCI). Materials and Methods: The study design was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided systematic review. PubMed and EMBASE were searched (24 October, 2015) with no temporal or linguistic restrictions...
June 2018: Iranian Journal of Basic Medical Sciences
Sara Shokooh Saremi, Maryam Shahryari, Razieh Ghoorchian, Hamed Eshaghian, Seyed Amir Jalali, Amin Reza Nikpoor, Mahmoud Reza Jafari, Ali Badiee
Objectives: Dendritic cells (DCs) play a critical role in activation of T cell responses. Induction of type1 T helper (Th1 ) immune response is essential to generate protective immunity against cutaneous leishmaniasis. The intrinsic tendency of liposomes to have interaction with antigen-presenting cells is the main rationale to utilize liposomes as antigen carriers. In the present study, the effect of lipid phase transition temperature on DCs maturation and liposome uptake by murine bone marrow derived dendritic cells and human monocyte derived dendritic cells was investigated...
May 2018: Iranian Journal of Basic Medical Sciences
Zhongmeng Yang, Yuxing Tang, Qing Zhao, Huading Lu, Guoyong Xu
Objectives: Osteoarthritis (OA), characterized by degradation of articular cartilage, is a leading cause of disability. As the only cell type present in cartilage, chondrocytes play curial roles in the progression of OA. In our study, we aimed to explore the roles of miR-23b in the lipopolysaccharide (LPS)-induced inflammatory injury. Materials and Methods: LPS-induced cell injury of ATDC5 cells was evaluated by the loss of cell viability, enhancement of cell apoptosis, alteration of apoptosis-associated proteins, and release of inflammatory cytokines...
May 2018: Iranian Journal of Basic Medical Sciences
Elia Saragard Kermani, Zahra Nazari, Mehdi Mehdizadeh, Majid Shahbazi, Mohammad Jafar Golalipour
Objectives: Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats. Materials and Methods: Diabetes was induced in 40 adult Wistar rats by intraperitoneal injection of 45 mg/kg of streptozotocin...
May 2018: Iranian Journal of Basic Medical Sciences
Emad Kordbacheh, Shahram Nazarian, Davoud Sadeghi, Abbas Hajizadeh
Objectives: Enterotoxigenic Escherichia coli (ETEC) is known as the most common bacterial causes of diarrheal diseases related to morbidity and mortality. Heat-labile enterotoxin (LT) is a part of major virulence factors in ETEC pathogenesis. Antigen entrapment into nanoparticles (NPs) can protect them and enhance their immunogenicity. Materials and Methods: In the present study, recombinant LTB protein was expressed in E. coli BL21 (DE3) and purified by an Ni-NTA agarose column...
May 2018: Iranian Journal of Basic Medical Sciences
Abdolreza Hassanzade, Ali Mandegary, Elham Sharif, Rokhsana Rasooli, Reza Mohammadnejad, Yaser Masoumi-Ardekani
Objectives: Combination chemotherapy is a rational strategy to increase patient response and tolerability and to decrease adverse effects and drug resistance. Recently, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been reported to be associated with reduction in occurrence of a variety of cancers including lung cancer. On the other hand, growing evidences suggest that deuterium-enriched water (DEW, D2O) and deuterium-depleted water (DDW) play a role both in treatment and prevention of cancers...
May 2018: Iranian Journal of Basic Medical Sciences
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