journal
MENU ▼
Read by QxMD icon Read
search

Iranian Journal of Basic Medical Sciences

journal
https://www.readbyqxmd.com/read/28133531/in-vitro-assesment-of-anti-inflammatory-activities-of-coumarin-and-indonesian-cassia-extract-in-raw264-7-murine-macrophage-cell-line
#1
Ni Made Dwi Sandhiutami, Moordiani Moordiani, Dian Ratih Laksmitawati, Nurul Fauziah, Maesaroh Maesaroh, Wahyu Widowati
OBJECTIVES: Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer's and various cancer. Indonesian cassia (Cinnamomum burmannil C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine especially as an anti-inflammatory. This study was conducted to determine the anti-inflammatory properties of coumarin and Indonesian cassia extract (ICE) in LPS-induced RAW264...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133530/endurance-training-induces-fiber-type-specific-revascularization-in-hindlimb-skeletal-muscles-of-rats-with-chronic-heart-failure
#2
Kamal Ranjbar, Malihe Ardakanizade, Farzad Nazem
OBJECTIVES: Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS: Four weeks after surgeries (left anterior descending (LAD) artery occlusion), chronic heart failure rats were divided into 3 groups: Sham (Sham, n=10); Sedentary (Sed, n=10); Exercise training (Ex, n=10)...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133529/cisplatin-cytotoxicity-is-dependent-on-mitochondrial-respiration-in-saccharomyces-cerevisiae
#3
Santhi Priya Inapurapu, Karunakar Rao Kudle, Sreedhar Bodiga, Vijaya Lakshmi Bodiga
OBJECTIVES: To understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial DNA depleted Rho0 yeast cells. MATERIALS AND METHODS: Wild type and Rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, pH changes in cytosol/mitochondrial compartments, reactive oxygen species production and respiratory control ratio...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133528/effects-of-ellagic-acid-pretreatment-on-renal-functions-disturbances-induced-by-global-cerebral-ischemic-reperfusion-in-rat
#4
Khojasteh Hoseiny Nejad, Mohammad Kazem Gharib-Naseri, Alireza Sarkaki, Mahin Dianat, Mohammad Badavi, Yaghoub Farbood
OBJECTIVES: Global cerebral ischemia-reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of ellagic acid (EA) on certain renal disfunction after GCIR. MATERIALS AND METHODS: Adult male Wistar rats (n=32, 250-300 g) were used. GCIR was induced by bilateral vertebral and common carotid arteries occlusion (4-VO). Animal groups were: 1) received DMSO/saline (10%) as solvent of EA, 2) solvent + GCIR, 3) EA + GCIR, and 4) EA...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133527/time-course-of-neuroprotection-induced-by-in-vivo-normobaric-hyperoxia-preconditioning-and-angiogenesis-factors
#5
Meisam Shahhoseini, Mohammad Reza Bigdeli
OBJECTIVES: Every year, a large number of people lose their lives due to stroke. Stroke is the second leading cause of death worldwide. Surprisingly, recent studies have shown that preconditioning with hyperoxia (HO) increases tissue tolerance to ischemia, ultimately reducing damages caused by stroke. Addressed in this study are beneficial contributions from HO preconditioning into reduced harm to be incurred by the attack, as well as its effect on the expression levels of vascular endothelial growth factor (VEGF) and endostatin...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133526/2-2-4-benzoylpiperazin-1-yl-ethyl-isoindoline-1-3-dione-derivatives-synthesis-docking-and-acetylcholinesterase-inhibitory-evaluation-as-anti-alzheimer-agents
#6
Ahmad Mohammadi-Farani, Nasibeh Abdi, Alireza Moradi, Alireza Aliabadi
OBJECTIVES: Alzheimer's disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of new donepezil like analogs. MATERIALS AND METHODS: A new series of phthalimide derivatives (compounds 4a-4j) were synthesized via Gabriel protocol and subsequently amidation reaction was performed using various benzoic acid derivatives...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133525/antioxidant-and-antiapoptotic-effects-of-erdosteine-in-a-rat-model-of-ovarian-ischemia-reperfusion-injury
#7
Vedat Ugurel, Ahmet Cagatay Cicek, Mustafa Cemek, Selim Demirtas, A Tuba Kocaman, Turan Karaca
OBJECTIVES: To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion-detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. MATERIALS AND METHODS: Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven days before the induction of torsion/retorsion, (10 mg/kg/days). The IR and IR-E groups were exposed to right unilateral adnexal torsion for 3 hr...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133524/comparison-of-activated-charcoal-and-sodium-polystyrene-sulfonate-resin-efficiency-on-reduction-of-amitriptyline-oral-absorption-in-rat-as-treatments-for-overdose-and-toxicities
#8
Gholamhossein Yousefi, Mohammad Bizhani, Akram Jamshidzadeh, Saeid Gholamzadeh
OBJECTIVES: Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. MATERIALS AND METHODS: Sprague-Dawley male rats were divided into six groups. Group I: control, group II: AMT 200 mg/kg as single dose orally, group III and IV: AC 1g/kg as single dose orally 5 and 30 min after AMT administration respectively, and group 5 and 6: SPS 1 g/kg as single dose orally 5 and 30 min after AMT administration, respectively...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133523/the-cytotoxic-effect-of-memantine-and-its-effect-on-cytoskeletal-proteins-expression-in-metastatic-breast-cancer-cell-line
#9
Sima Seifabadi, Golnaz Vaseghi, Shaghayegh Haghjooy Javanmard, Elham Omidi, Mohammadhasan Tajadini, Bahareh Zarrin
OBJECTIVES: Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is the potential inhibitor of tau protein in neurons. This study determines the effect of memantine on breast cancer cell migration and proliferation, tau and stathmin gene expression in cancer cells and its synergistic effect with paclitaxel...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133522/the-effect-of-ghrelin-on-kiss-1-and-kissr-gene-transcription-and-insulin-secretion-in-rat-islets-of-langerhans-and-cri-d2-cell-line
#10
Mandana Mahmoodzaeh Sagheb, Negar Azarpira, Mokhtar Mokhtary
OBJECTIVES: Ghrelin is a peptide hormone that has been shown to have numerous central and peripheral effects. The central effects including GH secretion, food intake, and energy homeostasis are partly mediated by Kiss1- KissR signaling pathway. Ghrelin and its receptor are also expressed in the pancreatic islets. Ghrelin is one of the key metabolic factors controlling insulin secretion from the islets of Langerhans. We hypothesize that the inhibitory effect of ghrelin on KiSS-1 and KissR in the islet cells may be similar to the same inhibitory effect of ghrelin in the hypothalamus...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133521/activation-of-neurotrophins-in-lumbar-dorsal-root-probably-contributes-to-neuropathic-pain-after-spinal-nerve-ligation
#11
Abdolreza Kazemi, Masoud Rahmati, Rasoul Eslami, Vahid Sheibani
OBJECTIVES: Neurotrophins (NTs) exert various effects on neuronal system. Growing evidence indicates that NTs are involved in the pathophysiology of neuropathic pain. However, the exact role of these proteins in modulating nociceptive signaling requires being defined. Thus, the aim of this study was to evaluate the effects of spinal nerve ligation (SNL) on NTs activation in the lumbar dorsal root. MATERIALS AND METHODS: Ten male Wistar rats were randomly assigned to two groups: tight ligation of the L5 spinal nerve (SNL: n=5) and Sham (n=5)...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133520/low-frequency-vibration-treatment-of-bone-marrow-stromal-cells-induces-bone-repair-in-vivo
#12
Shengwei He, Wenzhi Zhao, Lu Zhang, Lidong Mi, Guangyu Du, Chuanxiu Sun, Xuegang Sun
OBJECTIVES: To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. MATERIALS AND METHODS: Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. To test differentiation, bones were isolated and demineralized, supplemented with bone marrow stromal cells, and implanted into humerus bone defects...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133519/chronopharmacological-effects-of-growth-hormone-on-the-executive-function-and-oxidative-stress-response-in-rats
#13
Carlos K B Ferrari, Eduardo L França, Luciane A Monteiro, Bruno L Santos, Alfredo Pereira-Junior, Adenilda C Honorio-França
OBJECTIVES: To investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. MATERIALS AND METHODS: Fifty male Wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn superoxide dismutase (Cu, Zn-SOD), and superoxide release by spleen macrophages were evaluated...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133518/evaluation-of-ethylcellulose-and-its-pseudolatex-surelease-in-preparation-of-matrix-pellets-of-theophylline-using-extrusion-spheronization
#14
Hadi Afrasiabi Garekani, Roshanak Dolatabadi, Abbas Akhgari, Mohammad Reza Abbaspour, Fatemeh Sadeghi
OBJECTIVES: This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets. MATERIALS AND METHODS: The effect of addition of EC was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. Also the effect of type of granulating liquid (water or Surelease) was investigated on characteristics of selected pellets...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28133517/phytochemistry-and-pharmacology-of-ferula-persica-boiss-a-review
#15
REVIEW
Zohreh Sattar, Mehrdad Iranshahi
Ferula persica, is the well-known species of the genus Ferula in Iran and has two varieties: persica and latisecta. They have both been extensively used in traditional medicine for a wide range of ailments. A great number of chemical compounds including sesquiterpene coumarins and polysulfides have been isolated from this plant. Fresh plant materials, crude extracts and isolated components of F. persica have shown a wide spectrum of pharmacological properties including anti-pigmentation in Serratia marcescens, cytotoxic, antibacterial, anti-fungal, anti-leishmanial, cancer chemopreventive, reversal of multi-drug resistance, anti-inflammatory and lipoxygenase inhibitory activity...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096971/carthamus-tinctorius-l-ameliorates-brain-injury-followed-by-cerebral-ischemia-reperfusion-in-rats-by-antioxidative-and-anti-inflammatory-mechanisms
#16
Pin-Kuei Fu, Tai-Long Pan, Chi-Yu Yang, Kee-Ching Jeng, Nou-Ying Tang, Ching-Liang Hsieh
OBJECTIVES: Carthamus tinctorius L. (CT) or safflower is widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia-reperfusion (I/R) brain injury and elucidated the underlying mechanism. MATERIALS AND METHODS: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0.2-0.6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096970/inhibition-of-akt-phosphorylation-attenuates-resistance-to-tnf-%C3%AE-cytotoxic-effects-in-mcf-7-cells-but-not-in-their-doxorubicin-resistant-derivatives
#17
Morteza Ghandadi, Atieh Mohammadi, Javad Behravan, Khalil Abnous, Negin Haj-Ali, Melika Ehtesham Gharaee, Fatemeh Mosaffa
OBJECTIVES: Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in resistance of MCF-7 and MCF-7/Adr against TNF-α cytotoxicity. MATERIALS AND METHODS: The role of Akt activation in TNF-α cytotoxicity was investigated by MTT cell viability assay following treatment of the cells with the chemical inhibitor of Akt activation with or without TNF-α treatment...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096969/dendrosomal-nanocurcumin-and-p53-overexpression-synergistically-trigger-apoptosis-in-glioblastoma-cells
#18
Reihaneh Keshavarz, Babak Bakhshinejad, Sadegh Babashah, Narges Baghi, Majid Sadeghizadeh
OBJECTIVES: Glioblastoma is the most lethal tumor of the central nervous system. Here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (DNC), alone and in combination, on glioblastoma tumor cells. MATERIALS AND METHODS: MTT assay was exploited to measure the viability of U87-MG cells against DNC treatment. Cells were separately subjected to DNC treatment and transfected with p53-containing vector and then were co-exposed to DNC and p53 overexpression[A GA1][B2]...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096968/a-novel-atheroprotective-role-of-mf59-like-adjuvant-when-co-administered-with-cetp-vaccine-in-rabbit-model-of-atherosclerosis
#19
Tamara Aghebati, Amir Hooshang Mohammadpour, Mohammad Afshar, Mahmoud Reza Jaafari, Khalil Abnous, Saeed Nazemi, Sobhan Issazadeh, Saeed Hashemzadeh, Mohammad Zare, Ali Badiee
OBJECTIVES: In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. MATERIALS AND METHODS: Tetanus toxoid- CETP peptide (TT-CETP) was mixed with Alum/CpG or MF59-like and administered subcutaneously for total five times in rabbit model of atherosclerosis...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096967/volatile-compounds-analysis-and-antioxidant-antimicrobial-and-cytotoxic-activities-of-mindium-laevigatum
#20
Abdolrasoul Haghir Ebrahimabadi, Mohammad Mahdi Movahedpour, Hossain Batooli, Ebrahim Haghir Ebrahimabadi, Asma Mazoochi, Maryam Mobarak Qamsari
OBJECTIVES: Mindium laevigatum is an endemic plant of Iran and Turkey and is widely used as blood purifier, antiasthma and antidyspnea in traditional medicine. Chemical composition of volatile materials of the plant and its antioxidant, antimicrobial and cytotoxic activities were reported in this study. MATERIALS AND METHODS: Simultaneous distillation-extraction (SDE) and GC-Mass-FID analysis were used for the plant volatile materials chemical composition identification and quantification...
December 2016: Iranian Journal of Basic Medical Sciences
journal
journal
46943
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"