journal
MENU ▼
Read by QxMD icon Read
search

Biomolecules & Therapeutics

journal
https://www.readbyqxmd.com/read/28655072/oral-administration-of-glycine-and-leucine-dipeptides-improves-skin-hydration-and-elasticity-in-uvb-irradiated-hairless-mice
#1
Jong Il Park, Ji Eun Lee, Hyun Jun Shin, Soonran Song, Won Kyung Lee, Jae Sung Hwang
Placenta is a special organ that contains many nutrients such as growth factors, minerals, and bioactive peptides. Dipeptides of glycine and leucine are major components of porcine placenta extracts (PPE) that has been used as an alternative of human placenta extracts. In this study, we investigated whether major peptides of PPE, Glycyl-L-Leucine (Gly-Leu), L-Leucyl-Glycine (Leu-Gly), and L-Leucyl-L-Leucine (Leu-Leu), affect skin hydration and elasticity in vitro and in vivo. We found that Gly-Leu and Leu-Gly dipeptides induced the expression of transglutaminase 1 in normal human epidermal keratinocytes (NHEKs) whereas Leu-Leu dipeptides did not...
June 27, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28655071/melatonin-rescues-mesenchymal-stem-cells-from-senescence-induced-by-the-uremic-toxin-p-cresol-via-inhibiting-mtor-dependent-autophagy
#2
Seung Pil Yun, Yong-Seok Han, Jun Hee Lee, Sang Min Kim, Sang Hun Lee
p-Cresol, found at high concentrations in the serum of chronic kidney failure patients, is known to cause cell senescence and other complications in different parts of the body. p-Cresol is thought to mediate cytotoxic effects through the induction of autophagy response. However, toxic effects of p-cresol on mesenchymal stem cells have not been elucidated. Thus, we aimed to investigate whether p-cresol induces senescence of mesenchymal stem cells, and whether melatonin can ameliorate abnormal autophagy response caused by p-cresol...
June 27, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28655070/inhibitory-effect-of-carnosol-on-phthalic-anhydride-induced-atopic-dermatitis-via-inhibition-of-stat3
#3
Do Yeon Lee, Chul Ju Hwang, Ji Yeon Choi, Mi Hee Park, Min Ji Song, Ki Wan Oh, Dong Ju Son, Seung Hwa Lee, Sang Bae Han, Jin Tae Hong
Carnosol is a phenolic antioxidant present in rosemary (Rosmarinus officinalis). It is known for anti-inflammatory effects, analgesic activity and anti-cancer effects. However, no study has been dedicated yet to its effect on atopic dermatitis (AD). Here, we show that carnosol effectively inhibited LPS-induced nitric oxide (NO) generation and expression of inflammatory marker proteins (iNOS and COX-2) in RAW 264.7 cells. In addition, carnosol effectively inhibits the phosphorylation of STAT3 and DNA binding activity in RAW 264...
June 27, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28605831/age-related-changes-in-sulfur-amino-acid-metabolism-in-male-c57bl-6-mice
#4
Jang Su Jeon, Jeong-Ja Oh, Hui Chan Kwak, Hwi-Yeol Yun, Hyoung Chin Kim, Young-Mi Kim, Soo Jin Oh, Sang Kyum Kim
Alterations in sulfur amino acid metabolism are associated with an increased risk of a number of common late-life diseases, which raises the possibility that metabolism of sulfur amino acids may change with age. The present study was conducted to understand the age-related changes in hepatic metabolism of sulfur amino acids in 2-, 6-, 18- and 30-month-old male C57BL/6 mice. For this purpose, metabolite profiling of sulfur amino acids from methionine to taurine or glutathione (GSH) was performed. The levels of sulfur amino acids and their metabolites were not significantly different among 2-, 6- and 18-month-old mice, except for plasma GSH and hepatic homocysteine...
June 14, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28605830/sustained-intracellular-acidosis-triggers-the-na-h-exchager-1-activation-in-glutamate-excitotoxicity
#5
Bo Kyung Lee, Yi-Sook Jung
The Na(+)/H(+) exchanger-1 (NHE-1) is a ubiquitously expressed pH-regulatory membrane protein that functions in the brain, heart, and other organs. It is increased by intracellular acidosis through the interaction of intracellular H(+) with an allosteric modifier site in the transport domain. In the previous study, we reported that glutamate-induced NHE-1 phosphorylation mediated by activation of protein kinase C-β (PKC-β) in cultured neuron cells via extracellular signal-regulated kinases (ERK)/p90 ribosomal s6 kinases (p90RSK) pathway results in NHE-1 activation...
June 14, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28605829/application-of-metabolomics-to-quality-control-of-natural-product-derived-medicines
#6
REVIEW
Kyung-Min Lee, Jun-Yeong Jeon, Byeong-Ju Lee, Hwanhui Lee, Hyung-Kyoon Choi
Metabolomics has been used as a powerful tool for the analysis and quality assessment of the natural product (NP)-derived medicines. It is increasingly being used in the quality control and standardization of NP-derived medicines because they are composed of hundreds of natural compounds. The most common techniques that are used in metabolomics consist of NMR, GC-MS, and LC-MS in combination with multivariate statistical analyses including principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA)...
June 14, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28554200/the-memory-enhancing-effects-of-liquiritigenin-by-activation-of-nmda-receptors-and-the-creb-signaling-pathway-in-mice
#7
Yong-Hyun Ko, Seung-Hwan Kwon, Ji-Young Hwang, Kyung-In Kim, Jee-Yeon Seo, Thi-Lien Nguyen, Seok-Yong Lee, Hyoung-Chun Kim, Choon-Gon Jang
Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification. However, the effects of LQ on cognitive function have not been fully explored. In this study, we evaluated the memory-enhancing effects of LQ and the underlying mechanisms with a focus on the N-methyl-D-aspartic acid receptor (NMDAR) in mice. Learning and memory ability were evaluated with the Y-maze and passive avoidance tests following administration of LQ...
May 30, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28554199/recombinant-human-thioredoxin-1-protects-macrophages-from-oxidized-low-density-lipoprotein-induced-foam-cell-formation-and-cell-apoptosis
#8
Hui Zhang, Qi Liu, Jia-Le Lin, Yu Wang, Ruo-Xi Zhang, Jing-Bo Hou, Bo Yu
Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and apoptosis play critical roles in the pathogenesis of atherosclerosis. Thioredoxin-1 (Trx) is an antioxidant that potently protects various cells from oxidative stress-induced cell death. However, the protective effect of Trx on ox-LDL-induced macrophage foam cell formation and apoptosis has not been studied. This study aims to investigate the effect of recombinant human Trx (rhTrx) on ox-LDL-stimulated RAW264.7 macrophages and elucidate the possible mechanisms...
May 30, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28554197/a-new-neolignan-derivative-balanophonin-isolated-from-firmiana-simplex-delays-the-progress-of-neuronal-cell-death-by-inhibiting-microglial-activation
#9
Soo Young Lim, Lalita Subedi, Dongyun Shin, Chung Sub Kim, Kang Ro Lee, Sun Yeou Kim
Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative disorders. Balanophonin, a natural neolignoid from Firmiana simplex, has been reported to have anti-inflammatory and anti-cancer effects. In this study, we aimed to evaluate the anti-neuroinflammatory effects and mechanism of Balanophonin in Lipopolysaccharide (LPS)-stimulated BV2 microglia cells...
May 30, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28605834/absorption-study-of-genistein-using-solid-lipid-microparticles-and-nanoparticles-control-of-oral-bioavailability-by-particle-sizes
#10
Jeong Tae Kim, Sonia Barua, Hyeongmin Kim, Seong-Chul Hong, Seung-Yup Yoo, Hyojin Jeon, Yeongjin Cho, Sangwon Gil, Kyungsoo Oh, Jaehwi Lee
In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were prepared with glyceryl palmitostearate. Except for the particle size, other properties of genistein-loaded solid lipid microparticles and nanoparticles such as particle composition and drug loading efficiency and amount were similarly controlled to mainly evaluate the effect of different particle sizes of the solid lipid particulate systems on drug dissolution behavior and oral bioavailability...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28605833/pig3-regulates-p53-stability-by-suppressing-its-mdm2-mediated-ubiquitination
#11
Min Jin, Seon-Joo Park, Seok Won Kim, Hye Rim Kim, Jin Won Hyun, Jung-Hee Lee
Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic cell death is triggered. Inhibiting the ubiquitination of p53 under conditions where DNA damage has occurred is therefore crucial for preventing the development of cancer, because if cells with severely damaged genomes are not removed from the population, uncontrolled growth can result...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28605832/comparison-of-reprogramming-methods-for-generation-of-induced-oligodendrocyte-precursor-cells
#12
Eun-Hye Lee, Chang-Hwan Park
Direct conversion by trans-differentiation is of growing interest in cell therapy for incurable diseases. The efficiency of cell reprogramming and functionality of converted cells are important considerations in cell transplantation therapy. Here, we compared two representative protocols for the generation of induced-oligodendrocyte progenitor cells (iOPCs) from mouse and rat fibroblasts. Then, we showed that induction of Nkx6.2, Olig2, and Sox10 (NOS) was more effective in mouse fibroblasts and that induction of Olig2, Sox10, and Zfp536 (OSZ) was more effective at reprogramming iOPCs from rat fibroblasts...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28554202/imperatorin-is-transported-through-blood-brain-barrier-by-carrier-mediated-transporters
#13
Temdara Tun, Young-Sook Kang
Imperatorin, a major bioactive furanocoumarin with multifunctions, can be used for treating neurodegenerative diseases. In this study, we investigated the characteristics of imperatorin transport in the brain. Experiments of the present study were designed to study imperatorin transport across the blood-brain barrier both in vivo and in vitro. In vivo study was performed in rats using single intravenous injection and in situ carotid artery perfusion technique. Conditionally immortalized rat brain capillary endothelial cells were as an in vitro model of blood-brain barrier to examine the transport mechanism of imperatorin...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28554201/a-benzylideneacetophenone-derivative-induces-apoptosis-of-radiation-resistant-human-breast-cancer-cells-via-oxidative-stress
#14
Jeong Eon Park, Mei Jing Piao, Kyoung Ah Kang, Kristina Shilnikova, Yu Jae Hyun, Sei Kwan Oh, Yong Joo Jeong, Sungwook Chae, Jin Won Hyun
Benzylideneacetophenone derivative (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one (JC3) elicited cytotoxic effects on MDA-MB 231 human breast cancer cells-radiation resistant cells (MDA-MB 231-RR), in a dose-dependent manner, with an IC50 value of 6 µM JC3. JC3-mediated apoptosis was confirmed by increase in sub-G1 cell population. JC3 disrupted the mitochondrial membrane potential, and reduced expression of anti-apoptotic B cell lymphoma-2 protein, whereas it increased expression of pro-apoptotic Bcl-2-associated X protein, leading to the cleavage of caspase-9, caspase-3 and poly (ADP-ribose) polymerase...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28554198/role-of-taz-in-lysophosphatidic-acid-induced-migration-and-proliferation-of-human-adipose-derived-mesenchymal-stem-cells
#15
Won Min Mo, Yang Woo Kwon, Il Ho Jang, Eun Jung Choi, Sang Mo Kwon, Jae Ho Kim
Transcriptional co-activator with a PDZ-binding motif (TAZ) is an important factor in lysophosphatidic acid (LPA)-induced promotion of migration and proliferation of human mesenchymal stem cells (MSCs). The expression of TAZ significantly increased at 6 h after LPA treatment, and TAZ knockdown inhibited the LPA-induced migration and proliferation of MSCs. In addition, embryonic fibroblasts from TAZ knockout mice exhibited the reduction in LPA-induced migration and proliferation. The LPA1 receptor inhibitor Ki16425 blocked LPA responses in MSCs...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28554196/production-of-recombinant-anti-cancer-vaccines-in-plants
#16
REVIEW
Jeong Hwan Lee, Kisung Ko
Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28274096/effect-of-enhancers-on-in-vitro-and-in-vivo-skin-permeation-and-deposition-of-s-methyl-l-methionine
#17
Ki Taek Kim, Ji Su Kim, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, WooIn Lee, Kyung Kuk Min, Min Gyu Song, Choon-Young Choi, Won-Serk Kim, Hee Kyung Oh, Dae-Duk Kim
S-methyl-L-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of -3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the in vitro skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28208014/improved-antitumor-efficacy-of-hyaluronic-acid-complexed-paclitaxel-nanoemulsions-in-treating-non-small-cell-lung-cancer
#18
Joo-Eun Kim, Young-Joon Park
Paclitaxel (PTX) is a effectively chemotherapeutic agent which is extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it is a practically insoluble drug with water solubility less than 1 µg/mL, which restricts its therapeutic application. To overcome the problem, hyaluronic acid-complexed paclitaxel nanoemulsions (HPNs) were prepared by ionic complexation of paclitaxel (PTX) nanoemulsions and hyaluronic acid (HA) to specifically target non-small cell lung cancer. HPNs were composed of DL-α-tocopheryl acetate, soybean oil, polysorbate 80, ferric chloride, and HA and fabricated by high-pressure homogenization...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28208013/sex-differences-in-autism-like-behavioral-phenotypes-and-postsynaptic-receptors-expression-in-the-prefrontal-cortex-of-tert-transgenic-mice
#19
Ki Chan Kim, Kyu Suk Cho, Sung Min Yang, Edson Luck Gonzales, Schley Valencia, Pyeong Hwa Eun, Chang Soon Choi, Darine Froy Mabunga, Ji-Woon Kim, Judy Kyoungju Noh, Hee Jin Kim, Se Jin Jeon, Seol-Heui Han, Geon Ho Bahn, Chan Young Shin
Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female population. Using a validated animal model of ASD which is the telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments and protein expression experiments to mark the difference between male and females of this animal model. After statistically analyzing the results, we found significant effects of TERT overexpression in sociability, social novelty preference, anxiety, nest building, and electroseizure threshold in the males but not their female littermates...
July 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28208010/circulating-plasma-and-exosomal-micrornas-as-indicators-of-drug-induced-organ-injury-in-rodent-models
#20
Young-Eun Cho, Sang-Hyun Kim, Byung-Heon Lee, Moon-Chang Baek
This study was performed to evaluate whether microRNAs (miRNAs) in circulating exosomes may serve as biomarkers of drug-induced liver, kidney, or muscle-injury. Quantitative PCR analyses were performed to measure the amounts of liver-specific miRNAs (miR-122, miR-192, and miR-155), kidney-specific miR-146a, or muscle-specific miR-206 in plasma and exosomes from mice treated with liver, kidney or muscle toxicants. The levels of liver-specific miRNAs in circulating plasma and exosomes were elevated in acetaminophen-induced liver injury and returned to basal levels by treatment with antioxidant N-acetyl-cysteine...
July 1, 2017: Biomolecules & Therapeutics
journal
journal
46750
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"