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Journal of Neonatal-perinatal Medicine

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https://www.readbyqxmd.com/read/29286940/sustained-lung-inflation-at-birth-for-preterm-infants-at-risk-of-respiratory-distress-syndrome-the-proper-pressure-and-duration
#1
N Abd El-Fattah, N Nasef, M F Al-Harrass, Mohammed Khashaba
BACKGROUND: Variations exist among the administered pressure and duration of sustained lung inflation (SLI) in the delivery room (DR). We aimed to evaluate the appropriate pressure and duration needed for SLI in preterm infants with respiratory distress syndrome. METHODS: We prospectively randomized 100 preterm (<32 weeks) infants to receive either conventional therapy of continuous positive airway pressure (CPAP) at 5 cm H2O, or four groups of CPAP plus a single maneuver of SLI at four regimens based on administered pressures and durations; P20D20 (Pressure of 20 cm H2O for a duration of 20 seconds), P20D10 (20 cm H2O for 10 seconds), P15D20 (15 cm H2O for 20 seconds), and P15D10 (15 cm H2O for 10 seconds) using a T-piece ventilator...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286939/clinical-profile-and-pattern-of-congenital-heart-disease-in-infants-of-diabetic-mother-and-infants-of-non-diabetic-mother-at-a-tertiary-care-hospital
#2
Suraiya Begum, Sanjoy Kumar Dey
OBJECTIVES: To assess the clinical manifestations and pattern of congenital heart diseases (CHD) in infants of diabetic mothers (IDMs) and infants of non-diabetic mothers. METHODS: A prospective cross sectional study was carried out at tertiary care center over a period of thirty months. All neonates were included in this study if CHD were identified by echocardiography within this study period. Chi-square test and Fisher's exact test were used to compare between groups...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286938/the-relationship-between-body-weight-cystatin-c-and-serum-creatinine-in-neonates
#3
Y Kandasamy, D Rudd, R Smith
BACKGROUND: Serum creatinine (SCr) measurement to determine glomerular filtration rate (GFR) in neonates has many pitfalls. Cystatin C (CysC) appears to be a more reliable biomarker. METHODS: We investigated the effect of birth weight on SCr and CysC measurements in a cohort of 74 infants, consisting of both term and ex-premature infants at term postmenstrual age. SCr and Cys C measurements were carried out at the same time. RESULTS: Eighty six infants were recruited into this study out of which complete data were available in 80 infants...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286937/hemoperitoneum-in-peripartum-a-case-series
#4
A Lemaire, M Bonnin, B Storme, A Fournet-Fayard, G Rosano, L Vernis, S Cayot, M Accocebery, P Dechelotte, L Boyer, D Gallot, E Futier, J M Constantin, J E Bazin
Hemorrhages are the first cause of perinatal deaths in French women. Thirteen percent of these deaths are not linked to obstetrical problems but rather to hemoperitoneum. These incidents are under-diagnosed and as a result, treatment is delayed and fetal and maternal mortality increases. We report three cases of patients, all White female in their last trimester of a non-problematic pregnancy presenting with hemoperitoneum and resulting in different outcomes. The analysis of published materials and of our cases leads us to infer that a diagnosis of hemoperitoneum must be considered in pregnant women when abdominal pain, symptoms of shock and a decrease in hemoglobin are associated...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286936/haddad-syndrome-novel-association-with-braf-mutation
#5
Suleiman Al Dakhoul
This is a report of a 36 week male infant who suffered abdominal distension and difficulty opening bowels within first few days of life and showed a pattern of hypoventilation and apnea associated with sleep. His diagnostic studies confirmed the diagnosis of congenital central hypoventilation syndrome CCHS (PHOX2B mutation) and Hirschsprung's disease and later found a further mutation of BRAF oncogene. This describes a novel association between these mutations and the shared qualities of tumorigenesis between BRAF and PHOX2B...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286935/neonatal-methicillin-resistant-staphylococcus-aureus-colonization-and-infection
#6
Yoko Shirai, Hiroko Arai, Kazutomo Tamaki, Hiroe Konishi, Yasuhiro Kawase, Norikazu Shimizu, Kazuhiro Tateda, Hitoshi Yoda
INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) is a common etiological agent of a life-threatening infection in neonatal intensive care units (NICUs). Neonates with very low birth weight and patients with serious diseases are more likely to be exposed to invasive procedures which make them at a high risk of MRSA colonization and infection. Since MRSA colonization is a risk factor for MRSA infection, prevention of MRSA transmission is an important issue in NICUs. NICUs in Japan practice standard contact precautions and active surveillance cultures (ASC) to prevent MRSA transmission...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286934/use-of-prophylactic-antibiotics-in-women-with-previable-prelabor-rupture-of-membranes
#7
S K Dotters-Katz, O Myrick, M Smid, T A Manuck, K A Boggess, W Goodnight
OBJECTIVE: To measure the effect of prophylactic antibiotics given at time of previable prelabor rupture of membranes (PROM) on latency. METHODS: Single center, retrospective cohort study of singleton pregnancies with previable (<23 0/7weeks) PROM. Antibiotics were given at clinician discretion. The primary outcome was latency, defined as duration of time between previable PROM and delivery. Secondary outcomes included delivery at ≥ 23weeks, infant survival, and maternal morbidity...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286933/clinical-and-nutritional-outcomes-of-two-liquid-human-milk-fortifiers-for-premature-infants
#8
Shabnam Lainwala, Natalia Kosyakova, Ann Marie Spizzoucco, Victor Herson, Elizabeth A Brownell
BACKGROUND: In preterm infants fortification of human milk with human milk fortifiers (HMF) to optimize nutrition and growth is standard practice. We compared clinical, nutrition and growth outcomes in infants receiving two types of liquid HMF (LHMF). METHODS: Clinical, nutrition and growth outcomes were compared between infants admitted to a level IV NICU, and born with birth weight less than or equal to 1800 grams, between 10/1/2014-12/31/2014 and received human milk with acidified LHMF (ALHMF) and between 1/1/2015-4/31/2015 and received human milk with heat treated LHMF (HTLHMF)...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286932/dexamethasone-effect-on-heart-rate-variability-in-preterm-infants-on-mechanical-ventilation
#9
Corrie J Alonzo, Karen D Fairchild
BACKGROUND: Dexamethasone is administered to some preterm infants with chronic lung disease to facilitate weaning from mechanical ventilation. Heart rate characteristics (HRC), including heart rate variability (HRV), may be impacted by glucocorticoids and may predict extubation readiness. A commercially available monitor developed for sepsis detection continuously calculates HRV and an HRC index, which are inversely related. OBJECTIVES: Determine the impact of dexamethasone on HRV and the HRC index, in relation to extubation success...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286931/newborn-drug-testing-practices-in-iowa-birthing-hospitals
#10
K E Wood, P Smith, M D Krasowski
OBJECTIVES: Federal law mandates states to have policies and procedures to identify newborns exposed to maternal substance use during pregnancy. National guidelines for newborn drug testing are lacking; therefore, procedures are variable and determined by state law and local practices. In Iowa, maternal substance use during pregnancy is considered child abuse and must be reported.The objective of this study was to identify newborn drug testing policies and procedures among birthing hospitals in Iowa...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286930/hypoxic-ischemic-brain-injury-planned-delivery-before-intrapartum-events
#11
David Odd, Axel Heep, Karen Luyt, Tim Draycott
BACKGROUND: Mothers are increasingly given greater control over many of the choices around birth, although there is little robust evidence to inform these choices. After an infant is born with HIE the question of whether it was predictable, or preventable, is often raised. Intrapartum 'sentinel' events and antenatal predictors of HIE have been well described, however there is little evidence how antenatal and intrapartum factors interact. This is particularly important when elective delivery by lower segment caesarean section (LSCS) has been shown to be beneficial in high risk groups...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286929/correlation-of-hematocrit-and-apgar-scores-in-newborns-of-women-with-hypertensive-disorders-in-pregnancy
#12
Helen Chioma Okoye, Benedict Nwogoh, Odutola Israel Odetunde
OBJECTIVES: To compare the incidence of polycythemia in newborns of women with hypertensive disorders in pregnancy (HDP) with those of normotensive mothers, to determine the incidence of perinatal stress using Apgar scores and to correlate hematocrit with Apgar scores in these newborn. STUDY DESIGN: This was a hospital-based comparative study conducted in the University of Port Harcourt Teaching Hospital, Nigeria. MAIN OUTCOME MEASURES: Apgar scores of 200 newborns- 100 from mothers with HDP (case group) and 100 from normotensive mothers (control group)- were taken at 1st and 5th minute of birth and cord blood samples collected to determine hematocrit...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286928/long-term-neurodevelopment-outcome-of-caffeine-versus-aminophylline-therapy-for-apnea-of-prematurity
#13
S Khurana, M Shivakumar, G V Sujith Kumar Reddy, P Jayashree, Y Ramesh Bhat, L E S Lewis
OBJECTIVE: Methylxanthines are the most commonly prescribed drug in neonatal setups. However, Clinicians show indecision in choosing the right agent for Apnea of Prematurity in most of the developing countries. Present study aimed to compare rate of mortality and survival with normal neurodevelopment outcome at 18 to 24 months of corrected age, between Caffeine- and Aminophylline-treated infants for apnea of prematurity. METHODS: 240 infants were randomly allocated to caffeine and aminophylline for apnea of prematurity during February 2012 to January 2015...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286927/carnitine-deficiency-in-preterm-infants-a-national-survey-of-knowledge-and-practices
#14
M A Clark, R E K Stein, Ellen J Silver, Sabeen Khalid, M Fuloria, N V Esteban-Cruciani
OBJECTIVE: Lipid supplementation improves developmental outcomes in preterm infants. Carnitine is essential for lipid metabolism; however, despite high risk for carnitine deficiency, there are no standards for carnitine supplementation in preterm infants receiving total parenteral nutrition (TPN). Our objective was to assess knowledge, beliefs and practices regarding preterm carnitine deficiency and supplementation among neonatal practitioners. METHODS: Cross-sectional electronic survey administered via a nationally representative listserv of neonatal practitioners...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29286926/effects-of-in-utero-exposure-to-selective-serotonin-reuptake-inhibitors-and-venlafaxine-on-term-and-preterm-infants
#15
A N Hogue, M E Temple-Cooper, M Lagzdins, S Worley, J Scwersenski, R Floyd, F Saker
OBJECTIVE: We hypothesized that in-utero SSRI exposure affects Apgar scores and immediate post-delivery oxygen requirements. STUDY DESIGN: SSRI in-utero exposure was assessed retrospectively in preterm neonates ≥ 28 weeks gestation and term neonates. Primary outcome was Apgar <7 at five minutes and delivery room oxygen requirements. Secondary endpoints included one-minute Apgar, length of stay, birth weight, and NICU admission. RESULTS: Fifty-one preterm and 117 term neonates were exposed to a SSRI; mostly to sertraline...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28854519/isolated-neonatal-mri-punctate-white-matter-lesions-in-very-preterm-neonates-and-quality-of-life-at-school-age
#16
C Arberet, M Proisy, J L Fausser, M Curt, P Bétrémieux, C Tréguier, C Rozel, P Pladys
OBJECTIVE: To study the quality of life at school age of very preterm infants presenting isolated punctate periventricular white matter lesions (IPWL) on late-preterm or term magnetic resonance imaging (MRI). METHODS: In 1996-2000, 16 of the 131 very preterm neonates explored by MRI were found to have IPWL. At the age of 9-14, 12 children from the IPWL group were compared with 54 children born preterm but with a normal MRI (no lesion). Quality of life (Health Status Classification System Pre School questionnaire), school performance, and motor outcome were investigated...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28854518/intestinal-perforation-in-the-premature-infant
#17
K Vongbhavit, M A Underwood
OBJECTIVE: To compare demographic data, prenatal and postnatal characteristics, laboratory data, and outcomes in a cohort of premature infants with spontaneous ileal perforation (SIP), surgical necrotizing enterocolitis (sNEC) and matched controls. METHODS: A retrospective case-control study of infants with intestinal perforation with a birth weight (BW) less than 2,000 grams and gestational age (GA) less than 34 weeks and infants without perforation matched for BW (±150 grams) and GA (±1week)...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28854517/the-effect-of-meconium-exposure-on-the-expression-and-differentiation-of-amniotic-fluid-mesenchymal-stem-cells
#18
T J Jensen, J E Shui, C M Finck
BACKGROUND: The goal of this study was to determine if exposure to meconium would alter the phenotype of amniotic fluid mesenchymal stem cells (AF-MSCs) and the ability of these cells to be differentiated into distal airway type cells. METHODS: Meconium was collected, lyophilized and resuspended in PBS at 3 different concentrations (high, medium, and low). AF-MSCs were cultured in the presence of this meconium suspension for 8 hours and then analyzed for changes in gene expression...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28854516/risk-of-morbidity-following-catheter-removal-among-neonates-with-catheter-associated-bloodstream-infection
#19
J S Garland, S Kanneberg, K A Mayr, D M Porter, A Vanden Heuvel, J Kurziak, T L McAuliffe
OBJECTIVE: We hypothesized that infectious morbidities following percutaneously inserted central venous catheter (PICC) removal would be greater among neonates with central-line associated bloodstream infection (CLBASI). STUDY DESIGN: This retrospective cohort study, included all neonates who required a PICC over a ten-year period. Outcomes assessed following PICC removal included: late bloodstream infection, rule-out sepsis workups, need for a subsequent PICC and antibiotic days and PICC days after PICC removal...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28854515/intravenous-immunoglobulin-in-the-management-of-a-rare-cause-of-hemolytic-disease-of-the-newborn-anti-sara-antibodies
#20
Rohini Venkataraman, Kamran Yusuf
Hemolytic disease of newborn (HDN) is a condition that develops in a fetus, when the IgG molecules produced by the mother pass through the placenta and attack the fetal red blood cells. HDN can occur due to Rh and ABO incompatibilities between the mother and the fetus as well as due to other allo-immune antibodies belonging to Kell (K and k), Duffy (Fya), Kidd (Jka and Jkb), and MNS (M, N, S, and s) systems. Role of intravenous immunoglobulin in management of HDN is not clear.SARA red blood cell antigen, first discovered in 1990 is a low frequency antigen...
2017: Journal of Neonatal-perinatal Medicine
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