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Journal of Neonatal-perinatal Medicine

S Wheeler, K Pryor, B Antczak, T Truong, A Murtha, P Seed
OBJECTIVE: Pregnant non-Hispanic blacks (NHB) have increased vaginal microbiome diversity compared to non-Hispanic whites (NHW) which may contribute to increased preterm birth. Cervical microbiome diversity is poorly characterized in pregnancy, therefore our objective was to correlate cervical microbiota diversity with cervico-vaginal inflammation by race and delivery timing. STUDY DESIGN: Pregnant women were recruited in the first and second trimesters. A sterile cervical swab and saline lavage were collected at a single time point...
September 4, 2018: Journal of Neonatal-perinatal Medicine
A Petrova, M Karats, R Mehta
BACKGROUND: The purpose of this study was to identify the pattern and factors associated with changes in cranial ultrasound (CUS) -detected findings in infants born at or less than 28 weeks of gestation. METHODS: We compared readings of CUS performed at the end of the first week of life and at 4-5 weeks of age. Alteration of CUS findings was classified as: (i) unchanged, if no deviation was detected (Group 1); (ii) worsening, if there were new findings (Group 2); and (iii) improvement, if there was normalization or reduction in severity (Group 3)...
August 23, 2018: Journal of Neonatal-perinatal Medicine
E Chung, T Abraham, N N Saad, A Gad
BACKGROUND: Study aims to evaluate whether vancomycin dosing from published dosing algorithms correlate with the attainment of target troughs of 10 to 20 mg/L. METHODS: NICU patients who received minimum three doses of vancomycin and had a trough level met inclusion criteria. Dosing information was retrospectively evaluated to determine which published dosing regimen was followed. Dosing algorithms used were matched to NeoFax/Harriet Lane, renal-function directed dosing, and weight-directed dosing, in which the latter two can be found in Pediatric and Neonatal Lexi-Drugs...
August 23, 2018: Journal of Neonatal-perinatal Medicine
F Ricci, S Stagi, F Messa, M de Martino
We report a 3-month-old male with Down syndrome (DS), prolonged jaundice and poor weight gain, that showed biliary lithiasis and undiagnosed congenital hypothyroidism (CH).CH should be considered in DS, especially in presence of gastrointestinal symptoms or malformations. Clinicians should be aware of the increased risk of gallstones in hypothyroid children with DS, even in neonatal age.
August 23, 2018: Journal of Neonatal-perinatal Medicine
C S Crabtree, M Pakvasa, P G Radmacher, D H Adamkin
OBJECTIVE: The study objective was to explore the relationship between necrotizing enterocolitis (NEC) and packed red blood cell (pRBC) transfusion in very low birth weight (VLBW) neonates (<1500 g). STUDY DESIGN: A six-year retrospective chart review of VLBW infants with NEC (Bell's Stage > II) and a pRBC transfusion within 48 hours of diagnosis. Prenatal data, postnatal course, transfusion history, and NEC outcomes were reviewed. The transfusion associated necrotizing enterocolitis (TANEC) cases were matched with controls (1:2) who were transfused but did not develop NEC as to proximity of birth date, gestational age, and receipt of transfusion...
August 23, 2018: Journal of Neonatal-perinatal Medicine
L Davidson, M Rawat, S Stojanovski, P Chandrasekharan
BACKGROUND: Mitragyna speciosa, also known as kratom, is obtained from the coffee plant family 'Rubiaceae.' Kratom is available in the form of capsules, whole, processed and powdered leaves and as liquids. Secondary to its 'natural herb' status and opioid effects, it is misconceived to be a safe alternative for the treatment of chronic pain. The use of kratom has increased by tenfold in the United States since 2010. METHODS AND RESULTS: We report a term neonate who was born to a chronic kratom user and required treatment with opiates for neonatal drug withdrawal...
August 22, 2018: Journal of Neonatal-perinatal Medicine
A Elmekkawi, H Maulidi, W Mak, A Aziz, K Lee
OBJECTIVE: To compare outcomes of peripherally inserted central catheters (PICCs) placed in the upper extremity (UE) versus the lower extremity (LE) in a quaternary medical-surgical neonatal intensive care unit (NICU). RESULTS: We analyzed a total of 365 PICCs of which 250 (68% ) were removed for the end of therapy and 115 (32% ) were removed due to complications. Patients who had UE insertions compared to LE insertions were of lower gestational age (median (IQR)) 30 (26, 35) vs...
August 22, 2018: Journal of Neonatal-perinatal Medicine
M Olaya-C, F Michael, G Fabian, J Luis Silva, J E Bernal
INTRODUCTION: The umbilical cord (UC) is a vital structure; its alterations affect the newborn and neurological impact can be permanent. Paradoxically, factors that determine it remain unknown. We explore the differential VEGF protein expression in the UC's proximal and distal portions in relation to the hypothesis that the UC has differential growth and that VEGF plays a role in it. METHODS: An observational analytical study was performed. One UC segment was taken proximal to fetus and another distal; both were randomly processed; VEGF immunohistochemical analysis was performed; two blinded pathologists read results...
August 22, 2018: Journal of Neonatal-perinatal Medicine
S K Yadav, K Venkatnarayan, K M Adhikari, R Sinha, S S Mathai
OBJECTIVE: To evaluate the efficacy of gastric lavage (GL) in preventing feed intolerance in babies born through Meconium stained amniotic fluid (MSAF). STUDY DESIGN: In this randomized trial conducted at a tertiary care hospital, neonates born of MSAF after 34 weeks period of gestation requiring routine care were randomly allocated to GL with 10 ml/kg of normal saline. The control group did not receive GL. The subjects were monitored for first 24 hours in predefined time epochs...
August 22, 2018: Journal of Neonatal-perinatal Medicine
V Demeulemeester, H V Hauthem, F Cools, J Lefevere
Neonatal seizures are frequent in neonatal intensive care and the most common cause is perinatal asphyxia. Among other causes, toxin exposure is rare.We present a boy with an uneventful vaginal birth, who presented one hour after birth with apnea, hypotonia, mydriasis, tongue fasciculation, and tonic seizures. There was no hypoxic ischemic encephalopathy and brain imaging was normal. Toxicology screening revealed a toxic concentration of lidocaine in his blood. The intoxication was transplacental, as a cord blood sample confirmed the toxic level...
August 21, 2018: Journal of Neonatal-perinatal Medicine
H Halil, M Buyuktiryaki, F Yavanoglu Atay, M Yekta Oncel, N Uras
OBJECTIVE: Patent ductus arteriosus is a common problem frequently encountered in preterm infants. We aimed to study the risk factors associated with reopening of patent ductus arteriosus and their short term outcomes in preterm infants. METHODS: A total of 162 preterm infants born between November 2013 and December 2015 with gestaional age less than 32 weeks and treated for hemodynamically significant patent ductus arteriosus are included in our study. RESULTS: 113(69...
August 21, 2018: Journal of Neonatal-perinatal Medicine
S Watanabe, Y Kondo, A Naoe, T Yasui, T Suzuki, F Hara, N Uga, M Miyata, H Boda
PURPOSE: Recently, the number of births using assisted reproductive technologies (ART) has increased. An associated increase in the incidence of congenital malformations in babies conceived using this technology has also been reported. Therefore, we aimed to investigate the rate of malformations in babies with neonatal surgical diseases, who were conceived using ART. MATERIALS AND METHODS: Between January 2007 and December 2016, 1737 patients were admitted to our hospital...
August 21, 2018: Journal of Neonatal-perinatal Medicine
W A Seliem, A M Sultan
INTRODUCTION: This study was conducted to find out the bacterial causes of early onset neonatal sepsis and their susceptibility pattern for different classes of antibiotics in neonates admitted to neonatal intensive care unit (NICU) of Mansoura-Egypt. METHODS: A descriptive cross-sectional study was conducted. All admitted newborns to our study were infants at <72 hours of age with clinical features of sepsis or product of an in-house delivery at Mansoura University Hospital with risk factors for neonatal sepsis...
August 21, 2018: Journal of Neonatal-perinatal Medicine
M Assad, M Spaight, D Sink, J Martin
Non-obstetrical fetal head injury is an unusual clinical event. While multiple case reports describe motor vehicle collisions resulting in intrauterine fetal skull fractures, management of these injuries has not been emphasized. We report a case of a depressed fetal skull fracture with massive subgaleal and subperiosteal hemorrhage requiring neurosurgical intervention with good clinical outcomes for both mother and infant dyad.
August 21, 2018: Journal of Neonatal-perinatal Medicine
H Nagasawa, R Motz, C Hamada, Y Kohno, Y Yamada
BACKGROUND: We had reported on the left ventricular end-diastolic dimension (LVDd) in normal children from the premature/neonatal period to the adolescence period by using two-dimensional echocardiography, and formulated equations to evaluate normal LVDd values by using body height as an index. There was an inflection point at around birth that seemed relevant to the fetal and neonatal periods for the relation of LVDd and body height. METHODS: We aimed to reveal the true inflection point and its meaning by using change point regression analysis...
August 20, 2018: Journal of Neonatal-perinatal Medicine
L Cordero, M R Stenger, M B Landon, C A Nankervis
OBJECTIVE: To examine the effects of early breastfeeding (eBF) or early formula feeding (eFF) on hypoglycemia and on BF initiation in infants born to women with pregestational diabetes mellitus (PGDM) who intended to BF. METHODS: Retrospective cohort investigation of 554 women with PGDM and their infants (IDMs) who delivered during 2008-2016. The first feeding (BF or FF) was considered early if given within 4 hours from birth. RESULTS: 282 (51%) IDMs were admitted to the Well Baby Nursery...
August 20, 2018: Journal of Neonatal-perinatal Medicine
T Pham, C VanWoudenberg, I Chandrasekar
A male fetus was delivered by emergent caesarean section after a term pregnant mother was caught in crossfire and sustained gunshot injury to her abdomen. Examination of the infant was unremarkable except for a small laceration of the scalp at the anterior fontanelle. Skull radiography showed a dense bullet shaped opacity in the brain. He was managed conservatively and was discharged home on full feeds with normal neurological examination. He developed seizures and progressive hydrocephalus, and underwent a ventriculoperitoneal (VP) shunt placement at 5 weeks of age...
August 20, 2018: Journal of Neonatal-perinatal Medicine
A Das, M Mhanna, J Sears, J W Houdek, N Kumar, D Gunzler, D Einstadter, M Collin
BACKGROUND: The association between saturation of peripheral oxygenation (SpO2) fluctuation and severity of retinopathy of prematurity (ROP) is well elucidated in extremely low birth weight (ELBW) infants. Time spent in the Target range of SpO2 is also associated with the severity of ROP. METHODS: In a prospective observational study, the SpO2 of all ELBW infants admitted to our unit were monitored for the first four weeks of life, and averaged every minute for analysis...
August 4, 2018: Journal of Neonatal-perinatal Medicine
S Dizon, S Bhat Hoffman
OBJECTIVE: Determine how blood pressure differs in premature infants born small for gestational age (SGA). DESIGN: A retrospective study was conducted on inborn infants 24-32 weeks gestation. Mean arterial blood pressure (MAP) was collected and averaged every 12 h for the first 96 h of life. For each time point, the difference MAP in SGA vs. AGA infants was evaluated with t-testing. Linear mixed-effects modeling was performed to model MAP over time accounting for GA, BW, gender, and SGA status...
July 31, 2018: Journal of Neonatal-perinatal Medicine
S Suzuki
To predict the presence of histological funisitis at term, we examined the symptoms of clinical chorioamnionitis in 251 cases of maternal fever of 38 degrees or higher during labor at term. The examined symptoms in this study were clinical maternal findings (uterine fundal tenderness, maternal tachycardia, purulent or foul amniotic fluid or cervical discharge, and maternal white blood cell count) and fetal tachycardia. In these cases, microscopic histopathological analysis of the placenta was performed after delivery...
July 19, 2018: Journal of Neonatal-perinatal Medicine
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