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Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/30121990/does-melatonin-and-melatonin-agonists-improve-the-metabolic-side-effects-of-atypical-antipsychotics-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Stanley C Igwe, Francesco Brigo
Atypical antipsychotics (AAPs) are increasingly used for the treatment of psychotic disorders but are known to be associated with metabolic abnormalities. This study is a systematic review and meta-analysis of randomized controlled trials (RCTs) studying the effectiveness of melatonin for the amelioration of AAP-induced metabolic syndrome. The MEDLINE (accessed via PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials, PsycINFO, LILACS, CINAHL, and OpenGrey databases were searched for RCTs without language restrictions...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121989/ventricular-arrhythmia-during-tracheal-intubation-and-extubation-under-general-anesthesia-possibly-induced-by-amisulpride-a-case-report
#2
Bo Fang, Hong Ma
We are presenting the first documented case of amisulpride related ventricular arrhythmia during tracheal intubation and extubation under general anesthesia in an 48 year-old female with psychiatric history of chronic schizophrenia who was treated with amisulpride. This case suggests the threshold of perioperative arrhythmia is possibly decreased in patients with long-term antipsychotic medication. So, the potential risk of antipsychotics-induced perioperative arrhythmia should be evaluated, as well as heart rhythm monitoring, prophylactic use of antiarrhythmic drugs, and preoperative adjustment of antipsychotics should be considered...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121988/usefulness-of-pharmacogenetic-analysis-in-psychiatric-clinical-practice-a-case-report
#3
Manuel A Franco-Martin, Francisco Sans, Belen García-Berrocal, Cristina Blanco, Carlos Llanes-Alvarez, María Isidoro-García
There are many factors involved in the effectiveness and efficiency of psychiatric drug treatment. One of them is psychotropic drug metabolism, which takes place mostly in the liver through the P450 enzyme system. However, there are genotypic variants of this system's enzymes that can directly affect both the efficacy and the onset of side effects of a given therapeutic regimen. These genotypic changes could partly explain the lack of efficacy of treatment in certain patients. We report the case of a patient diagnosed with bipolar type I disorder that presented multiple and frequent manic episodes in which the efficacy and tolerability of several pharmacological regimens with mood stabilizers and antipsychotics was scarce...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121987/successful-management-of-clozapine-induced-akathisia-with-gabapentin-enacarbil-a-case-report
#4
Masahiro Takeshima, Hiroyasu Ishikawa, Yuka Kikuchi, Takashi Kanbayashi, Tetsuo Shimizu
The management of clozapine (CLZ)-induced adverse events affects patient prognoses. Akathisia is a relatively rare adverse event related to CLZ administration and thus the management of this syndrome is not well established. Here, we report a case of treatment-resistant schizophrenia wherein CLZ-induced akathisia was successfully managed with gabapentin enacarbil (GE). The patient was a 39-year-old woman who had been treated with atypical antipsychotics other than CLZ for three years with poor tolerability...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121986/amenorrhea-as-a-side-effect-of-low-dose-aripiprazole-an-adolescent-case
#5
Gulen Guler, Meryem Ozlem Kutuk, Halil Kara
Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known as a dopamine stabilizer antipsychotic which can be used to improve hyperprolactinemia. In this report, it was described that an adolescent patient experienced amenorrhea after adding very low dose aripiprazole to ongoing fluoxetine treatment regime for major depressive disorder...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121985/the-effects-of-continuation-maintenance-electroconvulsive-therapy-on-reducing-hospital-re-admissions-in-patients-with-treatment-resistant-schizophrenia
#6
Kyung Mook Choi, Soo-Hee Choi, Jung Kyung Hong, Mi Hyun Lee, Joon Hyung Jung, Sang Hoon Oh, Dong Chung Jung, Sung Nyun Kim
Objective: Continuation-maintenance electroconvulsive therapy (C/M-ECT) is used to prevent relapse or recurrence in patients with severe mental illnesses. We aimed to investigate the effect of C/M-ECT on reducing hospital re-admissions in patients with treatment-resistant schizophrenia. Methods: We applied a mirror-image design by retrospectively examining re-hospitalization rates of 18 patients with schizophrenia spectrum disorders. We compared the numbers of psychiatric admissions during the actual period over which C/M-ECT was administered with the same period prior to the beginning of C/M-ECT...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121984/improving-the-screening-instrument-of-bipolar-spectrum-disorders-weighted-korean-version-of-the-mood-disorder-questionnaire
#7
Narei Hong, Won-Myong Bahk, Bo-Hyun Yoon, Kyung Joon Min, Young Chul Shin, Duk-In Jon
Objective: It is not easy to diagnose bipolar disorders accurately in the clinical setting. Although Korean version of the Mood Disorder Questionnaire (K-MDQ) is easily administered, it still has weakness regarding case finding. In this study, we suggest a new weighted version of the K-MDQ to increase its screening power. Methods: Ninety-five patients with bipolar disorders and 346 controls (patients with schizophrenia, patients with depressive disorders, patients with anxiety disorders, and subjects without any psychiatric disease) were enrolled in this study...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121983/neural-signature-for-auditory-hallucinations-in-schizophrenia-a-high-resolution-positron-emission-tomography-study-with-fludeoxyglucose-18-f
#8
Jong-Hoon Kim, Young Don Son, Jeong-Hee Kim, Hyo-Jong Lee, Nam-In Kang, Gyung Ho Chung, Jong-Il Park, Yin Cui, Woo-Sung Kim, Young-Chul Chung
Objective: Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia. Methods: We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed incluing Psychotic Symptom Rating Scale for Auditory Hallucinations...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121982/screening-with-the-korean-version-of-the-mood-disorder-questionnaire-for-bipolar-disorders-in-adolescents-korean-validity-and-reliability-study
#9
Se-Hoon Shim, Jonghun Lee, Jye-Heon Song, Beomwoo Nam, Bo-Hyun Yoon, Ha-Young Jin, Hyung-Mo Sung, Jong-Hyun Jeong, Sae-Heon Jang, Duk-In Jon, Young Sup Woo, Won-Myong Bahk
Objective: This study aimed to evaluate the validity and reliability of a Korean version of the Mood Disorder Questionnaire-Adolescent version (K-MDQ-A) as a screening instrument for bipolar disorders in adolescents. Methods: One hundred two adolescents with bipolar disorders and their parents were recruited from November 2014 to November 2016 at 7 training hospitals. One hundred six controls were recruited from each middle school in two cities of South Korea. The parent version of the original MDQ-A was translated into Korean...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121981/does-blood-flow-change-according-to-mood-blood-rheology-in-bipolar-disorder
#10
Tevfik Kalelioglu, Murat Kocabiyik, Burcu Kok, Pelin Unalan, Sule Sozen, Ozge Yuksel, Nesrin Karamustafalioglu
Objective: Bipolar disorder (BD) is associated with increased rates of cardiovascular diseases. There is growing evidence that blood viscosity may have a common role, correlated with well-known major risk factors that promote cardiovascular disease. In this study we aimed to investigate the whole blood viscosity (WBV) in different stages of BD. Methods: A total of 121 bipolar patients and 41 age-gender matched healthy controls were included. Forty-four of bipolar patients were in manic, 35 were depressed and 42 were in euthymic state...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121980/depressive-temperament-in-relatives-of-patients-with-schizophrenia-is-associated-with-suicidality-in-patients-with-schizophrenia
#11
Esra Yazici, Zerrin Cimen, Ipen Ilknur Unlu Akyollu, Ahmet Bulent Yazici, Betul Aslan Turkmen, Atila Erol
Objective: Suicide is a major cause of death in patients with schizophrenia; thus, predicting and preventing suicide in patients with schizophrenia is examined in various studies. Affective temperaments which are accepted as precursors of mood disorders may be an important factor in predicting suicidality. This study investigated the relationship between affective temperaments of relatives of schizophrenia patients and suicidal thoughts and other clinical correlates of patients with schizophrenia...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121979/brain-functional-magnetic-resonance-imaging-cue-reactivity-can-predict-baclofen-response-in-alcohol-use-disorders
#12
Bharath Holla, Sheshachala Karthik, Jitendriya Biswal, Biju Viswanath, Deepak Jayarajan, Rose Dawn Bharath, Ganesan Venkatasubramanian, Vivek Benegal
Objective: Baclofen is a promising treatment for alcohol use disorders (AUD), although its clinical response in humans is mixed. The present study aimed at investigating the impact of baclofen treatment on cue-induced brain activation pattern and its relationship with relapse outcomes. Methods: Twenty-three inpatients with AUD underwent a functional magnetic resonance imaging cue-reactivity task before beginning medication with baclofen and 2 weeks later. Twelve additional inpatients with AUD, who did not receive any anticraving medications, formed the control group...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121978/increased-bone-mineral-density-after-abstinence-in-male-patients-with-alcohol-dependence
#13
Tae-Hong Song, Joo-Cheol Shim, Do-Un Jung, Jung-Joon Moon, Dong-Wook Jeon, Sung-Jin Kim, Min-Kyung Oh
Objective: This study aimed to compare the bone mineral density of male patients with alcohol dependence with that in healthy controls and to assess changes in bone density after abstinence. Methods: Forty-four inpatients with confirmed the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnosis of alcohol abuse and 42 controls were recruited. Bone density was determined with dual-energy X-ray absorptiometry in the lumbar spine as well as in the femoral neck, trochanter, and Ward's triangle regions of the proximal right femur...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121977/decreased-serum-glutamate-levels-in-male-adults-with-internet-gaming-disorder-a-pilot-study
#14
Soo-Hyun Paik, Mi Ran Choi, Su Min Kwak, Sol Hee Bang, Dai-Jin Kim
Objective: Alteration in glutamatergic neurotransmission and dopaminergic dysfunction has been implicated in both the initiation and expression of addiction related behaviors. This pilot study was aimed to investigate the serum levels of glutamate and dopamine in adults with internet gaming disorder (IGD). Methods: We measured serum levels of glutamate and dopamine in male participants with IGD (n=26) and age-matched healthy controls (n=25). Clinical interviews were performed to identify IGD and to rule out psychiatric comorbidities...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121976/serial-progression-from-attention-deficit-hyperactivity-disorder-to-alcohol-use-disorder-serial-multiple-mediated-effects-of-externalizing-disorders-and-depression
#15
Jung Min Jo, Sung Doo Won
Objective: Externalizing disorders such as attention-deficit/hyperactivity disorder (ADHD), conduct disorder and antisocial personality disorder, as well as depression are common comorbidities in alcohol use disorder (AUD). The current study focused on the temporal relationship between the onsets of these disorders and AUD, and investigated the serial multiple mediator model of externalizing disorders (e.g., ADHD) and depression on AUD. Methods: We analyzed the mediated effects of the Adult ADHD Self-Report Scale (ASRS), the Barratt Impulsiveness Scale motor (BIS_M) and the Beck Depression Inventory (BDI) on Korean version of the Alcohol Dependence Scale (ADS_K) using the multiple-step multiple mediation procedure regression analysis...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121975/dissociative-experience-in-unipolar-and-bipolar-depression-exploring-the-great-divide
#16
Seshadri Sekhar Chatterjee, Arghya Pal, Nitu Mallik, Malay Ghosal, Goutam Saha
Objective: Unipolar and bipolar depression (UD and BD) differ strikingly in respect to neurobiology, course and management, but their apparent clinical similarity often leads to misdiagnosis resulting in chronicity of course and treatment failure. In this study we have tried to assess whether UD and BD can be differentiated on the basis of their dissociative symptoms. Methods: Thrty-six UD patients and 35 BD patients in active episodes, without any psychiatric comorbidity were selected from outpatient department and compared for depressive and dissociative symptoms using Hamilton Depression Rating Scale and Dissociative Experience Scale-II (DES-II)...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121974/different-endocrine-effects-of-an-evening-dose-of-amitriptyline-escitalopram-and-placebo-in-healthy-participants
#17
Lukas Frase, John Peter Doerr, Bernd Feige, Maria Rechenbach, Bernd L Fiebich, Dieter Riemann, Christoph Nissen, Ulrich Voderholzer
Objective: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans. Methods: Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30121973/microglia-and-autism-spectrum-disorder-overview-of-current-evidence-and-novel-immunomodulatory-treatment-options
#18
REVIEW
Jung Won Kim, Ji Yeon Hong, Seung Min Bae
Autism spectrum disorder is a rapidly increasing heterogeneous neurodevelopmental syndrome, remarked by persistent deficit in social communication, and restricted, repetitive patterns of behavior and interest. Lately, maternal immune activation and micgroglial dysfunction in the developing brain have been gaining mounting evidence and leading to studies of various novel agents as potential treatment options. A few immunomodulatory treatment options-luteolin, minocycline, suramin, vitamin D, gut microbiota-are discussed in the current article, regarding the current understanding of their mechanisms and evidence for potential clinical use...
August 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29739141/high-dose-ofloxacin-induced-bimodal-hallucinations-in-a-four-years-old-child
#19
LETTER
Manish Pawar, Shamsundar Jadhav
No abstract text is available yet for this article.
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29739140/quetiapine-related-acute-paralytic-ileus-in-a-bipolar-i-disorder-patient-with-successful-low-dose-amisulpride-substitution-a-case-report
#20
Shun-Ting Chiang, Chen-Chia Lan
The mechanism of medication-induced gastrointestinal hypomotility is primarily caused by muscarinic cholinergic antagonism. This effect may cause constipation and paralytic ileus, which may lead to fatal complications. A 51-year-old woman was admitted due to manic episode recurrence. She developed paralytic ileus under quetiapine use and treated successfully under low dose amisulpride use. The related mechanism, associated risk factors, and the rationale for medication switch are discussed.
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
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