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Pakistan Journal of Medical Sciences Quarterly

Jenny Lyn Y Uy, José Florencio F Lapeña
A 3-year-old boy referred for persistent tongue bleeding was diagnosed with a rare self-mutilating disease that had also affected his lip and fingers. He underwent multiple odontectomy and partial glossectomy and continues to undergo behavior therapy and on-demand splints and restraints. He has stopped self-biting and has gained appetite and weight. Lesch-Nyhan Syndrome can cause significant morbidity including self-inflicted oral hemorrhage and emergent measures are not easily decided. The long-term management of its neurobehavioral symptoms is problematic and multidisciplinary, and health providers remain challenged to find the best treatment, prolong lifespan and improve quality of life within their respective contexts...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Asude Aksoy, Koray Karabulut, Hakan Artas, Ahmet Kilicarslan, Sertac Usta, Ibrahim Halil Bahcecioglu
Hepatocellular cancer is one of the most common and fatal cancer tumor worldwide. However, the obtained results are questionable in terms of medical treatment of hepatocellular cancer. The muscle, soft tissue and cutaneous metastases of hepatocellular cancer, for instance, are rare and may result from interventional procedures. Seeding of tumor along the biopsy needle upon percutaneous biopsy is a very rare phenomenon. We report a very rare case of a 79 -year- old man, known to be hepatitis C virus carrier with a metastatic tumor in abdominal wall caused by seeding of tumor after three years following a percutaneous biopsy procedure...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Shubo Zuo, Na Xu, Zhongkun Li, Na Li, Hong Xia, Hongtao Ren, Huizheng Bao
OBJECTIVE: Secondary malignancy is a major life-threatening complication facing patients afflicted with acquired immunodeficiency syndrome (AIDS). This study aimed to retrospectively review clinical features and treatment course of five patients with AIDS-associated non-Hodgkin lymphoma (A-NHL) in Jilin Tumor Hospital. METHODS: Five A-NHL patients were retrospectively and consecutively hospitalized at our oncological unit between January 2012 and June 2014. All patients received pre-emptive highly active antiretroviral therapy (HAART) and chemotherapy, and were subsequently followed up at the outpatient clinic...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Heng Fan, Jian-Hua Zhu, Xue-Qing Yao
OBJECTIVE: The co-stimulatory molecule B7-H3 plays an important role in prognosis of several malignancies. However, its prognostic value in clinic in patient with colorectal cancer (CRC) is still controversial. This meta-analysis evaluated the relationship between B7-H3 expression and the outcomes of CRC patients. METHODS: PubMed, Google Scholar, Embase, CNKI and Wanfang database were searched for the studies on the relationship between the expression of B7-H3 and prognosis of CRC patients...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Salman Y Guraya, Robert I Norman, Khalid I Khoshhal, Shaista Salman Guraya, Antonello Forgione
OBJECTIVES: Generally, academic promotions, job retention, job mobility, and professional development of a medical faculty members are judged primarily by the growth in publication outputs. Universities and research institutions are more likely to recruit and promote those academics carrying voluminous résumés with larger number of published articles. This review elaborates the causes and consequences of the pressure to publish and the ways and means to cope with this paradigm. METHODS: In 2015, database of Abstracts of Reviews of Effects, LISTA (EBSCO), Medline and Oxford University Library were searched for the English language full-text articles published during 2000-2015, by using MeSH terms "pressure to publish", "urge to publish", "research ethics", "plagiarism", "article retraction", "medical field"...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Shireen Qassim Bham, Farhan Saeed, Manzar Alam Shah
OBJECTIVE: To assess Knowledge, Attitude and Practices of mothers on ARI (Acute Respiratory Tract Infection) in children less than five years of age. METHODS: This cross-sectional survey was conducted in the Department of Pediatrics, Darul Sehat hospital from 1(st) December 2014 to 28(th) February 2015. Mothers(n=335) who were local residents, had at least one child below the age of five years and coming to the hospital for any medical problem along with accompanying women were included...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Behcet Sahin, Suphi Bulgurcu, Ilker Burak Arslan, Ibrahim Cukurova
OBJECTIVE: To assess the effects of tumor size, proximity to midline and invasion depth of oral cancer of the tongue (TC) on neck metastasis and recurrence. METHODS: In this retrospective observational study, was conducted through a chart review of the 11 male and 9 female patients who underwent surgeries with the diagnosis of tongue squamous cell carcinoma and at least one side neck dissection. We wanted to assess effects of tumor size, proximity to midline, and invasion depth of TC, according to the surgical specimens and pre-operative magnetic resonance imaging, on neck metastasis and recurrence between 2007 and 2014...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Qian Li, Ming-Hua Jiang, Jing Chen, Wei Liu, Bi-Qing Zhu, E-Mei Lu
OBJECTIVE: To identify the association between radiation dose volume and acute hematological toxicity (HT) in postoperative gynecological cancer patients receiving whole pelvic radiotherapy (RT) or intensity-modulated RT (IMRT), a principal component regression model was used to calculate HT. METHODS: Women (n=100) receiving with or without chemotherapy RT were retrospectively analyzed, 52 of whom received chemotherapy (paclitaxel and nedaplatin). The pelvis and lumbar vertebrae, defined as the prolong-pelvic bone marrow, were divided into the (1) combined ilium, ischium and pubis and the (2) lumbar vertebrae and the sacrum...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Syed Abid Hassan Naqvi, Sidra Malik, Syed Zulfiqaruddin, Syeda Birjees Anwar, Shahzad Nayyar
OBJECTIVE: To determine the etiology and severity of various forms of ocular war injuries in patients presenting at an Army Hospital in Pakistan. METHODS: This cross sectional study was conducted at the Department of Ophthalmology, Combined Military Hospital, Peshawar over four years period from June 2012 through March 2016, Two hundred ten consecutive soldiers who presented with ocular war injuries were included for analysis after taking written informed consent...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Nural Erzurum Alim, Gul Kiziltan
OBJECTIVE: To determine the risk factors of obesity and diet on breast cancer in Ankara, Turkey. METHODS: A case-controlled study was carried out on newly diagnosed 40 breast cancer patients [patient group (PC)] and 40 volunteer individuals [control group (CG)] with no diagnosis of cancer and history of cancer in the family with similar characteristics to the age and gender-matched patient group between March and July 2016. All the individuals were administered a questionnaire by face-to-face interview method...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Naila Yasmeen, Nauroz Fatima, Qamar-Ul-Islam
OBJECTIVE: To compare mean retinal nerve fiber layer (RNFL) thickness in patients having pseudo exfoliation (PXF) with normal age matched controls using spectral domain optical coherence tomography (SD-OCT). METHODS: This was a case control study conducted at Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi from 12 June 2013 to 12 January 2014. Seventy eyes (Group A - 35 patients with PXF and Group B - 35 healthy age matched subjects) of more than 40 years of age were included in the study...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Yasir Mehmood, Farhan Khashim Al-Swailmi, Shehab Ahmed Al-Enazi
OBJECTIVES: To determine the frequency of obesity disorders and their co-morbidities in medical students. METHODS: This cross-sectional study was conducted in Faculty of Medicine, Northern Border University, Ar'ar, Saudi Arabia. All medical students who consented to participate were included in the study. Their relevant information was recorded on a structured proforma. Weight and height of the participants were measured using calibrated manual weighing scale and Body mass index (BMI) was calculated...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Rabia Arshad, Muhammad Adnan Kanpurwala, Nasim Karim, Jahan Ara Hassan
OBJECTIVE: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM). METHODS: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Yulong Tao, Chengwu Tang, Wenming Feng, Ying Bao, Hongbin Yu
OBJECTIVE: To compare the efficacy and safety of early nasogastric enteral nutrition (EN) with total parenteral nutrition (TPN) in patients with severe acute pancreatitis (SAP). METHODS: From July 2008 to July 2014,185 patients with SAP admitted to our centre were enrolled in this retrospective study. They were divided into EN group (n=89) and TPN group (n=96) based on the nutrition support modes. Patients in EN group received nasogastric EN support, while patients in TPN group received TPN support within 72 hours of disease onset...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Sonia Salamat, Hasan Ejaz, Aizza Zafar, Humera Javed
OBJECTIVE: The objective of this study was to determine the occurrence and antimicrobial profile of AmpC β-lactamase producing bacteria. METHODS: The study was conducted at The Children's Hospital and The Institute of Child Health Lahore, Pakistan, during September 2011 to June 2012. A total number of 1,914 blood samples of suspected neonatal septicemia were processed. Isolates were identified using Gram's staining, API 20E and API 20NE tests. Gram negative isolates were screened for AmpC β-lactamase production against ceftazidime, cefotaxime and cefoxitin resistance and confirmed by inhibitor based method...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Songul Binay, Peri Arbak, Alp Alper Safak, Ege Gulec Balbay, Cahit Bilgin, Naciye Karatas
OBJECTIVE: To determine whether the workers' periodic chest x-ray screening techniques in accordance with the quality standards is the responsibility of physicians. Evaluation of differences of interpretations by physicians in different levels of education and the importance of standardization of interpretation. METHODS: Previously taken chest radiographs of 400 workers who are working in a factory producing the glass run channels were evaluated according to technical and quality standards by three observers (pulmonologist, radiologist, pulmonologist assistant)...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Saira Afzal, Azka Naeem, Unaiza Shahid, Wajiha Noor Syed, Urva Khan, Nayyar Misal Zaidi
OBJECTIVE: To determine the association of Lady Health Worker's role with immunization of children in Pakistan. METHODS: Secondary analysis was conducted on data obtained from Pakistan's Demographic and Health Survey. Children who did not receive all doses of vaccines were considered incompletely immunized or vice versa. The association between determinants was assessed by simple and multivariable binary logistic regression. RESULTS: The mothers and fathers had a mean age of 32...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Shahid Iqbal, Syed Z A Zaidi, Ibraheem H Motabi, Nawal Faiez Alshehry, Mubarak S AlGhamdi, Imran Khan Tailor
OBJECTIVE: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease. The primary aim was overall response rate (ORR) assessment in the treated patients. METHODS: This retrospective study included 24 patients treated during 2006-2015. TTP patients with microangiopathic hemolysis (MAHA) and thrombocytopenia were included. We analyzed clinical features, laboratory characteristics and treatment outcomes of 24 TTP patients treated at our tertiary care center (KFMC)...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Ambreen Usmani, Quratulain Omaeer
OBJECTIVE: To explore the mentoring program on a subset of Pakistani medical students in a private medical college. METHOD: Total students targeted were 300 MBBS students of 1(st) Year (group B), 2(nd) Year (group C) and 3(rd) Year (group D), of these 256 students filled the self-reported questionnaire. The questionnaire was based on Likert Scale. The statements in the questionnaire are designed in a positive manner so that if the students agree to them the level of satisfaction with the mentoring program was considered significantly good...
November 2016: Pakistan Journal of Medical Sciences Quarterly
Hongli Wu, Lin Chen, Yuefeng Sun, Chao Meng, Wei Hou
OBJECTIVE: To determine the role of serum procalcitonin (PCT) and C-reactive protein (CRP) in predicting spontaneous bacterial peritonitis (SBP) in patients with advanced liver cirrhosis. METHODS: A total of 88 patients with advanced liver cirrhosis were enrolled for this study, which included 40 cases with SBP and 48 cases with CNNA. Bacterial cultures, ascitic fluid (AF) leukocyte, C-reactive protein (CRP) and serum PCT measurements were carried out prior to the use of antibiotics...
November 2016: Pakistan Journal of Medical Sciences Quarterly
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