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Journal of Ginseng Research

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https://www.readbyqxmd.com/read/29719472/biogf1k-a-compound-k-rich-fraction-of-ginseng-plays-an-antiinflammatory-role-by-targeting-an-activator-protein-1-signaling-pathway-in-raw264-7-macrophage-like-cells
#1
Eunji Kim, Young-Su Yi, Young-Jin Son, Sang Yun Han, Dong Hyun Kim, Gibaeg Nam, Mohammad Amjad Hossain, Jong-Hoon Kim, Junseong Park, Jae Youl Cho
No abstract text is available yet for this article.
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719471/synergistic-effect-of-maclurin-on-ginsenoside-compound-k-induced-inhibition-of-the-transcriptional-expression-of-matrix-metalloproteinase-1-in-hacat-human-keratinocyte-cells
#2
https://www.readbyqxmd.com/read/29719470/ginsenoside-rg5-prevents-apoptosis-by-modulating-heme-oxygenase-1-nuclear-factor-e2-related-factor-2-signaling-and-alters-the-expression-of-cognitive-impairment-associated-genes-in-thermal-stress-exposed-ht22-cells
#3
Seo-Yun Choi, Kui-Jin Kim, Ji-Hyeon Song, Boo-Yong Lee
Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719469/the-skin-protective-effects-of-compound-k-a-metabolite-of-ginsenoside-rb1-from-panax-ginseng
#4
Eunji Kim, Donghyun Kim, Sulgi Yoo, Yo Han Hong, Sang Yun Han, Seonggu Jeong, Deok Jeong, Jong-Hoon Kim, Jae Youl Cho, Junseong Park
Background: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng . There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient. Methods: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719468/study-on-the-grading-standard-of-panax-notoginseng-seedlings
#5
Lijuan Chen, Ye Yang, Jin Ge, Xiuming Cui, Yin Xiong
Background: The quality differences in seedlings of medicinal herbs often affect the quality of medicinal parts. The establishment of the grading standard of Panax notoginseng seedlings is significant for the stable quality of medicinal parts of P. notoginseng. Methods: To establish the grading standard of P. notoginseng seedlings, a total of 36,000 P. notoginseng seedlings were collected from 30 producing areas, of which the fresh weight, root length, root diameter, bud length, bud diameter, and rootlet number were measured...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719467/new-metabolites-from-the-biotransformation-of-ginsenoside-rb1-by-paecilomyces-bainier-sp-229-and-activities-in-inducing-osteogenic-differentiation-by-wnt-%C3%AE-catenin-signaling-activation
#6
Wei Zhou, Hai Huang, Haiyan Zhu, Pei Zhou, Xunlong Shi
Background: Ginseng is a well-known traditional Chinese medicine that has been widely used in a range of therapeutic and healthcare applications in East Asian countries. Microbial transformation is regarded as an effective and useful technology in modification of nature products for finding new chemical derivatives with potent bioactivities. In this study, three minor derivatives of ginsenoside compound K were isolated and the inducing effects in the Wingless-type MMTV integration site (Wnt) signaling pathway were also investigated...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719466/effect-of-high-dose-ginsenoside-complex-ug0712-supplementation-on-physical-performance-of-healthy-adults-during-a-12-week-supervised-exercise-program-a-randomized-placebo-controlled-clinical-trial
#7
Eon Sook Lee, Yun Jun Yang, Jun Hyung Lee, Yeong Sook Yoon
Background: Ginseng has been used as an ergogenic agent, although evidence for its effectiveness is weak. A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effect of a ginsenoside complex (UG0712) on changes in exercise performance. Methods: Sedentary individuals ( n   =  117) were randomly assigned into one of three groups: low-dose ginsenoside supplementation (100 mg/d, n   =  39), high-dose ginsenoside supplementation (500 mg/d, n   =  39), or a placebo group (500 mg/d, n   =  39)...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719465/antinociceptive-and-anti-inflammatory-effects-of-ginsenoside-rf-in-a-rat-model-of-incisional-pain
#8
Min Kyoung Kim, Hyun Kang, Chong Wha Baek, Yong Hun Jung, Young Cheol Woo, Geun Joo Choi, Hwa Yong Shin, Kyung Soo Kim
Background: Ginseng saponin has long been used as a traditional Asian medicine and is known to be effective in treating various kinds of pain. Ginsenoside Rf is one of the biologically active saponins found in ginseng. We evaluated ginsenoside Rf's antinociceptive and anti-inflammatory effects, and its mechanism of action on adrenergic and serotonergic receptors, in an incisional pain model. Methods: Mechanical hyperalgesia was induced via plantar incision in rats followed by intraperitoneal administration of increasing doses of ginsenoside Rf (vehicle, 0...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719464/effect-of-azoxystrobin-fungicide-on-the-physiological-and-biochemical-indices-and-ginsenoside-contents-of-ginseng-leaves
#9
Shuang Liang, Xuanwei Xu, Zhongbin Lu
Background: The impact of fungicide azoxystrobin, applied as foliar spray, on the physiological and biochemical indices and ginsenoside contents of ginseng was studied in ginseng ( Panax ginseng Mey. cv. "Ermaya") under natural environmental conditions. Different concentrations of 25% azoxystrobin SC (150 g a.i./ha and 225 g a.i./ha) on ginseng plants were sprayed three times, and the changes in physiological and biochemical indices and ginsenoside contents of ginseng leaves were tested...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719463/compound-k-induced-apoptosis-via-endoplasmic-reticulum-ca-2-release-through-ryanodine-receptor-in-human-lung-cancer-cells
#10
Dong-Hyun Shin, Dong-Gyu Leem, Ji-Sun Shin, Joo-Il Kim, Kyung-Tack Kim, Sang Yoon Choi, Myung-Hee Lee, Jung-Hye Choi, Kyung-Tae Lee
Background: Extended endoplasmic reticulum (ER) stress may initiate apoptotic pathways in cancer cells, and ER stress has been reported to possibly increase tumor death in cancer therapy. We previously reported that caspase-8 played an important role in compound K-induced apoptosis via activation of caspase-3 directly or indirectly through Bid cleavage, cytochrome c release, and caspase-9 activation in HL-60 human leukemia cells. The mechanisms leading to apoptosis in A549 and SK-MES-1 human lung cancer cells and the role of ER stress have not yet been understood...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719462/genetic-variability-associations-and-path-analysis-of-chemical-and-morphological-traits-in-indian-ginseng-withania-somnifera-l-dunal-for-selection-of-higher-yielding-genotypes
#11
Abhilasha Srivastava, Anil K Gupta, Karuna Shanker, Madan M Gupta, Ritu Mishra, Raj K Lal
Background: The study was carried out to assess the genetic variability present in ashwagandha and to examine the nature of associations of various traits to the root yield of the plant. Methods: Fifty-three diverse genetic stocks of ashwagandha ( Withania somnifera ) were evaluated for 14 quantitative characteristics. Analysis of variance, correlation, and path coefficient analysis were performed using the mean data of 2 years. Results: Analysis of variance revealed that the genotypes differed significantly for all characteristics studied...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719461/qualitative-and-quantitative-analysis-of-the-saponins-in-panax-notoginseng-leaves-using-ultra-performance-liquid-chromatography-coupled-with-time-of-flight-tandem-mass-spectrometry-and-high-performance-liquid-chromatography-coupled-with-uv-detector
#12
Fang Liu, Ni Ma, Chengwei He, Yuanjia Hu, Peng Li, Meiwan Chen, Huanxing Su, Jian-Bo Wan
Background: Panax notoginseng leaves (PNL) exhibit extensive activities, but few analytical methods have been established to exclusively determine the dammarane triterpene saponins in PNL. Methods: Ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC/Q-TOF MS) and HPLC-UV methods were developed for the qualitative and quantitative analysis of ginsenosides in PNL, respectively. Results: Extraction conditions, including solvents and extraction methods, were optimized, which showed that ginsenosides Rc and Rb3, the main components of PNL, are transformed to notoginsenosides Fe and Fd, respectively, in the presence of water, by removing a glucose residue from position C-3 via possible enzymatic hydrolysis...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719460/korean-red-ginseng-exhibits-no-significant-adverse-effect-on-disease-activity-in-patients-with-rheumatoid-arthritis-a-randomized-double-blind-crossover-study
#13
Soo-Kyung Cho, Dam Kim, Dasomi Yoo, Eun Jin Jang, Jae-Bum Jun, Yoon-Kyoung Sung
Background: Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the impact of Korean Red Ginseng (KRG) on disease activity and safety in RA patients. Methods: A total of 80 female RA patients were randomly assigned to either the KRG (2 g/d, n  = 40) treatment or placebo ( n  = 40) groups for 8 wk, followed by crossover to the other treatment group for an additional 8 wk...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719459/anticancer-activity-and-potential-mechanisms-of-1c-a-ginseng-saponin-derivative-on-prostate-cancer-cells
#14
Xu De Wang, Guang Yue Su, Chen Zhao, Fan Zhi Qu, Peng Wang, Yu Qing Zhao
Background: AD-2 (20( R )-dammarane-3b, 12b, 20, 25-tetrol; 25-OH-PPD) is a ginsenoside and isolated from Panax ginseng , showing anticancer activity against extensive human cancer cell lines. In this study, effects and mechanisms of 1C ((20 R )-3b- O -(L-alanyl)-dammarane-12b, 20, 25-triol), a modified version of AD-2, were evaluated for its development as a novel anticancer drug. Methods: MTT assay was performed to evaluate cell cytotoxic activity. Cell cycle and levels of reactive oxygen species (ROS) were determined using flow cytometry analysis...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29719458/molecular-signaling-of-ginsenosides-rb1-rg1-and-rg3-and-their-mode-of-actions
#15
REVIEW
Padmanaban Mohanan, Sathiyamoorthy Subramaniyam, Ramya Mathiyalagan, Deok-Chun Yang
Ginseng has gained its popularity as an adaptogen since ancient days because of its triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and classified as protopanaxatriol and protopanaxadiol saponins based on their glycosylation patterns. They play many protective roles in humans and are under intense research as various groups continue to study their efficacy at the molecular level in various disorders. Ginsenosides Rb1 and Rg1 are the most abundant ginsenosides present in ginseng roots, and they confer the pharmacological properties of the plant, whereas ginsenoside Rg3 is abundantly present in Korean Red Ginseng preparation, which is highly known for its anticancer effects...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348730/black-ginseng-activates-akt-signaling-thereby-enhancing-myoblast-differentiation-and-myotube-growth
#16
Soo-Yeon Lee, Ga-Yeon Go, Tuan Anh Vuong, Jee Won Kim, Sullim Lee, Ayoung Jo, Jun Min An, Su-Nam Kim, Dong-Wan Seo, Jin-Seok Kim, Yong Kee Kim, Jong-Sun Kang, Sang-Jin Lee, Gyu-Un Bae
Background: Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Methods: BG-treated C2C12 myoblasts were differentiated, followed by immunoblotting for myogenic regulators, immunostaining for a muscle marker, myosin heavy chain or immunoprecipitation analysis for myogenic transcription factors...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348729/-panax-ginseng-exerts-antidepressant-like-effects-by-suppressing-neuroinflammatory-response-and-upregulating-nuclear-factor-erythroid-2-related-factor-2-signaling-in-the-amygdala
#17
Jong Hee Choi, Min Jung Lee, Minhee Jang, Hak-Jae Kim, Sanghyun Lee, Sang Won Lee, Young Ock Kim, Ik-Hyun Cho
Background: Depression is one of the most commonly diagnosed neuropsychiatric diseases, but the underlying mechanism and medicine are not well-known. Although Panax ginseng has been reported to exert protective effects in various neurological studies, little information is available regarding its antidepressant effects. Methods: Here, we examined the antidepressant effect and underlying mechanism of P. ginseng extract (PGE) in a chronic restraint stress (CRS)-induced depression model in mice...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348728/systems-level-mechanisms-of-action-of-panax-ginseng-a-network-pharmacological-approach
#18
REVIEW
Sa-Yoon Park, Ji-Hun Park, Hyo-Su Kim, Choong-Yeol Lee, Hae-Jeung Lee, Ki Sung Kang, Chang-Eop Kim
Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng , it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348727/efficacy-and-safety-of-panax-ginseng-berry-extract-on-glycemic-control-a-12-wk-randomized-double-blind-and-placebo-controlled-clinical-trial
#19
Han Seok Choi, Sunmi Kim, Min Jung Kim, Myung-Sunny Kim, Juewon Kim, Chan-Woong Park, Daebang Seo, Song Seok Shin, Sang Woo Oh
Background: Antihyperglycemic effects of Panax ginseng berry have never been explored in humans. The aims of this study were to assess the efficacy and safety of a 12-wk treatment with ginseng berry extract in participants with a fasting glucose level between 100 mg/dL and 140 mg/dL. Methods: This study was a 12-wk, randomized, double-blind, placebo-controlled clinical trial. A total of 72 participants were randomly allocated to two groups of either ginseng berry extract or placebo, and 63 participants completed the study...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348726/photoaging-protective-effects-of-biogf1k-a-compound-k-rich-fraction-prepared-from-panax-ginseng
#20
Yo Han Hong, Donghyun Kim, Gibaeg Nam, Sulgi Yoo, Sang Yun Han, Seong-Gu Jeong, Eunji Kim, Deok Jeong, Keejung Yoon, Sunggyu Kim, Junseong Park, Jae Youl Cho
Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events. Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry...
January 2018: Journal of Ginseng Research
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