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Dominik Samotij, Joanna Maj, Adam Reich
A number of rheumatic disorders may appear as paraneoplastic syndromes, the most common being dermatomyositis or polymyositis. Systemic sclerosis is associated with a slightly increased risk of cancer, although its direct association with malignancies is controversial. We describe a case of a 57-year-old male with rectal adenocarcinoma and systemic sclerosis. Close temporal relationship between the initial presentation and parallel course of both conditions, as well as atypically rapid progression of systemic sclerosis symptoms, were observed in the reported case...
2018: Reumatologia
Iryna Kniazkova, Larysa Shapovalova, Maryna Bogun
The presented case report concerns a 62-year-old male patient who was admitted to the rheumatology department with a fever, shoulder and hip joint pain, significant limitation of movement in these joints and general weakness. Laboratory test revealed increase of inflammatory parameters, as ESR and C-reactive protein, rheumatoid factor and ACPA antibodies were absent. In the course of diagnostics, infections and cancer were excluded. The patient met the classification criteria for polymyalgia rheumatica. Polymyalgia rheumatica is not a rare disease, but the number of elderly people in the world continues to increase, and we can assume that the prevalence of this disease will increase in the coming years...
2018: Reumatologia
Marek Marcin Chojnowski, Maria Teresa Płazińska, Marek Sławomir Chojnowski, Leszek Królicki
Radionuclide synovectomy (RSV) is a form of minimally invasive treatment of persistent joint inflammation. The procedure has a high safety profile and the occurrence of serious adverse events, such as full-thickness skin radiation necrosis, is rare. Less severe radiation events, while more common, are usually benign and self-limiting. We present two cases of low-grade beta burns that developed after RSV, despite proper injection technique. The potential long-term risk of such exposure is also discussed, with reference to historical radiation incidents...
2018: Reumatologia
Justyna Kołodziejska, Michał Kołodziejczyk
Diclofenac, a phenylacetic acid derivative, is a drug demonstrating high efficacy after oral administration in the treatment of pain and physical disability in rheumatic diseases. In view of the adverse effects associated with using diclofenac, it is necessary to consider all known drug safety information before the drug is selected for therapy and the dosage regimen is set for individual patients. Selecting an oral dosage form with specific properties determined by excipients is a method to improve the availability of the drug substance and, at the same time, minimize adverse drug reactions...
2018: Reumatologia
Ewa Haładyj, Mariusz Sikora, Anna Felis-Giemza, Marzena Olesińska
Antimalarial drugs (AD) are a group of widespread therapeutic agents in multiple rheumatic indications. Although the effect of AD is mild and extended in time, low toxicity is their appreciated value. This paper describes the current state of knowledge on the mechanism of action, use, toxicity and pleiotropic effects of AD in the pharmacotherapy of autoimmune diseases.
2018: Reumatologia
Richard O Akintayo, Gbenga J Odunlami, Opeyemi F Bamidele, Eniola P Fabiyi, Foluke C Akintayo, Oluwakemi V Bamidele, Ibukunoluwa A Dedeke, Toluwalashe T Osagie, Adekunle A Ibisola
Objectives: To assess the levels of state and trait anxiety and determine their relationships with perceived social support among Nigerian patients with rheumatoid arthritis (RA). Material and methods: A cross-sectional study of 50 patients satisfying the 2010 American College of Rheumatology/European League against Rheumatism Classification Criteria for RA was conducted. Anxiety was assessed using the Spielberger State-Trait Anxiety Inventory (STAI), perceived social support by the Interpersonal Support Evaluation List (ISEL), health-related quality of life (HRQoL) by the Medical Outcome Study 36-Item Short Form Health Survey (SF-36) and disability by the Health Assessment Questionnaire-Disability Index (HAQ-DI)...
2018: Reumatologia
Agnieszka Zygmunt, Joanna Lipińska, Małgorzata Biernacka-Zielińska, Ewa Lipiec, Anna Niwald, Elżbieta Smolewska
Objectives: Uveitis and juvenile idiopathic arthritis (JIA) relatively often coexist. Inflammatory changes in the anterior segment of the eye are the most common extra-articular symptom in children with JIA, and JIA is, in turn, the main systemic cause of anterior uveitis in children. The aim of our study was to compare the course of anterior uveitis accompanying JIA and isolated uveitis. Material and methods: We analyzed 25 children with JIA and uveitis (group I) and 28 children with isolated uveitis (group II)...
2018: Reumatologia
Anna Kotulska, Eugeniusz J Kucharz, Piotr Wiland, Marzena Olesińska, Anna Felis-Giemza, Magdalena Kopeć-Mędrek, Aleksandra Zoń-Giebel, Wojciech Romanowski, Lucyna Szymczak-Bartz, Małgorzata Tłustochowicz, Jolanta Lewandowicz, Joanna Kowalska-Majka, Jolanta Bucka, Maria Majdan, Zofia Kiełbik, Mariusz Korkosz, Aneta Bielińska, Piotr Leszczyński, Katarzyna Pawlak-Buś, Mariusz J Puszczewicz, Dominik Majewski, Katarzyna Smolik, Teresa Migas-Kukla, Małgorzata Sochocka-Bykowska, Maria Szarecka, Bernadeta Luberda, Małgorzata Falenta-Hitnarowicz, Jadwiga Świkszcz-Gniadek, Wanda Lepiarz-Rusek, Grzegorz Rozwadowski, Barbara Chara, Jerzy Zajdel, Zbigniew Zdrojewski, Maria Maciejowska-Roge, Irena Rosmus-Kuczia
Objectives: Biologics are medications widely applied in the management of inflammatory rheumatic diseases. The drugs were found to be effective but their application is associated with some disadvantages. Medication with biologics is relatively expensive, and in Poland, it is carried out in specialized centers. The study was designed to evaluate various aspects of satisfaction and dissatisfaction of Polish patients treated with biologics. Material and methods: An anonymous questionnaire was distributed in 23 Polish rheumatological centers involved in the treatment; 1212 returned questionnaires were used for analysis...
2018: Reumatologia
Ciro Manzo, Maria Natale, Enea Traini
Objectives: To evaluate in a primary care setting the favoring and confounding factors for the diagnosis of polymyalgia rheumatica (PMR). Material and methods: Among 303 patients consecutively referred by their general practitioners (GPs) to our rheumatologic outpatient clinic, we identified three groups: group A - patients with confirmed diagnosis of PMR, group B - patients with unconfirmed diagnosis, group C - patients with unrecognized PMR. All the diagnostic confounding and favoring factors were discussed with GPs using an e-mail questionnaire...
2018: Reumatologia
Alfredo Tarantino, Justyna Paulina Jablonska, Paola D'Aprile
No abstract text is available yet for this article.
2018: Reumatologia
Jolanta Grygielska, Filip Raciborski, Anna Kłak, Jakub Owoc
Nutrition habits and diet may influence disease development and course. There are no specific recommendations related to rheumatic diseases for a diet that would facilitate treatment. However, some research results suggest that various nutrients may affect the health of patients, especially in the case of inflammatory rheumatic disease such as rheumatoid arthritis (RA). Scientists have been trying to find a relation between inflammatory rheumatic diseases and diet but have never come up with any firm conclusions that would help in determining the model of a diet for such patients...
2018: Reumatologia
Monika Ostrowska, Włodzimierz Maśliński, Monika Prochorec-Sobieszek, Michał Nieciecki, Iwona Sudoł-Szopińska
Rheumatoid arthritis (RA), which is a chronic inflammatory disease with a multifactorial aetiology, leads to partial or permanent disability in the majority of patients. It is characterised by persistent synovitis and formation of pannus, i.e. invasive synovial tissue, which ultimately leads to destruction of the cartilage, subchondral bone, and soft tissues of the affected joint. Moreover, inflammatory infiltrates in the subchondral bone, which can lead to inflammatory cysts and later erosions, play an important role in the pathogenesis of RA...
2018: Reumatologia
Barbara Nieradko-Iwanicka
Angiotensin receptor blockers or sartans are used to treat arterial hypertension. Hyperuricemia and arterial hypertension often coexist in patients with metabolic syndrome. Also hyperuricemia is correlated with an increased risk of cardiovascular disease and death. There are data suggesting that lowering serum urate may assist in control of arterial hypertension and use of certain drugs for arterial hypertension may reduce the serum uric acid level. The Polish Society of Arterial Hypertension recommends losartan for treatment of arterial hypertension in patients with coexisting hyperuricemia...
2018: Reumatologia
Joanna Perzyńska-Mazan, Maria Maślińska, Robert Gasik
Primary Sjögren's syndrome (pSS) is an autoimmune connective tissue disease affecting the exocrine glands, leading to damage of their structure and impairment of their function. In the course of pSS the internal organs may be involved and the symptoms may concern any system. Neurological disorders are one of the most common extraglandular manifestations of pSS. Available literature data estimate the prevalence of neurological symptoms as about 8.5-70% of patients diagnosed with pSS. The most common neurological complication of pSS is peripheral neuropathy, and in particular sensory polyneuropathy...
2018: Reumatologia
Narumol Chaosuwannakit, Pattarapong Makarawate
Objectives: To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis. Material and methods: Twenty-six consecutive patients with systemic sclerosis underwent cardiac MRI to determine morphological, functional, perfusion at rest, and delayed enhancement abnormalities. Results: At least one abnormality on cardiac MRI was observed in 19/26 (73%) patients. Increased myocardial signal intensity in T2 was observed in 10 patients (38...
2018: Reumatologia
Harpreet Singh, Saroj Bala, Deepak Jain, Ruchi Jagota, Rekha Mathur
Objectives: Disease-modifying anti-rheumatic drugs (DMARDs) are conventionally used in rheumatoid arthritis (RA). The role of spironolactone as add on therapy to DMARDs in RA patients was evaluated. Material and methods: A total of 100 patients with rheumatoid arthritis diagnosed as per 1987 criteria having evidence of active disease despite ongoing DMARD therapy were enrolled in this study. Patients were assigned randomly to two groups. Group I ( n = 50) patients were treated with 50 mg/day of spironolactone along with their maintenance DMARD and NSAID therapy...
2018: Reumatologia
Jarosław Amarowicz, Edward Czerwiński, Anna Kumorek, Maja Warzecha, Małgorzata Berwecka, Didier Hans
Objectives: The aim of our study was to determine a possible correlation between vertebral fractures (indicated by VFA - vertebral fracture assessment), TBS (trabecular bone score) and muscle strength (measured by means of handgrip strength test results) in a group of postmenopausal women. Material and methods: The study was conducted between 2014 and 2015 in a group of patients of Krakow Medical Centre (KMC). Women who participated in the study were referred to KMC by an attending physician for suspected vertebral fracture...
2018: Reumatologia
Barbara Stypińska, Marzena Olesińska, Andrzej Pawlik, Agnieszka Paradowska-Gorycka
Objectives: Rheumatoid arthritis (RA) is the most common systemic inflammatory disease and is of unknown etiology. The altered balance between immunosuppressive and inflammatory T cell subpopulations exerts a huge impact on RA pathogenesis. The STAT3 protein regulates genes involved in the immune responses. It regulates maturation of T and B cells. Its abnormal activity is significantly associated with autoimmune diseases and cancer development. We aimed to evaluate the contribution of three potentially functional single nucleotide polymorphisms (SNPs) within the STAT3 gene to susceptibility and severity of RA in the Polish population...
2018: Reumatologia
Saeedeh Shenavandeh, Keramat Allah Jahanshahi, Elham Aflaki, Alireza Tavassoli
Objectives: Idiopathic uveitis is the most common form of uveitis in most countries. Uveitis affects about 40-80% of patients with Behçet's disease (BD). Class I, HLA-B5, and its subclass B51 allele have the strongest association with BD, but its role in idiopathic uveitis is unclear. The aim of this study was to determine the frequency of HLA-B5, HLA-B51 and HLA-B27 in patients with idiopathic uveitis, BD and the control group. Material and methods: Forty-eight patients with idiopathic uveitis, 62 patients with BD, and 49 control subjects were compared...
2018: Reumatologia
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