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Reumatologia

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https://www.readbyqxmd.com/read/29056777/relapsing-granulomatosis-with-polyangiitis-with-severe-lung-and-upper-respiratory-tract-involvement-successfully-treated-with-rituximab
#1
Anna Masiak, Zbigniew Zdrojewski
Granulomatosis with polyangiitis (GPA) is a chronic, relapsing, primary systemic small vessel vasculitis associated with anti-neutrophil cytoplasmic antibodies. The disease is characterised by the involvement of various organs. The relapse rate rises from about 20% at 12 months to about 60% at 5 years. The combination of glucocorticoids and cyclophosphamide remains the standard therapy for patients with generalised GPA; nevertheless, some patients do not respond satisfactorily to this treatment. According to EULAR-EDTA recommendations for the management of ANCA-associated vasculitis, RTX should be considered for remission-induction of new-onset as well as major relapse of organ-threatening or life-threatening GPA...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056776/cervical-spine-instability-in-the-course-of-rheumatoid-arthritis-imaging-methods
#2
REVIEW
Małgorzata Mańczak, Robert Gasik
Cervical spine is affected in more than a half of patients with rheumatoid arthritis (RA). Depending on the degree of damage to the individual joints and ligaments RA-related cervical spine instability takes the form of atlanto-axial subluxation, subaxial subluxation or cranial settling. In the advanced cases spinal stenosis can occur as well as spinal cord injuries with typical neurological symptoms. The identification of patients with cervical spine instability before the occurrence of neurological complications still constitutes a diagnostic challenge...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056775/complex-diagnostics-of-common-conditions-of-the-motor-organ-of-the-developmental-age
#3
REVIEW
Iwona Słowińska
Some muscular and osteoarticular diseases pose serious diagnostic problems, e.g. subsequent recurrent or persistent conditions of isolated pain in the extremities, most frequently - in the lower extremities, especially knee joints, and isolated pain in the back, usually in the lumbosacral spine. They are often accompanied by gait abnormalities. The paper herein presents a complex differential diagnosis of these conditions, the presented diseases that can cause them, and the role of the family doctor, paediatrician, orthopaedist, and rheumatologist in the diagnosis...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056774/glucocorticoid-management-in-rheumatoid-arthritis-morning-or-night-low-dose
#4
REVIEW
Sabrina Paolino, Maurizio Cutolo, Carmen Pizzorni
Morning symptoms of rheumatoid arthritis (RA) are linked to circadian increase of night inflammation, supported by inadequate cortisol secretion in active disease. Therefore, exogenous glucocorticoid administration in RA is recommended by EULAR and ACR from the beginning of the diagnosis, since may partially act like a "replacement therapy". In addition, the prevention/treatment of the night up-regulation of the immune/inflammatory reaction has been shown more effective when exogenous glucocorticoid administration is managed with a night-time-release formulation...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056773/investigating-mental-health-in-patients-with-osteoarthritis-and-its-relationship-with-some-clinical-and-demographic-factors
#5
Masoumeh Nazarinasab, Azim Motamedfar, Azin Eskandari Moqadam
OBJECTIVE: The reduction in the level of mental health, particularly depression is associated with outcome of treatment in patients with osteoarthritis (OA). There is no broader research into mental health or mental health care for OA patients. The purpose of the present study was to determine mental health and its relationship with some clinical and demographic factors among patients with OA. MATERIAL AND METHODS: 94 patients with osteoarthritis were included in presented study...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056772/the-role-of-ultrasonography-in-monitoring-long-standing-rheumatoid-arthritis-a-pilot-study
#6
Sławomir Jeka, Marta Dura, Paweł Żuchowski, Beata Zwierko, Rafał Wojciechowski
OBJECTIVE: Rheumatoid arthritis (RA) is a condition that poses many diagnostic problems. As a result, it is often diagnosed too late, which makes effective treatment more difficult. The course of the disease is chronic, and it causes irreversible changes in the musculoskeletal system, as well as bone destruction, and this in turn impairs the proper monitoring of the treatment. Therefore, in order to assess the treatment's efficacy, as well as a clinical examination of the patient and laboratory tests, diagnostic imaging is being used more frequently in routine practice...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056771/diagnostic-delays-in-rheumatic-diseases-with-associated-arthritis
#7
Filip Raciborski, Anna Kłak, Brygida Kwiatkowska, Bogdan Batko, Małgorzata Sochocka-Bykowska, Aleksandra Zoń-Giebel, Zbigniew Gola, Zbigniew Guzera, Maria Maślińska
OBJECTIVE: The objective of this study was to determine the length of delay in diagnosis of inflammatory rheumatic diseases, and to indicate the main factors responsible for such delays. MATERIAL AND METHODS: A retrospective multi-centre questionnaire survey carried out among 197 patients with diagnosed inflammatory rheumatic diseases or undergoing the diagnostic process. RESULTS: The most common early symptoms of inflammatory rheumatic disease included joint pain (94%), joint swelling (78%), morning joint stiffness (77%), fatigue (76%), and sleep disturbed by joint pain (74%)...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056770/assessment-of-hospitalization-and-mortality-of-scleroderma-in-patients-a-thirteen-year-study
#8
Saeedeh Shenavandeh, Razieh Naseri
OBJECTIVE: Systemic sclerosis (SSc) is an uncommon non-hereditary sporadic disease that increases the risk of premature death, especially in diffuse type. We determined the prevalence of SSc in the last 13 years in our rheumatologic hospitals as a referral center for southern Iranian patients, the causes of hospitalization, the average length of stay (LOS), the mortality rate, and the reason for their mortality. MATERIAL AND METHODS: A cross-sectional study was performed in Shiraz University of Medical Sciences, Iran...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056769/disease-activity-in-axial-spondyloarthritis-after-discontinuation-of-tnf-inhibitors-therapy
#9
Agata Sebastian, Patryk Wojtala, Łukasz Lubiński, Małgorzata Mimier, Arkadiusz Chlebicki, Piotr Wiland
OBJECTIVE: Use of tumour necrosis factor inhibitors (TNFi) has proved to be an important step forward in the treatment of axial spondyloarthritis (axSpA), but the duration of the therapy as well as the management in case of low disease activity (LDA) or remission are not clearly established. Currently, the identification of potential predictors associated with the treatment discontinuation is the basic purpose of many clinical studies. The aim of this study was to analyze the influence of the discontinuation of TNFi therapy on the disease activity in patients with low disease activity...
2017: Reumatologia
https://www.readbyqxmd.com/read/29056768/signet-ring-cell-adenoma-of-the-thyroid-and-rheumatoid-arthritis-incidental-association-or-methotrexate-related-change
#10
EDITORIAL
Adriana Handra-Luca
No abstract text is available yet for this article.
2017: Reumatologia
https://www.readbyqxmd.com/read/28769140/aortic-aneurysm-in-a-patient-with-syphilis-related-spinal-pain-and-paraplegia
#11
Daniel Brito de Araujo, Danise Senna Oliveira, Rodrigo Kraft Rovere, Umberto Lopes de Oliveira Filho
The tertiary stage of syphilis is nowadays extremely rare, showing predilection for the cardiovascular and nervous systems. A 57-year-old Caucasian man sought medical assistance due to back pain that evolved to paraplegia of the lower limbs. A thoracic CT scan demonstrated an important aneurysmatic lesion of the descending thoracic aorta causing erosion of the vertebral bodies and VDRL and FTA-abs positivity. Although rare, syphilitic aortitis, the hallmark of cardiovascular syphilis, should be considered in the differential diagnosis in patients with thoracic aneurysm when in the absence of classic risk factors for atherosclerosis, especially in cases that progress with erosion of vertebral bodies...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769139/three-atypical-manifestations-of-granulomatosis-with-polyangiitis-lateral-medullary-syndrome-anterior-cheek-mass-and-melting-scleritis-of-eye
#12
Saeedeh Shenavandeh, Peyman Petramfar
Granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis) is a vasculitis with various organ involvement. There have been a few cases of CNS stroke and rare cases of lateral medullary infarction (LMI) as a manifestation of GPA. Also there have been reports of sinuses, nose and laryngeal masses mistakenly referred as carcinomas and subsequently GPA was diagnosed in their pathological reports. Another severe fulminant manifestation can be necrotizing scleritis leading to perforation of sclera. Therefore, here we present some rare and fulminant manifestations of GPA in 3 separate cases for further emphasis of the unusual manifestations of GPA that should always be kept in mind...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769138/retroperitoneal-fibrosis-a-report-of-five-cases
#13
Marta Runowska, Dominik Majewski, Mariusz Puszczewicz
Retroperitoneal fibrosis (RPF) is a rare disease, characterized by inflammation and deposition of fibrotic tissue in the vicinity of the abdominal aorta and iliac arteries. We present a report of five patients admitted to our department between January 2014 and February 2017, diagnosed with RPF. Abdominal pain was the most common presenting symptom; however, in one patient, RPF was identified accidentally in routinely performed ultrasonography. In 4 cases, corticosteroids (CS) in combination with azathioprine were applied as first-line therapy, whereas one patient was treated with intravenous methylprednisolone pulses followed by oral CS...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769137/is-primary-sj%C3%A3-gren-s-syndrome-a-risk-factor-for-malignancies-different-from-lymphomas-what-does-the-literature-highlight-about-it
#14
REVIEW
Ciro Manzo, Melek Kechida
BACKGROUND: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease with an elevated risk of developing lymphoproliferative malignancies (LM). Whether pSS is a risk factor or not for non-lymphoma malignancies (NLM) has been scarcely evaluated in the literature. Age is per se a risk factor for malignancies: patients over 70 years old have 4 times higher risk for cancers than adults. Even if the mean age of pSS onset usually is in the 4th and 5th decade, its onset in patients aged over 65 years (Elderly Onset pSS - EOpSS) is not uncommon...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769136/nail-involvement-in-psoriatic-arthritis
#15
REVIEW
Piotr Sobolewski, Irena Walecka, Klaudia Dopytalska
Nail psoriasis is considered a significant psychological and social problem causing functional impairment in affected patients. Nail changes hamper their daily and occupational activities and contribute to a worse quality of life. Almost 50% of patients with psoriasis vulgaris and up to 80% of patients with psoriatic arthritis are afflicted with nail lesions. The important correlation between psoriatic arthritis and nail changes is well established - the presence of the latter is a strong predictor of the development of arthritis...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769135/fatigue-an-underestimated-symptom-in-psoriatic-arthritis
#16
REVIEW
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
The nature of fatigue is very complex and involves physiological, psychological and social phenomena at the same time, and the mechanisms leading to occurrence and severity of fatigue are still poorly understood. The condition of chronic inflammation associated with psoriatic arthritis can be regarded as a potential factor affecting development of fatigue. Only a few studies so far have focused on the occurrence of fatigue in psoriatic arthritis. The problem of chronic fatigue is underestimated in everyday clinical practice...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769134/rheumatology-training-in-poland-vs-united-kingdom
#17
REVIEW
Karina Lazarewicz, Hector Chinoy
When evaluating the quality of Rheumatology specialty training, it can be useful to explore similarities and differences between countries. In this article we compare the training in the UK and Poland. The two training programmes are similar in length and in the competencies that must be achieved, although they do have significant differences in the way the training is structured. The UK-based system is more out-patient based, which can be advantageous, as after completion of training the doctor is more confident in treating common rheumatological problems...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769133/the-prevalence-of-ana-antibodies-anticentromere-antibodies-and-anti-cyclic-citrullinated-peptide-antibodies-in-patients-with-primary-sj%C3%A3-gren-s-syndrome-compared-to-patients-with-dryness-symptoms-without-primary-sj%C3%A3-gren-s-syndrome-confirmation
#18
Maria Maślińska, Małgorzata Mańczak, Bożena Wojciechowska, Brygida Kwiatkowska
OBJECTIVES: Our study analyses the prevalence of ANA, anti-SS-A, anti-SS-B, and ACA and ACPA antibodies in patients with pSS and with dryness symptoms without pSS confirmation, and the association of ACPA and ACA antibodies with specific clinical symptoms. MATERIALS AND METHODS: 113 patients were divided into two groups: I - with diagnosed pSS (N = 75); and II - with dryness without pSS evidence (N = 38). Diagnostics: indirect immunofluorescence (IF; Hep-2 cell line) of antinuclear antibodies (ANA), anti-SS-A anti-SS-B antibodies determined with semi-quantitative method, autoantibody profile (14 antigens, ANA Profil 3 EUROLINE); basic laboratory, ophthalmic examination tests, minor salivary gland biopsy with focus score (FS), joint and lung evaluation, and ESSDAI questionnaire (pSS activity)...
2017: Reumatologia
https://www.readbyqxmd.com/read/28769132/rheumatic-and-oncological-diseases-common-challenges
#19
EDITORIAL
Krzysztof Jeziorski
No abstract text is available yet for this article.
2017: Reumatologia
https://www.readbyqxmd.com/read/28539685/the-11-th-central-european-congress-of-rheumatology-prague-december-8-10-2016
#20
Eugeniusz J Kucharz
No abstract text is available yet for this article.
2017: Reumatologia
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