Dian Ratih Laksmitawati, Wahyu Widowati, Rachmawati Noverina, Wireni Ayuningtyas, Dedy Kurniawan, Hanna Sari Widya Kusuma, Ervi Afifah, Ratih Rinendyaputri, Rilianawati Rilianawati, Ahmad Faried, Ni Ketut Susilarini
BACKGROUND Inflammation is the body's first response to an illness that causes irritation or infection. Inflammation is tightly correlated with aging, which is a progressive degenerative process. Conditioned medium (CM) from adipose tissue-derived mesenchymal stem cells (CM-ATMSCs) has been shown to stimulate collagen synthesis and dermal fibroblast migration, as well as reduce wrinkles and improve wound healing. This study aimed to observe the production of inflammatory modulators - interleukin (IL)-1alpha, IL-6, IL-10, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) - in CM-ATMSCs treated with fresh frozen plasma (FFP) at passages 3 (P3), 7, 11, and 15...
March 23, 2022: Medical Science Monitor Basic Research