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Medical Science Monitor Basic Research

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https://www.readbyqxmd.com/read/29142191/immune-neuroendocrine-interactions-evolution-ecology-and-susceptibility-to-illness
#1
Johanna M C Blom, Enzo Ottaviani
The integration between immune and neuroendocrine systems is crucial for maintaining homeostasis from invertebrates to humans. In the first, the phagocytic cell, i.e., the immunocyte, is the main actor, while in the latter, the principle player is the lymphocyte. Immunocytes are characterized by the presence of pro-opiomelanocortin (POMC) peptides, CRH, and other molecules that display a significant similarity to their mammalian counterparts regarding their functions, as both are mainly involved in fundamental functions such as immune (chemotaxis, phagocytosis, cytotoxicity, etc...
November 16, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29104283/identification-of-2-novel-mutations-in-atp2c1-gene-in-hailey-hailey-disease-and-a-literature-review-of-variations-in-a-chinese-han-population
#2
Kejia Xu, Bingjun Shi, Qingchun Diao, Xue Jiang, Yujuan Xiao
BACKGROUND Hailey-Hailey disease (HHD) is a rare autosomal dominant skin condition. The ATP2C1 gene was identified as the defective gene in HHD. To date, 166 pathogenic mutations in ATP2C1 have been observed worldwide. The aim of this study was to identify variations in HHD and summarize the features of the mutations identified in China. MATERIAL AND METHODS We examined 2 familial and 2 sporadic cases of HHD. Genomic DNA polymerase chain reaction and direct sequencing of the ATP2C1 were performed from HHD patients, unaffected family members, and 200 healthy individuals...
November 6, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29081492/tissue-engineered-small-vessel-conduits-the-anti-thrombotic-effect-of-re-endothelialization-of-decellularized-baboon-arteries-a-preliminary-experimental-study
#3
Muriel Meiring, Mmakgabu Khemisi, Leana Laker, Pascal M Dohmen, Francis E Smit
BACKGROUND The use of decellularized biological scaffolds for the reconstruction of small-diameter vascular grafts remains a challenge in tissue engineering. Thrombogenicity is an important cause of obstruction in these vessels due to decellularization. Seeding of the decellularized vascular constructs with endothelial cells is therefore a prerequisite for the prevention of thrombosis. The aim of this study was to seed decellularized baboon arteries with endothelial cells and to compare the thrombogenicity to that of decellularized arteries after circulation of blood...
October 30, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29033450/a-retrospective-chart-analysis-with-follow-up-of-cogmed-working-memory-training-in-children-and-adolescents-with-autism-spectrum-disorder
#4
Sander M Weckstein, Ethan J Weckstein, Christopher D Parker, Matthew W Westerman
BACKGROUND This case study was undertaken in an effort to assess whether children/adolescents with Autism Spectrum Disorder (ASD) experience improvement in comorbid ADHD following Cogmed Working Memory Training (CWMT). This treatment intervention has been shown to improve ADHD symptoms in children and adolescents; however, there have been no studies on its use with individuals with ASD. MATERIAL AND METHODS CWMT is a computer-based program that consists of 13 auditory, visual, visual spatial, and combined exercises that are practiced for 45 minutes a day, 5 days a week, for 5 weeks...
October 16, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28966340/a-new-clinically-relevant-t-score-standard-to-interpret-bone-status-in-a-sheep-model
#5
Christian Heiss, Stefanie Kern, Deeksha Malhan, Wolfgang Böcker, Markus Engelhardt, Diaa Eldin S Daghma, Sabine Stoetzel, Jakob Schmitt, Matthias Ivo, Vivien Kauschke, Katrin S Lips, Kamen Tushtev, Kurosch Rezwan, Thaqif El Khassawna
BACKGROUND Osteoporosis is diagnosed by bone loss using a radiological parameter called T-score. Preclinical studies use DXA to evaluate bone status were the T-score is referenced on bone mineral density (BMD) values of the same animals before treatment. Clinically, the reference BMD represents values of an independent group of healthy patients around 30 years old. The present study established a clinically similar T-score standard to diagnose osteoporosis in a sheep model. MATERIAL AND METHODS We used 31 female merino land sheep (average 5...
October 2, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28947729/chemical-composition-and-antioxidant-anti-inflammatory-and-antiproliferative-activities-of-lebanese-ephedra-campylopoda-plant
#6
Hany Kallassy, Mohammad Fayyad-Kazan, Rawan Makki, Yolla El-Makhour, Hasan Rammal, David Y Leger, Vincent Sol, Hussein Fayyad-Kazan, Bertrand Liagre, Bassam Badran
No abstract text is available yet for this article.
September 26, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28912415/targeting-overexpressed-activating-transcription-factor-1-atf1-inhibits-proliferation-and-migration-and-enhances-sensitivity-to-paclitaxel-in-esophageal-cancer-cells
#7
Qianyun Hao, Xuesong Zhao, Yi Zhang, Ziming Dong, Tao Hu, Ping Chen
No abstract text is available yet for this article.
September 15, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28855496/a-retrospective-study-the-significance-of-combined-testing-of-serum-markers-for-diagnosis-of-rheumatoid-arthritis
#8
Fangxiang Mu, Hong Wu, Yong Wang
BACKGROUND There have been few studies on the value of various antibody combinations in rheumatoid arthritis (RA) diagnosis, and a lack of studies with large sample sizes, especially in the Chinese population. This study retrospectively evaluated the diagnostic value of a combined assay of five auto-antibodies [anti-cyclic citrullinated peptide (anti-CCP), anti-keratin (AKA), anti-RA 33, glucose-6-phosphate isomerase (GPI), and rheumatoid factor (RF)] for RA. MATERIAL AND METHODS Data were obtained from 5,725 patients with rheumatic diseases in Southwest Hospital of Chongqing from 2011 to 2014...
August 31, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28814711/reprogramming-bone-marrow-stem-cells-to-functional-endothelial-cells-in-a-mini-pig-animal-model
#9
Franziska Schlegel, Marco Appler, Michelle Halling, Francis Edwin Smit, Friedrich-Wilhelm Mohr, Stefan Dhein, Pascal Maria Dohmen
BACKGROUND The aims of this study were to compare the morphological, biochemical, and functional properties of reprogrammed bone marrow stem cell (BMSC)-derived arterial endothelial cells (AECs) and venous endothelial cells (VECs), following adenosine triphosphate (ATP)-stimulation in a mini pig animal model. MATERIAL AND METHODS Bone marrow aspiration was performed in six adult mini pigs. Harvested mononuclear cells were isolated, cultured, and treated with vascular endothelial growth factor (VEGF) (16 µg/ml)...
August 17, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28769026/chemical-composition-antioxidant-anti-inflammatory-and-antiproliferative-activities-of-the-plant-lebanese-crataegus-azarolus-l
#10
Hany Kallassy, Mohammad Fayyad-Kazan, Rawan Makki, Yolla El-Makhour, Eva Hamade, Hasan Rammal, David Y Leger, Vincent Sol, Hussein Fayyad-Kazan, Bertrand Liagre, Bassam Badran
BACKGROUND In the present study, phytochemical screening, antioxidant, anti-inflammatory, and antiproliferative capacities of 3 extracts from leaves of Lebanese Crataegus azarolus L. were evaluated. MATERIAL AND METHODS Fresh leaves were dissolved in 3 different solvents: distilled water, ethanol, and methanol. The chemical composition was determined using high-performance liquid chromatography (HPLC) and the content of essential oil of this plant was examined by gas chromatography (GC) coupled with mass spectrometry (MS)...
August 3, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28747619/comparison-of-commercially-available-blood-collection-tubes-containing-sodium-citrate-and-hirudin-in-platelet-aggregation-testing
#11
Walter J Janse van Rensburg, Patricia van der Merwe
BACKGROUND Platelet reactivity assessment is an important tool in both the causal determination of bleeding diathesis as well as in the evaluation of the efficacy of anti-platelet therapy in patients at risk of thrombosis. Sodium citrate is the most widely used anticoagulant for hemostasis investigations. However, some doubt exists over the suitability of sodium citrate in platelet function testing. Hirudin has been suggested as a superior replacement. Nevertheless, only 1 study compared citrated and hirudin treated samples with light transmission aggregometry...
July 27, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28706178/surgery-for-cardiac-papillary-fibroelastoma-a-12-year-single-institution-experience
#12
Sabreen Mkalaluh, Marcin Szczechowicz, Saeed Torabi, Bashar Dib, Anton Sabashnikov, Ahmed Mashhour, Matthias Karck, Alexander Weymann
BACKGROUND We reviewed our clinical experience with cardiac papillary fibroelastoma from 2005 to 2017. The objective of this study was to investigate the clinical and operative data, as well as the early survival rate and immediate postoperative complications. MATERIAL AND METHODS We performed a retrospective analysis of 11 patients (eight males and three females) who underwent resection of cardiac papillary fibroelastoma in our institution. RESULTS Mean age at tumor diagnosis was 60±14 years. The mean dimension of the tumor was 14±11 mm...
July 14, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28652563/vascular-graft-impregnation-with-antibiotics-the-influence-of-high-concentrations-of-rifampin-vancomycin-daptomycin-and-bacteriophage-endolysin-hy-133-on-viability-of-vascular-cells
#13
Monika Herten, Evgeny A Idelevich, Sonja Sielker, Karsten Becker, Anna S Scherzinger, Nani Osada, Giovanni B Torsello, Theodosios Bisdas
BACKGROUND Rifampin-soaked synthetic prosthetic grafts have been widely used for prevention or treatment of vascular graft infections (VGIs). This in vitro study investigated the effect of the antibiotics daptomycin and vancomycin and the new recombinant bacteriophage endolysin HY-133 on vascular cells, as potential alternatives compared to rifampin. MATERIAL AND METHODS Primary human ECs, vascular smooth muscle cells (vSMC), and fibroblasts were cultivated in 96-well plates and incubated with rifampin, daptomycin, vancomycin, and endolysin HY-133 for 24 h...
June 27, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28615615/stat6-upregulation-promotes-m2-macrophage-polarization-to-suppress-atherosclerosis
#14
Min Gong, Xiaozhen Zhuo, Aiqun Ma
BACKGROUND Macrophages are highly heterogeneous and plastic cells that are involved in all stages of atherogenesis. They can undergo polarization by shifting between M1 and M2 functional phenotypes. However, the role of macrophage polarization and the molecular mechanism in modulating atherosclerotic plaque stability remain incompletely understood. Our study investigated the role of STAT6 in regulating macrophage phenotypes to affect atherosclerotic plaque stability. MATERIAL AND METHODS A murine atherosclerosis model with vulnerable plaques was induced with high-cholesterol diet and PCCP surgeries in ApoE-/- mice...
June 15, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28579604/association-of-dopamine-d1-and-d3-receptor-gene-polymorphisms-with-essential-hypertension-in-3-ethnic-groups-in-china
#15
Hongju Yang, Lianmei Zhong, Song Bai, YiLong Dong, Yanmei Wang, Qian Li, Qiuping Yang, Dejun Jiang, Hongyan Bi, Chunjie Xiao, Bingron Zheng
Background Material and Methods Results Conclusions.
June 5, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28522796/effects-of-%C3%AE-adrenoceptor-and-catechol-o-methyl-transferase-comt-polymorphism-on-postoperative-outcome-in-cardiac-surgery-patients
#16
Stefan Dhein, Pascal M Dohmen, Matthias Sauer, Julia Tews, Johannes Weickmann, Anne-Kathrin Funkat, Martin Misfeld, Michael A Borger, Friedrich W Mohr
BACKGROUND There is a long-standing debate about the role of beta-adrenoceptor polymorphisms in the cardiovascular system. We wanted to elucidate whether β1-adrenoceptor-polymorphisms affects the postoperative catecholamine consumption and the length of intermediate care unit stay in patients undergoing cardiac surgery, and whether this might be enhanced or attenuated by catechol-O-methyl-transferase (COMT) polymorphism. MATERIAL AND METHODS We included 116 patients (63±1.2 years; 34% females; 81±1 kg) undergoing cardiac surgery...
May 19, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28496093/prediction-of-new-onset-and-recurrent-atrial-fibrillation-by-complete-blood-count-tests-a-comprehensive-systematic-review-with-meta-analysis
#17
Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Anton Sabashnikov, Aron-Frederik Popov, Seyed Jalil Mirhosseini, Tong Liu, Mohammadreza Lotfaliani, Michel Pompeu Barros de Oliveira Sá, William L L Baker, Senol Yavuz, Mohamed Zeriouh, Jae-Sik Jang, Hamidreza Dehghan, Lei Meng, Luca Testa, Fabrizio D'Ascenzo, Umberto Benedetto, Gary Tse, Luis Nombela-Franco, Pascal M Dohmen, Abhishek J Deshmukh, Cecilia Linde, Giuseppe Biondi-Zoccai, Gregg W Stone, Hugh Calkins, Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group
BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF...
May 12, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28473687/poor-physical-performance-is-associated-with-obesity-among-university-students-in-china
#18
Tianhua Du, Ergang Zhu, Suhua Jiao
BACKGROUND The aim of this study was to explore the relationship between physical performance and BMI (body mass index) of university students in China. MATERIAL AND METHODS We conducted a cross-sectional study evaluating the physical performance and BMI of university students. BMI was calculated based on height and weight. Overweight and obesity were defined by the Working Group on Obesity references in China. RESULTS A total of 2313 participants (978 males and 1335 females) were recruited in our study. The mean value of the 50-meter dash and standing long jump in male students was higher than in female students (P<0...
May 5, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28450696/alginate-particles-with-ovalbumin-ova-peptide-can-serve-as-a-carrier-and-adjuvant-for-immune-therapy-in-b16-ova-cancer-model
#19
Longbao Zhu, Fei Ge, Liangjun Yang, Wanzhen Li, Shenghua Wei, Yugui Tao, Guocheng Du
BACKGROUND Alginate is a natural polysaccharide obtained from brown algae and has been shown to have numerous applications in biomedical science, such as wound healing, delivery of bioactive agents, and cell transplantation. Ovalbumin (OVA) peptide 323-339 has been reported to be involved in immune response.  MATERIAL AND METHODS This work investigated the use of alginate particles as a carrier and adjuvant for the immune therapy of cancer. Alginate particles loaded with OVA peptide were produced via emulsion...
April 28, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28428533/protective-effect-of-tempol-against-hypoxia-induced-oxidative-stress-and-apoptosis-in-h9c2-cells
#20
Linlin Jing, Qian Li, Lei He, Wei Sun, Zhengping Jia, Huiping Ma
Background Material and Methods Results Conclusions.
April 21, 2017: Medical Science Monitor Basic Research
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