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Cancer Medicine

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https://www.readbyqxmd.com/read/28229562/out-of-pocket-costs-and-burden-among-rural-breast-cancer-survivors
#1
Maria Pisu, Andres Azuero, Rachel Benz, Patrick McNees, Karen Meneses
Little is known about out-of-pocket (OOP) costs incurred for medical and health needs by rural breast cancer survivors and what factors may be associated with higher OOP costs and the associated economic burden. Data were examined for 432 survivors participating in the Rural Breast Cancer Survivor Intervention trial. OOP costs were collected using the Work and Finances Inventory survey at baseline and four assessments every 3 months. Mean and median OOP costs and burden (percent of monthly income spent on OOP costs) were reported and factors associated with OOP costs and burden identified with generalized linear models fitted with over-dispersed gamma distributions and logarithmic links (OOP costs) and with beta distributions with logit link (OOP burden)...
February 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28220692/diagnostic-approach-using-ercp-guided-transpapillary-forceps-biopsy-or-eus-guided-fine-needle-aspiration-biopsy-according-to-the-nature-of-stricture-segment-for-patients-with-suspected-malignant-biliary-stricture
#2
Yun Nah Lee, Jong Ho Moon, Hyun Jong Choi, Hee Kyung Kim, Seo-Youn Choi, Moon Han Choi, Tae Hee Lee, Tae Hoon Lee, Sang-Woo Cha, Sang-Heum Park
In malignant biliary stricture (MBS), the diagnostic accuracy of ERCP-based tissue sampling is insufficient. EUS-guided fine needle aspiration biopsy (EUS-FNAB) is emerging as a reliable diagnostic procedure. This study aimed to evaluate the usefulness of a diagnostic approach using ERCP-guided transpapillary forceps biopsy (TPB) or EUS-FNAB according to the characteristics of suspected MBS. Consecutive patients diagnosed with suspected MBS with obstructive jaundice and/or cholangitis were enrolled prospectively...
February 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28220687/environmental-factors-seven-gwas-identified-susceptibility-loci-and-risk-of-gastric-cancer-and-its-precursors-in-a-chinese-population
#3
Meng Cai, Shuyang Dai, Wanqing Chen, Changfa Xia, Lingeng Lu, Shuguang Dai, Jun Qi, Minjie Wang, Meilin Wang, Lanping Zhou, Fuhua Lei, Tingting Zuo, Hongmei Zeng, Xiaohang Zhao
Gene-environment interactions may increase gastric cancer (GC) risk. Seven susceptibility loci identified by genome-wide association studies (GWASs) suggest that genetic factors play a role in gastric carcinogenesis. Meanwhile, Helicobacter pylori (H. pylori) infection, smoking, and alcohol drinking are also important environmental factors for gastric cancer. However, studies to explore the role of gene-environment interactions in gastric carcinogenesis, and particularly the relationship between the seven susceptibility loci and their potential interactions with H...
February 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28220683/analysis-of-distinct-long-noncoding-rna-transcriptional-fingerprints-in-pancreatic-ductal-adenocarcinoma
#4
Xiang Yu, Yang Lin, Wu Sui, Yanfen Zou, Zhongchuan Lv
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies with the worst prognosis. Recent studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in tumorigenesis and cancer progression. However, the expression pattern and roles of lncRNAs in the development of PDAC remain unknown. Herein, we globally analyzed the lncRNA expression profile in human PDAC and non-tumor tissues using four independent public microarray datasets from Gene Expression Omnibus (GEO)...
February 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28220627/downregulation-of-mirna-141-in-breast-cancer-cells-is-associated-with-cell-migration-and-invasion-involvement-of-anp32e-targeting
#5
Ping Li, Tao Xu, Xin Zhou, Liangying Liao, Guolian Pang, Wan Luo, Lu Han, Jiankun Zhang, Xianyong Luo, Xiaobing Xie, Kuichun Zhu
MicroRNAs (miRNAs) regulate many cellular activities, including cancer development, progression, and metastasis. Some miRNAs are involved in breast cancer (BC) migration and invasion, thus affect patients' prognosis. Microarray analysis was performed to compare miRNA expression in BC tissues, and results confirmed by qPCR. BC cell migration and invasion were studied in vitro with MDA-MB-231 cells using microplate transwell assays. miRNA targeting was investigated using luciferase assays, qPCR, and Western blot analysis in cells with overexpression of miRNA mimics...
February 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211638/the-relationship-between-ovarian-function-and-ovarian-limited-dose-in-radiotherapy-postoperation-of-ovarian-transposition-in-young-patients-with-cervical-cancer
#6
Zhenhua Du, Hui Qu
In this study, the relationship between ovarian function and ovarian limited dose in radiotherapy was evaluated in young patients with cervical cancer who underwent ovarian transposition (Fig1B). Moreover, the novel ovarian dose limit for a better preservation of ovarian function in intensity-modulated radiation therapy (IMRT) was determined. We retrospectively analyzed data from 86 patients with cervical cancer who received radical hysterectomy and ovarian transposition from January 2013 to June 2015. In agreement with the National Comprehensive Cancer Network Guidelines (NCCN) for Cervical Cancer Version 2...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211618/a-comparison-between-lynch-syndrome-and-sporadic-colorectal-cancer-survivors-satisfaction-with-their-healthcare-providers
#7
Allison M Burton-Chase, Wendy M Parker, Katrina M Polivka, Ellen R Gritz, Christopher I Amos, Karen H Lu, Patrick M Lynch, Miguel A Rodriguez-Bigas, Y Nancy You, Susan K Peterson
This study evaluated provider satisfaction in a sample of colorectal cancer (CRC) survivors with and without Lynch syndrome (LS). Participants were case-case-matched CRC survivors with (n = 75) or without (n = 75) LS (mean age of 55; range: 27-93). Participants completed a mailed questionnaire assessing demographics, clinical characteristics, healthcare utilization, psychosocial variables, and provider satisfaction. LS CRC survivors reported lower provider satisfaction scores on three subscales of the Primary Care Assessment Survey: communication (78...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211617/phosphorylation-of-prb-mechanism-for-rb-pathway-inactivation-in-mycn-amplified-retinoblastoma
#8
Kathryn G Ewens, Tricia R Bhatti, Kimberly A Moran, Jennifer Richards-Yutz, Carol L Shields, Ralph C Eagle, Arupa Ganguly
A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification. This manuscript investigated alternate pathways of inactivating pRb, the encoded protein in these tumors. We analyzed the mutation status of the RB1 gene and MYCN copy number in a series of 245 unilateral retinoblastomas, and the phosphorylation status of pRb in a subset of five tumors using immunohistochemistry. There were 203 tumors with two mutations in RB1 (RB1(-/-) , 83%), 29 with one (RB1(+/-) , 12%) and 13 with no detectable mutations (RB1(+/+) , 5%)...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211615/targeting-of-crosstalk-between-tumor-and-tumor-microenvironment-by-%C3%AE-d-mannuronic-acid-m2000-in-murine-breast-cancer-model
#9
Fatemeh Hosseini, Hadi Hassannia, Ahmad Mahdian-Shakib, Farhad Jadidi-Niaragh, Seyedehsan Enderami, Mohammadjavad Fattahi, Ali Anissian, Abbas Mirshafiey, Parviz Kokhaei
Metastasis is the main cause of death in breast cancer patients. Inflammatory processes following crosstalk between tumor cells and tumor microenvironment play an important role in progression and metastasis of cancer. Hence, targeting of these interactions may represent a novel promising strategy for breast cancer therapy. So, we investigated the effects of β-D mannuronic acid (BDM), a new antiinflammatory agent, on 4T1 breast cancer cell line both in vitro and in vivo. Proliferation assays revealed low-cytotoxic effect of BDM on 4T1 cells...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211614/opportunities-for-improving-triple-negative-breast-cancer-outcomes-results-of-a-population-based-study
#10
Elisabetta Rapiti, Kim Pinaud, Pierre O Chappuis, Valeria Viassolo, Aurélie Ayme, Isabelle Neyroud-Caspar, Massimo Usel, Christine Bouchardy
Triple-negative breast cancer (TNBC) is associated with a poor prognosis. Surgery, radiotherapy, chemotherapy, and referral for genetic counseling are the standard of care. We assessed TNBC prevalence, management, and outcome using data from the population-based Geneva cancer registry. 2591 women had a first invasive stage I-III breast cancer diagnosed between 2003 and 2011. We compared TNBC to other breast cancers (OBC) by χ(2) -test and logistic regression. Kaplan-Meier survival curves, up to 31-12-2014, were compared using log-rank test...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211613/novel-anticarcinoembryonic-antigen-antibody-drug-conjugate-has-antitumor-activity-in-the-existence-of-soluble-antigen
#11
Daisuke Shinmi, Ryosuke Nakano, Keisuke Mitamura, Minami Suzuki-Imaizumi, Junko Iwano, Yuya Isoda, Junichi Enokizono, Yasuhisa Shiraishi, Emi Arakawa, Kazuma Tomizuka, Kazuhiro Masuda
Carcinoembryonic antigen (CEA) is a classic tumor-specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti-CEA antibodies have been tested, to the best of our knowledge, there are currently no clinically approved anti-CEA antibody therapies. Because of this, we have created the novel anti-CEA antibody, 15-1-32, which exhibits stronger binding to membrane-bound CEA on cancer cells than existing anti-CEA antibodies. 15-1-32 also shows poor affinity for soluble CEA; thus, the binding activity of 15-1-32 to membrane-bound CEA is not influenced by soluble CEA...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211612/genetic-variants-in-the-plasminogen-activator-inhibitor-1-gene-are-associated-with-an-increased-risk-of-radiation-pneumonitis-in-lung-cancer-patients
#12
Bo Liu, Yang Tang, Minxiao Yi, Qingxu Liu, Huihua Xiong, Guangyuan Hu, Xianglin Yuan
Plasminogen activator inhibitor-1 (PAI-1) plays a crucial role in the process of lung injury, although its association with radiation pneumonitis (RP) is unclear. We hypothesized that genetic variants in PAI-1 may influence the risk of RP. In this study, 169 lung cancer patients were genotyped for six single-nucleotide polymorphisms in PAI-1 using the Sequenom MassARRAY system. The risk of RP was evaluated by Cox proportional hazards analyses. The cumulative RP probabilities by genotype were assessed using Kaplan-Meier analyses...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28205361/immunotherapy-against-metastatic-bladder-cancer-by-combined-administration-of-granulocyte-macrophage-colony-stimulating-factor-and-interleukin-2-surface-modified-mb49-bladder-cancer-stem-cells-vaccine
#13
Chun-Yan Wang, Rui Hua, Li Liu, Xiaomin Zhan, Simei Chen, Song Quan, Qing-Jun Chu, Yong-Tong Zhu
In previous studies, it has been shown that the granulocyte macrophage-colony stimulating factor (GM-CSF) or interleukin-2 (IL-2) surface modified MB49 bladder cancer stem cells (MCSCs) vaccine could induce a specific antitumor immunity and against bladder cancer in mice model respectively. However, whether combined administration of GM-CSF and IL-2 could produce specific immune responses to cancer stem cells (CSCs) was uncertain. MCSCs were established and characterized. GM-CSF and IL-2 MCSCs vaccines were prepared and bioactivity was evaluated...
February 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28188703/the-effect-of-radiation-therapy-in-the-treatment-of-adult-soft-tissue-sarcomas-of-the-extremities-a-long-term-community-based-cancer-center-experience
#14
Jeffrey S Kneisl, Chad Ferguson, Myra Robinson, Anthony Crimaldi, Will Ahrens, James Symanowski, Michael Bates, Jennifer L Ersek, Michael Livingston, Joshua Patt, Edward S Kim
The aim of the study was to determine the effect of external beam radiotherapy (RT) in the treatment of extremity soft tissue sarcoma (STS) before or after limb-sparing surgery (LSS) in a community-based setting. Patients presenting to our institution from 1992 to 2010 and meeting eligibility criteria were stratified into low (G1) or high (G2, G3) pathologic grade and evaluated. Major complication events, including amputation, radiation-induced sarcoma, and pathologic fracture, were assessed. Kaplan-Meier techniques and Cox proportional hazards regression models were used...
February 11, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28181425/induction-of-cell-death-by-pyropheophorbide-%C3%AE-methyl-ester-mediated-photodynamic-therapy-in-lung-cancer-a549-cells
#15
Ping-Hua Tu, Wen-Jun Huang, Zhan-Ling Wu, Qing-Zhen Peng, Zhi-Bin Xie, Ji Bao, Ming-Hua Zhong
Pyropheophorbide-α methyl ester (MPPa) was a promising photosensitizer with stable chemical structure, strong absorption, higher tissue selectivity and longer activation wavelengths. The present study investigated the effect of MPPa-mediated photodynamic treatment on lung cancer A549 cells as well as the underlying mechanisms. Cell Counting Kit-8 was employed for cell viability assessment. Reactive oxygen species levels were determined by fluorescence microscopy and flow cytometry. Cell morphology was evaluated by Hoechst staining and transmission electron microscopy...
February 9, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28181423/next-generation-sequencing-of-mirnas-in-clinical-samples-of-epstein-barr-virus-associated-b-cell-lymphomas
#16
Kouta Sakamoto, Tsuyoshi Sekizuka, Taeko Uehara, Tsunekazu Hishima, Sohtaro Mine, Hitomi Fukumoto, Yuko Sato, Hideki Hasegawa, Makoto Kuroda, Harutaka Katano
Epstein-Barr virus (EBV) encodes 49 microRNAs (miRNAs) in the BART and BHRF1 regions of its genome. Although expression profiles of EBV-encoded miRNAs have been reported for EBV-positive cell lines and nasopharyngeal carcinoma, to date there is little information about total miRNA expression, including cellular and viral miRNAs, in the primary tumors of EBV-associated B-lymphoproliferative disorders. In this study, next-generation sequencing and quantitative real-time reverse transcription-PCR were used to determine the expression profiles of miRNAs in EBV-infected cell lines and EBV-associated B-cell lymphomas, including AIDS-related diffuse large B-cell lymphoma (DLBCL), pyothorax-associated lymphoma, methotrexate-associated lymphoproliferative disorder, EBV-positive DLBCL of the elderly, and Hodgkin lymphoma...
February 9, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28155253/characterization-of-key-transcription-factors-as-molecular-signatures-of-hpv-positive-and-hpv-negative-oral-cancers
#17
Gaurav Verma, Kanchan Vishnoi, Abhishek Tyagi, Mohit Jadli, Tejveer Singh, Ankit Goel, Ankita Sharma, Kiran Agarwal, Subhash Chandra Prasad, Durgatosh Pandey, Shashi Sharma, Ravi Mehrotra, Sukh Mahendra Singh, Alok Chandra Bharti
Prior studies established constitutively active AP-1, NF-κB, and STAT3 signaling in oral cancer. Differential expression/activation of specific members of these transcription factors has been documented in HPV-positive oral lesions that respond better to therapy. We performed a comprehensive analysis of differentially expressed, transcriptionally active members of these pivotal signaling mediators to develop specific signatures of HPV-positive and HPV-negative oral lesions by immunohistochemical method that is applicable in low-resource settings...
February 3, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28145091/low-utility-of-oncotype-dx%C3%A2-in-the-clinic
#18
Luisel J Ricks-Santi, John Tyson McDonald
Precision medicine tools are currently making their way into the clinic and being utilized to diagnose, prognose, and individualize cancer care. The multi-gene expression-based assay, Oncotype DX® (ODX), is a genomic tumor profiling tool that determines the expression of 21 tumor- associated genes; it helps determine the risk for distant recurrence and whether chemotherapy is an appropriate course of treatment in patients with early stage, estrogen receptor (ER) positive, HER2 negative, and lymph node negative (or 1-3 positive lymph nodes) invasive BCa...
February 1, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28135055/mir-101-and-doxorubicin-codelivered-by-liposomes-suppressing-malignant-properties-of-hepatocellular-carcinoma
#19
Fei Xu, Jia-Zhi Liao, Guang-Ya Xiang, Peng-Xuan Zhao, Feng Ye, Qiu Zhao, Xing-Xing He
MiR-101, an important tumor-suppressive microRNA (miRNA) in hepatocellular carcinoma (HCC), has been affirmed significantly downregulated in HCC and participated in promoting apoptosis, decreasing proliferation and invasiveness of HCC cells, as well as increasing sensitivity of chemotherapeutic drug. However, miR-101-based combination therapies with doxorubicin (DOX) are not reported yet. Recently, nanomaterials-based approaches, especially liposome formulations, have been approved for clinical use and seem to provide a great opportunity to codeliver therapeutic agents for cancer therapy...
January 30, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28135050/automated-home-monitoring-and-management-of-patient-reported-symptoms-during-chemotherapy-results-of-the-symptom-care-at-home-rct
#20
Kathi H Mooney, Susan L Beck, Bob Wong, William Dunson, Debra Wujcik, Meagan Whisenant, Gary Donaldson
Technology-aided remote interventions for poorly controlled symptoms may improve cancer symptom outcomes. In a randomized controlled trial, the efficacy of an automated symptom management system was tested to determine if it reduced chemotherapy-related symptoms. Prospectively, 358 patients beginning chemotherapy were randomized to the Symptom Care at Home (SCH) intervention (n = 180) or enhanced usual care (UC) (n = 178). Participants called the automated monitoring system daily reporting severity of 11 symptoms...
January 30, 2017: Cancer Medicine
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