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Cancer Medicine

Xiao-Guang Zhang, Tong Zhang, Chang-Ying Li, Ming-Hao Zhang, Fang-Min Chen
CD164 was found to play a role in many malignant diseases. But the roles of CD164 in human bladder cancer have not yet been studied. The object of our study was to investigate the functions of CD164 in urothelial bladder carcinoma. The immunohistochemistry (IHC) was performed to evaluate the associations between the expression level of CD164 and clinical-pathological features of patients, and IHC was used to analyze the relationship between CD164 and CXCR4 in tumor tissues. Real-time qPCR and Western blot were used to measure the expression of relevant genes...
July 18, 2018: Cancer Medicine
Shen Zhao, Ting Zhou, Shuxiang Ma, Yuanyuan Zhao, Jianhua Zhan, Wenfeng Fang, Yunpeng Yang, Xue Hou, Zhonghan Zhang, Gang Chen, Yaxiong Zhang, Yan Huang, Li Zhang
Concurrent chemoradiotherapy (CRT) has been recommended and applied widely as the standard treatment for limited-stage small cell lung cancer (LS-SCLC). However, controversies remain regarding the optimal timing and treatment duration of thoracic radiotherapy (TRT), and their effects on patient survival. To evaluate prognostic values of TRT timing and duration on progression-free survival (PFS) in LS-SCLC and their dependence on TRT fractionation and clinicopathological characteristics, we retrospectively analyzed 197 LS-SCLC patients receiving CRT from 2000 to 2016 at Sun Yat-sen University Cancer Center...
July 17, 2018: Cancer Medicine
Carmen Binder, Katarina Luise Matthes, Dimitri Korol, Sabine Rohrmann, Holger Moch
BACKGROUND: Cancer of unknown primary (CUP) is a distinct clinicopathological entity with poor prognosis, frequently resistant to chemotherapy. Comprehensive genomic profiling (CGP) by next-generation sequencing potentially identifies novel treatment options for CUP patients. The objective of this study was to determine incidence and survival trends and to discuss the value of CGP in CUP patients. METHODS: Age-standardized incidence rates (ASR) per 100 000 were calculated for 2935 CUP patients from 1981 to 2014 using cancer registry data of the canton of Zurich, Switzerland...
July 17, 2018: Cancer Medicine
Sandjar Djalalov, Lisa Masucci, Wanrudee Isaranuwatchai, William Evans, Alice Peter, Rebecca Truscott, Erin Cameron, Nicole Mittmann, Linda Rabeneck, Kelvin Chan, Jeffrey S Hoch
Quitting smoking after a diagnosis of cancer results in greater response to treatment and decreased risk of disease recurrence and second primary cancers. The objective of this study was to evaluate the potential cost-effectiveness of two smoking cessation approaches: the current basic smoking cessation program consisting of screening for tobacco use, advice, and referral; and a best practice smoking cessation program that includes the current basic program with the addition of pharmacological therapy, counseling, and follow-up...
July 17, 2018: Cancer Medicine
Ruonan Liu, Hailong Guo, Shifen Lu
OBJECTIVE: Our study was designed to explore the association miR-335-5p and BCL2L2 and to investigate the influence of miR-335-5p/BCL2L2 axis on cisplatin-resistant ovarian cancer cells. METHODS: Microarray analysis was used to determine differentially expressed microRNAs in primary and cisplatin-resistant A2780 cells. Cell function experiments were conducted to investigate the effect of miR-335-5p on the cisplatin sensitivity of A2780 cells. The targeted relationship between BCL2L2 mRNA and miR-335-5p was validated through luciferase assay...
July 17, 2018: Cancer Medicine
Xiao-Bo Ma, Yan-Ping Zhong, Yan Zheng, Jing Jiang, Yin-Ping Wang
Both CD5 and CD43 are expressed on the surface of B lymphocytes of definite phase and associated with the adverse outcome in diffuse large B-cell lymphoma (DLBCL). However, the relationship between CD5 and CD43 expression and the prognostic value of CD5/CD43 coexpression in DLBCL are unknown. We herein determined the correlation between CD5 and CD43 expression, as separate factors or in combination, with the clinicopathological features and survival of 200 patients with DLBCL receiving standard chemotherapy with or without rituximab...
July 17, 2018: Cancer Medicine
Theresa A Hastert, Gregory S Young, Michael L Pennell, Tasleem Padamsee, S Yousuf Zafar, Cecilia DeGraffinreid, Michelle Naughton, Michael Simon, Electra D Paskett
BACKGROUND: Increasing attention is being paid to financial burdens of cancer survivorship, but little is known about the prevalence and predictors of these burdens in older, long-term survivors. METHODS: We used data from 6012 participants diagnosed with cancer since enrolling in the Women's Health Initiative, and who participated in the Life and Longevity After Cancer (LILAC) ancillary study to estimate prevalence and identify predictors of financial burden. We used logistic regression to identify sociodemographic, socioeconomic, health- and cancer-related factors associated with financial burden and backward selection to build a final multivariable model...
July 17, 2018: Cancer Medicine
Jun-Chao Xie, Shuai Yang, Xue-Yuan Liu, Yan-Xin Zhao
The relationship between marital status and glioblastoma multiforme (GBM) has not been addressed in depth. Here, we aimed to investigate the association between marital status and survival in GBM. We searched the Surveillance, Epidemiology, and End Results (SEER) database and extracted the data of eligible patients diagnosed with GBM after 2004. Marital status was classified as married, divorced/separated, widowed, and single. A Kaplan-Meier test was conducted to compare the survival curves of different groups...
July 15, 2018: Cancer Medicine
Lei Qin, Yi-Wei Kao, Yueh-Lung Lin, Bou-Yue Peng, Win-Ping Deng, Tsung-Ming Chen, Kuan-Chou Lin, Kevin Sheng-Po Yuan, Alexander T H Wu, Ben-Chang Shia, Szu-Yuan Wu
BACKGROUND: Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan. MATERIALS AND METHODS: We selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non-RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching...
July 15, 2018: Cancer Medicine
Huai-Hsuan Huang, Yao-Chun Wen, Ho-Min Chen, Fei-Yuan Hsiao, Bor-Sheng Ko
Follicular lymphoma (FL) is the most frequent indolent lymphoma in Western countries, but it is less frequent in Asia. Several trials have demonstrated the progression-free benefit of rituximab maintenance for FL patients in Western countries. However, the overall survival (OS) benefits and effectiveness of rituximab maintenance in Asian FL patients remain uncertain. We utilized the Taiwan Cancer Registry Database and the National Health Insurance Research Database to investigate the roles of rituximab maintenance for newly diagnosed FL patients in Taiwan...
July 15, 2018: Cancer Medicine
Prashant Gabani, Justin Barnes, Alexander J Lin, Soumon Rudra, Peter Oppelt, Douglas Adkins, Jason T Rich, Jose P Zevallos, Mackenzie D Daly, Hiram A Gay, Wade L Thorstad
The role of induction chemotherapy in nasopharyngeal carcinoma (NPC) remains controversial. The primary aim of this study was to use the National Cancer Database to evaluate the patterns of care of induction chemotherapy in NPC and its impact on overall survival (OS). Patients with NPC from 2004 to 2014 were obtained from the NCDB. Patients were considered to have received induction chemotherapy if it was started ≥43 days before the start of RT and concurrent CRT if chemotherapy started within 21 days after the start of RT...
July 14, 2018: Cancer Medicine
Bing Zhu, Jie Luo, Yiyao Jiang, Luhua Yu, Mulin Liu, Jun Fu
Interleukin (IL)-37 and neutrophils are considered to be involved in human cancer, but their prognostic significance in colorectal cancer (CRC) has not been elucidated. The aim of this study was to evaluate the prognostic value of IL-37 expression and neutrophil levels in CRC. We retrospectively analyzed IL-37 expression, CD66b+ neutrophil levels, and mismatch repair (MMR) status in 337 paraffin-embedded CRC specimens from the training cohort by immunohistochemistry. Their prognostic values were assessed using Kaplan-Meier curves and multivariate Cox regression models...
July 13, 2018: Cancer Medicine
Wei Peng, Ya-Nan Liu, Si-Qiang Zhu, Wen-Qiang Li, Feng-Cheng Guo
This study aimed to explore the correlation of circulating pro-angiogenic miRNAs' expressions with risk, clinicopathological features, and survival profiles in gastric cancer (GC). Three hundred and thirty-three GC patients underwent radical resection and 117 health controls (HCs) were recruited for this study. Plasma samples were obtained from GC patients before the operation and from HCs after enrollment. Fourteen pro-angiogenic miRNAs were asseassed by quantitative polymerase chain reaction (qPCR). Disease-free survival (DFS) and overall survival (OS) of GC patients were calculated and the median follow-up duration was 36...
July 12, 2018: Cancer Medicine
Cheng-Wei Lu, Dan-Dan Zhou, Tian Xie, Ji-Long Hao, Om Prakash Pant, Cheng-Bo Lu, Xiu-Fen Liu
The cancers are the leading cause of disease-related deaths worldwide with a high risk of morbidity and mortality. Long noncoding RNAs (lncRNAs) play a critical role in a wide range of biological processes, including tumorigenesis. HOXA11-AS (NCRNA00076), the antisense strands of HOXA11 gene, was initially revealed in a mouse embryonic cDNA library in 2009 and it was a fairly novel lncRNA. This review summarized the advanced research progression concerning the expression and role of HOXA11-AS in different human malignancies...
July 10, 2018: Cancer Medicine
Qi Liu, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li
AIM: This study aimed to investigate circumferential resection margin (CRM) as a prognostic factor for long-term oncologic survival after rectal cancer surgery. METHODS: Patients diagnosed with malignant rectal cancer between 1 January 2010 and 31 December 2014, from the Surveillance, Epidemiology, and End Results (SEER) program were identified for this study. The patients were divided into five CRM groups to compare the baseline characteristics and assess cancer-specific survival (CSS): 0-1 mm, 1...
July 10, 2018: Cancer Medicine
Wu Jingjing, Guo Wenzheng, Wen Donghua, Hou Guangyu, Zhou Aiping, Wu Wenjuan
BACKGROUND: The immune checkpoint protein programmed cell death ligand 1 (PD-L1) binds to PD1 to promote tumor cell escape from the killing effect of the immune system. However, there are few studies on the regulatory mechanisms of PD-L1 in tumors. Although PD-L1 has been reported to undergo ubiquitination in some cancers, its regulatory mechanisms in oral squamous cell carcinoma (OSCC) are unclear. Therefore, we aimed to investigate this phenomenon. METHODS: We examined the expression and function of USP9X and PD-L1 in human oral keratinocytes (HOK) and OSCC cell lines (HN4 and HN30) as the control and relevant cancer cells using western blotting, immunoprecipitation, immunohistochemistry (IHC), T-cell-mediated tumor cell killing assay, and liquid chromatography-mass spectrometry...
July 10, 2018: Cancer Medicine
Jinna Wu, Huanhuan Sun, Jie Li, Yuanqing Guo, Kuibo Zhang, Chuandong Lang, Changye Zou, Haiqing Ma
PURPOSE: Osteosarcoma is the most common primary malignancy of bone, and typically occurs among children and adolescence. This study aims to evaluate treatment outcomes among children, adolescents and young adults with osteosarcoma over the three decades by the changes in the long-term relative survival. METHODS: Osteosarcoma incidence and relative survival data from Surveillance, Epidemiology, and End Results (SEER) registries during 1984-2013 were analyzed. The survival differences over three decades, age, sex, race, and socioeconomic status (SES) were assessed by comparing Kaplan-Meier curves...
July 10, 2018: Cancer Medicine
Wenting Ni, Wenxing Chen, Yin Lu
Brain metastasis is an important cause of morbidity and mortality in cancer patients. Hence, the need to develop improved therapies to prevent and treat metastasis to the brain is becoming urgent. Recent studies in this area are bringing about some advanced progress on brain metastasis. It was concluded that the occurrence and poor prognosis of brain metastasis have been mostly attributed to the exclusion of anticancer drugs from the brain by the blood-brain barrier. And several highly potent new generation targeted drugs with enhanced CNS distribution have been developed constantly...
July 10, 2018: Cancer Medicine
Myong Kim, Jong Won Kim, Jong Keun Kim, Sang Mi Lee, Cheryn Song, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn
BACKGROUND: We evaluated the association between serum levels of insulin-like growth factor-1 (IGF-1), bioavailable testosterone, and surgical Gleason score (GS). METHODS: We analyzed 793 patients who underwent radical prostatectomy and 272 men with negative prostate biopsy. Serum levels of IGF-1 and testosterone were measured before surgery or biopsy. RESULTS: The mean IGF-1 levels of prostate cancer patients and men with a negative biopsy were 143...
July 10, 2018: Cancer Medicine
Yun Zhou, Ke-Ting Que, Zhen Zhang, Zu J Yi, Ping X Zhao, Yu You, Jian-Ping Gong, Zuo-Jin Liu
PURPOSE: Macrophages play critical roles in inflammation and wound healing and can be divided into two subtypes: classically activated (M1) and alternatively activated (M2) macrophages. Macrophages also play important roles in regulating iron homeostasis, and intracellular iron accumulation induces M1-type macrophage polarization which provides a potential approach to tumor immunotherapy through M2 tumor-associated macrophage repolarization. However, the mechanisms underlying iron-induced M1 polarization remain unclear...
July 10, 2018: Cancer Medicine
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