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Cancer Medicine

Marinos Tsiatas, Konstantine T Kalogeras, Kyriaki Manousou, Ralph M Wirtz, Helen Gogas, Elke Veltrup, Flora Zagouri, Georgios Lazaridis, Angelos Koutras, Christos Christodoulou, George Pentheroudakis, Constantina Petraki, Dimitrios Bafaloukos, Dimitrios Pectasides, Paris Kosmidis, Epaminontas Samantas, Charisios Karanikiotis, Pavlos Papakostas, Meletios-Athanassios Dimopoulos, George Fountzilas
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic value in several cancer types. In early breast cancer, TILs have a prognostic utility, as well, especially in HER2-positive and triple-negative breast cancer. TILs presence is broadly associated with improved survival; however, there is controversy regarding TILs subpopulations. PATIENTS AND METHODS: Early-stage breast cancer patients treated with anthracycline-based chemotherapy within two randomized trials were included in the study...
September 21, 2018: Cancer Medicine
Wanting Feng, Yongfei Li, Jiahui Chu, Jun Li, Yanhong Zhang, Xiaorong Ding, Ziyi Fu, Wei Li, Xiang Huang, Yongmei Yin
Triple-negative breast cancer (TNBC), an intrinsic subtype of breast cancer, is characterized by aggressive pathology and shorter overall survival. Yet there is no effective therapy for these patients. Breast cancer stem cells (BCSCs) in TNBC may account for treatment failure. It is urgent to identify new therapeutic targets for TNBC. tRNA-derived small noncoding RNAs (tDRs) represent a new class of small noncoding RNAs (sncRNA), which have been reported in some human diseases and biological processes. However, there is no detailed information about the relationship between tDRs and BCSCs...
September 21, 2018: Cancer Medicine
Hui Xu, Yu-Li Hao, Li-Na Xu, Liang Chen, Feng-Wei Xu
Laryngeal cancer is a common cancer occurred in the head and neck. Irradiation sensitivity is a problem affecting the treatment of laryngeal cancer. Tanshinone IIA has been reported to play an important role in treating multiple diseases; yet, whether Tanshinone IIA can be an irradiation sensitizer has not been reported. Clonogenic assay, annexin-V/propidium iodide double-staining assay, and Cell Counting Kit-8 assay were performed to detect cell survival, proliferation, apoptosis, and viability. Mouse laryngeal cancer xenograft model was established and subjected to tumor size analysis...
September 21, 2018: Cancer Medicine
Masayuki Urabe, Tetsuo Ushiku, Aya Shinozaki-Ushiku, Akiko Iwasaki, Sho Yamazawa, Hiroharu Yamashita, Yasuyuki Seto, Masashi Fukayama
Adenocarcinoma of the esophagogastric junction (AEG) has heterogeneous carcinogenic process due to its location straddling the esophagogastric junction. We assessed background mucosal pathology and its correlation with clinicopathological features of each Siewert type of AEG. Clinicopathological and immunohistochemical analyses of 103 AEGs and 58 gastric cancers (GCs) were conducted. Background mucosal features were evaluated according to the updated Sydney System. Siewert classification divided 103 AEGs into three type I, 75 type II, and 25 type III tumors, respectively...
September 21, 2018: Cancer Medicine
Rui Zhang, Ping Li, Qin Li, Yunfeng Qiao, Tangpeng Xu, Peng Ruan, Qibin Song, Zhenming Fu
OBJECTIVES: The survival advantage of radiotherapy (RT) for patients with stage IV non-small cell lung cancer (NSCLC) has not been adequately evaluated. METHODS: We analyzed stage IV NSCLC patients enrolled from the Surveillance, Epidemiology, and End Results (SEER) registry through January 2010 to December 2012. Propensity score (PS) analysis with 1:1 nearest neighbor matching method was used to ensure well-balanced characteristics of all comparison groups by histological types and metastatic sites...
September 21, 2018: Cancer Medicine
Stéphanie Goujon, Evangelia Kyrimi, Laure Faure, Sandra Guissou, Denis Hémon, Brigitte Lacour, Jacqueline Clavel
BACKGROUND: Significant increases in childhood cancer incidence since the 1970s have been consistently reported worldwide, but the persistence of the increase on recent periods is discussed. No conclusion can be drawn concerning the spatial variations of childhood cancer, either. This study is an in-depth investigation of the spatial and temporal variations of childhood cancer in France. An extensive review of all the studies published since 2000 on those issues is provided. METHODS: The study included 25 877 cases of childhood cancer registered nationwide over 2000-2014...
September 19, 2018: Cancer Medicine
Junsheng Fan, Tszhei Fong, Zengfei Xia, Jian Zhang, Peng Luo
PURPOSE: The current study was carried out to compare the effectiveness and safety of different ALK inhibitors in treating ALK+ NSCLC. METHODS: Progression-free survival (PFS), disease control rate (DCR), overall response rate (ORR), and intracranial ORR and DCR have been aggregated to appraise the effectiveness of each ALKi. The discontinuation rate due to adverse events (AEs) was pooled to evaluate their safety. Bayesian network meta-analyses were used to compare the ORR, DCR, PFS, and discontinuation rate of patients treated with alectinib, ceritinib, crizotinib, and chemotherapy...
September 19, 2018: Cancer Medicine
Jaewook Ryu, Jaehyuk Pyo, Chang-Woo Lee, Ja-Eun Kim
The Aurora kinase family of serine/threonine protein kinases comprises Aurora A, B, and C and plays an important role in mitotic progression. Several inhibitors of Aurora kinase have been developed as anti-cancer therapeutics. Here, we examined the effects of a pan-Aurora kinase inhibitor, AMG900, against glioblastoma cells. AMG900 inhibited proliferation of A172, U-87MG, and U-118MG glioblastoma cells by upregulating p53 and p21 and subsequently inducing cell cycle arrest and senescence. Abnormal cell cycle progression was triggered by dysregulated mitosis...
September 17, 2018: Cancer Medicine
Dounya Schoormans, Pauline A J Vissers, Myrthe P P van Herk-Sukel, Johan Denollet, Susanne S Pedersen, Susanne O Dalton, Nina Rottmann, Lonneke van de Poll-Franse
We examined the incidence of cardiovascular disease (CVD) among 32 757 cancer survivors and age-, gender-, and geographically matched cancer-free controls during a follow-up period of 1-13 years, and explored whetherCVD incidence differed by received cancer treatment, traditional cardiovascular risk factors, age, or gender. Adult 1-year cancer survivors without a history ofCVD diagnosed with breast (n = 6762), prostate (n = 4504), non-Hodgkin (n = 1553), Hodgkin (n = 173), lung and trachea (n = 2661), basal cell carcinoma (BCC; n = 12 476), and colorectal (n = 4628) cancer during 1999-2011 were selected from the Netherlands Cancer Registry and matched to cancer-free controls without a history ofCVD...
September 15, 2018: Cancer Medicine
Pratiek N Matkar, Eric D Jong, Ramya Ariyagunarajah, Gerald J Prud'homme, Krishna K Singh, Howard Leong-Poi
Neuropilins (NRPs) have been described as receptors for class 3 semaphorins and coreceptors for a plethora of ligands, such as members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines and transforming growth factor (TGF). Initial studies using genetic models have indicated that neuropilin-1 (NRP-1) is essential for axonal guidance during neuronal and cardiovascular development, regulated via semaphorins and VEGF, respectively, whereas the other homolog of neuropilin, NRP-2, has been shown to play a more specific role in neuronal patterning and lymphangiogenesis...
September 14, 2018: Cancer Medicine
Jaromir Gumulec, Martina Raudenska, Dalibor Pacik, Mariana Plevova, Alena Sorokac-Kubolkova, Zuzana Lackova, Natalia Cernei, Vladislav Strmiska, Ondrej Zitka, Zbynek Heger, Vojtech Adam
To date, there has been no evidence regarding the association between urinary sarcosine content and prostate cancer survival. Our main objective was to investigate whether levels of post-treatment urinary sarcosine are associated with relapse. The inclusion criteria were (in accordance with EAU 2017) as follows: histopathologically verified adenocarcinoma in prostate biopsy cores or specimens from transurethral resection of the prostate (TURP) or prostatectomy for benign prostatic enlargement (BPE) with retained ability to urinate...
September 12, 2018: Cancer Medicine
Kai Wang, Xinguang Chen, Travis A Gerke, Victoria Y Bird, Hans K Ghayee, Mattia Prosperi
BACKGROUND: Dynamic longitudinal patterns in body mass index (BMI) have been suggested to better predict health outcomes than static measures. Effects of BMI trajectories on prostate cancer (PCa) risk have not been thoroughly explored. METHODS: Cohort data were derived from electronic medical records of patients who were admitted to a tertiary-care hospital in the Southeastern USA during 1994-2016. Patients with a history of urologic clinic visit because of any prostatic condition and with repeatedly measured BMI (n = 4857) were included...
September 11, 2018: Cancer Medicine
Annemieke Witteveen, Jan W M Otten, Ingrid M H Vliegen, Sabine Siesling, Judith B Timmer, Maarten J IJzerman
Although personalization of cancer care is recommended, current follow-up after the curative treatment of breast cancer is consensus-based and not differentiated for base-line risk. Every patient receives annual follow-up for 5 years without taking into account the individual risk of recurrence. The aim of this study was to introduce personalized follow-up schemes by stratifying for age. Using data from the Netherlands Cancer Registry of 37 230 patients with early breast cancer between 2003 and 2006, the risk of recurrence was determined for four age groups (<50, 50-59, 60-69, >70)...
September 11, 2018: Cancer Medicine
Sophie K M Heinrichs, Timo Hess, Jessica Becker, Lutz Hamann, Yogesh K Vashist, Katja Butterbach, Thomas Schmidt, Hakan Alakus, Iurii Krasniuk, Aksana Höblinger, Philipp Lingohr, Monika Ludwig, Alexander F Hagel, Claus W Schildberg, Lothar Veits, Ugne Gyvyte, Katharina Weise, Vitalia Schüller, Anne C Böhmer, Julia Schröder, Jan Gehlen, Nicole Kreuser, Sebastian Hofer, Hauke Lang, Florian Lordick, Peter Malfertheiner, Markus Moehler, Oliver Pech, Nikolaos Vassos, Ernst Rodermann, Jakob R Izbicki, Martin Kruschewski, Katja Ott, Ralf R Schumann, Michael Vieth, Elisabeth Mangold, Evita Gasenko, Limas Kupcinskas, Hermann Brenner, Peter Grimminger, Luis Bujanda, Federico Sopeña, Jesús Espinel, Concha Thomson, Ángeles Pérez-Aísa, Rafael Campo, Fernando Geijo, Daniela Collette, Christiane Bruns, Katharina Messerle, Ines Gockel, Markus M Nöthen, Hans Lippert, Karsten Ridwelski, Angel Lanas, Gisela Keller, Michael Knapp, Marcis Leja, Juozas Kupcinskas, Maria A García-González, Marino Venerito, Johannes Schumacher
Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants...
September 6, 2018: Cancer Medicine
Lydia G M van der Geest, Casper H J van Eijck, Bas Groot Koerkamp, Valery E P P Lemmens, Olivier R Busch, Pauline A J Vissers, Johanna W Wilmink, Marc G Besselink
BACKGROUND: Nonresected, nonmetastatic (NR-M0) pancreatic cancer involves both locally advanced pancreatic cancer and patients who did not undergo resection due to poor health status or patient preference. This study investigates nationwide trends of characteristics, treatment, and survival of patients with NR-M0 pancreatic cancer. METHODS: From the Netherlands Cancer Registry, all patients diagnosed with pancreatic cancer between 2006 and 2014 were selected. Chemotherapy and overall survival (OS) of NR-M0 patients were evaluated for 3-year time periods and 2 age groups using chi-square tests for trend and Cox proportional hazard regression analysis...
September 6, 2018: Cancer Medicine
Maria C Katapodi, Katrina R Ellis, Franziska Schmidt, Christos Nikolaidis, Laurel L Northouse
OBJECTIVE: Women diagnosed with breast cancer younger than 45 years (young breast cancer survivors-YBCS) and their biological relatives face significant stressors. Although family support is an important coping resource, little is known about YBCS' and relatives' support and whether it is interdependent. The study described family support in YBCS and their biological relatives; identified demographic, clinical, and psychosocial predictors of support; and determined the interdependence of support in YBCS-relatives family units...
September 5, 2018: Cancer Medicine
Yanyan Lou, Bhagirathbhai Dholaria, Aixa Soyano, David Hodge, Jordan Cochuyt, Rami Manochakian, Stephen J Ko, Mathew Thomas, Margaret M Johnson, Neal M Patel, Robert C Miller, Alex A Adjei, Sikander Ailawadhi
BACKGROUND: Treatment of non-small-cell lung cancer (NSCLC) has been rapidly advancing over the last decade. Academic centers are considered equipped with better expertise. NSCLC outcome trends in novel therapeutic era and impact of initial treatment at academic centers have not been reported. METHODS: The National Cancer Database (NCDB) was used to identify NSCLC incident cases from 2004 to 2013. Overall survival (OS) was plotted by year of diagnosis and type of initial treatment center, accounting for several factors available in NCDB...
September 2, 2018: Cancer Medicine
Arash O Naghavi, Michelle I Echevarria, Tobin J Strom, Yazan A Abuodeh, Puja S Venkat, Kamran A Ahmed, Stephanie Demetriou, Jessica M Frakes, Youngchul Kim, Julie A Kish, Jeffery S Russell, Kristen J Otto, Christine H Chung, Louis B Harrison, Andy Trotti, Jimmy J Caudell
BACKGROUND: Studies suggest treatment outcomes may vary between high (HVC)- and low-volume centers (LVC). Radiation therapy (RT) for head and neck cancer (HNC) requires weeks of treatment, the inconvenience of which may influence a patient's choice for treatment location. We hypothesized that receipt of RT for HNC at a HVC would influence outcomes compared to patients evaluated at a HVC, but who chose to receive RT at a LVC. METHODS: From 1998 to 2011, 1930 HNC patients were evaluated at a HVC and then treated with RT at either a HVC or LVC...
September 2, 2018: Cancer Medicine
Kai Li, Dan Lu, Yazhou Guo, Changwei Wang, Xiao Liu, Yu Liu, Dezhong Liu
INTRODUCTION: The objective of the study was to identify trends in incidence of adult diffuse gliomas in the United States and evaluate the contribution of age, period, and cohort effects to the trends. METHODS: Using the Surveillance, Epidemiology, and End Results 9 database, primary diffuse glioma patients (≥20 years old) diagnosed from 1973 to 2014 were identified. Incidence trends were analyzed using joinpoint regression and age-period-cohort modeling. RESULTS: Overall, the incidence for adult glioma decreased slowly from 1985 to 2014 (annual percent change [APC] = 0...
September 2, 2018: Cancer Medicine
Hye-Young Song, Hayeon Noh, Soo Young Choi, Sung-Eun Lee, Soo-Hyun Kim, Kyung-Mi Kee, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Ji-Hyung Suh, Seon-Young Yang, Eun-Jung Jang, Jangik I Lee, Dong-Wook Kim
The present study aimed to assess the clinical impact of BCR-ABL1 transcript levels determined at an earlier time point than the 3-month early molecular response (EMR) in chronic-phase chronic myeloid leukemia (CML-CP) patients. BCR-ABL1 transcript levels of CML-CP patients (n = 258; median age, 43 [range, 18-81] years) treated with various tyrosine kinase inhibitors (TKIs) were determined at 4 weeks (28 ± 3 days) and at every 3 months of treatment initiation. At 4 weeks, receiver operating characteristic curves revealed that cutoff values of BCR-ABL1 transcripts for achieving major molecular responses (MMRs) by 12 and 60 months were 40...
August 31, 2018: Cancer Medicine
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