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Cancer Medicine

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https://www.readbyqxmd.com/read/28444881/a-three-lncrna-expression-signature-associated-with-the-prognosis-of-gastric-cancer-patients
#1
Peng Song, Bo Jiang, Zhijian Liu, Jie Ding, Song Liu, Wenxian Guan
Long noncoding RNAs (lncRNAs) have emerged as essential players in gene regulation. An ever-increasing number of lncRNAs has been found to be associated with the biogenesis and prognosis of gastric cancer (GC). We aimed to develop an lncRNA signature with prognostic value for survival outcomes of GC. Using an lncRNA mining approach, we analyzed the lncRNA expression profiles of 492 GC patients from the Gene Expression Omnibus (GEO), which consisted of the GSE62254 set (N = 300) and the GSE15459 set (N = 192)...
April 26, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28440066/elevated-glypican-1-expression-is-associated-with-an-unfavorable-prognosis-in-pancreatic-ductal-adenocarcinoma
#2
Haizhen Lu, Fangfei Niu, Fang Liu, Jiajia Gao, Yulin Sun, Xiaohang Zhao
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer in humans, with a 5-year survival rate of <5%. Recently, glypican-1 (GPC1)-expressing circulating exosomes were found to be a promising diagnostic tool for PDAC. However, the aberrant expression of GPC1 has not been systematically evaluated in large-scale clinical samples of PDAC. Here, we performed a comprehensive analysis of GPC1 mRNA and protein expression features. Included in this study were 178 PDAC patients from the cancer genome atlas (TCGA) and 186 subjects whose tissues were used in immunohistochemical staining assays...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28440057/overcoming-linsitinib-intrinsic-resistance-through-inhibition-of-nuclear-factor-%C3%AE%C2%BAb-signaling-in-esophageal-squamous-cell-carcinoma
#3
Junzhou Wu, Kaiyan Chen, Fanrong Zhang, Jiaoyue Jin, Nan Zhang, Dan Li, Lisha Ying, Wei Chen, Herbert Yu, Weimin Mao, Dan Su
The aim of this study is to evaluate the efficacy of insulin-like growth factor 1 receptor (IGF-1R) inhibitor Linsitinib, in esophageal squamous cell carcinoma (ESCC), and to characterize special biomarker to screen Linsitinib-sensitive patients as well as explore the molecular-resistant mechanism to Linsitinib in ESCC. Our study evaluated the sensitivity of insulin-like growth factor 1 receptor (IGF-1R) inhibitor, Linsitinib in ESCC cells with MTT assay. After Linsitinib treatment, the expressions of downstream signaling molecules and apoptosis pathways were measured by western blot...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28440040/hypofractionated-short-course-radiotherapy-in-elderly-patients-with-glioblastoma-multiforme-an-analysis-of-the-national-cancer-database
#4
Kimberley S Mak, Ankit Agarwal, Muhammad M Qureshi, Minh Tam Truong
For elderly patients with glioblastoma multiforme (GBM), randomized trials have shown similar survival with hypofractionated short-course radiotherapy (SCRT) compared to conventionally fractionated long-course radiotherapy (LCRT). We evaluated the adoption of SCRT along with associated factors and survival in a national patient registry. Using the National Cancer Data Base (NCDB), we identified patients aged ≥70 years with GBM, diagnosed between 1998 and 2011, who received SCRT (34-42 Gy in 2.5-3.4 Gy fractions), or LCRT (58-63 Gy in 1...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28440035/mir-145-inhibits-human-colorectal-cancer-cell-migration-and-invasion-via-pak4-dependent-pathway
#5
Nengquan Sheng, Gewen Tan, Weiqiang You, Hongqi Chen, Jianfeng Gong, Di Chen, Huizhen Zhang, Zhigang Wang
MicroRNA-145 (miR-145), as a tumor-suppressive miRNA, has been demonstrated down-regulated in colorectal cancer (CRC) cells, and could inhibit CRC cells growth. However, the molecular pathway in which miR-145 modulates CRC malignant transformation has not been fully revealed. Here, we reported an intense correlation between the expressions of PAK4 and miR-145 in human CRC cell lines. Transwell assay verified overexpression of miR-145, as well as knockdown of PAK4, significantly suppressed cell migration and invasion ability...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28440026/mir-148b-inhibits-glycolysis-in-gastric-cancer-through-targeting-slc2a1
#6
Xiangfu Ding, Jingjing Liu, Tianzhou Liu, Zhiming Ma, Dacheng Wen, Jiaming Zhu
Although the molecular biology of GC has been well characterized, early diagnostic biomarkers and effective therapeutic options in gastric cancer are still under investigation. Here, we found that miR-148b expression decreased in human gastric cancer tissues compared with matched adjacent nontumor tissues by q-PCR analysis and in situ hybridization. Further investigation revealed that overexpression of miR-148b limited glycolysis including glucose consumption, lactate production in gastric cancer cell lines BGC-823 and MKN45...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28440022/mir-372-3p-promotes-cell-growth-and-metastasis-by-targeting-fgf9-in-lung-squamous-cell-carcinoma
#7
Qing Wang, Siyang Liu, Xitong Zhao, Yuan Wang, Dali Tian, Wenjun Jiang
The aim of this study was to study the role of miR-372-3p in lung squamous cell carcinoma (LSCC) cell proliferation and invasion by suppressing FGF9. RT-PCR was used to determine miR-372-3p and FGF9 mRNA expression in tissues and cells. Western blot was used to determine FGF9 expression in tissues and NCI-H520 cell line. Dual luciferase reporter gene assay was conducted to confirm that FGF9 can be directly targeted by miR-372-3p. MTT, colony formation assays were conducted to investigate the effects of ectopic miR-372-3p and FGF9 expression on NCI-H520 cell growth...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28429453/tolcapone-induces-oxidative-stress-leading-to-apoptosis-and-inhibition-of-tumor-growth-in-neuroblastoma
#8
Tyler Maser, Maria Rich, David Hayes, Ping Zhao, Abhinav B Nagulapally, Jeffrey Bond, Giselle Saulnier Sholler
Catechol-O-methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O-methylation. Tolcapone, a drug commonly used in the treatment of Parkinson's disease, is a potent inhibitor of COMT and previous studies indicate that Tolcapone increases the bioavailability of dopamine in cells. In this study, we demonstrate that Tolcapone kills neuroblastoma (NB) cells in preclinical models by inhibition of COMT. Treating four established NB cells lines (SMS-KCNR, SH-SY5Y, BE(2)-C, CHLA-90) and two primary NB cell lines with Tolcapone for 48 h decreased cell viability in a dose-dependent manner, with IncuCyte imaging and Western blotting indicating that cell death was due to caspase-3-mediated apoptosis...
April 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28421677/mindfulness-and-its-efficacy-for-psychological-and-biological-responses-in-women-with-breast-cancer
#9
Elisabeth Kenne Sarenmalm, Lena B Mårtensson, Bengt A Andersson, Per Karlsson, Ingrid Bergh
Many breast cancer survivors have to deal with a variety of psychological and physiological sequelae including impaired immune responses. The primary purpose of this randomized controlled trial was to determine the efficacy of a mindfulness-based stress reduction (MBSR) intervention for mood disorders in women with breast cancer. Secondary outcomes were symptom experience, health status, coping capacity, mindfulness, posttraumatic growth, and immune status. This RTC assigned 166 women with breast cancer to one of three groups: MBSR (8 weekly group sessions of MBSR), active controls (self-instructing MBSR) and non-MBSR...
April 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28414866/characterizing-the-outcomes-of-metastatic-papillary-renal-cell-carcinoma
#10
John Connor Wells, Frede Donskov, Anna P Fraccon, Felice Pasini, Georg A Bjarnason, Benoit Beuselinck, Jennifer J Knox, Sun Young Rha, Neeraj Agarwal, Isaac Alex Bowman, Jae-Lyun Lee, Sumanta K Pal, Sandy Srinivas, Douglas Scott Ernst, Ulka N Vaishampayan, Lori A Wood, Robin Simpson, Guillermo De Velasco, Toni K Choueiri, Daniel Y C Heng
Outcomes of metastatic papillary renal cell carcinoma (pRCC) patients are poorly characterized in the era of targeted therapy. A total of 5474 patients with metastatic renal cell carcinoma (mRCC) in the International mRCC Database Consortium (IMDC) were retrospectively analyzed. Outcomes were compared between clear cell (ccRCC; n = 5008) and papillary patients (n = 466), and recorded type I and type II papillary patients (n = 30 and n = 165, respectively). Overall survival (OS), progression-free survival (PFS), and overall response rate (ORR) favored ccRCC over pRCC...
April 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28411370/nomograms-to-estimate-long-term-overall-survival-and-tongue-cancer-specific-survival-of-patients-with-tongue-squamous-cell-carcinoma
#11
Yun Li, Zhenyan Zhao, Xiaoxiao Liu, Jun Ju, Juan Chai, Qianwei Ni, Chao Ma, Tao Gao, Moyi Sun
The aim of this study was to construct nomograms to predict long-term overall survival (OS) and tongue cancer-specific survival (TCSS) of tongue squamous cell carcinoma (TSCC) patients based on clinical and tumor characteristics. Clinical, tumor, and treatment characteristics of 12,674 patients diagnosed with TSCC between 2004 and 2013 were collected from the Surveillance, Epidemiology, and End Results database. These patients were then divided into surgery and nonsurgery cohorts, and nomograms were developed for each of these groups...
April 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28401704/hif-1%C3%AE-binding-to-aeg-1-promoter-induced-upregulated-aeg-1-expression-associated-with-metastasis-in-ovarian-cancer
#12
Ting Zhao, Chenyan Zhao, Yanting Zhou, Jing Zheng, Shujun Gao, Yuan Lu
Ovarian cancer with the highest mortality rate among gynecological malignancies is one of common cancers among female cancer patients. As reported in recent years, AEG-1 was associated with the occurrence, development, and metastasis of ovarian cancer, but the mechanisms remain unclear. In the current study, invasion capabilities of ovarian cancer OVCAR3 cells were measured by viral infection and transwell assay. Western blot analysis was used to evaluate the expression levels of β-catenin, E-cadherin, MMP2, and MMP9...
April 12, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28401701/presence-of-bone-marrow-micro-metastases-in-stage-i-iii-colon-cancer-patients-is-associated-with-worse-disease-free-and-overall-survival
#13
Carsten T Viehl, Benjamin Weixler, Ulrich Guller, Salome Dell-Kuster, Rachel Rosenthal, Michaela Ramser, Vanessa Banz, Igor Langer, Luigi Terracciano, Guido Sauter, Daniel Oertli, Markus Zuber
The prognostic significance of bone marrow micro-metastases (BMM) in colon cancer patients remains unclear. We conducted a prospective cohort study with long-term follow-up to evaluate the relevance of BMM as a prognostic factor for disease free (DFS) and overall survival (OS) in stage I-III colon cancer patients. In this prospective multicenter cohort study 144 stage I-III colon cancer patients underwent bone marrow aspiration from both iliac crests prior to open oncologic resection. The bone marrow aspirates were stained with the pancytokeratin antibody A45-B/B3 and analyzed for the presence of epithelial tumor cells...
April 12, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28401684/the-effects-of-smoking-status-and-smoking-history-on-patients-with-brain-metastases-from-lung-cancer
#14
Rachel F Shenker, Emory R McTyre, Jimmy Ruiz, Kathryn E Weaver, Christina Cramer, Natalie K Alphonse-Sullivan, Michael Farris, William J Petty, Marcelo R Bonomi, Kounosuke Watabe, Adrian W Laxton, Stephen B Tatter, Graham W Warren, Michael D Chan
There is limited data on the effects of smoking on lung cancer patients with brain metastases. This single institution retrospective study of patients with brain metastases from lung cancer who received stereotactic radiosurgery assessed whether smoking history is associated with overall survival, local control, rate of new brain metastases (brain metastasis velocity), and likelihood of neurologic death after brain metastases. Patients were stratified by adenocarcinoma versus nonadenocarcinoma histologies. Kaplan-Meier analysis was performed for survival endpoints...
April 12, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28401709/the-role-of-microrna-93-regulating-angiopoietin2-in-the-formation-of-malignant-pleural-effusion
#15
Qian Qian, Wenkui Sun, Wen Zhu, Yanan Liu, Ai Ge, Yuan Ma, Yu Zhang, Xiaoning Zeng, Mao Huang
The biological roles of miRNAs in the development of malignant pleural effusion (MPE) are unclear. In this study, the miRNA microarray analysis was performed in two different prognosis groups of lung adenocarcinoma patients. Expression profiles of miRNAs in MPEs were identified. With the help of quantification PCR, we confirmed the expression differences of miRNAs and further analyzed their biological functions and relative target genes in vitro. The target gene of miR-93 was estimated by online database, and also, the protein was tested...
April 11, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28390098/noninvasive-characterization-of-pancreatic-tumor-mouse-models-using-magnetic-resonance-imaging
#16
Navid Farr, Yak-Nam Wang, Samantha D'Andrea, Kayla M Gravelle, Joo Ha Hwang, Donghoon Lee
The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques...
April 7, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28382784/the-impact-of-presence-of-hashimoto-s-thyroiditis-on-diagnostic-accuracy-of-ultrasound-guided-fine-needle-aspiration-biopsy-in-subcentimeter-thyroid-nodules-a-retrospective-study-from-fuscc
#17
Lili Gao, Ben Ma, Li Zhou, Yu Wang, Shuwen Yang, Ning Qu, Yi Gao, Qinghai Ji
The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US-FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US-FNA at FUSCC from December 2012 to November 2015 and followed our criteria were enrolled in this study. We extracted the cytological, pathological, and follow-up US/US-FNA data of patients with subcentimeter nodules. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), false-negative rate (FNR), false-positive rate (FPR), and AUC were calculated to define FNA diagnostic performance in patients...
April 5, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28382702/post-surgery-circulating-free-tumor-dna-is-a-predictive-biomarker-for-relapse-of-lung-cancer
#18
Wenwei Hu, Yang Yang, Longzhen Zhang, Jianxin Yin, Jingwei Huang, Lei Huang, Hua Gu, Gening Jiang, Jianmin Fang
Cancer cells release DNA fragments into plasma as circulating free DNA (cfDNA). However, quantitative measurement of tumor-derived DNA in cfDNA remains challenge. The purpose of this study was to quantitatively assess tumor-derived DNA in lung cancer patients. By optimizing competitive allele-specific TaqMan PCR (CAST-PCR), we assessed the copy number of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) alleles in the pre/post surgery plasma of 168 lung cancer patients...
April 5, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28378539/a-systematic-investigation-of-the-association-between-hpv-and-the-clinicopathological-parameters-and-prognosis-of-oral-and-oropharyngeal-squamous-cell-carcinomas
#19
Fengze Wang, Hui Zhang, Yang Xue, Jiao Wen, Jun Zhou, Xinjie Yang, Jianhua Wei
Human papillomavirus (HPV), the causal factor of cervical cancers, was closely linked to the etiology and prognosis of oropharyngeal squamous cell carcinoma (OPSCC), but its role in oral squamous cell carcinoma (OSCC) was unclear. In addition, few researches based on Chinese population were documented. Hence, we sought to investigate the relationship of HPV marker P16 protein to the clinicopathological parameters and survival of OPSCC and OSCC patients systematically to assess the influence of ethnic, regional difference on HPV susceptibility...
April 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28378527/the-prognostic-value-of-simultaneous-tumor-and-serum-ras-raf-mutations-in-localized-colon-cancer
#20
Caroline Emilie B Thomsen, Ane Lindegaard Appelt, Rikke Fredslund Andersen, Jan Lindebjerg, Lars Henrik Jensen, Anders Jakobsen
The impact of RAS/RAF mutations in localized colon cancer needs clarification. Based on analysis of tumor-specific DNA, this study aimed at elucidating the prognostic influence of mutational status in tumor and serum using an extended panel of mutations. The study retrospectively included 294 patients with curatively resected stage I-III adenocarcinoma of the colon. Mutations in tumor and serum were determined at time of surgery. Analyses were performed with droplet digital PCR technology. Hazard ratio (HR) for the association between mutational status and survival was estimated in multivariate analysis taking known prognostic factors into account...
April 4, 2017: Cancer Medicine
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