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Cancer Medicine

Jingchao Wei, Yu Gan, Dongyi Peng, Xianzhen Jiang, Riko Kitazawa, Yali Xiang, Yingbo Dai, Yuxin Tang, Jianfu Yang
The role of TDRG1 in tumorigenesis and the progression of seminoma, as well as its role in regulating chemosensitivity of seminoma to cisplatin through the PI3K/Akt/mTOR signaling pathway, has been previously defined. However, the detailed mechanism underlying TDRG1 expression and concomitant chemoresistance conditions are unknown. Furthermore, it has been reported that non-protein-coding RNAs play an important role in a variety of vital processes including cellular chemosensitivity. However, the role of non-protein-coding RNAs in regulating the chemosensitivity of seminoma remains unknown...
November 14, 2018: Cancer Medicine
Anli Yang, Weikai Xiao, Dong Chen, Xiaoli Wei, Shanzhou Huang, Ye Lin, Chuanzhao Zhang, Jianwei Lin, Feiwen Deng, Chenglin Wu, Xiaoshun He
BACKGROUND: Vascular invasion, rather than tumor size, was applied into the 7th edition of the AJCC TNM staging system to predict survival of solitary hepatocellular carcinoma (HCC) patients. However, does this mean tumor size is of little value in prognostic prediction? The current study was designed to explore the prognostic ability of tumor sizes in solitary HCC. METHODS: A total of 18 591 patients with solitary HCC categorized as T1 and T2 were retrieved from the Surveillance Epidemiology and End Results (SEER) database...
November 14, 2018: Cancer Medicine
Wei Sun, An-Qi Li, Ping Zhou, Yi-Zhou Jiang, Xi Jin, Yi-Rong Liu, Ya-Jie Guo, Wen-Tao Yang, Zhi-Ming Shao, Xiao-En Xu
DSCAM-AS1 is one of the few intensively studied lncRNAs with high specific expression in luminal breast cancer. It is directly regulated by estrogen receptor α (ERα) and plays vital roles in tumor proliferation, invasion, and tamoxifen resistance. However, the detailed function of DSCAM-AS1 in tumor progression and its clinical significance remain unclear. We reveal that DSCAM-AS1 regulates cell proliferation and colony formation by inducing the G1/S transition. RNA-seq analysis demonstrated that DSCAM-AS1 participates in crucial biological processes, including DNA replication, the G1/S phase transition, sister chromatid cohesion, chromosome segregation, protein localization to the chromosome and DNA recombination...
November 14, 2018: Cancer Medicine
Zhi-Cheng Li, Hongmin Bai, Qiuchang Sun, Yuanshen Zhao, Yanchun Lv, Jian Zhou, Chaofeng Liang, Yinsheng Chen, Dong Liang, Hairong Zheng
PURPOSE: Isocitrate dehydrogenase 1 (IDH1) has been proven as a prognostic and predictive marker in glioblastoma (GBM) patients. The purpose was to preoperatively predict IDH mutation status in GBM using multiregional radiomics features from multiparametric magnetic resonance imaging (MRI). METHODS: In this retrospective multicenter study, 225 patients were included. A total of 1614 multiregional features were extracted from enhancement area, non-enhancement area, necrosis, edema, tumor core, and whole tumor in multiparametric MRI...
November 13, 2018: Cancer Medicine
Ryan D Nipp, Angela C Tramontano, Chung Yin Kong, Chin Hur
BACKGROUND: Little is known about end-of-life care among patients with pancreatic adenocarcinoma (PDAC). We used the Surveillance, Epidemiology, and End Results-Medicare linked database to analyze patterns of hospice use and end-of-life treatment in patients with PDAC. METHODS: We included patients diagnosed with PDAC between 2000-2011 and who had died by December 31, 2012. We assessed patterns of hospice use, chemotherapy receipt, and intensive care unit (ICU) admissions at end-of-life...
November 13, 2018: Cancer Medicine
Theresa Westphal, Gabriel Rinnerthaler, Simon Peter Gampenrieder, Josef Niebauer, Josef Thaler, Michael Pfob, David Fuchs, Marina Riedmann, Barbara Mayr, Bernhard Reich, Thomas Melchardt, Brigitte Mlineritsch, Lisa Pleyer, Richard Greil
BACKGROUND: There is a well-known correlation between obesity, sedentary lifestyle, and breast cancer incidence and outcome. The Arbeitsgemeinschaft Medikamentöse Tumortherapie (AGMT) exercise study was a multicenter, randomized clinical trial and assessed the feasibility and efficacy of physical training in 50 breast cancer patients undergoing aromatase inhibitor treatment. METHODS: Postmenopausal, estrogen receptor-positive breast cancer patients under aromatase inhibitor treatment were randomized 1:1 to counseling and unsupervised training for 48 weeks (unsupervised arm) or counseling and a sequential training (supervised arm) with a supervised phase (24 weeks) followed by unsupervised physical training (further 24 weeks)...
November 10, 2018: Cancer Medicine
Miao Zhang, Ning Han, Yuanjun Jiang, Jie Wang, Gaiyan Li, Xintong Lv, Guang Li, Qiao Qiao
The activation of epidermal growth factor receptor (EGFR) is associated with radioresistance in malignant tumors. Specifically, radiation can destroy endoplasmic reticulum (ER) homeostasis to induce ER stress (ERS). However, the effect of EGFR-mediated regulation of ERS signaling pathway on radiosensitivity has not yet been reported. The present study showed that silencing EGFR increased radiosensitivity of both radiosensitive and radioresistant oropharyngeal squamous cell carcinoma (OSCC) cells by inhibiting ER stress signaling (PERK-eIF2α-GRP94 and IRE1α-XBP1-GRP78)...
November 9, 2018: Cancer Medicine
Nobuhiko Nakagawa, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
BACKGROUND: Advanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database. METHODS: We retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014...
November 8, 2018: Cancer Medicine
Ning An, Wang Jing, Haoyi Wang, Ji Li, Yang Liu, Jinming Yu, Hui Zhu
Brain metastases (BM) are severe incidents in patients with non-small-cell lung cancer (NSCLC). The controversial value of prophylactic cranial irradiation (PCI) in NSCLC in terms of survival benefit prompted us to explore the possible risk factors for BM in NSCLC and identify the potential population most likely to benefit from PCI. Risk factors for brain metastases in NSCLC are reviewed in this article. Identifying patients with a higher risk of BM could possibly increase the benefit of PCI while reducing the discomfort and risks caused by unnecessary invasive procedures in the NSCLC patient population...
November 8, 2018: Cancer Medicine
Ming Yang, Chunsheng Yang, Yingkai Tao, Jianqin Tang, Qian Huang, Wenwen Guo, Shouxin Feng, Aijun Jiang, Xifeng Xu, Guan Jiang, Yanqun Liu
BACKGROUND: Temozolomide (TMZ) is widely used to treat melanoma; however, response rates to TMZ are low because of rapid and frequent resistance. Conditionally, replicative adenoviruses (CRAds) are an effective and promising approach. The receptor for adenovirus is coxsackie-adenovirus receptor (CAR), which is poorly expressed in most cells. However, CD46, which is the receptor of species B adenoviruses (Ads), is highly expressed in many cells. METHODS: We constructed CRAd F5/35-ZD55-IL-24, which uses the viral receptors CAR and CD46 for entry into cells...
November 8, 2018: Cancer Medicine
Fen Xue, Dan Ou, Chaosu Hu, Xiayun He
OBJECTIVE: To observe the local regression and control in T1-2 nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT) and to analyze the related influencing factors. METHODS: Between January 2006 and June 2014, 247 consecutive T1-2 NPC patients treated with IMRT were retrospectively analyzed, with 126 (51.0%) N0-1 disease and 121 (49.0%) N2-3 disease. Among them, 72.9% received platinum-based chemotherapy. The prescribed dose to gross tumor volume was 66 Gy/30 fractions...
November 8, 2018: Cancer Medicine
Vivek Verma, Richard L Sleightholm, Penny Fang, Jeffrey M Ryckman, Chi Lin
BACKGROUND: Esophageal small cell carcinoma (ESCC) is a rare malignancy for which there is no consensus management approach. This is the largest known analysis of nonmetastatic ESCC patients to date, evaluating national practice patterns and outcomes of surgical-based therapy vs chemoradiotherapy (CRT) vs chemotherapy alone. METHODS: The National Cancer Data Base was queried for esophageal cancer patients with histologically confirmed nonmetastatic ESCC. Univariable and multivariable logistic regression ascertained factors associated with receipt of surgical-based management...
November 6, 2018: Cancer Medicine
Yangbo Feng, Yanlu Xiong, Tianyun Qiao, Xiaofei Li, Lintao Jia, Yong Han
Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research. First, we gave an introduction of structure, location, and basic function of LDHA...
November 6, 2018: Cancer Medicine
Tao Lv, Yi-Feng Miao, Ke Jin, Shuo Han, Tian-Qi Xu, Zi-Long Qiu, Xiao-Hua Zhang
Circular RNAs (circRNAs) have been demonstrated to be involved in various biological processes. Nevertheless, the function of circRNAs in medulloblastoma (MB) is still unknown. The present study aimed to investigate the expression profiles of circRNAs and related mechanisms for regulating the proliferation and growth of tumor cells in MB. The expression profiles of circRNAs were screened from four normal cerebellum and four MB samples using a HiSeq Sequencer. Bioinformatic analysis was employed to predict the interaction between circRNAs and mRNAs in MB...
November 6, 2018: Cancer Medicine
Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong Cao, Lingling Zhang, Yingjie Zhang, Jiangang Wang
Purified vitexin compound 1 (VB1, a neolignan isolated and extracted from the seed of Chinese herb Vitex negundo) is an effective antitumor agent and exhibits promising clinical activity against various cancers including colorectal cancer. However, it remains unknown about the precise underlying mechanism associated with the antitumor effect of VB1 and how it triggers apoptosis in cancer cells. Here, we demonstrated that VB1 promoted apoptosis via p53-dependent induction of p53 upregulated modulator of apoptosis (PUMA) and further to induce Bax (Bcl-2-associated X protein) activation and mitochondrial dysfunction in colon cancer HCT-116 and LoVo cells...
November 6, 2018: Cancer Medicine
Tong-Min Wang, Ting Zhou, Yong-Qiao He, Wen-Qiong Xue, Jiang-Bo Zhang, Xiao-Hui Zheng, Xi-Zhao Li, Shao-Dan Zhang, Yi-Xin Zeng, Wei-Hua Jia
BACKGROUND: Several genome-wide association studies (GWASs) have identified strong associations between genetic variants in the human leukocyte antigen (HLA) region and nasopharyngeal carcinoma (NPC). However, given the complex LD pattern in this region, the causal variants and the underlying mechanism of how genetic variants in HLA contribute to NPC development is yet to be understood. METHODS: To systematically characterize the HLA variants and their relationship to NPC susceptibility, we fine-mapped the HLA genes based on the GWAS data of 1583 NPC cases and 972 healthy controls, using SNP2HLA with the Pan-Asian panel as references...
October 30, 2018: Cancer Medicine
Dong-Dong Lin, Xiang-Yang Deng, Dong-Dong Zheng, Cheng-Hui Gu, Li-Sheng Yu, Shang-Yu Xu, Dan-Dong Li, Jun-Hao Fang, Bo Yin, Han-Song Sheng, Jian Lin, Xiao-Lei Zhang, Nu Zhang
BACKGROUND: The update of 2018 NCCN guidelines (central nervous system cancers) recommended the risk classification of postoperative patients diagnosed as adult low-grade (WHO grade II) infiltrative supratentorial astrocytoma/oligodendroglioma (ALISA/O) should take tumor size into consideration. Moreover, the guidelines removed postoperative radiotherapy (PORT) for low risk patients. Our study aimed to explore the specific tumor size to divide postoperative patients into relatively low- or high risk subgroups and the effect of PORT for ALISA/O patients...
October 30, 2018: Cancer Medicine
Omar Abdel-Rahman, Yuan Xu, Patricia A Tang, Richard M Lee-Ying, Winson Y Cheung
BACKGROUND: To describe patterns of referral, consultation, and treatment of advanced pancreatic cancer patients in a population-based health care system and to evaluate the impact of these factors on outcomes. METHODS: This is a retrospective analysis of population-based cancer data from the province of Alberta, Canada. We analyzed patients diagnosed with either locally advanced or metastatic pancreatic adenocarcinoma from 2009 to 2016 and evaluated their patterns of referral to a cancer center, consultation with oncology, and treatment with active anticancer therapies...
October 30, 2018: Cancer Medicine
Xiaohui Duan, Bo Jiang, Jianhui Yang, Lixue Zhou, Bingzhang Tian, Xianhai Mao
OBJECTIVE: Our study aimed to explore the effects of FOXP3 expression on liver neoplasms cells and to further investigate the relationship between FOXP3 and proto-oncogene MYC. METHODS: QRT-PCR was used for assessment of FOXP3 expression in liver neoplasms tissues and para-carcinoma tissues. The effects of FOXP3 on cell viability were determined by CCK8 assay, clone formation experiment, and flow cytometry. For miRNA selection, chips were used to figure out the differentially expressed miRNAs in FOXP3-overexpressing HepG2 cells...
October 30, 2018: Cancer Medicine
Rui Yan, Xuefen Chen, Xiaohuan Gong, Jiwei Wang, Jinming Yu
BACKGROUND: Tooth loss contributes physically and psychologically to health, and quality of life has been a key indicator of the cancer survivors. However, it is less clear whether tooth loss has impact on cancer survivors' quality of life. Our study aimed to investigate the association between tooth loss, toothbrushing, and quality of life in cancer survivors. METHODS: A cross-sectional study was conducted among 9125 cancer survivors in Shanghai, China. Sociodemographic characteristics, frequency of tooth brushing, number of tooth loss were collected using a self-reported questionnaire...
October 30, 2018: Cancer Medicine
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