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Artificial Cells, Nanomedicine, and Biotechnology

Wei Gao, Baoyong Sha, Yuan Zhao, Zhe Fan, Lin Liu, Xin Shen
Propofol lipid emulsion (PLE) is a nanosized sedative, and it is used with a combination of salted antalgic prodrug, fentanyl citrate (FC). To illustrate the synergistic effect of mixing, we compared the sedation/analgesia resulting from simultaneous and sequential administration in surgically induced abortion (No. ChiCTR-IPC-15006153). Simultaneous group showed lower bispectral index, blood pressure, and heart rate, when cannula was inserted into the uterus. It also showed less frequency of hypertension, sinus tachycardia, movement, pain at the injection site, and additional FC...
October 6, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Naghmeh Bahrami, Fatemeh Malekolkottab, Somayeh Ebrahimi-Barough, Zahra Alizadeh Tabari, Jalaleddin Hamisi, Ahmadreza Kamyab, Abdolreza Mohamadnia, Armin Ai, Farshad Bayat, Naeim Bahrami, Jafar Ai
We assessed the effect of purmorphamine along with collagen/hydroxyapatite scaffold in inducing osteogenesis of human endometrial stem cells (hEnSCs). The adhesion, viability, proliferation, and differentiation of cells on scaffold were assayed with SEM, MTT, real time-PCR, and ALP assay, respectively. The results were shown good integration of cells with scaffold. Also, qRT-PCR of differentiated cells shows that osteoblast cell markers are expressed after 21d in 2D and scaffold groups while in the scaffold group the expression of these markers were higher than the 2D group...
September 30, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Narendran Rajendran, Shankar Subramaniam, Mamilla R Charan Raja, Pemaiah Brindha, Santanu Kar Mahapatra, Aravind Sivasubramanian
The present study portrays the isolation of four phenylpropanoids - ferulic acid (FA), sinapic acid (SA), caffeic acid (CA), and chlorogenic acid (CHA) from the water extract of Suaeda maritima (L.) Dumort, a phytochemically less explored Indian medicinal plant. Further, synthesis and characterization of silver and gold nanoparticles using the isolated phenylpropanoids were done. The silver nanoparticles synthesized from S. maritima water extract along with silver nano-conjugated forms of the isolated compounds exhibited appreciable anti-leukemic activity against K562 cells (human myeloid leukemia)...
September 28, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Kadir Erol, Kazım Köse
In this study, negatively charged acrylic acid was used as a functional ligand to synthesise net-poly(2-hydroxyethyl methacrylate-co-acrylic acid) microparticles for the removal of hemoglobin having a positively charged Fe(2+ )ion in the core, as an alternative to conventional techniques to achieve a cost effective high-capacity purification. The characterization of microparticles was performed via Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, the Brunauer - Emmett - Teller surface area analysis, and swelling test methods...
September 23, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Yousef Amini, Bagher Moradi, Mahdi Fasihi-Ramandi
Many materials such as aluminum hydroxide have been tried as adjuvants to compensate low inherent immunogenicity of subunit vaccines. The aim of this study was to evaluate the specific immune response following the administration of aluminum hydroxide nanoparticles with EsxV antigen. The physiochemical properties of the nanoparticle were characterized in vitro. After subcutaneous immunization, cytokine secretion patterns including IFN-gama,IL-4, and TGF-beta levels were measured by indirect enzyme linked immunosorbent assay (ELISA)...
September 20, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Seyed Mohsen Aberoumandi, Majid Mohammadhosseini, Elham Abasi, Sepideh Saghati, Nasrin Nikzamir, Abolfazl Akbarzadeh, Yunes Panahi, Soodabeh Davaran
Cancer is a main public health problem that is known as a malignant tumor and out-of-control cell growth, with the potential to assault or spread to other parts of the body. Recently, remarkable efforts have been devoted to develop nanotechnology to improve the delivery of anticancer drug to tumor tissue as minimizing its distribution and toxicity in healthy tissue. Nanotechnology has been extensively used in the advance of new strategies for drug delivery and cancer therapy. Compared to customary drug delivery systems, nano-based drug delivery method has greater potential in different areas, like multiple targeting functionalization, in vivo imaging, extended circulation time, systemic control release, and combined drug delivery...
September 15, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Marimuthu Govindarajan, Shine Kadaikunnan, Naiyf S Alharbi, Giovanni Benelli
Mosquito control is facing key challenges, including outbreaks of new arbovirus threats. We proposed an eco-friendly synthesis of silver nanoparticles (AgNPs) employing a low-cost extract of Hugonia mystax. AgNPs were specified by UV, XRD, FTIR and EDX spectroscopy, SEM and TEM. AgNPs were more toxic to Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus larvae (LC50: 14.45, 15.86, and 17.46 μg/mL) if compared to aquatic biocontrol organisms Gambusia affinis, Diplonychus indicus, and Anisops bouvieri (LC50: 2567...
September 9, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Sungeun Ahn, Priyanka Singh, Verónica Castro-Aceituno, Shakina Yesmin Simu, Yu-Jin Kim, Ramya Mathiyalagan, Deok-Chun Yang
In the present study, we report that Gold nanoparticles (AuNPs) synthesized using the leaf extract of Panax ginseng Meyer (P.g AuNPs) exert anti-inflammatory effects through inhibition of downstream NF-κB activation in macrophages. We found that P.g AuNPs reduced the expression of the inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PEG2), interleukin (IL)-6, tumor necrosis factor-α (TNF-α) was attenuated by P.g AuNPs. Furthermore, P.g AuNPs suppressed lipopolysaccharide (LPS)-induced activation of NF-κB signaling pathway via p38 mitogen-activated protein kinase (MAPK) in RAW 264...
September 9, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Niyaz Ahmad, Rizwan Ahmad, Atta Abbas Naqvi, Mohammad Ashafaq, Md Aftab Alam, Farhan Jalees Ahmad, Mastour Safer Al-Ghamdi
Antioxidants, with reported neuroprotective activity, encounter free radical induced neural damage leading to reduced risk of cerebral ischemia-reperfusion (IR) injury. Safranal, an antioxidant drug with potential role in the amelioration of cerebral ischemia, endures low solubility and poor absorption property thus resulting a low serum and tissue bioavailability. This research aims to prepare nanoemulsion with the concept; to increase the bioavailability in order to reduce oxidative stress-induced brain injury as well as to evaluate the brain-drug targeting following non-invasive nasal route administration in middle cerebral artery occlusion (MCAO) animal model...
September 9, 2016: Artificial Cells, Nanomedicine, and Biotechnology
A Kanakalakshmi, V Janaki, K Shanthi, S Kamala-Kannan
The aim of this study was to synthesize and characterize Cr(III) nanoparticles using wastewater from electroplating industries and chromium-resistant Bacillus subtilis. Formation of Cr(III) nanoparticles was confirmed by UV-visible (UV-Vis) spectroscopy at 300 nm. The size of the nanoparticles varied from 4 to 50 nm and energy dispersive spectroscopy profile shows strong Cr peak approximately at 4.45 and 5.2 keV. The nanoparticles inhibited the growth of pathogenic bacteria Staphylococcus aureus and Escherichia coli...
September 9, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Wenping Wang, Yaqin Cai, Yanhua Liu, Yunsheng Zhao, Jun Feng, Chen Liu
In this work, microemulsion-based gels were prepared for transdermal delivery of paeonol. Microemulsions containing eutectic mixtures of paeonol and menthol were developed. The obtained microemulsions were evaluated for particle size, viscosity and physical stability. The selected microemulsions were incorporated into Carbopol gels. Drug crystallization behavior during a short-term storage was compared and in vitro permeation and deposition study were conducted on mouse skin. Results showed that the eutectic liquids of paeonol and menthol at all ratio (6:4, 5:5 and 4:6) could form microemulsions but with significantly different physical characteristics...
September 7, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Hina Singh, Juan Du, Tae-Hoo Yi
This study highlights the facile, reliable, cost effective, and ecofriendly synthesis of silver nanoparticles (AgNPs) using Borago officinalis leaves extract efficiently. The biosynthesis of AgNPs was verified by UV-Vis spectrum which showed the surface plasmon resonance (SPR) band at 422 nm. Transmission electron microscope (TEM) analysis revealed that the particles were spherical, hexagonal, and irregular in shape and had size ranging from 30 to 80 nm. The energy dispersive X-ray spectroscopy (EDX) and elemental mapping have displayed the purity and maximum distribution of silver in the AgNPs...
September 6, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Yifan Xu, Wu Xu, Tianyu Lu, Yuxiang Dai, Weibang Liang
We aimed to explore the relationship between miR-126 and glioma. miR-126 was highly expressed in low-grade clinical glioma tissue samples but lowly expressed in high-grade ones (P < .01). A human endogenous miR-126 expression vector was constructed. The migration capacity of cells transfected with the vector significantly decreased (P < .05). Up-regulation of miR-126 suppressed GATA4 protein expression. After transfection, they slightly contracted and became ovally or spherically shaped. F-actin significantly reduced, and microfilaments shortened or disappeared...
September 6, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Bayram Oğuz Özer, Servet Çete
Herein a novel amperometric biosensor based on a conducting polymer with anionic dopant modified electrode was successfully developed for detection of cholesterol. Polypyrrole is deposited on a platinum surface and the sodium dodecylbenzene sulphonate (DBS) ion-doped polypyrrole film was electrochemically prepared by scanning the electrode potential between -0.8 and +0.8 V at a scan rate of 20 mV/s. The present electrochemical biosensor was optimized in terms of working potential, number of cycles, concentrations of monomer, and anionic dopant...
August 30, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Shangyu Xu, Qiongyi Pang, Zhongxiao Lin, Nu Zhang
Intracerebral hemorrhage (ICH) is an important public health problem associated with high mortality and morbidity. The aim of this study was to evaluate the clinical efficacy of integrated traditional Chinese (TCM) and Western medicine (WM) therapy for acute hypertensive ICH. Randomized controlled trials were searched in PubMed, Medline, Embase, Wanfang and CNKI database published between January 2000 and June 2016. Our results showed that integrated TCM and WM therapy appeared to be able to improve the clinical effect for patients with acute hypertensive ICH...
August 28, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Jalil Karnoosh-Yamchi, Mohammad Rahmati-Yamchi, Abolfazl Akbarzadeh, Soodabeh Davaran, Ali Reza Ostad Rahimi, Khalil Garnoosh, Zahra Bahmani, Mohammad Ashoori, Majid Mobasseri
BACKGROUND: There are different methods for insulin administration in diabetic patient. Nano-hydrogel is one of the most talented drug carrier for its sensitivity to environmental stimulus. METHODS AND RESULTS: NIPAAm-MAA-HEM copolymers were synthesized by radical chain reaction. The copolymers were characterized with Scanning electron microscopy (SEM) and Transient electron microscopy (TEM). Copolymers were loaded with regular insulin by modified double emulsion method...
August 18, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Hanady S A Al-Shmgani, Wasnaa H Mohammed, Ghassan M Sulaiman, Ali H Saadoon
Biosynthesis of silver nanoparticles (AgNPs) from Catharanthus roseus leaf extract was carried out, and their characterization, as well as antioxidant, antimicrobial, and wound-healing activities were evaluated. Color change, UV-vis spectrum, XRD, FTIR, and AFM assessments supported the biosynthesis and characterization of AgNPs. The synthesized AgNPs showed strong in vitro antioxidant and antimicrobial activities against various pathogens. The in vivo assessment of wound healing in AgNPs-treated mice revealed their effectiveness in closuring and reducing size of wounds...
August 18, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Xianjie Wen, Xiaohong Li, Hua Liang, Chenxiang Yang, Jiying Zhong, Hanbing Wang, Hongzhen Liu
CaMKIIγ in dorsal root ganglion neurons is closely related to the neuropathic pain, neuron injury induced by local anesthetics. To get great insight into the function of CaMKIIγ in dorsal root ganglion neurons, we need one cell model to specially inhibit the CaMKIIγ mRNA expression. The present study was aimed to establish one cell model to specially inhibit the CaMKIIγ mRNA expression. We designed the CaMKIIγ shRNA sequence and connected with pYr-1.1 plasmid. The ligation product of the CaMKIIγshRNA and pYr-1...
August 16, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Wang Jinling, Sun Sijing, Zhang Jie, Wang Guinian
BACKGROUND: There is an urgent need for novel noninvasive prognostic molecular tumor marker for monitoring the recurrence of breast cancer. MicroRNA-21 (miR-21) play a crucial role in the progression and aggressiveness of breast cancer, but its prognostic significance for patients with breast cancer remains inconclusive. The aim of this meta-analysis is to summarize the role of circulating miR-21 as a molecular marker in patients with breast cancer. MATERIAL AND METHODS: Eligible studies were searched from the PubMed, EMBASE and Web of Science databases...
August 16, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Jian Dong, Chao Song, Lei Zhang, Xiang Feng, Rui Feng, Qingsheng Lu, Zhiqing Zhao, Junmin Bao, Jian Zhou, Zaiping Jing
As one of the leading reason in morbidity and death in the world, atherosclerosis is usually associated with vessel stenosis, ulceration, and inflammatory cell infiltration. However, the formation mechanism of atheroma plaque is unknown. In this research, we have used bioinformatics tools to identify 118 differential expression genes from a GEO dataset. Besides, we also revealed KYNU as a crucial gene in atheroma plaque development.
August 12, 2016: Artificial Cells, Nanomedicine, and Biotechnology
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