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Artificial Cells, Nanomedicine, and Biotechnology

Lingyan Cao, Xiangjun Kong, Shuxian Lin, Shuang Zhang, Jing Wang, Changsheng Liu, Xinquan Jiang
A promising strategy to accelerate bone generation is to deliver a combination of certain growth factors to the integration site via a controlled spatial and temporal delivery mode. Here, a composite hydrogel incorporating poly(lactide-co-glycolide) (PLGA) microspheres was accordingly prepared to load and deliver the osteogenic rhBMP-2 and angiogenic rhVEGF165 in the required manner. In addition, 2-N,6-O-sulphated chitosan (26SCS), which is a synergetic factor of growth factors, was incorporated in the composite hydrogel as well...
September 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Minzhi Zhao, Haiyun Li, Linyang Fan, Yan Ma, He Gong, Wenjia Lai, Qiaojun Fang, Zhiyuan Hu
The first nano-platform commercialized as a drug delivery system was a liposomal formulation. The application of liposome technology resolved the issues of paclitaxel (PTX) insolubility and eliminated the use of solvents causing toxic side-effects, which enabled to apply higher drug doses leading to an enhanced drug efficacy. The growth-inhibitory activity of liposome-encapsulated PTX was retained in vitro against a variety of tumor cell. To investigate the drug efficacy in the system biological level, quantitative proteomic analysis was employed to study the molecular mechanism of the anti-tumor effect of Lipusu® (lip) compared with PTX on lung cancer cell A549...
September 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Anliang Shao, You Ling, Liming Xu, Susu Liu, Changfa Fan, Zhijie Wang, Bin Xu, Chengbin Wang
Homeotransplantation of bones for replacement therapy have been demonstrated reliably in clinical data. However, human donor bones applicable for homeotransplantation are in short supply, which facilitates the search for suitable alternatives, such as xenografts grafts. The α-Gal antigen-related immune risk of xenografts directly affects the safety and effectiveness of the biomaterials and limits their applications in the clinic. The immune risk can be prevented by depletion or breaking anti-Gal antibody prior to transplant...
September 12, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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September 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Xiaolong Tang, Chunmei Xie, Zhenyou Jiang, Amin Li, Shiyu Cai, Changhao Hou, Jian Wang, Yong Liang, Dong Ma
The mTOR signal pathway is often highly activated in B-cell non-Hodgkin's lymphoma (NHL) and promotes cancer progression and chemo-resistance. Therefore, the pathways of mTOR are an important target for drug development in this disease. In the current study, we developed a rituximab (anti-CD20)-modified mTOR inhibitor, AZD-2014, loaded into nanoparticles (Ab-NPs-AZD-2014) for trial of its anti-NHL effect. In a cultured NHL cell line, Ab-NPs-AZD-2014 inhibited cancer cell growth, induced cell apoptosis, and blocked activation of mTORC1 and mTORC2 in Raji cells...
September 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Fei-Ting Hsu, Zung-Hang Wei, Yogi Chang-Yo Hsuan, Willie Lin, Yu-Chin Su, Chia-Hui Liao, Chia-Ling Hsieh
Mesenchymal stem cells (MSCs) that display homing and infiltration properties towards tumor cells are a promising cellular targeting vector for brain tumor therapy but are limited to local-regional delivery in current preclinical models. Here, we investigated whether placenta-derived MSCs (P-MSCs) are a superior cellular vector for systemic targeting of glioblastoma stem-like cells (GSCs), with an imaging modality to real-time monitor the trafficking P-MSCs to glioblastoma sites. Results demonstrated that P-MSCs had greater migratory activity towards GSCs and across blood-brain barrier compared with bone marrow-derived MSCs, and this activity was enhanced by hypoxia precondition...
September 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Drenka Trivanović, Ivana Drvenica, Tamara Kukolj, Hristina Obradović, Ivana Okić Djordjević, Slavko Mojsilović, Jelena Krstić, Branko Bugarski, Aleksandra Jauković, Diana Bugarski
Adipose tissue (AT) homeostasis and expansion are dependent on complex crosstalk between resident adipose stromal/stem cells (ASCs) and AT extracellular matrix (ECM). Although adipose tissue ECM (atECM) is one of the key players in the stem cell niche, data on bidirectional interaction of ASCs and atECM are still scarce. Here, we investigated how atECM guides ASCs' differentiation. atECM altered shape and cytoskeleton organization of ASCs without changing their proliferation, β-galactosidase activity and adhesion...
September 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Shah Zada, Aftab Ahmad, Sikandar Khan, Xinlu Yu, Kun Chang, Arshad Iqbal, Adnan Ahmad, Sadeeq Ullah, Muslim Raza, Ajmal Khan, Shahbaz Ahmad, Pengcheng Fu
Utilizing novel approaches for the green synthesis of metal nanoparticles are of great importance. Therefore, we reported biogenic synthesis of silver nanoparticles (AgNPs) using extracts of Leptolyngbya strain JSC-1, and their significant applications against pathogenic bacteria and cancerous HeLa cell line. The biofabricated AgNPs were characterized by UV-visible spectroscopy, FTIR, SEM, TEM, DLS and zeta-potential. The as prepared AgNPs were assessed for inhibition of bacterial growth and induction of apoptosis in HeLa cells by different doses of AgNPs was evaluated...
September 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Jin-Huan Jiang, Jiang Pi, Hua Jin, Ji-Ye Cai
Graphene oxides (GO) is a promising building material to fabricate desired drug delivery system due to its excellent physicochemical properties. In this study, an innovative nano-drug (Ori@GE11-GO) was constructed based on GE11 peptide functionalized GO for targeted delivery of oridonin to realize the specific recognition of tumour cells and enhance anticancer efficiency. GE11 surface modification onto GO significantly increased the cellular uptake of GO in EGFR overexpressed oesophageal cancer cells (KYSE-30 and EC109 cells) than that of normal cells, indicating the EGFR targeting effects of Ori@GE11-GO...
September 5, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Pinggang Ding, Hongxue Shen, Jianan Wang, Jianming Ju
The aim of this study was to prepare two novel magnolol (MO)-loaded binary mixed micelles (MO-M) using biocompatible copolymers of Soluplus (SOL) and Solutol® HS15 (HS15), SOL and d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS), to improve magnolol's poor solubility and its oral bioavailability. The organic solvent evaporation method was used to obtain two MO-M by optimization; one was prepared by using SOL and HS15 (MO-H), and the other was prepared by using SOL and TPGS (MO-T). The entrapment efficiency (EE%) and drug loading (DL%) of MO-T were 94...
September 5, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Qi Zhang, Xing Huang, Yiqiong Pu, Yaxiong Yi, Tong Zhang, Bing Wang
A novel drug carrier was designed based on a new biomaterial, that is, graphene oxide (GO), to improve the efficiency and specificity of anticancer drug. In this study, GO was successively modified with polyetheramine (PEA) and hyaluronic acid (HA). The carrier was utilized to load an antitumor component, that is, quercetin (Que), which was derived from traditional Chinese medicine, namely the pagoda tree flower bud. This drug delivery system (DDS) exhibited pH sensibility under subacid condition and good biocompatibility even when GO concentration reached 350 μg/mL...
September 5, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Chao Zheng, Xiaoming Shi
Excessive bone resorption induced by abnormal osteoclast differentiation has been associated with bone microstructure damage and bone-associated disorders, including osteoporosis. Here, we investigated the physiological roles of the type 1 cysteinyl leukotriene receptor (cysLTR-1) and the pharmacological functions of the specific cysLTR-1 antagonist montelukast on M-CSF- and RANKL-induced osteoclast differentiation. We showed that cysLTR-1 but not cysLTR-2 is expressed in osteoclast precursor cells: mouse bone marrow-derived macrophages (BMMs)...
September 5, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Ling-Xin Meng, Qiang Ren, Qin Meng, Yu-Xiu Zheng, Mao-Lei He, Shu-Yan Sun, Zhao-Jun Ding, Bing-Cheng Li, Hui-Yun Wang
Untargeted delivery as well as low efficacy are two main obstacles for effective breast cancer therapy. Here in this study, we surface modified silica nanoparticles (SLN) with Trastuzumab (Tra) to construct a tumor-targeting carrier (Tra-SLN) for specific drug delivery to human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer cells. In addition, Tra-SLN could also loaded with broad-spectrum anticancer drug doxorubicin (DOX) to finally construct a drug delivery system (DDS) capable of co-delivering Tra and DOX (Tra-SLN/DOX)...
August 27, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Chia-Hui Chuang, Ruei-Zeng Lin, Juan M Melero-Martin, Ying-Chieh Chen
Timely tissue vascularization and integration of engineered tissues into a patient plays an important role in the successful translation of engineered tissues into clinically relevant therapies. To decrease the time needed to vascularize an engineered adipose tissue, suitable local microenvironments provided by hydrogels to support cell-based functional vascular network formation have been investigated. Using the same biomolecule in solution, two types of hydrogels can be obtained: a "physical hydrogel" which is thermal-induced self-assemble fibril initiation and growth, due to amino and carboxyl telopeptides on collagen chains, and a "chemical hydrogel" which results from the covalently cross-linking of the side chains induced by one step enzyme mediation in aqueous solution...
August 27, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Qiming Shen, Haoyou Wang, Lin Zhang
BACKGROUND: The dysfunction of p53-mediated apoptosis is the key to tumorigenesis, so most gene therapy programs concentrate on improving the expressing level of wild-type p53 in tumour cells. However, the p53 gene therapy has not yielded satisfactory results in tumours with normal p53 function. A new member of p53 gene family-p63, has provided new hopes. TAp63γ (p51A) resembles p53 the most, thus it might become a new promising therapeutic gene of tumours. METHODS: We designed the primer pairs of p51A and amplified the p51A cDNA sequence from human skeletal muscle poly A + RNA to construct recombinant plasmid...
August 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Mehran Alavi, Naser Karimi
Fighting of current antibiotics against multidrug-resistant (MDR) bacteria has not been completely successful. In this study, the bio-synthesized Ag-TiO2 , TiO2 -Ag, Ag-Cu and Cu-Ag nanocomposites (NCs) were used against MDR bacteria including Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 (gram negative) and Staphylococcus aureus ATCC 43300 (gram positive). Antiplanktonic, antibiofilm, antiswarming motility and antiquorum sensing activities of these four NCs were measured by assays of agar well diffusion, minimum inhibition/minimum bactericidal concentrations (MIC/MBC), biofilm formation, biofilm morphology and pyocyanin amounts...
August 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Elham Pishavar, Armin Attaranzadeh, Mona Alibolandi, Mohammad Ramezani, Maryam Hashemi
TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) gene therapy is considered as one of the promising approaches for cancer treatment. Polyamidoamine (PAMAM) is one of the most extensively applied polymeric vector in gene delivery. In the current study, PAMAM (G4 and G5) dendrimers were modified with alkyl-carboxylate chain, PEG and cholesteryl chloroformate in order to enhance transfection efficiency through overcoming extracellular and intracellular barriers while reducing PAMAM cytotoxicity...
August 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Pravin Shende, Jai Vaidya, R S Gaud
Cancer is the largest family of diseases that involve abnormal uncontrolled cell growth which metastasizes to other parts of the body. The most common type of cancers includes lung, liver, colorectal, prostate, stomach, breast and cervical cancer with skin cancer excluding melanoma (contribute up to 40% of the cases). The conventional treatment approaches like surgery, chemotherapy, etc., have several side effects such as severe inflammation and pain. Hence, pharmacotherapeutic approaches of antineoplastic agents can be advantageous for treating various forms of cancer through the skin...
August 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Liya Zhu, Prakash Gangadaran, Senthilkumar Kalimuthu, Ji Min Oh, Se Hwan Baek, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Exosomes are endogenous nanocarriers that can deliver biological information between cells. They are secreted by all cell types, including immune cells such as natural killer (NK) cells. However, mammalian cells release low quantities of exosomes, and the purification of exosomes is difficult. Here, nanovesicles were developed by extrusion of NK cells through filters with progressively smaller pore sizes to obtain exosome mimetics (NK-EM). The anti-tumour effect of the NK-EM was confirmed in vitro and in vivo...
August 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Sen Liu, Si-Dong Yang, Xi-Wei Huo, Da-Long Yang, Lei Ma, Wen-Yuan Ding
OBJECTIVES: This study was aimed to further explore whether estradiol (E2) had protective effects on intervertebral disc degeneration (IVDD) in a rat model. MATERIAL/METHODS: Forty, three-month-old female Sprague Dawley (SD) rats were randomly divided into four groups: Sham, Ovariectomy (OVX), E2 and ICI182780 (ICI). Sham group only underwent the resection of a bit fat; OVX group underwent bilateral ovariectomy; E2 group was treated with E2 based on OVX; ICI group was treated with E2 and pretreated ICI182780 (inhibitor of the estrogen receptor) based on OVX...
July 29, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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