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Artificial Cells, Nanomedicine, and Biotechnology

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https://www.readbyqxmd.com/read/28541828/simple-green-production-of-silver-nanoparticles-facilitated-by-bacterial-genomic-dna-and-their-antibacterial-activity
#1
Jiraporn Chumpol, Sineenat Siri
Green synthesis of AgNPs has gained many research interests as a low cost and eco-friendly approach. This work reported on the use of bacterial genomic DNA as the alternative biopolymer for a green production of AgNPs under a neutral pH. Although both ssDNA and dsDNA could function as stabilizing agents during the synthesis process, the ssDNA, generated by pre-heating the dsDNA at 100 °C, was more efficient to produce AgNPs with higher yield as determined by the intensity of the surface plasmon resonance (SPR) peak of silver at 475 nm...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28541793/inhibition-of-secreted-aspartyl-proteinase-activity-in-biofilms-of-candida-species-by-mycogenic-silver-nanoparticles
#2
Sabahat Hamid, Shama Zainab, Rani Faryal, Naeem Ali, Iqra Sharafat
Candida species are pleomorphic, commensal fungi associated with candidiasis. The extracellular hydrolytic-secreted aspartyl proteinases are recognized as chief agents for pathogenesis of Candida species, involved in the degradation of proteins and adhesion during biofilm formation. This study aimed at exploring inhibitory effect of mycogenic silver nanoparticles (Ag NPs) against C. albicans and non-albicans' biofilm growth and aspartyl proteinase enzyme activity in-vitro. Biofilm forming, drug-resistant clinical isolates of C...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28541761/hydrophilically-modified-self-assembling-%C3%AE-tocopherol-derivative-as-niosomal-nanocarrier-for-improving-clarithromycin-oral-bioavailability
#3
Shafi Ullah, Muhammad Raza Shah, Mohammad Shoaib, Muhammad Imran, Syed Wadood Ali Shah, Farid Ahmed, Qamar Gul, Ismail Shah
Synthesis of biocompatible and cost-effective novel nonionic surfactants from renewable resources has been the subject of greater scientific interest for enhancing the bioavailability of less water-soluble drugs. The present study focuses on the synthesis of α-tocopherol-based novel biocompatible nonionic surfactant and its evaluation for forming clarithromycin-loaded niosomal drug delivery system. α-tocopherol was hydrophilically modified through multistep reactions and characterized using mass and (1)H NMR spectroscopic techniques...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28541741/green-approach-for-synthesis-of-gold-nanoparticles-from-nigella-arvensis-leaf-extract-and-evaluation-of-their-antibacterial-antioxidant-cytotoxicity-and-catalytic-activities
#4
Azam Chahardoli, Naser Karimi, Fatemeh Sadeghi, Ali Fattahi
In the present work, we studied the reduction of gold ions into gold nanoparticles using Nigella arvensis leaf extract in the one-step green synthesis method. The formation of N. arvensis gold nanoparticles (NA-GNPs) was confirmed by UV-Vis spectroscopy, XRD, FT-IR and TEM analyses. The XRD pattern confirmed the crystal structure of NA-GNPs, and TEM image showed the small size (3-37 nm) and almost spherical shape of NA-GNPs. NA-GNPs have not shown enhanced antioxidant properties compared to the plant extract while they were active against the clinical isolated bacterial strains...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28541740/controlling-aedes-albopictus-and-culex-pipiens-pallens-using-silver-nanoparticles-synthesized-from-aqueous-extract-of-cassia-fistula-fruit-pulp-and-its-mode-of-action
#5
Hatem Fouad, Li Hongjie, Dawood Hosni, Jiqian Wei, Ghulam Abbas, Hassan Ga'al, Mo Jianchu
Mosquitoes act as key vector for transmission of devastating parasites and pathogens which affect millions of people globally. In this research, the green synthesis of silver nanoparticles of Cassia fistula fruit pulp as an innovative and operative tool against vector mosquitoes is presented. Silver nanoparticles were characterized by a series of techniques including Fourier transform infrared spectroscopy, Transmission Electron Microscope and confirmed by Scanning Electron Microscope, UV-Vis spectrophotometry and X-ray diffraction...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28532176/synthesis-of-n-alkylated-chitosan-and-its-interactions-with-blood
#6
Yuchen Huang, Yi Zhang, Longbao Feng, Liumin He, Rui Guo, Wei Xue
When hydrophobically modified chitosan (HM-CHI) comes into contact with red blood cells (RBCs), it can cause agglomeration. This property leads HM-CHI to be a potential agent to form a rapid haemostatic plug to stop bleeding at wound sites. In this study, we investigated the properties of the HM-CHI biopolymer to act as an agent that rapidly clots blood. We have examined the synthesis and structural characteristics of HM-CHI - blood substances using X-ray diffraction, infrared spectroscopy and elemental analysis...
May 22, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28521553/glutaraldehyde-polymerized-hemoglobin-and-tempol-polyhb-tempol-has-superoxide-dismutase-activity-that-can-attenuate-oxidative-stress-on-endothelial-cells-induced-by-superoxide-anion
#7
Mengdi Wu, Kun Feng, Qiuhui Li, Huiya Ma, Hongli Zhu, Yudou Xie, Gaofei Yan, Chao Chen, Kunping Yan
A Tempol compound with an amine group (4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, NH2-Tempol) was cross-linked to hemoglobin in a one-step polymerization reaction to produce a novel hemoglobin-based oxygen carrier (HBOC) designated PolyHb-Tempol. The reaction parameters, including the reaction time, pH, temperature, and ratio of reactants, were optimized, and the physiochemical properties of the resulting product were characterized. PolyHb-Tempol didn't show any toxicity towards endothelial cells. Furthermore, from observations of cell morphology and viability, PolyHb-Tempol showed a significant ability to inhibit or eliminate oxidative stress induced by superoxide free radicals...
May 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28521528/prevention-and-control-of-emergent-infectious-disease-with-high-specific-antigen-sensor
#8
Hongzhe Zhang, Shanshan Zhang, Nan Liu
This study aims to evaluate the application of a new type of high specificity antigen sensor in detecting the viruses in sudden infectious diseases. Influenza A (H1N1) virus immunosensor was used for the respective determination of the six kinds of antigens of H1N1, H3N2 viral protein, HA protein of H7N9, influenza B virus, adenovirus, and EV71 virus of same dilution degree on the Screen Printed Carbon Electrode (SPCE), so as to test the specificity of the detection method. In addition, various batches of chick embryo allantoic saliva dilution simulation samples were also detected on their recovery (accuracy), repeatability (precision), and stability...
May 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28513221/sericins-of-mulberry-and-non-mulberry-silkworms-for-eco-friendly-synthesis-of-silver-nanoparticles
#9
Wanna Chaisabai, Arunrat Khamhaengpol, Sineenat Siri
Green synthesis of silver nanoparticles (AgNPs) has received many interests as a simple, cost-effective, and environmentally friendly method. This study reported the use of sericins extracted from non-mulberry (Samia cynthia ricini) and mulberry (Bombyx mori) silkworms for green syntheses of AgNPs. Both sericins possessed the reducing activity, which the reducing activity of S. c. ricini sericin was significantly higher than that of B. mori sericin. The formation of AgNPs facilitated by S. c. ricini sericin was greater than B...
May 17, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28509576/her2-positivity-may-confer-resistance-to-therapy-with-paclitaxel-in-breast-cancer-cell-lines
#10
Navideh Haghnavaz, Faezeh Asghari, Daniel Elieh Ali Komi, Dariush Shanehbandi, Behzad Baradaran, Tohid Kazemi
INTRODUCTION: MicroRNAs (miRNAs) are short non-coding single-stranded RNAs. Involving in post-transcriptional gene silencing, miRNAs are thought to play important roles in many cancers such as breast cancer. Paclitaxel is used widely in the treatment of breast cancer. In this study, we investigated the effect of paclitaxel treatment on the expression levels of two oncomirs (oncomiRs), miR-21 and miR-203, in breast cancer cell lines. MATERIALS AND METHODS: MTT assay was performed to determine IC50 of paclitaxel for human breast cancer cell lines including MCF-7, MDA-MB-231, SKBR3 and BT-474...
May 16, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28509572/effect-of-silibinin-loaded-nano-niosomal-coated-with-trimethyl-chitosan-on-mirnas-expression-in-2d-and-3d-models-of-t47d-breast-cancer-cell-line
#11
Seyede Elmira Yazdi Rouholamini, Saeid Moghassemi, Zahra Maharat, Amirhossien Hakamivala, Susan Kashanian, Kobra Omidfar
Silibinin is a natural flavonoid with a strong antioxidant property and weak cytotoxic activity. It has demonstrated anti-tumoural activity against many types of malignancies; however, due to its hydrophobic structure, it has poor water solubility, bioavailability and permeability across intestinal epithelial cells. To improve the effect of silibinin, we have vehiculated silibinin by a highly stable niosomal nanostructure based on a Span 60/cholesterol (CH)/N-trimethyl chitosan (TMC) system in order to study its potential application for the delivery of silibinin in T47D cultured under three-dimensional (3D) and two-dimensional (2D) conditions...
May 16, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503995/preparation-and-characterization-of-surface-modified-plga-polymeric-nanoparticles-used-to-target-treatment-of-intestinal-cancer
#12
Niyaz Ahmad, Md Aftab Alam, Rizwan Ahmad, Atta Abbas Naqvi, Farhan Jalees Ahmad
Docetaxel (DTX), a cytotoxic taxane, is a poor water-soluble drug and exhibits less oral bioavailability. Current research investigates the effective transport, for DTX-loaded chitosan (CS)-coated-poly-lactide-co-glycolide (PLGA)-nanoparticles (NPs) (DTX-CS-PLGA-NPs) and DTX-PLGA-NPs as well as a novel third-generation P-gp inhibitor i.e. GF120918 (Elacridar), across intestinal epithelium with its successive uptake by the tumour cells in an in vitro model. The prepared NPs showed a spherical shape particle size i...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503994/anti-pseudomonal-and-anti-endotoxic-effects-of-surfactin-stabilized-biogenic-silver-nanocubes-ameliorated-wound-repair-in-streptozotocin-induced-diabetic-mice
#13
Natarajan Krishnan, Balasubramanian Velramar, Rajesh Pandiyan, Rajesh Kannan Velu
Pseudomonas aeruginosa and its lipopolysaccharides play a key role in the pathogenesis of diabetic foot infection, for which, currently no effective therapeutic agents are available. Hence, newer forms of therapeutic agents are required for treating Pseudomonas aeruginosa infection. In this present study, nanocrystalline silver nanoparticles (AgNPs) were synthesized using culture filtrate of Brevibacillus brevis KN8(2) followed by an investigation of its in vivo anti-pseudomonal and anti-endotoxic properties...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503952/hyaluronic-acid-polyethylene-glycol-nanoparticles-for-controlled-delivery-of-mitoxantrone
#14
Azam Sargazi, Naeem Kamali, Fereshteh Shiri, Mostafa Heidari Majd
Hyaluronic acid (HA) has inherent ability to target the CD44 receptors and internalize into tumour cells via receptor-mediated endocytosis. Therefore, conjugation of this natural linear polysaccharide to polymeric NPs or micelles, as one of the most promising approaches, could be useful for future clinical applications such as drug delivery. Accordingly, we report on the synthesis of mitoxantrone (MTX)-conjugated polymeric nanoparticles (NPs) composed of polyethylene glycol-HA (PEG-HA) for MTX delivery toward special tumour cells...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503951/gold-nanoparticles-applications-from-artificial-enzyme-till-drug-delivery
#15
Kazem Golchin, Jafar Golchin, Shahrooz Ghaderi, Neda Alidadiani, Sajjad Eslamkhah, Masoud Eslamkhah, Soodabeh Davaran, Abolfazl Akbarzadeh
Today, nano-medicine promotes new therapeutics and diagnostics tools, including sensing of biomolecules as a biosensor, cancer chemotherapy and drug or gene delivery. Because of small size and biocompatibility of gold nanoparticles (GNPs), they become a good candidate for biological application. Also, thanks to their biological and chemical properties, they can mimic function of some enzymes including super oxide dismutase (SOD), esterase, etc. Also, biomaterials and bioengineering have grown so fast since the last decade for many therapeutic applications such as tissue regeneration...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503949/silymarin-nanoemulsion-against-human-hepatocellular-carcinoma-development-and-optimization
#16
Usama Ahmad, Juber Akhtar, Satya Prakash Singh, Farhan Jalees Ahmad, Sahabjada Siddiqui
OBJECTIVE: Nanoemulsion of silymarin was developed and optimized. MATERIALS AND METHODS: Nanoemulsion was made by aqueous titration method. Sefsol 218 (5.8% v/v), Kolliphor RH40 and polyethylene glycol 400 (Smix; 2:1; 28.99% v/v) were used as oil phase, surfactant and co-surfactant while distilled water (65.22% v/v) acted as an aqueous phase. Nanoemulsion was characterized on the basis of particle size, viscosity, electrical conductivity and refractive index. Further, in vitro release, in vivo pharmacokinetic study, stability study and cancer cell line studies were also performed...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503944/mir-133-involves-in-lung-adenocarcinoma-cell-metastasis-by-targeting-flot2
#17
Guangxia Wei, Yahuan Xu, Tao Peng, Jie Yan
BACKGROUND: Dysregulated microRNAs (miRNAs) reported to involve into the oncogenesis and progression in various human cancers. However, the roles and mechanism of miR-133 in lung adenocarcinoma remain largely unclear. METHODS: In this study, qPCR assay and western blot were used to detect the expression levels of miR-133, Akt and FLOT2. Luciferase reporter assay was used to identify the target role of miR-133 on FLOT2. The cell invasion and the migration capability were performed using the transwell invasion assay and wound healing assay...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503938/design-and-synthesis-of-2-substituted-5-4-trifluoromethylphenyl-sulphonamido-benzoxazole-derivatives-as-human-gst-p1-1-inhibitors
#18
Tugba Ertan-Bolelli, Kayhan Bolelli, Yaman Musdal, Ilkay Yildiz, Esin Aki-Yalcin, Bengt Mannervik, Ismail Yalcin
The glutathione transferases (GSTs) are a family of widely distributed Phase II detoxification enzymes. GST P1-1 is frequently overexpressed in rat and human tumours. It is suggested that overexpression of hGST P1-1 by human tumor cells may play a role in resistance to cancer chemotherapy. Hence, hGST P1-1 can be a promising target for cancer treatment. In this study, new hGST P1-1 inhibitors, 2-(4-substitutedphenyl/benzyl)-5-(4-trifluoromethylphenylsulphonamido) benzoxazole derivatives (Va-Vk) have been designed and synthesized...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28503937/assessment-of-tricalcium-phosphate-collagen-tcp-collagene-nanocomposite-scaffold-compared-with-hydroxyapatite-ha-on-healing-of-segmental-femur-bone-defect-in-rabbits
#19
Mahmoud Mohseni, Alireza Jahandideh, Gholamreza Abedi, Abolfazl Akbarzadeh, Saeed Hesaraki
Bone regeneration is an important objective in clinical practice and has been used for different applications. The aim of this study was to evaluate the effectiveness of nanocomposite tricalcium phosphate (TCP)/collagen scaffolds combined with hydroxyapatite scaffold for bone healing in surgery of femoral defects in rabbits. In this study, 45 mature male New Zealand white rabbits between 6 and 8 months old and weighting between 3 and 3.5 kg were examined. Rabbits were divided into three groups. Surgical procedures were performed after intramuscular injection of Ketamine 10% (ketamine hydrochloride, 50 mg/kg) and Rompun 5% (xylazine, 5 mg/kg)...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28434388/microrna-221-3p-is-up-regulated-and-serves-as-a-potential-biomarker-in-pancreatic-cancer
#20
Feng Li, Jian-Wei Xu, Lei Wang, Han Liu, Ye Yan, San-Yuan Hu
It has been demonstrated that circulating MicroRNAs (miRNAs) could be potential biomarkers for cancer diagnosis and prognosis. For pancreatic cancer (PCa), little is known about miR-221-3p biological function or its prognostic value. In the current study, we profiled miR-221-3p expression in PCa cell lines. Compared with normal pancreases ductal epithelial cells, miR-221-3p is up-regulated in all PCa cell lines analysed. In SW1990 cells, overexpression of miR-221-3p increased cell proliferation and inhibited apoptosis, while inhibition of miR-221-3p decreased cell growth rate and promoted apoptosis...
April 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
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