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Artificial Cells, Nanomedicine, and Biotechnology

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https://www.readbyqxmd.com/read/28789586/comparative-study-of-superparamagnetic-iron-oxide-doxorubicin-co-loaded-poly-lactic-co-glycolic-acid-nanospheres-prepared-by-different-emulsion-solvent-evaporation-methods
#1
Jafar Mosafer, Manouchehr Teymouri
Poly (lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for preparation of polymeric biodegradable carriers that shows attractive features and offers possibilities to tune the physicochemical characteristics, drug release properties and biological behaviour of the PLGA-based nanospheres. Double emulsion solvent evaporation methods fail when it comes to encapsulation of highly hydrophilic drugs such as doxorubicin (Dox). The reason for this defect is due to the rapid drug diffusion into the external aqueous phase before solidification of the PLGA nanospheres...
August 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28784039/ecofriendly-synthesis-of-silver-and-gold-nanoparticles-by-euphrasia-officinalis-leaf-extract-and-its-biomedical-applications
#2
Hina Singh, Juan Du, Priyanka Singh, Tae Hoo Yi
Biogenic synthesis of silver (AgNPs) and gold nanoparticles (AuNPs) using aqueous extract of Euphrasia officinalis has been reported. Stable AgNPs and AuNPs were formed on adding aqueous solutions of silver nitrate and chloroauric acid with E. officinalis leaf extract, in 19 min and 2 min, respectively. The synthesis method used in present study was simple, reliable, rapid, cost effective and ecofriendly. The synthesized nanoparticles were characterized with field emission transmission electron microscopy (FE-TEM), elemental mapping, selected area diffraction pattern (SAED), energy-dispersive X-ray spectroscopy (EDS), X-ray diffractometer (XRD), particle size distribution, zeta potential and Fourier-transform infrared spectroscopy (FTIR)...
August 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28783976/mesoporous-silica-nanorods-for-improved-oral-drug-absorption
#3
Nan Zheng, Jing Li, Cheng Xu, Lishi Xu, Sanming Li, Lu Xu
Mesoporous silica nanoparticles (MSNs) have been widely used in biomedical applications. However, most studies have been limited to spherical MSNs, while non-spherical MSNs have never been rigorously studied. In this study, we fabricated mesoporous silica nanospheres (MSNSs) and mesoporous silica nanorods (MSNRs), with different aspect ratios (ARs) but identical surface chemistries to explore the shape effects of MSNs on oral delivery. The results of cellular studies demonstrated that MSNRs exhibited a higher cellular uptake than MSNSs...
August 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28782440/colloidal-synthesis-of-biocompatible-iron-disulphide-nanocrystals
#4
J Santos-Cruz, R E Nuñez-Anita, S A Mayén-Hernández, O Martínez-Alvarez, L S Acosta-Torres, J de la Fuente-Hernández, E Campos-González, M Vega-González, M C Arenas-Arrocena
The aim of this research was to synthesis biocompatible iron disulphide nanocrystals at different reaction temperatures using the colloidal synthesis methodology. Synthesis was conducted at the 220-240 °C range of reaction temperatures at intervals of 5 °C in an inert argon atmosphere. The toxicity of iron disulphide nanocrystals was evaluated in vitro using mouse fibroblast cell line. Two complementary assays were conducted: the first to evaluate cell viability of the fibroblast via an MTT assay and the second to determine the preservation of fibroblast nuclei integrity through DAPI staining, which labels nuclear DNA in fluorescence microscopes...
August 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28782437/a-sensitive-electrochemical-immunosensor-based-on-poly-2-aminobenzylamine-film-modified-screen-printed-carbon-electrode-for-label-free-detection-of-human-immunoglobulin-g
#5
Thitirat Putnin, Watthanachai Jumpathong, Rawiwan Laocharoensuk, Jaroon Jakmunee, Kontad Ounnunkad
This work focuses on fabricating poly(2-aminobenzylamine)-modified screen-printed carbon electrode as an electrochemical immunosensor for the label-free detection of human immunoglobulin G. To selectively detect immunoglobulin G, the anti-immunoglobulin G antibody with high affinity to immunoglobulin G was covalently linked with the amine group of poly(2-aminobenzylamine) film-deposited screen-printed carbon electrode. The selectivity for immunoglobulin G was subsequently assured by being challenged with redox-active interferences and adventitious adsorption did not significantly interfere the analyte signal...
August 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28782391/in-vitro-expansion-of-cd-133-cells-derived-from-umbilical-cord-blood-in-poly-l-lactic-acid-plla-scaffold-coated-with-fibronectin-and-collagen
#6
Maryam Islami, Yousef Mortazavi, Masoud Soleimani, Samad Nadri
CONTEXT: Due to their renewal and potency, umbilical cord blood (UCB) stem cells have the ability to proliferate and serve as an attractive alternative source for bone marrow transplantation. However, insufficient number of haematopoietic stem cells (HSCs) in UCB is still a major constraint in clinical applications. OBJECTIVE: In vitro expansion of stem cells on fibronectin (Fn)-coated poly-L-lactic acid (PLLA) scaffold can be a proper way to overcome this limitation...
August 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28776396/paclitaxel-loaded-nanoparticles-decorated-with-bivalent-fragment-hab18-f-ab-2-and-cell-penetrating-peptide-for-improved-therapeutic-effect-on-hepatocellular-carcinoma
#7
Cheng Jin, Ling Bai, Lemin Lin, Shuangquan Wang, Xiaolong Yin
Hepatocellular carcinoma (HCC) shows low response to most conventional treatment strategies. Therefore, there is an urgent need for new and effective chemotherapies. Nanotechnology gives a dramatic impact on medicine. In this work, paclitaxel loaded nanoparticles (NPs) decorated with bivalent fragment HAb18 F(ab')2 and/or cell penetrating peptide (CPP) were developed and evaluated. NPs were prepared by emulsification-solvent evaporation method and decorated by carbodiimide chemistry. The physicochemical characteristics of NPs (i...
August 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28776395/electrokinetic-potential-stabilization-by-bile-acid-microencapsulating-formulation-of-pancreatic-%C3%AE-cells-cultured-in-high-ratio-poly-l-ornithine-gel-hydrogel-colloidal-dispersion-applications-in-cell-biomaterials-tissue-engineering-and-biotechnological-applications
#8
Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan, Hani Al-Salami
INTRODUCTION: Current trials for β-cell transplantation have been hindered by poor cell viability and function post-transplantation. Recently, electric charges of the microencapsulating formulation carrying β-cells have shown significant effects on cell survival and function. Thus, this study aimed at investigating the effects of electric charge, of novel colloidal formulation containing β-cells, on cell viability, biological activity and insulin release. METHODS: A new formulation, containing high ratios of poly-L-ornithine, suspending electrical-stimulation hydrogel and polystyrene sulphone (1:1:0...
August 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28776393/superiority-of-amino-modified-chiral-mesoporous-silica-nanoparticles-in-delivering-indometacin
#9
Jing Li, Yingyu Guo, Heran Li, Lei Shang, Sanming Li
The present study established indometacin (IMC) delivery system with chiral mesoporous silica nanoparticles (CMSNs) and amino-modified chiral mesoporous silica nanoparticles (Amino-CMSNs) that previously reported as pharmaceutical excipients, and their systemic biological effects, mainly consisting of in vitro drug intestinal permeability, haemolysis assay, in vivo pharmacokinetics, anti-inflammation pharmacodynamics and gastric irritation, were addressed. It turned out that the two IMC delivery systems established by CMSN and Amino-CMSN significantly improved drug intestinal permeability due to the improved drug dissolution caused by conversion of drug crystalline state to amorphous phase...
August 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28758795/extended-release-delivery-of-erlotinib-glutathione-nanosponge-for-targeting-lung-cancer
#10
Mufassir Mushtaque Momin, Zahid Zaheer, Rana Zainuddin, Jaiprakash N Sangshetti
Systemic and uncontrolled administration of erlotinib hydrochloride (ETB) is associated with severe toxicity. A novel targeted and extended release nanosponge (NS) was synthesized from glutathione (GHS) by a one-step reaction between β-cyclodextrin and pyromellitic dianhydride at room temperature for delivery of ETB in lung cancer. Characterization studies were performed using sophisticated instruments. In-vitro release study was performed in the presence of incremental concentrations of GHS which was analyzed using HPLC...
July 31, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28754064/development-and-characterization-dual-responsive-magnetic-nanocomposites-for-targeted-drug-delivery-systems
#11
Lida Ahmadkhani, Abolfazl Akbarzadeh, Mojtaba Abbasian
A drug delivery system based on dual responsive units was developed. An appealing pH- and thermo-responsive triblock terpolymer as the drug carrier was synthesized by RAFT polymerization of N-isopropyl acrylamide and methacrylic acid monomers using PEG-RAFT agent. The Fe3O4 magnetic nanoparticles were synthesized by co-precipitation of Fe salts. Synthesized samples were characterized by FT-IR, XRD, GPC, SEM and TEM. The dual responsive behaviour and self-assembly of the triblock terpolymers in aqueous solution were investigated using UV-vis transmittance and DLS...
July 28, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28754059/disrupting-the-intramolecular-interaction-between-proto-oncogene-c-src-sh3-domain-and-its-self-binding-peptide-ppii-with-rationally-designed-peptide-ligands
#12
Peng Zhou, Shasha Hou, Zhengya Bai, Zhongyan Li, Heyi Wang, Zheng Chen, Yang Meng
Proto-oncogene non-receptor tyrosine protein kinase c-Src has been involved in the development, progression and metastasis of a variety of human cancers. This protein contains two self-binding peptide (SBP) sites separately between the SH3 domain and polyproline-II (PPII) helix and between the SH2 domain and C-terminal phosphorylatable tail (CTPT), which are potential targets of anticancer drugs to regulate the kinase activity. Here, we described an integrated protocol to systematically investigate the structural basis, energetic property and dynamics behaviour of PPII binding to SH3, and to rationally design potent peptide ligands to target the SBP site of SH3-PPII interaction...
July 28, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28754055/wound-healing-activity-of-curcumin-conjugated-to-hyaluronic-acid-in-vitro-and-in-vivo-evaluation
#13
Mrinalini Sharma, Khageswar Sahu, Surya Prakash Singh, Beena Jain
Curcumin is a promising wound healing agent but its clinical application is limited due to hydrophobicity and lack of stability. In this article, we report the results of a study on wound healing efficacy of curcumin conjugated to hyaluronic acid (HA) which is a natural polysaccharide known to influence the healing process. Studies on proliferation, antioxidant activity and scratch wound healing carried out in human keratinocyte cells revealed that HA-conjugated curcumin treatment enhanced cell proliferation, decreased oxidative damage induced by H2O2 and also improved migration of cells in scratch wounds as compared to treatment with native curcumin...
July 28, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28749189/improved-oral-bioavailability-for-lutein-by-nanocrystal-technology-formulation-development-in-vitro-and-in-vivo-evaluation
#14
Daoxiao Chang, Yanni Ma, Guoyu Cao, Jianhuan Wang, Xia Zhang, Jun Feng, Wenping Wang
Lutein is a kind of natural carotenoids possessing many pharmacological effects. The application of lutein was limited mainly due to its low oral bioavailability caused by poor aqueous solubility. Nanocrystal formulation of lutein was developed to improve the oral bioavailability in this study. The nanosuspension was prepared by the anti-solvent precipitation-ultrasonication method and optimized by Box-Behnken design, followed by freeze-drying to obtain lutein nanocrystals. The nanocrystals were characterized on their physical properties, in vitro dissolution and in vivo absorption performance...
July 27, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28743188/nanocomposite-hydrogels-for-cartilage-tissue-engineering-a-review
#15
Nahideh Asadi, Effat Alizadeh, Roya Salehi, Bahar Khalandi, Soodabeh Davaran, Abolfazl Akbarzadeh
The loss of cartilaginous tissues is an important challenge to orthopaedic surgeons. Injury to cartilage tissue due to its properties is along with movement difficulties. Tissue engineering is a developing field that can be used for regeneration or replacement of damaged tissues. In this field, an appropriate scaffold that support the recruitment, adhesion, proliferation and differentiation of cells is necessary. Hydrogels recently considered as materials that resemble the extracellular matrix (ECM) and efficiently replace defective tissues, but they have limited mechanical strength...
July 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28728449/efficiency-and-cytotoxicity-analysis-of-cationic-lipids-mediated-gene-transfection-into-ags-gastric-cancer-cells
#16
Nasrin Gharaati-Far, Mohammad Reza Tohidkia, Alireza Dehnad, Yadollah Omidi
In this effort, we provided comparative study on optimization of transfection conditions for AGS human gastric cancer cell line using two commercial non-liposomal cationic lipids. Using reporter vector pEGFP-N1, transfection efficiency of Attractene™ and X-tremeGENE HP™ transfection reagents in terms of cell densities and DNA/reagent ratios was determined in AGS cells by flow cytometry and fluorescence microscopy. In addition, influence of transfection reagents on direct cytotoxicity and cell viability was respectively, measured using lactate dehydrogenase (LDH) leakage and MTT assays...
July 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28720004/antinociceptive-synergistic-interaction-between-achillea-millefolium-and-origanum-vulgare-l-extract-encapsulated-in-liposome-in-rat
#17
Farshad Hassanzadeh-Kiabi, Babak Negahdari
AIM: This study aims to evaluate the antinociceptive effect of combined Achillea millefolium and Origanum extract encapsulated in liposome. METHODS: The effect of Achillea millefolium and Origanum vulgare L. extract, and their liposome-incorporated form was assessed using 3% formalin test in rat. 12 male Wistar rats, 4 in each group, were used in this study, and increasing doses of Achillea millefolium (31.6, 100, 178, and 316 mg/kg) and Origanum vulgare L. extract (5...
July 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28720002/green-synthesis-of-silver-nanoparticles-using-prosopis-juliflora-bark-extract-reaction-optimization-antimicrobial-and-catalytic-activities
#18
Geeta Arya, R Mankamna Kumari, Nidhi Gupta, Ajeet Kumar, Ramesh Chandra, Surendra Nimesh
In the present study, silver nanoparticles (PJB-AgNPs) have been biosynthesized employing Prosopis juliflora bark extract. The biosynthesis of silver nanoparticles was monitored on UV-vis spectrophotometer. The size, charge and polydispersity index (PDI) of PJB-AgNPs were determined using dynamic light scattering (DLS). Different parameters dictating the size of PJB-AgNPs were explored. Nanoparticles biosynthesis optimization studies suggested efficient synthesis of highly dispersed PJB-AgNPs at 25 °C when 9...
July 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28719999/comparison-of-anticancer-activity-of-biocompatible-zno-nanoparticles-prepared-by-solution-combustion-synthesis-using-aqueous-leaf-extracts-of-abutilon-indicum-melia-azedarach-and-indigofera-tinctoria-as-biofuels
#19
G K Prashanth, P A Prashanth, B M Nagabhushana, S Ananda, G M Krishnaiah, H G Nagendra, H M Sathyananda, C Rajendra Singh, S Yogisha, S Anand, Y Tejabhiram
Recently, there has been an upsurge in the use of naturally available fuels for solution combustion synthesis (SCS) of nanoparticles. Although many reports suggest that these biofuels pose less harm to the environment, their strategic advantages and reliability for making NPs has not been discussed. In the present work, we try to address this issue using plant extracts as biofuels for the SCS of zinc oxide nanoparticles as a model system. In the present work, combustion synthesis of ZnO NPs using lactose and aqueous leaf extracts of Abutilon indicum, Melia azedarach, Indigofera tinctoria as biofuels has been carried out...
July 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28708424/preparation-and-evaluation-of-novel-chitosan-gelrite-ocular-system-containing-besifloxacin-for-topical-treatment-of-bacterial-conjunctivitis-scintigraphy-ocular-irritation-and-retention-assessment
#20
Syed Sarim Imam, Syed Nasir Abbas Bukhari, Asgar Ali
This study was aimed to prepare, characterize and evaluate in situ gel formulations based on a blend of chitosan (CS), polyvinyl alcohol (PVA) and gellan gum (Gelrite™) for a sustained ocular delivery of besifloxacin (BSF). The developed formulations were evaluated for physicochemical properties, gelation time (Tsol-gel), rheological behaviour, antimicrobial efficacy, pharmacokinetic assessment, gamma scintigraphy study and ocular irritation. The results showed BSF sol-gel system were found to be sensitive enough which underwent instantaneous phase transition upon getting physiological stimulation...
July 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
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