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Artificial Cells, Nanomedicine, and Biotechnology

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https://www.readbyqxmd.com/read/28423951/preparation-characterization-and-dynamical-mechanical-properties-of-dextran-coated-iron-oxide-nanoparticles-dionps
#1
Hatice Kaplan Can, Serap Kavlak, Shahed ParviziKhosroshahi, Ali Güner
Dextran-coated iron oxide nanoparticles (DIONPs) with appropriate surface chemistry exhibit many interesting properties that can be exploited in a variety of biomedical applications such as magnetic resonance imaging (MRI) contrast enhancement, tissue repair, hyperthermia, drug delivery and in cell separation. This paper reports the experimental detail for preparation, characterization and investigation of thermal and dynamical mechanical characteristics of the dextran-coated Fe3O4 magnetic nanoparticles. In our work, DIONPs were prepared in a 1:2 ratio of Fe(II) and Fe(III) salt in the HCl solution with NaOH at given temperature...
April 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28423950/hepatoprotective-and-free-radical-scavenging-actions-of-quercetin-nanoparticles-on-a%C3%AF-atoxin-b1-induced-liver-damage-in-vitro-in-vivo-studies
#2
Aziz Eftekhari, Elham Ahmadian, Vahid Panahi-Azar, Hedayat Hosseini, Mahnaz Tabibiazar, Solmaz Maleki Dizaj
The objective of present study was in vitro and in vivo evaluation of hepatoprotective and antioxidant activity of Quercetin nanoparticles (Q NPs) against toxicity induced by aflatoxin B1. The Q NPs were prepared using precipitation method. Hepatocytes were prepared by the method of collagenase enzyme perfusion via portal vein. The NPs were characterized in terms of size and morphology using dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. The level of parameters, such as cell death, ROS formation, lipid peroxidation, mitochondrial membrane potential and cellular glutathione (GSH) content, in the aflatoxin B1-treated and non-treated hepatocytes were determined and the mentioned markers were assessed in the presence of Q NPs...
April 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28423949/intranasal-chitosan-g-hp%C3%AE-cd-nanoparticles-of-efavirenz-for-the-cns-targeting
#3
Aarti Belgamwar, Shagufta Khan, Pramod Yeole
Incompetence of antiretrovirals (ARV) in complete eradication of HIV from the CNS is the biggest issue in neuro-AIDS treatment. The ineffectiveness is largely due to the poor penetration of ARV. Hence, the present study is attempted to enhance the CNS uptake of efavirenz (EFV) by designing intranasal EFV nanoparticles (EFV-NPs). EFV-NPs were fabricated using chitosan-g-HPβCD by ionic gelation method and optimized using quadratic response surface methodology (RSM) employing two-factor, five-level circumscribed central composite design...
April 19, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28423924/advances-in-sirna-delivery-in-cancer-therapy
#4
Aishwarya Singh, Piyush Trivedi, Narendra Kumar Jain
RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to seek cancer cure. siRNA suppress expression of the carcinogenic genes by targeting the mRNA expression. However, in vivo systemic siRNA therapy is hampered by the barriers such as poor cellular uptake, instability under physiological conditions, off-target effects and possible immunogenicity. To overcome these challenges, systemic siRNA therapy warrants the development of clinically suitable, safe, and effective drug delivery systems...
April 19, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28415884/alcohol-quantification-recent-insights-into-amperometric-enzyme-biosensors
#5
Vinita Hooda, Vikas Kumar, Anjum Gahlaut, Vikas Hooda
Biosensors are the switching channels that make sense. The biosensors have found an empirical role in health applications (e.g. clinical diagnostics) as they represent the technological counterpart of living senses. On a global scale, alcohol analysis is indispensable for criminal justice systems, monitoring medical conditions of HIV patients & pregnant women as well as public safety issues regarding pilots, metro drivers, doctors etc. For addressing the clinical and toxicological problems, much advancement in the improvement of biosensors have been witnessed in recent decades...
April 17, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28415882/rage-receptor-targeted-bioconjuguate-lipid-nanoparticles-of-diallyl-disulfide-for-improved-apoptotic-activity-in-triple-negative-breast-cancer-in-vitro-studies
#6
Venkata Talluri Siddhartha, Sai Kiran S S Pindiprolu, Pavan Kumar Chintamaneni, Shashank Tummala, S Nandha Kumar
In the present study, we have demonstrated receptor for advanced glycation endproducts (RAGE) as a target for delivery of drugs specifically to triple negative breast cancer cells. We have prepared solid lipid nanoparticle formulation of cytotoxic agent di-allyl-disulfide (DADS) to overcome its bioavailability issues. Then, we have surface modified DADS-loaded solid lipid nanoparticles (DADS-SLN) with RAGE antibody to achieve site-specific delivery of DADS to TNBC cells. We found a significant cellular internalization of RAGE surface modified DADS-SLN (DADS-RAGE-SLN) when compared to DADS-SLN...
April 17, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28403676/an-overview-application-of-silver-nanoparticles-in-inhibition-of-herpes-simplex-virus
#7
Abolfazl Akbarzadeh, Leila Kafshdooz, Zohre Razban, Ali Dastranj Tbrizi, Shadi Rasoulpour, Rovshan Khalilov, Taras Kavetskyy, Siamak Saghfi, Aygun N Nasibova, Sharif Kaamyabi, Taiebeh Kafshdooz
Nanoscale particles and molecules are a potential different for the treatment of disease because they have distinctive biologic property based on their structure and size, which is different from traditional small-molecule drugs. The antimicrobial mechanisms of silver nanoparticles include the formation of free radicals damaging the bacterial membranes, interactions with DNA, adhesion to cell surface altering the membrane properties, and enzyme damage. In this review, we focus on applications of silver nanoparticles in inhibition of herpes simplex virus...
April 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28403674/haemoglobin-site-specifically-modified-with-ferulic-acid-to-suppress-the-autoxidation
#8
Donglai Qi, Qian Li, Pei Wang, Xiang Wang
Haemoglobin site-specifically modified with ferulic acid (FA-Hb), was synthesized. The effects on the characteristic absorption and the oxygen saturation curve of FA-Hb were investigated by UV-Vis spectrophotometry and oxygen analyzer. Furthermore, the autoxidation rates of Hb and FA-Hb were also discussed with or without sodium azide in the system. The results showed that there was no obvious transformation of the heme structure of FA-Hb. It was also demonstrated that the oxygen-carrying capacity of FA-Hb was similar to the natural Hb, but the autoxidation rate of FA-Hb was much lower than Hb in different systems...
April 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28403666/enhanced-acyclovir-delivery-using-w-o-type-microemulsion-preclinical-assessment-of-antiviral-activity-using-murine-model-of-zosteriform-cutaneous-hsv-1-infection
#9
Amanpreet Kaur, Gajanand Sharma, Vishal Gupta, Radha Kanta Ratho, Om Prakash Katare
The present study was aimed to develop and evaluate a microemulsion-based dermal drug delivery of an antiviral agent, acyclovir. A water-in-oil microemulsion was prepared using isopropyl myristate, Tween 20, Span 20, water and dimethylsulphoxide. It was characterized for drug content, stability, globule size, pH, viscosity and ex vivo permeation through mice skin. In vivo antiviral efficacy of optimized formulation was assessed in female Balb/c mice against herpes simplex virus-I (HSV-I)-induced infection. It was observed that optimized formulation when applied 24-h post-infection could completely inhibit the development of cutaneous herpetic lesions vis-à-vis marketed cream...
April 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28399665/egg-extract-of-apple-snail-for-eco-friendly-synthesis-of-silver-nanoparticles-and-their-antibacterial-activity
#10
Ratima Janthima, Arunrat Khamhaengpol, Sineenat Siri
Green synthesis of silver nanoparticles (AgNPs) provides the alternative method with cost effectiveness and the eco-friendly process by using natural biomolecules as reducing and stabilizing agents. Alternative to the most studies of plant extracts, this work demonstrated a use of egg extract of apple snail (Pomacea canaliculata) for an eco-friendly production of AgNPs. The extract contained at least six proteins with the molecular weight in a range of 24-65 kDa that exhibited the reducing activity. The dispersive AgNPs were produced in the reaction containing only the extract and silver nitrate, as determined by the characteristic surface plasmon resonance peak of silver at 412 nm...
April 11, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28395522/nanotechnology-application-to-local-anaesthesia-la
#11
Mahmoud Reza Moradkhani, Arash Karimi, Babak Negahdari
Several advancements have been made on the exact release of local anaesthetics formulation and its efficiency at inducing motor and sensory block for an extended time has been harnessed in clinical practice. The use of sustained release formulations delivers analgesia for a lengthier period of time with one administration, thereby reducing complications that usually arise with administration of conventional analgesia. In addition, controlled release of an anaesthetic drug is said to prevent overdosing, reduced side effects, especially cardiotoxicity, neurotoxicity and tissue lesions...
April 10, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28395516/nanotechnology-application-for-pain-therapy
#12
Mahmoud Reza Moradkhani, Arash Karimi, Babak Negahdari
Prolonged delivery of analgesic drugs at target sites remains a critical issue for efficient pain management. The use of nano-carriers has been reported to facilitate applicable delivery of these agents to target sites with a reduced level of systemic toxicity. Different analgesics have been loaded onto various nano carriers, including those that are natural, synthetic and copolymer, for various medical applications. In this review, we will discuss the concept of nano-formulated carriers for analgesic drugs and their impacts on the field of pain management...
April 10, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28393563/lipid-nanoparticle-based-co-delivery-of-epirubicin-and-bcl-2-sirna-for-enhanced-intracellular-drug-release-and-reversing-multidrug-resistance
#13
Miao Yu, Shangcong Han, Zhongai Kou, Jialing Dai, Jiao Liu, Chen Wei, Yitong Li, Lutao Jiang, Yong Sun
At present, combined therapy has become an effective strategy for the treatment of cancer. Co-delivery of the chemotherapeutic drugs and siRNA can more effectively inhibit tumor growth by nano drug delivery systems (NDDSs). Here, we prepared and evaluated a multifunctional envelope-type nano device (MEND). This MEND was a kind of composite lipid-nanoparticles possessing both the properties of liposomes and nanoparticles. In this study, an acid-cleavable ketal containing poly (β-amino ester) (KPAE) was used to bind siBCL-2 and the KPAE/siBCL-2 complexes were further coated by epirubicin (EPI) containing lipid to form EPI/siBCL-2 dual loaded lipid-nanoparticles...
April 10, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28393560/evaluating-polyethyleneimine-dna-nanoparticles-mediated-damage-to-cellular-organelles-using-endoplasmic-reticulum-stress-profile
#14
Maryam Dabbaghi, Reza Kazemi Oskuee, Khadijeh Hashemi, Amir Afkhami Goli
Gene therapy has emerged as an influential tool for treating the genetic and specific acquired disorders. Among all kinds of gene delivery systems, the cationic polymer polyethyleneimine (PEI) is considered as a promising non-viral gene delivery vector, although there are still concerns about its magnitude of cytotoxicity. While any cell insult leads to unfolded/misfolded protein accumulation and its consequent unfold protein response, evaluating the expression profile of ER-stress genes would be a sensitive indicator of cell stress...
April 10, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28393568/assessment-of-radical-scavenging-whitening-and-moisture-retention-activities-of-panax-ginseng-berry-mediated-gold-nanoparticles-as-safe-and-efficient-novel-cosmetic-material
#15
Zuly Jiménez, Yeon-Ju Kim, Ramya Mathiyalagan, Kwang-Hoon Seo, Padmanaban Mohanan, Jong-Chan Ahn, Yu-Jin Kim, Deok Chun Yang
Panax ginseng berry extract possess remarkable pharmacological effects on skin treatment such as anti-aging, antioxidant, promotor of collagen synthesis and alleviation against atopic dermatitis. In recent years, gold nanoparticles have gained much attention due to their extensive range of applications in particular in the field of drug delivery as a result of their biological compatibility and low toxicity. In a previous study, we designed and developed biocompatible gold and silver nanoparticles based on phytochemical profile and pharmacological efficacy of P...
April 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28376685/down-regulation-of-microrna-133-predicts-poor-overall-survival-and-regulates-the-growth-and-invasive-abilities-in-glioma
#16
Yu Liu, Lili Han, Yahui Bai, Wei Du, Bo Yang
miRNAs were reported as oncogene or tumour suppressors in various cancers and played important roles in tumour development and progression. Dysregulated miR-133 has been reported in several cancers, however, the expression and biological function of miR-133 in glioma remained unclear. In this study, we found that miR-133 expression level was significantly decreased in glioma tissues and cell lines by RT-qPCR. Then miR-133 mimics were used to evaluate the effects of miR-133 on cell proliferation and invasion in vitro...
April 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28376641/a-comprehensive-mathematical-model-of-drug-release-kinetics-from-nano-liposomes-derived-from-optimization-studies-of-cationic-pegylated-liposomal-doxorubicin-formulations-for-drug-gene-delivery
#17
Fateme Haghiralsadat, Ghasem Amoabediny, Marco N Helder, Samira Naderinezhad, Mohammad Hasan Sheikhha, Tymour Forouzanfar, Behrouz Zandieh-Doulabi
This study focuses on the development of a universal mathematical model for drug release kinetics from liposomes to allow in silico prediction of optimal conditions for fine-tuned controlled drug release. As a prelude for combined siRNA-drug delivery, nanoliposome formulations were optimized using various mole percentages of a cationic lipid (1,2-dioleoyl-3-trimethylammonium-propane, DOTAP) in the presence or absence of 3 mol% distearoyl phosphoethanolamine, polyethylene glycol (PEG-2000mDSPE). Outcome parameters were particle size, zeta potential, entrapment efficiency, in vitro drug release, and tumor cell kill efficiency...
April 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28375753/microniosomes-for-concurrent-doxorubicin-and-iron-oxide-nanoparticles-loading-preparation-characterization-and-cytotoxicity-studies
#18
Behzad Behnam, Mohammad Rezazadehkermani, Saeid Ahmadzadeh, Ahad Mokhtarzadeh, Seyed Noureddin Nematollahi-Mahani, Abbas Pardakhty
The current work deals with developing a suitable drug delivery system of doxorubicin (DOX) for intraperitoneal chemotherapy using niosomes through formulating non-ionic surfactants consisting of Brij™ 52, span™ 60 and Solulan™ C24. Entrapping the magnetite nanoparticles in the hydrophilic parts of niosomes was accompanied with high-efficient DOX loading by the current novel remote-loading method. Cytotoxicity of the prepared formulations was evaluated in vitro against A549 and PC-12 cell lines using the colorimetric WST-1 assay test...
April 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28375686/biological-synthesis-of-gold-and-silver-chloride-nanoparticles-by-glycyrrhiza-uralensis-and-in-vitro-applications
#19
Yue Huo, Priyanka Singh, Yeon Ju Kim, Veronika Soshnikova, Jongpyo Kang, Josua Markus, Sungeun Ahn, Verónica Castro-Aceituno, Ramya Mathiyalagan, Mohan Chokkalingam, Kwi-Sik Bae, Deok Chun Yang
The current study highlights the rapid biosynthesis of gold nanoparticles (Gu-AuNps) and silver chloride nanoparticles (Gu-AgClNps) by aqueous root extract of Glycyrrhiza uralensis, a medicinal plant. G. uralensis has been reported for anticancer and hepatoprotective effects. The reduction of chloroauric acid and silver nitrate by the Glycyrrhiza root extract prompted the formation of Gu-AuNps and Gu-AgClNps within 4 and 40 min at 80 °C, respectively. The complete reaction did not require supplemental reducing and stabilizing agents, which demonstrated green synthesis...
April 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28368661/green-synthesis-of-silver-nanoparticles-using-anthemis-atropatana-extract-characterization-and-in-vitro-biological-activities
#20
Saeede Dehghanizade, Javad Arasteh, Amir Mirzaie
This study aim to synthesize silver nanoparticles (AgNPs) using Anthemis atropatana extract and to evaluate their chemical characteristics and antimicrobial and cytotoxic effects. The biosynthesis of AgNPs is verified using UV-visible spectrum which showing maximum absorption in 430 nm wavelength. Transmission electron microscope (TEM) and scanning electron microscope (SEM) results revealed that AgNPs has a spherical shape with an average size of 38.89 nanometres. The crystalline structure of green synthesized AgNPs in optimal conditions was confirmed by XRD analysis...
April 3, 2017: Artificial Cells, Nanomedicine, and Biotechnology
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