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Translational Neurodegeneration

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https://www.readbyqxmd.com/read/30147869/objective-assessment-of-bradykinesia-in-parkinson-s-disease-using-evolutionary-algorithms-clinical-validation
#1
Chao Gao, Stephen Smith, Michael Lones, Stuart Jamieson, Jane Alty, Jeremy Cosgrove, Pingchen Zhang, Jin Liu, Yimeng Chen, Juanjuan Du, Shishuang Cui, Haiyan Zhou, Shengdi Chen
Background: There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping (FT) that uses evolutionary algorithms (EAs) and explore whether it can be used to identify early stage Parkinson's disease (PD). Methods: One hundred and seven PD, 41 essential tremor (ET) patients and 49 normal controls (NC) were recruited...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30128146/ultra-high-field-diffusion-mri-reveals-early-axonal-pathology-in-spinal-cord-of-als-mice
#2
Rodolfo G Gatto, Manish Y Amin, Daniel Deyoung, Matthew Hey, Thomas H Mareci, Richard L Magin
Background: Amyotrophic lateral sclerosis (ALS) is a disease characterized by a progressive degeneration of motor neurons leading to paralysis. Our previous MRI diffusion tensor imaging studies detected early white matter changes in the spinal cords of mice carrying the G93A-SOD1 mutation. Here, we extend those studies using ultra-high field MRI (17.6 T) and fluorescent microscopy to investigate the appearance of early structural and connectivity changes in the spinal cords of ALS mice...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30128145/dopaminergic-neurons-show-increased-low-molecular-mass-protein-7-activity-induced-by-6-hydroxydopamine-in-vitro-and-in-vivo
#3
Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He, Ping-Yi Xu
Background: Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson's disease (PD). Low-molecular-mass protein 7 (β5i) is a proteolytic subunit of the immunoproteasome that regulates protein degradation and the MHC pathway in immune cells. Methods: In this study, we investigated the role of β5i in DA neurons using a 6-hydroxydopamine (6-OHDA) model in vitro and vivo ...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30065816/properties-of-oscillatory-neuronal-activity-in-the-basal-ganglia-and-thalamus-in-patients-with-parkinson-s-disease
#4
G Du, P Zhuang, M Hallett, Y-Q Zhang, J-Y Li, Y-J Li
Background: The cardinal features of Parkinson's disease (PD) are bradykinesia, rigidity and rest tremor. Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms. This study aims to characterize properties of oscillatory activity in the basal ganglia and motor thalamus in patients with PD. Methods: Twenty-nine patients with PD who underwent bilateral or unilateral electrode implantation for subthalamic nucleus (STN) DBS ( n  = 11), unilateral pallidotomy ( n  = 9) and unilateral thalamotomy (n = 9) were studied...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30062008/the-role-of-substantia-nigra-sonography-in-the-differentiation-of-parkinson-s-disease-and-multiple-system-atrophy
#5
Hai-Yan Zhou, Pei Huang, Qian Sun, Juan-Juan Du, Shi-Shuang Cui, Yun-Yun Hu, Wei-Wei Zhan, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan, Sheng-Di Chen
Background: The differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage. Here, we assessed the value of transcranial sonography (TCS) to discriminate non-tremor dominant (non-TD) PD from MSA with predominant parkinsonism (MSA-P). Methods: Eighty-six MSA-P patients and 147 age and gender-matched non-TD PD patients who had appropriate temporal acoustic bone windows were included in this study...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30038782/cognitive-characteristics-in-chinese-non-demented-pd-patients-based-on-gender-difference
#6
Ke Yang, Bo Shen, Da-Ke Li, Ying Wang, Jue Zhao, Jian Zhao, Wen-Bo Yu, Zhen-Yang Liu, Yi-Lin Tang, Feng-Tao Liu, Huan Yu, Jian Wang, Qi-Hao Guo, Jian-Jun Wu
Background: Cognitive impairment is one of the non-motor symptoms in Parkinson's disease (PD). In the present study, we aim to examine the cognitive function of non-demented Parkinson's disease patients and compare the results between male and female patients as well as control groups in search of any gender effect. Methods: Sixty PD Patients (30 males and 30 females) from the Movement Disorders Clinic at Huashan Hospital Affiliated to Fudan University were recruited to participate in the study...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29988514/adjunct-rasagiline-to-treat-parkinson-s-disease-with-motor-fluctuations-a-randomized-double-blind-study-in-china
#7
Zhenxin Zhang, Ming Shao, Shengdi Chen, Chunfeng Liu, Rong Peng, Yansheng Li, Jian Wang, Suiqiang Zhu, Qiumin Qu, Xiaoying Zhang, Haibo Chen, Xiangru Sun, Yanping Wang, Shenggang Sun, Baorong Zhang, Jimei Li, Xiaoping Pan, Gang Zhao
Background: The use of adjunct rasagiline in levodopa-treated patients with Parkinson's disease and motor fluctuations is supported by findings from large-scale clinical studies. This study is to investigate the efficacy and safety of adjunct rasagiline in Chinese patients with Parkinson's disease, as a product registration study. Methods: This 16-week, randomized, double-blind, parallel-group, multicenter, placebo-controlled study of rasagiline 1 mg/day included levodopa-treated patients with Parkinson's disease and motor fluctuations...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29988485/age-dependent-alpha-synuclein-accumulation-and-aggregation-in-the-colon-of-a-transgenic-mouse-model-of-parkinson-s-disease
#8
Qian-Qian Chen, Caroline Haikal, Wen Li, Ming-Tao Li, Zhan-You Wang, Jia-Yi Li
Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive disease with colonic dysfunction appearing in the prodromal stage and lasting throughout the course of the disease. Methods: In order to study PD pathology in the colon, we examined the age-dependent morphological and pathological changes in the colon of a PD mouse model expressing human wildtype α-synuclein (α-syn) fused with the green fluorescent protein (GFP), under the endogenous mouse α-syn promoter...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29876101/impact-of-the-biological-definition-of-alzheimer-s-disease-using-amyloid-tau-and-neurodegeneration-atn-what-about-the-role-of-vascular-changes-inflammation-lewy-body-pathology
#9
REVIEW
S Gauthier, H Zhang, K P Ng, T A Pascoal, P Rosa-Neto
Background: The NIA-AA research framework proposes a biological definition of Alzheimer's disease, where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms. Discussion: Notwithstanding the fact that amyloid deposition in isolation is not associated with dementia, even the combined association of amyloid and tau pathology does not inevitably need to dementia over age 65. Other pathological factors may play a leading or an accelerating role in age-associated cognitive decline, including vascular small vessel disease, neuroinflammation and Lewy Body pathology...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29719720/chinese-expert-consensus-on-programming-deep-brain-stimulation-for-patients-with-parkinson-s-disease
#10
REVIEW
Shengdi Chen, Guodong Gao, Tao Feng, Jianguo Zhang
Background: Deep Brain Stimulation (DBS) therapy for the treatment of Parkinson's Disease (PD) is now a well-established option for some patients. Postoperative standardized programming processes can improve the level of postoperative management and programming, relieve symptoms and improve quality of life. Main body: In order to improve the quality of the programming, the experts on DBS and PD in neurology and neurosurgery in China reviewed the relevant literatures and combined their own experiences and developed this expert consensus on the programming of deep brain stimulation in patients with PD in China...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29719719/divergent-topological-networks-in-alzheimer-s-disease-a-diffusion-kurtosis-imaging-analysis
#11
Jia-Xing Cheng, Hong-Ying Zhang, Zheng-Kun Peng, Yao Xu, Hui Tang, Jing-Tao Wu, Jun Xu
Background: Brain consists of plenty of complicated cytoarchitecture. Gaussian-model based diffusion tensor imaging (DTI) is far from satisfactory interpretation of the structural complexity. Diffusion kurtosis imaging (DKI) is a tool to determine brain non-Gaussian diffusion properties. We investigated the network properties of DKI parameters in the whole brain using graph theory and further detected the alterations of the DKI networks in Alzheimer's disease (AD). Methods: Magnetic resonance DKI scanning was performed on 21 AD patients and 19 controls...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29713467/cerebral-glucose-metabolic-prediction-from-amnestic-mild-cognitive-impairment-to-alzheimer-s-dementia-a-meta-analysis
#12
REVIEW
Hai Rong Ma, Li Qin Sheng, Ping Lei Pan, Gen Di Wang, Rong Luo, Hai Cun Shi, Zhen Yu Dai, Jian Guo Zhong
Brain 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer's dementia (AD). However, the conversion patterns of FDG-PET metabolism across studies are not conclusive. We conducted a voxel-wise meta-analysis using Seed-based d Mapping that included 10 baseline voxel-wise FDG-PET comparisons between 93 aMCI converters and 129 aMCI non-converters from nine longitudinal studies. The most robust and reliable metabolic alterations that predicted conversion from aMCI to AD were localized in the left posterior cingulate cortex (PCC)/precuneus...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29588852/treating-refractory-depression-in-parkinson-s-disease-a-meta-analysis-of-transcranial-magnetic-stimulation
#13
REVIEW
Alexandra M Lesenskyj, Megan P Samples, Jill M Farmer, Christina R Maxwell
Background: Parkinson's disease (PD) is often accompanied by clinically identified depression. Providing effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to physicians. For this reason, alternatives to standard anti-depressant treatments, such as repetitive transcranial magnetic stimulation (rTMS), have been evaluated within the Parkinson's population. Methods: A literature search was conducted on the PubMed database for all studies that evaluated rTMS as a treatment in patients with both depression and PD...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29568518/exercise-induced-increase-in-brain-derived-neurotrophic-factor-in-human-parkinson-s-disease-a-systematic-review-and-meta-analysis
#14
REVIEW
Mark A Hirsch, Erwin E H van Wegen, Mark A Newman, Patricia C Heyn
Background: Animal models of exercise and Parkinson's disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic factor (BDNF). No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect sizes of individual studies on exercise-induced effects on BDNF blood levels in human PD. Research design and methods: We searched MEDLINE, EMBASE, Cochrane Library, PsycINFO and PubMed from inception to June 2017...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29568517/surfen-and-oxalyl-surfen-decrease-tau-hyperphosphorylation-and-mitigate-neuron-deficits-in-vivo-in-a-zebrafish-model-of-tauopathy
#15
Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J Weiss, Yitzhak Tor, Jeffrey D Esko, Nadia Soussi-Yanicostas
Background: Tauopathies comprise a family of neurodegenerative disorders including Alzheimer's disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by pathological tau hyperphosphorylation, which has been shown to correlate tightly with disease progression and memory loss in patients suffering from Alzheimer's disease. We recently demonstrated an essential requirement for 3- O -sulfated heparan sulfate in pathological tau hyperphosphorylation in zebrafish, a prominent model organism for human drug discovery...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29507718/the-role-of-statins-in-both-cognitive-impairment-and-protection-against-dementia-a-tale-of-two-mechanisms
#16
REVIEW
Bob G Schultz, Denise K Patten, Daniel J Berlau
Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their varied effects on the body. Although randomized controlled trials have not confirmed cognitive impairing effects with statins, continuing evidence suggests statins have the ability to cause reversible cognitive impairment in some patients. Paradoxically, statins have also been shown to decrease the risk of dementia, Alzheimer's disease, and improve cognitive impairment in some cases...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29484176/factors-that-influence-adult-neurogenesis-as-potential-therapy
#17
REVIEW
Belal Shohayeb, Mohamed Diab, Mazen Ahmed, Dominic Chi Hiung Ng
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29456842/hydrogen-sulfide-nitric-oxide-and-neurodegenerative-disorders
#18
REVIEW
Sandesh Panthi, Sumeet Manandhar, Kripa Gautam
Hydrogen Sulfide (H2 S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of the most important regulators of the pathophysiological condition in central nervous system (CNS). It is critical in the various functioning of the brain; however, beyond certain concentration/level, it is toxic. H2 S was regarded as toxic gas with the smell like rotten egg. But, it is now regarded as emerging neuroprotectant and neuromodulator...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29423193/alzheimer-s-disease-hypothesis-and-related-therapies
#19
REVIEW
Xiaoguang Du, Xinyi Wang, Meiyu Geng
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29387348/age-induced-neuronal-cell-death-is-enhanced-in-g2019s-lrrk2-mutation-with-increased-rage-expression
#20
Hyun Jin Cho, Chengsong Xie, Huaibin Cai
Background: Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson's disease (PD). Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD. Advanced glycation end products (AGEs) are produced in high amounts in diabetes and diverse aging-related disorders, such as cardiovascular disease, renal disease, and neurological disease. AGEs trigger intracellular signaling pathway associated with oxidative stress and inflammation as well as cell death...
2018: Translational Neurodegeneration
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