Francesco Londrino, Tito Zattera, Valeria Falqui, Valentina Corbani, Marco Cavallini, Teseo Stefanini, Nadia Chiappini, Michela Ardini, Valentina Martina, Giuseppe Rombolà
We report a case of acute interstitial nephritis (AIN), most likely induced by rosuvastatin, in an 83-year-old male patient. The patient underwent angioplasty of the left internal carotid artery, after which he began a regimen of rosuvastatin (20 mg/day). After 3 weeks the patient was admitted to our unit for acute renal failure with mild proteinuria with negligible urinary sediment. A left kidney biopsy showed dense interstitial infiltrates, mainly composed of lymphocytes with evident tubulitis. Rosuvastatin withdrawal plus prednisolone (1 mg/kg/day) treatment, which was slowly tapered over a period of 4 weeks, allowed for a complete recovery of renal function...
2013: Case Reports in Nephrology and Urology