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Case Reports in Dermatological Medicine

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https://www.readbyqxmd.com/read/28611928/a-case-of-granuloma-annulare-associated-with-secukinumab-use
#1
Lauren Bonomo, Sara Ghoneim, Jacob Levitt
Granuloma annulare (GA) is a benign inflammatory dermatosis characterized clinically by dermal papules and annular plaques. The pathogenesis of GA is not well understood, although it is thought to result from a delayed-type hypersensitivity reaction in which inflammatory cells elicit connective tissue degradation. This condition has been seen following the use of several drugs, including tumor necrosis factor-alpha (TNF-α) inhibitors, which paradoxically have also been reported to treat GA. We report the case of a patient who developed GA in association with secukinumab, an interleukin-17A antagonist, and discuss its implications for our understanding of the pathogenesis of GA...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28567313/puva-induced-bullous-pemphigoid-in-a-patient-with-mycosis-fungoides
#2
Birgül Özkesici, Saliha Koç, Ayşe Akman-Karakaş, Ertan Yılmaz, İbrahim Cumhur Başsorgun, Soner Uzun
Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane. The disease primarily affects the elderly people and in most of the patients inducing factors cannot be identified. Herein, we report a case of BP that occurred in a patient who was receiving PUVA therapy for the treatment of mycosis fungoides. Main Observation. A 26-year-old woman with mycosis fungoides developed blisters while receiving PUVA therapy...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28567312/intracorneal-hematoma-showing-clinical-and-dermoscopic-features-of-acral-lentiginous-melanoma
#3
Ugur Uslu, Franz Heppt, Michael Erdmann
Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28540091/a-severe-case-of-lymphomatoid-papulosis-type-e-successfully-treated-with-interferon-alfa-2a
#4
Aslı Bilgiç Temel, Betül Unal, Hatice Erdi Şanlı, Şeniz Duygulu, Soner Uzun
Lymphomatoid papulosis (LyP) is a benign papulonodular skin eruption with histologic features of malignant lymphoma. A new variant of LyP which was termed "type E" was recently described with similar clinical and histological features to angiocentric and angiodestructive T-cell lymphoma. LyP type E is characterized with recurrent papulonodular lesions which rapidly turn into hemorrhagic necrotic ulcers and spontaneous regression by leaving a scar. None of the available treatment modalities affects the natural course of LyP...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28480085/a-tale-of-two-cysts-steatocystoma-multiplex-and-eruptive-vellus-hair-cysts-two-case-reports-and-a-review-of-the-literature
#5
Rachel J Waldemer-Streyer, Ellen Jacobsen
Background. Steatocystoma multiplex (SM) and eruptive vellus hair cysts (EVHC) are uncommon benign tumors of the pilosebaceous unit. Both SM and EVHC are characterized by smooth, asymptomatic papules or nodules, most commonly presenting on the chest, limbs, and abdomen. Most cases of SM and EVHC are sporadic, although less common autosomal dominant inherited forms have been reported. Main Observation. In this report we present two cases of cutaneous cysts exhibiting characteristics of either SM or EVHC. Both patients presented with numerous 1-2 mm asymptomatic papules and responded well to surgical expression by incision and drainage (I&D)...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28428896/successful-treatment-of-facial-acne-fulminans-antimicrobial-agents-and-oral-prednisolone-as-promising-regimes
#6
Amir Hossein Siadat, Anis Bostakian, Bahareh Abtahi-Naeini, Masoom Shahbazi
Acne fulminans (AF), also known as acne maligna, is a rare painful ulcerative form of acne with an abrupt onset and systemic symptoms. Its incidence appears to be decreasing, possibly because of earlier and better treatment of acne. This report highlights a case on a necrotizing facial wound due to AF that was successfully treated with oral prednisolone and antimicrobial medication.
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28424749/development-of-asymmetric-facial-depigmentation-in-a-patient-treated-with-dasatinib-with-new-onset-hypovitaminosis-d-case-report-and-review-of-the-literature
#7
Kirsten C Webb, Magdalena Harasimowicz, Monica Janeczek, Jodi Speiser, James Swan, Rebecca Tung
Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) used to treat imatinib-resistant chronic myelogenous leukemia (CML), as well as other Philadelphia chromosome-positive lymphoproliferative disorders. While the most commonly reported cutaneous side effects with this therapy include a morbilliform eruption, skin exfoliation, and skin irritation, pigmentary abnormalities have also been observed, albeit much more rarely. We present the case of a 72-year-old South Asian male with CML who presented with new-onset hypopigmentation of his face and scalp three years after a dose increase of dasatinib therapy, in the setting of newly discovered borderline hypovitaminosis D...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28421149/eccrine-nevus-presenting-with-umbilical-discharge-a-case-report-and-review-of-the-literature
#8
Farahnaz Bidari-Zerehpoosh, Shahram Sabeti, Farid Arman, Hania Shakeri
Eccrine nevus is a rare skin lesion with protean manifestations like hyperhidrosis, discolored nodules, papules, and so forth, which has been reported in various anatomic parts of the body including the forearm, leg, thigh, back, and coccyx. Our patient was a 26-year-old male, who presented with increasing colorless and odorless episodic umbilical discharge. First impression for the patient was an umbilical sinus and the patient underwent surgery. Histopathological study revealed the lesion to be an eccrine nevus of the umbilicus...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28348900/unusual-sites-of-cutaneous-tuberculosis-a-report-of-two-cases
#9
Dimple Chopra, Vishal Chopra, Aastha Sharma, Siddharth Chopra, Shivali Aggarwal, Deepak Goyal
Cutaneous tuberculosis (CTB) is an uncommon small subset of extrapulmonary tuberculosis, comprising 1-1.5% of all extrapulmonary tuberculosis manifestations, which manifests only in 8.4-13.7% of all tuberculosis cases. Lupus vulgaris (LV) and tuberculosis verrucosa cutis (TBVC) are forms of reinfection tuberculosis and often occur in presensitized patients, by exogenous inoculation. We report two cases of cutaneous tuberculosis at unusual sites. A 35-year-old female having a forehead lesion for 2 years was diagnosed as having tuberculosis verrucosa cutis and another 16-year-old girl with lesion in left axilla for 10 years was proven to have lupus vulgaris...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28326204/an-unusual-location-of-subungual-warty-dyskeratoma-a-case-report-and-review-of-the-literature
#10
Elena Vargas-Laguna, Adrián Imbernón-Moya, Antonio Aguilar-Martínez, Fernando Burgos
Warty dyskeratoma is an uncommon entity characterized by a solitary keratotic papule or nodule usually located in the head and neck of young adults. The histopathology shows a pattern of acantholytic dyskeratosis. We report a 32-year-old man who presented pain, serous exudation, a distal onycholysis with subungual hyperkeratosis, and roundish erythronychia in the nail plate of his left first toe 2 years ago. A histopathologic diagnosis of subungual warty dyskeratoma was made. When dealing with focal acantholytic dyskeratosis several differential diagnoses should be considered including Darier's disease, transient focal acantholytic dyskeratosis or Grover disease, and Hailey-Hailey disease...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28191356/a-case-of-nonuremic-calciphylaxis-in-a-caucasian-woman
#11
Bonnie Fergie, Nishant Valecha, Andrew Miller
We report a case of nonuremic calcific arteriolopathy (NUCA) in an 82-year-old Caucasian woman from rural Australia. The patient had no history of kidney disease or dialysis. NUCA is rare disease suspected on cutaneous and clinical features and diagnosed by characteristic findings on skin biopsy and vasculature imaging. Calcification induced microvascular occlusion in the absence of renal failure may not be immediately apparent. Clinical suspicion and appropriate investigations are essential for making a diagnosis...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28168063/a-rare-case-of-vancomycin-induced-linear-immunoglobulin-a-bullous-dermatosis
#12
Pinky Jha, Kurtis Swanson, Jeremiah Stromich, Basia M Michalski, Edit Olasz
Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition at the dermoepidermal junction. Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28127475/pseudohypertension-like-presentation-an-exceptionally-rare-presentation-in-an-athletic-female-patient-with-morphea
#13
Ahmed Al-Imam
Introduction. Pseudohypertension is a condition which mainly occurs due to thickening-calcification of tunica intima of the arterial wall, leading to a faulty measurement of the intra-arterial blood pressure. To the best of our knowledge, this is the first case report in literature, of a pseudohypertension-like presentation in association with Morphea en plaque. Case Presentation. This is a rare presentation of a young athletic female and a professional tennis player, with pseudohypertension-like presentation...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28101384/acrokeratosis-paraneoplastica-associated-with-cervical-squamous-cell-carcinoma
#14
Bryan Squires, Steven D Daveluy, Michael C Joiner, Newton Hurst, Michael Bishop, Steven R Miller
Background. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk, elbows, and knees. It is typically associated with upper aerodigestive tract malignancies in males. Rare cases associated with gynecological cancers have been reported, including uterine adenocarcinoma, as well as ovarian and vulvar squamous cell carcinomas...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28074164/radiation-induced-alopecia-after-endovascular-embolization-under-fluoroscopy
#15
Vipawee Ounsakul, Wimolsiri Iamsumang, Poonkiat Suchonwanit
Radiation-induced alopecia after fluoroscopically guided procedures is becoming more common due to an increasing use of endovascular procedures. It is characterized by geometric shapes of nonscarring alopecia related to the area of radiation. We report a case of a 46-year-old man presenting with asymptomatic, sharply demarcated rectangular, nonscarring alopecic patch on the occipital scalp following cerebral angiography with fistula embolization under fluoroscopy. His presentations were compatible with radiation-induced alopecia...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28074163/mycosis-fungoides-of-the-oral-cavity-fungating-tumor-successfully-treated-with-electron-beam-radiation-and-maintenance-bexarotene
#16
Juri Bassuner, Roberto N Miranda, Drew A Emge, Beau A DiCicco, Daniel J Lewis, Madeleine Duvic
Oral involvement in mycosis fungoides is unusual and portends a poor prognosis. The clinical findings of three new cases are described along with a differential diagnosis and review of the literature. For brevity, only one patient is discussed in detail below whereas the other two cases are solely described in table form. The patient had a four-year history of mycosis fungoides before developing an exophytic tongue tumor. He was treated with local electron beam radiation and is disease-free to date while being on maintenance therapy with oral bexarotene...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28050291/unusual-presentation-of-gianotti-crosti-syndrome-due-to-epstein-barr-virus-infection
#17
Hind Saif Al Dhaheri, Amani Al Kaabi, Yasmin Kara Hamo, Aysha Al Kaabi, Salwa Al Kaabi, Hossam Al Tatari
Gianotti-Crosti syndrome (GCS) is viral exanthema of childhood. It typically presents with a symmetric erythematous papular and papulovesicular eruption. It has been classically associated with hepatitis B virus, as well as rarely with Epstein-Barr virus (EBV). We report a case of GCS related to EBV infection without the classical systemic symptoms in a five-year-old male patient.
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28018683/nodular-fasciitis-complicating-a-staged-surgical-excision-of-dermatofibrosarcoma-protuberans
#18
C Helen Malone, Brandon Goodwin, Richard F Wagner, Vicente Resto, Brent Kelly
Dermatofibrosarcoma protuberans (DFSP) is an unusual spindle cell tumor with a high rate of local recurrence with traditional excision. Fortunately, Mohs micrographic surgery yields excellent cure rates for this neoplasm due to contiguous tumor spread and meticulous tumor mapping and margin analysis. We present the unique case of a patient treated with a modified Mohs technique with an analysis of the final margin with permanent sections, who developed a spindle cell neoplasm in the margins of her second stage excision consistent with nodular fasciitis...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/27999691/evolution-of-skin-during-rehabilitation-for-elephantiasis-using-intensive-treatment
#19
Henrique Jose Pereira de Godoy, Ricardo Budtinger Filho, Maria de Fatima Guerreiro Godoy, José Maria Pereira de Godoy
The objective of this study is to describe the evolution of the skin during rehabilitation for elephantiasis using intensive treatment. We report on the case of a 55-year-old patient with a seven-year history of leg edema. The patient reported that it began with repeated outbreaks of erysipelas over several years. One leg evolved with significant edema leading to an inability to ambulate and for about one month the patient said that he could not get out of bed. Moreover the patient was obese weighing 130 kilos and with a BMI of 39...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/27980868/clinical-manifestation-histopathology-and-imaging-of-traumatic-injuries-caused-by-brazilian-porcupine-sphiggurus-villosus-quills
#20
Lívia M Araújo Jorge, Fred Bernardes Filho, Fabrício Lamy, Laila Klotz A Balassiano, Loan Towersey, Roderick Hay, Marco Andrey C Frade
Injuries to humans caused by porcupines are rare. However, they may occur due to the proximity of urban areas and the animal's habitat in areas such as the Floresta da Tijuca in Rio de Janeiro. Outdoor sports and leisure activities in areas close to forests or in the rain forest are also relevant for incidents of this kind and a better knowledge of the local forest fauna would prevent such undesirable accidents. Porcupine quills have microscopic barbs at their tips which facilitate skin penetration, but hampering their removal...
2016: Case Reports in Dermatological Medicine
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