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Case Reports in Dermatological Medicine

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https://www.readbyqxmd.com/read/29682362/upfront-radiotherapy-with-concurrent-and-adjuvant-vismodegib-is-effective-and-well-tolerated-in-a-patient-with-advanced-multifocal-basal-cell-carcinoma
#1
Abigail I Franco, Gary Eastwick, Ramsay Farah, Marvin Heyboer, Mijung Lee, Paul Aridgides
We present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Concurrent treatment was previously reported in the palliative and recurrent setting. This is the first case of concurrent vismodegib and radiation therapy for upfront definitive management. The patient experienced complete response in all treated lesions...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29670773/psoriatic-arthritis-and-nail-psoriasis-in-a-patient-with-concomitant-atopic-dermatitis
#2
Gerhard Eichhoff, Noriko Soffi Harun
Coincidence of psoriasis and atopic dermatitis (AD) is considered to be very rare, as a result of the different underlying immunopathology. This case report describes a patient with long history of atopy and AD who developed psoriatic nail changes and psoriatic arthritis (PsA). The patient's skin, however, revealed only eczematous lesions without manifestation of psoriasis.
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29666714/onychophagia-induced-melanonychia-splinter-hemorrhages-leukonychia-and-pterygium-inversum-unguis-concurrently
#3
Sezin Fıçıcıoğlu, Selma Korkmaz
Onychophagia, which refers to compulsive nail-biting behavior, is common among children and young adults. Onychophagia can cause destruction to the cuticle and nail plate, leading to shortening of nails, chronic paronychia, and secondary infections. Relatively uncommon effects include pigmentary changes, such as longitudinal melanonychia and splinter hemorrhages. We report a case of a young adult with longitudinal melanonychia, splinter hemorrhages, punctate leukonychia, and pterygium inversum unguis, concurrently induced by onychophagia...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29535877/topical-imiquimod-for-the-treatment-of-relapsed-cutaneous-langerhans-cell-histiocytosis-after-chemotherapy-in-an-elderly-patient
#4
Shinsaku Imashuku, Miyako Kobayashi, Yoichi Nishii, Keisuke Nishimura
Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treated with multiagent chemotherapy (cytosine arabinoside/vinblastine/prednisolone). DDAVP also well controlled diabetes insipidus; however, the axillary ulcer and cutaneous LCH relapsed...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29464128/perianal-comedones-a-rare-incidental-finding
#5
Priscilla R Powell, Juana Irma Garza-Chapa, Joseph S Susa, Stephen E Weis
Comedones occur when an overproliferation of keratinocytes blocks sebum secretion in a pilosebaceous duct. Comedones have multiple possible etiologies and contributing factors. While comedones are common to acne, they are also seen in occupational exposures and are associated with certain syndromes. We describe a particularly rare case of comedones at the perianus that is not associated with any known exposure or disease and is a rare incidental finding.
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29430309/a-case-of-disseminated-hypopigmented-keratoses-improved-with-oral-acitretin
#6
Ali Haydar Eskiocak, Cumhur İbrahim Bassorgun, Sarp Uzun, Soner Uzun
Disseminated hypopigmented keratosis is a distinct clinical entity and only few cases have been reported so far. Here, we present a 21-year-old man with almost 10-year history of hypopigmented, nonfollicular, keratotic lichenoid papules occurring on the extensor surfaces of the extremities, back and lumber region. Histopathological examination showed orthohyperkeratosis, irregular acanthosis, and sporadic papillomatosis with a normal amount of melanin and number of melanocytes. In addition, no marked inflammation or melanophages were seen...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29318059/granulosis-rubra-nasi-response-to-topical-tacrolimus
#7
Farhana Tahseen Taj, Divya Vupperla, Prarthana B Desai
Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face, most commonly on the tip of the nose, followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip. It is commonly seen in childhood but it can present in adults. Here we report a case of GRN in an adult patient with very unusual histopathological presentation.
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29234546/repigmentation-of-tenacious-vitiligo-on-apremilast
#8
Sara B Huff, Lorie D Gottwald
Vitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin color. There is no specific serologic marker for diagnosis, but patients often have other autoimmune problems. Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29230331/the-successful-treatment-of-a-case-of-linear-psoriasis-with-ixekizumab
#9
Sara Ghoneim, Alvaro J Ramos-Rodriguez, Fernando Vazquez de Lara, Lauren Bonomo
Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. We report a case of a 25-year-old African-American female who presented with asymptomatic hyperkeratotic papules along the lines of Blaschko and was subsequently diagnosed with linear psoriasis...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29225977/double-morphology-tertiary-syphilis-and-acquired-immunodeficiency-syndrome-a-rare-association
#10
R M Ngwanya, B Kakande, N P Khumalo
Background: Human immunodeficiency virus (HIV) and Treponema pallidum coinfection is relatively common and accounts for about 25% of primary and secondary syphilis. Tertiary syphilis in HIV-uninfected and HIV-infected patients is vanishingly rare. This is most likely due to early treatment of cases of primary and secondary syphilis. There is rapid progression to tertiary syphilis in HIV-infected patients. Case Presentation: A 49-year-old woman diagnosed with HIV Type 1 infection and cluster of differentiation 4 (CD4) count of 482 presented with a four-week history of multiple crusted plaques, nodules, and ulcers on her face, arms, and abdomen...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29209542/skin-lesions-associated-with-nutritional-management-of-maple-syrup-urine-disease
#11
Jaraspong Uaariyapanichkul, Puthita Saengpanit, Ponghatai Damrongphol, Kanya Suphapeetiporn, Sirinuch Chomtho
Introduction: Maple syrup urine disease (MSUD) is an inborn error of branched chain amino acids (BCAAs) metabolism. We report an infant with MSUD who developed 2 episodes of cutaneous lesions as a result of isoleucine deficiency and zinc deficiency, respectively. Case Presentation: A 12-day-old male infant was presented with poor milk intake and lethargy. The diagnosis of MSUD was made based on clinical and biochemical data. Management and Outcome: Specific dietary restriction of BCAAs was given...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29181206/atypical-histiocyte-rich-sweet-s-syndrome
#12
Sharon Chi, Marcia Leung, Mark Carmichael, Michael Royer, Sunghun Cho
Sweet's Syndrome is a rare neutrophilic dermatosis thought to be a result of immune dysregulation occurring in the setting of drug exposure, recent infection, pregnancy, and underlying malignancy or idiopathic with specific and widely accepted diagnostic criteria established in the literature. Other organ systems can be involved with varying degrees of severity. An unusual case of Sweet's Syndrome associated with myopericarditis, acral involvement, and atypical histological findings with predominance of histiocytes is described here...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29181205/basidiobolomycosis-simulating-a-mycobacterium-ulcerans-infection-in-a-togolese-rural-child
#13
Bayaki Saka, Waguena Gnassingbe, Garba Mahamadou, Sefako Akakpo, Julienne Teclessou, Aurel Abilogun-Chokki, Abas Mouhari-Toure, Koussake Kombate, Palokinam Pitché
Background: Basidiobolomycosis is a deep mycosis which preferentially affects rural young people in tropical countries. We report an atypical case, with multiple ulcers, simulating a Buruli ulcer. Case Report: A 5-year-old boy, living in a rural area, was seen for ulcers on the buttocks and at the back and right flank that had been in progress for 4 months. On examination, we found an infiltrated plaque with sharp edges, little painful, located on the buttocks, back, and the right flank...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29147588/diagnostic-challenge-a-report-of-two-adult-onset-still-s-disease-cases
#14
Sakunee Niranvichaiya, Daranporn Triwongwaranat
This study reports two adult-onset Still's disease (AOSD) cases that met both Yamaguchi's and Fautrel's criteria and that presented with notable clinical manifestations. One case presented with atypical dermographism-like rash with an extremely high ferritin level. The other case presented with typical salmon-pink maculopapular rash but had atypical positive rheumatoid factor. This suggests that although negative rheumatoid factor is one of the criteria used for the diagnosis of AOSD, a positive rheumatoid factor result does not exclude AOSD...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29119028/erosive-pustular-dermatosis-of-the-scalp-with-urate-like-crystals
#15
Patrick O Emanuel, Sharad P Paul
Follicular urate-like crystals were first described in Necrotizing Infundibular Crystalline Folliculitis (NICF), a rare cutaneous disorder with multiple waxy folliculocentric papules. Similar crystal accumulation may be seen within follicular infundibulae as an incidental finding. We describe a case showing identical crystals occurring within the horn-like crusts of a patient with erosive pustular dermatosis of the scalp (EPDS), a condition which due to its presentation can often be mistaken for nonmelanoma skin cancer...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29082047/protein-c-deficiency-caused-by-a-novel-mutation-in-the-proc-gene-in-an-infant-with-delayed-onset-purpura-fulminans
#16
Mariam S Al Harbi, Ayman W El-Hattab
Protein C is an anticoagulant that is encoded by the PROC gene. Protein C deficiency (PCD) is inherited in an autosomal dominant or recessive pattern. Autosomal dominant PCD is caused by monoallelic mutations in PROC and often presents with venous thromboembolism. On the other hand, biallelic PROC mutations lead to autosomal recessive PCD which is a more severe disease that typically presents in neonates as purpura fulminans. In this report, we describe an 8-month-old infant with autosomal recessive PCD who presented with multiple lumps on his lower extremities at the age of 2 months and later developed purpura fulminans after obtaining a muscle biopsy from the thigh at the age of 5 months...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29057129/nevus-lipomatosus-superficialis-on-the-left-proximal-arm
#17
Alexander K C Leung, Benjamin Barankin
We report a 58-year-old woman with a solitary type of nevus lipomatosus superficialis on the left proximal arm. To our knowledge, the occurrence of a solitary type of nevus lipomatosus superficialis on the arm has very rarely been reported. A perusal of the literature revealed but one case, to which we are going to add another one. Recognition of this clinical manifestation is important so that a proper diagnosis can be made.
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28912980/sporotrichoid-like-spread-of-cutaneous-mycobacterium-chelonae-in-an-immunocompromised-patient
#18
Daria Marley Kemp, Anusha G Govind, Jun Kang, Caroline C Brugger, Young C Kauh
Mycobacterium chelonae is a rapidly growing mycobacterium found in water and soil that can cause local cutaneous infections in immunocompetent hosts but more frequently affects immunocompromised patients. Typically, patients will present with painful subcutaneous nodules of the joints or soft tissues from traumatic inoculation. However, exhibiting a sporotrichoid-like pattern of these nodules is uncommon. Herein, we report a case of sporotrichoid-like distribution of cutaneous Mycobacterium chelonae in a patient with systemic lupus erythematosus on significant immunosuppressive medications...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28884030/insight-into-natural-history-of-congenital-vitiligo-a-case-report-of-a-23-year-old-with-stable-congenital-vitiligo
#19
Chelsea Casey, Stephen E Weis
Vitiligo is a disorder of skin pigmentation. It affects approximately 1% of the world's population. Vitiligo occurs equally between the sexes with no racial predilections. The majority of cases are acquired and arise between the second and third decades of life. Acquired vitiligo has an unpredictable clinical course. Congenital vitiligo is rare with few reported cases. Due to the rarity of congenital vitiligo, little is known about the clinical course. For patients with acquired or congenital vitiligo, the psychosocial burden can have a profound impact on quality of life...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28831316/pravastatin-induced-eczematous-eruption-mimicking-psoriasis
#20
Michael P Salna, Hannah M Singer, Ali N Dana
BACKGROUND: Statins, an example of the most commonly prescribed medications to the elderly, are not without side effects. Dermatologic events are often overlooked as arising from medications, particularly those which are taken chronically. Moreover, elderly patients are prone to pharmacologic interactions due to multiple medications. In this report, we describe a case of a statin-induced eczematous dermatitis with a psoriasis-like clinical presentation and review the skin manifestations that may arise from statin therapy...
2017: Case Reports in Dermatological Medicine
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