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Dermatology and Therapy

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https://www.readbyqxmd.com/read/28905294/high-patient-satisfaction-with-daylight-activated-methyl-aminolevulinate-cream-in-the-treatment-of-multiple-actinic-keratoses-results-of-an-observational-study-in-australia
#1
Jo-Ann See, Kurt Gebauer, Jason K Wu, Shobhan Manoharan, Nabil Kerrouche, John Sullivan
INTRODUCTION: Actinic keratoses (AK) are treated to reduce the risk of progression to squamous cell carcinoma and for symptomatic and cosmetic benefits. The objective of this observational study was to generate real-life data on the use of daylight photodynamic therapy with methyl aminolevulinate cream (MAL DL-PDT) in treating mild to moderate facial/scalp AK. METHODS: A multicenter, prospective, observational study was conducted in Australia in patients receiving a single treatment of MAL DL-PDT for mild to moderate AK...
September 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28853054/erratum-to-the-burden-of-chronic-urticaria-from-brazilian-patients-perspective
#2
Maria-Magdalena Balp, Nilcéia Lopes da Silva, Jeffrey Vietri, Haijun Tian, Luis F Ensina
No abstract text is available yet for this article.
August 29, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28836173/hpv-47-induced-and-tattoo-associated-verrucae-planae-report-of-a-case-and-review-of-the-literature
#3
Nathalie Krecké, Sigrun Smola, Thomas Vogt, Cornelia Sigrid Lissi Müller
The human papillomavirus (HPV), of which more than 200 different types have so far been identified, is an infectious disease impacting skin and mucous membranes. Several genera exist with distinct clinical impact. However, with ornamental tattoos increasing in popularity, a number of mostly cutaneous side effects have also been reported, such as infections, allergic reactions, or even a rise of malignant tumours within the tattoo. We report the first case of a β1-HPV-type infection in cutaneous lesions in terms of verrucae vulgares near a tattoo in an immunocompetent adult without pre-existing conditions, and discuss possible relationships and etiologic concerns of this association...
August 23, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28815476/long-term-safety-and-effectiveness-of-adalimumab-for-moderate-to-severe-psoriasis-results-from-7-year-interim-analysis-of-the-esprit-registry
#4
Alan Menter, Diamant Thaçi, Jashin J Wu, William Abramovits, Francisco Kerdel, Dilek Arikan, Dianlin Guo, Arijit Ganguli, Mareike Bereswill, Anne Camez, Wendell C Valdecantos
INTRODUCTION: ESPRIT (NCT00799877) is an ongoing 10-year international prospective observational registry evaluating the long-term safety and effectiveness of originator adalimumab in routine clinical practice for adult patients with chronic plaque psoriasis. Herein, we report the long-term safety, effectiveness, and patient-reported outcomes (PROs) following adalimumab treatment over the first 7 years of the ESPRIT registry. METHODS: All treatment-emergent (All-TE) adverse events (AE) since the initial (first ever) dose of adalimumab were assessed...
August 16, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28785924/optimizing-anti-inflammatory-and-immunomodulatory-effects-of-corticosteroid-and-vitamin-d-analogue-fixed-dose-combination-therapy
#5
REVIEW
Siegfried Segaert, Neil H Shear, Andrea Chiricozzi, Diamant Thaçi, Jose-Manuel Carrascosa, Helen Young, Vincent Descamps
Fixed-dose combination topical therapy with corticosteroid and vitamin D analog provides effective treatment and possible long-term management of psoriasis. The anti-inflammatory and immunomodulatory effects of corticosteroids and vitamin D analogs in treating psoriasis are well investigated; their complementary effects lead to the disruption of the inflammatory feedback loop underlying psoriasis pathogenesis. Recent preclinical data showed that combination therapy is more effective than monotherapies of the active ingredients in preventing activation of resting pro-inflammatory cells, inducing immunomodulation, reducing inflammatory responses by regulating T cell production, and normalizing keratinocytes...
August 7, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28748406/therapeutic-effects-of-topical-tranexamic-acid-in-comparison-with-hydroquinone-in-treatment-of-women-with-melasma
#6
Najmolsadat Atefi, Behzad Dalvand, Mahammadreza Ghassemi, Golnaz Mehran, Amir Heydarian
INTRODUCTION: Few studies have focused on therapeutic as well as side effects of tranexamic acid (TXA) as a topical drug compared to other topical drugs in treating melasma. The present study aimed to assess and compare the beneficial therapeutic effects and also side effects of local TXA in comparison with hydroquinone in treating women with melasma. METHODS: This randomized double-blinded clinical trial was performed on 60 women who suffered from melasma and were referred to the skin disorders clinic at the Rasoul-e-Akram hospital in Tehran in 2015...
July 26, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28748405/the-burden-of-chronic-urticaria-from-brazilian-patients-perspective
#7
Maria-Magdalena Balp, Nilcéia Lopes da Silva, Jeffrey Vietri, Haijun Tian, Luis F Esina
INTRODUCTION: Chronic urticaria (CU), a proxy for chronic spontaneous urticaria, has been associated with a negative impact on health-related quality of life (HRQoL) and costs, but there is limited evidence on the burden of CU in Brazil. The objective of this study was to estimate the prevalence of CU and assess the burden of CU on HRQoL and healthcare resource utilization (HRU) among adults in Brazil. METHODS: This retrospective, cross-sectional study, pooled data from the 2011, 2012, and 2015 National Health and Wellness Survey in Brazil (n = 36,000)...
July 26, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28726212/melasma-an-up-to-date-comprehensive-review
#8
REVIEW
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
July 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28710659/comparison-of-the-effect-of-skin-preparation-pads-on-transepidermal-water-loss-in-ex-vivo-human-skin
#9
Hanan Osman-Ponchet, Alexandre Gaborit, Magali Kouidhi, Sandrine Anglars, Jeanne Marceau-Suissa, Orla Duffy-Roger, Jean-Michel Linget, Claire E Wilson
INTRODUCTION: Pre-treatment of the skin to remove scales and crusts prior to photodynamic therapy (PDT) is essential to enhance the uptake of topically applied methyl aminolevulinate (MAL) and to improve treatment efficacy. This study compared the effect of two different skin preparation pads on skin integrity in ex vivo human skin. METHODS: Ex vivo human skin samples from three donors were pre-treated in triplicates with PREPSTER™ (PR) skin preparation pad (6, 8, and 10 passages) or Ambu Unilect™ (A-UN) skin preparation pad (6, 8, and 10 passages)...
July 14, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28707054/frequency-and-management-of-sleep-disturbance-in-adults-with-atopic-dermatitis-a-systematic-review
#10
REVIEW
Caleb Jeon, Di Yan, Mio Nakamura, Sahil Sekhon, Tina Bhutani, Timothy Berger, Wilson Liao
INTRODUCTION: Intense nocturnal pruritus as well as the complex pathophysiology of atopic dermatitis (AD) can severely affect sleep and become a major factor in negatively impacting quality of life in adults. However, much of the literature on sleep disturbance in AD patients is on the pediatric population, and it is not well studied in adults. Furthermore, limited studies are available to guide effective management of sleep disturbance in AD in general. We review the literature to present the studies that have investigated the relationship between AD and its effect on sleep in adults and provide an approach for clinicians caring for this population...
July 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28677110/a-double-blind-randomised-study-comparing-the-skin-hydration-and-acceptability-of-two-emollient-products-in-atopic-eczema-patients-with-dry-skin
#11
Jasmina Djokic-Gallagher, Phil Rosher, Gabriela Oliveira, Jennine Walker
INTRODUCTION: Healthcare professionals tend to recommend emollients based primarily on patient/consumer preference and cost, with cheaper options assumed to be therapeutically equivalent. The aim of this study was therefore to compare the effects on skin hydration of two emollients prescribed in the UK, Doublebase Dayleve™ gel (DELP) and a cheaper alternative, Zerobase Emollient™ cream (ZBC). METHODS: This was a single-centre, randomised, double-blind, concurrent bi-lateral (within-patient) comparison in 18 females with atopic eczema and dry skin on their lower legs...
July 4, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28667496/skin-health-connected-to-the-use-of-absorbent-hygiene-products-a-review
#12
REVIEW
Johanna Karlsson Bender, Jan Faergemann, Maria Sköld
Over the past 50 years, absorbent hygiene products such as baby diapers and incontinence products have become essential features of modern day life. Through innovation and enhanced technology, their design, composition and performance have been dramatically upgraded from their early forms, and they have transformed the lives of millions of people, improving their quality of life. Skin health related to the use of absorbent hygiene products has accordingly also greatly improved. Still, the wearing of absorbent hygiene products will affect the skin, and for some users the changes in microclimate, mechanical interactions and the exposure to urine and faeces may result in irritant contact dermatitis, i...
June 30, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28677109/erratum-to-comparison-of-the-simple-patient-centric-atopic-dermatitis-scoring-system-pest-with-scorad-in-young-children-using-a-ceramide-dominant-therapeutic-moisturizer
#13
Mark Jean-Ann Koh, Yoke Chin Giam, Hui Min Liew, Alice Yee-Wah Foong, Jin Ho Chong, Sharon Mun Yee Wong, Mark Boon Yang Tang, Madeline Sheun Ling Ho, Lucinda Siyun Tan, James M Mason, Michael J Cork
No abstract text is available yet for this article.
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28639011/guselkumab-for-the-treatment-of-psoriasis-a-review-of-phase-iii-trials
#14
REVIEW
Mio Nakamura, Katherine Lee, Caleb Jeon, Sahil Sekhon, Ladan Afifi, Di Yan, Kristina Lee, Tina Bhutani
INTRODUCTION: Interleukin (IL)-23 inhibitors are a new class of biologics currently undergoing clinical trials for the treatment of moderate-to-severe psoriasis. Phase III studies of guselkumab, an IL-23 receptor monoclonal antibody, are currently underway. METHODS: We summarize the available phase III results to date, establishing the efficacy and safety of guselkumab in patients with moderate-to-severe plaque psoriasis. RESULTS: Currently, there are available data of up to 48 weeks from two Phase III, multicenter, randomized, double-blind, placebo- and comparator-controlled clinical trials, VOYAGE 1 and VOYAGE 2...
June 21, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28616853/comparison-of-the-simple-patient-centric-atopic-dermatitis-scoring-system-pest-with-scorad-in-young-children-using-a-ceramide-dominant-therapeutic-moisturizer
#15
Mark Jean-Ann Koh, Yoke Chin Giam, Hui Min Liew, Alice Yee-Wah Foong, Jin Ho Chong, Sharon Mun Yee Wong, Mark Boon Yang Tang, Madeline Sheun Ling Ho, Lucinda Siyun Tan, James M Mason, Michael J Cork
INTRODUCTION: Patient eczema severity time (PEST) is a new atopic dermatitis (AD) scoring system based on patients' own perception of their disease. Conventional scales such as SCORing of atopic dermatitis (SCORAD) reflect the clinician's observations during the clinic visit. Instead, the PEST score captures eczema severity, relapse and recovery as experienced by the patient or caregiver on a daily basis, promoting patient engagement, compliance with treatment and improved outcomes. This study aims to determine the correlation between carer-assessed PEST and clinician-assessed SCORAD in paediatric AD patients after 12 weeks of treatment using a ceramide-dominant therapeutic moisturizer...
June 14, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28600606/performance-and-tolerability-of-the-moisturizers-cetaphil-%C3%A2-and-excipial-%C3%A2-in-atopic-dermatitis-what-is-the-evidence-based-on-randomized-trials
#16
REVIEW
Esther J van Zuuren, Zbys Fedorowicz, Bernd W M Arents
INTRODUCTION: Moisturizers play a prominent role in the management of atopic dermatitis by improving the impaired skin barrier function and enhancing skin hydration. Their efficacy was evaluated in a recently published Cochrane Review 'Emollients and moisturizers for eczema'. OBJECTIVE: In the present review, we summarize the performance and safety of Cetaphil(®) and Excipial(®) moisturizing products. METHODS: This review was carried out in compliance with standard Cochrane methodological procedures, which means independent study selection, data extraction, assessment of risk of bias, and analyses by two review authors...
June 9, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28585191/why-topical-retinoids-are-mainstay-of-therapy-for-acne
#17
REVIEW
James Leyden, Linda Stein-Gold, Jonathan Weiss
Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guidelines for acne, including those from the American Academy of Dermatology (AAD) and the European Dermatology Forum (EDF), have agreed that retinoids have an essential role in this widespread disease...
June 5, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28526915/dietary-behaviors-in-psoriasis-patient-reported-outcomes-from-a-u-s-national-survey
#18
Ladan Afifi, Melissa J Danesh, Kristina M Lee, Kevin Beroukhim, Benjamin Farahnik, Richard S Ahn, Di Yan, Rasnik K Singh, Mio Nakamura, John Koo, Wilson Liao
INTRODUCTION: Psoriasis patients demonstrate high interest in the role of diet on their skin condition. However, data are lacking to describe dietary interventions among psoriasis patients and associated outcomes. This study aims to identify common dietary habits, interventions and perceptions among patients with psoriasis, and to examine patient-reported skin outcomes in response to these interventions. METHODS: We administered a 61-question survey to the National Psoriasis Foundation membership asking psoriasis patients about dietary habits, modifications, skin responses, and perceptions...
June 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28503712/dupilumab-improves-general-health-related-quality-of-life-in-patients-with-moderate-to-severe-atopic-dermatitis-pooled-results-from-two-randomized-controlled-phase-3-clinical-trials
#19
Eric L Simpson
INTRODUCTION: Patients with moderate-to-severe atopic dermatitis (AD) report a multidimensional disease burden that includes impaired health-related quality-of-life (HRQoL). Changes in overall health status and specific dimensions that contribute to HRQoL were evaluated in adults with moderate-to-severe AD who participated in phase 3 clinical trials of dupilumab, which is a fully human monoclonal antibody that inhibits signaling of cytokines IL-4 and IL-13. METHODS: Two dupilumab phase 3 clinical trials of identical design included the 5-dimension 3-level EuroQol (EQ-5D) as a measure of HRQoL...
June 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28484898/virus-induced-cancers-of-the-skin-and-mucosa-are-we-dealing-with-smoking-guns-or-smoke-and-mirrors-in-the-operating-theatre
#20
Peter K C Goon, Patrick K Y Goon, Eunice K H Tan, Robin A F Crawford, Nick J Levell, Holger Sudhoff
INTRODUCTION: Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Merkel cell polyomavirus (MCV) is a more recently discovered virus which causes Merkel cell carcinoma, a rare but highly aggressive skin malignancy. METHODS: We explored the available published evidence to see if transmission of live HPV or MCV virus in smoke generated by laser or diathermy was feasible, and would pose an infection risk...
June 2017: Dermatology and Therapy
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