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Dermatology and Therapy

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https://www.readbyqxmd.com/read/29322431/daylight-photodynamic-therapy-versus-5-fluorouracil-for-the-treatment-of-actinic-keratosis-a-case-series
#1
Gaston Nestor Galimberti
INTRODUCTION: The incidence of actinic keratosis (AK) continues to increase worldwide. Currently available options for the treatment of AK include topical 5-fluorouracil (5-FU) and daylight-mediated photodynamic therapy (DL-PDT). This split-face pilot study compared DL-PDT using 16% methyl aminolevulinate (MAL) cream versus 5-FU cream in patients with AK on the face/scalp. METHODS: Five male subjects (mean age 70 years) with grade I-III AK on the face/scalp were enrolled...
January 10, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29282672/successful-treatment-of-refractory-vitiligo-with-a-combination-of-khellin-and-308-nm-excimer-lamp-an-open-label-1-year-prospective-study
#2
Samy Fenniche, Anissa Zaouak, Azima Ben Tanfous, Meriem Jrad, Houda Hammami
INTRODUCTION: Phototherapy is the cornerstone of treatment of vitiligo. The 308-nm excimer lamp (EL) induces T cell apoptosis and the stimulation of melanocyte proliferation. Khellin is a furanochromone with a chemical structure close to psoralens. The objective of the study was to evaluate the safety and efficacy of 1-year treatment of recalcitrant vitiligo with a combination of 308-nm EL and khellin. METHODS: Twenty patients with resistant vitiligo were included...
December 27, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29260428/parrot-beak-nails-revisited-case-series-and-comprehensive-review
#3
Stella X Chen, Philip R Cohen
The term "parrot beak nail" describes a morphologic change of the nail plate characterized by excessive forward curvature. It may be associated with systemic disease or, most commonly, occurs as an idiopathic finding complicated by delayed nail plate trimming. The characteristics of parrot beak nails in ten men are described, and the features of this acquired nail deformity are reviewed. Of the ten patients, six presented with concurrent neuropathies that resulted in frequent foot injuries or falls. While the true incidence of parrot beak nails is unknown, this nail deformity occurred in 2...
December 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29222624/dapsone-for-recalcitrant-eosinophilic-annular-erythema-a-case-report-and-literature-review
#4
Luke Wallis, Robert C Gilson, Robert T Gilson
Eosinophilic annular erythema (EAE) is a rare entity of unknown etiology that is possibly related to a hypersensitivity reaction and presents as annular erythematous plaques with tissue eosinophilia. It is classified as a figurate erythema with a controversial relationship to Wells syndrome (WS) in the literature, where it is generally considered a separate entity or subset based on clinical and histopathologic differences. EAE typically presents with recurrent, erythematous, arcuate, and annular plaques on the trunk and proximal extremities...
December 8, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29218492/efficacy-of-secukinumab-in-the-treatment-of-moderate-to-severe-plaque-psoriasis-in-the-north-american-subgroup-of-patients-pooled-analysis-of-four-phase-3-studies
#5
David Pariser, Ellen Frankel, Joel Schlessinger, Yves Poulin, Ronald Vender, Richard G Langley, Xiangyi Meng, Adriana Guana, Judit Nyirady
INTRODUCTION: Demographic and disease characteristics may impact response to psoriasis therapies. The objective of this study is to explore the safety and efficacy profile of secukinumab in North American (NA) versus non-NA patients with moderate to severe psoriasis. METHODS: Data were pooled from four phase 3 studies of secukinumab. Secukinumab (300 and 150 mg) was administered at baseline, weeks 1, 2, and 3, then every 4 weeks from week 4 to 48. RESULTS: Peak efficacy was observed at week 16 in NA and non-NA patients with secukinumab 300 mg and secukinumab 150 mg, and disease clearance was maintained to week 52...
December 7, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29214505/efficacy-and-safety-of-three-cryotherapy-devices-for-wart-treatment-a-randomized-controlled-investigator-blinded-comparative-study
#6
Imko Walczuk, Frank Eertmans, Bart Rossel, Agnieszka Cegielska, Eggert Stockfleth, Andre Antunes, Els Adriaens
INTRODUCTION: Cutaneous warts are common skin lesions, caused by human papillomavirus. For years, liquid nitrogen is the cryogen of choice for wart treatment. Alternatively, several cryogenic devices for home treatment are commercially available. The present trial assessed efficacy and safety of a novel nitrous oxide-based cryogenic device for home use (EndWarts Freeze® in Europe, Compound W® Nitro-Freeze in the USA). METHODS: This investigator-blinded, controlled, randomized study compared the nitrous oxide device (test product) with a dimethylether propane-based product (Wartner®; comparator 1)...
December 6, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29204894/the-development-of-the-genital-psoriasis-sexual-frequency-questionnaire-genps-sfq-to-assess-the-impact-of-genital-psoriasis-on-sexual-health
#7
Alice B Gottlieb, Brian Kirby, Caitriona Ryan, April N Naegeli, Russel Burge, Alison Potts Bleakman, Milena D Anatchkova, Jennifer Cather
INTRODUCTION: Patient-reported outcome measures (PROs) exist for psoriasis but not genital psoriasis (GenPs). METHODS: This cross-sectional, qualitative study in patients with moderate-to-severe GenPs was conducted to support development of a PRO for measuring the impact of GenPs on sexual activity and to establish content validity. The impacts of GenPs were identified in a literature review. Findings from the literature review were discussed with clinicians, and then patients with GenPs were interviewed...
December 4, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29204893/the-development-of-a-patient-reported-outcome-measure-for-assessment-of-genital-psoriasis-symptoms-the-genital-psoriasis-symptoms-scale-gpss
#8
Alice B Gottlieb, Brian Kirby, Caitriona Ryan, April N Naegeli, Russel Burge, Alison Potts Bleakman, Milena D Anatchkova, Gil Yosipovitch
INTRODUCTION: Patient-reported outcome measures (PROs) specific for genital psoriasis (GenPs) have not been described. METHODS: In this cross-sectional, qualitative study in patients with moderate-to-severe GenPs, we sought to develop a PRO useful for GenPs symptom assessment. A literature review was performed to identify relevant psoriasis or GenPs symptoms and existing PROs that may be useful in the evaluation of symptom severity in GenPs patients. The literature review findings were discussed with clinicians, and then patients with GenPs...
December 4, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29196889/durable-resolution-of-severe-psoriasis-in-a-patient-treated-with-pentostatin-for-hairy-cell-leukemia-a-case-report
#9
Tamim Alsuliman, Kaiss Lassoued, Maifa Belghoul, Karima Debbache, Bachra Choufi
INTRODUCTION: Pentostatin (2'-deoxycoformycin) and cladribine (2-chlorodeoxyadenosine) are adenosine analogues widely used to treat lymphoid malignancies, mainly hairy cell leukemia (HCL). Oral or parenteral adenosine analogues have been also used as immunomodulatory agents in multiple sclerosis and in acute graft-versus-host disease. CASE REPORT: Here, we report the case of a 43-year-old patient with a history of extensive psoriasis who later developed HCL. RESULTS: The patient had achieved complete remission of both psoriasis and HCL after receiving intravenous infusions of pentostatin...
December 1, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29177802/correction-to-certolizumab-pegol-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-preliminary-real-life-data
#10
Annunziata Dattola, Maria Vittoria Cannizzaro, Mauro Mazzeo, Luca Bianchi
In the original publication, part Fig. 3b and c were interchanged. The correct versions are given below.
November 25, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29143230/the-efficacy-of-biologic-therapy-for-the-management-of-palmoplantar-psoriasis-and-palmoplantar-pustulosis-a-systematic-review
#11
REVIEW
Isabelle M Sanchez, Eric Sorenson, Ethan Levin, Wilson Liao
INTRODUCTION: Palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) are diseases affecting the hands and/or feet that can cause marked physical discomfort and functional disability. The tumor necrosis factor-alpha antagonists adalimumab, etanercept, and infliximab, the interleukin (IL)-17A inhibitors ixekizumab and secukinumab, and the IL-23 or IL-12/IL-23 inhibitors guselkumab and ustekinumab have been well studied for the treatment of moderate to severe plaque psoriasis. Less is known about the efficacy and safety of these agents for the treatment of PP (hyperkeratotic and pustular forms) and PPP...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29139035/certolizumab-pegol-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-preliminary-real-life-data
#12
Annunziata Dattola, Maria Vittoria Cannizzaro, Mauro Mazzeo, Luca Bianchi
INTRODUCTION: We present the results of real-life tests conducted in adults affected by psoriatic arthritis (PsA) with mild cutaneous involvement to evaluate the efficacy of certolizumab pegol (CZP), an anti-tumor necrosis factor-alpha agent approved in Europe for the treatment of rheumatoid arthritis and PsA. METHODS: Assessments included an evaluation of the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score computed on 44 joints (DAS-44) correlated to the erythrocyte sedimentation rate (ESR) (DAS44-ESR)...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29134613/dfd-01-reduces-transepidermal-water-loss-and-improves-skin-hydration-and-flexibility
#13
J Mark Jackson, Gary L Grove, Kent Allenby, Tim Houser
INTRODUCTION: In plaque psoriasis, the benefit of topical steroids is well established. The vehicle formulation of topical steroids may also provide benefit in addition to the effects of the steroid itself. DFD-01 (betamethasone dipropionate spray, 0.05%) is a formulation composed of a topical steroid in an emollient-like vehicle that enhances penetration to the target site of inflammation in the skin. The aim of this study was to assess the effect of DFD-01 and its vehicle on skin hydration and barrier function in compromised skin and to evaluate its effect on flexibility in healthy skin...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29076000/patients-perspectives-on-the-impact-of-genital-psoriasis-a-qualitative-study
#14
Jennifer Clay Cather, Caitriona Ryan, Kim Meeuwis, Alison J Potts Bleakman, April N Naegeli, Emily Edson-Heredia, Jiat Ling Poon, Cate Jones, Ashley N Wallace, Lyn Guenther, Scott Fretzin
INTRODUCTION: Plaque psoriasis is a chronic skin disease where genital involvement is relatively common. Yet health care providers do not routinely evaluate psoriasis patients for genital involvement and patients do not readily initiate discussion of it. METHODS: A qualitative study of 20 US patients with dermatologist-confirmed genital psoriasis (GenPs) and self-reported moderate-to-severe GenPs at screening was conducted to identify key GenPs symptoms and their impacts on health-related quality of life (HRQoL)...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29052800/dermatologist-and-patient-preferences-in-choosing-treatments-for-moderate-to-severe-psoriasis
#15
Matthew Alcusky, Seina Lee, Gordon Lau, Gretchen R Chiu, Nandini Hadker, Aparna Deshpande, Stephen Fleming, Nicola Vance, Steve Fakharzadeh
INTRODUCTION: The objective of the study was to determine the relative importance (RI) of treatment attributes psoriasis patients and physicians consider when choosing between biologic therapies based on psoriasis severity. METHODS: A discrete choice experiment (DCE) weighting preference for eight sets of hypothetical treatments for moderate or severe psoriasis was conducted. DCE hypothetical treatments were defined and varied on combinations of efficacy, safety, and dosing attributes [frequency/setting/route of administration (ROA)]...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29052100/acute-localized-exanthematous-pustulosis-alep-review-of-literature-with-report-of-case-caused-by-amoxicillin-clavulanic-acid
#16
Alessia Villani, Antonello Baldo, Gaia De Fata Salvatores, Vincenzo Desiato, Fabio Ayala, Carlo Donadio
Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and many other medications has also been reported. Skin reaction arises quickly within a few hours, resolving rapidly within a few days without treatment, and it is usually accompanied by fever and neutrophilic leukocytosis...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29027127/use-of-supplementary-patient-education-material-increases-treatment-adherence-and-satisfaction-among-acne-patients-receiving-adapalene-0-1-benzoyl-peroxide-2-5-gel-in-primary-care-clinics-a-multicenter-randomized-controlled-clinical-study
#17
Timothy Myhill, Warwick Coulson, Paul Nixon, Simon Royal, Terry McCormack, Nabil Kerrouche
INTRODUCTION: Poor adherence to acne treatment may lead to unnecessary treatments, increased healthcare costs, and reduced quality of life (QoL). This multicenter study evaluated the effect of supplementary patient education material (SEM) (a short video, information card, and additional information available online) on treatment adherence and satisfaction among acne patients treated with the fixed-dose combination adapalene 0.1%/benzoyl peroxide 2.5% gel (A/BPO) in primary care clinics versus (1) standard-of-care patient education (SOCPE) (package insert and oral instruction) and (2) SOCPE plus more frequent clinic visits...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29022273/staphylococcus-lugdunensis-infections-of-the-skin-and-soft-tissue-a-case-series-and-review
#18
Lucas A Heldt Manica, Philip R Cohen
INTRODUCTION: Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative, Gram-positive bacterium that can be isolated as a component of normal skin flora in humans. However, more recently, it has also been documented as a culprit in skin and soft tissue infections. We describe the clinical features of five individuals with S. lugdunensis-associated skin infections. We review the characteristics of other patients that were previously described with this organism as the causative agent of skin infection...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28933010/economic-evaluation-of-dupilumab-for-the-treatment-of-moderate-to-severe-atopic-dermatitis-in-adults
#19
Andreas Kuznik, Gaëlle Bégo-Le-Bagousse, Laurent Eckert, Abhijit Gadkari, Eric Simpson, Christopher N Graham, LaStella Miles, Vera Mastey, Puneet Mahajan, Sean D Sullivan
INTRODUCTION: Dupilumab significantly improves signs and symptoms of atopic dermatitis (AD), including pruritus, symptoms of anxiety and depression, and health-related quality of life versus placebo in adults with moderate-to-severe AD. Since the cost-effectiveness of dupilumab has not been evaluated, the objective of this analysis was to estimate a value-based price range in which dupilumab would be considered cost-effective compared with supportive care (SC) for treatment of moderate-to-severe AD in an adult population...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28905294/high-patient-satisfaction-with-daylight-activated-methyl-aminolevulinate-cream-in-the-treatment-of-multiple-actinic-keratoses-results-of-an-observational-study-in-australia
#20
Jo-Ann See, Kurt Gebauer, Jason K Wu, Shobhan Manoharan, Nabil Kerrouche, John Sullivan
INTRODUCTION: Actinic keratoses (AK) are treated to reduce the risk of progression to squamous cell carcinoma and for symptomatic and cosmetic benefits. The objective of this observational study was to generate real-life data on the use of daylight photodynamic therapy with methyl aminolevulinate cream (MAL DL-PDT) in treating mild to moderate facial/scalp AK. METHODS: A multicenter, prospective, observational study was conducted in Australia in patients receiving a single treatment of MAL DL-PDT for mild to moderate AK...
December 2017: Dermatology and Therapy
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