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Dermatology and Therapy

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https://www.readbyqxmd.com/read/29143230/the-efficacy-of-biologic-therapy-for-the-management-of-palmoplantar-psoriasis-and-palmoplantar-pustulosis-a-systematic-review
#1
REVIEW
Isabelle M Sanchez, Eric Sorenson, Ethan Levin, Wilson Liao
INTRODUCTION: Palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) are diseases affecting the hands and/or feet that can cause marked physical discomfort and functional disability. The tumor necrosis factor-alpha antagonists adalimumab, etanercept, and infliximab, the interleukin (IL)-17A inhibitors ixekizumab and secukinumab, and the IL-23 or IL-12/IL-23 inhibitors guselkumab and ustekinumab have been well studied for the treatment of moderate to severe plaque psoriasis. Less is known about the efficacy and safety of these agents for the treatment of PP (hyperkeratotic and pustular forms) and PPP...
November 15, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29139035/certolizumab-pegol-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-preliminary-real-life-data
#2
Annunziata Dattola, Maria Vittoria Cannizzaro, Mauro Mazzeo, Luca Bianchi
INTRODUCTION: We present the results of real-life tests conducted in adults affected by psoriatic arthritis (PsA) with mild cutaneous involvement to evaluate the efficacy of certolizumab pegol (CZP), an anti-tumor necrosis factor-alpha agent approved in Europe for the treatment of rheumatoid arthritis and PsA. METHODS: Assessments included an evaluation of the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score computed on 44 joints (DAS-44) correlated to the erythrocyte sedimentation rate (ESR) (DAS44-ESR)...
November 14, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29134613/dfd-01-reduces-transepidermal-water-loss-and-improves-skin-hydration-and-flexibility
#3
J Mark Jackson, Gary L Grove, Kent Allenby, Tim Houser
INTRODUCTION: In plaque psoriasis, the benefit of topical steroids is well established. The vehicle formulation of topical steroids may also provide benefit in addition to the effects of the steroid itself. DFD-01 (betamethasone dipropionate spray, 0.05%) is a formulation composed of a topical steroid in an emollient-like vehicle that enhances penetration to the target site of inflammation in the skin. The aim of this study was to assess the effect of DFD-01 and its vehicle on skin hydration and barrier function in compromised skin and to evaluate its effect on flexibility in healthy skin...
November 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29076000/patients-perspectives-on-the-impact-of-genital-psoriasis-a-qualitative-study
#4
Jennifer Clay Cather, Caitriona Ryan, Kim Meeuwis, Alison J Potts Bleakman, April N Naegeli, Emily Edson-Heredia, Jiat Ling Poon, Cate Jones, Ashley N Wallace, Lyn Guenther, Scott Fretzin
INTRODUCTION: Plaque psoriasis is a chronic skin disease where genital involvement is relatively common. Yet health care providers do not routinely evaluate psoriasis patients for genital involvement and patients do not readily initiate discussion of it. METHODS: A qualitative study of 20 US patients with dermatologist-confirmed genital psoriasis (GenPs) and self-reported moderate-to-severe GenPs at screening was conducted to identify key GenPs symptoms and their impacts on health-related quality of life (HRQoL)...
October 26, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29052800/dermatologist-and-patient-preferences-in-choosing-treatments-for-moderate-to-severe-psoriasis
#5
Matthew Alcusky, Seina Lee, Gordon Lau, Gretchen R Chiu, Nandini Hadker, Aparna Deshpande, Stephen Fleming, Nicola Vance, Steve Fakharzadeh
INTRODUCTION: The objective of the study was to determine the relative importance (RI) of treatment attributes psoriasis patients and physicians consider when choosing between biologic therapies based on psoriasis severity. METHODS: A discrete choice experiment (DCE) weighting preference for eight sets of hypothetical treatments for moderate or severe psoriasis was conducted. DCE hypothetical treatments were defined and varied on combinations of efficacy, safety, and dosing attributes [frequency/setting/route of administration (ROA)]...
October 20, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29052100/acute-localized-exanthematous-pustulosis-alep-review-of-literature-with-report-of-case-caused-by-amoxicillin-clavulanic-acid
#6
Alessia Villani, Antonello Baldo, Gaia De Fata Salvatores, Vincenzo Desiato, Fabio Ayala, Carlo Donadio
Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and many other medications has also been reported. Skin reaction arises quickly within a few hours, resolving rapidly within a few days without treatment, and it is usually accompanied by fever and neutrophilic leukocytosis...
October 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29027127/use-of-supplementary-patient-education-material-increases-treatment-adherence-and-satisfaction-among-acne-patients-receiving-adapalene-0-1-benzoyl-peroxide-2-5-gel-in-primary-care-clinics-a-multicenter-randomized-controlled-clinical-study
#7
Timothy Myhill, Warwick Coulson, Paul Nixon, Simon Royal, Terry McCormack, Nabil Kerrouche
INTRODUCTION: Poor adherence to acne treatment may lead to unnecessary treatments, increased healthcare costs, and reduced quality of life (QoL). This multicenter study evaluated the effect of supplementary patient education material (SEM) (a short video, information card, and additional information available online) on treatment adherence and satisfaction among acne patients treated with the fixed-dose combination adapalene 0.1%/benzoyl peroxide 2.5% gel (A/BPO) in primary care clinics versus (1) standard-of-care patient education (SOCPE) (package insert and oral instruction) and (2) SOCPE plus more frequent clinic visits...
October 12, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29022273/staphylococcus-lugdunensis-infections-of-the-skin-and-soft-tissue-a-case-series-and-review
#8
Lucas A Heldt Manica, Philip R Cohen
INTRODUCTION: Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative, Gram-positive bacterium that can be isolated as a component of normal skin flora in humans. However, more recently, it has also been documented as a culprit in skin and soft tissue infections. We describe the clinical features of five individuals with S. lugdunensis-associated skin infections. We review the characteristics of other patients that were previously described with this organism as the causative agent of skin infection...
October 11, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28933010/economic-evaluation-of-dupilumab-for-the-treatment-of-moderate-to-severe-atopic-dermatitis-in-adults
#9
Andreas Kuznik, Gaëlle Bégo-Le-Bagousse, Laurent Eckert, Abhijit Gadkari, Eric Simpson, Christopher N Graham, LaStella Miles, Vera Mastey, Puneet Mahajan, Sean D Sullivan
INTRODUCTION: Dupilumab significantly improves signs and symptoms of atopic dermatitis (AD), including pruritus, symptoms of anxiety and depression, and health-related quality of life versus placebo in adults with moderate-to-severe AD. Since the cost-effectiveness of dupilumab has not been evaluated, the objective of this analysis was to estimate a value-based price range in which dupilumab would be considered cost-effective compared with supportive care (SC) for treatment of moderate-to-severe AD in an adult population...
September 20, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28905294/high-patient-satisfaction-with-daylight-activated-methyl-aminolevulinate-cream-in-the-treatment-of-multiple-actinic-keratoses-results-of-an-observational-study-in-australia
#10
Jo-Ann See, Kurt Gebauer, Jason K Wu, Shobhan Manoharan, Nabil Kerrouche, John Sullivan
INTRODUCTION: Actinic keratoses (AK) are treated to reduce the risk of progression to squamous cell carcinoma and for symptomatic and cosmetic benefits. The objective of this observational study was to generate real-life data on the use of daylight photodynamic therapy with methyl aminolevulinate cream (MAL DL-PDT) in treating mild to moderate facial/scalp AK. METHODS: A multicenter, prospective, observational study was conducted in Australia in patients receiving a single treatment of MAL DL-PDT for mild to moderate AK...
September 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28853054/erratum-to-the-burden-of-chronic-urticaria-from-brazilian-patients-perspective
#11
Maria-Magdalena Balp, Nilcéia Lopes da Silva, Jeffrey Vietri, Haijun Tian, Luis F Ensina
No abstract text is available yet for this article.
August 29, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28836173/hpv-47-induced-and-tattoo-associated-verrucae-planae-report-of-a-case-and-review-of-the-literature
#12
Nathalie Krecké, Sigrun Smola, Thomas Vogt, Cornelia Sigrid Lissi Müller
The human papillomavirus (HPV), of which more than 200 different types have so far been identified, is an infectious disease impacting skin and mucous membranes. Several genera exist with distinct clinical impact. However, with ornamental tattoos increasing in popularity, a number of mostly cutaneous side effects have also been reported, such as infections, allergic reactions, or even a rise of malignant tumours within the tattoo. We report the first case of a β1-HPV-type infection in cutaneous lesions in terms of verrucae vulgares near a tattoo in an immunocompetent adult without pre-existing conditions, and discuss possible relationships and etiologic concerns of this association...
August 23, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28815476/long-term-safety-and-effectiveness-of-adalimumab-for-moderate-to-severe-psoriasis-results-from-7-year-interim-analysis-of-the-esprit-registry
#13
Alan Menter, Diamant Thaçi, Jashin J Wu, William Abramovits, Francisco Kerdel, Dilek Arikan, Dianlin Guo, Arijit Ganguli, Mareike Bereswill, Anne Camez, Wendell C Valdecantos
INTRODUCTION: ESPRIT (NCT00799877) is an ongoing 10-year international prospective observational registry evaluating the long-term safety and effectiveness of originator adalimumab in routine clinical practice for adult patients with chronic plaque psoriasis. Herein, we report the long-term safety, effectiveness, and patient-reported outcomes (PROs) following adalimumab treatment over the first 7 years of the ESPRIT registry. METHODS: All treatment-emergent (All-TE) adverse events (AE) since the initial (first ever) dose of adalimumab were assessed...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28785924/optimizing-anti-inflammatory-and-immunomodulatory-effects-of-corticosteroid-and-vitamin-d-analogue-fixed-dose-combination-therapy
#14
REVIEW
Siegfried Segaert, Neil H Shear, Andrea Chiricozzi, Diamant Thaçi, Jose-Manuel Carrascosa, Helen Young, Vincent Descamps
Fixed-dose combination topical therapy with corticosteroid and vitamin D analog provides effective treatment and possible long-term management of psoriasis. The anti-inflammatory and immunomodulatory effects of corticosteroids and vitamin D analogs in treating psoriasis are well investigated; their complementary effects lead to the disruption of the inflammatory feedback loop underlying psoriasis pathogenesis. Recent preclinical data showed that combination therapy is more effective than monotherapies of the active ingredients in preventing activation of resting pro-inflammatory cells, inducing immunomodulation, reducing inflammatory responses by regulating T cell production, and normalizing keratinocytes...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28748406/therapeutic-effects-of-topical-tranexamic-acid-in-comparison-with-hydroquinone-in-treatment-of-women-with-melasma
#15
Najmolsadat Atefi, Behzad Dalvand, Mahammadreza Ghassemi, Golnaz Mehran, Amir Heydarian
INTRODUCTION: Few studies have focused on therapeutic as well as side effects of tranexamic acid (TXA) as a topical drug compared to other topical drugs in treating melasma. The present study aimed to assess and compare the beneficial therapeutic effects and also side effects of local TXA in comparison with hydroquinone in treating women with melasma. METHODS: This randomized double-blinded clinical trial was performed on 60 women who suffered from melasma and were referred to the skin disorders clinic at the Rasoul-e-Akram hospital in Tehran in 2015...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28726212/melasma-an-up-to-date-comprehensive-review
#16
REVIEW
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28710659/comparison-of-the-effect-of-skin-preparation-pads-on-transepidermal-water-loss-in-ex-vivo-human-skin
#17
Hanan Osman-Ponchet, Alexandre Gaborit, Magali Kouidhi, Sandrine Anglars, Jeanne Marceau-Suissa, Orla Duffy-Roger, Jean-Michel Linget, Claire E Wilson
INTRODUCTION: Pre-treatment of the skin to remove scales and crusts prior to photodynamic therapy (PDT) is essential to enhance the uptake of topically applied methyl aminolevulinate (MAL) and to improve treatment efficacy. This study compared the effect of two different skin preparation pads on skin integrity in ex vivo human skin. METHODS: Ex vivo human skin samples from three donors were pre-treated in triplicates with PREPSTER™ (PR) skin preparation pad (6, 8, and 10 passages) or Ambu Unilect™ (A-UN) skin preparation pad (6, 8, and 10 passages)...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28707054/frequency-and-management-of-sleep-disturbance-in-adults-with-atopic-dermatitis-a-systematic-review
#18
REVIEW
Caleb Jeon, Di Yan, Mio Nakamura, Sahil Sekhon, Tina Bhutani, Timothy Berger, Wilson Liao
INTRODUCTION: Intense nocturnal pruritus as well as the complex pathophysiology of atopic dermatitis (AD) can severely affect sleep and become a major factor in negatively impacting quality of life in adults. However, much of the literature on sleep disturbance in AD patients is on the pediatric population, and it is not well studied in adults. Furthermore, limited studies are available to guide effective management of sleep disturbance in AD in general. We review the literature to present the studies that have investigated the relationship between AD and its effect on sleep in adults and provide an approach for clinicians caring for this population...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28677110/a-double-blind-randomised-study-comparing-the-skin-hydration-and-acceptability-of-two-emollient-products-in-atopic-eczema-patients-with-dry-skin
#19
Jasmina Djokic-Gallagher, Phil Rosher, Gabriela Oliveira, Jennine Walker
INTRODUCTION: Healthcare professionals tend to recommend emollients based primarily on patient/consumer preference and cost, with cheaper options assumed to be therapeutically equivalent. The aim of this study was therefore to compare the effects on skin hydration of two emollients prescribed in the UK, Doublebase Dayleve™ gel (DELP) and a cheaper alternative, Zerobase Emollient™ cream (ZBC). METHODS: This was a single-centre, randomised, double-blind, concurrent bi-lateral (within-patient) comparison in 18 females with atopic eczema and dry skin on their lower legs...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28677109/erratum-to-comparison-of-the-simple-patient-centric-atopic-dermatitis-scoring-system-pest-with-scorad-in-young-children-using-a-ceramide-dominant-therapeutic-moisturizer
#20
Mark Jean-Ann Koh, Yoke Chin Giam, Hui Min Liew, Alice Yee-Wah Foong, Jin Ho Chong, Sharon Mun Yee Wong, Mark Boon Yang Tang, Madeline Sheun Ling Ho, Lucinda Siyun Tan, James M Mason, Michael J Cork
No abstract text is available yet for this article.
September 2017: Dermatology and Therapy
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