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Dermatology and Therapy

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https://www.readbyqxmd.com/read/30006866/effect-of-prior-biologic-use-on-cost-effectiveness-of-brodalumab-vs-ustekinumab-for-treatment-of-moderate-to-severe-psoriasis-in-the-united-states
#1
Steven R Feldman, Shipra Rastogi, Jay Lin
INTRODUCTION: Clinical trials have shown brodalumab to have better efficacy than ustekinumab for the treatment of moderate-to-severe psoriasis. An estimation of the cost-effectiveness of brodalumab vs. ustekinumab is warranted and may be useful for treatment decision-making processes, especially in the context of the cost considerations of the current US healthcare system. Therefore, we compared the cost-effectiveness of brodalumab with ustekinumab for treatment of moderate-to-severe psoriasis in biologic-naïve and biologic-experienced patients in the USA...
July 13, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29987683/patient-reported-improvement-after-patch-testing-and-allergen-avoidance-counseling-a-retrospective-analysis
#2
Meredith S Steuer, Nina C Botto
INTRODUCTION: Our objectives were to assess patient-reported improvement after patch testing at the 2-3-month follow-up visit in patients referred for patch testing with relevant positive patch test reactions at the University of California, San Francisco. METHODS: Cross-sectional analyses of patients patch tested between 2013 and 2016 who returned for a follow-up visit approximately 2-3 months after patch testing. We examined positive patch test results considered of definite, probable or possible relevance to the patient's eczematous eruptions...
July 9, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29943217/topical-ivermectin-in-the-treatment-of-papulopustular-rosacea-a-systematic-review-of-evidence-and-clinical-guideline-recommendations
#3
REVIEW
Chiel Cristiano F Ebbelaar, Aalt W Venema, Maria R Van Dijk
INTRODUCTION: Rosacea is a chronic inflammatory skin disease with different phenotypes. There is accumulating evidence that the commensal Demodex mite is linked to papulopustular rosacea. Established treatment options, including topical metronidazole, azelaic acid, and tetracyclines, are thought to work through their anti-inflammatory effects. However, none of these therapies have been shown to be curative and are associated with frequent relapses. Therefore, new and improved treatment options are needed...
June 25, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29916197/efficacy-endpoints-in-clinical-trials-in-actinic-keratosis
#4
Torsten Skov, Eggert Stockfleth, Rolf-Markus Szeimies, Brian Berman
INTRODUCTION: Actinic keratosis is regarded as a chronic disease of the skin and, although fluctuating, is chronically progressive. Approval of new products for the treatment of actinic keratosis requires the use of a standard methodology in clinical trials which emphasize complete clearance of all actinic keratoses in a treatment field in a defined time span and the evaluation of long-term efficacy in terms of recurrence rate among completely cleared patients. METHODS: Analysis of data from six previously published clinical trials in patients with actinic keratosis...
June 18, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29905913/development-of-low-cost-locally-sourced-two-component-compression-bandages-in-western-kenya
#5
Aileen Y Chang, Edith C Tonui, Douglas Momanyi, Alex R Mills, Paul Wasike, Rakhi Karwa, Toby A Maurer, Sonak D Pastakia
INTRODUCTION: Compression therapy is well-established standard of care for chronic leg ulcers from venous disease and lymphedema. Chronic leg ulcers and lymphedema have a significant impact on quality of life, driven by pain, foul odor, and restricted mobility. Provision of layered compression therapy in resource-limited settings, as in Western Kenya and other regions of sub-Saharan Africa, is a major challenge due to several barriers: availability, affordability, and access to healthcare facilities...
June 15, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29876724/building-a-citizen-pscientist-advancing-patient-centered-psoriasis-research-by-empowering-patients-as-contributors-and-analysts
#6
Isabelle M Sanchez, Lindsey Shankle, Marilyn T Wan, Ladan Afifi, Jashin J Wu, Frank Doris, Alisha Bridges, Marc Boas, Brian Lafoy, Sarah Truman, Ana-Maria Orbai, Junko Takeshita, Joel M Gelfand, April W Armstrong, Michael P Siegel, Wilson Liao
INTRODUCTION: To design and implement a novel cloud-based digital platform that allows psoriatic patients and researchers to engage in the research process. METHODS: Citizen Pscientist (CP) was created by the National Psoriasis Foundation (NPF) to support and educate the global psoriatic disease community, where patients and researchers have the ability to analyze data. Psoriatic patients were invited to enroll in CP and contribute health data to a cloud database by responding to a 59-question online survey...
June 6, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29860652/basal-cell-carcinoma-a-patient-and-physician-s-experience
#7
Barbara J Cohen, Eliahou S Cohen, Philip R Cohen
In this article, the first coauthor, a patient with a basal cell carcinoma on her upper lip, discusses her experience with Mohs micrographic surgery for the treatment of the skin cancer. The second coauthor, who is the patient's physician (a dermatologist who shares her last name but is not a relative), diagnosed her skin cancer and referred her for Mohs surgery. The third coauthor, who is the patient's son and not only a dermatologist, but also a dermatopathologist and a Mohs surgeon (and also shares her last name), summarizes the presentation and treatment of the basal cell carcinoma...
June 2, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29858763/a-systematic-scoping-literature-review-of-publications-supporting-treatment-guidelines-for-pediatric-atopic-dermatitis-in-contrast-to-clinical-practice-patterns
#8
REVIEW
Elaine C Siegfried, Jennifer C Jaworski, Paola Mina-Osorio
INTRODUCTION: Treatment guidelines endorse a variety of strategies for atopic dermatitis (AD) which may vary from published data and clinical practice patterns. The objective of this review was to quantify the volume of available medical literature supporting pediatric AD treatments and compare these patterns to those recommended by published guidelines and/or clinical practice patterns. METHODS: Searches of Embase (2005-2016) and abstracts from selected meetings (2014-2016) related to AD treatment in patients younger than 17 years of age yielded references that were assessed by study design, primary treatment, age groups, and AD severity...
June 1, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29855896/treatment-of-grade-ii-and-iii-actinic-keratosis-lesions-with-a-film-forming-medical-device-containing-sunscreen-piroxicam-0-8-and-a-retinoic-acid-glycolic-gel-a-pilot-trial
#9
Mario Puviani, Massimo Milani
INTRODUCTION: Lesion and field-targeted treatments of actinic keratosis (AK) are commonly indicated for grade I and II type lesions. Grade III lesions are in general more difficult to treat. A film-forming medical device containing piroxicam 0.8% and sunscreen (SPF 50+) (PS) has been shown to be effective in the treatment of grade I and II AK lesions. Topical and oral retinoids have been utilized in AK and non-melanoma skin cancers. Topical glycolic acid promotes keratolysis and stimulates collagen synthesis for repair and skin rejuvenation and could be useful in AK treatment strategies...
May 31, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29855895/squamous-cell-carcinomas-in-two-cases-of-nail-lichen-planus-is-there-a-real-association
#10
Claudia Costa, Alessia Villani, Daniela Russo, Milena Cappello, Gaia De Fata Salvatores, Massimiliano Scalvenzi
Lichen planus (LP) is a chronic inflammatory disease that affects the skin and oral mucosa. Although its etiology is unknown, its potential for cancerization has been confirmed. We herein report the cases of a brother and sister, both with a 15-year history of nail lichen planus of the fingers and toes, who developed squamous cell carcinomas of the nail bed and matrix. This article shows the potential for malignant transformation in lichen planus disease and highlights the importance of periodic clinical follow-up...
May 31, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29790104/beneficial-effects-of-antioxidant-furfuryl-palmitate-in-non-pharmacologic-treatments-prescription-emollient-devices-peds-for-atopic-dermatitis-and-related-skin-disorders
#11
REVIEW
Paolo Daniele Pigatto, Marco Diani
INTRODUCTION: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. The aim of this review was to evaluate the efficacy and tolerability of furfuryl palmitate, a new antioxidant molecule, and furfuryl derivatives. METHODS: A PubMed/Google Scholar search was conducted using the term "furfuryl palmitate" (and its derivatives, including AR-GG27® ) combined with "skin," "atopic dermatitis," and "atopic eczema...
May 22, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29770909/omalizumab-in-chronic-spontaneous-urticaria-refractory-to-conventional-therapy-an-italian-retrospective-clinical-analysis-with-suggestions-for-long-term-maintenance-strategies
#12
Victor D Mandel, Mario B Guanti, Serena Liberati, Antongiulio Demonte, Giovanni Pellacani, Patrizia Pepe
INTRODUCTION: Omalizumab is indicated for the treatment of patients affected by chronic spontaneous urticaria (CSU) refractory to antihistamines. The aim of this study was to assess the efficacy, safety, and recurrence of symptoms in a real-life experience of omalizumab as an add-on therapy for H1 -antihistamine-refractory CSU patients (refractory CSU). METHODS: A retrospective review of the clinical records of all refractory CSU treated with omalizumab at our dermatology center from June 2014 to April 2017 was performed...
May 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29680914/the-potential-public-health-impact-of-herpes-zoster-vaccination-of-people-aged-%C3%A2-50-years-in-japan-results-of-a-markov-model-analysis
#13
Daisuke Watanabe, Akiko Mizukami, Katsiaryna Holl, Desmond Curran, Desirée Van Oorschot, Lijoy Varghese, Makoto Shiragami
INTRODUCTION: The aim of this study was to compare the public health impact of introducing two herpes zoster (HZ) vaccines into the vaccination programs for the Japanese population aged ≥ 50 years: a single-dose Varicella Vaccine Live (VVL) or a two-dose adjuvanted Recombinant Zoster Vaccine (RZV). METHODS: A multi-cohort static Markov model was developed to follow age cohorts (50-59, 60-69, 70-79 and ≥ 80 years) over their remaining lifetime. Japan-specific data inputs for the model were obtained from Japanese data sources...
April 21, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29777447/integra-%C3%A2-dermal-regeneration-template-and-split-thickness-skin-grafting-a-therapy-approach-to-correct-aplasia-cutis-congenita-and-epidermolysis-bullosa-in-carmi-syndrome
#14
Julian Trah, Christina Has, Ingrid Hausser, Heinz Kutzner, Konrad Reinshagen, Ingo Königs
The association of junctional epidermolysis bullosa with pyloric atresia (JEB-PA) and aplasia cutis congenita (ACC) was described by El Shafie et al. (J Pediatr Surg 14(4):446-449, 1979) and Carmi et al. (Am J Med Genet 11:319-328, 1982). Most patients die in the first weeks of life, and no curative treatment options are available so far. We describe a patient with JEB-PA and ACC (OMIM # 226730) who was treated for extensive areas of ACC by Integra® -Dermal Regeneration Template and split-thickness skin grafting (STSG)...
June 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29748843/exploration-of-patient-characteristics-and-quality-of-life-in-patients-with-lipoedema-using-a-survey
#15
Jeroen R M Romeijn, Michette J M de Rooij, Loes Janssen, Herm Martens
INTRODUCTION: Lipoedema is a chronic disorder in which excessive fat distribution occurs predominantly from the waist down, resulting in a disproportion between the lower extremities and upper torso. Lipoedema is often not recognized, while patients experience pain and easy bruising. As a long-term condition, lipoedema has a massive effect on patients' lives and mental health. The aim of this study is to explore patient characteristics, quality of life, physical complaints and comorbidities in patients with lipoedema...
June 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29728933/effect-of-topical-steroids-on-skin-prick-test-a-randomized-controlled-trial
#16
Anne R Ebbesen, Lene A Riis, Josefine Gradman
INTRODUCTION: Topically applied corticosteroids on the skin can significantly inhibit the wheal response to allergens in skin prick test (SPT). The duration of this effect is unknown. The aim of this study is to investigate the duration of the inhibitory effect of topical corticosteroids on SPT. METHODS: Twenty-two healthy subjects were included in a single-blinded randomized study. All subjects were skin prick tested using a standard inhalant allergen panel. The subjects were randomized to treat either the left or right forearm with Betnovat® cream (group III steroid) once a day for 10 days...
June 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29626322/a-scoping-review-protocol-to-explore-the-use-of-interleukin-1-targeting-drugs-for-the-treatment-of-dermatological-diseases-indications-mechanism-of-action-efficacy-and-safety
#17
REVIEW
Francisco Gómez-García, Juan Ruano, Jesús Gay-Mimbrera, Macarena Aguilar-Luque, Juan L Sanz-Cabanillas, José L Hernández Romero, Antonio Velez Garcia-Nieto
INTRODUCTION: The interleukin (IL)-1 pathway has been identified as being involved in inflammatory and neoplastic skin diseases such as psoriasis, atopic dermatitis, neutrophilic dermatosis, melanoma, and squamous cell carcinoma. Drugs developed to target the IL-1 pathway are currently used to treat these pathologies, and although they are becoming more selective, they are not exempt from adverse events and high costs. Integrating the best research evidence with clinical experience and patient needs has been shown to improve care, health, and cost outcomes...
April 6, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29574572/drug-treatment-for-androgenetic-alopecia-first-italian-questionnaire-survey-on-what-dermatologists-think-about-finasteride
#18
Elisabetta Sorbellini, Daniela Pinto, Barbara Marzani, Fabio Rinaldi
INTRODUCTION: Treatment with finasteride 1 mg/day represents the therapy of choice for androgenetic alopecia (AGA). We investigated how Italian dermatologists approach use of finasteride for treatment of AGA and common side effects reported by patients. METHODS: A tablet-based survey was conducted from February 2017 to January 2018 in Italy to investigating use of 1 mg/day finasteride in the treatment of AGA. Approximately 1153 Italian dermatologists were surveyed about prescription frequency, therapy duration, treatment practices, and side effects eventually reported...
March 24, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29551008/author-correction-secukinumab-demonstrates-significantly-lower-immunogenicity-potential-compared-to-ixekizumab
#19
Sebastian Spindeldreher, Bernard Maillère, Evelyne Correia, Maxime Tenon, Anette Karle, Philip Jarvis, Frank Kolbinger
In the original publication, information regarding "ustekinumab" was incorrectly published under the Methods section. The correct information in the section "Antibodies and Control Protein" should be "(secukinumab, 150 mg/mL; ixekizumab, 90 mg/mL; adalimumab, 50 mg/mL; ustekinumab 90 mg/ml)". Infliximab, which is mentioned in that section, was not used in the study.
March 17, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29549598/adapalene-0-3-gel-shows-efficacy-for-the-treatment-of-atrophic-acne-scars
#20
Manisha J Loss, Sherry Leung, Anna Chien, Nabil Kerrouche, Alexander H Fischer, Sewon Kang
INTRODUCTION: Scarring is an unfortunate clinical outcome of acne. Current treatment options for atrophic acne scars are dominated by non-pharmacological, invasive procedures which may not be suitable or affordable to all patients. This phase II, single-center, open-label, exploratory study assessed the efficacy, safety and subject-reported outcomes of adapalene 0.3% gel in the treatment of atrophic acne scars. METHODS: The study included subjects aged 18-50 years with past history of acne and moderate to severe facial atrophic acne scars...
March 16, 2018: Dermatology and Therapy
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