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Dermatology and Therapy

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https://www.readbyqxmd.com/read/28260214/polydactylous-transverse-erythronychia-report-of-a-patient-with-multiple-horizontal-red-bands-affecting-the-fingernails
#1
Carina Chang, Bryce D Beutler, Philip R Cohen
INTRODUCTION: Redness of the nail plate-erythronychia-is a common condition involving one or multiple digits. It may affect the entire nail or present as longitudinal red bands that extend from the proximal nail fold to the distal tip of the nail plate. Rarely, red bands may traverse the nail bed horizontally. Although erythronychia is often idiopathic, it has also been associated with amyloidosis, Darier's disease, lichen planus, and various other cutaneous conditions. We describe the clinical features of a 64-year-old Caucasian man who presented with transverse and longitudinal erythronychia affecting his fingernails...
March 4, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28258554/imaging-blood-vessel-morphology-in-skin-dynamic-optical-coherence-tomography-as-a-novel-potential-diagnostic-tool-in-dermatology
#2
REVIEW
Sandra Schuh, Jon Holmes, Martina Ulrich, Lotte Themstrup, Gregor B E Jemec, Nathalie De Carvalho, Giovanni Pellacani, Julia Welzel
Conventional optical coherence tomography (OCT) enables the visualization of morphological changes of skin cancer. The use of OCT in the diagnostic investigation and in the therapy decision of non-melanoma skin cancer and other skin changes is already established, and has found its way into routine practice. With the development of speckle-variance OCT, also named dynamic OCT (D-OCT), the vascular architecture and the blood flow of the skin can be displayed in vivo and in 3D. This novel angiographic variant of OCT offers the ability to visualize and measure vessel morphology providing a new insight into healthy, inflammatory and neoplastic skin lesions such as malignant melanoma...
March 3, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28243927/topical-treatment-of-rosacea-with-ivermectin-inhibits-gene-expression-of-cathelicidin-innate-immune-mediators-ll-37-and-klk5-in-reconstructed-and-ex-vivo-skin-models
#3
Séverine Thibaut de Ménonville, Carine Rosignoli, Estelle Soares, Manon Roquet, Béatrice Bertino, Jean-Paul Chappuis, Claire Defoin-Platel/Chaussade, David Piwnica
INTRODUCTION: Numerous intrinsic and extrinsic factors have been associated with the pathophysiology of rosacea, including dysregulation of innate immunity. A high level of cathelicidin antimicrobial peptides (e.g., LL-37) has been shown in the facial skin of patients with rosacea. Excessive production of both LL-37 and KLK5, the serine protease responsible for its cleavage, has been suggested to play a role in the pathophysiology of rosacea. Ivermectin 10 mg/g cream, indicated for the treatment of inflammatory lesions of rosacea, is reported to have dual anti-parasitic and anti-inflammatory properties...
February 27, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28220468/the-hair-shedding-visual-scale-a-quick-tool-to-assess-hair-loss-in-women
#4
María Abril Martínez-Velasco, Norma Elizabeth Vázquez-Herrera, Austin John Maddy, Daniel Asz-Sigall, Antonella Tosti
INTRODUCTION: Hair shedding is a common consequence of the normal hair cycle that changes with internal and external factors. Female pattern hair loss (FPHL) is difficult to assess in terms of shedding severity as the conscious perception of hair shedding varies according to each individual, and most utilized methods are semi-invasive or very time consuming. In this study, we establish and validate a hair-shedding scale for women with thick hair of different lengths. METHODS: A visual analog scale was developed for thick hair of short, medium, and long lengths by dividing a bundle of hairs of each length into nine piles of increasing hair amount that were then photographed and arranged in order of size...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28181194/topical-rapamycin-for-facial-angiofibromas-in-a-child-with-tuberous-sclerosis-complex-tsc-a-case-report-and-long-term-follow-up
#5
Daniel Ebrahimi-Fakhari, Cornelia Sigrid Lissi Müller, Sascha Meyer, Marina Flotats-Bastardas, Thomas Vogt, Claudia Pföhler
Tuberous sclerosis complex (TSC) is a genetic multisystem disorder with prominent skin involvement including facial angiofibromas that often appear in early childhood. Here we report the case of a 12-year-old girl with widespread disfiguring facial angiofibromas that were successfully treated with topical rapamycin, a mTOR inhibitor. A sustained remission of skin lesions was documented in detail over a 3-year follow-up. This case highlights the fact that topical rapamycin is a useful option in treating TSC-associated skin lesions...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28168623/a-report-of-two-cases-of-solid-facial-edema-in-acne
#6
Sarah Kuhn-Régnier, Joanna Mangana, Katrin Kerl, Jivko Kamarachev, Lars E French, Antonio Cozzio, Alexander A Navarini
INTRODUCTION: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published. METHODS: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. RESULTS: Both cases responded to oral isotretinoin, in one case combined with oral steroids...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28138890/adult-atopic-dermatitis-with-comorbid-atopic-disease-is-associated-with-increased-risk-of-infections-a-population-based-cross-sectional-study
#7
Saisindhu Narala, Tissa R Hata
INTRODUCTION: Atopic dermatitis (AD) is related to other atopic diseases asthma and allergic rhinitis. It is known that those with asthma or allergic rhinitis have impaired immune responses that may predispose them to infections. This study sought to determine whether adult AD is associated with systemic infections, and whether association is strengthened in those with AD plus another atopic disease. METHODS: This cross-sectional study obtained information from adults in the 2010 and the 2012 National Health Interview Survey (NHIS)...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28025775/systemic-treatment-of-adult-atopic-dermatitis-a-review
#8
REVIEW
Matteo Megna, Maddalena Napolitano, Cataldo Patruno, Alessia Villani, Anna Balato, Giuseppe Monfrecola, Fabio Ayala, Nicola Balato
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that predominantly affects children. However, it can persist in adulthood and/or start at older ages. Due to its chronic nature and frequently occurring relapses, AD has a substantial effect on patients' quality of life, often requiring long-term systemic treatment, especially in adult patients, who are more frequently refractory to adequate topical treatment with mid- to high-potent corticosteroids and/or calcineurin inhibitors. Therefore, treatment with systemic therapies is often needed to take control of the disease, prevent exacerbations and improve quality of life...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28004308/cutaneous-side-effects-and-transepidermal-water-loss-to-gefitinib-a-study-of-11-patients
#9
Franky Chandra, Dendi Sandiono, Unwati Sugiri, Oki Suwarsa, Hendra Gunawan
INTRODUCTION: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor. METHODS: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27995485/efficacy-and-safety-of-5-fluorouracil-0-5-salicylic-acid-10-in-the-field-directed-treatment-of-actinic-keratosis-a-phase-iii-randomized-double-blind-vehicle-controlled-trial
#10
Eggert Stockfleth, Ralph von Kiedrowski, Rolf Dominicus, John Ryan, Adam Ellery, Meritxell Falqués, Nathalie Ivanoff, Rosario Rodriguez Azeredo
INTRODUCTION: Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clinical guidelines recommend that all are treated. The objective of this study was to evaluate the efficacy and safety of 5-fluorouracil (5-FU) 0.5%/salicylic acid 10% as field-directed treatment of AK lesions. METHODS: This multicenter, double-blind, vehicle-controlled study (NCT02289768) randomized adults, with a 25 cm(2) area of skin on their face, bald scalp, or forehead covering 4-10 clinically confirmed AK lesions (grade I/II), 2:1 to treatment or vehicle applied topically once daily for 12 weeks...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27995484/metal-hypersensitivity-reactions-to-orthopedic-implants
#11
REVIEW
Wendy Z W Teo, Peter C Schalock
Total hip and knee replacement surgery using metal alloy devices is common. Type IV allergic reactions to these implants occur, though infrequently. While uncommon, peri-implant metal allergic reactions may cause significant morbidity for the affected individual-including aseptic loosening, pseudotumor formation and frank device failure. It is challenging to predict who will have these reactions, even in those with established pre-implant metal allergy. At this time, the scientific literature clearly supports few conclusions...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27921251/skin-manifestations-of-insulin-resistance-from-a-biochemical-stance-to-a-clinical-diagnosis-and-management
#12
REVIEW
Gloria González-Saldivar, René Rodríguez-Gutiérrez, Jorge Ocampo-Candiani, José Gerardo González-González, Minerva Gómez-Flores
Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40-50% of the global population is labeled at "high risk" (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27905011/under-treatment-of-patients-with-moderate-to-severe-psoriasis-in-the-united-states-analysis-of-medication-usage-with-health-plan-data
#13
April W Armstrong, J Will Koning, Simon Rowse, Huaming Tan, Carla Mamolo, Mandeep Kaur
INTRODUCTION: Psoriasis is a chronic inflammatory disorder with significant morbidity and mortality, but a persistent gap appears to exist for the adequate treatment of patients with moderate to severe disease. As the extent of under-treatment is unknown, we attempted to determine overall treatment patterns and estimate under-treatment using a large database. METHODS: Data from the US National Health and Wellness Survey was used to estimate the proportion of patients with mild, moderate or severe psoriasis...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27900658/fixed-combination-gels-of-adapalene-and-benzoyl-peroxide-provide-optimal-percutaneous-absorption-compared-to-monad-formulations-of-these-compounds-results-from-two-in-vitro-studies
#14
Hanan Osman-Ponchet, Karine Sevin, Alexandre Gaborit, Nathalie Wagner, Michel Poncet
INTRODUCTION: Adapalene 0.1%/benzoyl peroxide 2.5% (0.1% A/BPO) and adapalene 0.3%/BPO 2.5% (0.3% A/BPO) gels are fixed-combination options for the topical treatment of acne. However, the active compounds of these combinations are also available as monads, to be used in association or as monotherapy. These two in vitro studies determined the effect of different treatment regimens on the percutaneous absorption of adapalene (0.1% and 0.3%) gels and BPO 2.5% gel in ex vivo human skin. METHODS: In vitro percutaneous absorption studies were conducted using full-thickness human skin from six donors...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27888486/a-slowly-growing-orange-patch-on-the-cheek-diagnosis-of-lupus-vulgaris-20-years-after-onset-of-first-skin-changes
#15
Claudia Pföhler, Michael Klotz, Thomas Wehler, Thomas Vogt, Cornelia S L Müller
Tuberculosis is a worldwide occurring disease that affects approximately 20-40% of the world's population and in particular in developing countries. However, in times of migration, industrialised countries are again being more and more affected. Cutaneous tuberculosis is rare and lupus vulgaris represents its most common form. Preferentially, young adults in developing or low-income countries are affected from cutaneous tuberculosis, which usually occurs in previously sensitized persons with a high degree of tuberculin sensitivity and a good immunoresponse...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27882506/cosmetics-use-related-adverse-events-and-determinants-among-jigjiga-town-residents-eastern-ethiopia
#16
Arebu I Bilal, Zelalem Tilahun, Ebrahim D Osman, Anwar Mulugeta, Muktar Shekabdulahi, Derbew Fikadu Berhe
INTRODUCTION: Non-medicated cosmetics use is very common among the Ethiopian population. However, little is known about these products' related adverse events. The aim of this study was to assess the prevalence and determinants of cosmetics-related adverse events among Jigjiga Town residents, Eastern Ethiopia. METHODS: A community-based cross-sectional study design was conducted in May and June 2014. Semi-structured interviews were used to collect cosmetics use pattern and related adverse events...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27848170/vegas-verruciform-genital-associated-xanthoma-a-comprehensive-literature-review
#17
REVIEW
Katherine M Stiff, Philip R Cohen
INTRODUCTION: Verruciform xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) xanthomas of the penis, scrotum, and vulva are reviewed. METHODS: PubMed was used to search the following term: verruciform xanthoma...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27787745/current-and-emerging-medical-therapies-for-primary-hyperhidrosis
#18
REVIEW
Daniel A Grabell, Adelaide A Hebert
Hyperhidrosis is defined as the production of sweat beyond what is physiologically necessary to maintain thermal homeostasis. This disease state may (and typically does) have a significant impact on the patient's quality of life. Medications including antiperspirants, anticholinergics, and botulinum toxin have been shown to be effective in the management of hyperhidrosis. Several medical device technologies have also proven to be effective. This review article will explore the current and emerging pharmacological and medical device treatments for hyperhidrosis and provide a framework for treating patients who suffer with primary forms of hyperhidrosis...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28150110/9th-skin-academy-symposium-building-bridges-in-dermatology-chair-s-introduction
#19
REVIEW
Ulrike Blume-Peytavi
An introduction to the proceedings sharing an overview of presentations given as part of the 9th Skin Academy Symposium, held in Barcelona, Spain, April 9-10, 2016. The Skin Academy is an international and interdisciplinary dermatology initiative created to contribute to the growth in scientific knowledge of those dealing with skin diseases. This year's meeting aimed to 'build bridges' between the latest research and everyday clinical practice, providing dermatologists with important updates on some of the most common skin diseases, as well as current 'hot' topics...
January 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28150109/the-potential-psychological-impact-of-skin-conditions
#20
REVIEW
Ari Tuckman
Skin conditions such as psoriasis, eczema, and skin cancer often have a substantial psychologic and social impact on our patients. Some of these patients limit their life because they feel self-conscious about their symptoms. Sometimes, greater life satisfaction comes from accepting that perhaps some symptoms will remain or recur, even in an individual who responds well to treatment. This acceptance involves acknowledging the existence of symptoms, thereby allowing the patient to pursue a meaningful life that is not overly limited by their potential presence...
January 2017: Dermatology and Therapy
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